Psychological Impact and Coping Strategies of Frontline Medical Staff in Hunan Between January and March 2020 During the Outbreak of Coronavirus Disease 2019 (COVID ‑19) in Hubei, China.
CONCLUSIONS The COVID‑19 outbreak in Hubei resulted in increased stress for medical staff in adjacent Hunan province. Continued acknowledgment of the medical staff by hospital management and the government, provision of infection control guidelines, specialized equipment and facilities for the management of COVID‑19 infection should be recognized as factors that may encourage medical staff to work during future epidemics. PMID: 32291383 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - April 17, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Evaluation of Risk Factors for Falls in Patients with Rheumatoid Arthritis.
Authors: Mikos M, Kucharska E, Lulek AM, Kłosiński M, Batko B Abstract BACKGROUND The aim of our study was to investigate the risk factors for falls in the rheumatoid arthritis (RA) patient population in Poland. This would be a major step towards the development of new fall prevention programs. MATERIAL AND METHODS There were 450 RA patients who met the criteria of the American College of Rheumatology who participated in this study. The average age of patient participants was 54.2 years; the average RA duration was 15.1 years. All patients filled out the study questionnaire regarding falls, medications, and disea...
Source: Medical Science Monitor - April 17, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Comparison of the Indicators of Psychological Stress in the Population of Hubei Province and Non-Endemic Provinces in China During Two Weeks During the Coronavirus Disease 2019 (COVID-19) Outbreak in February 2020.
CONCLUSIONS During a two-week period, front-line health workers and people in Hubei Province became less anxious about the COVID-19 epidemic, but sleep quality did not improve. Despite public awareness, levels of anxiety exist that affect the quality of life during epidemics, including periods of population quarantine. Therefore, health education should be combined with psychological counseling for vulnerable individuals. PMID: 32294078 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - April 17, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Multiple Bioinformatics Analyses of Integrated Gene Expression Profiling Data and Verification of Hub Genes Associated with Diabetic Retinopathy.
CONCLUSIONS Multiple bioinformatics analyses verified that FH could be used as a potential diagnostic marker and new therapeutic target of DR. PMID: 32294661 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - April 17, 2020 Category: Research Tags: Med Sci Monit Source Type: research

The Effects of Hesperidin on Neuronal Apoptosis and Cognitive Impairment in the Sevoflurane Anesthetized Rat are Mediated Through the PI3/Akt/PTEN and Nuclear Factor- κB (NF-κB) Signaling Pathways.
This study aimed to investigate the effects of HPD on cerebral morphology and cognitive behavior in sevoflurane anesthetized neonatal rats and the molecular mechanisms involved. MATERIAL AND METHODS Sixty neonatal Sprague-Dawley rats were divided into five groups, including the untreated control group, and the sevoflurane anesthesia groups untreated and treated with 25 mg/kg/day of HPD (HPD25), 50 mg/kg/day of HPD (HPD50), and 100 mg/kg/day of HPD (HPD100). The rat model was created by the administration of sevoflurane on the sixth postnatal day (P6) and for a further three days. Neonatal rats pre-treated with HPD for 19 d...
Source: Medical Science Monitor - April 17, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Comparison of Multiple Quantitative Evaluation Indices of Theoretical Knowledge and Clinical Practice Skills and Training of Medical Interns in Cardiovascular Imaging Using Blended Teaching and the Case Resource Network Platform (CRNP).
CONCLUSIONS Levels of theoretical knowledge and clinical practice skills during medical intern training in cardiovascular imaging based on BT using the CRNP teaching technology improved theoretical knowledge and practical skills. PMID: 32297597 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - April 17, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Progress and Perspectives in Point of Care Testing for Urogenital Chlamydia trachomatis Infection: A Review.
Authors: Peng L, Chen JL, Wang D Abstract Worldwide, genital infection with Chlamydia trachomatis (C. trachomatis) is one of the most common sexually transmitted infections. Most infections are asymptomatic. However, particularly in women, untreated infection with C. trachomatis can lead to complications that include pelvic inflammatory disease, infertility, and tubal ectopic pregnancy. Rapid methods for early and accurate diagnosis for infection with C. trachomatis that can be performed in the clinic would allow for earlier treatment to prevent complications. Traditional laboratory-based tests for C. trachomatis i...
Source: Medical Science Monitor - April 17, 2020 Category: Research Tags: Med Sci Monit Source Type: research

CYP2A13 Acts as the Main Metabolic CYP450s Enzyme for Activating Leonurine in Human Bronchial Epithelial Cells.
CONCLUSIONS Leonurine can be effectively activated through CYP2A13 enzyme metabolism, and further inhibits activity of human lung epithelial cells (BEAS-2B). Therefore, CYP2A13 is a main metabolic enzyme for leonurine in BEAS-2B cells. PMID: 32284524 [PubMed - indexed for MEDLINE] (Source: Medical Science Monitor)
Source: Medical Science Monitor - April 16, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Development and Validation of a Medication Selection Model Under Clinical Application of Renin-Angiotensin Inhibitor Combined with Calcium Channel Blocker for Hypertension Patients.
CONCLUSIONS The outcome of our study suggests that independent discriminating factors that influence the clinical selection of different RAS inhibitors were elderly patient, renal insufficiency, and hyperlipidemia; and the RAISM constructed in this study has good predictability and clinical benefit. PMID: 32285846 [PubMed - indexed for MEDLINE] (Source: Medical Science Monitor)
Source: Medical Science Monitor - April 16, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Expression and Function of Toll-Like Receptor 10 (TLR10) in Diffuse Large B Cell Lymphoma, Acute Myeloid Leukemia, and Glioma.
CONCLUSIONS Taken together, these results suggest that TLR10 could serve as a promising theranostic target for patients with glioma and is a potential biomarker for distinguishing PCNSL from GBM. PMID: 32287174 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - April 16, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Levetiracetam Reduces Early Inflammatory Response After Experimental Intracerebral Hemorrhage by Regulating the Janus Kinase 2 (JAK2)-Signal Transducer and Activator of Transcription 3 (STAT3) Signaling Pathway.
Authors: Xiong J, Zhou H, Lu D, Wang Z, Liu H, Sun Y, Xu J, Feng Y, Xing A Abstract BACKGROUND Levetiracetam (LEV) is an antiepileptic drug that promotes recovery of neurological function by alleviating inflammatory reactions. However, it is not known whether it can improve secondary brain injury after intracerebral hemorrhage (ICH). The aim of this study was to determine whether LEV can reduce early inflammatory response after ICH in rats. MATERIAL AND METHODS An in vitro model of early inflammation was created by treating microglia cells with lipopolysaccharide (LPS). After exposure to various concentrations of L...
Source: Medical Science Monitor - April 16, 2020 Category: Research Tags: Med Sci Monit Source Type: research

The Necessity of Clinical Rh Phenotypic Serological Detection and Homotypic Infusion in Patients with Repeated Blood Transfusion.
CONCLUSIONS The consistency of the transfusion with ABO and 5 significant Rh serological antigens could prevent and decrease the high frequency production of isoantibodies, which is of vital importance in reducing the incidence rate of adverse effects in patients receiving transfusions. PMID: 32279065 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - April 14, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Active Surveillance of Prostate Cancer Using Multiparametric Magnetic Resonance Imaging: A Review of the Current Role and Future Perspectives.
Authors: Sklinda K, Mruk B, Walecki J Abstract Clinically, active surveillance involves continuous monitoring of patients who may be at risk for disease. Patients with low-grade and early-stage prostate cancer may benefit from active surveillance, rather than undergoing surgical and medical treatments that are associated with side effects. In these cases, the role of active surveillance is to ensure that there is no progression of the disease. However, active surveillance may be associated with a risk of under-diagnosis. Previously, the assignment of risk categories and patient monitoring were based on digital rect...
Source: Medical Science Monitor - April 14, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Wnt-C59 Attenuates Pressure Overload-Induced Cardiac Hypertrophy via Interruption of Wnt Pathway.
CONCLUSIONS Collectively, Porcupine inhibitor Wnt-C59 attenuates pressure overload-induced cardiac hypertrophic via interruption of the Wnt/ß-catenin signaling pathway, and it might be a promising drug for patients with cardiac hypertrophy. PMID: 32279067 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - April 14, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Bioinformatics Analysis for Multiple Gene Expression Profiles in Sepsis.
CONCLUSIONS Our findings identified several key genes and pathways related to sepsis development. PMID: 32280132 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - April 14, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Ear Crease Features Are Associated with Complexity of Coronary Lesions.
Authors: Liu Z, Qiu C, Xu J, Zhang Y, Cui Q, Guan G, Pan S Abstract BACKGROUND The presence of a Frank's sign ear crease is closely correlated with coronary artery disease (CAD). The SYNTAX score indicates the complexity of coronary lesions. This present investigation sought to identify the correlation between SYNTAX score and several specific ear creases. MATERIAL AND METHODS Four specific types of ear creases - crossing crease not originated from ear hole (CC-NEH), crossing crease originated from ear hole (CC-EH), vertical creases on the face side (VC-F), and vertical creases dividing earlobe and face (VC-EF) - w...
Source: Medical Science Monitor - April 14, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Public Health Interventions to Mitigate Early Spread of SARS-CoV-2 in Poland.
This study aimed (1) to present public health interventions to mitigate the early spread of SARS-CoV-2 implemented in Poland between January 9 and March 29, 2020, and (2) to analyze the potential impact of these regulations on the early phase of the COVID-19 outbreak in Poland. All legal regulations published in the Journal of Laws between January 9 and March 29, 2020, were analyzed. Out of 406 legal regulations identified, 56 were related to the COVID-19 outbreak. Moreover, the official announcements published on the governmental websites dedicated to the coronavirus and health issues were analyzed. On March 4, Poland rep...
Source: Medical Science Monitor - April 14, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Fibroblast Growth Factor (FGF) Signaling Protects Against Acute Pancreatitis-Induced Damage by Modulating Inflammatory Responses.
CONCLUSIONS FGF signaling protects against AP-mediated damage by inhibition of AP-activating inflammatory responses. PMID: 32283546 [PubMed - as supplied by publisher] (Source: Medical Science Monitor)
Source: Medical Science Monitor - April 14, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Erratum: Upregulation of miR-9 Target CBX7 Regulates Invasion Ability of Bladder Transitional Cell Carcinoma.
Authors: Xie D, Shang C, Zhang H, Guo Y, Tong X Abstract The authors informed the journal that an error occurred in their manuscript. The authors selected the wrong figure when uploading it due to the similarity of figures. They found this error when they were periodically sorting the experimental data and contacted the journal. This change does not affect the final results and conclusion. Reference: 1. Dalong Xie, Chao Shang, Hui Zhang, Yan Guo, Xiaojie Tong: Upregulation of miR-9 Target CBX7 Regulates Invasion Ability of Bladder Transitional Cell Carcinoma. Med Sci Monit 2015; 21: 225-230. DOI: 10.12659/MSM.89323...
Source: Medical Science Monitor - April 13, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Bioinformatics Analysis of the Expression of Key Long Intergenic Non-Protein Coding RNA Genes in Bladder Cancer.
CONCLUSIONS LncRNA, including LINC00460 and ADAMTS9-AS1, might play a crucial role in the biosynthesis network of bladder cancer. Differential expression results of ADAMTS9-AS1 suggests it may be correlated with a worse prognosis and a shorter survival time. We outlined the biosynthesis network that regulates lncRNAs in bladder cancer. Further experimental data is needed to validate our results. PMID: 32277695 [PubMed - as supplied by publisher] (Source: Medical Science Monitor)
Source: Medical Science Monitor - April 13, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Lung Cancer Inhibition by Betulinic Acid Nanoparticles via Adenosine 5'-Triphosphate (ATP)-Binding Cassette Transporter G1 Gene Downregulation.
Authors: Zhao H, Mu X, Zhang X, You Q Abstract BACKGROUND Despite scientific advancement in radiotherapy and chemotherapy, the 5-year survival rate of lung cancer patients is around 15%. The present study explored the anticancer potential of betulinic acid nanoparticles against lung cancer cells. MATERIAL AND METHODS The proliferative changes in lung cancer cells by betulinic acid nanoparticles were measured by MTT assay. Cell cycle analysis was performed by flow cytometry using propidium iodide stain. Transwell and wound healing assay were used for determination of HKULC2 cell metastatic potential. RESULTS The bet...
Source: Medical Science Monitor - April 13, 2020 Category: Research Tags: Med Sci Monit Source Type: research

A Review of the Molecular Pathways Involved in Resistance to BRAF Inhibitors in Patients with Advanced-Stage Melanoma.
Authors: Tian Y, Guo W Abstract Melanoma is an aggressive malignancy of melanocytes and most commonly arises in the skin. In 2002, BRAF gene mutations were identified in melanoma, and this finding resulted in the development of several small-molecule molecular inhibitors that specifically targeted the BRAF V600E mutation. The development of targeted therapies for advanced-stage melanoma, including tyrosine kinase inhibitors (TKIs) of the BRAF (V600E) kinase, vemurafenib and dabrafenib, have been approved for the treatment of advanced melanoma leading to improved clinical outcomes. However, the development of BRAF i...
Source: Medical Science Monitor - April 11, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Erratum: Association of 3 Common Polymorphisms of IL-27 Gene with Susceptibility to Cancer in Chinese People: Evidence from an Updated Meta-Analysis of 27 Studies.
Authors: Zhang M, Tan X, Huang J, Ke Z, Ge Y, Xiong H, Lu W, Fang L, Cai Z, Wu S Abstract The authors informed the journal that an error occurred in their manuscript.Figure 3C was mistakenly merged by the authors.The new version of the Figure 3C is as below.Reference:1. Meng Zhang, Xiuxiu Tan, Junjie Huang, Zekai Ke, Yukun Ge, Hu Xiong, Wei Lu, Lu Fang, Zhiming Cai, Song Wu: Association of 3 Common Polymorphisms of IL-27 Gene with Susceptibility to Cancer in Chinese: Evidence From an Updated Meta-Analysis of 27 Studies. Med Sci Monit 2015; 21: 2505-2513. DOI: 10.12659/MSM.895032. PMID: 32275054 [PubMed - in pro...
Source: Medical Science Monitor - April 11, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Inhibitor of Differentiation 1 (ID1) Facilitates the Efficacy of Sorafenib in Non-Small Cell Lung Cancer Cells through Suppressing Epithelial to Mesenchymal Transition.
CONCLUSIONS The expression of ID1 is dose-dependently inhibited by sorafenib, and the overexpression of ID1 contributes to the antitumor activity of sorafenib by suppressing EMT development. Our results indicate that ID1 might be a potential target for the antitumor activity of sorafenib in NSCLC and that targeting ID1 is a feasible strategy to improve the sensitivity of NSCLC cells to sorafenib. PMID: 32275644 [PubMed - as supplied by publisher] (Source: Medical Science Monitor)
Source: Medical Science Monitor - April 11, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Effects of an Informational Video About Anesthesia on Pre- and Post-Elective Cesarean Section Anxiety and Recovery: A Randomized Controlled Trial.
This study was a single-center prospective randomized trial. We randomly divided 121 pregnant women who were scheduled to undergo elective cesarean section (CS) into 2 groups: one group was shown an informational video (video group) and another group was not (control group). Spielberger's state-trait anxiety inventory was used to evaluate the perioperative anxiety level of parturient women at 3 time points: 1 day before CS, after video education, and 2 days after CS. Salivary cortisol level was evaluated to assess the patients' anxiety level at these 3 time points. Finally, the maternal satisfaction scale for CS and an obs...
Source: Medical Science Monitor - April 10, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Bromodomains and Extra-Terminal (BET) Inhibitor JQ1 Suppresses Proliferation of Acute Lymphocytic Leukemia by Inhibiting c-Myc-Mediated Glycolysis.
CONCLUSIONS The BET inhibitor JQ1 suppresses the proliferation of ALL by inhibiting c-Myc-mediated glycolysis, thus providing a new strategy for the treatment of ALL. PMID: 32266878 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - April 10, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Long Non-Coding RNA MACC1-AS1 Is Involved in Distant Recurrence of Hepatocellular Carcinoma After Surgical Resection.
CONCLUSIONS MACC1-AS1 is involved in the distant recurrence of HCC, and its actions are possibly mediated by TGF-ß1. PMID: 32267834 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - April 10, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Upregulation of Neural Cell Adhesion Molecule 1 (NCAM1) by hsa-miR-141-3p Suppresses Ameloblastoma Cell Migration.
CONCLUSIONS In this study, highly expressed NCAM1 was found in AB, and it suppressed the migration of AB cells and was regulated by miR-141-3p, suggesting its potential value as a therapeutic target for AB. PMID: 32269209 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - April 10, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Construction and Validation of Nomograms for Predicting the Prognosis of Uterine Leiomyosarcoma: A Population-Based Study.
CONCLUSIONS The developed nomograms are useful tools for precisely analyzing the prognosis of uLMS patients, which could help clinicians in making personalized survival predictions and assessing individualized clinical options. PMID: 32270788 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - April 10, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Retracted: Minimally Invasive Unilateral vs. Bilateral Pedicle Screw Fixation and Lumbar Interbody Fusion in Treatment of Multi-Segment Lumbar Degenerative Disorders.
Authors: Liu X, Li G, Wang J, Zhang H Abstract We have retracted this publication because we were informed that an image used by the authors was copied from the following article: J Korean Neurosurg Soc. 2011 Nov; 50(5): 441-445. Minimally Invasive Multi-Level Posterior Lumbar Interbody Fusion Using a Percutaneously Inserted Spinal Fixation System: Technical Tips, Surgical Outcomes (https: //www.ncbi.nlm.nih.gov/pmc/articles/PMC3259464/pdf/jkns-50-441.pdf) (https: //www.ncbi.nlm.nih.gov/pmc/articles/PMC3259464/). Reference: 1. Xiaoyang Liu, Guangrun Li, Jiefeng Wang, Heqing Zhang: Minimally Invasive Unilateral vs. ...
Source: Medical Science Monitor - April 10, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Ginsenoside Rg1 Performs Anti-Aging Functions by Suppressing Mitochondrial Pathway-Mediated Apoptosis and Activating Sirtuin 3 (SIRT3)/Superoxide Dismutase 2 (SOD2) Pathway in Sca-1 ⁺ HSC/HPC Cells of an Aging Rat Model.
Ginsenoside Rg1 Performs Anti-Aging Functions by Suppressing Mitochondrial Pathway-Mediated Apoptosis and Activating Sirtuin 3 (SIRT3)/Superoxide Dismutase 2 (SOD2) Pathway in Sca-1⁺ HSC/HPC Cells of an Aging Rat Model. Med Sci Monit. 2020 Apr 07;26:e920666 Authors: Zhou Y, Wang YP, He YH, Ding JC Abstract BACKGROUND Aging is characterized by progressive deterioration in metabolic and physiological process. The present research assessed the antagonistic effects and mechanisms of Ginsenoside Rg1 (Rg1) on aging of HSCs/HPCs. MATERIAL AND METHODS Fifty male Sprague-Dawley (SD) rats were treated and divi...
Source: Medical Science Monitor - April 9, 2020 Category: Research Tags: Med Sci Monit Source Type: research

High Expression of RING Finger Protein 126 Predicts Unfavorable Prognosis of Epithelial Ovarian Cancer.
CONCLUSIONS Upregulated protein level of RNF126 in EOC tissues is a biomarker predicting poor outcomes of EOC patients. PMID: 32254065 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - April 9, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Sex Differences in Osteoarthritis Pathogenesis: A Comprehensive Study Based on Bioinformatics.
CONCLUSIONS The DEGs identified may be involved in different OA disease progression mechanisms between males and females, and they are considered as treatment targets or prognosis markers for males and females. The pathogenesis mechanism is sex-dependent. PMID: 32255771 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - April 9, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Multi-Omics Analysis Reveals the Pan-Cancer Landscape of Bone Morphogenetic Proteins.
CONCLUSIONS Our results define the landscape of the BMP family at a systems level and open potential therapeutic opportunities for cancer patients. PMID: 32248202 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - April 7, 2020 Category: Research Tags: Med Sci Monit Source Type: research

The Effects of Low-Dose and High-Dose Decoctions of Fructus aurantii in a Rat Model of Functional Dyspepsia.
CONCLUSIONS In the rat model of FD, low-dose Fructus aurantii with stir-fried wheat bran increased gastrointestinal motility and gastrointestinal hormone levels. PMID: 32248203 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - April 7, 2020 Category: Research Tags: Med Sci Monit Source Type: research

ZW10 Binding Factor (ZWINT), a Direct Target of Mir-204, Predicts Poor Survival and Promotes Proliferation in Breast Cancer.
CONCLUSIONS Overall, our results indicated that miR-204/ZWINT/cell cycle process might play an important role in breast cancer progression. PMID: 32248204 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - April 7, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Bifidobacterium infantis Relieves Allergic Asthma in Mice by Regulating Th1/Th2.
CONCLUSIONS B. infantis can reduce the infiltration of inflammatory cells induced by OVA-specific antibodies in mice. B. infantis has therapeutic effects on allergic asthma by promoting Th1 and inhibiting Th2 immune responses. PMID: 32249275 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - April 7, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Osteoarthritis is Prevented in Rats by Verbascoside via Nuclear Factor kappa B (NF- κB) Pathway Downregulation.
CONCLUSIONS Thus, verbascoside inhibited inflammatory cytokine secretion in the OA rats by targeting P2X7R expression, production of matrix metalloproteinase, PGE2 and downregulation of NF-kappaB signaling pathway. Therefore, verbascoside may be used as potent agent for osteoarthritis treatment. PMID: 32249762 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - April 7, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Identification of Genes with Prognostic Value in the Breast Cancer Microenvironment Using Bioinformatics Analysis.
CONCLUSIONS Our bioinformatics analysis identified 31 tumor microenvironment-related genes as potential prognostic predictors for breast cancer patients. Some of these genes that have not been widely investigated previously, such as CXCL9, GPR18, S1PR4, SASH3, and PYH1N1, might be additional predictive factors for BC patients. PMID: 32251269 [PubMed - as supplied by publisher] (Source: Medical Science Monitor)
Source: Medical Science Monitor - April 7, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Ganoderma Lucidum Polysaccharides Ameliorates Hepatic Steatosis and Oxidative Stress in db/db Mice via Targeting Nuclear Factor E2 (Erythroid-Derived 2)-Related Factor-2/Heme Oxygenase-1 (HO-1) Pathway.
CONCLUSIONS These results indicate that GDLP against T2DM-induced hepatic steatosis, oxidative stress, and inflammation by improving the Nrf2/HO-1 signaling pathway in db/db mice, suggesting the GDLP may serve as an effective strategy for in fatty liver treatment. PMID: 32245940 [PubMed - as supplied by publisher] (Source: Medical Science Monitor)
Source: Medical Science Monitor - April 6, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Anticancer Effect of Radix Astragali on Cholangiocarcinoma In Vitro and Its Mechanism via Network Pharmacology.
CONCLUSIONS RA is an active medicinal material that can be developed into a safe and effective multi-targeted anticancer treatment for CCA. PMID: 32246704 [PubMed - as supplied by publisher] (Source: Medical Science Monitor)
Source: Medical Science Monitor - April 6, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Pulmonary High-Resolution Computed Tomography (HRCT) Findings of Patients with Early-Stage Coronavirus Disease 2019 (COVID-19) in Hangzhou, China.
CONCLUSIONS The imaging manifestations of early-stage COVID-19 are relatively mild, and the imaging findings of some patients are not typical, which can easily lead to missed diagnoses. Thus, suspected cases need to be closely monitored, and epidemiological history and clinical laboratory examination should also be considered during diagnosis. PMID: 32246819 [PubMed - as supplied by publisher] (Source: Medical Science Monitor)
Source: Medical Science Monitor - April 6, 2020 Category: Research Tags: Med Sci Monit Source Type: research

A Retrospective Population Study to Develop a Predictive Model of Prediabetes and Incident Type 2 Diabetes Mellitus from a Hospital Database in Japan Between 2004 and 2015.
CONCLUSIONS A prognostic model based on six variables was predictive for incident type 2 diabetes mellitus and prediabetes in a healthy population in Japan. PMID: 32235819 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - April 4, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Magnetic Resonance Imaging versus Computed Tomography for Biliary Tract Intraductal Papillary Mucinous Neoplasm (BT-IPMN): A Diagnostic Performance Analysis.
CONCLUSIONS MRI appears to be a more accurate and reliable method than CT for depicting BT-IPMN. PMID: 32235820 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - April 4, 2020 Category: Research Tags: Med Sci Monit Source Type: research

An Integrated Microarray Analysis Reveals Significant Diagnostic and Prognostic Biomarkers in Pancreatic Cancer.
CONCLUSIONS These 7 DEGs might be potential diagnostic and prognostic biomarkers for PAC and help uncovering the mechanism of PAC. PMID: 32235821 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - April 4, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Connection between SOX7 Expression and  Breast Cancer Prognosis.
Connection between SOX7 Expression and Breast Cancer Prognosis. Med Sci Monit. 2020 Apr 02;26:e921510 Authors: Qin CX, Yang XQ, Zhan ZY Abstract BACKGROUND SOX7 exerts a repressing effect against tumors and imposes vital influences on malignancies. Our research discussed the importance of SOX7 in breast cancer prognoses. MATERIAL AND METHODS SOX7 mRNA expression in breast cancer tissues samples and matched adjacent normal controls of breast cancer patients was measured by quantitative real-time-polymerase chain reaction (qRT-PCR). The relationship of SOX7 with clinicopathological characteristics w...
Source: Medical Science Monitor - April 4, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Identification of Potential Therapeutic Targets and Pathways of Liraglutide Against Type 2 Diabetes Mellitus (T2DM) Based on Long Non-Coding RNA (lncRNA) Sequencing.
CONCLUSIONS In this study, we screened 104 lncRNA therapeutic targets and several signaling pathways (Wnt, PPAR, amino acid metabolism signaling pathway, mTOR, and lipid metabolism-related pathways) of liraglutide against T2DM based on lncRNA sequencing. PMID: 32238798 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - April 4, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Effects of Dapagliflozin and Sitagliptin on Insulin Resistant and Body Fat Distribution in Newly Diagnosed Type 2 Diabetic Patients.
This study was an open-label, parallel controlled study. Patients were included if they were newly diagnosed with type 2 diabetes (
Source: Medical Science Monitor - April 4, 2020 Category: Research Tags: Med Sci Monit Source Type: research

A Network Pharmacology Study on the Mechanisms of the Herbal Extract, Christina Loosestrife, for the Treatment of Nephrolithiasis.
CONCLUSIONS Network pharmacology analysis of the herbal extract, Christina Loosestrife, identified multiple active compounds, targets, and pathways involved in the effects on nephrolithiasis. PMID: 32241963 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - April 4, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Long Non-Coding RNA (lncRNA) SNHG5 Participates in Vertical Sleeve Gastrectomy for Type II Diabetes Mellitus by Regulating TGR5.
CONCLUSIONS By downregulating expression of the SNHG5 gene and then altering expression of the TGR5 gene, the damage to colorectal cells induced by high glucose was alleviated. This may be one of the mechanisms underlying the effect of sleeve gastric surgery in treatment of diabetes mellitus. PMID: 32242546 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - April 4, 2020 Category: Research Tags: Med Sci Monit Source Type: research