Epidemiology and Outcome Analysis of 470 Patients with Hand Burns: A Five-Year Retrospective Study in a Major Burn Center in Southwest China.
CONCLUSIONS The findings suggest that in Southwest China, prevention programs for children aged 0-9 years, injuries occurring in winter and non-workplace sites, and fire burns were imperative. PMID: 32417848 [PubMed - as supplied by publisher] (Source: Medical Science Monitor)
Source: Medical Science Monitor - May 19, 2020 Category: Research Tags: Med Sci Monit Source Type: research

A Population-Based Analysis of Distant Metastasis in Stage IV Gastric Cancer.
CONCLUSIONS Initial DM was found in 32.6% of patients with gastric cancer. Homogenous and heterogenous predictive factors were identified for patients with a specific metastatic site, which can be used in targeted screening and individualized treatment. PMID: 32409630 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - May 17, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Association Between Outdoor Activity and Insufficient Sleep in Chinese School-Aged Children.
Authors: Luo J, Cao M, Sun F, Shi B, Wang X, Jing J Abstract BACKGROUND The aim of this study was to explore the relationship between outdoor activity (OA) and insufficient sleep duration (ISD) among Chinese children and to assess the potential age- and gender-specific effects. MATERIAL AND METHODS A national sample of 62 517 children aged 6-17 years were recruited from 7 provinces of China in the autumn of 2013. Children and their caregivers reported daily sleep duration (
Source: Medical Science Monitor - May 17, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Comparison of Bone Remodeling Between Collum Femoris-Preserving Stems and Ribbed Stems in 1-Stage Bilateral Total Hip Arthroplasty.
This study examined a cohort of patients who underwent bilateral THAs. CFP prostheses and ribbed prostheses were each used on both sides. We assessed the midterm clinical, radiological, and bone remodeling outcomes around prosthesis of these patients. MATERIAL AND METHODS From January 2009 to January 2013, 53 patients were enrolled in our study. We clinically evaluated all patients by recording Harris hip and Oxford hip scores. Some radiological indicators of the femoral prosthesis position were measured. Periprosthetic bone remodeling was assessed via bone mineral density (BMD) measurements. RESULTS The mean preoperative ...
Source: Medical Science Monitor - May 17, 2020 Category: Research Tags: Med Sci Monit Source Type: research

The Comparative Analysis of Antegrade Versus Retrograde Approach for a Failed Porous Tantalum Rod Removal During Conversion to Total Hip Arthroplasty.
CONCLUSIONS The risk of conversion to THA following failed tantalum rod implantation is high. In such cases, the antegrade procedure was found to be a simple and efficient method for removing the trabecular metal rod with the use of a trephine. PMID: 32404862 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - May 16, 2020 Category: Research Tags: Med Sci Monit Source Type: research

miR-20a/Foxj2 Axis Mediates Growth and Metastasis of Colorectal Cancer Cells as Identified by Integrated Analysis.
CONCLUSIONS Our results showing the roles of miR-20a/Foxj2 in carcinogenesis of CRC may help improve treatment of CRC. PMID: 32406388 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - May 16, 2020 Category: Research Tags: Med Sci Monit Source Type: research

The Safety and Effectiveness of Laparoscopic versus Open Surgery for Congenital Hypertrophic Pyloric Stenosis in Infants.
CONCLUSIONS Laparoscopic pyloromyotomy has the same safety and effectiveness as the traditional operation and has the advantages of less trauma, faster recovery and cosmetically pleasing incisions. PMID: 32407297 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - May 16, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Gamma-Synuclein Levels Are Elevated in Peritoneal Fluid of Patients with Endometriosis.
CONCLUSIONS Levels of SNCG were statistically significantly higher in the peritoneal fluid of patients with endometriosis compared to disease-free controls, which may indicate its possible role the formation and progression of the disease. Moreover, its biological function should be further investigated due to the conflicting results concerning its expression in healthy tissues. PMID: 32393729 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - May 14, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Effects of Endovascular Stent-Assisted Effects of Various Frequencies of Abdominal Naprapathy on Changes in Gastrointestinal Mucosal Cells in Spleen-Deficient Rabbits.
CONCLUSIONS The abdominal naprapathy, especially with frequency of 101~150 times/min, repairs gastrointestinal mucosal injury of spleen-deficiency rabbits. PMID: 32394977 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - May 14, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Outcomes Following Arthroscopic Single and Double Bundle Anterior Cruciate Ligament (ACL) Reconstruction Supported by the Comprehensive Early Rehabilitation Program (CERP).
This study included 94 patients who had rehabilitation with CERP after knee surgery for a knee injury from a recreational sport. There were 49 patients in Group 1 (mean age, 36.5 years) who had CERP after SB ACLR, and 45 patients in Group 2 (mean age, 35.6 years) who had CERP after DB ACLR. Functional condition was tested using the Lysholm Knee Scoring Scale, and knee stability was measured using KT-2000. The first examination was performed before CERP and the second examination was performed 12 weeks later. RESULTS The level of functional condition in both groups was similar before rehabilitation with CERP, with no significant difference (P
Source: Medical Science Monitor - May 14, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Bacterial Characteristics in Intestinal Contents of Antibiotic-Associated Diarrhea Mice Treated with Qiweibaizhu Powder.
CONCLUSIONS These results indicated that QWBZP improved the diarrhea syndrome with restoring the diversity and adjusting the structures of bacteria in mice intestine, which might reveal the therapeutic mechanism of QWBZP on treating AAD. PMID: 32398636 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - May 14, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Efficacy of Eutectic Mixture of Local Anesthetics on Pain Control During Extracorporeal Shock Wave Lithotripsy: A Systematic Review and Meta-Analysis.
Authors: Huang Y, Chai S, Wang D, Li W, Zhang X Abstract BACKGROUND The efficacy of a eutectic mixture of local anesthetics (EMLA) for pain control in extracorporeal shock wave lithotripsy is unclear. The aim of this study was to assess the effect of EMLA cream on pain control during extracorporeal shock wave lithotripsy. MATERIAL AND METHODS We searched Medline, EMBASE, and the Cochrane Central Register of Controlled Trials to identify relevant randomized controlled trials that compared the pain control efficacies of EMLA vs. placebo. Study eligibility criteria, participants, and interventions: Randomized controll...
Source: Medical Science Monitor - May 14, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Influences of UGT2B7 rs7439366 and rs12233719 Polymorphisms on Fentanyl Sensitivity in Chinese Gynecologic Patients.
CONCLUSIONS Gynecologic patients with rs7439366 TT genotype had significantly lower fentanyl sensitivity than the other 2 genotype carriers. PMID: 32401749 [PubMed - as supplied by publisher] (Source: Medical Science Monitor)
Source: Medical Science Monitor - May 14, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Bioinformatics Analysis and High-Throughput Sequencing to Identify Differentially Expressed Genes in Nebulin Gene (NEB) Mutations Mice.
CONCLUSIONS Our data indicate that the expression of some cancer-driving genes and cancer suppressor genes are significantly changed in NEB mutant mice compared to wild-type mice, which suggests that NEB function plays an important role in regulating the expression of cancer-related genes in the thyroid gland. PMID: 32390000 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - May 13, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Effects of Endovascular Stent-Assisted Angioplasty on Cellular Metabolism in the Hippocampus of Elderly Patients with Symptomatic Vertebrobasilar Artery Stenosis.
This study explored the effect of angioplasty on cellular metabolism in the hippocampus of elderly patients with symptomatic vertebrobasilar artery stenosis. MATERIAL AND METHODS Eighteen elderly patients with symptomatic vertebrobasilar artery stenosis who underwent endovascular stent-assisted angioplasty (ESAA) in our department were studied. The changes in cellular metabolism (NAA / Cr, CHO / Cr, NAA / CHO) in bilateral hippocampal areas were detected by MRS before and at 6 months and 12 months after the ESAA. The Montreal Cognitive Assessment Scale (MoCA), Hamilton Depression Self-assessment Scale (HAMD), and Hamilton ...
Source: Medical Science Monitor - May 13, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Glutathione Peroxidase 8 as a Prognostic Biomarker of Gastric Cancer: An Analysis of The Cancer Genome Atlas (TCGA) Data.
CONCLUSIONS The expression of GPX8 may have prognostic relevance, being positively associated with worse OS in GC patients. PMID: 32392186 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - May 13, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Comprehensive Analysis of Fibroblast Growth Factor Receptor (FGFR) Family Genes in Breast Cancer by Integrating Online Databases and Bioinformatics.
CONCLUSIONS Our study comprehensively analyzed the prognostic values of FGFR1-4 expression in BC and proposed FGFR2 might serve as a promising biomarker. However, the underlying mechanisms remain to be elucidated. PMID: 32381997 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - May 11, 2020 Category: Research Tags: Med Sci Monit Source Type: research

A Model to Predict Treatment Failure of Single ‑Dose Methotrexate in Patients with Tubal Pregnancy.
CONCLUSIONS This model indicated good accuracy in predicting methotrexate treatment failure for tubal pregnancy patients. PMID: 32383438 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - May 11, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Differential Metabolic Pathways and Metabolites in a C57BL/6J Mouse Model of Alcoholic Liver Disease.
CONCLUSIONS The findings of the present study reveal potential biomarkers of ALD, and provide further insights into the pathogenesis of ALD. PMID: 32384076 [PubMed - as supplied by publisher] (Source: Medical Science Monitor)
Source: Medical Science Monitor - May 11, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Current State of Knowledge About SARS-CoV-2 and COVID-19 Disease in Pregnant Women.
Authors: Gujski M, Humeniuk E, Bojar I Abstract During any epidemic of infectious diseases, pregnant women constitute an extremely sensitive group due to altered physiology and immune functions, and thus altered susceptibility to infection. With regard to the management of pregnant COVID-19 patients, in addition to the treatment of the infection itself, which is not that different from generally accepted principles, it is interesting to consider which obstetric procedures should be used to minimize the adverse effects on mother and child. Questions arise concerning the continuation of pregnancy, how to terminate th...
Source: Medical Science Monitor - May 11, 2020 Category: Research Tags: Med Sci Monit Source Type: research

The Retropancreatic Fusion Fascia Oriented Splenic Hilar Lymphadenectomy Versus Laparoscopic Approach In D2 Total Gastrectomy.
This study aimed to develop the retropancreatic fusion fascia-oriented ex vivo approach for splenic hilar lymphadenectomy (RP-SL) to avoid difficulty in using the total laparoscopic approach (TL-SL). MATERIAL AND METHODS The data for patients with PAGC who underwent D2 total gastrectomy were retrieved from our clinical database and electronic medical records (December 2016 to December 2018), with a 1:1 match ratio for balance of the 2 groups. RESULTS In sum, 84 matched patients were included in the study. There were 2360 retrieved lymph nodes (LNs), with an average of 28.10. Sixteen patients were confirmed with positive sp...
Source: Medical Science Monitor - May 11, 2020 Category: Research Tags: Med Sci Monit Source Type: research

CircPSMC3 Suppresses Migration and Invasion of Non-Small Cell Lung Cancer Cells via miR-182-5p/NME2 Axis.
CONCLUSIONS CircPSMC3 inhibits the invasion and migration of NSCLC cells through the miR-182-5p/NME2 signaling pathway. PMID: 32386284 [PubMed - as supplied by publisher] (Source: Medical Science Monitor)
Source: Medical Science Monitor - May 11, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Secondary "Hybrid Reconstruction" Concept with Silicone Implants After Autologous Breast Reconstruction - Is It Safe and Reasonable?
CONCLUSIONS The demonstrated "Hybrid Breast Reconstruction" approach, using an implant underneath a free flap autologous breast reconstruction, provided a safe and reliable option to optimize breast reconstruction outcomes. PMID: 32388530 [PubMed - as supplied by publisher] (Source: Medical Science Monitor)
Source: Medical Science Monitor - May 11, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Epicardial Adipose Tissue Predicts Severe Mitral Annular Calcification in Patients Aged ≥60 Years.
Epicardial Adipose Tissue Predicts Severe Mitral Annular Calcification in Patients Aged ≥60 Years. Med Sci Monit. 2020 May 10;26:e921553 Authors: Argan O, Avci E, Safak O, Yildirim T Abstract BACKGROUND Epicardial adipose tissue (EAT) has been shown to be associated with diabetes mellitus (DM), hypertension (HT), coronary artery calcification, and atherosclerotic disease. Mitral annular calcification (MAC) is also associated with atherosclerosis. The purpose of this study was to assess the relationship between EAT and severe MAC. MATERIAL AND METHODS The study enrolled 102 patients who had severe MA...
Source: Medical Science Monitor - May 11, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Dietary Melatonin Therapy Alleviates the Lamina Cribrosa Damages in Patients with Mild Cognitive Impairments: A Double-Blinded, Randomized Controlled Study.
This study aimed to investigate the melatonin induced effects on the lamina cribrosa thickness (LCT) of patients with MCI. MATERIAL AND METHODS The LCT data of patients with MCI were compared to LCT data of healthy controls. Subsequently, all MCI patients were randomly assigned into an experimental group (with melatonin treatment) or a placebo group (without any melatonin treatment). RESULTS The LCT of MCI patients decreased significantly compared with healthy controls. The univariate analysis showed that the lower the Mini Mental State Examination (MMSE) score (P=0.038; 95% CI: 0.876, -0.209), the smaller hippocampus volu...
Source: Medical Science Monitor - May 9, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Dietary Calcium Intake and HPV Infection Status Among American Women: A Secondary Analysis from National Health and Nutrition Examination Survey (NHANES) Data Set of 2003  - 2016.
CONCLUSIONS At the range of 3.32-9.78 of log2 calcium intake, DCa intake was negatively correlated with HPV infection. After this interval, DCa intake was not associated with the risk of HPV infection. PMID: 32378682 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - May 9, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Epidemiological Analysis of the First 1389 Cases of COVID-19 in Poland: A Preliminary Report.
CONCLUSIONS The proportion of women and men with confirmed COVID-19 infection was similar to the sex ratio in the general population. Infections were relatively less common in those aged under 20 years. The largest numbers of confirmed cases were detected in 3 of the 4 largest cities, each of which has an international airport. PMID: 32379726 [PubMed - as supplied by publisher] (Source: Medical Science Monitor)
Source: Medical Science Monitor - May 9, 2020 Category: Research Tags: Med Sci Monit Source Type: research

An Evidence Based Perspective on mRNA-SARS-CoV-2 Vaccine Development.
Authors: Wang F, Kream RM, Stefano GB Abstract The first outbreak of coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) occurred in Wuhan, Hubei Province, China, in late 2019. The subsequent COVID-19 pandemic rapidly affected the health and economy of the world. The global approach to the pandemic was to isolate populations to reduce the spread of this deadly virus while vaccines began to be developed. In March 2020, the first phase I clinical trial of a novel lipid nanoparticle (LNP)-encapsulated mRNA-based vaccine, mRNA-1273, which encodes the spike prot...
Source: Medical Science Monitor - May 7, 2020 Category: Research Tags: Med Sci Monit Source Type: research

COVID-19 Dynamic Computed Tomography (CT) Performance and Observation of Some Laboratory Indicators.
CONCLUSIONS The dynamic changes of CT images of lungs of COVID-19 patients, combined with the clinical manifestations and laboratory indicators of patients, can help guide clinical diagnosis and treatment. PMID: 32367888 [PubMed - indexed for MEDLINE] (Source: Medical Science Monitor)
Source: Medical Science Monitor - May 7, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Exosomes Derived from Bone Marrow Stromal Cells (BMSCs) Enhance Tendon-Bone Healing by Regulating Macrophage Polarization.
CONCLUSIONS Our study provides evidence that the local administration of BMSC-Exos promotes the formation of fibrocartilage by increasing M2 macrophage polarization in tendon-to-bone healing, leading to improved biomechanical properties. These findings provide a basis for the potential clinical use of BMSC-Exos in tendon-bone repair. PMID: 32369458 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - May 7, 2020 Category: Research Tags: Med Sci Monit Source Type: research

A Comparative Study of Conservation, Endovascular Embolization Therapy, and Surgery for Blunt Renal Trauma.
CONCLUSIONS The success rate of angioembolization was high and protected renal function to the greatest extent, and there were no differences in renal function at long-term follow-up. However, it is difficult to manage renal vessel laceration or avulsion by embolization alone, and various endovascular therapies are required to protect the function of residual kidneys. PMID: 32372763 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - May 7, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Inhibition Effect of Dictyophora Polysaccharides on Human Hepatocellular Carcinoma Cell Line HCC-LM3.
CONCLUSIONS To the best of our knowledge, this is the first published study on the mechanism of Dictyophora polysaccharide inhibition of HCC-LM3 cell proliferation. PMID: 32374722 [PubMed - as supplied by publisher] (Source: Medical Science Monitor)
Source: Medical Science Monitor - May 7, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Oridonin Alleviates IRI-Induced Kidney Injury by Inhibiting Inflammatory Response of Macrophages via AKT-Related Pathways.
CONCLUSIONS Oridonin ameliorates AKI kidney injuries by suppressing AKT-mediated inflammatory response of macrophages. PMID: 32362652 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - May 6, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Effect of a Specific Questionnaire Sheet on Subclassification of Osteonecrosis of the Femoral Head.
CONCLUSIONS The use of a specific questionnaire sheet can change the distribution of ONFH subclassifications compared with use of a conventional medical history interview. Use of a specific questionnaire sheet can allow for more detailed self-reporting regarding potential causative factors for nontraumatic ONFH, especially habitual alcohol intake. PMID: 32364184 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - May 6, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Effective Chemotherapy of Lung Cancer Using Bovine Serum Albumin-Coated Hydroxyapatite Nanoparticles.
CONCLUSIONS Our hybrid DDS shows potential to be applied in more advanced application of cancer therapy. PMID: 32365057 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - May 6, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Changes in Foot Skin Microbiome of Patients with Diabetes Mellitus Using High-Throughput 16S rRNA Gene Sequencing: A Case Control Study from a Single Center.
This study aimed to use high-throughput 16S rRNA gene sequencing to investigate the changes in foot skin microbiome of patients with diabetes mellitus from a single center in China. MATERIAL AND METHODS Fifty-two participants were divided into 4 study groups: healthy controls (n=13); patients with short-term diabetes (10 years; n=13). Swabs were analyzed from the intact skin of the foot arch using high-throughput 16S ribosomal RNA sequencing. RESULTS Microbiome phylogenic diversity varied significantly between the study groups (whole tree, P
Source: Medical Science Monitor - May 4, 2020 Category: Research Tags: Med Sci Monit Source Type: research

The Main Bottleneck for Non-Metastatic Pancreatic Adenocarcinoma in Past Decades: A Population-Based Analysis.
CONCLUSIONS The development of chemotherapy and radiotherapy has been slow, especially for unresectable PDAC. Although advances in surgery contributed significantly to improved survival for resectable PDAC, lack of early diagnostic tools, which lead to low resection rates, remain a barrier for all PDAC patients. PMID: 32358953 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - May 4, 2020 Category: Research Tags: Med Sci Monit Source Type: research

The AGT Haplotype of the ESR2 Gene Containing the Polymorphisms rs2077647A, rs4986938G, and rs1256049T Increases the Susceptibility of Unexplained Recurrent Spontaneous Abortion in Women in the Chinese Hui Population.
CONCLUSIONS The AGT haplotype of the ESR2 gene containing the polymorphism rs2077647A, rs4986938G, and rs1256049T (ESR2 hapAGT) was a protective factor for URSA in women in the Chinese Hui population when compared with the Chinese Han population. PMID: 32359133 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - May 4, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Inhibition of MiR-10b Restrains the Migration and Epithelial-Mesenchymal Transition of Lung Cells by Targeting LATS2 via TAZ Pathway.
CONCLUSIONS MiR-10b was upregulated in lung cancer. Inhibition of miR-10b could restrain the development of lung cancer by increasing LATS2 expression via TAZ. PMID: 32361707 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - May 4, 2020 Category: Research Tags: Med Sci Monit Source Type: research

The Effects of microRNA-515-5p on the Toll-Like Receptor 4 (TLR4)/JNK Signaling Pathway and WNT1-Inducible-Signaling Pathway Protein 1 (WISP-1) Expression in Rheumatoid Arthritis Fibroblast-Like Synovial (RAFLS) Cells Following Treatment with Receptor Activator of Nuclear Factor-kappa-B Ligand (RANKL).
CONCLUSIONS In RAFLS cells, miR-515-5p inhibited the expression of the WISP1 gene, and treatment with RANKL inhibited the TLR4/JNK signaling pathway. PMID: 32361708 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - May 4, 2020 Category: Research Tags: Med Sci Monit Source Type: research

RUNX3 Polymorphisms Affect the Risk of Ankylosing Spondylitis.
CONCLUSIONS RUNX3 rs760805 polymorphism can contribute to AS incidence in Chinese Han people. The interaction of the 2 polymorphisms may be a risk factor for AS. PMID: 32355155 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - May 3, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Application of Insertable Cardiac Monitor in Establishing a Dog Model of Atrial Fibrillation by High-Frequency Right Atrial Pacing.
CONCLUSIONS The application of insertable cardiac monitor Reveal LINQ improves the efficiency of monitoring the AF load, with high sensitivity, convenience, and accuracy. PMID: 32356526 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - May 3, 2020 Category: Research Tags: Med Sci Monit Source Type: research

The Effect of Long Non-Coding RNA (lncRNA) HCP5 on Regulating Epithelial-Mesenchymal Transition (EMT)-Related Markers in Gastric Carcinoma Is Partially Reversed by miR-27b-3p.
CONCLUSIONS The effect of silencing HCP5 on repressing GC cells viability and metastasis by regulating EMT-associated markers can be partially reversed by miR-27b-3p inhibitor. PMID: 32357145 [PubMed - as supplied by publisher] (Source: Medical Science Monitor)
Source: Medical Science Monitor - May 3, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Research Progress of N6-Methyladenosine in the Cardiovascular System.
Authors: Zheng N, Su J, Hu H, Wang J, Chen X Abstract According to the World Health Organization cardiovascular disease risk charts, the mortality rate of cardiovascular diseases in people is still high. The medical expenses caused by cardiovascular diseases are increasing daily, and the medical burden is becoming heavier; as such, it is imperative to prevent and cure cardiovascular diseases. A large number of scholars are analyzing the pathogenesis of cardiovascular diseases from various perspectives. Recent findings suggest that N6-methyladenosine (m6A) plays a multifaceted role in the cardiovascular system. m6A ...
Source: Medical Science Monitor - May 1, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Carbon Monoxide Inhibits the Expression of Proteins Associated with Intestinal Mucosal Pyroptosis in a Rat Model of Sepsis Induced by Cecal Ligation and Puncture.
CONCLUSIONS In a rat model of sepsis induced by CLP, CO had a protective role by inhibiting intestinal mucosal pyroptosis. PMID: 32351244 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - May 1, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Comparison of Efficacies of Commonly Used Hypertension Treatment Modalities: A Retrospective Study of 1900 Participants in a Hypertension Clinic.
Authors: Zhao X, Dahal A, Yang Q, Yang Y, Ding Z, Wang J, Swai JD, Jiang W, Li X Abstract BACKGROUND Although various antihypertensive medications are available, some hypertensive patients have uncontrolled blood pressures, especially in the clinic. The aim of the present study was to compare the efficacies of various antihypertensive therapies in our hypertension (HTN) clinic (monotherapy vs. combination therapy, fixed-dose combination (FDC) versus free equivalent combination (FEC), and diuretics versus non-diuretics. MATERIAL AND METHODS In this retrospective study, patients at the HTN clinic of the Third Xiangya...
Source: Medical Science Monitor - May 1, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Apoptosis Activation in Thyroid Cancer Cells by Jatrorrhizine-Platinum(II) Complex via Downregulation of PI3K/AKT/Mammalian Target of Rapamycin (mTOR) Pathway.
CONCLUSIONS The JR-P(II) induced cytotoxicity in thyroid cancer cells by inhibiting the mechanism responsible for repair of double-stranded DNA. The in vivo data also revealed that JR-P(II) effectively inhibits thyroid tumor growth by inducing DNA damage. Thus, our results suggest that further evaluation of JR-P(II) as a therapeutic candidate for thyroid cancer is warranted. PMID: 32341329 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - April 30, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Icariin Promotes Fracture Healing in Ovariectomized Rats.
CONCLUSIONS These results revealed that icariin could promote fracture healing in ovariectomized rats via OPG/RANKL signaling, and that serum E₂ and uterine index were not affected by icariin treatment. PMID: 32342947 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - April 30, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Silencing Signal Transducer and Activator of Transcription 3 (STAT3) and Use of Anti-Programmed Cell Death-Ligand 1 (PD-L1) Antibody Induces Immune Response and Anti-Tumor Activity.
CONCLUSIONS Silencing STAT3 and PD-L1 antibody injection in combination increased apoptosis in tumor cells and thus offers better anti-cancer activity. PMID: 32343679 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - April 30, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Clinical Outcomes of Intraoperative Contrast-Enhanced Ultrasound Compared with Intraoperative Neurophysiological Monitoring During Circumferential Decompression for Myelopathy Associated with Thoracic-Ossification of the Posterior Longitudinal Ligament.
This study is the first to describe the use of contrast-enhanced ultrasound (CEUS) to evaluate the spinal cord blood flow (SCBF) during thoracic spine surgery in humans. The objective of this study was to compare clinical outcomes between intraoperative CEUS and IONM during CD. MATERIAL AND METHODS Sixty-eight T-OPLL patients who received CD from 2007 to 2014 were reviewed. All patients underwent IONM. CEUS was used on the following 2 occasions on 18 patients to evaluate SCBF: the first measurement was performed after laminectomy and the second after ventral decompression. Outcomes were evaluated by the Hirabayashi recover...
Source: Medical Science Monitor - April 30, 2020 Category: Research Tags: Med Sci Monit Source Type: research