Mechanism of Cxc Chemokine Ligand 5 (CXCL5)/Cxc Chemokine Receptor 2 (CXCR2) Bio-Axis in Mice with Acute Respiratory Distress Syndrome.
CONCLUSIONS We found that CXCL5/CXCR2 accelerated the progression of ARDS, partly by upregulation of MMP2 and MMP9 in lung tissues with the release of inflammatory factors. PMID: 31311916 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - July 18, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Culprit Lesion Characteristics in Young Patients with Hyperhomocysteinemia.
In this study we investigated the relationship between culprit atherosclerotic plaque phenotype assessed by optical coherence tomography (OCT) and hyperhomocysteinemia (HHcy) in young patients. MATERIAL AND METHODS We investigated the OCT imaging and HHcy of 123 lesions in 123 young patients (≤45 years of age). According to OCT images, culprit lesions were classified as thin-cap fiber atheroma (TCFA), thrombus, and other. The 123 patients were grouped as: HHcy group (53 cases, HHcy ≥15.5 µmol/l) and control group (70 cases, HHcy
Source: Medical Science Monitor - July 18, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Sesamin Promotes Osteoblastic Differentiation and Protects Rats from Osteoporosis.
Authors: Ma ZP, Zhang ZF, Yang YF, Yang Y Abstract BACKGROUND Osteoporosis is a common osteopathy, resulting in fractures, especially in elder people. Sesamin has many pharmacological effects, including supplying calcium. However, how sesamin might prevent osteoporosis is still under study. MATERIAL AND METHODS Bone marrow stromal cells (BMSCs) extracted from rat femur were induced for osteoblastic differentiation. Cell proliferation, alkaline phosphatase (ALP), osterix (OSX), SRY-box 9 (SOX9), runt-related transcription factor 2 (RUNX2), osteocalcin (OCN), ß-catenin, low density lipoprotein receptor-related ...
Source: Medical Science Monitor - July 18, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Burnout Syndrome, Mental Splitting and Depression in Female Health Care Professionals.
This study intends examination of relationships between burnout syndrome, depression, and Kernberg's concept of splitting. MATERIAL AND METHODS In this present study, we assessed 132 female health care professionals working with a population of diabetic patients utilizing Burnout Measure (BM) Splitting Index (SI), Beck Depression Inventory II (BDI-II), and additional psychometric instruments, the Toronto Alexithymia Scale and the Trauma Symptoms Checklist. RESULTS The study results indicated significant Spearman correlations between burnout syndrome as measured by BM and depression (BDI-II) (R=0.62, P
Source: Medical Science Monitor - July 17, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Low-Frequency Fluctuations Amplitude Signals Exhibit Abnormalities of Intrinsic Brain Activities and Reflect Cognitive Impairment in Leukoaraiosis Patients.
CONCLUSIONS This research showed that LA patients exhibited abnormal intrinsic-brain activities. Furthermore, altered ALFF was positively correlated with executive function scores. PMID: 31302662 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - July 17, 2019 Category: Research Tags: Med Sci Monit Source Type: research

A Low Lean-to-Fat Ratio Reduces the Risk of Acute Exacerbation of Chronic Obstructive Pulmonary Disease in Patients with a Normal or Low Body Mass Index.
This study aimed to examine the association between acute exacerbations of COPD and the lean-to-fat (LTF) ratio in patients with a normal or low BMI. MATERIAL AND METHODS Patients with COPD (n=68) underwent assessment of body composition, in whom 43 cases had a normal BMI (18.5 to 25 kg/m²) and 14 cases were underweight (
Source: Medical Science Monitor - July 17, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Association Between Body Mass Index (BMI) and Brachial-Ankle Pulse Wave Velocity (baPWV) in Males with Hypertension: A Community-Based Cross-Section Study in North China.
Authors: Huang J, Chen Z, Yuan J, Zhang C, Chen H, Wu W, Chen Z, Liu Y, Zheng M, Chen S, Wu S, Chen Y Abstract BACKGROUND The aim of this study was to investigate the association between body mass index (BMI) and brachial-ankle pulse wave velocity (baPWV) in hypertensive males. MATERIAL AND METHODS Altogether, 14 866 male hypertensive participants were included in the analysis. Participants were divided into 3 groups: low BMI group (BMI
Source: Medical Science Monitor - July 17, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Imaging Analysis of Ganglioneuroma and Quantitative Analysis of Paraspinal Ganglioneuroma.
CONCLUSIONS A hypodense mass was observed for GN on plain scan and presented delayed enhancement on contrast enhancement. VER or AER/VER combination is more accurate than AER for the diagnosis of paravertebral GN. PMID: 31306406 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - July 17, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Can Inspiratory Muscle Training Improve Exercise Tolerance and Lower Limb Function After Myocardial Infarction?
CONCLUSIONS Use of IMT in the ambulatory rehabilitation program of MI patients resulted in improved rehabilitation efficacy, leading to a significant improvement in physical condition. PMID: 31296834 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - July 14, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Two GEO MicroRNA Expression Profile Based High-Throughput Screen to Identify MicroRNA-31-3p Regulating Growth of Medullary Thyroid Carcinoma Cell by Targeting RASA2.
Authors: Jiang M, Shi X, Zhu H, Wei W, Li J Abstract BACKGROUND Medullary thyroid carcinoma (MTC), a rare type of thyroid cancer, is a big challenge in clinical treatment. However, the pathogenesis of MTC remains poorly understand. MicroRNAs (miRNAs) were previously demonstrated to be involved in the pathogenesis of MTC, however, the roles of majority of miRNAs in MTC are still undetermined. MATERIAL AND METHODS Two GEO miRNA expression profiles (GSE40807, GSE97070) were downloaded, and the differentially expressed miRNAs (DEmiRNAs) of GSE40807 and GSE97070 were analyzed by bioinformatics methods. Expressions of mi...
Source: Medical Science Monitor - July 14, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Inhibition of MicroRNA-381 Promotes Tumor Cell Growth and Chemoresistance in Clear-Cell Renal Cell Carcinoma.
CONCLUSIONS miR-381 levels were significantly downregulated in renal cancer tissues and miR-381 inhibition promoted tumor cell growth, migration, and chemoresistance. PMID: 31299041 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - July 14, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Factors Influencing Aspirin Hyporesponsiveness in Elderly Chinese Patients.
CONCLUSIONS This study found that baseline Ara, UA level, and ß-blockers use were independently and positively associated with aspirin hyporesponsiveness in elderly Chinese patients, which needs to be validated in large-scale studies. PMID: 31300636 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - July 14, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Anatomical Variations of the Supraorbital and Supratrochlear Nerves: Their Intraorbital Course and Relation to the Supraorbital Margin.
CONCLUSIONS Both the intraorbital and extraorbital course of the branches of the supraorbital and supratrochlear nerves were highly diverse. These variations should be taken into account during medical procedures performed within the orbital and frontal regions. PMID: 31301129 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - July 14, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Diacetyl Hexamethylene Diamine (CAHB) Exerts Pro-Apoptotic and Anti-Proliferative Function in Leukemic T Lymphocytes via Downregulating PI3K/Akt Signaling.
CONCLUSIONS Our data suggest that CAHB might be regarded as a novel treatment agent for T-ALL since it can induce apoptosis and inhibit proliferation of the T-ALL cell line at a relatively low level. PMID: 31301225 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - July 14, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Age-Related Impairment of Structure and Function of Iliac Artery Endothelium in Rats Is Improved by Elevated Fluid Shear Stress.
CONCLUSIONS The present study for the first time shows that EFSS has the ability to improve age-related impairment of endothelial structure and functions. PMID: 31291237 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - July 13, 2019 Category: Research Tags: Med Sci Monit Source Type: research

The Association Between the rs2975760 and rs3792267 Single Nucleotide Polymorphisms of Calpain 10 (CAPN10) and Gestational Diabetes Mellitus.
This study aimed to investigate the association between the rs2975760 and rs3792267 single nucleotide polymorphisms (SNPs) of the calpain 10 (CAPN10) gene and gestational diabetes mellitus. MATERIAL AND METHODS The study included 138 patients with gestational diabetes mellitus and 152 healthy pregnant women. Venous blood was separated, and the DNA was extracted. The rs2975760 and rs3792267SNP polymorphisms of CAPN10 were detected using polymerase chain reaction (PCR). The frequencies of different genotypes in patients with gestational diabetes mellitus and healthy pregnant women were determined, and the relationship betwee...
Source: Medical Science Monitor - July 13, 2019 Category: Research Tags: Med Sci Monit Source Type: research

High Metastasis-Associated Lung Adenocarcinoma Transcript 1 (MALAT1) Expression Promotes Proliferation, Migration, and Invasion of Non-Small Cell Lung Cancer via ERK/Mitogen-Activated Protein Kinase (MAPK) Signaling Pathway.
CONCLUSIONS High MALAT1 expression promotes the proliferation, migration, and invasion of non-small cell lung cancer via the ERK/MAPK signaling pathway. PMID: 31293277 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - July 13, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Long Non-coding RNA Zinc Finger Antisense 1 (ZFAS1) Regulates Proliferation, Migration, Invasion, and Apoptosis by Targeting MiR-7-5p in Colorectal Cancer.
CONCLUSIONS Our study indicated that ZFAS1 directly targeted miR-7-5p, and knockdown of it could inhibit tumor growth, migration, invasion, and induce apoptosis in CRC. These data might provide a potent treatment mechanism or promising biomarker for CRC. PMID: 31295229 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - July 13, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Overexpression of ClC-3 Chloride Channel in Chondrosarcoma: An In Vivo Immunohistochemical Study with Tissue Microarray.
CONCLUSIONS These results demonstrated a high frequency of ClC-3 chloride channel overexpression and subcellular localization differences in MDC and PDC tissue, suggesting a specific role of ClC-3 chloride channel in the pathogenesis of chondrosarcoma. PMID: 31281178 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - July 11, 2019 Category: Research Tags: Med Sci Monit Source Type: research

The Impact of Vitamin D on Cognitive Dysfunction in Mice with Systemic Lupus Erythematosus.
CONCLUSIONS In conclusion, our results indicated that vitamin D played a protective role by suppressing inflammatory cytokines, thereby ultimately inhibiting the progression of apoptosis in a mouse model of SLE. Vitamin D may be promising as a protective intervention in SLE with cognitive dysfunction, and more and more experiments are warranted for its clinical testing in the near future. PMID: 31281179 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - July 11, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Microbial Infections as a Trigger for Acute-on-Chronic Liver Failure: A Review.
Authors: Cai Q, Liu W, Zhu M, Sheng J Abstract ABSTRACT Microbial infection is an important cause of acute-on-chronic liver failure (ACLF), which is a syndrome that results in multiple organ dysfunction or failure and is accompanied by an increased short-term risk of mortality. Early detection and treatment of microbial infection can effectively reduce the mortality of patients with ACLF. However, antimicrobial resistance has recently increased due to the increased use of antimicrobial agents. Therefore, it is important to choose appropriate antibiotics and antifungal agents for early prevention or treatment of pat...
Source: Medical Science Monitor - July 11, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Deficit of Motor Skill Acquisition on the Upper Limb Ipsilesional to the Injured Hemisphere in Individuals with Stroke.
CONCLUSIONS Our findings provide evidence that individuals with stroke might have difficulty in performing visuo-spatial movements and acquiring motor skills with the ipsilateral upper limb. Improvement of ipsilesional limb function increases self-care activity in daily life. Therefore, we recommend that clinicians adopt remedial strategies for ipsilesional limbs. PMID: 31283752 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - July 11, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Intra-Articular Injection of Tranexamic Acid on Perioperative Blood Loss During Unicompartmental Knee Arthroplasty.
This study aimed to compare operative blood loss in patients undergoing UKA treated with an intra-articular injection of TXA with controls undergoing UKA without TXA. MATERIAL AND METHODS The prospective study included 101 patients who underwent UKA between January 2014 to March 2018. All patients completed a preoperative routine examination and were randomized to the study group (n=54) and the control group (n-47). The study group was given an articular injection of TXA (1.5 g in 50 ml normal saline) after the fascia was closed; the control group was injected with the same volume of normal saline. Blood volumes were measu...
Source: Medical Science Monitor - July 11, 2019 Category: Research Tags: Med Sci Monit Source Type: research

LINC00922 Accelerates the Proliferation, Migration and Invasion of Lung Cancer Via the miRNA-204/CXCR4 Axis.
CONCLUSIONS LINC00922 was upregulated in lung cancer, and accelerated lung cancer cells to proliferate, migrate, and invade via targeting the miRNA-204/CXCR4 axis. PMID: 31287095 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - July 11, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Liposomal Curcumin Enhances the Effect of Naproxen in a Rat Model of Migraine.
This study aimed to assess the effect of pretreatment with naproxen and liposomal curcumin compared with naproxen and curcumin solution on oxidative stress parameters and pain in a rat model of migraine. MATERIAL AND METHODS Sixty-three male Wistar rats included a control group (n=9) and a rat model of migraine (n=54) induced by intraperitoneal injection of nitroglycerin (1 mg/0.1 kg). The rat model group was divided into an untreated control group (n=9), a group pretreated with naproxen alone (2.8 mg/kg) (n=9), a group pretreated with naproxen (2.8 mg/kg) combined with curcumin solution (1 mg/0.1 kg) (n=9), a group pretre...
Source: Medical Science Monitor - July 11, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Influence of Deviated Centers of Rotation on Kinematics and Kinetics of a Lumbar Functional Spinal Unit: An In Vitro Study.
CONCLUSIONS The ROM, NZ, and shear force of FSU are sensitive to the vertical COR shift, while the compressive force of FSU is highly sensitive to the horizontal COR shift. Additionally, the kinematics and kinetics of the L2-L3 unit are more sensitive to COR location than those of the L4-L5 unit. PMID: 31280279 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - July 8, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Effects of Exercise-Based Cardiac Rehabilitation in Patients with Acute Coronary Syndrome: A Meta-Analysis.
Authors: Ji H, Fang L, Yuan L, Zhang Q Abstract BACKGROUND Acute coronary syndrome (ACS) has become an important cause of death from cardiovascular disease. Cardiac rehabilitation (CR) plays an essential role in ACS patients after treatment. Therefore, in order to detect the impact of CR on mortality and major adverse cardiac events in patients with ACS, we conducted this meta-analysis. MATERIAL AND METHODS We searched PubMed, Web of science, and EMBASE databases to obtain published research results from 2010 to August 2018 to determine the relevant research. Random-effects model or fixed-effects model were used to...
Source: Medical Science Monitor - July 8, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Association of Intracranial Artery Calcification with Cognitive Impairment in Hemodialysis Patients.
CONCLUSIONS Intracranial artery calcification and low FGF23 could be associated with cognitive impairment in hemodialysis patients. Longitudinal studies are needed to investigate whether intracranial artery calcification and FGF23 could affect cognitive function of hemodialysis patients. PMID: 31280282 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - July 8, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Efficacy of High Specific Volume Polysaccharide - A New Type of Dietary Fiber - On Molecular Mechanism of Intestinal Water Metabolism in Rats With Constipation.
CONCLUSIONS HSVP improved constipation, increased the number of intestinal bacteria, and elevated expression of the VIP-cAMP-PKA-AQP3 signaling pathway. The mechanism of HSVP in regulating intestinal water metabolism in constipated rats may occur through the VIP-cAMP-PKA-AQP3 signaling pathway, and be closely related to changes in intestinal bacteria. The important role of the brain-gut-microbiome axis in the pathogenesis of constipation has been confirmed in this study. PMID: 31280283 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - July 8, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Determination of Risk Factors Related to Supraclavicular Recurrence for Limited-Stage Small Cell Lung Cancer (SCLC) Patients.
CONCLUSIONS Lymphadenopathy at mediastinal level 2 and level 3 prior to chemotherapy were the high-risk factors associated with SCLN recurrence for patients with LS-SCLC. Further work is needed to determine whether patients with these factors can benefit from PSCI. PMID: 31273183 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - July 7, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Burnout Syndrome and Lifestyle Among Primary School Teachers: A Czech Representative Study.
CONCLUSIONS Based on our results, we propose that teachers should be informed about the risk of burnout. We found that some teachers reported they do not know what burnout syndrome is. The primary aim should be to increase awareness. In fact, burnout is a major threat to those who are perfectionists and who tend to work overtime. PMID: 31274132 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - July 7, 2019 Category: Research Tags: Med Sci Monit Source Type: research

RNA Sequencing of Osteosarcoma Gene Expression Profile Revealed that miR-214-3p Facilitates Osteosarcoma Cell Proliferation via Targeting Ubiquinol-Cytochrome c Reductase Core Protein 1 (UQCRC1).
Authors: Zhao X, Wang Q, Lin F, Wang X, Wang Y, Wang J, Wang C Abstract BACKGROUND Osteosarcoma (OS) is a common primary malignant bone tumor for which the molecular mechanisms remain unclear. Studies on coding and non-coding RNAs are needed to determine the molecular mechanism. MATERIAL AND METHODS To explore the potential roles of miRNAs and mRNA in OS, we determined the miRNA and mRNA expression profile of 3 pairs of OS and paracancerous tissues from patients with OS by sequencing and bioinformatics analysis. The expression levels of critical miRNAs and mRNAs were verified in 10 pairs of OS and paracancerous tis...
Source: Medical Science Monitor - July 7, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Differences in Clinical Characteristics and Therapy of Neonatal Acute Respiratory Distress Syndrome (ARDS) and Respiratory Distress Syndrome (RDS): A Retrospective Analysis of 925 Cases.
CONCLUSIONS ARDS mainly occurs in late preterm infants. Its treatment is dependent on iNO and invasive ventilator-assisted therapy, and the surfactant treatment rate was relatively lower in comparison to RDS. RDS accompanied with inflammatory response is also dependent on prolonged use of an invasive ventilator. PMID: 31278248 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - July 7, 2019 Category: Research Tags: Med Sci Monit Source Type: research

A 10-Long Non-Coding RNA-Based Expression Signature as a Potential Biomarker for Prognosis of Acute Myeloid Leukemia.
CONCLUSIONS We developed a 10-lncRNA expression signature to predict the clinical outcome of AML. This approach demonstrates remarkable prognostic and therapeutic potential for AML. PMID: 31278736 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - July 7, 2019 Category: Research Tags: Med Sci Monit Source Type: research

A Novel Use of Model for End-Stage Liver Disease (MELD) Score in Guiding Therapeutic Antibiotics Choice for Critically Ill Cirrhotic Patients.
This study investigated use of the MELD score to guide antibiotics choice. MATERIAL AND METHODS We enrolled 1250 patients with cirrhosis. We collected patient information, including antibiotics administration. Linear regression analyses were performed to determine independent predictors of antibiotic administration. Survival curves were constructed based on Cox regression models. Cox proportional hazard models were used to calculate the hazard ratio, shown by forest plots. RESULTS The population was equally stratified into 4 groups based on the MELD score (Q1: MELD
Source: Medical Science Monitor - July 7, 2019 Category: Research Tags: Med Sci Monit Source Type: research

The Optimal Management for Sub-Centimeter Hepatocellular Carcinoma: Curative Treatments or Follow-Up?
This study aimed to assess whether there was a need to provide curative treatments for sub-centimeter hepatocellular carcinomas (HCCs) to patients at risk for high false positives. MATERIAL AND METHODS We identified patients with primary pathologically diagnosed HCC ≤2 cm from 2004 to 2015 in the Surveillance, Epidemiology and End Results (SEER) database. They were divided according to the interventions they received: local ablation, surgical resection, or liver transplantation. In each group, overall survival and cancer-specific survival were used as endpoints to compare the prognoses between patients with sub-centimet...
Source: Medical Science Monitor - July 6, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Low Expression of Pseudogene POU5F1B Affects Diagnosis and Prognosis in Acute Myeloid Leukemia (AML).
Authors: Yi J, Zhou LY, Yi YY, Zhu X, Su XY, Zhao Q, Lin J, Qian J, Deng ZQ Abstract BACKGROUND The transcription factor Oct-4 is necessary for maintaining pluripotency and self-renewal of embryonic stem cells, and POU5F1B is a processed pseudogene of Oct-4 with coding capacity. The purpose of this study is to evaluate the expression and clinical implication of POU5F1B in AML. MATERIAL AND METHODS The expression of the POU5F1B transcript was evaluated in 175 newly diagnosed AML patients and 39 healthy controls by use of real-time quantitative PCR (RQ-PCR). RESULTS POU5F1B was underexpressed in AML compared with controls (P
Source: Medical Science Monitor - July 6, 2019 Category: Research Tags: Med Sci Monit Source Type: research

A New Insight of Kartogenin Induced the Mesenchymal Stem Cells (MSCs) Selectively Differentiate into Chondrocytes by Activating the Bone Morphogenetic Protein 7 (BMP-7)/Smad5 Pathway.
CONCLUSIONS This study found a new biological intervention method to promote the effect of tendon on bone healing after rotator cuff repair. PMID: 31271564 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - July 6, 2019 Category: Research Tags: Med Sci Monit Source Type: research

MicroRNA-149 Suppresses Inflammation in Nucleus Pulposus Cells of Intervertebral Discs by Regulating MyD88.
CONCLUSIONS miR-149 can inhibit the inflammatory response mediated by LPS in NP cells, and might be a potential target for the treatment of IDD. PMID: 31263091 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - July 4, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Relationship Between IL-10 Gene Polymorphism and Spinal Tuberculosis.
Authors: Ma J, Lv Z, Wang J, Lu J Abstract BACKGROUND To investigate the relation between interleukin-10 (IL-10) gene rs1800871 (A/G) polymorphism and spinal tuberculosis. MATERIAL AND METHODS A total of 129 patients with spinal tuberculosis (spinal tuberculosis group) and 106 healthy subjects receiving physical examination (control group) were enrolled in this study. The general data of these subjects were collected, and the C-reactive protein, erythrocyte sedimentation rate (ESR) and baseline hematologic function were examined. The rs1800871 (A/G) polymorphism in IL-10 gene was detected by TaqMan-MGB probe method...
Source: Medical Science Monitor - July 4, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Protective Effect of Alendronate on Lumbar Facet Degeneration in Ovariectomized Rats.
CONCLUSIONS Treatment with ALN suppressed bone loss, subchondral bone architecture deterioration, and cartilage degeneration in OVX rats, which can be explained by roles of ALN in preservation of subchondral bone mass and microarchitecture, and counteraction of catabolism and chondrocyte apoptosis in cartilage. PMID: 31265447 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - July 4, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Quantitative Analysis of Foot Plantar Pressure During Walking.
CONCLUSIONS Use of the ITE System creates a new possibility for dynamic foot evaluation, drawing from pedobarography and methods of gait analysis. The proposed data analysis algorithm is simple and can be applied in all cases. Normally, 30% of the sum of all pressures during stance phase falls on the rearfoot; 39% falls on forefoot. PMID: 31266932 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - July 4, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Levetiracetam Protects Against Cognitive Impairment of Subthreshold Convulsant Discharge Model Rats by Activating Protein Kinase C (PKC)-Growth-Associated Protein 43 (GAP-43)-Calmodulin-Dependent Protein Kinase (CaMK) Signal Transduction Pathway.
This study aimed to investigate the effect of levetiracetam (LEV), an anti-convulsant drug, on cognitive impairment of SCD model rats and to assess the associated mechanisms. MATERIAL AND METHODS A SCD rat model was established. Rats were divided into an SCD group, an SCD+ sodium valproate (VPA) group, and an SCD+ levetiracetam (LEV) group. The Morris water maze was used to evaluate the capacity of positioning navigation and space exploration. The field excitatory post-synaptic potentials (fEPSPs) were evaluated using a bipolar stimulation electrode. NCAM, GAP43, PS95, and CaMK II levels were detected using Western blot an...
Source: Medical Science Monitor - July 4, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Research on the Potential Mechanism of Gypenosides on Treating Thyroid-Associated Ophthalmopathy Based on Network Pharmacology.
This study indicates that target genes mainly enriched in JAK-STAT signaling pathway, particularly in STATs, which can be combined with gypenosides. This may suggest that gypenosides have curative effect on thyroid-associated ophthalmopathy via the JAK-STAT pathway. PMID: 31268042 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - July 4, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Management of Extracranial Carotid Artery Aneurysms: A 6-Year Case Series.
CONCLUSIONS Open surgery was more frequently feasible in true aneurysms, and endovascular surgery was the first choice for false and dissecting aneurysms. Hybrid operation was available for complicated cases. The PUMCH classification may be helpful for selection of management strategies for ECAAs. PMID: 31269009 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - July 4, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Association Between Body Mass Index and Results of Rehabilitation in Patients After Stroke: A 3-Month Observational Follow-Up Study.
CONCLUSIONS Following hospital-based rehabilitation, patients with normal body mass achieved greater functional efficiency. The findings also show a trend towards normalization of BMI. The positive effect of rehabilitation was sustained for 3 months (Exam III), which may contribute to decreased risk of cardiovascular diseases and complications such as stroke. PMID: 31257360 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - July 3, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Effects of Vitamin A on Expressions of Apoptosis Genes Bax and Bcl-2 in Epithelial Cells of Corneal Tissues Induced by Benzalkonium Chloride in Mice with Dry Eye.
Authors: Zhang W, Li W, Zhang C, Zhu C, Yi X, Zhou Y, Lv Y Abstract BACKGROUND The apoptosis of corneal epithelial cells participates in the pathological processes of dry eye, which is expected to be a treatment target for dry eye. The aim of this study was to investigate the effects of vitamin A (VA) on apoptosis of corneal epithelial cells in a mouse model with dry eye induced by benzalkonium chloride (BAC). MATERIAL AND METHODS We randomly divided 60 male BALB/c mice aged 8-10 weeks into 3 groups: the blank control group, the dry eye + vehicle group, and the dry eye + drug group. On the 7th day after the dry eye...
Source: Medical Science Monitor - July 3, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Exosomes Derived From T Regulatory Cells Suppress CD8+ Cytotoxic T Lymphocyte Proliferation and Prolong Liver Allograft Survival.
CONCLUSIONS CD4+CD25+ Treg cells-derived EXOs could become an alternative tool for manipulating the immune system to discover novel underlying immunomodulatory mechanisms. PMID: 31258152 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - July 3, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Biomechanical Effects of Fixation of Different Segments of Goat Lumbar Spine on Adjacent Segmental Motion and Intradiscal Pressure Change.
Authors: Mu X, Li Z, Yin D, Liang B, Ou Y, Wei J Abstract BACKGROUND The aim of this study was to investigate the biomechanical fixation effects of different segments of the goat spine on adjacent segmental motion and intradiscal pressure (IDP) change. MATERIAL AND METHODS Eighteen goat spine specimens were randomly divided into 3 groups: group A (single-segment fixation), group B (double-segment fixation), and group C (triple-segment fixation). The motion was tested on each specimen using a spinal motion simulation test system with rational pressure loading. The IDP was measured using a pinhole pressure sensor. RE...
Source: Medical Science Monitor - July 3, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Cyclic Stretch Promotes Proliferation and Contraction of Human Bladder Smooth Muscle Cells by Cajal-Mediated c-kit Expression in Interstitial Cells.
CONCLUSIONS We revealed that ICCs could promote hBSMC proliferation and contraction, and cyclic stretch could promote acetylcholine receptor M2 and M3 caused by c-kit in the ICCs, which promoted the contraction of hBSMCs. PMID: 31249285 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - July 1, 2019 Category: Research Tags: Med Sci Monit Source Type: research