Effects of Valsartan on Restenosis in Patients with Arteriosclerosis Obliterans of the Lower Extremities Undergoing Interventional Therapy: A Prospective, Randomized, Single-Blind Trial.
CONCLUSIONS Valsartan inhibited the increase in hs-CRP and IL-6 levels, improved clinical efficacies, increased ABI, and decreased the restenosis rate after the interventional therapy in patients with arteriosclerosis obliterans of the lower extremities. PMID: 32541643 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - June 18, 2020 Category: Research Tags: Med Sci Monit Source Type: research

LncRNA LINC00152 Increases the Aggressiveness of Human Retinoblastoma and Enhances Carboplatin and Adriamycin Resistance by Regulating MiR-613/Yes-Associated Protein 1 (YAP1) Axis.
CONCLUSIONS Mechanistically, LINC00152 enhanced the aggressiveness of retinoblastoma and boosted carboplatin and adriamycin resistance by regulating YAP1 by sponging miR-613 in human retinoblastoma. PMID: 32541644 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - June 18, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Erratum: Measurement of the Combined Levels of Serum Uric Acid and Alanine Aminotransferase and the Risk of Metabolic Syndrome in a Population Aged 60 Years or More in Northeastern China.
Authors: Wang J, Wang Y, Chen F, Ma G, Wang D Abstract The authors informed the journal that several errors occurred in their manuscript and request the following to be corrected:  1. The affiliation for Jiabei Wang should be corrected from Department of Geriatric, Huangshi Central Hospital, Affiliated Hospital of Hubei Polytechnic University, Edong Healthcare Group, Huangshi, Hubei, P.R. China to:  Department of Geriatric, Huangshi Central Hospital, Affiliated Hospital of Hubei Polytechnic University, Edong Healthcare Group, Huangshi, Hubei, P.R. China Department of Geriatric, The First Affiliated Hospit...
Source: Medical Science Monitor - June 18, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Knowledge and Awareness of Venous Thromboembolism in Intensive Care Units in Zhejiang Province, China: A Cross-Sectional Survey.
CONCLUSIONS The survey assessed the VTE risk and key VTE management elements. However, high heterogeneities were detected in the assessment. The ICU doctors have relatively limited awareness of VTE. Thus, there is an urgent need to update and standardize the ICU VTE guidelines for the prevention and treatment of VTE in China. PMID: 32544921 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - June 18, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Prediction of MiR-21-5p in Promoting the Development of Lung Adenocarcinoma via PDZD2 Regulation.
Authors: Cui S, Lou S, Guo W, Jian S, Wu Y, Liu X, Lan X, Jia X Abstract BACKGROUND Lung adenocarcinoma currently accounts for the highest cancer-related mortality rate worldwide. MiR-21-5p has a vital role in various types of cancers. We have analyzed the miR-21-5p expression level, prognosis, and associated molecular pathways in lung adenocarcinoma with multiple bioinformatics databases. MATERIAL AND METHODS The Cancer Genome Atlas (TCGA) database was employed to fetch the miR-21-5p expression profile in multiple tumors. We used the UALCAN platform to assess the differential regulation of the miR-21-5p in healthy...
Source: Medical Science Monitor - June 16, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Changes of Bone Turnover Markers and Bone Tissue Content After Severe Osteoporotic Vertebral Compression Fracture.
CONCLUSIONS Bone histomorphometric analysis and bone turnover markers showed that severe osteoporotic vertebral compression fractures often associated with delayed union and nonunion during the healing process. PMID: 32535613 [PubMed - as supplied by publisher] (Source: Medical Science Monitor)
Source: Medical Science Monitor - June 16, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Clinical Characteristics and Prognosis of 27 Patients with Childhood Acute Megakaryoblastic Leukemia.
CONCLUSIONS Children with non-DS-AMKL have a high degree of malignancy and are prone to early recurrence with a poor prognosis, whereas the prognosis of DS-AMKL is relatively good. Recurrence after treatment and remission after 2 courses of treatment are important factors influencing the prognosis of childhood AMKL. Recurrence after transplantation is the leading cause of death in transplantation patients. PMID: 32532951 [PubMed - as supplied by publisher] (Source: Medical Science Monitor)
Source: Medical Science Monitor - June 15, 2020 Category: Research Tags: Med Sci Monit Source Type: research

LINC01207 Predicts Poor Prognosis and Suppresses Cell Growth and Metastasis via Regulating GSK-3 β/β-Catenin Signaling Pathway in Malignant Glioma.
CONCLUSIONS In summary, LINC01207 served as a tumor-related tumor suppress gene for malignant glioma through inhibiting of GSK-3ß/ß-catenin signaling pathway. PMID: 32533688 [PubMed - as supplied by publisher] (Source: Medical Science Monitor)
Source: Medical Science Monitor - June 15, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Comprehensive Analysis of Competing Endogenous RNA (ceRNA) Network Based on RNAs Differentially Expressed in Lung Adenocarcinoma Using The Cancer Genome Atlas (TCGA) Database.
Authors: Tang H, Wang Z, Shao Q, Wang Y, Yang Q Abstract BACKGROUND The aim of this study was to explore a comprehensive analysis of the competing endogenous (ceRNA) network of lung adenocarcinoma and predict its regulatory mechanism and prognosis correlation based on The Cancer Genome Atlas (TCGA) database. MATERIAL AND METHODS The genes expression data from 535 lung adenocarcinoma cases and 59 normal tissue cases were acquired and downloaded from TCGA database, and differentially expressed messenger RNA (mRNA), long noncoding RNA (lncRNA) and microRNA (miRNA) were selected primarily by "edgeR" package i...
Source: Medical Science Monitor - June 15, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Circular RNA (circRNA) CDYL Induces Myocardial Regeneration by ceRNA After Myocardial Infarction.
CONCLUSIONS CircCDYL can promote the proliferation of cardiomyocytes through the miR-4793-5p/APP pathway. PMID: 32522972 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - June 13, 2020 Category: Research Tags: Med Sci Monit Source Type: research

A  Novel Metallic Artifact Reduction Technique When Using a Computed Tomography-Guided Percutaneous Metallic Antenna to Ablate Malignant Pulmonary Nodules: A Qualitative and Quantitative Assessment.
A Novel Metallic Artifact Reduction Technique When Using a Computed Tomography-Guided Percutaneous Metallic Antenna to Ablate Malignant Pulmonary Nodules: A Qualitative and Quantitative Assessment. Med Sci Monit. 2020 Jun 11;26:e923541 Authors: Wang G, Wang Z, Jin Z Abstract BACKGROUND Metallic microwave ablation (MWA) antenna-related artifacts are usually created in conventional CT images, and these artifacts can influence the effect of ablation. The aim of this study was to evaluate a new type of metal artifact reduction (MAR+) technique in CT-guided MWA for lung cancer. MATERIAL AND M...
Source: Medical Science Monitor - June 13, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Application of Indirect Signs of Magnetic Resonance Imaging (MRI) in Prenatal Diagnosis of Abnormally Invasive Placenta.
CONCLUSIONS The indirect signs of dark intraplacental bands in T2WI sequence, focal outward bulging of the placenta, and abnormal placental vascularity are reliable signs of AIP. The indirect sign of dark intraplacental bands in T2WI sequence may be used to distinguish placental accreta from the other 2 subtypes of AIP. PMID: 32525848 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - June 13, 2020 Category: Research Tags: Med Sci Monit Source Type: research

An Individualized Immune Prognostic Index is a Superior Predictor of Survival of Hepatocellular Carcinoma.
Authors: Wang X, Wu Y, Wen D, Wu LY, Zhao Y, He Y, Yang H Abstract BACKGROUND The tumor microenvironment is largely orchestrated by the immune cells. Considerable evidence has shown their excellent clinicopathological application value in assessment of clinical outcomes and immunotherapy efficacy. Hence, a moderate, individualized prognostic signature based on immune cells that can estimate prognosis and reflect the immune microenvironment in hepatocellular carcinoma (HCC) patients is greatly needed. MATERIAL AND METHODS Here, we systematically analyzed the expression differences and survival prediction value of tu...
Source: Medical Science Monitor - June 13, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Relationship Between Ubiquitin-Specific Peptidase 18 and Hypertension in Polish Adult Male Subjects: A Cross-Sectional Pilot Study.
CONCLUSIONS This preliminary study found that serum USP18 levels were significantly higher in drug-naive male participants with arterial hypertension compared with normotensive controls. USP18 exerts cardiovascular-protective effects. Elevations of USP18 levels may indicate a counterregulatory process that is engaged during increases in pressure in the left ventricle. PMID: 32527992 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - June 13, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Identification of an Immune Score-Based Gene Panel with Prognostic Power for Oral Squamous Cell Carcinoma.
CONCLUSIONS An immune score-based risk signature constructed presently may be useful to decide appropriate treatment options for individual OSCC patients. PMID: 32529991 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - June 13, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Erratum: Multifunctional Polyethylene Glycol (PEG)-Poly (Lactic-Co-Glycolic Acid) (PLGA)-Based Nanoparticles Loading Doxorubicin and Tetrahydrocurcumin for Combined Chemoradiotherapy of Glioma.
Authors: Zhang X, Zhao L, Zhai G, Ji J, Liu A Abstract The authors informed the journal that an error occurred in their manuscript. Figure 2D was mistakenly overlooked by the authors during the galley proof stage. Reference: 1. Zhang X, Zhao L, Zhai G, Ji J, Liu A. Multifunctional Polyethylene Glycol (PEG)-Poly (Lactic-Co-Glycolic Acid) (PLGA)-Based Nanoparticles Loading Doxorubicin and Tetrahydrocurcumin for Combined Chemoradiotherapy of Glioma. Med Sci Monit, 2019; 25: 9737-9751. doi: 10.12659/MSM.918899. PMID: 32530909 [PubMed - as supplied by publisher] (Source: Medical Science Monitor)
Source: Medical Science Monitor - June 13, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Can Salivary Biomarkers Be Used as Predictors of Dental Caries in Young Adolescents?
CONCLUSIONS Salivary HNP-1, hBD-2, and LL-37 peptides were not found to have a significant predictive value. Therefore, socio-demographic and oral hygiene variables remain important caries predictors in early adolescents, suggesting the importance of the mechanical control of biofilm as the key measure for preventing caries. However, there is still a need for effective caries risk biomarkers, and additional research is needed in this area of caries risk prediction. PMID: 32518218 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - June 12, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Associations between IL-6 Variations and Congenital Heart Disease Incidence among Chinese Han People.
CONCLUSIONS IL-6 variant rs1800795 exhibited a close relation to CHD susceptibility among Chinese Han people while the mutant C allele promoted CHD incidence. But rs1800796 variant showed no such influence. PMID: 32519679 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - June 12, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Maternally-Expressed Gene 3 (MEG3)/miR-143-3p Regulates Injury to Periodontal Ligament Cells by Mediating the AKT/Inhibitory κB Kinase (IKK) Pathway.
CONCLUSIONS MEG3 overexpression inhibited LPS-induced injury in PDLCs by inactivating the AKT/IKK pathway via sponging miR-143-3p, providing a potential target for treatment of periodontitis. PMID: 32520926 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - June 12, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Erratum: The p66shc-Mediated Regulation of Hepatocyte Senescence Influences Hepatic Steatosis in Nonalcoholic Fatty Liver Disease.
Authors: Zhang J, Li Y, Wang B, Luo Y, Shi J, Zhao B Abstract The authors informed the journal that a few errors occurred in their manuscript. 1. The picture of L02/p66shc in Figure 5C of the published manuscript is incorrect and has been replaced the corrected one in Figure 5 shown below. 2. The ordinate of p21 mRNA expression histogram which is "0, 5, 10, 15, 20" is also incorrect, and it has been corrected to "0.0, 0.5, 1.0, 1.5, 2.0" in the Figure 5 shown below. 3. The ordinate of p66shc/GAPDH protein and p21/GAPDH protein histogram which is "0.0, 0.2, 0.4, 06., 0.8, 1.0" is also i...
Source: Medical Science Monitor - June 10, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Clinical Efficacy of Laminectomy with Instrumented Fixation in Treating Thoracolumbar Intradural Extramedullary Schwannomas: A Comparative Study.
This study investigated the clinical effect of laminectomy plus pedicle screw fixation in treating thoracolumbar intradural extramedullary schwannomas. MATERIAL AND METHODS Between October 2011 and May 2017, 57 patients undergoing resection of thoracolumbar schwannomas were retrospectively identified and included in the study. Based on the surgical procedures used, all participants were assigned to either the laminectomy-only group (n=33) or the combination group (laminectomy plus pedicle screw fixation, n=24). All participants were followed up for over 2 years. In the laminectomy, the spinal process, vertebral laminae, an...
Source: Medical Science Monitor - June 10, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Postconditioning with Nitrates Protects Against Myocardial Reperfusion Injury: A New Use for an Old Pharmacological Agent.
Authors: Meng Z, Gai W, Song D Abstract Early reperfusion remains the key therapy to salvage viable myocardium and must be applied as soon as possible following an acute myocardial infarction (AMI) to attenuate the ischemic insult. However, reperfusion injury may develop following reintroduction of blood and oxygen to vulnerable myocytes, which results in more severe cell death than in the preceding ischemic episode. Ischemic postconditioning (I-PostC) provides a cardioprotective effect in combination with pharmacological agents. Although nitrates have been tested in many experimental and clinical studies of acute ...
Source: Medical Science Monitor - June 10, 2020 Category: Research Tags: Med Sci Monit Source Type: research

A  Population Study to Identify Candidates for Cytoreductive Nephrectomy in Patients with Metastatic Sarcomatoid Renal Cell Carcinoma from the Surveillance, Epidemiology, and End Results (SEER) Database.
CONCLUSIONS Data from the SEER database showed that cytoreductive nephrectomy improved OS in patients with T1 and T2 metastatic sarcomatoid RCC with a significant long-term survival benefit of>6 months. PMID: 32516796 [PubMed - as supplied by publisher] (Source: Medical Science Monitor)
Source: Medical Science Monitor - June 10, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Percutaneous Endoscopic Lumbar Discectomy (PELD) via a Transforaminal and Interlaminar Combined Approach for Very Highly Migrated Lumbar Disc Herniation (LDH) Between L4/5 and L5/S1 Level.
This study reported a new endoscopic discectomy strategy for the treatment of very highly migrated LDH between the L4/5 and L5/S1 level. MATERIAL AND METHODS The current study retrospectively analyzed 12 patients who accepted PELD for very highly migrated LDH between the L4/5 and L5/S1 level. Under local anesthesia, the transforaminal approach was chosen for the L4/5 level and the interlaminar approach was chosen for the L5/S1 level. The 10-point visual analogue scale (VAS) was used to assess back pain (VAS-Back) and leg pain (VAS-Leg). Oswestry disability index (ODI) and Modified Mac Nab Criteria were adopted as the funct...
Source: Medical Science Monitor - June 9, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Sirtuin (Sirt) 3 Overexpression Prevents Retinopathy in Streptozotocin-Induced Diabetic Rats.
In this study, we aimed to investigate the effect of Sirt3 overexpression on retinopathy in streptozotocin (STZ)-induced diabetic rats, and to assess its mechanisms. MATERIAL AND METHODS Ntraperitoneal injection of STZ in rats was used to produce a diabetic model. The study rats were divided into 4 groups (n=6 for each group): a control group; a model group; a model+scrambled adenovirus group; and a model+Sirt3 overexpression group. Hematoxylin and eosin (H&E) staining determined the pathological changes of retina tissues. Immunohistochemistry, fluorescence quantitative polymerase chain reaction, and western blotting w...
Source: Medical Science Monitor - June 9, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Two-Dimensional and Three-Dimensional Transthoracic Echocardiography as Predictive and Prognostic Indicators of All-Cause Mortality in Heart Failure with Reduced Ejection Fraction in Patients with Ischemic Heart Disease.
This study aimed to compare the predictive role of two-dimensional transthoracic echocardiography (2D-TTE) and three-dimensional transthoracic echocardiography (3D-TTE) on in-hospital all-cause mortality in patients with heart failure and reduced ejection fraction (HFrEF) due to ischemic heart disease (IHD). MATERIAL AND METHODS Patients (N-224) with HFrEF due to IHD who had a left ventricular ejection fraction (LVEF)
Source: Medical Science Monitor - June 9, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Diagnostic Value of Superb Microvascular Imaging in Parotid Tumors.
CONCLUSIONS SMI more accurately evaluated the vascular distribution and vascularity of PTs than CDFI. SMI might be a potential non-invasive diagnostic method for PTs in clinical practice. PMID: 32507848 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - June 9, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Suppression of Circular RNA Hsa_circ_0109320 Attenuates Non-Small Cell Lung Cancer Progression via MiR-595/E2F7 Axis.
CONCLUSIONS Circ_0109320/miR-595/E2F2 axis may exert a pivotal role in the pathological mechanism of NSCLC progression, and it has potential application in the future treatment of NSCLC. PMID: 32508344 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - June 9, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Expression and Prognostic Significance of Cadherin 4 (CDH4) in Renal Cell Carcinoma.
CONCLUSIONS The transcriptional level of CDH4 may serve as an effective diagnostic and prognostic biomarker for RCC patients. PMID: 32511216 [PubMed - as supplied by publisher] (Source: Medical Science Monitor)
Source: Medical Science Monitor - June 9, 2020 Category: Research Tags: Med Sci Monit Source Type: research

miR-325-3p Overexpression Inhibits Proliferation and Metastasis of Bladder Cancer Cells by Regulating MT3.
CONCLUSIONS Downregulation of miR-325-3p in bladder cancer regulates cell proliferation, migration, invasion, and EMT by targeting MT3. Furthermore, miR-325-3p is a potential therapeutic target in treating bladder cancer. PMID: 32512576 [PubMed - as supplied by publisher] (Source: Medical Science Monitor)
Source: Medical Science Monitor - June 9, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Antimicrobial Activity of Nano-Magnesium Hydroxide Against Oral Bacteria and Application in Root Canal Sealer.
Authors: Meng Y, Zhang D, Jia X, Xiao K, Lin X, Yang Y, Xu D, Wang Q Abstract BACKGROUND The goal of the present work was to assess the antibacterial activity of nano-magnesium hydroxide (NMH) against Streptococcus mutans (S. mutans) and to explore the antimicrobial function of AH Plus™ sealer incorporating NMH. MATERIAL AND METHODS The antimicrobial behavior of NMH against S. mutans was evaluated with bactericidal tests. A modified direct contact test was used to assess the antimicrobial activity of unset AH Plus containing NMH after 5 minutes, 20 minutes, and 60 minutes of contact with bacteria. The antimic...
Source: Medical Science Monitor - June 8, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Combination of Xpert MTB/RIF and MTBDRplus for Diagnosing Tuberculosis in a Chinese District.
CONCLUSIONS The implementation of 2 rapid nucleic acid-based tests on sputum samples could facilitate the prompt and appropriate treatment of most TB cases. PMID: 32504464 [PubMed - as supplied by publisher] (Source: Medical Science Monitor)
Source: Medical Science Monitor - June 8, 2020 Category: Research Tags: Med Sci Monit Source Type: research

The Effects of High-Salt Gastric Intake on the Composition of the Intestinal Microbiota in Wistar Rats.
CONCLUSIONS A pilot study in Wistar rats showed that high-salt intake was associated with a change in the composition of the intestinal microbiota. PMID: 32504527 [PubMed - as supplied by publisher] (Source: Medical Science Monitor)
Source: Medical Science Monitor - June 8, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Bibliometric Analysis of Pediatric Liver Transplantation Research in PubMed from 2014 to 2018.
CONCLUSIONS We found 5 clusters and 7 aspects for pediatric liver transplantation. Additionally, calculation results showed that post-transplant lymphoproliferative disorder in pediatric patients and outcomes of multivisceral transplantation seem very promising. This conclusion is of great value for future exploratory research. PMID: 32493895 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - June 6, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Coronary Computed Tomography (CT) Angiography Characteristics of High-Risk Plaque: Correlation with Stress Myocardial Perfusion Imaging in Patients with Moderate Coronary Stenosis.
CONCLUSIONS CCTA characteristics of major plaques may improve the discrimination of ACS patients with myocardial ischemia on stress CTP. PMID: 32495750 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - June 6, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Identification of Differentially Expressed Genes and Signaling Pathways in Placenta Tissue of Early-Onset and Late-Onset Pre-Eclamptic Pregnancies by Integrated Bioinformatics Analysis.
CONCLUSIONS Integrated bioinformatic analyses provide us with a new approach to further understand the pathophysiology and molecular mechanisms underlying early-onset and late-onset PE. The DEGs identified in this study represent potential biomarkers for the early diagnosis of PE and may provide significant options the treatment of these 2 subtypes of PE. PMID: 32497025 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - June 6, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Association of +138I/D and Lys198Asn Polymorphisms in the Endothelin-1 Gene with Early Onset of Coronary Artery Disease among the Chinese Han Population.
This study aimed to investigate the association of 2 single-nucleotide polymorphisms (SNPs), +138 I/D and Lys198Asn) of the ET-1 gene,with early onset of CAD in Han Chinese patients. We investigated the effects of Lys198Asn polymorphism on ET-1 protein expression upon stimulation with pro-inflammatory factors. MATERIAL AND METHODS Genotyping of the 2 SNPs +138 I/D and Lys198Asn was performed in 88 early-onset CAD patients (≤55 years for males; ≤60 years for females) and 52 healthy control participants using a polymerase chain reaction direct sequencing method. The association of the 2 SNPs was analyzed with SPSS 17.0...
Source: Medical Science Monitor - June 6, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Methane Alleviates Inflammation and Apoptosis of Dextran Sulfate Sodium-Induced Inflammatory Bowel Diseases by Inhibiting Toll-Like Receptor 4 (TLR4)/Myeloid Differentiation Factor 88 (MyD88)/Nuclear Translocation of Nuclear Factor- κB (NF-κB) and Endoplasmic Reticulum Stress Pathways in Mice.
CONCLUSIONS MRS exerts protective effects on DSS-induced IBD via inhibiting inflammatory reaction, promoting anti-inflammatory capacity, suppressing oxidative stress, and ameliorating apoptosis. PMID: 32500859 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - June 6, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Tumor-Derived Exosomal eIF4E as a Biomarker for Survival Prediction in Patients with Non-Small Cell Lung Cancer.
Authors: Dong Q, Dong L, Liu S, Kong Y, Zhang M, Wang X Abstract BACKGROUND The aim of this study was to investigate the expression of tumor-derived exosomal RNA eIF4E (exo-eIF4E) in non-small cell lung cancer (NSCLC) and its correlation with prognosis. MATERIAL AND METHODS The Cancer Genome Atlas (TCGA) data was exacted to investigate the role of tissue eIF4E in NSCLC. We enrolled 99 NSCLC patients and 40 healthy volunteers with corresponding serum samples in this study. The levels of exo-eIF4E in the peripheral blood of each group were tested by quantitative polymerase chain reaction (PCR). The chi-squared test a...
Source: Medical Science Monitor - June 6, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Circulating miR-19a-3p and miR-483-5p as Novel Diagnostic Biomarkers for the Early Diagnosis of Gastric Cancer.
Authors: Cheng J, Yang A, Cheng S, Feng L, Wu X, Lu X, Zu M, Cui J, Yu H, Zou L Abstract BACKGROUND MicroRNAs (miRNAs) are attracting substantial interest as promising noninvasive biomarkers for gastric cancer (GC). Our study aimed to identify circulating miRNAs that are potential noninvasive markers for precancerous lesions and early gastric cancers (EGCs). MATERIAL AND METHODS Plasma specimens were obtained from 58 gastritis subjects, 54 patients with precancerous lesions, and 38 EGC patients for study. RESULTS Significant differences in the plasma expression levels of miR-19a-3p, miR-22-3p, miR-146a-5p, and miR-483-5p (all P
Source: Medical Science Monitor - June 5, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Absence of Long Noncoding RNA H19 Promotes Childhood Nephrotic Syndrome through Inhibiting ADCK4 Signal.
CONCLUSIONS H19 expression in blood samples may be a novel marker of the diagnosis of nephrotic syndrome in children. PMID: 32489187 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - June 5, 2020 Category: Research Tags: Med Sci Monit Source Type: research

The Effect of Shen Qi Wan Medicated Serum on NRK-52E Cells Proliferation and Migration by Targeting Aquaporin 1 (AQP1).
This study aimed to investigate the effect and underlying mechanism of SQW medicated serum on proliferation and migration in NRK-52E cells. MATERIAL AND METHODS We employed the real-time cell analysis (RTCA) system to investigate the effect of SQW medicated serum on proliferation and migration in NRK-52E cells. In addition, the migration was further investigated by using a wound-healing assay. The mRNA and protein expression level of aquaporin 1 (AQP1) of NRK-52E cells with SQW medicated serum-treated were quantified by real-time quantitative polymerase chain reaction (q-PCR) and western blot assay, respectively. Furthermo...
Source: Medical Science Monitor - June 5, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Analysis of Risk Factors for Adverse Cardiovascular Events in Elderly Patients with Acute Myocardial Infarction and Non-Alcoholic Fatty Liver Disease (NAFLD).
Authors: Xia W, Yang N, Li Y Abstract BACKGROUND The present research aimed to explore the risk factors for adverse cardiovascular events in elderly patients with acute myocardial infarction (AMI) combined with NAFLD. MATERIAL AND METHODS We included 325 AMI patients hospitalized in the Department of Cardiology. AMI patients underwent emergency thrombolysis or percutaneous coronary intervention (PCI). AMI patients were classified into NAFLD group and non-NAFLD group. General clinical data, creatinine and myocardial enzyme, GRACE scores of AMI patients were evaluated and compared between two groups. Incidence of adv...
Source: Medical Science Monitor - June 3, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Sevoflurane Preconditioning Confers Delayed Cardioprotection by Upregulating AMP-Activated Protein Kinase Levels to Restore Autophagic Flux in Ischemia-Reperfusion Rat Hearts.
CONCLUSIONS Sevoflurane exerts a delayed cardioprotective effects against myocardial injury in rats by activation of AMPK and restoration of I/R-impaired autophagic flux. PMID: 32476662 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - June 3, 2020 Category: Research Tags: Med Sci Monit Source Type: research

A Novel Nomogram Based on Immune Scores for Predicting Survival in Patients with Early-Stage Non-Small Cell Lung Cancer (NSCLC).
CONCLUSIONS Medium-immune scores are correlated with unsatisfactory prognosis in NSCLC (stage I-II) patients. In addition, the prognostic nomogram may be helpful in predicting OS for stage I and II NSCLC patients. PMID: 32479428 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - June 3, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Novel Prognostic Model for Gastric Cancer using 13 Co-Expression Long Non-Coding RNAs (LncRNAs).
CONCLUSIONS We constructed a novel prognostic model containing 13 co-expression lncRNAs and 3 clinical factors for gastric cancer patients. PMID: 32480397 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - June 3, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Combination of Fluorine-18 Fluorodeoxyglucose Positron-Emission Tomography/Computed Tomography ( ¹⁸F-FDG PET/CT) and Tumor Markers to Diagnose Lymph Node Metastasis in Non-Small Cell Lung Cancer (NSCLC): A Retrospective and Prospective Study.
Combination of Fluorine-18 Fluorodeoxyglucose Positron-Emission Tomography/Computed Tomography (¹⁸F-FDG PET/CT) and Tumor Markers to Diagnose Lymph Node Metastasis in Non-Small Cell Lung Cancer (NSCLC): A Retrospective and Prospective Study. Med Sci Monit. 2020 Jun 02;26:e922675 Authors: Zhai X, Guo Y, Qian X Abstract BACKGROUND The early diagnosis of lymph node (LN) metastasis is crucial for patients with non-small cell lung cancer (NSCLC). However, the diagnosis of LN metastasis mainly dependent on ¹⁸F-FDG PET/CT (fluorine-18 fluorodeoxyglucose positron-emission tomography/computed tomo...
Source: Medical Science Monitor - June 3, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Ginkgolide-Platinum(II) Complex GPt(II) Exhibits Therapeutic Effect on Depression in Mice via Upregulation of DA and 5-HT Neurotransmitters.
Authors: Yang T, Wang X, Liu L, Chen H, Wang N Abstract BACKGROUND Depression is the 5th most prevalent disorder adversely affecting the health of humans worldwide. The present study evaluated the antidepressant effect of ginkgolide-platinum(II) complex in vivo in a mice model of CMS-induced depression. MATERIAL AND METHODS Depression was induced in mice by social isolation followed by chronic mild stress. After stress, the mice were assigned randomly to a model group, a 3 mg/kg group, a 6 mg/kg group, and a 12 mg/kg group. The mice in the 3 treatment groups were intraperitoneally injected with a single dose of 3.0...
Source: Medical Science Monitor - June 3, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Ferroptosis in Low-Grade Glioma: A New Marker for Diagnosis and Prognosis.
This study is assessed an optimized ferroptosis gene panel for glioma treatment. MATERIAL AND METHODS We obtained 45 reports on ferroptosis-related proteins in PubMed and conducted a statistical test of the patients' overall survival (OS) in the TCGA GBMLGG and CGGA databases. The statistically significant genes were screened for an optimal panel, followed by GO and KEGG analysis and evaluated its correlation with known prognostic factors of glioma, including IDH1 mutation, methylated MGMT, tumor purity, 1p/19q LOH, and methionine cycle. RESULTS Eight genes panel (ALOX5, CISD1, FTL, CD44, FANCD2, NFE2L2, SLC1A5, and GOT1) ...
Source: Medical Science Monitor - June 3, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Association Between Monocyte Chemotactic Protein 1 Variants and Age-Related Macular Degeneration Onset Among Chinese People.
Authors: Zhang Y, Zhao G Abstract BACKGROUND We assessed the potential association between monocyte chemotactic protein 1 (MCP-1) variants (rs1024611 and rs3760396) and age-related macular degeneration (AMD) susceptibility among Chinese Han people. MATERIAL AND METHODS Our research included 129 AMD patients and 131 healthy controls. Genotyping for MCP-1 variants was performed in the 2 groups, and genotype and allele distributions were checked between groups by χ² analysis. Odds ratio (OR) and 95% confidence interval (CI) reflected the potential association between MCP-1 variants and AMD risk. The linkage d...
Source: Medical Science Monitor - June 3, 2020 Category: Research Tags: Med Sci Monit Source Type: research