A Predictive Nomogram for Early Mortality in Stage IV Gastric Cancer.
CONCLUSIONS The nomogram models proved to be a suitable tool for predicting the early mortality in stage IV gastric cancer. PMID: 32813682 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 21, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Ginkgo biloba Extract EGb761 Attenuates Bleomycin-Induced Experimental Pulmonary Fibrosis in Mice by Regulating the Balance of M1/M2 Macrophages and Nuclear Factor Kappa B (NF- κB)-Mediated Cellular Apoptosis.
CONCLUSIONS This study illustrated the protective effect of EGb761 on BLM-induced PF by regulating the balance of M1/M2 macrophages and NF-kappaB (p65)-mediated apoptosis. The results demonstrated the potential clinical therapeutic effect of EGb761, providing a novel possibility for curing PF. PMID: 32799214 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 19, 2020 Category: Research Tags: Med Sci Monit Source Type: research

The Evaluation of Bone Mineral Density based on Age and Anthropometric Parameters in Southeast Chinese Adults: A Cross-Sectional Study.
CONCLUSIONS Age, anthropometric parameters and BMD correlate differently between groups and genders in southeast Chinese adults. PMID: 32799215 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 19, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Performance of Double-Arm Digital Subtraction Angiography (DSA)-Guided and C-Arm-Guided Percutaneous Kyphoplasty (PKP) to Treat Senile Osteoporotic Vertebral Compression Fractures.
Authors: Ban J, Peng L, Li P, Liu Y, Zhou T, Xu G, Zhang X Abstract BACKGROUND Osteoporotic vertebral compression fracture (OVCF) is a common fracture in the elderly. Conservative treatment requires prolonged bedding, which may lead to serious complications. To explore optimized use of percutaneous kyphoplasty (PKP) in the treatment of senile osteoporotic thoracolumbar vertebral compression fractures, in this study, we used C-arm-guided and double-arm digital subtraction angiography (DSA)-guided PKP to treat OVCF in elderly patients and analyzed the effective recovery. MATERIAL AND METHODS In all, 60 patients who p...
Source: Medical Science Monitor - August 19, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Evaluation of Ovarian Tumors with Multidetector Computed Tomography and Tumor Markers: Differentiation of Stage I Serous Borderline Tumors and Stage I Serous Malignant Tumors Presenting as Solid-Cystic Mass.
CONCLUSIONS Age, vascular abnormalities, and the maximum diameter of the solid portion were independent factors for differentiating SBOTs from SMOTs. The combined analysis of age, vascular abnormalities, and the maximum diameter of the solid portion may allow better differentiation between SBOTs and SMOTs. PMID: 32801292 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 19, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Omipalisib Inhibits Esophageal Squamous Cell Carcinoma Growth Through Inactivation of Phosphoinositide 3-Kinase (PI3K)/AKT/Mammalian Target of Rapamycin (mTOR) and ERK Signaling.
CONCLUSIONS Omipalisib inhibited the proliferation and growth of ESCC by disrupting PI3K/AKT/mTOR and ERK signaling. The present study supports the rationale for using omipalisib as a therapeutic approach in ESCC patients. Further clinical studies are needed. PMID: 32804918 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 19, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Risk Factors for Acquisition of Carbapenem-Resistant Klebsiella pneumoniae and Mortality Among Abdominal Solid Organ Transplant Recipients with K. pneumoniae Infections.
CONCLUSIONS K. pneumoniae infections, especially CRKP, frequently occurred among ASOT recipients, with a high mortality rate. Multiple infected organs or sites and septic shock were predictors of crude mortality caused by K. pneumoniae infections, while CRKP infections were associated with multiple infected organs or sites. Greater efforts are needed towards improved antibiotic administration, early diagnosis and precise treatment, recognition of septic shock, and reduced length of hospitalization. PMID: 32807765 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 19, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Effects of a Secondary Prevention Combination Therapy with beta-Blocker and Statin on Major Adverse Cardiovascular Events in Acute Coronary Syndrome Patients.
Authors: Zhu L, Cui Q, Liu Y, Liu Z, Zhang Y, Liu F, Wang J Abstract BACKGROUND The efficacy of a beta-blocker or statin alone versus combination therapy is uncertain. We compared the effects of a combination of beta-blocker and statin with those of one-drug therapies with regard to the occurrence of a major adverse cardiovascular event (MACE) in patients with acute coronary syndrome (ACS). MATERIAL AND METHODS From 2011 to 2013, 636 ACS patients were included. Based on their risk category, enrolled subjects were assigned into 4 groups receiving consistent beta-blocker and/or statin treatment: no therapy group (n=1...
Source: Medical Science Monitor - August 19, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Root Anatomy and Root Canal Morphology of Maxillary Second Permanent Molars in a Chongqing Population: A Cone-Beam Computed Tomography Study.
CONCLUSIONS The root form and canal shape of permanent second molars of the upper jaw varied greatly among the population of Chongqing, China. CBCT is a valuable method for assessing the complex anatomic morphology of teeth. PMID: 32810082 [PubMed - as supplied by publisher] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 19, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Characteristics and Outcome of 69 Cases of Coronavirus Disease 2019 (COVID-19) in Lu'an City, China Between January and February 2020.
CONCLUSIONS The epidemic prevention and control in Lu'an City has achieved phased results. Yet, new strict control measures need to be implemented to prevent a further outbreak, especially for those who will return to Lu'an City. PMID: 32796810 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 18, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Visual Interpretability in Computer-Assisted Diagnosis of Thyroid Nodules Using Ultrasound Images.
CONCLUSIONS This study was an active exploration of interpretability in the deep learning classification of thyroid nodules. It demonstrated the neural network-visualized model focused on irregular nodule margins and the A/T ratio to classify thyroid nodules. PMID: 32798214 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 18, 2020 Category: Research Tags: Med Sci Monit Source Type: research

The Role of Chemotherapy in Extraskeletal Osteosarcoma: A Propensity Score Analysis of the Surveillance Epidemiology and End Results (SEER) Database.
CONCLUSIONS The study suggested that chemotherapy has no significant benefit on prognosis of patients with ESOS. These findings should be considered when making treatment decisions about patients with ESOS. PMID: 32792473 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 16, 2020 Category: Research Tags: Med Sci Monit Source Type: research

A Retrospective Study of Surgical Correction for Spinal Deformity with and without Osteotomy to Compare Outcome Using Intraoperative Neurophysiological Monitoring with Evoked Potentials.
CONCLUSIONS Intraoperative simultaneous SSEP/MEP can effectively reflect neurological function in non-osteotomy spinal surgery patients. Simultaneous SSEP/MEP/DNEP can effectively avoid the unnecessary interference by false-positive results of MEP during osteotomy. PMID: 32794474 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 16, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Effect of 2 Different Dosages of Rosuvastatin on Prognosis of Acute Myocardial Infarction Patients with New-Onset Atrial Fibrillation in Jinan, China.
CONCLUSIONS Treatment with rosuvastatin can reduce the serum lipid level and improve cardiac function. Different dosages of rosuvastatin, age, smoking, drinking alcohol, and diabetes are independent risk factors for AF and ischemia events. The results suggested it is safe to use 20 mg rosuvastatin in the 12 months after hospital admission. PMID: 32785210 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 15, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Infliximab for Crohn's Disease Patients with Perianal Fistulas: Better Image, Better Life.
Authors: Hong L, Zhang C, Fan R, Wang L, Wang Z, Zhang T, Zhong J Abstract BACKGROUND Patients with Crohn's disease (CD) experience physical impairments, poor quality of life and negative body image. These factors are exacerbated in CD patients with active perianal fistulas. MATERIAL AND METHODS Baseline characteristics were compared in retrospectively enrolled CD patients with and without active perianal fistulas. The relationships between improvements in perianal fistulas and quality of life, body image, and self-esteem were determined. The effects of infliximab treatment on improvement of psychological-social st...
Source: Medical Science Monitor - August 15, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Expression of Fibroblast Growth Factor 4 in a Rat Model of Polydactyly of the Thumb Induced by Cytarabine.
Authors: Zhao X, Yang W, Li G, Dong H, Hou J, Cao Z, Guan D Abstract BACKGROUND The aim of this study was to assess the expression and mechanisms of fibroblast growth factor 4 in polydactyly of the thumb induced by cytarabine. MATERIAL AND METHODS Rats were intraperitoneally injected with cytarabine at different gestation periods (12.5 days, 13.5 days, and 14.5 days) to establish a polydactyly of the thumb model. Then, the expression of FGF4 in polydactyly was studied by whole-mount in situ hybridization. We used hematoxylin & eosin stain and cartilage stain to investigate the development of the skeleton and ti...
Source: Medical Science Monitor - August 15, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Mixed Lineage Kinase Domain-Like Protein Promotes Human Monocyte Cell Adhesion to Human Umbilical Vein Endothelial Cells Via Upregulation of Intercellular Adhesion Molecule-1 Expression.
CONCLUSIONS MLKL can promote THP-1 cell adhesion to HUVECs through up-regulation of ICAM-1 expression in HUVECs. Thus, MLKL might be a useful target for reducing adhesion of monocytes to endothelial cells and atherosclerosis. PMID: 32788571 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 15, 2020 Category: Research Tags: Med Sci Monit Source Type: research

High versus Low Mechanical Index Imaging Diagnostic Ultrasound in Patients with Myocardial Infarction: A Therapeutic Application Study.
CONCLUSIONS High acoustic energy ultrasound is a safe method for diagnosis of ST-segment elevation myocardial infarction and may have therapeutic applications. PMID: 32790651 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 15, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Clinicopathological Analysis and Prognostic Assessment of Transcobalamin I (TCN1) in Patients with Colorectal Tumors.
CONCLUSIONS Although independent risk factors affecting survival of patients with CRC are age, serum CA125, CA19-9, lymph node metastasis, and nerve invasion, negative factors affecting overall 5-year survival in TCN1 should not be ignored, because its high expression suggests a worse clinical prognosis. PMID: 32753569 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 13, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Are There Lower Complication Rates with Bidirectional Barbed Suture in Total Knee Arthroplasty Incision Closure? A Randomized Clinical Trial.
Authors: Feng S, Zhang Y, Zhang F, Yang Z, Chen XY, Zha GC Abstract BACKGROUND The use of barbed suture in total knee arthroplasty (TKA) remains controversial. We performed a prospective study to investigate the clinical outcomes of bidirectional barbed suture for incision closure in TKA. MATERIAL AND METHODS We conducted a single-center, randomized controlled trial to determine the efficiency and safety of barbed suture in TKA at our institution between December 2017 and April 2019. Eligible patients were randomly assigned to different suture methods for skin closure. Randomization was conducted via computerized r...
Source: Medical Science Monitor - August 13, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Exosomes Mediated Transfer of Circ_UBE2D2 Enhances the Resistance of Breast Cancer to Tamoxifen by Binding to MiR-200a-3p.
CONCLUSIONS Exosomes mediated transfer of circ_UBE2D2 reinforced tamoxifen resistance in breast cancer by binding to miR-200a-3p, providing new insights into the boost of the effectiveness of tamoxifen on breast cancer patients. PMID: 32756532 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 13, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Integrated Analysis of Hub Genes and Pathways In Esophageal Carcinoma Based on NCBI's Gene Expression Omnibus (GEO) Database: A Bioinformatics Analysis.
CONCLUSIONS The signaling pathways involving the DEGs probably represent the pathological mechanism underlying ESCA. The hub genes were associated with survival of ESCA patients, and as such have the potential to serve as diagnostic indicators and therapeutic targets. PMID: 32756534 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 13, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Cyclin-Dependent Kinase 1 (CDK1) is Co-Expressed with CDCA5: Their Functions in Gastric Cancer Cell Line MGC-803.
CONCLUSIONS Co-expression of CDK1 and CDCA5 might confer cell proliferation, migration, and invasion abilities in GC cells, and this can provide some clues for further therapies of gastric tumors. PMID: 32759885 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 13, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Extracorporeal Membrane Oxygenation (ECMO) in Critically Ill Patients with Coronavirus Disease 2019 (COVID-19) Pneumonia and Acute Respiratory Distress Syndrome (ARDS).
This article reviews the pertinent clinical literature, technical guidance, and expert recommendations on use of ECMO in critically ill cases of COVID-19. Here, we present basic knowledge and opinions about COVID-19 and ECMO, review the evidence on ECMO use in Middle East Respiratory Syndrome (MERS) and H1N1 influenza, share the technical guidance and recommendations on use of ECMO in COVID-19, summarize the current use of ECMO against COVID-19 in China, and discuss the issues in use of ECMO in COVID-19. PMID: 32759887 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 13, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Elevated Lateral Position Improves the Success of Paramedian Approach Subarachnoid Puncture in Spinal Anesthesia before Hip Fracture Surgery in Elderly Patients: A Randomized Controlled Study.
Authors: Zhang W, Wang T, Wang G, Yuan Y, Zhou Y, Yang X, Yang M, Zheng S Abstract BACKGROUND The aim of this study was to determine whether an elevated lateral recumbent position, compared to regular lateral recumbent position, may reduce the number of needle passes and attempts required for success subarachnoid puncture in spinal aesthesia before surgery in elderly patients with hip fractures. MATERIAL AND METHODS This was a randomized controlled interventional study in Beijing Jishuitan Hospital. Patients older than 65 years of age with hip fracture orthopedics who were planned to receive subarachnoid block in t...
Source: Medical Science Monitor - August 13, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Reelin Promotes Cisplatin Resistance by Induction of Epithelial-Mesenchymal Transition via p38/GSK3 β/Snail Signaling in Non-Small Cell Lung Cancer.
CONCLUSIONS These data indicated that Reelin induces DDP resistance of NSCLC by regulation of the p38/GSK3ß/Snail/EMT signaling pathway and provide evidence that Reelin suppression can be an effective strategy to suppress DDP resistance in NSCLC. PMID: 32764530 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 13, 2020 Category: Research Tags: Med Sci Monit Source Type: research

The Release of Norepinephrine in C57BL/6J Mice Treated with 6-Hydroxydopamine (6-OHDA) is Associated with Translocations in Enteric Escherichia coli via the QseC Histidine Kinase Receptor.
CONCLUSIONS NE modulates the interaction of enteric bacterial pathogens with their hosts via QseC. The blockade of the QseC receptor-mediated effects may be useful to attenuate bacterial translocation. PMID: 32764532 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 13, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Risk Factors for Severe Complications After Laparoscopic Surgery for T3 or T4 Rectal Cancer for Chinese Patients: Experience from a Single Center.
CONCLUSIONS Preoperative high white blood cells, diabetes mellitus and pulmonary dysfunction were independent risk factors for severe complications after laparoscopic surgery for T3 or T4 rectal cancer. PMID: 32764534 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 13, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Value of Combination of Heart, Lung, and Diaphragm Ultrasound in Predicting Weaning Outcome of Mechanical Ventilation.
Authors: Xu X, Wu R, Zhang YJ, Li HW, He XH, Wang SM Abstract BACKGROUND Postextubation distress is detrimental to the prognosis of critically ill patients with successful spontaneous breathing trial. The known risk factors of failed weaning are associated with the heart, lungs, and diaphragm. The aim of this study was to explore the role of a combined model including indicators of heart, lung, and diaphragm ultrasound in predicting the weaning outcome. MATERIAL AND METHODS Patients' clinical data and ultrasonic features of heart, lungs, and diaphragm were recorded. Patients were included in either the failed weani...
Source: Medical Science Monitor - August 13, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Systematic Understanding of Mechanism of Yi-Qi-Huo-Xue Decoction Against Intracerebral Hemorrhagic Stroke Using a Network Pharmacology Approach.
CONCLUSIONS The present results may serve as a pharmacological framework for TCM studies in the future, helping to promote the use of YQHXD in clinical treatment of ICH. PMID: 32769962 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 13, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Protective Effect of Probiotics against Esophagogastric Variceal Rebleeding in Patients with Liver Cirrhosis after Endoscopic Therapy.
Authors: Zhang Q, Gao F, Yang X, Hu Y, Liu Y, Hou Y, Li Y, Zhu B, Niu S, Huang Y, Wang X Abstract BACKGROUND Probiotic therapy has been shown to be beneficial against some liver diseases. However, there is still uncertainty regarding the clinical efficacy of probiotics for the treatment of variceal rebleeding. This research explored the efficacy of probiotics in variceal rebleeding. MATERIAL AND METHODS This was a retrospective study of 704 consecutive patients with liver cirrhosis who recovered from esophagogastric variceal bleeding after endoscopic treatment. Patients were subdivided into a probiotics cohort (n=2...
Source: Medical Science Monitor - August 13, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Long Non-Coding RNA SNHG8 Plays a Key Role in Myocardial Infarction Through Affecting Hypoxia-Induced Cardiomyocyte Injury.
CONCLUSIONS We demonstrated that lncRNA SNHG8 affected myocardial infarction by affecting hypoxia-induced cardiomyocyte injury via regulation of the NF-kappaB pathway. PMID: 32772038 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 13, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Dishevelled Associated Activator Of Morphogenesis (DAAM) Facilitates Invasion of Hepatocellular Carcinoma by Upregulating Hypoxia-Inducible Factor 1 α (HIF-1α) Expression.
CONCLUSIONS DAAM2, rather than DAAM1, was able to predict prognosis of HCC. DAAM2 decreased VHL expression and consequently upregulated HIF-1alpha, eventually facilitating invasion of HCC. PMID: 32772041 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 13, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Locking Plates versus Locking Intramedullary Nails Fixation of Proximal Humeral Fractures Involving the Humeral Shaft: A Retrospective Cohort Study.
Authors: Song H, He T, Guo HY, Li ZY, Wei M, Zhang C, Dong YQ Abstract BACKGROUND For proximal humeral fractures (PHFs), locking intramedullary nails and locking plates have been widely used. However, few reports have been published on the therapy of complex PHFs accompanying humeral shaft fractures. Therefore, we performed this research to analyze the effectiveness of locking intramedullary nails and locking plates in the management of proximal humeral fractures involving the humeral shaft. MATERIAL AND METHODS We retrospectively reviewed 40 cases diagnosed with proximal humeral fractures involving the humeral sha...
Source: Medical Science Monitor - August 13, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Abnormal Fractional Amplitude of Low-Frequency Fluctuation Changes in Patients with Monocular Blindness: A Functional Magnetic Resonance Imaging (MRI) Study.
Authors: Fang JW, Yu YJ, Tang LY, Chen SY, Zhang MY, Sun T, Wu SN, Yu K, Li B, Shao Y Abstract BACKGROUND We used fractional amplitude of low-frequency fluctuation (fALFF) technology to investigate spontaneous cerebral activity in patients with monocular blindness (MB) and in healthy controls (HCs). MATERIAL AND METHODS Thirty MB patient and 15 HCs were included in this study. All subjects were scanned by resting-state functional magnetic resonance imaging (rs-fMRI). The independent sample t test and chi-squared test were applied to analyze demographics of MB patients and HCs. The 2-sample t test and receiver opera...
Source: Medical Science Monitor - August 13, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Preparation and Characterization of a Novel Triple Composite Scaffold Containing Silk Fiborin, Chitosan, and Alginate for 3D Culture of Colonic Carcinoma Cells In Vitro.
CONCLUSIONS This study successfully demonstrated the potential of SF/Cs/Alg (1: 1: 1) scaffold as an alternative for the 3D in vitro culture of CC cells. PMID: 32773734 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 13, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Silencing of Long Non-Coding RNA (lncRNA) Nuclear Paraspeckle Assembly Transcript 1 (NEAT1) Protects PC-12 Cells from LPS-Induced Injury via Targeting miR-29a.
CONCLUSIONS High NEAT1 levels can increase LPS-induced injury in PC-12 cells through the miR-29a/BCL2L11 pathway. lncRNA NEAT1 may, therefore, be a promising target for SCI treatment. PMID: 32776916 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 13, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Early Death Incidence and Prediction in Stage IV Breast Cancer.
CONCLUSIONS Nomograms were generated to predict early death, with good calibration and discrimination. The predictive model can provide a reference for identifying cases with high risk of early death among stage IV breast cancer patients and play an auxiliary role in guiding individual treatment. PMID: 32778637 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 13, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Fiber Type-Specific Morphological and Cellular Changes of Paraspinal Muscles in Patients with Severe Adolescent Idiopathic Scoliosis.
CONCLUSIONS The fiber type-specific pathological changes on the concave side seemed to be more severe. Some fiber type-specific characteristics (CSA, myonuclei density, total/activated SC density) were closely associated with curve severity. More attention should be paid to PSM physiotherapy treatment on the concave side. PMID: 32778639 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 13, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Silencing of Long Non-Coding RNA (LncRNA) Non-Coding RNA Activated by DNA Damage (NORAD) Inhibits Proliferation, Invasion, Migration, and Promotes Apoptosis of Glioma Cells via Downregulating the Expression of AKR1B1.
CONCLUSIONS These findings demonstrated that NORAD silencing suppressed proliferation, invasion, and migration and boosted apoptosis of glioma cells via downregulating the AKR1B1 expression, which may provide a potential therapeutic target for glioma treatment. PMID: 32778640 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 13, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Current Status of Research on the Role of Circular RNAs in Hepatocellular Carcinoma and Clinical Implications.
Authors: Zou RC, Li LL, Yuan HL Abstract The latest statistics show that rates of morbidity and mortality for hepatocellular carcinoma are gradually increasing over time. Accumulating evidence indicates that circular RNAs (circRNAs) participate in the regulation of gene transcription and translation and exert a crucial role in endogenous RNA network. circRNAs are implicated in the pathogenesis of numerous tumors including hepatocellular carcinoma (HCC), gastric carcinoma and bladder cancer. Of note, the effect of circRNAs in HCC has drawn increasing public attention. Previous studies revealed that the function of c...
Source: Medical Science Monitor - August 13, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Nkx2-5 Regulates the Proliferation and Migration of H9c2 Cells.
CONCLUSIONS Nkx2-5 may regulate proliferation and migration of the H9c2 cells through the genes Tgfb-2, Bmp10, Id2, Wt1, Hey1, and Cacna1g; rno-miR-1-3p; the TGF‑ß signaling pathway; the MAPK signaling pathway; as well as other genes and pathways. PMID: 32780729 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 13, 2020 Category: Research Tags: Med Sci Monit Source Type: research

A Regulatory Axis of circ_0008193/miR-1180-3p/TRIM62 Suppresses Proliferation, Migration, Invasion, and Warburg Effect in Lung Adenocarcinoma Cells Under Hypoxia.
CONCLUSIONS Upregulating circ_0008193 inhibited LUAD cell proliferation, migration, invasion, and Warburg effect under hypoxia in vitro and in vivo through regulation of the miR-1180-3p/TRIM62 axis. PMID: 32782238 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 13, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Retinoic Acid-Platinum (II) Complex [RT-Pt(II)] Protects Against Rheumatoid Arthritis in Mice via MEK/Nuclear Factor kappa B (NF- κB) Pathway Downregulation.
CONCLUSIONS In summary, the present study demonstrated that RT-Pt(II) inhibits TNF-alpha-induced inflammatory response, suppresses cell viability, and induces apoptosis in rheumatoid arthritis synovial cells. Moreover, RT-Pt(II) exhibited its effect through targeting the MEK/NF-kappaB pathway. Therefore, RT-Pt(II) can be used for the development of treatments for rheumatoid arthritis. PMID: 32741960 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 5, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Galectins for Diagnosis and Prognostic Assessment of Human Diseases: An Overview of Meta-Analyses.
Authors: Liu Y, Meng H, Xu S, Qi X Abstract An increasing number of studies have explored the activities and functions of galectins. However, translation of these researches into clinical practice seems to be lacking. As compared to scattered individual studies, meta-analyses can provide a more comprehensive review of current evidence and reach a more unbiased and powered conclusion by synthesizing data from diverse studies. In this paper, findings from meta-analyses were reviewed to establish the role of galectins in diagnosis and prognostic assessment of various human diseases. First, in patients with cancer, gal...
Source: Medical Science Monitor - August 5, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Effects of Contrast Therapy Using Infrared and Cryotherapy as Compared with Contrast Bath Therapy on Blood Flow, Muscle Tone, and Pain Threshold in Young Healthy Adults.
Authors: Kim J, Jung H, Yim J Abstract BACKGROUND The aim of this research was to compare the effects of contrast bath therapy (CBT) and contrast therapy (CT) using infrared (IR) and cryotherapy (CR) on blood flow, muscle tone, and pain in the forearm. MATERIAL AND METHODS Twenty healthy individuals participated in this study. Each participant received 2 kinds of CT separated by a week. CBT involved immersion in hot water (38-40°C) for 4 minutes, followed by 1 minute of immersion in cold water (12-14°C) for four rotations. CT using IR and CR was performed in the same manner as CBT. RESULTS The variables mea...
Source: Medical Science Monitor - August 5, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Sirtuin 3 mRNA Expression is Downregulated in the Brain Tissues of Alzheimer's Disease Patients: A Bioinformatic and Data Mining Approach.
CONCLUSIONS SIRT3 mRNA is downregulated in the brain tissues of AD patients, promoting the progression of AD. PMID: 32747616 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 5, 2020 Category: Research Tags: Med Sci Monit Source Type: research

TPX2 Promotes Metastasis and Serves as a Marker of Poor Prognosis in Non-Small Cell Lung Cancer.
CONCLUSIONS This study demonstrated that TPX2 promotes the metastasis and malignant progression of NSCLC and could thus serve as a marker of poor prognosis in NSCLC. PMID: 32748897 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 5, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Role and Mechanism of Maresin-1 in Acute Lung Injury Induced by Trauma-Hemorrhagic Shock.
CONCLUSIONS Our study showed that MaR1 could effectively alleviated THS-induced lung injury via inhibiting the excitation of the TLR4/p38MAPK/NF-kappaB pathway in THS-induced rats, suggesting that MaR1 might be a novel agent for lung damage treatment. PMID: 32750045 [PubMed - as supplied by publisher] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 5, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Prognostic Implications of Novel Gene Signatures in Gastric Cancer Microenvironment.
CONCLUSIONS In general, this study constructs a prognostic risk assessment model for gastric cancer, which could improve the prognosis stratification of patients combined with other clinical indicators. PMID: 32740646 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 4, 2020 Category: Research Tags: Med Sci Monit Source Type: research