Interleukin-37 Attenuates Lipopolysaccharide (LPS)-Induced Neonatal Acute Respiratory Distress Syndrome in Young Mice via Inhibition of Inflammation and Cell Apoptosis.
CONCLUSIONS The present results suggest that IL-37 protect against LPS-induced lung injury through inhibition of inflammation and apoptosis in lung tissue in an LPS-induced neonatal ARDS model. Hence, IL-37 may be considered as a potential therapeutic agent for neonatal ARDS. PMID: 32152260 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - March 11, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Analysis of Masticatory Muscle Activity Based on Presence of Temporomandibular Joint Disorders.
This study was conducted to analyze the activity of masticatory muscles depending on the presence of temporomandibular joint disorders (TMD) when foods of various hardness are masticated. MATERIAL AND METHODS We enrolled 20 subjects (13 men and 7 women) who met our selection criteria, and they were divided into 3 groups (the Disorder Group, the Malalignment Group, and the Control Group) based on surveys and screening inspection. The average of reference voluntary contraction (RVC) was used to measure masticatory muscle activity. Using surface electromyography (SEMG) for each group during masticatory activity, the activitie...
Source: Medical Science Monitor - March 11, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Downregulated Long Non-Coding RNA MSC-AS1 Inhibits Osteosarcoma Progression and Increases Sensitivity to Cisplatin by Binding to MicroRNA-142.
CONCLUSIONS Our study demonstrated that silencing MSC-AS1 inhibited OS biological behaviors by enhancing miR-142 to decrease CDK6 and inactivating the PI3K/AKT axis. Our results may provide new insights for OS treatment. PMID: 32155139 [PubMed - as supplied by publisher] (Source: Medical Science Monitor)
Source: Medical Science Monitor - March 11, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Zingerone Promotes Osteoblast Differentiation Via MiR-200c-3p/smad7 Regulatory Axis in Human Bone Mesenchymal Stem Cells.
CONCLUSIONS ZG contributed to osteoblast differentiation via miR-200c-3p/smad7 regulatory axis by promoting the expression of ALP, OC, OSX, and RUNX2 in hBMSCs. PMID: 32146478 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - March 10, 2020 Category: Research Tags: Med Sci Monit Source Type: research

miR-18a Inhibitor Suppresses Leukemia Cell Proliferation by Upregulation of PTEN Expression.
Authors: Zhang L, Kong L, Yang Y Abstract BACKGROUND Leukemia is common in aging adults and has very high mortality worldwide. The present study was designed to investigate the therapeutic efficacy of miR-18a inhibitor against WEHI-3 and THP-1 leukemia cells. MATERIAL AND METHODS The changes in miR-18a inhibitor-transfected WEHI-3 and THP-1 cell proliferative potential was measured by use of the Cell Counting Kit-8 assay. Apoptotic changes were analyzed by electron microscopy, and evaluation of PI3K, AKT, mTOR, and PTEN expression was assessed by RT-qPCR assay. RESULTS Transfection of miR-18a inhibitor significantly (P
Source: Medical Science Monitor - March 10, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Long Non-Coding RNA Taurine Upregulated Gene 1 (TUG1) Downregulation Constrains Cell Proliferation and Invasion through Regulating Cell Division Cycle 42 (CDC42) Expression Via MiR-498 in Esophageal Squamous Cell Carcinoma Cells.
Authors: Wang Z, Liu J, Wang R, Wang Q, Liang R, Tang J Abstract BACKGROUND Esophageal squamous cell carcinoma (ESCC) is a malignant tumor of the gastrointestinal tract. Taurine upregulated gene 1 (TUG1), a long non-coding (lnc) RNA, also known as LIN00080 or TI-227H, was connected with the tumorigenesis of various diseases. Hence, we plumed the role and molecular mechanism of TUG1 in the progression of ESCC. MATERIAL AND METHODS Expression patterns of TUG1, microRNA-498 (miR-498), and cell division cycle 42 (CDC42) mRNA were assessed using quantitative real time polymerase chain reaction (qRT-PCR). The expression ...
Source: Medical Science Monitor - March 8, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Identification of 2 Potential Core Genes for Influence of Gut Probiotics on Formation of Intracranial Aneurysms by Bioinformatics Analysis.
CONCLUSIONS Our study suggests that MYH11 and CAV1 are potential target genes for prevention of aneurysms. Further experiments are needed to verify these findings. PMID: 32141441 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - March 8, 2020 Category: Research Tags: Med Sci Monit Source Type: research

The Association Between MUC5B Mutations and Clinical Outcome in Patients with Rheumatoid Arthritis-Associated Interstitial Lung Disease: A Retrospective Exploratory Study in China.
CONCLUSIONS The carrier status of MUC5B variants was an indicator of reduced prognosis and increased exacerbations of RA-ILD. PMID: 32142504 [PubMed - as supplied by publisher] (Source: Medical Science Monitor)
Source: Medical Science Monitor - March 8, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Research Progress in Liver-Regenerating Microenvironment and DNA Methylation in Hepatocellular Carcinoma: The Role of Traditional Chinese Medicine.
Authors: Wang M, Ye Q, Mao D, Li H Abstract The development, progression, recurrence, and metastasis of hepatocellular carcinoma (HCC) are closely associated with an abnormal liver-regenerating microenvironment (LRM). Therefore, preventing and reversing an abnormal LRM is a potential therapeutic strategy against HCC. Studies are increasingly focusing on the impact of regeneration, fibrosis, angiogenesis, inflammation, immunomodulation, and hepatic stem cells on HCC development and progression. As a key epigenetic mechanism, DNA methylation is extensively involved in regulating physiological and pathological pathway...
Source: Medical Science Monitor - March 8, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Drug-Induced Liver Injury from Anti-Tuberculosis Treatment: A Retrospective Cohort Study.
Authors: Zhao H, Wang Y, Zhang T, Wang Q, Xie W Abstract BACKGROUND The aim of this study was to investigate the clinical characteristics and the risk factors associated with anti-tuberculosis (anti-TB) drug-induced liver injury (DILI). MATERIAL AND METHODS This retrospective study enrolled 140 hospitalized patients diagnosed with anti-TB DILI during January 2009 to December 2015. We assessed the baseline characteristics and performed regular follow-up up to the 24th week to assess the possible risk factors associated with the condition. RESULTS The study population was 58.6% male and 41.4% female patients; 20.7% w...
Source: Medical Science Monitor - March 8, 2020 Category: Research Tags: Med Sci Monit Source Type: research

The Effects of Social Support on Sleep Quality of Medical Staff Treating Patients with Coronavirus Disease 2019 (COVID-19) in January and February 2020 in China.
CONCLUSIONS SEM showed that medical staff in China who were treating patients with COVID-19 infection during January and February 2020 had levels of anxiety, stress, and self-efficacy that were dependent on sleep quality and social support. PMID: 32132521 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - March 7, 2020 Category: Research Tags: Med Sci Monit Source Type: research

A New Individualized Three-Dimensional Printed Template for Lateral Ankle Ligament Reconstruction.
CONCLUSIONS Both the template technique and the conventional method provided satisfactory outcomes for CLAI patients. However, the shorter operation duration and low number of radiation exposures in the template cohort suggest it is the better alternative for treatment of CLAI. PMID: 32134048 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - March 7, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Frequency and Pathophysiology of Post-Seizure Todd's Paralysis.
Authors: Xu SY, Li ZX, Wu XW, Li L, Li CX Abstract Todd's paralysis, a neurological abnormality characterized by temporary limb weakness or hemiplegia, typically occurs following a seizure, without enduring consequences. Since limb weakness or hemiplegia can also be a common symptom of an acute ischemic stroke, it is often difficult to diagnose Todd's paralysis in individuals experiencing an acute ischemic stroke if they do not have a pre-existing history of epilepsy. Given that there is a limited understanding of Todd's paralysis, this review discusses the history, prevalence, clinical manifestations, duration, et...
Source: Medical Science Monitor - March 7, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Establishment and Simulation of 3D Geometric Models of Mini-Pig and Sheep Knee Joints Using Finite Element Analysis.
CONCLUSIONS Our three-dimensional finite element analysis indicated that the mini-pig knee joint had stress values and changes of cartilage, meniscus, and peripheral ligaments that were similar to those of the human knee. PMID: 32123154 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - March 5, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Promotion of G1/S Transition and Inhibition of Inflammatory Cytokine Production by Hydroxypyridinone-Coumarin in Osteoarthritis Rats.
Authors: Yang K, Chen G, Wang X Abstract BACKGROUND Osteoarthritis is a joint disorder characterized by articular cartilage degradation leading to joint stiffness and pain. The present study investigated the effect of hydroxypyridinone-coumarin on proliferation of chondrocytes. MATERIAL AND METHODS Chondrocyte proliferation was assessed by MTT assay, and distribution of cells in various phases of the cell cycle was determined using flow cytometry. RT-PCR and Western blot assays were used for assessment of mRNA and protein levels, respectively. Osteoarthritis was induced in the rats by injecting monosodium iodoaceta...
Source: Medical Science Monitor - March 5, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Perioperative Continuous Femoral Nerve Block Reduces Postoperative Cognitive Dysfunction of High-Risk Patients with Femoral Neck Fracture: Evidence from a Retrospective Propensity-Matched Study.
CONCLUSIONS For patients undergoing femoral neck fracture surgery, perioperative cFNB administration is useful in decreasing the incidence of POCD, especially for high-risk patients with a Mini-Cog score equal to or less than 2 points. PMID: 32126061 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - March 5, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Echocardiographic Analysis of Correlation Between Right Ventricle Load and Function and Left Ventricle Diastolic Malfunction in Symptomless Valvular Cardiovascular Disease Patients.
Authors: Guo Z, Chen G, Fu L, Zhang X Abstract BACKGROUND Left ventricle diastolic malfunction (LVDMf) is a valvular cardiovascular disease. Here, we assessed the correlation between right ventricle (RV) load and function (L&F) and diastolic malfunction (DMf) in symptomless valvular cardiovascular disease patients. MATERIAL AND METHODS We enrolled 59 subjects who underwent right-heart catheterization, assessing their echocardiographic analysis results while performing exercises in supine position, comparing results at rest and during maximum exercise. Subjects were furthermore stratified according to resting DM...
Source: Medical Science Monitor - March 5, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Altered Mitochondrial Dynamics, Biogenesis, and Functions in the Paclitaxel-Resistant Lung Adenocarcinoma Cell Line A549/Taxol.
CONCLUSIONS Our study revealed a series changes of mitochondrial characteristics in paclitaxel-resistant cells. Mfn1 and Mfn2 and PGC-1alpha increased, while Fis1 expression and mitochondrial oxidative phosphorylation decreased in A549/Taxol cell lines. These changes to mitochondrial fusion, fission, and biological function contributed to the occurrence of paclitaxel resistance in tumor cells which induced paclitaxel resistance. PMID: 32129321 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - March 5, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Exploration of the Molecular Mechanism of FUZI (Aconiti Lateralis Radix Praeparata) in Allergic Rhinitis Treatment Based on Network Pharmacology.
Authors: Chen X, Wang R, Meng W, Zhang X Abstract FUZI (Aconiti Lateralis Radix Praeparata) is a traditional Chinese medicine herb used extensively for nourishing yang (regarded as the positive, male universal force), which is critical in treatment of allergic rhinitis. In this paper, FUZI was explored based on network pharmacology. The active components of FUZI were screened out, its protein targets were assessed, and the protein interaction network map was built with the differential protein of allergic rhinitis, as an attempt to determine the critical targets of FUZI for treating allergic rhinitis. Subsequently,...
Source: Medical Science Monitor - March 4, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Compound Porcine Cerebroside and Ganglioside Injection (CPCGI) Attenuates Sevoflurane-Induced Nerve Cell Injury by Regulating the Phosphorylation of p38 MAP Kinase (p38MAPK)/Nuclear Factor kappa B (NF- κB) Pathway.
CONCLUSIONS We demonstrated the neuroprotective role of CPCGI in sevoflurane-stimulated neuronal cell damage via regulation of the MAPK/NF-kappaB signaling pathway. PMID: 32114591 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - March 4, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Propofol Reduces Epithelial to Mesenchymal Transition, Invasion and Migration of Gastric Cancer Cells through the MicroRNA-195-5p/Snail Axis.
CONCLUSIONS Our study found that propofol could inhibit EMT, invasion, and migration of GC cells by promoting miR-195-5p expression and suppressing Snail expression. This study may provide novel insights in GC treatment. PMID: 32115570 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - March 4, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Spalt-Like Protein 4 (SALL4) Promotes Angiogenesis by Activating Vascular Endothelial Growth Factor A (VEGFA) Signaling.
CONCLUSIONS In conclusion, these results support that by promoting proliferation, cell cycle progression, migration, and tube formation, SALL4 is involved in the process of angiogenesis through modulating VEGFA expression. PMID: 32116289 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - March 4, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Downregulation of miR-33 Has Protective Effect Against A β₂₅₋₃₅-Induced Injury in SH-SH-SY5Y Cells.
CONCLUSIONS Taken together, these findings suggest that miR-33 knockdown protects against Aß₂₅₋₃₅-induced inflammation, oxidative stress, apoptosis, and synaptic damage by suppressing activation of the Akt/mTOR pathway. PMID: 32119650 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - March 4, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Cumulative Sum Analysis of the Operator Learning Curve for Robot-Assisted Mayo Clinic Level I-IV Inferior Vena Cava Thrombectomy Associated with Renal Carcinoma: A Study of 120 Cases at a Single Center.
This study aimed to use cumulative sum analysis of the operator learning curve for robot-assisted Mayo Clinic level I-IV inferior vena cava (IVC) thrombectomy associated with renal carcinoma, and describes the development of an optimized operative procedure at a single center. MATERIAL AND METHODS A retrospective study included 120 patients with Mayo Clinic level I-IV IVC thrombus who underwent robotic surgery between 2013 and 2018. Points in the learning curve were identified using cumulative sum analysis, and their impact was assessed by multiple regression analysis. Perioperative indicators analyzed included operative t...
Source: Medical Science Monitor - March 1, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Curcumin Suppresses Apoptosis and Inflammation in Hypoxia/Reperfusion-Exposed Neurons via Wnt Signaling Pathway.
CONCLUSIONS Curcumin exerted neuro-protective effects against H/R-induced neuron apoptosis and inflammation by inhibiting activation of the Wnt/JNK1 signaling pathway. PMID: 32107363 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - March 1, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Synaptotagmin 12 (SYT12) Gene Expression Promotes Cell Proliferation and Progression of Lung Adenocarcinoma and Involves the Phosphoinositide 3-Kinase (PI3K)/AKT/Mammalian Target of Rapamycin (mTOR) Pathway.
CONCLUSIONS Bioinformatics analysis, human LUAD cells, and mouse xenograft studies showed that SYT12 acted as a possible oncogene by phosphorylation of PIK3R3 to activate the PI3K/AKT/mTOR signaling pathway. PMID: 32108133 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - March 1, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Analysis of Risk Factors for Anorectal Stenosis of Perianal Fistulizing Crohn's Disease.
CONCLUSIONS Higher CDAI and older age at diagnosis appear to confer higher risk of anorectal stenosis associated with PFCD. PMID: 32109226 [PubMed - as supplied by publisher] (Source: Medical Science Monitor)
Source: Medical Science Monitor - March 1, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Assessment of Acute Pulmonary Embolism by Computer-Aided Technique: A Reliability Study.
This study aimed to evaluate the reliability of geometry-based computer-aided detection and quantification for emboli morphology and severity of acute pulmonary embolism. MATERIAL AND METHODS Thirty patients suspected of acute pulmonary embolism were analyzed by both manual and computer-aided interpretation of vascular obstruction index and computer-aided measurements of emboli quantitative parameters. The reliability of Qanadli and Mastora scores was analyzed using computer-aided and manual interpretation. RESULTS The time costs of manual and computer-aided interpretation were statistically different (374.90±150.16...
Source: Medical Science Monitor - March 1, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Regenerative Potential of Menstrual Blood-Derived Stem Cells and Platelet-Derived Growth Factor in Endometrial Injury.
CONCLUSIONS These results suggest that MenSCs and PDGF may be candidate substances for endometrial injury repair. PMID: 32112554 [PubMed - as supplied by publisher] (Source: Medical Science Monitor)
Source: Medical Science Monitor - March 1, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Dihydrotanshinone I Alleviates Spinal Cord Injury via Suppressing Inflammatory Response, Oxidative Stress and Apoptosis in Rats.
CONCLUSIONS In conclusion, the findings suggest that DI alleviates SCI by restraining secretion of inflammatory factors, and occurrence of oxidative stress and apoptosis in vivo. DI may be developed into an effective alternative therapy for SCI in clinic. PMID: 32112706 [PubMed - as supplied by publisher] (Source: Medical Science Monitor)
Source: Medical Science Monitor - March 1, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Association of Obesity Measures with Atrial Fibrillation Recurrence After Cryoablation in Patients with Paroxysmal Atrial Fibrillation.
This study explored the relationship between various obesity indexes and risk of recurrence after cryoablation of paroxysmal AF (PAF). MATERIAL AND METHODS Our prospective study included 100 patients with PAF who underwent first cryoablation. Physical examination and fasting blood lipids levels were measured at baseline. Seven obesity indexes were determined: body mass index (BMI), waist circumference (WC), waist-to-height ratio (WHtR), waist-hip ratio (WHR), cardiometabolic index (CMI), lipid accumulation product (LAP), and body adiposity index (BAI). AF recurrence was confirmed by electrocardiograms and Holter monitor at...
Source: Medical Science Monitor - February 29, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Construction for Long Non-Coding RNA (lncRNA)-Associated Competing Endogenous RNA (ceRNA) Network in Human Retinal Detachment (RD) with Proliferative Vitreoretinopathy (PVR).
Authors: Yao K, Yu Y, Zhang H Abstract BACKGROUND The aim of this study was to analyze the long non-coding RNA (lncRNA)-associated competing endogenous RNA (ceRNA) network in human retinal tissues following detachment with proliferative vitreoretinopathy (PVR). MATERIAL AND METHODS Expression data of 19 human detached retinas with PVR and 19 normal retinas from postmortem donors were downloaded from Gene Expression Omnibust (GEO) database (GSE28133). The R package "limma" was utilized to discriminate the dysregulated lncRNA and mRNA profiles. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes ...
Source: Medical Science Monitor - February 29, 2020 Category: Research Tags: Med Sci Monit Source Type: research

The Comparison of the Biological Rhythms of Patients with Fibromyalgia Syndrome with Biological Rhythms of Healthy Controls.
Authors: Bulbul F, Koca I, Savas E, Dokuyucu R Abstract BACKGROUND Fibromyalgia syndrome (FMS) is a rheumatic disease characterized by diffuse body pain and decreased muscle function. The aim of the present study was to compare the biological rhythms of patients with fibromyalgia syndrome with the biological rhythms of healthy controls. MATERIAL AND METHODS This was a cross-sectional, single blind, and single center case-control study. The patients with fibromyalgia were evaluated using a Fibromyalgia Impact Questionnaire (FIQ), Biological Rhythms Interview of Assessment in Neuropsychiatry (BRIAN) Scale, Visual Ana...
Source: Medical Science Monitor - February 27, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Intermittent Splenic Artery Occlusion Plus Gauze Compression Is a Simple and Effective Treatment for Iatrogenic Splenic Injury.
CONCLUSIONS Intermittent splenic artery occlusion plus gauze compression is a simple and effective treatment for iatrogenic splenic injury. PMID: 32096484 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - February 27, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Economic Analysis of Surgical and Interventional Treatments for Patients with Complex Coronary Artery Disease: Insights from a One-Year Single-Center Study.
Authors: Zhao Y, Meng S, Liu T, Dong R Abstract BACKGROUND Surgical treatment methods for patients with complex coronary artery disease (CAD) who have undergone vascular reconstruction mainly include coronary artery bypass graft (CABG) and percutaneous coronary intervention (PCI). The purpose of the study aimed to compare a 1-year follow-up for the patient clinical outcomes and costs between PCI and CABG treatment. MATERIAL AND METHODS There were 840 patients enrolled in this study from July 2015 to September 2016. Among the study participants, 420 patients underwent PCI treatment and 420 patients underwent off-pum...
Source: Medical Science Monitor - February 27, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Identification and Validation of a Potent Multi-miRNA Signature for Prediction of Prognosis of Osteosarcoma Patients.
CONCLUSIONS The 3-miRNA-based classifier serves as an effective prognosis-predicting signature for osteosarcoma patients. PMID: 32098942 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - February 27, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Emergent Double Balloon Enteroscopy in Overt Suspected Small Bowel Bleeding: Diagnosis and Therapy.
Authors: Yin A, Zhao L, Ding Y, Yu H Abstract BACKGROUND Double balloon enteroscopy (DBE) is a diagnosis and therapy method for suspected small bowel bleeding (SSBB). The data for emergent DBE is limited in overt SSBB cases. The aim of this study was to investigate the role of diagnosis and therapy of emergent DBE in patients with overt SSBB. MATERIAL AND METHODS The clinical and endoscopic data for patients with overt SSBB undergoing DBE in a single center from January 2010 to December 2017 were collected and analyzed. Emergent DBE was defined as DBE performed less than 3 days of last bleeding onset. RESULTS A tot...
Source: Medical Science Monitor - February 27, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Correlation Between Sex and Facial Soft Tissue Characteristics Among Young Saudi Patients with Various Orthodontic Skeletal Malocclusions.
Authors: Ajwa N, Alkhars FA, AlMubarak FH, Aldajani H, AlAli NM, Alhanabbi AH, Alsulaiman SA, Divakar DD Abstract BACKGROUND There is a debate over the influence of sex on facial soft tissue physiognomies. Therefore, the present study used teleradiographs to assess and compare the soft tissue physiognomies between males and females in a sample from Saudi Arabia who have various orthodontic malocclusions. MATERIAL AND METHODS We obtained 221 lateral cephalometric radiographs taken from orthodontic clinics of patients ages 16-26 years (114 males and 107 females) living in the central and eastern regions of Saudi Arab...
Source: Medical Science Monitor - February 27, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Immune Response of Plasmacytoid Dendritic Cells Stimulated by Human Papillomavirus (HPV) E6 in an In Vitro System.
CONCLUSIONS The expression of MyD88 and TRAF6 might vary in different stages of HPV infection. pDCs might regulate CD40 to participate in the tumorigenesis and progression of cervical cancer, but related mechanisms still need further investigation. PMID: 32089541 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - February 26, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Angiogenic Factor with G Patch and FHA Domains 1 (AGGF1) Acts as Diagnostic Biomarker and Adverse Prognostic Factor of Hepatocellular Carcinoma (HCC): Evidence from Bioinformatic Analysis.
CONCLUSIONS AGGF1 was a potential diagnostic and prognostic marker for poor clinical outcomes in HCC patients. Moreover, vital pathways regulated by AGGF1 in HCC may include regulation of autophagy, Wnt signaling pathway, pathway in cancer, cell cycle, and P53 signaling pathway. PMID: 32090983 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - February 26, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Effect of Pressure-Controlled Ventilation-Volume Guaranteed on One-Lung Ventilation in Elderly Patients Undergoing Thoracotomy.
CONCLUSIONS Compared with VCV, PCV-VG mode reduced airway pressure in patients undergoing thoracotomy and also decreased the release of NE and reduced inflammatory response and lung injury. We conclude that PCV-VG mode can protect the lung function of elderly patients undergoing thoracotomy. PMID: 32092047 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - February 26, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Relationship of CARD8 Gene Polymorphisms with Susceptibility to Ankylosing Spondylitis: A Case-Control Study.
CONCLUSIONS CARD8 polymorphisms are likely to be associated with the elevated susceptibility of AS. Present results should be confirmed in the future studies. PMID: 32080163 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - February 24, 2020 Category: Research Tags: Med Sci Monit Source Type: research

A Network Pharmacology Approach to Estimate the Active Ingredients and Potential Targets of Cuscutae semen in the Treatment of Osteoporosis.
CONCLUSIONS This study suggested that CS has multiple ingredients and multiple targets relevant to the treatment of osteoporosis. We determined that the active ingredient, sesamin, may be the most crucial ingredient of CS for the treatment of osteoporosis. Additionally, the network pharmacology method provided a novel research approach to analyze the function of complex ingredients. PMID: 32081843 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - February 24, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Overexpression of Bone Morphogenetic Protein-1 Promotes Osteogenesis of Bone Marrow Mesenchymal Stem Cells In Vitro.
CONCLUSIONS Our results suggest that the overexpression of BMP-1 can promote the osteogenesis of BMSCs and provides an improved method of cell-based tissue engineering. PMID: 32084123 [PubMed - as supplied by publisher] (Source: Medical Science Monitor)
Source: Medical Science Monitor - February 24, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Comparative Evaluation of Two Antioxidants on Reversing the Immediate Bond Strength of Bleached Enamel: In Vitro Study.
CONCLUSIONS 10% sodium ascorbate provided a comparatively more promising improvement for immediate bond strength than 5% proanthocyanidins when the same duration of antioxidant was applied. PMID: 32086431 [PubMed - as supplied by publisher] (Source: Medical Science Monitor)
Source: Medical Science Monitor - February 24, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Expression and Prognostic Significance of m6A-Related Genes in Lung Adenocarcinoma.
CONCLUSIONS m6A-related genes were differentially expressed in LUAD compared to matched normal patients. The m6A-related genes METTL3, YTHDF1, and YTHDF2 could serve as novel biomarkers for the prognosis of LUAD. PMID: 32086933 [PubMed - as supplied by publisher] (Source: Medical Science Monitor)
Source: Medical Science Monitor - February 24, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Maternal Characteristics and Obstetric and Neonatal Outcomes of Singleton Pregnancies Among Adolescents.
CONCLUSIONS In conclusion, our findings indicate that along with considerably high rates of poor antenatal care, maternal anemia and cesarean delivery, adolescent pregnancies were also associated with high rates for fetal distress at birth, preterm delivery, and NICU re-admission within post-discharge 1-month. PMID: 32087083 [PubMed - as supplied by publisher] (Source: Medical Science Monitor)
Source: Medical Science Monitor - February 24, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Retracted: Modified Closing-Opening Wedge Osteotomy to Correct Kyphosis in Ankylosing Spondylitis.
Authors: Feng C, Tao H, Yang K, Xu J, Duan C, Yang W, Li H, Li H Abstract An Editorial decision has been made to retract the manuscript, Feng C, et al. Modified Closing-Opening Wedge Osteotomy to Correct Kyphosis in Ankylosing Spondylitis. Med Sci Monit. 2019; 25:6532-6538. It has come to our attention that the method of modified closing opening wedge osteotomy is not an original procedure developed by the authors, but has previously been described by Boissière L, et al. Spine J. 2015;15(12):2574-82, and Gao R, et al. Spine J. 2015;15(9):2009-15, and Boachie-Adjei O, et al. Spine (Phila Pa 1976). 2006;31(4):...
Source: Medical Science Monitor - February 24, 2020 Category: Research Tags: Med Sci Monit Source Type: research

High Expression of Methylenetetrahydrofolate Dehydrogenase 2 (MTHFD2) in Esophageal Squamous Cell Carcinoma and its Clinical Prognostic Significance.
Authors: He H, Li PC, Jia W, Hu B, Ji CS Abstract BACKGROUND Recently, targeted therapy for malignant tumors has developed rapidly, but there is still no effective targeted therapy for advanced esophageal squamous cell carcinoma (ESCC). Methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) is a key enzyme involved in folate metabolism and is closely related to the proliferation in many cancers. However, few studies have explored the expression of MTHFD2 in ESCC and its prognostic significance. MATERIAL AND METHODS The expressions of MTHFD2, ki67, and p53 in ESCC tissues were detected by immunohistochemistry. Further, ...
Source: Medical Science Monitor - February 24, 2020 Category: Research Tags: Med Sci Monit Source Type: research

A Nomogram for Individual Prediction of Poor Prognosis After Radical Surgery in Patients with Primary Pancreatic Duct Adenocarcinoma.
CONCLUSIONS Our study presents a valid and practical model to predict prognosis of pancreatic cancer patients, which contributes to individualized therapy by assisting surgeons to predict poor prognosis in patients who received radical surgery. PMID: 32088726 [PubMed - as supplied by publisher] (Source: Medical Science Monitor)
Source: Medical Science Monitor - February 24, 2020 Category: Research Tags: Med Sci Monit Source Type: research