PIK3C3 Acts as a Tumor Suppressor in Esophageal Squamous Cell Carcinoma and Was Regulated by MiR-340-5p.
CONCLUSIONS MiR-340-5p functioned as an oncogene of ESCC by directly binding and repressing the expression of PIK3C3. PMID: 32207410 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - March 25, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Identification of Hub Genes in Hepatocellular Carcinoma Related to Progression and Prognosis by Weighted Gene Co-Expression Network Analysis.
CONCLUSIONS Our findings revealed that these 4 genes can be regarded as potential prognosticators and therapeutic targets for HCC. PMID: 32200387 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - March 24, 2020 Category: Research Tags: Med Sci Monit Source Type: research

A New Nomogram Allowing Physicians to Predict Patients at High Risk of Fever Occurring After Prostate Biopsy.
CONCLUSIONS This is the first study to develop a nomogram to predict fever after prostate biopsy via Biopsy-positive rate (BPR), Hematuria, and Urine WBC. Use of this nomogram might help prevent fever and infection, and could facilitate individualized medical treatment after prostate biopsy. PMID: 32200388 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - March 24, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Nanotechnology Strategies for the Analysis of Circulating Tumor DNA: A Review.
Authors: Chen X, Wang L, Lou J Abstract Circulating tumor DNA (ctDNA) describes the fragmented DNA released from tumor cells into the blood. The ctDNA may have the same genetic changes as the primary tumor. Currently, ctDNA has become a popular biomarker for diagnosis, treatment, real-time clinical response monitoring, and prognosis, for solid tumors. Detection of ctDNA is minimally invasive, and repeat sampling can easily be performed. However, due to its low quality and short DNA fragment length, ctDNA detection still faces challenges and requires highly sensitive analytical techniques. Recently, liquid biopsies ...
Source: Medical Science Monitor - March 24, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Lidocaine Reduces Sevoflurane Consumption and Improves Recovery Profile in Children Undergoing Major Spine Surgery.
CONCLUSIONS Lidocaine treatment decreases sevoflurane consumption and improves recovery profiles in children undergoing major spine surgery. PMID: 32198342 [PubMed - as supplied by publisher] (Source: Medical Science Monitor)
Source: Medical Science Monitor - March 22, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Systemic Analysis of the Prognosis-Related RNA Alternative Splicing Signals in Melanoma.
CONCLUSIONS AS events could be ideal indicators for SKCM prognosis. The key feature gene MCF2L played an important role in wild-type SKCM. PMID: 32199022 [PubMed - as supplied by publisher] (Source: Medical Science Monitor)
Source: Medical Science Monitor - March 22, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Down-Regulation of Fibroblast Growth Factor 2 (FGF2) Contributes to the Premature Senescence of Mouse Embryonic Fibroblast.
CONCLUSIONS The premature senescence of MEFs was at least partially caused by FGF2 deficiency. Exogenous FGF2 could alleviate the senescent phenotype. PMID: 32188838 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - March 21, 2020 Category: Research Tags: Med Sci Monit Source Type: research

A Modified Suture Technique in Hepaticojejunostomy.
Authors: Li G, Yuan L, Yu G, Xu Y, Liu J Abstract BACKGROUND Hepaticojejunostomy is a common biliary reconstruction procedure in hepatobiliary surgery. The suture technique plays a key role in the procedure. The conventional suture technique is complex and time-consuming. To facilitate the procedure, we performed it with a modified suture technique. In the present study, we evaluated the efficacy and safety of the technique in hepaticojejunostomy. MATERIAL AND METHODS We enrolled 120 adult patients who underwent hepaticojejunostomy. The patients were divided into a conventional group and a modified suture group acc...
Source: Medical Science Monitor - March 21, 2020 Category: Research Tags: Med Sci Monit Source Type: research

The p66shc-mediated Regulation of Hepatocyte Senescence Influences Hepatic Steatosis in Nonalcoholic Fatty Liver Disease.
CONCLUSIONS Our findings indicated that the increase in hepatocyte senescence and steatosis in NAFLD may be caused by the upregulation of p66shc expression, implying that strategies for p66shc-mediated regulation of hepatocyte senescence may provide new therapeutic tools for NAFLD. PMID: 32191680 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - March 21, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Experimental Study of Somatic Variants of Osteosarcoma by Whole-Exome Sequencing.
CONCLUSIONS The gene analysis confirmed that patients with osteosarcoma had a wide range of common gene mutations related to each other, which are involved in tumor-related metabolic pathways. These findings provide a basis for further gene-targeted therapy and pathway research. PMID: 32193367 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - March 21, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Social Capital and Sleep Quality in Individuals Who Self-Isolated for 14 Days During the Coronavirus Disease 2019 (COVID-19) Outbreak in January 2020 in China.
CONCLUSIONS During a period of individual self-isolation during the COVID-19 virus epidemic in central China, increased social capital improved sleep quality by reducing anxiety and stress. PMID: 32194290 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - March 21, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Interface Fixation Using Absorbable Screws versus Plate Fixation in Anterior Cervical Corpectomy and Fusion for Two-Level Cervical Spondylotic Myelopathy.
Authors: Qiu X, Zhao B, He X, Zhao C, Leng Z Abstract BACKGROUND We compared the clinical and radiographic outcomes between interface fixation using absorbable screws and plate fixation in anterior cervical corpectomy and fusion (ACCF) to evaluate the effectiveness of these 2 fixation methods for the treatment of 2-level cervical spondylotic myelopathy (CSM). MATERIAL AND METHODS From January 2014 to December 2016, a total of 220 patients who received 2-level ACCF were retrospectively collected. Among them, 108 patients were treated with interface fixation using absorbable screws (Group A) and 112 patients underwen...
Source: Medical Science Monitor - March 21, 2020 Category: Research Tags: Med Sci Monit Source Type: research

The Effects of Inhibition of MicroRNA-375 in a Mouse Model of Doxorubicin-Induced Cardiac Toxicity.
CONCLUSIONS Inhibition of miR-375 prevented oxidative damage in a mouse model of doxorubicin-induced cardiac toxicity in vivo and in doxorubicin-treated rat and mouse cardiomyocytes in vitro through the PDK1/AKT signaling pathway. PMID: 32186283 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - March 20, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Network Pharmacology Identifies the Mechanisms of Action of TaohongSiwu Decoction Against Essential Hypertension.
CONCLUSIONS This network pharmacological study can reveal potential mechanisms of multi-target and multi-component THSWT in the treatment of EH, provide a scientific basis for studying the mechanism. PMID: 32187175 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - March 20, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Drug-Induced Liver Injury: Clinical and Etiologic Features at a Large Tertiary Teaching Hospital in China.
CONCLUSIONS Our study provides a systematic etiological profile of DILI in Chinese patients, which can represent references for prevention, diagnosis and treatment, supporting and promoting efforts to ease the burden of this liver disease in China. PMID: 32172275 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - March 18, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Use of Electrical Impedance Tomography (EIT) to Estimate Global and Regional Lung Recruitment Volume (VREC) Induced by Positive End-Expiratory Pressure (PEEP): An Experiment in Pigs with Lung Injury.
CONCLUSIONS Close correlation and agreement were found between EIT-derived and flow-derived VREC measurements. The advantages of EIT-derived recruitability assessment included the avoidance of ventilation interruption and the ability to provide regional recruitment information. PMID: 32172276 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - March 18, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Correlation Between Enhancement Intensity in Contrast Enhancement Spectral Mammography and Types of Kinetic Curves in Magnetic Resonance Imaging.
CONCLUSIONS We compared subjective assessments of contrast enhancement on CESM with enhancement kinetic curves on MRI. The results showed that the level of enhancement on CESM and type of kinetic curves on MRI depends on the lesion type. PMID: 32173716 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - March 18, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Identification of Biomarkers for Osteosarcoma Based on Integration Strategy.
CONCLUSIONS The results showed that the expression levels of the 7 genes were highly consistent in the training and test sample sets, especially between the expression value of the gene ALPL and the plasma detection value of its encoded protein ALP. In particular, both the expression of gene ALPL and the plasma detection values of protein ALP encoded by gene ALPL showed a high degree of consistency among different data types. The identified lncRNA and genes effectively classified the samples proved so that they could be used as potential biomarkers of osteosarcoma. Our strategy may also be helpful for the identification of...
Source: Medical Science Monitor - March 18, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Dihydroartemisinin Prevents Distant Metastasis of Laryngeal Carcinoma by Inactivating STAT3 in Cancer Stem Cells.
CONCLUSIONS Taken together, our findings indicate that CSCs possess stronger invasive and metastatic capabilities than non-CSCs, and DHA inhibits invasion and prevents metastasis induced by CSCs by inhibiting STAT3 activation. PMID: 32176678 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - March 18, 2020 Category: Research Tags: Med Sci Monit Source Type: research

A Bibliometric Analysis Using CiteSpace of Publications from 1999 to 2018 on Patient Rehabilitation After Total Knee Arthroplasty.
CONCLUSIONS The findings from this bibliometric study provided insight into trends in clinical research publications in the field of rehabilitation following TKA for the past 20 years, including global trends in emerging areas of research. PMID: 32179730 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - March 18, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Identification of Hub Genes in High-Grade Serous Ovarian Cancer Using Weighted Gene Co-Expression Network Analysis.
CONCLUSIONS We found that FANCD2, PKD2, TBRG1, and DOCK5 had prognostic value and could be used as potential biomarkers for HGSOC treatment. PMID: 32180586 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - March 18, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Comparison of Effects of Abdominal Draw-In Lumbar Stabilization Exercises with and without Respiratory Resistance on Women with Low Back Pain: A Randomized Controlled Trial.
This study examined the effects of abdominal draw-in lumbar stabilization exercises (ADIM) with respiratory resistance on women ages 40-49 years with low back pain. MATERIAL AND METHODS Forty-four women ages 40-49 years were screened for participation and were randomly assigned to either a respiratory with resistance exercise group (n=22) or a control group (n=22). Abdominal draw-in lumbar stabilization exercises were administered to both groups, but only the respiratory with resistance exercise group received the respiratory resistance training. The exercise training lasted 50 min per session, 3 sessions per week for 4 we...
Source: Medical Science Monitor - March 18, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Serum Levels of Cystatin C, N-Terminal Pro-B-Type Natriuretic Peptide (NT-proBNP), and Cardiac Function in Patients with Unstable Angina Pectoris.
This study aimed to investigate the association between serum levels of cystatin C, N-terminal pro-B-type natriuretic peptide (NT-proBNP), and cardiac function in patients with unstable angina pectoris (UAP). MATERIAL AND METHODS A cross-sectional observational study was conducted at a single center and recruited 300 patients (214 men and 86 women), who were diagnosed with UAP between June 2018 to December 2018. The patients had serum levels of NT-ProBNP measured and were divided into four groups according to the serum levels of cystatin C: Q1, 0.49-0.83 mg/L; Q2, 0.84-1.04 mg/L; Q3, 1.05-1.38 mg/L; Q4, 1.39-4.21 mg/L. Car...
Source: Medical Science Monitor - March 15, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Exonuclease 1 (Exo1) Participates in Mammalian Non-Homologous End Joining and Contributes to Drug Resistance in Ovarian Cancer.
CONCLUSIONS Exo1 participated in mammalian non-homologous end joining and contributed to drug resistance in ovarian cancer. PMID: 32167078 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - March 15, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Genetic Relationship Between Endothelin-1 Gene Polymorphisms and Intracerebral Hemorrhage Among Chinese Han People.
CONCLUSIONS EDN1 rs64581aEDN1 rs6458155 polymorphism may be a risk factor of ICH among Chinese Han people.55 polymorphism may be a risk factor of ICH among Chinese Han people. PMID: 32168316 [PubMed - as supplied by publisher] (Source: Medical Science Monitor)
Source: Medical Science Monitor - March 15, 2020 Category: Research Tags: Med Sci Monit Source Type: research

MicroRNA-143 Increases Oxidative Stress and Myocardial Cell Apoptosis in a Mouse Model of Doxorubicin-Induced Cardiac Toxicity.
CONCLUSIONS In a mouse model of doxorubicin-induced cardiac toxicity, miR-143 increased oxidative stress and myocardial cell apoptosis following doxorubicin treatment by inhibiting AKT. PMID: 32170053 [PubMed - as supplied by publisher] (Source: Medical Science Monitor)
Source: Medical Science Monitor - March 15, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Relationship of Blood Eosinophils with Fractional Exhaled Nitric Oxide and Pulmonary Function Parameters in Chronic Obstructive Pulmonary Disease (COPD) Exacerbation.
This study explored the correlations of blood eosinophils with fractional exhaled nitric oxide (FeNO) and pulmonary function parameters in acute exacerbation of chronic obstructive pulmonary disease (AECOPD). MATERIAL AND METHODS The data of patients with AECOPD at our hospital admitted between July 2018 and June 2019 were retrospectively analyzed. All patients were stratified into an eosinophilic group (≥2%) or a noneosinophilic group (
Source: Medical Science Monitor - March 14, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Thyroid Hormone Metabolite 3-Iodothyronamine (T1AM) Alleviates Hypoxia/Reoxygenation-Induced Cardiac Myocyte Apoptosis via Akt/FoxO1 Pathway.
CONCLUSIONS Exogenous T1AM protects against cell injury induced by H/R in AC-16 cells via regulation of the FoxO signaling pathway. Our results suggest that T1AM can play a preventive role in myocardial H/R injury and also provide new insight for clinical management of AMI patients. PMID: 32162616 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - March 14, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Biomechanics of Anterior Ring Internal Fixation Combined with Sacroiliac Screw Fixation for Tile C3 Pelvic Fractures.
CONCLUSIONS Anterior ring internal fixators combined with sacroiliac screws can effectively fix Tile C3 pelvic fractures. PMID: 32163378 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - March 14, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Silencing EPB41 Gene Expression Leads to Cell Cycle Arrest, Migration Inhibition, and Upregulation of Cell Surface Antigen in DC2.4 Cells.
Authors: Zhao Q, Li Y, Li Y, Ji X, Li H, Wu D, Wei W, Xinchun W Abstract BACKGROUND Protein 4.1R (EPB41) is the main cytoskeleton component of the erythrocyte membrane and may be involved in cell migration and adhesion. Previous research discovered overexpression of 4.1R in the thymus of patients with myasthenia gravis (MG). The protein 4.1R on dendritic cells may play a pivotal role in MG pathogenesis. This research investigated the effects of small interfering RNA 4.1R-siRNA on cell migration, cell cycle, and surface antigen expression of DC2.4 mouse dendritic cells, thus providing a new direction for the study o...
Source: Medical Science Monitor - March 12, 2020 Category: Research Tags: Med Sci Monit Source Type: research

The Value of Thoracic Lavage in the Treatment of Anastomotic Leakage After Surgery for Type III Esophageal Atresia.
CONCLUSIONS The technique of thoracic lavage is simple, economical and convenient and can effectively promote the healing of anastomotic fistulas, accelerate postoperative recovery in children and reduce the cost of treatment. PMID: 32158013 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - March 12, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Crucial Gene Identification in Carotid Atherosclerosis Based on Peripheral Blood Mononuclear Cell (PBMC) Data by Weighted (Gene) Correlation Network Analysis (WGCNA).
CONCLUSIONS We detected 8 modules for the events group and 6 modules for the no-events group. The hub genes for modules and crucial genes of the DEG co-expression network were also identified. These genes might serve as potential targets for medical therapies and biomarkers for diagnosis and prognosis. Further experimental and biological studies are needed to elucidate the role of these crucial genes in the progression of carotid atherosclerosis. PMID: 32160184 [PubMed - as supplied by publisher] (Source: Medical Science Monitor)
Source: Medical Science Monitor - March 12, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Overexpression of Karyopherin Subunit alpha 2 (KPNA2) Predicts Unfavorable Prognosis and Promotes Bladder Cancer Tumorigenicity via the P53 Pathway.
CONCLUSIONS KPNA2 is an oncogenic factor that facilitates BC tumorigenicity through the P53 pathway. PMID: 32147666 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - March 11, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Incidence and Risk Factors for Suicide Death among Kaposi's Sarcoma Patients: A Surveillance, Epidemiology, and End Results Analysis.
CONCLUSIONS Clinicians and caregivers can apply our findings to identify KS patients with high suicide risk characteristics (white race, age of 18-44 years, non-chemotherapy) and exert timely interventions during patient diagnosis, treatment, and follow-up to reduce the suicide rate in this population. PMID: 32148334 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - March 11, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Protective effect of BMSCs-derived exosomes mediated by BDNF on TBI via miR-216a-5p.
CONCLUSIONS In conclusion, we found that BDNF-mediated MSCs-Exo can better promote neurogenesis and inhibit apoptosis than MSCs-Exo in rats after TBI, and the mechanism may be related to the high expression of miR-216a-5p. PMID: 32150531 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - March 11, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Interleukin-37 Attenuates Lipopolysaccharide (LPS)-Induced Neonatal Acute Respiratory Distress Syndrome in Young Mice via Inhibition of Inflammation and Cell Apoptosis.
CONCLUSIONS The present results suggest that IL-37 protect against LPS-induced lung injury through inhibition of inflammation and apoptosis in lung tissue in an LPS-induced neonatal ARDS model. Hence, IL-37 may be considered as a potential therapeutic agent for neonatal ARDS. PMID: 32152260 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - March 11, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Analysis of Masticatory Muscle Activity Based on Presence of Temporomandibular Joint Disorders.
This study was conducted to analyze the activity of masticatory muscles depending on the presence of temporomandibular joint disorders (TMD) when foods of various hardness are masticated. MATERIAL AND METHODS We enrolled 20 subjects (13 men and 7 women) who met our selection criteria, and they were divided into 3 groups (the Disorder Group, the Malalignment Group, and the Control Group) based on surveys and screening inspection. The average of reference voluntary contraction (RVC) was used to measure masticatory muscle activity. Using surface electromyography (SEMG) for each group during masticatory activity, the activitie...
Source: Medical Science Monitor - March 11, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Downregulated Long Non-Coding RNA MSC-AS1 Inhibits Osteosarcoma Progression and Increases Sensitivity to Cisplatin by Binding to MicroRNA-142.
CONCLUSIONS Our study demonstrated that silencing MSC-AS1 inhibited OS biological behaviors by enhancing miR-142 to decrease CDK6 and inactivating the PI3K/AKT axis. Our results may provide new insights for OS treatment. PMID: 32155139 [PubMed - as supplied by publisher] (Source: Medical Science Monitor)
Source: Medical Science Monitor - March 11, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Zingerone Promotes Osteoblast Differentiation Via MiR-200c-3p/smad7 Regulatory Axis in Human Bone Mesenchymal Stem Cells.
CONCLUSIONS ZG contributed to osteoblast differentiation via miR-200c-3p/smad7 regulatory axis by promoting the expression of ALP, OC, OSX, and RUNX2 in hBMSCs. PMID: 32146478 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - March 10, 2020 Category: Research Tags: Med Sci Monit Source Type: research

miR-18a Inhibitor Suppresses Leukemia Cell Proliferation by Upregulation of PTEN Expression.
Authors: Zhang L, Kong L, Yang Y Abstract BACKGROUND Leukemia is common in aging adults and has very high mortality worldwide. The present study was designed to investigate the therapeutic efficacy of miR-18a inhibitor against WEHI-3 and THP-1 leukemia cells. MATERIAL AND METHODS The changes in miR-18a inhibitor-transfected WEHI-3 and THP-1 cell proliferative potential was measured by use of the Cell Counting Kit-8 assay. Apoptotic changes were analyzed by electron microscopy, and evaluation of PI3K, AKT, mTOR, and PTEN expression was assessed by RT-qPCR assay. RESULTS Transfection of miR-18a inhibitor significantly (P
Source: Medical Science Monitor - March 10, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Long Non-Coding RNA Taurine Upregulated Gene 1 (TUG1) Downregulation Constrains Cell Proliferation and Invasion through Regulating Cell Division Cycle 42 (CDC42) Expression Via MiR-498 in Esophageal Squamous Cell Carcinoma Cells.
Authors: Wang Z, Liu J, Wang R, Wang Q, Liang R, Tang J Abstract BACKGROUND Esophageal squamous cell carcinoma (ESCC) is a malignant tumor of the gastrointestinal tract. Taurine upregulated gene 1 (TUG1), a long non-coding (lnc) RNA, also known as LIN00080 or TI-227H, was connected with the tumorigenesis of various diseases. Hence, we plumed the role and molecular mechanism of TUG1 in the progression of ESCC. MATERIAL AND METHODS Expression patterns of TUG1, microRNA-498 (miR-498), and cell division cycle 42 (CDC42) mRNA were assessed using quantitative real time polymerase chain reaction (qRT-PCR). The expression ...
Source: Medical Science Monitor - March 8, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Identification of 2 Potential Core Genes for Influence of Gut Probiotics on Formation of Intracranial Aneurysms by Bioinformatics Analysis.
CONCLUSIONS Our study suggests that MYH11 and CAV1 are potential target genes for prevention of aneurysms. Further experiments are needed to verify these findings. PMID: 32141441 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - March 8, 2020 Category: Research Tags: Med Sci Monit Source Type: research

The Association Between MUC5B Mutations and Clinical Outcome in Patients with Rheumatoid Arthritis-Associated Interstitial Lung Disease: A Retrospective Exploratory Study in China.
CONCLUSIONS The carrier status of MUC5B variants was an indicator of reduced prognosis and increased exacerbations of RA-ILD. PMID: 32142504 [PubMed - as supplied by publisher] (Source: Medical Science Monitor)
Source: Medical Science Monitor - March 8, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Research Progress in Liver-Regenerating Microenvironment and DNA Methylation in Hepatocellular Carcinoma: The Role of Traditional Chinese Medicine.
Authors: Wang M, Ye Q, Mao D, Li H Abstract The development, progression, recurrence, and metastasis of hepatocellular carcinoma (HCC) are closely associated with an abnormal liver-regenerating microenvironment (LRM). Therefore, preventing and reversing an abnormal LRM is a potential therapeutic strategy against HCC. Studies are increasingly focusing on the impact of regeneration, fibrosis, angiogenesis, inflammation, immunomodulation, and hepatic stem cells on HCC development and progression. As a key epigenetic mechanism, DNA methylation is extensively involved in regulating physiological and pathological pathway...
Source: Medical Science Monitor - March 8, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Drug-Induced Liver Injury from Anti-Tuberculosis Treatment: A Retrospective Cohort Study.
Authors: Zhao H, Wang Y, Zhang T, Wang Q, Xie W Abstract BACKGROUND The aim of this study was to investigate the clinical characteristics and the risk factors associated with anti-tuberculosis (anti-TB) drug-induced liver injury (DILI). MATERIAL AND METHODS This retrospective study enrolled 140 hospitalized patients diagnosed with anti-TB DILI during January 2009 to December 2015. We assessed the baseline characteristics and performed regular follow-up up to the 24th week to assess the possible risk factors associated with the condition. RESULTS The study population was 58.6% male and 41.4% female patients; 20.7% w...
Source: Medical Science Monitor - March 8, 2020 Category: Research Tags: Med Sci Monit Source Type: research

The Effects of Social Support on Sleep Quality of Medical Staff Treating Patients with Coronavirus Disease 2019 (COVID-19) in January and February 2020 in China.
CONCLUSIONS SEM showed that medical staff in China who were treating patients with COVID-19 infection during January and February 2020 had levels of anxiety, stress, and self-efficacy that were dependent on sleep quality and social support. PMID: 32132521 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - March 7, 2020 Category: Research Tags: Med Sci Monit Source Type: research

A New Individualized Three-Dimensional Printed Template for Lateral Ankle Ligament Reconstruction.
CONCLUSIONS Both the template technique and the conventional method provided satisfactory outcomes for CLAI patients. However, the shorter operation duration and low number of radiation exposures in the template cohort suggest it is the better alternative for treatment of CLAI. PMID: 32134048 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - March 7, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Frequency and Pathophysiology of Post-Seizure Todd's Paralysis.
Authors: Xu SY, Li ZX, Wu XW, Li L, Li CX Abstract Todd's paralysis, a neurological abnormality characterized by temporary limb weakness or hemiplegia, typically occurs following a seizure, without enduring consequences. Since limb weakness or hemiplegia can also be a common symptom of an acute ischemic stroke, it is often difficult to diagnose Todd's paralysis in individuals experiencing an acute ischemic stroke if they do not have a pre-existing history of epilepsy. Given that there is a limited understanding of Todd's paralysis, this review discusses the history, prevalence, clinical manifestations, duration, et...
Source: Medical Science Monitor - March 7, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Establishment and Simulation of 3D Geometric Models of Mini-Pig and Sheep Knee Joints Using Finite Element Analysis.
CONCLUSIONS Our three-dimensional finite element analysis indicated that the mini-pig knee joint had stress values and changes of cartilage, meniscus, and peripheral ligaments that were similar to those of the human knee. PMID: 32123154 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - March 5, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Promotion of G1/S Transition and Inhibition of Inflammatory Cytokine Production by Hydroxypyridinone-Coumarin in Osteoarthritis Rats.
Authors: Yang K, Chen G, Wang X Abstract BACKGROUND Osteoarthritis is a joint disorder characterized by articular cartilage degradation leading to joint stiffness and pain. The present study investigated the effect of hydroxypyridinone-coumarin on proliferation of chondrocytes. MATERIAL AND METHODS Chondrocyte proliferation was assessed by MTT assay, and distribution of cells in various phases of the cell cycle was determined using flow cytometry. RT-PCR and Western blot assays were used for assessment of mRNA and protein levels, respectively. Osteoarthritis was induced in the rats by injecting monosodium iodoaceta...
Source: Medical Science Monitor - March 5, 2020 Category: Research Tags: Med Sci Monit Source Type: research