Computer-Based 3D Simulations to Formulate Preoperative Planning of Bridge Crane Technique for Thoracic Ossification of the Ligamentum Flavum.
Authors: Yan C, Jia HC, Xu JX, Xu T, Chen K, Sun JC, Shi JG Abstract BACKGROUND The bridge crane technique is a novel surgical technique for the treatment of thoracic ossification of the ligamentum flavum (TOLF), but its preoperative planning has not been studied well, which limits the safety and efficacy of surgery to some extent. The purpose of this study was to investigate the method of application and effect of computer-aided preoperative planning (CAPP) on the bridge crane technique for TOLF. MATERIAL AND METHODS This retrospective multi-center included 40 patients with TOLF who underwent the bridge crane tech...
Source: Medical Science Monitor - December 19, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Presence of White Matter Lesions Associated with Diabetes-Associated Cognitive Decline in Male Rat Models of Pre-Type 2 Diabetes.
CONCLUSIONS WML is associated with DACD and appears before the onset of T2DM and signs of DACD and plays a role in diabetes-associated cognitive decline. Metformin reduces WMLs but does not rescue cognitive dysfunction. PMID: 31848329 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - December 19, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Systemic Immune-Inflammatory Index Predicts Clinical Outcomes for Elderly Patients with Acute Myocardial Infarction Receiving Percutaneous Coronary Intervention.
Authors: Huang J, Zhang Q, Wang R, Ji H, Chen Y, Quan X, Zhang C Abstract BACKGROUND We assessed the utility of the systemic immune-inflammatory index (SII) in estimating the in-hospital and long-term prognosis of elderly patients with acute myocardial infarction (AMI) who received percutaneous coronary intervention (PCI). MATERIAL AND METHODS Our study evaluated 711 consecutive elderly patients (age 65-85 years) from January 2015 to December 2017. The correlation between clinical outcomes and SII was analyzed through the stepwise Cox regression analysis and the Kaplan-Meier approach. The clinical endpoints were al...
Source: Medical Science Monitor - December 19, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Serum Uric Acid Shows Inverted "U" Type Correlation with Osteoporosis in Chinese Ankylosing Spondylitis Patients: A Retrospective Study.
This study was to investigate the correlation between osteoporosis and serum uric acid in ankylosing spondylitis (AS) patients, and to further identify potential factors that might be associated with osteoporosis in AS patients. MATERIAL AND METHODS We included 182 AS patients, consisted of 143 male patients and 39 female patients, who visited our hospital from January 1, 2014 to December 31, 2018. We used dual-energy x-ray absorptiometry to measure bone mineral density (BMD) of orthotopic lumbar vertebrae in patients with AS. The gender, age, disease duration, BMD, T-score, Z-score, uric acid, erythrocyte sedimentation ra...
Source: Medical Science Monitor - December 19, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Effect of Periodontitis and Toothbrushing Frequency on Obesity Onset: A Cohort Study.
Authors: Morita T, Yamazaki Y, Seto M, Yamamoto T, Nakai K, Tanaka H, Ozaki M, Koshi R, Maeno M, Kawato T Abstract BACKGROUND The interplay between obesity and periodontitis has been widely examined. While obesity was reported as a risk factor for periodontitis, the inverse relationship is still little explored. Therefore, we aimed to determine whether periodontitis and toothbrushing frequency affect the onset of obesity. MATERIAL AND METHODS This cohort study included 1619 employees of a business enterprise headquartered in Tokyo, who in 2002 and 2006 underwent in prescribed annual health checks, both general and ...
Source: Medical Science Monitor - December 19, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Identification of Key Genes in Thyroid Cancer Microenvironment.
CONCLUSIONS We identified 30 tumor microenvironment related genes in thyroid cancer. Among these hub genes, CXCL10 can be regarded as a prognostic biomarker in thyroid cancer. PMID: 31839674 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - December 18, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Long Noncoding RNA FTX Reduces Hypertrophy of Neonatal Mouse Cardiac Myocytes and Regulates the PTEN/PI3K/Akt Signaling Pathway by Sponging MicroRNA-22.
CONCLUSIONS The expression of lnc-FTX was associated with reduced hypertrophy of neonatal mouse cardiac myocytes and regulated the PTEN/PI3K/Akt signaling pathway by sponging miRNA-22. PMID: 31840653 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - December 18, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Long Noncoding RNA (lncRNA) FOXD2-AS1 Promotes Cell Proliferation and Metastasis in Hepatocellular Carcinoma by Regulating MiR-185/AKT Axis.
CONCLUSIONS LncRNA FOXD2-AS1 promoted hepatocellular carcinoma development by regulation miR-185/AKT axis. PMID: 31841454 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - December 18, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Role of LAMA4 Gene in Regulating Extravillous Trophoblasts in Pathogenesis of Preeclampsia.
CONCLUSIONS Downregulation of the LAMA4 gene inhibits the proliferation, migration, and invasion of EVT to suppress the expression of vascular factors, leading to the occurrence or development of preeclampsia. Our data provide new insights into modulation of LAMA4 expression as a potential target for therapy against preeclampsia. Further research is needed on placenta sampling from pre-eclamptic pregnancies to validate the effect of LAMA4 expression compared to control pregnancies. PMID: 31842202 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - December 18, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Bioinformatics Analysis of Gene Expression Profiles for Risk Prediction in Patients with Septic Shock.
This study aimed to undertake a bioinformatics analysis of gene expression profiles for risk prediction in septic shock. MATERIAL AND METHODS Two good quality datasets associated with septic shock were downloaded from the Gene Expression Omnibus (GEO) database, GSE64457 and GSE57065. Patients with septic shock had both sepsis and hypotension, and a normal control group was included. The differentially expressed genes (DEGs) were identified using OmicShare tools based on R. Functional enrichment of DEGs was analyzed using DAVID. The protein-protein interaction (PPI) network was established using STRING. Survival curves of k...
Source: Medical Science Monitor - December 17, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Different Patterns of Functional Connectivity Alterations Within the Default-Mode Network and Sensorimotor Network in Basal Ganglia and Pontine Stroke.
CONCLUSIONS The different patterns of FC damage in patients with basal ganglia stroke and patients with pontine stroke in the early chronic phase may provide a new method for investigating lesion-induced network plasticity. PMID: 31838483 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - December 17, 2019 Category: Research Tags: Med Sci Monit Source Type: research

A Positive Tetraspanin 8 (TSPAN8)/ β-Catenin Regulatory Loop Enhances the Stemness of Colorectal Cancer Cells.
CONCLUSIONS TSPAN8 promotes colorectal cancer stemness through a positive TSPAN8/ß-catenin regulatory loop. PMID: 31838484 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - December 17, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Impact of Cervical Sensory Feedback for Forward Head Posture on Headache Severity and Physiological Factors in Patients with Tension-type Headache: A Randomized, Single-Blind, Controlled Trial.
Authors: Lee E, Lee S Abstract BACKGROUND Tension-type headache (TTH) decreases the ability to concentrate and function during daily activities in affected patients. As most patients with TTH exhibit forward head posture (FHP). Various interventions have been proposed to resolve TTH. However, research regarding the efficacy of these interventions remains lacking. The present study aimed to investigate the association between FHP and TTH, and to evaluate the efficacy of various intervention methods on headache symptoms and other clinical variables in patients with TTH induced by FHP. MATERIAL AND METHODS Participant...
Source: Medical Science Monitor - December 17, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Salvianolic Acid C Attenuates LPS-Induced Inflammation and Apoptosis in Human Periodontal Ligament Stem Cells via Toll-Like Receptors 4 (TLR4)/Nuclear Factor kappa B (NF- κB) Pathway.
CONCLUSIONS Taken together, our results revealed that SAC effectively attenuates LPS-induced inflammation and apoptosis via the TLR4/NF-kappaB pathway and that SAC is effective in treating periodontitis. PMID: 31831723 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - December 15, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Itraconazole Alters the Stem Cell Characteristics of A549 and NCI-H460 Human Lung Cancer Cells by Suppressing Wnt Signaling.
CONCLUSIONS Itraconazole altered the stemness characteristics of A549 and NCI-H460 human lung cancer cells by suppressing Wnt signaling but did not affect cell viability. PMID: 31833479 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - December 15, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Serum Calprotectin Levels and Outcome Following Percutaneous Coronary Intervention in Patients with Diabetes and Acute Coronary Syndrome.
CONCLUSIONS In patients with diabetes and the co-morbidity of ACS, a high serum level of calprotectin was associated with a significantly increased risk for MACE following PCI. PMID: 31834876 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - December 15, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Effect of ANGPTL7 on Proliferation and Differentiation of MC3T3-E1 Cells.
CONCLUSIONS The results suggest that by regulating the expression of BMPs, ANGPTL7 directly promotes proliferation, differentiation, and mineralization of osteoblasts. PMID: 31835268 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - December 15, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Omega-3 Fatty Acid Supplementation Reduces Intervertebral Disc Degeneration.
CONCLUSIONS The results of this study suggest that n-3 FA dietary supplementation reduces systemic inflammation by lowering AA/EPA ratios in blood serum and has potential protective effects on the progression of spinal disc degeneration, as demonstrated by reduced needle injury-induced dehydration of intervertebral discs and reduced histological signs of IVD degeneration. PMID: 31836696 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - December 15, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Comparison of Prevalence and Ultrasonography Features of Thyroglossal Duct Cyst in Adults According to Radioactive Iodine Ablation.
CONCLUSIONS RIA may not be associated with the prevalence or enlargement of TGDCs. PMID: 31837133 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - December 15, 2019 Category: Research Tags: Med Sci Monit Source Type: research

The Effects of Orientin on Proliferation and Apoptosis of T24 Human Bladder Carcinoma Cells Occurs Through the Inhibition of Nuclear Factor-kappaB and the Hedgehog Signaling Pathway.
CONCLUSIONS Treatment of T24 human bladder carcinoma cells in vitro with orientin inhibited cell proliferation and promoted cell apoptosis by suppressing the Hedgehog signaling pathway and NF-kappaB. PMID: 31837261 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - December 15, 2019 Category: Research Tags: Med Sci Monit Source Type: research

A New Approach to Transcranial Direct Current Stimulation in Improving Cognitive Motor Learning and Hand Function with the Nintendo Switch in Stroke Survivors.
This study focused on cognitive motor learning in relation to hand function of stroke survivors. MATERIAL AND METHODS We enrolled 30 subjects with cognitive and hand function disorders. The participants in each group were inpatients at a hospital in Korea and had undergone neurorehabilitation training (60 min). Groups 1 and 3 had tDCS applied for 20 min, while group 2 received sham tDCS for the same duration. Afterwards, groups 1 and 2 played Nintendo games for 20 min, but group 3 did not. The total intervention period was 40 min/day, 2 days/week, for 8 weeks. The cognitive and hand function of the subjects were assessed u...
Source: Medical Science Monitor - December 15, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Transmembrane and Ubiquitin-Like Domain Containing 1 Protein (TMUB1) Negatively Regulates Hepatocellular Carcinoma Proliferation via Regulating Signal Transducer and Activator of Transcription 1 (STAT1).
CONCLUSIONS TMUB1 negatively regulates hepatocellular carcinoma proliferation via regulating STAT1. PMID: 31827061 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - December 14, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Efficacy of Vertebroplasty in Short-Segment Pedicle Screw Fixation of Thoracolumbar Fractures: A Meta-Analysis.
Authors: Zhang GA, Zhang WP, Chen YC, Hou Y, Qu W, Ding LX Abstract BACKGROUND Short-segment pedicle screw instrumentation provides superior outcomes in treating thoracolumbar fractures. Nevertheless, the effect of intermediate screws on the outcome of short-segment instrumentation at the fracture level has not been specifically analyzed. We performed an update meta-analysis of the effect of additional vertebroplasty on the outcome of short-segment instrumentation to determine the role of screws for patients with fractured vertebra. MATERIAL AND METHODS A systematic literature search was conducted, updated to Janua...
Source: Medical Science Monitor - December 14, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Sensitivity of Reality Monitoring to Fluency: Evidence from Behavioral Performance and Event-Related Potential (ERP) Old/New Effects.
CONCLUSIONS As results revealed, the factor of fluency does influence reality monitoring in terms of accuracy and responding speed. Meanwhile, for imagined items of low fluency, the absence of FN400 and frontal old/new effect also suggests the sensitivity of reality monitoring to fluency, because these representatives of familiarity-based processing and post-retrieval monitoring are inevitably involved in the process of differentiating internal source from external source. PMID: 31830005 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - December 14, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Validity and Reliability of the International Physical Activity Questionnaire in Chinese Hemodialysis Patients: A Multicenter Study in China.
This study aimed to assess the reliability and validity of the International Physical Activity Questionnaire (IPAQ) in Chinese maintenance hemodialysis (MHD) patients. These findings could help increase the validity of future MHD physical activity (PA) studies, both within China and throughout the world. MATERIAL AND METHODS A multicenter prospective cohort study including 320 patients was conducted in Zhejiang, China. Patients' PA was assessed by analyzing answers to the International Physical Activity Questionnaire Chinese version (IPAQ-C) during hemodialysis, and comparing the results with 1 week of pedometer data. RESU...
Source: Medical Science Monitor - December 12, 2019 Category: Research Tags: Med Sci Monit Source Type: research

A Predictive Model to Distinguish Papillary Thyroid Carcinomas from Benign Thyroid Nodules Using Ultrasonographic Features: A Single-Center, Retrospective Analysis.
CONCLUSIONS This predictive model is a reliable, simple, and cost-effective diagnostic tool for PTC. PMID: 31820741 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - December 12, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Analysis of Homogeneous and Heterogeneous Factors for Bone Metastasis in Esophageal Cancer.
CONCLUSIONS The prevalence of initial bone metastasis was approximately 8.0% in esophageal cancer patients. More attention should be paid to patients with revealed risk and prognostic factors because these factors can guide individualize bone metastasis screening and treatment of esophageal cancer patients. PMID: 31821313 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - December 12, 2019 Category: Research Tags: Med Sci Monit Source Type: research

The Na+/K+ ATPase Inhibitor Ouabain Attenuates Stemness and Chemoresistance of Osteosarcoma Cells.
CONCLUSIONS This work provides a potential compound for treating OS patients, especially OS patients with chemoresistance. PMID: 31822650 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - December 12, 2019 Category: Research Tags: Med Sci Monit Source Type: research

The Prognostic Value of m6A RNA Methylation Regulators in Colon Adenocarcinoma.
Authors: Liu T, Li C, Jin L, Li C, Wang L Abstract BACKGROUND The RNA-seq FPKM data of 331 colorectal adenocarcinoma samples in The Cancer Genome Atlas database with matching clinical data were analyzed in order to reveal the prognostic value of m6A RNA methylation regulators in colon adenocarcinoma. MATERIAL AND METHODS The expression of 13 m6A RNA methylated regulators in samples were analyzed. The samples were classified into Cluster I and II by consistent clustering. The gene distribution was analyzed by principal component analysis. Further functional analysis of selected m6A RNA genes was performed and potent...
Source: Medical Science Monitor - December 12, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Shixiang Plaster, a Traditional Chinese Medicine, Promotes Healing in a Rat Model of Diabetic Ulcer Through the receptor for Advanced Glycation End Products (RAGE)/Nuclear Factor kappa B (NF- κB) and Vascular Endothelial Growth Factor (VEGF)/Vascular Cell Adhesion Molecule-1 (VCAM-1)/Endothelial Nitric Oxide Synthase (eNOS) Signaling Pathways.
This study aimed to investigate the effects of shixiang plaster and aminoguanidine on wound healing in the streptozotocin-induced rat model of diabetes and the molecular mechanisms involved. MATERIAL AND METHODS Sprague-Dawley rats treated with intraperitoneal streptozotocin and given surgical wounds were divided into the untreated chronic ulcer group (n=10), the aminoguanidine group (n=10), the shixiang plaster group (n=10), and the control group with sham surgery (n=10). Granulation tissue samples underwent light microscopy to evaluate angiogenesis and immunohistochemistry to identify AGE, vascular endothelial growth fac...
Source: Medical Science Monitor - December 12, 2019 Category: Research Tags: Med Sci Monit Source Type: research

The Role of Serine Peptidase Inhibitor Kazal Type 13 (SPINK13) as a Clinicopathological and Prognostic Biomarker in Patients with Clear Cell Renal Cell Carcinoma.
This study aimed to investigate mRNA expression of SPINK13 in clear cell renal cell carcinoma (CCRCC) in human tissue and to use bioinformatics data to investigate the role of SPINK13 expression as a clinicopathological and prognostic biomarker for patients with CCRCC. MATERIAL AND METHODS Patients with CCRCC (N=533) with available RNA sequence data from The Cancer Genome Atlas (TCGA)-CCRCC database were analyzed with patients who had a tissue diagnosis of CCRCC (N=305) at the Fudan University Shanghai Cancer Center (FUSCC). Differential transcriptional and proteome expression profiles were obtained from the ONCOMINE cance...
Source: Medical Science Monitor - December 12, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Farnesoid X Receptor (FXR) Aggravates Amyloid- β-Triggered Apoptosis by Modulating the cAMP-Response Element-Binding Protein (CREB)/Brain-Derived Neurotrophic Factor (BDNF) Pathway In Vitro.
CONCLUSIONS These data suggest that FXR regulates Aß-induced neuronal apoptosis, which may be dependent on the CREB/BDNF signaling pathway in vitro. PMID: 31812977 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - December 11, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Spleen Tyrosine Kinase (SYK) in the Progression of Peritoneal Fibrosis Through Activation of the TGF- β1/Smad3 Signaling Pathway.
CONCLUSIONS In a rat model and in rat PMCs, expression of SYK increased peritoneal fibrosis through activation of the TGF-ß1/Smad3 signaling pathway. PMID: 31812978 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - December 11, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Investigation of Electromyographic Activity of Pelvic Floor Muscles in Different Body Positions to Prevent Urinary Incontinence.
This study aimed to determine whether trunk stability muscles co-contract with body position as a factor of pelvic floor muscle (PFM) activity. MATERIAL AND METHODS Sixty-one healthy adults without pelvic floor dysfunction were examined for pelvic floor and trunk stability muscle activity in 4 body positions (ankle dorsiflexion and plantar flexion in standing position, and ankle dorsiflexion and plantar flexion in long sitting position). The activities of the PFMs via anal/vaginal probes, internal oblique (IO), multifidus (MF), tibialis anterior, and gastrocnemius muscles were measured by surface electromyography. Three-di...
Source: Medical Science Monitor - December 11, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Anti-Phospholipase A2 Receptor (Anti-PLA2R) Antibody in Diagnosis and Treatment of Idiopathic Membranous Nephropathy: A Single-Center Observational Study in China.
CONCLUSIONS Serum anti-PLA2R antibody, as determined by non-invasive technique, is a specific biomarker for diagnosis of IMN. Our results suggest that serum anti-PLA2R antibody has great potential to guide clinical diagnosis and treatment, as well as prognosis determination, in IMN patients. PMID: 31813930 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - December 11, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Establishment of a Multiplex Real-Time TaqMan-MGB Polymerase Chain Reaction (PCR) Method for the Simultaneous Detection of Three Animal Chlamydia Species.
CONCLUSIONS The novel established method in this study was able to detect 3 types of Chlamydia species simultaneously, and had high sensitivity, strong specificity, and good stability. It provided a rapid, reliable, and convenient method for epidemiological and clinical diagnosis of chlamydiosis in animals. PMID: 31814605 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - December 11, 2019 Category: Research Tags: Med Sci Monit Source Type: research

A Rat Model of Maternal Polycystic Ovary Syndrome Shows that Exposure to Androgens In Utero Results in Dysbiosis of the Intestinal Microbiota and Metabolic Disorders of the Newborn Rat.
CONCLUSIONS In a rat model of maternal PCOS, exposure to androgens in utero resulted in dysbiosis of the intestinal microbiota and metabolic disorders of the newborn female rats. PMID: 31815927 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - December 11, 2019 Category: Research Tags: Med Sci Monit Source Type: research

The Construction of a Radiation-Induced Brain Injury Model and Preliminary Study on the Effect of Human Recombinant Endostatin in Treating Radiation-Induced Brain Injury.
CONCLUSIONS Radiation can induce vasogenic edema and is associated with the RBI occurrence and development. VEGF protein is highly relevant to the induction of edema and thrombosis in the acute phase of RBI and in the early delayed phase of RBI, including vascular repair and regeneration, thrombus ablation and other events. Human recombinant endostatin can reduce the progression of cerebral edema during the early onset of RBI. PMID: 31816619 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - December 11, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Protective Effect of β-Glucogallin on Damaged Cataract Against Methylglyoxal Induced Oxidative Stress in Cultured Lens Epithelial Cells.
Protective Effect of β-Glucogallin on Damaged Cataract Against Methylglyoxal Induced Oxidative Stress in Cultured Lens Epithelial Cells. Med Sci Monit. 2019 Dec 07;25:9310-9318 Authors: Ma Y, Liu F, Xu Y Abstract BACKGROUND ß-glucogallin (GG) is one of the major plant polyphenolic antioxidants that have been associated with positive effects on human health and are crucial in the developing defense mechanism against the risk of diseases. However, reports on the protective mechanism of GG in lens epithelial cells are limited. MATERIAL AND METHODS ARPE-19 cells (a human retinal epithelial cell ...
Source: Medical Science Monitor - December 9, 2019 Category: Research Tags: Med Sci Monit Source Type: research

An Efficient Schistosoma japonicum Bivalent Membrane Protein Antigen DNA Vaccine Against Schistosomiasis in Mice.
CONCLUSIONS The double-membrane antigen DNA vaccine SjTsp2-29 elicited protection against Schistosoma infection and might serve as a vaccine candidate. PMID: 31811711 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - December 9, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Comparison of Methods of Endotamponade Used During 23-Gauge Pars Plana Vitrectomy and the Risk of Raised Intraocular Pressure During 24-Month Follow-Up: A Retrospective Study of 196 Patients.
CONCLUSIONS Silicone oil endotamponade in PPV was associated with an increased risk of IOP at 24-month follow-up. PMID: 31811816 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - December 9, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Resveratrol Protects the Myocardium in Sepsis by Activating the Phosphatidylinositol 3-Kinases (PI3K)/AKT/Mammalian Target of Rapamycin (mTOR) Pathway and Inhibiting the Nuclear Factor- κB (NF-κB) Signaling Pathway.
Resveratrol Protects the Myocardium in Sepsis by Activating the Phosphatidylinositol 3-Kinases (PI3K)/AKT/Mammalian Target of Rapamycin (mTOR) Pathway and Inhibiting the Nuclear Factor-κB (NF-κB) Signaling Pathway. Med Sci Monit. 2019 Dec 06;25:9290-9298 Authors: Shang X, Lin K, Yu R, Zhu P, Zhang Y, Wang L, Xu J, Chen K Abstract BACKGROUND Sepsis combined with myocardial injury is an important cause of septic shock and multiple organ failure. However, the molecular mechanism of sepsis-induced myocardial dysfunction has not yet been thoroughly studied. Resveratrol has been an important rese...
Source: Medical Science Monitor - December 8, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Size-Specific Dose Estimates Based on Water-Equivalent Diameter and Effective Diameter in Computed Tomography Coronary Angiography.
Authors: Xu J, Wang X, Xiao H, Xu J Abstract BACKGROUND To determine the difference in size-specific dose estimates (SSDEs), separately based on effective diameter (deff) and water equivalent diameter (dw) of the central slice of the scan range in computed tomography coronary angiography (CTCA). MATERIAL AND METHODS There were 134 patients who underwent CTCA examination, were electronically retrieved. SSDEs (SSDEdeff and SSDEdw) were calculated using 2 approaches: deff and dw. The median SSDEs and mean absolute relative difference of SSDEs were calculated. Linear regression model was used to assess the absolute rel...
Source: Medical Science Monitor - December 8, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Behaviorally-Mediated Entrainment of Whole-Body Metabolic Processes: Conservation and Evolutionary Development of Mitochondrial Respiratory Complexes.
Authors: Stefano GB, Esch T, Kream RM Abstract The relaxation response derives its health benefits by reestablishing "normal" equilibria between the sympathetic and parasympathetic branches of the autonomic nervous system. Recent work suggests that this behavioral training provides positive effects on mitochondrial bioenergetics, insulin secretion, and reductions in pro-inflammatory and stress-related pathways. We have previously contended, however, that correlative associations of relaxation training with positive changes in gene expression in selected biological systems are strongly suggestive of adapti...
Source: Medical Science Monitor - December 8, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Orai1 Promotes Osteosarcoma Metastasis by Activating the Ras-Rac1-WAVE2 Signaling Pathway.
Authors: Guo Y, Zhu J, Wang X, Li R, Jiang K, Chen S, Fan J, Xue L, Hao D Abstract BACKGROUND The purpose of this study was to investigate whether Orai1 plays a role in the metastasis of osteosarcoma. MATERIAL AND METHODS The expression of Orai1 was silenced by small interfering RNAs against Orai1 (Orai1 siRNA) in osteosarcoma MG-63 cells. Various experiments were carried out to detect the changes in migration, invasion, and adhesion ability of these osteosarcoma cells. Furthermore, the activity of Rac1, Wave2, and Ras was detected using Western blot analysis. Moreover, the Rac1 and Ras inhibitors were used to conf...
Source: Medical Science Monitor - December 7, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Differently Expressed Genes (DEGs) Relevant to Type 2 Diabetes Mellitus Identification and Pathway Analysis via Integrated Bioinformatics Analysis.
CONCLUSIONS DEGs of T2DM may play an essential role in disease development and may be potential pathogeneses of T2DM. PMID: 31797865 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - December 7, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Phylogenetic and Epidemiological Analysis of Measles Viruses in Shenzhen, China from January 2015 to July 2019.
CONCLUSIONS Our results showed there was a seasonal measles outbreak in Shenzhen Children's Hospital. All the measles virus from 129 measles patients were H1 viruses. The clinical signs also showed a difference between unvaccinated and vaccinated patients. Moreover, most of the unvaccinated patients came from migrant worker families. We suggest there is a need for increased health promotion and vaccination programs for migrant workers and people living in remote villages. PMID: 31800568 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - December 7, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Bioinformatics Analysis of Key Genes and Pathways Associated with Thrombosis in Essential Thrombocythemia.
CONCLUSIONS Bioinformatics analysis identified DEGs and hub genes that interacted with CD34+ cells and neutrophils that may predict an increased risk of thrombosis in patients with ET. These preliminary findings should be validated using next-generation sequencing (NGS) and clinical studies. PMID: 31801935 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - December 7, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Quantitative and Qualitative Evaluation of Breast Cancer Prognosis: A Sonographic Elastography Study.
CONCLUSIONS Elastography is a useful imaging technique in differentiating benign breast masses from malignant ones. The strong relationship between prognostic factors and elastographic measures also demonstrated its excellent performance in predicting the prognosis of breast malignancies. PMID: 31802780 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - December 7, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Identification and Integrated Analysis of Key Biomarkers for Diagnosis and Prognosis of Non-Small Cell Lung Cancer.
Authors: Liu X, Liu X, Li J, Ren F Abstract Non-small cell lung cancer (NSCLC) is the main histologic form of lung cancer that affects human health, but biomarkers for therapeutic diagnosis and prognosis of the disease are currently lacking. The gene expression profile GSE18842 was downloaded from the Gene Expression Omnibus database in this prospective study, which consisted of 46 tumors and 45 controls. After screening differentially expressed genes (DEGs), we conducted functional enrichment analysis and KEGG analysis with upregulated differentially expressed genes (uDEGs) and downregulated differentially express...
Source: Medical Science Monitor - December 7, 2019 Category: Research Tags: Med Sci Monit Source Type: research