Knockdown of Long Non-Coding RNA (lncRNA) Colon Cancer-Associated Transcript-1 (CCAT1) Suppresses Oral Squamous Cell Carcinoma Proliferation, Invasion, and Migration by Inhibiting the Discoidin Domain Receptor 2 (DDR2)/ERK/AKT Axis.
CONCLUSIONS Downregulation of CCAT1 suppressed TCA-8113 cell proliferation, invasion, and migration by inactivation of the ERK/AKT pathway via inhibition of DDR2, suggesting the value of CCAT1 in diagnosis and treatment of patients with OSCC. PMID: 32009633 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - February 6, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Inhibition of NADPH Oxidase 5 (NOX5) Suppresses High Glucose-Induced Oxidative Stress, Inflammation and Extracellular Matrix Accumulation in Human Glomerular Mesangial Cells.
CONCLUSIONS Taken together, these findings demonstrated that inhibition of NOX5 attenuated HG-induced HMCs oxidative stress, inflammation, and ECM accumulation, suggesting that NOX5 may serve as a potential therapeutic target for diabetic nephropathy (DN) treatment. PMID: 32012145 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - February 6, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Age-Related Decline in Renal Blood Flow Could Be a Beneficial and Compensatory Mechanism.
Authors: Czarkowska-Pączek B, Mucha K, Pączek L Abstract Aging is a time-dependent process affecting all organs and tissues in the human body. The process of aging in the kidney is characterized by structural and functional changes, of which the main feature is a reduction in size, a decreased number of functioning glomeruli, and vascular changes. These changes result in functional deterioration, mainly involving a decrease in renal blood flow and the glomerular filtration rate. Additionally, impaired regulation of electrolyte and water homeostasis due to structural changes in the tubulo-interstitial system can o...
Source: Medical Science Monitor - February 6, 2020 Category: Research Tags: Med Sci Monit Source Type: research

A Retrospective Study to Compare the Efficacy of Preoperative Halo-Gravity Traction and Postoperative Halo-Femoral Traction After Posterior Spinal Release in Corrective Surgery for Severe Kyphoscoliosis.
CONCLUSIONS Patients with severe kyphoscoliosis who underwent postoperative halo-femoral traction after posterior spinal release achieved satisfactory radiographic correction. PMID: 32015301 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - February 6, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Effect of Neotype Rectal Mild Hypothermia Therapy on Intestinal Bacterial Translocation in Rats with Hypoxic-Ischemic Brain Damage.
CONCLUSIONS The neotype rectal MH cooling method could be a potential strategy to induce rapid, controllable hypothermia, thus reducing the possibility of inflammatory cell infiltration and BT incidence. PMID: 32017761 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - February 6, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Histological Tumor Type is Associated with One-Year Cause-Specific Survival in Women with Stage III-IV Epithelial Ovarian Cancer: A Surveillance, Epidemiology, and End Results (SEER) Database Population Study, 2004-2014.
Authors: Wu SG, Li FY, Lei J, Hua L, He ZY, Zhou J Abstract BACKGROUND The prognosis of epithelial ovarian cancer (EOC) remains poor. Cause-specific survival (CSS) is an overall survival measure of cancer survival that excludes other causes of death. This retrospective population study used the Surveillance, Epidemiology, and End Results (SEER) database to evaluate prognostic factors associated with one-year CSS in women with stage III-IV EOC between 2004-2014. MATERIAL AND METHODS Data from the SEER program included a cohort of patients with stage III-IV EOC between 2004-2014. Binomial logistic regression analysis...
Source: Medical Science Monitor - February 4, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Bioinformatics Analysis Identifies Hub Genes and Molecular Pathways Involved in Sepsis-Induced Myopathy.
CONCLUSIONS Bioinformatics network analysis identified key hub genes and molecular mechanisms in SIM. PMID: 32008037 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - February 4, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Bauerane Induces S-Phase Cell Cycle Arrest, Apoptosis, and Inhibition of Proliferation of A549 Human Lung Cancer Cells Through the Phosphoinositide 3-Kinase (PI3K)/AKT and Signal Transducer and Activator of Transcription 3 (STAT3) Signaling Pathway.
CONCLUSIONS Bauerane inhibited the proliferation of A549 lung cancer cells in vitro and induced cell apoptosis and cell cycle arrest in a dose-dependent manner. PMID: 32005795 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - February 3, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Asiaticoside Alleviates Cerebral Ischemia-Reperfusion Injury via NOD2/Mitogen-Activated Protein Kinase (MAPK)/Nuclear Factor kappa B (NF- κB) Signaling Pathway.
CONCLUSIONS Asiaticoside showed a protective effect against cerebral ischemia-reperfusion injury via the NOD2/MAPK/NF-kappaB signaling pathway. These findings are vital for future research on use of asiaticoside in CIRI, providing a new avenue for alleviating CIRI. PMID: 32006420 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - February 3, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Changes in Serum Amyloid A (SAA) and 8-OHdG in Patients with Senile Early Cognitive Impairment.
This study assessed variations in SAA and 8-OHdG in patients with senile early cognitive impairment (CI). MATERIAL AND METHODS The subjects were divided into 3 groups: 121 patients with mild cognitive impairment (MCI), 131 with Alzheimer's disease (AD), and 100 healthy persons that underwent physical examinations during the same period (Control). These groups were evaluated by MMSE and MoCA, and the SAA and 8-OHdG levels in these groups were tested using ELISA sandwich technique. RESULTS The AD group had significantly higher TG and ApoB levels, followed by the MCI and Control groups, respectively (P
Source: Medical Science Monitor - February 3, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Comparison of Clinical Outcomes, Radiological Outcomes and Bone Remodeling Outcomes Between Proximal Coated Single-Wedge New Stem and Full Coated Dual-Wedge Classic Stem in 1-Stage Bilateral Total Hip Arthroplasty.
Authors: Hu H, Liu Z, Liu B, Ding X, Liu S, Wu T, Ma W, Han Y Abstract BACKGROUND This retrospective study investigated the clinical outcomes, radiological outcomes, and bone remodeling patterns associated with a Medial/Lateral Taper (M/L Taper) stem and Link Classic Uncemented (LCU) stem in 1-stage bilateral total hip arthroplasty (THA). MATERIAL AND METHODS The results of 52 patients who underwent 1-stage bilateral THA with a M/L Taper stem on one side and an LCU stem on the other between January 2012 and February 2015 were retrospectively compared. Patients were clinically assessed by the Harris hip score (HHS),...
Source: Medical Science Monitor - February 2, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Upregulation of the Coatomer Protein Complex Subunit beta 2 (COPB2) Gene Targets microRNA-335-3p in NCI-H1975 Lung Adenocarcinoma Cells to Promote Cell Proliferation and Migration.
CONCLUSIONS This study showed that COPB2 was the functional target of miR-335-3p in NCI-H1975 human adenocarcinoma cells. PMID: 32004259 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - February 2, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Evaluation of 2 Rat Models for Sepsis Developed by Improved Cecal Ligation/Puncture or Feces Intraperitoneal-Injection.
CONCLUSIONS Both modeling methods induced sepsis in rats and closely mimicked the clinical conditions, but FIP was easier to establish and was more suitable for standardization. PMID: 31992687 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - January 31, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Analysis of the Relationship Between Modic Change and Spinopelvic Parameters in the Sagittal Plane.
This study explored relationship between Modic change and spinopelvic parameters in the sagittal plane. MATERIAL AND METHODS We divided 80 patients into 4 groups: 60 subjects diagnosed with Modic changes (MC) were enrolled in the MC groups (MC1, MC2, and MC3) with each MC type consisting of 20 subjects, and 60 healthy subjects were enrolled in the control group. Spinopelvic parameters in the sagittal plane were calculated to assess their associations with MC. Multivariate logistic regression was used to explore possible risk factors for MC. RESULTS PI and LL in the MC groups were significant smaller than in the control group (p
Source: Medical Science Monitor - January 31, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Fetal and Maternal Responses to Dexmedetomidine Intrathecal Application During Cesarean Section: A Meta-Analysis.
CONCLUSIONS Intrathecal DEX is safe for the fetus during cesarean section and can improve the blockade effects of spinal anesthesia on puerperae. PMID: 31995551 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - January 31, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Osteopontin in Bone Metabolism and Bone Diseases.
Authors: Si J, Wang C, Zhang D, Wang B, Zhou Y Abstract Osteopontin (OPN), a secreted phosphoprotein, is a member of the small integrin-binding ligand N-linked glycoprotein (SIBLING) family of cell matrix proteins and participates in many biological activities. Studies have shown that OPN plays a role in bone metabolism and homeostasis. OPN not only is an important factor in neuron-mediated and endocrine-regulated bone mass, but also is involved in biological activities such as proliferation, migration, and adhesion of several bone-related cells, including bone marrow mesenchymal stem cells, hematopoietic stem cell...
Source: Medical Science Monitor - January 31, 2020 Category: Research Tags: Med Sci Monit Source Type: research

MicroRNA-668-3p Protects Against Oxygen-Glucose Deprivation in a Rat H9c2 Cardiomyocyte Model of Ischemia-Reperfusion Injury by Targeting the Stromal Cell-Derived Factor-1 (SDF-1)/CXCR4 Signaling Pathway.
CONCLUSIONS In the OGD rat H9c2 cardiomyocyte model of IRI, miR-668-3p suppressed mediators of inflammation and oxidative stress and enhanced cell viability through the SDF-1/CXCR4 signaling pathway. PMID: 31997826 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - January 31, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Protective Effect of Circular RNA (CircRNA) Ddx17 in Ovalbumin (OVA)-Induced Allergic Rhinitis (AR) Mice.
CONCLUSIONS CircDdx17 appears to have a protective effect on mice in the progression of AR. Specifically, overexpression of circDdx17 inhibited the expression of miR-17-5p and alleviated the condition of AR. Therefore, circDdx17 appears to be a good candidate for use in prevention of AR. However, the detailed mechanism underlying the circDdx17/miR-17-5p regulatory pathway requires further study. PMID: 31999672 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - January 31, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Posterior Vertebrectomy via the Unilateral Pedicle or Bilateral Pedicle Approach in the Treatment of Lumber Burst Fracture with Neurological Deficits: A Comparative Retrospective Cohort Study.
CONCLUSIONS UPA and BPA had a similar clinical performance for LBF. However, the shorter DO and lower BLV achieved in the UPA cohort suggested UPA is a better alternative for LBF. PMID: 31988273 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - January 30, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Related Network and Differential Expression Analyses Identify Nuclear Genes and Pathways in the Hippocampus of Alzheimer Disease.
CONCLUSIONS In this study, YWHAZ, DLG4, AGAP2, EGFR, TGFBR3, PSD3, RDX, and BRWD1 were identified as candidate genes for future molecular studies in AD, which is expected to improve our understanding of its cause and potential molecular mechanisms. Nuclear genes, DEGs, and related networks identified by integrated bioinformatics analysis may serve as diagnostic and therapeutic targets for AD. PMID: 31989994 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - January 30, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Downregulated miR-524-5p Participates in the Tumor Microenvironment of Ameloblastoma by Targeting the Interleukin-33 (IL-33)/Suppression of Tumorigenicity 2 (ST2) Axis.
In this study, we hypothesized that miR-524-5p could be involved in the tumor microenvironment by targeting interleukin-33 (IL-33)/suppression of tumorigenicity 2 (ST2) in AB. MATERIAL AND METHODS The microRNA (miRNA) expression profile of AB tissues and normal oral mucosa tissues (NOM; 6 paired samples) was analyzed. The miRNAs with fold change ≥2 and P
Source: Medical Science Monitor - January 30, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Needle-Guided Suture Technique for Lumbar Annular Fiber Closure in Microendoscopic Discectomy: A Technical Note and Case Series.
We present a novel suture method, needle-guided annular closure suture (NGACS) that does not require a special device and can be performed for annular fiber closure following microendoscopic discectomy. MATERIAL AND METHODS Twenty-five patients who underwent treatment with NGACS were reviewed by analysis of the medical records. The clinical outcomes were assessed and compared preoperatively and immediately, 1, 6, and 12 months postoperatively. The parameters included the Visual Analog Scale (VAS)-back and VAS-leg scores and the Oswestry Disability Index (ODI). Midsagittal T2WI images were obtained to evaluate lumbar disc d...
Source: Medical Science Monitor - January 28, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Echocardiographic Changes in Newly Diagnosed Type 2 Diabetes Mellitus Patients with and without Hypertension.
This study aimed to investigate echocardiographic features in patients with newly diagnosed T2DM, exploring changes in cardiac structure and function. MATERIAL AND METHODS This was a retrospective study of new T2DM cases treated at the Second People's Hospital Affiliated to Nanjing Medical University (Changzhou) in 2014-2016. In all, 128 T2DM cases were included (62 hypertensive and 66 non-hypertensive individuals). Controls were selected among individuals who underwent examination at the same department/period. Interventricular septal thickness (IVST), left ventricular end-diastolic diameter (LVEDD), posterior left ventri...
Source: Medical Science Monitor - January 28, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Ferulic Acid Induces Apoptosis of HeLa and Caski Cervical Carcinoma Cells by Down-Regulating the Phosphatidylinositol 3-Kinase (PI3K)/Akt Signaling Pathway.
This study aimed to investigate the effects of ferulic acid on HeLa and Caski human cervical carcinoma cells and the molecular mechanisms involved. MATERIAL AND METHODS HeLa and Caski human cervical carcinoma cells were grown in culture and treated with increasing doses of ferulic acid. The MTT assay was used to evaluate cell viability. Flow cytometry was performed with 4',6-diamidino-2-phenylindole (DAPI) and Annexin V staining for cell apoptosis. The expression of myeloid leukemia cell differentiation-1 (Mcl-1) protein and MCL-1 mRNA were determined by Western blot and reverse transcription-polymerase chain reaction (RT-...
Source: Medical Science Monitor - January 28, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Microarray Analysis of Differential Gene Expression in Alzheimer's Disease Identifies Potential Biomarkers with Diagnostic Value.
CONCLUSIONS We screened 379 significant DEGs as potential biomarkers of AD using PAM and obtained 32 hub genes through PPI network and module analysis. These findings reveal new potential AD biomarkers with prognostic and therapeutic value. PMID: 31984950 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - January 28, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Bacterial Lactase Gene Characteristics in Intestinal Contents of Antibiotic-Associated Diarrhea Mice Treated with Debaryomyces hansenii.
Authors: Wu Y, Tang Y, Xiao NQ, Wang CH, Tan ZJ Abstract BACKGROUND Debaryomyces hansenii exhibits a therapeutic effect on antibiotic-associated diarrhea (AAD) by promoting the growth of beneficial intestinal bacteria. Previous research has reported that AAD involves not only dysbacteriosis but also dysfunction of the activity of intestinal enzymes (such as lactase). Enzyme activities can be influenced by many other factors, such as gene expression. The present study showed that D. hansenii has a curative effect on AAD at the lactase gene level. MATERIAL AND METHODS The effect of D. hansenii on the lactase gene fro...
Source: Medical Science Monitor - January 28, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Sarcopenia Is Associated with Cognitive Decline and Falls but Not Hospitalization in Community-Dwelling Oldest Old in China: A Cross-Sectional Study.
CONCLUSIONS Our results showed that sarcopenia was significantly and independently associated with cognitive decline and falls, but not associated with hospitalization, in the community-dwelling oldest old. PMID: 31980594 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - January 27, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Sagittal Spinal and Pelvic Alignment in Middle-Aged and Older Men and Women in the Natural and Erect Sitting Positions: A Prospective Study in a Chinese Population.
CONCLUSIONS In the natural sitting position, a reduction in LL was associated with TK, SVA and PT increased, and there were differences between men and women. The characteristics of spinopelvic alignment in healthy older adults should be considered when planning corrective spinal surgery. PMID: 31981456 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - January 27, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Doxycycline Improves Fibrosis-Induced Abnormalities in Atrial Conduction and Vulnerability to Atrial Fibrillation in Chronic Intermittent Hypoxia Rats.
CONCLUSIONS The findings suggested that Doxy can profoundly mitigate atrial fibrosis, conduction inhomogeneity as well as high AF inducibility secondary to fibrosis in a CIH rat model through suppressing the TGF-ß1 signaling pathway. PMID: 31974331 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - January 25, 2020 Category: Research Tags: Med Sci Monit Source Type: research

NF- κB Phosphorylation Inhibition Prevents Articular Cartilage Degradation in Osteoarthritis Rats via 2-Aminoquinoline.
CONCLUSIONS The present study demonstrated that 2-aminoquinoline prevents articular cartilage damage in osteoarthritis rats through inhibition of inflammatory factors and downregulation of NF-kappaB activation, suggesting that 2-aminoquinoline would be effective in treatment of osteoarthritis. PMID: 31978040 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - January 25, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Trop2 Promotes Multidrug Resistance by Regulating Notch1 Signaling Pathway in Gastric Cancer Cells.
CONCLUSIONS Our findings suggest that Trop2 promotes the resistance of gastric cancer to chemotherapy by activating the Notch1 pathway. PMID: 31964857 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - January 24, 2020 Category: Research Tags: Med Sci Monit Source Type: research

A Competing Risk Analysis Study of Prognosis in Patients with Esophageal Carcinoma 2006-2015 Using Data from the Surveillance, Epidemiology, and End Results (SEER) Database.
Authors: Yu Z, Yang J, Gao L, Huang Q, Zi H, Li X Abstract BACKGROUND Competing risk analysis determines the probability of survival and considers competing events. This retrospective study aimed to undertake a competing risk analysis of prognosis in patients with esophageal carcinoma between 2006-2015 using data from the Surveillance, Epidemiology, and End Results (SEER) database. MATERIAL AND METHODS Clinicopathological, demographic, and survival data were analyzed for patients with esophageal carcinoma registered in the SEER database between 2006-2015. The competing risk model calculated the cumulative incidence...
Source: Medical Science Monitor - January 24, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Clinical Significance and Potential Regulatory Mechanisms of Serum Response Factor in 1118 Cases of Thyroid Cancer Based on Gene Chip and RNA-Sequencing Data.
CONCLUSIONS The reduction of SRF appears to play a crucial role in the origin of TC. These properties are accomplished by the target genes of SRF, as a transcription factor, or by the axes with the associated miRNAs. PMID: 31967986 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - January 24, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Development and Identification of a Nomogram Prognostic Model for Patients with Primary Clear Cell Carcinoma of the Liver.
CONCLUSIONS The prognosis of PCCCL resembled that of common-type HCC. Larger lesions, distant metastases, and enhanced AFP levels were associated with unsatisfactory prognosis. Surgery fulfill favorable prognosis while radiotherapy or chemotherapy exerted no significant effects on survival. PMID: 31969554 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - January 24, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Maternal Utero-Placental Perfusion Discordance in Monochorionic-Diamniotic Twin Pregnancies with Selective Growth Restriction Assessed by Three-Dimensional Power Doppler Ultrasound.
CONCLUSIONS MCDA twin pregnancies with birthweight discordance presented utero-placental perfusion deterioration assessed by 3DPD prior to sGR diagnosis. Co-twin utero-placental perfusion discordance was significantly correlated with growth discordance, and this correlation was more predictive of sGR when 3DPD was combined with conventional Doppler imaging. PMID: 31971163 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - January 24, 2020 Category: Research Tags: Med Sci Monit Source Type: research

The Lipoxin A4 Receptor Agonist BML-111 Alleviates Inflammatory Injury and Oxidative Stress in Spinal Cord Injury.
CONCLUSIONS BML-111 alleviated inflammation and oxidative stress in SCI rats. PMID: 31971927 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - January 24, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Add-On Effects of Conventional Synthetic Disease-Modifying Anti-Rheumatic Drugs in Ankylosing Spondylitis: Data from a Real-World Registered Study in China.
CONCLUSIONS Use of csDMARDs can improve disease activity in terms of ASDAS-CRP. The addition of csDMARDs may provide increased benefits compared with NSAID monotherapy, particularly in the reduction of AS disease activity, in the Chinese population. PMID: 31959738 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - January 23, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Propofol Inhibits Cell Proliferation, Migration, and Invasion via mir-410-3p/Transforming Growth Factor- β Receptor Type 2 (TGFBR2) Axis in Glioma.
CONCLUSIONS Propofol can suppress cell growth and metastasis by regulating the miR-410-3p/TGFBR2 axis in glioma. PMID: 31960827 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - January 23, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Direct Anterior Approach Versus Posterolateral Approach for Hemiarthroplasty in the Treatment of Displaced Femoral Neck Fractures in Geriatric Patients.
CONCLUSIONS Our study results suggest that early clinical and biochemical outcomes are better in DAA than PLA with early return to daily living activities in patients undergoing hemiarthroplasty for displaced femoral neck fractures. PMID: 31961830 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - January 23, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Mitofusin-2 (Mfn-2) Might Have Anti-Cancer Effect through Interaction with Transcriptional Factor SP1 and Consequent Regulation on Phosphatidylinositol Transfer Protein 3 (PITPNM3) Expression.
CONCLUSIONS Mfn-2 could suppress expression of PITPNM3 through interaction with transcription factor SP1; Mfn-2 may have anti-tumor activity; SP1 and PITPNM3 may promote tumor development. PMID: 31955176 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - January 21, 2020 Category: Research Tags: Med Sci Monit Source Type: research

MicroRNA-639 is Down-Regulated in Hepatocellular Carcinoma Tumor Tissue and Inhibits Proliferation and Migration of Human Hepatocellular Carcinoma Cells Through the KAT7/Wnt/ β-Catenin Pathway.
CONCLUSIONS miR-639 was down-regulated in HCC tumor tissue, and inhibited proliferation and migration of HCC cells by the down-regulation of KAT7/Wnt/ß-catenin signaling and was associated with reduced OS. These findings supported the potential role of miR-639 as a tumor suppressor. PMID: 31955177 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - January 21, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Khat Chewing Induces a Floral Shift in Dental Material-Associated Microbiota: A Preliminary Study.
CONCLUSIONS This research concluded that khat chewing significantly affects bacterial biodiversity in oral biofilms in the presence of different restorative and prosthetic dental materials. PMID: 31956260 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - January 21, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Expression of MiR-140 and MiR-199 in Synovia and its Correlation with the Progression of Knee Osteoarthritis.
Authors: Chao Y, Zhang L, Zhang X, Ma C, Chen Z Abstract BACKGROUND The aim of this study was to explore the expression of miR-140 and miR-199 in synovia of patients with knee osteoarthritis (KOA) and its correlation with the progression of this disease. We used the Kellgren and Lawrence grading (KLG) system. MATERIAL AND METHODS There were 110 patients with early (KLG 2) stage KOA and 60 healthy individuals (control) included in this study. RESULTS The relative expression levels of miR-140 (1.07±0.091) and miR-199 (1.03±0.110) in synovia of the control group were higher than those of KOA groups (0.51...
Source: Medical Science Monitor - January 21, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Measurement of the Combined Levels of Serum Uric Acid and Alanine Aminotransferase and the Risk of Metabolic Syndrome in a Population Aged 60 Years or More in Northeastern China.
This study aimed to investigate the association between the combined levels of SUA and ALT and the risk of metabolic syndrome in residents ≥60 years of age in Northeastern China. MATERIAL AND METHODS A population study included nine communities in Shenyang, Northeast China, and 3,998 participants (1,434 men and 2,564 women) who were ≥60 years old. SUA and ALT measurements (levels 1-3) and clinical parameters were recorded. Metabolic syndrome was diagnosed according to the criteria of the National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III). The association between the combined SUA and ALT l...
Source: Medical Science Monitor - January 21, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Effect of Switching from a Progestin-Primed Ovarian Stimulation Protocol to a Modified Ultra-Long Protocol Among Women Who Had 1 Progestin-Primed Ovarian Stimulation (PPOS) Failure Verses Those Who Had 2 PPOS Failures.
Authors: Shen X, Gao H, Chen Q, Cai R, Lyu Q, Wang Y, Wang L, Kuang Y Abstract BACKGROUND There is little research on whether normoresponsive patients who produced poor-quality embryos once verses those who produced poor-quality embryos twice when using a single COH protocol should change to a different controlled ovarian hyperstimulation (COH) protocol. MATERIAL AND METHODS In this retrospective study, we enrolled 108 patients with 1 PPOS failure who chose to continue receiving the progestin-primed ovarian stimulation (PPOS) protocol (n=61) versus those who decided to switch to the modified ultra-long protocol (n=...
Source: Medical Science Monitor - January 20, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Romidepsin (FK228) in a Mouse Model of Lipopolysaccharide-Induced Acute Kidney Injury is Associated with Down-Regulation of the CYP2E1 Gene.
CONCLUSIONS In a mouse model of LPS-induced AKI, treatment with romidepsin (FK228) downregulated the expression of CYP2E1 by inhibiting the binding if HNF-1a with the CYP2E1 promoter to reduce renal injury. PMID: 31954012 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - January 20, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Electrocardiogram-Based R Wave Pulse Wave Index for Assessment of Carotid Atherosclerosis.
In this study, we investigated the benefits of the electrocardiogram (ECG)-based R wave pulse wave index (ERWVI) for the diagnosis of CA. MATERIAL AND METHODS According to CA examinations by color Doppler ultrasound, patients were assigned to positive and negative groups. The ECG R wave-Pulse wave transit time (ERWPTT) was obtained by synchronously collecting ECG signals (R wave in ECG) and the time variations in maximum finger pulse oxygen (DOP) on the ECG monitor. RESULTS ERPWI was positively correlated with sex, age, BMI, diastolic/systolic blood pressure, fasting blood glucose, uric acid, cholesterol and triglyceride l...
Source: Medical Science Monitor - January 18, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Risk Factors for Asymptomatic Intracranial Small Aneurysm Rupture Determined by Electrocardiographic-Gated 4D Computed Tomographic (CT) Angiography.
Authors: Gu Y, Zhang Y, Luo M, Zhang H, Liu X, Miao C Abstract BACKGROUND To study the risk predictors of intracranial asymptomatic small aneurysm rupture by electrocardiographic (ECG)-gated 4D-CT angiography (4D-CTA). MATERIAL AND METHODS A total of 168 patients with intracranial aneurysms
Source: Medical Science Monitor - January 18, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Anti-Inflammatory and Antioxidant Effects of Acetyl-L-Carnitine on Atherosclerotic Rats.
CONCLUSIONS ALCAR can inhibit the expressions of inflammatory factors and antioxidation to suppress the development of atherosclerosis by adjusting blood lipid in the myocardium of AS rats. PMID: 31945029 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - January 18, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Prognostic Value of Pre-Infarction Angina Combined with Mean Platelet Volume to Lymphocyte Count Ratio for No-Reflow and Short-Term Mortality in Patients with ST-Segment Elevation Myocardial Infarction Undergoing Percutaneous Coronary Intervention.
Authors: Chen X, Meng Y, Shao M, Zhang T, Han L, Zhang W, Zhang H, Hai H, Li G Abstract BACKGROUND The aim of the present study was to investigate the clinical predictive value of pre-infarction angina (PIA) combined with mean platelet volume to lymphocyte count ratio (MPVLR) for no-reflow phenomenon and short-term mortality in patients with ST-segment elevation myocardial infarction (STEMI) undergoing percutaneous coronary intervention (PCI). MATERIAL AND METHODS A total of 1009 STEMI patients who had undergone PCI were enrolled and subdivided into 4 groups based on the occurrence of PIA and the presence of MPVLR ...
Source: Medical Science Monitor - January 18, 2020 Category: Research Tags: Med Sci Monit Source Type: research