Hydroxypyridinone-Coumarin Inhibits the Proliferation of MHCC97 and HepG2 Human Hepatocellular Carcinoma Cells and Down-Regulates the Phosphoinositide-3 Kinase Pathway.
This study aimed to investigate the effect of hydroxypyridinone-coumarin (HPC) on MHCC97 and HepG2 human HCC cells and the mechanisms involved. MATERIAL AND METHODS MHCC97 and HepG2 human HCC cells were cultured in vitro. An MTT cytotoxicity assay was used to assess cell viability and proliferation, with and without treatment with HPC. Cell autophagosomes were labeled with GFP-LC3 using confocal fluorescence microscopy. Western blot was used to measure protein expression. RESULTS HPC significantly reduced the cell proliferation rate in a concentration-dependent manner, with 2 µM of HPC resulting in a reduced prolifer...
Source: Medical Science Monitor - March 30, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Effect of HtrA1 Polymorphism on Sensitivity to Chemotherapy in Patients with Colon Cancer.
CONCLUSIONS HtrA1 rs1049331 polymorphism, but not rs11200638 polymorphism, can influence individual sensitivity to 5-FU-based treatment in stage III colon cancer patients. PMID: 32218415 [PubMed - as supplied by publisher] (Source: Medical Science Monitor)
Source: Medical Science Monitor - March 30, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Association Between EphA1 and Tumor Microenvironment in Gastric Carcinoma and its Clinical Significance.
CONCLUSIONS EphA1 can promote the occurrence and development of GC by its selective high expression in cancer tissues and its relationship with malignant clinical features and prognosis of GC patients. The underlying potential mechanism appears to involve enhancement of the tumor microenvironment, which via drives the expression of tumor microenvironment hallmark proteins IL-6 and VEGF. PMID: 32218416 [PubMed - as supplied by publisher] (Source: Medical Science Monitor)
Source: Medical Science Monitor - March 30, 2020 Category: Research Tags: Med Sci Monit Source Type: research

An Integrated Network Analysis of mRNA and Gene Expression Profiles in Parkinson's Disease.
CONCLUSIONS DEGs, including SORT1, CRYAB, PSMA1, and SDHA may have roles in the pathogenesis of PD through the MAPK, Wnt, and Notch signaling pathways. PMID: 32210219 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - March 28, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Impact of Interferon-alpha1b (IFN- α1b) on Antitumor Immune Response: An Interpretation of the Promising Therapeutic Effect of IFN-alpha1b on Melanoma.
CONCLUSIONS IFN-alpha1b has an immunostimulatory activity similar to IFN-alpha2b and possesses milder adverse effects on immune checkpoints and stronger inhibitory effects on melanoma cell growth than IFN-alpha2b. Therefore, IFN-alpha1b is a promising drug for the treatment of melanoma. PMID: 32210221 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - March 28, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Comparison of Transfemoral Cerebral Angiography and Transradial Cerebral Angiography Following a Shift in Practice During Four Years at a Single Center in China.
Authors: Ge B, Wei Y Abstract BACKGROUND Cerebral angiography, or intra-arterial digital subtraction angiography (DSA), is a fluoroscopic imaging technique. In China, until recently, transfemoral access (TFA) has been used, rather than transradial access (TRA). This retrospective study aimed to compare transfemoral cerebral angiography (TFCA) with transradial cerebral angiography (TRCA) consecutively performed by the same operator, at a single center in China, to determine whether there were benefits from the shift from TFA to TRA in terms of efficiency, safety, and feasibility. MATERIAL AND METHODS A review of 1,0...
Source: Medical Science Monitor - March 28, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Risk Factors for Recurrent L5-S1 Disc Herniation After Percutaneous Endoscopic Transforaminal Discectomy: A Retrospective Study.
Authors: Yu C, Zhan X, Liu C, Liao S, Xu J, Liang T, Zhang Z, Chen J Abstract BACKGROUND This retrospective study aimed to investigate the risk factors associated with the recurrence of L5-S1 disc herniation after percutaneous endoscopic transforaminal discectomy (PETD). MATERIAL AND METHODS There were 484 patients L5-S1 disc herniation who underwent PETD who were divided into the recurrence group (n=46) and the non-recurrence group (n=438). Transforaminal endoscopic approaches included modifications of the Yeung endoscopy spine system (YESS) (the intraforaminal intradiscal approach) and the transforaminal endoscop...
Source: Medical Science Monitor - March 28, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Effects of a Matrix Metalloproteinase Inhibitor-Eluting Stent on In-Stent Restenosis.
CONCLUSIONS Use of GM6001-eluting stents resulted in persistent and potent inhibition of intimal hyperplasia, an increase in luminal area, and no obvious thrombosis in the arteries of the mini-pigs. PMID: 32214058 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - March 28, 2020 Category: Research Tags: Med Sci Monit Source Type: research

RNA-Sequencing, Connectivity Mapping, and Molecular Docking to Investigate Ligand-Protein Binding for Potential Drug Candidates for the Treatment of Wilms Tumor.
CONCLUSIONS RNA-sequencing, connectivity mapping, and molecular docking to investigate ligand-protein binding identified retinoic acid and alsterpaullone as potential drug candidates for the treatment of Wilms tumor. PMID: 32214060 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - March 28, 2020 Category: Research Tags: Med Sci Monit Source Type: research

An Animal Study of Implantation of an Esophageal Pacemaker Based on Per-Oral Endoscopic Myotomy Approach for Alleviation of Esophageal Peristalsis Disorders.
CONCLUSIONS From this small-sample, short follow-up animal study, it was found that the implantation of esophageal electrodes and pacemaker based on POEM and NOTES is feasible, safe, and effective. Nevertheless, there is urgent need for long-term follow-up to confirm or disprove the safety of the procedure. PMID: 32214061 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - March 28, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Secreted Phosphoprotein 1 (SPP1) and Fibronectin 1 (FN1) Are Associated with Progression and Prognosis of Esophageal Cancer as Identified by Integrated Expression Profiles Analysis.
CONCLUSIONS Our analysis is the first to show that SPP1 and FN1 might work as biological markers of progression and prognosis in esophageal carcinoma (ESCA). PMID: 32208405 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - March 27, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Long Noncoding RNA (lncRNA) Maternally Expressed Gene 3 (MEG3) Participates in Chronic Obstructive Pulmonary Disease through Regulating Human Pulmonary Microvascular Endothelial Cell Apoptosis.
CONCLUSIONS Our study illustrated a protective effect of lncRNA MEG3-shRNA on CSE-induced HPMECs, indicting lncRNA MEG3 can be a new therapeutic approach for COPD treatment. PMID: 32201430 [PubMed - indexed for MEDLINE] (Source: Medical Science Monitor)
Source: Medical Science Monitor - March 25, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Effects of Lower Trapezius Strengthening Exercises on Pain, Dysfunction, Posture Alignment, Muscle Thickness and Contraction Rate in Patients with Neck Pain; Randomized Controlled Trial.
This study examined the effects of a lower trapezius exercise program on neck pain patients. MATERIAL AND METHODS The design of this study was a randomized controlled trial. A total of 40 neck pain patients participated in this study. Screening tests were performed and assigned to experimental group (n=20) and control group (n=20) using randomization program. Both groups underwent a scapula and thoracic spine stabilization exercise program. In addition, the experimental group implemented the lower trapezius strengthening exercise program. All interventions were applied 3 times per week for 4 weeks. Visual Analogue Scale (V...
Source: Medical Science Monitor - March 25, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Does Exposure to Computed Tomography Contrast Media Increase Risk of End-Stage Renal Disease?
CONCLUSIONS The use of CECT increased the risk of ESRD 1.2-fold in advanced and stable CKD outpatients after 5-year follow-up. PMID: 32203057 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - March 25, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Rhubarb and Astragalus Capsule Attenuates Renal Interstitial Fibrosis in Rats with Unilateral Ureteral Obstruction by Alleviating Apoptosis through Regulating Transforming Growth Factor beta1 (TGF- β1)/p38 Mitogen-Activated Protein Kinases (p38 MAPK) Pathway.
CONCLUSIONS RAC can improve the renal interstitial fibrosis induced by UUO, and the mechanism may be related to inhibition of renal tubular cell apoptosis via TGF-ß1/p38 MAPK pathway. PMID: 32205836 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - March 25, 2020 Category: Research Tags: Med Sci Monit Source Type: research

PIK3C3 Acts as a Tumor Suppressor in Esophageal Squamous Cell Carcinoma and Was Regulated by MiR-340-5p.
CONCLUSIONS MiR-340-5p functioned as an oncogene of ESCC by directly binding and repressing the expression of PIK3C3. PMID: 32207410 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - March 25, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Identification of Hub Genes in Hepatocellular Carcinoma Related to Progression and Prognosis by Weighted Gene Co-Expression Network Analysis.
CONCLUSIONS Our findings revealed that these 4 genes can be regarded as potential prognosticators and therapeutic targets for HCC. PMID: 32200387 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - March 24, 2020 Category: Research Tags: Med Sci Monit Source Type: research

A New Nomogram Allowing Physicians to Predict Patients at High Risk of Fever Occurring After Prostate Biopsy.
CONCLUSIONS This is the first study to develop a nomogram to predict fever after prostate biopsy via Biopsy-positive rate (BPR), Hematuria, and Urine WBC. Use of this nomogram might help prevent fever and infection, and could facilitate individualized medical treatment after prostate biopsy. PMID: 32200388 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - March 24, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Nanotechnology Strategies for the Analysis of Circulating Tumor DNA: A Review.
Authors: Chen X, Wang L, Lou J Abstract Circulating tumor DNA (ctDNA) describes the fragmented DNA released from tumor cells into the blood. The ctDNA may have the same genetic changes as the primary tumor. Currently, ctDNA has become a popular biomarker for diagnosis, treatment, real-time clinical response monitoring, and prognosis, for solid tumors. Detection of ctDNA is minimally invasive, and repeat sampling can easily be performed. However, due to its low quality and short DNA fragment length, ctDNA detection still faces challenges and requires highly sensitive analytical techniques. Recently, liquid biopsies ...
Source: Medical Science Monitor - March 24, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Lidocaine Reduces Sevoflurane Consumption and Improves Recovery Profile in Children Undergoing Major Spine Surgery.
CONCLUSIONS Lidocaine treatment decreases sevoflurane consumption and improves recovery profiles in children undergoing major spine surgery. PMID: 32198342 [PubMed - as supplied by publisher] (Source: Medical Science Monitor)
Source: Medical Science Monitor - March 22, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Systemic Analysis of the Prognosis-Related RNA Alternative Splicing Signals in Melanoma.
CONCLUSIONS AS events could be ideal indicators for SKCM prognosis. The key feature gene MCF2L played an important role in wild-type SKCM. PMID: 32199022 [PubMed - as supplied by publisher] (Source: Medical Science Monitor)
Source: Medical Science Monitor - March 22, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Down-Regulation of Fibroblast Growth Factor 2 (FGF2) Contributes to the Premature Senescence of Mouse Embryonic Fibroblast.
CONCLUSIONS The premature senescence of MEFs was at least partially caused by FGF2 deficiency. Exogenous FGF2 could alleviate the senescent phenotype. PMID: 32188838 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - March 21, 2020 Category: Research Tags: Med Sci Monit Source Type: research

A Modified Suture Technique in Hepaticojejunostomy.
Authors: Li G, Yuan L, Yu G, Xu Y, Liu J Abstract BACKGROUND Hepaticojejunostomy is a common biliary reconstruction procedure in hepatobiliary surgery. The suture technique plays a key role in the procedure. The conventional suture technique is complex and time-consuming. To facilitate the procedure, we performed it with a modified suture technique. In the present study, we evaluated the efficacy and safety of the technique in hepaticojejunostomy. MATERIAL AND METHODS We enrolled 120 adult patients who underwent hepaticojejunostomy. The patients were divided into a conventional group and a modified suture group acc...
Source: Medical Science Monitor - March 21, 2020 Category: Research Tags: Med Sci Monit Source Type: research

The p66shc-mediated Regulation of Hepatocyte Senescence Influences Hepatic Steatosis in Nonalcoholic Fatty Liver Disease.
CONCLUSIONS Our findings indicated that the increase in hepatocyte senescence and steatosis in NAFLD may be caused by the upregulation of p66shc expression, implying that strategies for p66shc-mediated regulation of hepatocyte senescence may provide new therapeutic tools for NAFLD. PMID: 32191680 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - March 21, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Experimental Study of Somatic Variants of Osteosarcoma by Whole-Exome Sequencing.
CONCLUSIONS The gene analysis confirmed that patients with osteosarcoma had a wide range of common gene mutations related to each other, which are involved in tumor-related metabolic pathways. These findings provide a basis for further gene-targeted therapy and pathway research. PMID: 32193367 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - March 21, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Social Capital and Sleep Quality in Individuals Who Self-Isolated for 14 Days During the Coronavirus Disease 2019 (COVID-19) Outbreak in January 2020 in China.
CONCLUSIONS During a period of individual self-isolation during the COVID-19 virus epidemic in central China, increased social capital improved sleep quality by reducing anxiety and stress. PMID: 32194290 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - March 21, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Interface Fixation Using Absorbable Screws versus Plate Fixation in Anterior Cervical Corpectomy and Fusion for Two-Level Cervical Spondylotic Myelopathy.
Authors: Qiu X, Zhao B, He X, Zhao C, Leng Z Abstract BACKGROUND We compared the clinical and radiographic outcomes between interface fixation using absorbable screws and plate fixation in anterior cervical corpectomy and fusion (ACCF) to evaluate the effectiveness of these 2 fixation methods for the treatment of 2-level cervical spondylotic myelopathy (CSM). MATERIAL AND METHODS From January 2014 to December 2016, a total of 220 patients who received 2-level ACCF were retrospectively collected. Among them, 108 patients were treated with interface fixation using absorbable screws (Group A) and 112 patients underwen...
Source: Medical Science Monitor - March 21, 2020 Category: Research Tags: Med Sci Monit Source Type: research

The Effects of Inhibition of MicroRNA-375 in a Mouse Model of Doxorubicin-Induced Cardiac Toxicity.
CONCLUSIONS Inhibition of miR-375 prevented oxidative damage in a mouse model of doxorubicin-induced cardiac toxicity in vivo and in doxorubicin-treated rat and mouse cardiomyocytes in vitro through the PDK1/AKT signaling pathway. PMID: 32186283 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - March 20, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Network Pharmacology Identifies the Mechanisms of Action of TaohongSiwu Decoction Against Essential Hypertension.
CONCLUSIONS This network pharmacological study can reveal potential mechanisms of multi-target and multi-component THSWT in the treatment of EH, provide a scientific basis for studying the mechanism. PMID: 32187175 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - March 20, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Drug-Induced Liver Injury: Clinical and Etiologic Features at a Large Tertiary Teaching Hospital in China.
CONCLUSIONS Our study provides a systematic etiological profile of DILI in Chinese patients, which can represent references for prevention, diagnosis and treatment, supporting and promoting efforts to ease the burden of this liver disease in China. PMID: 32172275 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - March 18, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Use of Electrical Impedance Tomography (EIT) to Estimate Global and Regional Lung Recruitment Volume (VREC) Induced by Positive End-Expiratory Pressure (PEEP): An Experiment in Pigs with Lung Injury.
CONCLUSIONS Close correlation and agreement were found between EIT-derived and flow-derived VREC measurements. The advantages of EIT-derived recruitability assessment included the avoidance of ventilation interruption and the ability to provide regional recruitment information. PMID: 32172276 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - March 18, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Correlation Between Enhancement Intensity in Contrast Enhancement Spectral Mammography and Types of Kinetic Curves in Magnetic Resonance Imaging.
CONCLUSIONS We compared subjective assessments of contrast enhancement on CESM with enhancement kinetic curves on MRI. The results showed that the level of enhancement on CESM and type of kinetic curves on MRI depends on the lesion type. PMID: 32173716 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - March 18, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Identification of Biomarkers for Osteosarcoma Based on Integration Strategy.
CONCLUSIONS The results showed that the expression levels of the 7 genes were highly consistent in the training and test sample sets, especially between the expression value of the gene ALPL and the plasma detection value of its encoded protein ALP. In particular, both the expression of gene ALPL and the plasma detection values of protein ALP encoded by gene ALPL showed a high degree of consistency among different data types. The identified lncRNA and genes effectively classified the samples proved so that they could be used as potential biomarkers of osteosarcoma. Our strategy may also be helpful for the identification of...
Source: Medical Science Monitor - March 18, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Dihydroartemisinin Prevents Distant Metastasis of Laryngeal Carcinoma by Inactivating STAT3 in Cancer Stem Cells.
CONCLUSIONS Taken together, our findings indicate that CSCs possess stronger invasive and metastatic capabilities than non-CSCs, and DHA inhibits invasion and prevents metastasis induced by CSCs by inhibiting STAT3 activation. PMID: 32176678 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - March 18, 2020 Category: Research Tags: Med Sci Monit Source Type: research

A Bibliometric Analysis Using CiteSpace of Publications from 1999 to 2018 on Patient Rehabilitation After Total Knee Arthroplasty.
CONCLUSIONS The findings from this bibliometric study provided insight into trends in clinical research publications in the field of rehabilitation following TKA for the past 20 years, including global trends in emerging areas of research. PMID: 32179730 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - March 18, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Identification of Hub Genes in High-Grade Serous Ovarian Cancer Using Weighted Gene Co-Expression Network Analysis.
CONCLUSIONS We found that FANCD2, PKD2, TBRG1, and DOCK5 had prognostic value and could be used as potential biomarkers for HGSOC treatment. PMID: 32180586 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - March 18, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Comparison of Effects of Abdominal Draw-In Lumbar Stabilization Exercises with and without Respiratory Resistance on Women with Low Back Pain: A Randomized Controlled Trial.
This study examined the effects of abdominal draw-in lumbar stabilization exercises (ADIM) with respiratory resistance on women ages 40-49 years with low back pain. MATERIAL AND METHODS Forty-four women ages 40-49 years were screened for participation and were randomly assigned to either a respiratory with resistance exercise group (n=22) or a control group (n=22). Abdominal draw-in lumbar stabilization exercises were administered to both groups, but only the respiratory with resistance exercise group received the respiratory resistance training. The exercise training lasted 50 min per session, 3 sessions per week for 4 we...
Source: Medical Science Monitor - March 18, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Serum Levels of Cystatin C, N-Terminal Pro-B-Type Natriuretic Peptide (NT-proBNP), and Cardiac Function in Patients with Unstable Angina Pectoris.
This study aimed to investigate the association between serum levels of cystatin C, N-terminal pro-B-type natriuretic peptide (NT-proBNP), and cardiac function in patients with unstable angina pectoris (UAP). MATERIAL AND METHODS A cross-sectional observational study was conducted at a single center and recruited 300 patients (214 men and 86 women), who were diagnosed with UAP between June 2018 to December 2018. The patients had serum levels of NT-ProBNP measured and were divided into four groups according to the serum levels of cystatin C: Q1, 0.49-0.83 mg/L; Q2, 0.84-1.04 mg/L; Q3, 1.05-1.38 mg/L; Q4, 1.39-4.21 mg/L. Car...
Source: Medical Science Monitor - March 15, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Exonuclease 1 (Exo1) Participates in Mammalian Non-Homologous End Joining and Contributes to Drug Resistance in Ovarian Cancer.
CONCLUSIONS Exo1 participated in mammalian non-homologous end joining and contributed to drug resistance in ovarian cancer. PMID: 32167078 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - March 15, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Genetic Relationship Between Endothelin-1 Gene Polymorphisms and Intracerebral Hemorrhage Among Chinese Han People.
CONCLUSIONS EDN1 rs64581aEDN1 rs6458155 polymorphism may be a risk factor of ICH among Chinese Han people.55 polymorphism may be a risk factor of ICH among Chinese Han people. PMID: 32168316 [PubMed - as supplied by publisher] (Source: Medical Science Monitor)
Source: Medical Science Monitor - March 15, 2020 Category: Research Tags: Med Sci Monit Source Type: research

MicroRNA-143 Increases Oxidative Stress and Myocardial Cell Apoptosis in a Mouse Model of Doxorubicin-Induced Cardiac Toxicity.
CONCLUSIONS In a mouse model of doxorubicin-induced cardiac toxicity, miR-143 increased oxidative stress and myocardial cell apoptosis following doxorubicin treatment by inhibiting AKT. PMID: 32170053 [PubMed - as supplied by publisher] (Source: Medical Science Monitor)
Source: Medical Science Monitor - March 15, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Relationship of Blood Eosinophils with Fractional Exhaled Nitric Oxide and Pulmonary Function Parameters in Chronic Obstructive Pulmonary Disease (COPD) Exacerbation.
This study explored the correlations of blood eosinophils with fractional exhaled nitric oxide (FeNO) and pulmonary function parameters in acute exacerbation of chronic obstructive pulmonary disease (AECOPD). MATERIAL AND METHODS The data of patients with AECOPD at our hospital admitted between July 2018 and June 2019 were retrospectively analyzed. All patients were stratified into an eosinophilic group (≥2%) or a noneosinophilic group (
Source: Medical Science Monitor - March 14, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Thyroid Hormone Metabolite 3-Iodothyronamine (T1AM) Alleviates Hypoxia/Reoxygenation-Induced Cardiac Myocyte Apoptosis via Akt/FoxO1 Pathway.
CONCLUSIONS Exogenous T1AM protects against cell injury induced by H/R in AC-16 cells via regulation of the FoxO signaling pathway. Our results suggest that T1AM can play a preventive role in myocardial H/R injury and also provide new insight for clinical management of AMI patients. PMID: 32162616 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - March 14, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Biomechanics of Anterior Ring Internal Fixation Combined with Sacroiliac Screw Fixation for Tile C3 Pelvic Fractures.
CONCLUSIONS Anterior ring internal fixators combined with sacroiliac screws can effectively fix Tile C3 pelvic fractures. PMID: 32163378 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - March 14, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Silencing EPB41 Gene Expression Leads to Cell Cycle Arrest, Migration Inhibition, and Upregulation of Cell Surface Antigen in DC2.4 Cells.
Authors: Zhao Q, Li Y, Li Y, Ji X, Li H, Wu D, Wei W, Xinchun W Abstract BACKGROUND Protein 4.1R (EPB41) is the main cytoskeleton component of the erythrocyte membrane and may be involved in cell migration and adhesion. Previous research discovered overexpression of 4.1R in the thymus of patients with myasthenia gravis (MG). The protein 4.1R on dendritic cells may play a pivotal role in MG pathogenesis. This research investigated the effects of small interfering RNA 4.1R-siRNA on cell migration, cell cycle, and surface antigen expression of DC2.4 mouse dendritic cells, thus providing a new direction for the study o...
Source: Medical Science Monitor - March 12, 2020 Category: Research Tags: Med Sci Monit Source Type: research

The Value of Thoracic Lavage in the Treatment of Anastomotic Leakage After Surgery for Type III Esophageal Atresia.
CONCLUSIONS The technique of thoracic lavage is simple, economical and convenient and can effectively promote the healing of anastomotic fistulas, accelerate postoperative recovery in children and reduce the cost of treatment. PMID: 32158013 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - March 12, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Crucial Gene Identification in Carotid Atherosclerosis Based on Peripheral Blood Mononuclear Cell (PBMC) Data by Weighted (Gene) Correlation Network Analysis (WGCNA).
CONCLUSIONS We detected 8 modules for the events group and 6 modules for the no-events group. The hub genes for modules and crucial genes of the DEG co-expression network were also identified. These genes might serve as potential targets for medical therapies and biomarkers for diagnosis and prognosis. Further experimental and biological studies are needed to elucidate the role of these crucial genes in the progression of carotid atherosclerosis. PMID: 32160184 [PubMed - as supplied by publisher] (Source: Medical Science Monitor)
Source: Medical Science Monitor - March 12, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Overexpression of Karyopherin Subunit alpha 2 (KPNA2) Predicts Unfavorable Prognosis and Promotes Bladder Cancer Tumorigenicity via the P53 Pathway.
CONCLUSIONS KPNA2 is an oncogenic factor that facilitates BC tumorigenicity through the P53 pathway. PMID: 32147666 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - March 11, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Incidence and Risk Factors for Suicide Death among Kaposi's Sarcoma Patients: A Surveillance, Epidemiology, and End Results Analysis.
CONCLUSIONS Clinicians and caregivers can apply our findings to identify KS patients with high suicide risk characteristics (white race, age of 18-44 years, non-chemotherapy) and exert timely interventions during patient diagnosis, treatment, and follow-up to reduce the suicide rate in this population. PMID: 32148334 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - March 11, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Protective effect of BMSCs-derived exosomes mediated by BDNF on TBI via miR-216a-5p.
CONCLUSIONS In conclusion, we found that BDNF-mediated MSCs-Exo can better promote neurogenesis and inhibit apoptosis than MSCs-Exo in rats after TBI, and the mechanism may be related to the high expression of miR-216a-5p. PMID: 32150531 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - March 11, 2020 Category: Research Tags: Med Sci Monit Source Type: research