Role of Maternal Nutrition in the Health Outcomes of Mothers and Their Children: A Retrospective Analysis.
In this study, pregnancy medical records of women were analyzed. Data related to questionnaires which had been provided during hospital stays for nutritional consumption were gathered. Demographic characteristics and health outcomes of mothers and their children were recorded. Correlations of health outcomes with maternal nutrition were tested with respect to Z-scores at 95% confidence level. RESULTS Based on the health outcomes of mothers and their children, the study divided participants into 2 groups. The first group was mothers and their children with good health outcomes (live births with weighing ≥2.5 kg; the GHO ...
Source: Medical Science Monitor - June 16, 2019 Category: Research Tags: Med Sci Monit Source Type: research

A Computed Tomography Study of the Association Between Increased Patellar Tilt Angle and Femoral Anteversion in 30 Patients with Recurrent Patellar Dislocation.
CONCLUSIONS A significantly higher FA and PTA were found in patients with RPD compared with controls. An increased PTA and a FA ≥25° were significantly associated with RPD. A derotational femoral osteotomy may be indicated to correct patellar tilt in patients with RPD when femoral anteversion is ≥25°. PMID: 31186399 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - June 14, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Efficacy and Safety of In Vitro Fertilization (IVF)/Intracytoplasmic Sperm Injection (ICSI) Among Patients with Endometriosis After a Shortened Protocol of Long-Term Pituitary Downregulation.
CONCLUSIONS This study showed that the shortened regimen and the ultralong regimen did not produce different pregnancy outcomes after ART, and the single-application, long-term GnRH-a protocol may serve as a cost-effective and safe treatment protocol for EMs patients. PMID: 31187785 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - June 14, 2019 Category: Research Tags: Med Sci Monit Source Type: research

One-Year Results Evaluating the Effects of Concentrated Growth Factors on the Healing of Intrabony Defects Treated with or without Bone Substitute in Chronic Periodontitis.
CONCLUSIONS CGF reduced periodontal intrabony defects depth and, when mixed with Bio-Oss, CGF showed better results in the early period and the effect was more stable. PMID: 31188801 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - June 14, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Nutrition, Physical Exercise, and the Prevalence of Sarcopenia in Elderly Residents in Nursing Homes in China.
CONCLUSIONS The prevalence of sarcopenia in elderly residents in three nursing homes in Suzhou City was 28.8%. Increasing age was a risk factor for sarcopenia. Increased BMI and a diet containing meat, eggs, and milk were protective factors. The findings from this study provide support that adequate dietary protein can prevent sarcopenia in the elderly. PMID: 31189870 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - June 14, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Identification of a 5-Gene Signature Predicting Progression and Prognosis of Clear Cell Renal Cell Carcinoma.
CONCLUSIONS We identified differentially expressed genes that may be involved in the metastasis of ccRCC. Moreover, a predictive signature based on the expression of OTX1, MATN4, PI3, ERVV-2, and NFE4 could be an independent prognostic factor for ccRCC. PMID: 31194719 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - June 14, 2019 Category: Research Tags: Med Sci Monit Source Type: research

A Retrospective Propensity Score Matched Study of the Preoperative C-Reactive Protein to Albumin Ratio and Prognosis in Patients with Resectable Non-Metastatic Breast Cancer.
Authors: Zhou L, Ma S, Balde AI, Han S, Cai Z, Li Z Abstract BACKGROUND A retrospective study aimed to investigate the association between the CRP to albumin ratio and prognosis in patients with resectable non-metastatic breast cancer in terms of disease-free survival (DFS) and overall survival (OS) using propensity score matching. MATERIAL AND METHODS Patients with newly diagnosed resectable non-metastatic breast cancer (n=200) who underwent modified radical mastectomy between January 2008 to June 2013 included a group with an increased CRP to albumin ratio ≥0.029 (n=80) and a group with reduced CRP to albumin ratio
Source: Medical Science Monitor - June 13, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Association of Key Genes and Pathways with Atopic Dermatitis by Bioinformatics Analysis.
CONCLUSIONS The associated pathways and genes not only help us understand the molecular mechanism of the disease, but also provide research directions or targets for accurate diagnosis and treatment. PMID: 31184315 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - June 13, 2019 Category: Research Tags: Med Sci Monit Source Type: research

miR-30c-5p Reduces Renal Ischemia-Reperfusion Involving Macrophage.
CONCLUSIONS We preliminarily demonstrated that miR-30c-5p agomir might decrease renal I/R through transformation of M1 macrophages to M2 macrophages and resulted in changes in inflammatory cytokines. PMID: 31185006 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - June 13, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Monocarboxylate Transporter 4 (MCT4) Overexpression Is Correlated with Poor Prognosis of Osteosarcoma.
This study aimed to determine the expression level of MCT4 protein and its prognostic value in osteosarcoma. MATERIAL AND METHODS MCT4 expression was detected via immunohistochemical and Western blot analysis for 100 osteosarcoma patients. The correlation between MCT4 expression and clinical factors among the patients was analyzed using the chi-square test. Overall survival of osteosarcoma patients was estimated by Kaplan-Meier analysis. The prognostic value of MCT4 was evaluated using Cox regression analysis with adjustments for clinicopathological variables. RESULTS MCT4 expression was significantly upregulated in osteos...
Source: Medical Science Monitor - June 11, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Weighted Gene Coexpression Network Analysis Identifies Key Genes and Pathways Associated with Idiopathic Pulmonary Fibrosis.
CONCLUSIONS WGCNA was used to identify functional modules and hub genes involved in the pathogenesis of IPF. PMID: 31177264 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - June 11, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Identification of Key Genes and Pathway for Ovarian Neoplasms Using the OVDM1 Cell Line Based on Bioinformatics Analysis.
CONCLUSIONS The present study could deepen the understanding of the molecular mechanism of ovarian neoplasms using the OVDM1 cell line, which could be useful in developing clinical treatments of ovarian neoplasms. PMID: 31177266 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - June 11, 2019 Category: Research Tags: Med Sci Monit Source Type: research

microRNA-378a Regulates the Reactive Oxygen Species (ROS)/Phosphatidylinositol 3-Kinases (PI3K)/AKT Signaling Pathway in Human Lens Epithelial Cells and Cataract.
CONCLUSIONS In HLECs, expression of miR-378a regulated ROS and PI3K/AKT signaling, and miR-378a was upregulated, and SOD1 was down-regulated in human cataract tissue. PMID: 31178586 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - June 11, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Regulatory Role of lncRNA NONHSAT089447 in the Dopamine Signaling Pathway in Schizophrenic Patients.
CONCLUSIONS Our results revealed that the lncRNA NONHSAT089447 participated in the dopamine signaling pathway via upregulation of DRDs. PMID: 31180069 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - June 11, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Differentially Expressed Gene Screening, Biological Function Enrichment, and Correlation with Prognosis in Non-Small Cell Lung Cancer.
CONCLUSIONS Differentially expressed genes are common in NSCLC patients and can be used as biomarkers for patient prognosis. PMID: 31181055 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - June 11, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Knockdown of Hypoxia-Inducible Factor 1 α (HIF-1α) Promotes Autophagy and Inhibits Phosphatidylinositol 3-Kinase (PI3K)/AKT/Mammalian Target of Rapamycin (mTOR) Signaling Pathway in Ovarian Cancer Cells.
CONCLUSIONS These findings show that knockdown of HIF-1alpha promoted autophagy and inhibited the PI3K/AKT/mTOR signaling pathway in ovarian cancer cells. PMID: 31175269 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - June 10, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Overexpression of Family with Sequence Similarity 83, Member A (FAM83A) Predicts Poor Clinical Outcomes in Lung Adenocarcinoma.
Authors: Zhang JT, Lin YC, Xiao BF, Yu BT Abstract BACKGROUND The aim of this study was to explore the expression levels of family with sequence similarity 83, member A (FAM83A) in lung adenocarcinoma (LUAD) and investigate its clinical prognostic value. MATERIAL AND METHODS Bioinformatics mining methods were used to predict the differential expression levels of FAM83A mRNA in LUAD and normal lung tissues based on the TCGA and Oncomine databases. Immunohistochemical staining was performed to demonstrate the FAM83A protein expression levels in 83 cases of LUAD combined with paired normal lung tissues. The correlatio...
Source: Medical Science Monitor - June 10, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Pharmacological Targets and the Biological Mechanisms of Formononetin for Alzheimer's Disease: A Network Analysis.
CONCLUSIONS Pharmacological network analysis was used to identify the gene targets and mechanisms of formononetin treatment in patients with AD. PMID: 31175839 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - June 10, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Perinatal Outcomes After Emergency Cervical Cerclage for Cervical Insufficiency with Prolapsed Membranes.
CONCLUSIONS ECC has good perinatal results. Our results provide clinical evidence for the efficacy and risks of ECC. PMID: 31168048 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - June 8, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Overexpression of the Ubiquitin-Specific Peptidase 9 X-Linked (USP9X) Gene is Associated with Upregulation of Cyclin D1 (CCND1) and Downregulation of Cyclin-Dependent Inhibitor Kinase 1A (CDKN1A) in Breast Cancer Tissue and Cell Lines.
This study aimed to investigate the role of USP9X in breast cancer tissue and cell lines. MATERIAL AND METHODS Immunohistochemistry was used to examine the expression levels of USP9X in 102 breast cancer tissue samples and 41 normal breast tissue samples. Overexpression of USP9X in MCF-7 and MDA-MB-231 breast cancer cell lines were studied by USP9X lentivirus vector transfection. Clustered regularly interspaced short palindromic repeats (CRISPR)/caspase-9 USP9X gene knockout was performed. Cell proliferation, growth, and survival were examined using the cell counting kit-8 (CCK-8) assay, the colony formation assay, flow cy...
Source: Medical Science Monitor - June 8, 2019 Category: Research Tags: Med Sci Monit Source Type: research

A Study of Diet and Lifestyle and the Risk of Urolithiasis in 1,519 Patients in Southern China.
CONCLUSIONS High consumptions of pickled foods and animal protein were the main risk factors for the development of urolithiasis in a population of southern China, but high fluid intake with a preference for strong tea, a diet of vegetables, and physical exercise were protective factors. PMID: 31170122 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - June 8, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Efficacy and Safety of "On-Demand" Dapoxetine in Treatment of Patients with Premature Ejaculation: A Meta-Analysis.
CONCLUSIONS "On-demand" dapoxetine is effective and safe for patients with PE, and a dose of 60 mg may be more effective than 30 mg. PMID: 31171764 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - June 8, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Efficacy and Prognosis of 3D Printing Technology in Treatment of High-Energy Trans-Syndesmotic Ankle Fracture Dislocation - "Log-Splitter" Injury.
This study aimed to retrospectively assess the feasibility and efficacy of three-dimensional (3D) printing technology in the treatment of high-energy trans-syndesmotic ankle fracture dislocation - "log-splitter" injury - and to evaluate the efficacy and prognosis. MATERIAL AND METHODS We included 29 patients (17 males and 12 females; mean age, 44.0±13.2 years) with log-splitter injury from June 2011 to December 2016, divided into a routine group (n=13) and a 3D printing group (n=16) according to the surgical method used. Operation time, intraoperative blood loss, fluoroscopy times, fracture union time, fun...
Source: Medical Science Monitor - June 8, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Overexpression of Long Noncoding RNAs (lncRNA) NF- κβ-Interacting Long Noncoding RNA (NKILA) in Ankylosing Spondylitis is Correlated with Transforming Growth Factor β1 (TGF-β1), Active Disease and Predicts Length of Treatment.
CONCLUSIONS Overexpression of lncRNA NKILA in ankylosing spondylitis is correlated with active disease and predicts length of treatment. LncRNA NKILA may participate in ankylosing spondylitis through the interaction with TGF-ß1, which is a key player in this disease. PMID: 31173579 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - June 8, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Calcium-Activated Chloride Channel A4 (CLCA4) Plays Inhibitory Roles in Invasion and Migration Through Suppressing Epithelial-Mesenchymal Transition via PI3K/AKT Signaling in Colorectal Cancer.
CONCLUSIONS CLCA4 inhibits migration and invasion by suppressing EMT via PI3K/ATK signaling and predicts favorable prognosis of CRC which may help to distinguish potential risk of lymph node metastasis in CRC. PMID: 31164625 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - June 7, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Virtual Reality Rehabilitation Versus Conventional Physical Therapy for Improving Balance and Gait in Parkinson's Disease Patients: A Randomized Controlled Trial.
Authors: Feng H, Li C, Liu J, Wang L, Ma J, Li G, Gan L, Shang X, Wu Z Abstract BACKGROUND The aim of this study was to investigate the effect of virtual reality (VR) technology on balance and gait in patients with Parkinson's disease (PD). MATERIAL AND METHODS The study design was a single-blinded, randomized, controlled study. Twenty-eight patients with PD were randomly divided into the experimental group (n=14) and the control group (n=14). The experimental group received VR training, and the control group received conventional physical therapy. Patients performed 45 minutes per session, 5 days a week, for 12 we...
Source: Medical Science Monitor - June 7, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Independent Clinical Factors Relevant to Prognosis of Patients with Idiopathic Pulmonary Fibrosis.
CONCLUSIONS Spirometry, GAP model, and BAL are helpful to forecast the prognosis of IPF. IPF patients also suffering from pulmonary arterial hypertension, hypoxemia, and hydropower disorder have a poor prognosis. PMID: 31166938 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - June 7, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Role of Phosphorylated AMP-Activated Protein Kinase (AMPK) in Myocardial Insulin Resistance After Myocardial Ischemia-Reperfusion During Cardiopulmonary Bypass Surgery in Dogs.
CONCLUSIONS The inability of GLUT-4 expression induced by the decreases in p-AMPK protein expression that may be one of the reasons for myocardial insulin resistance. PMID: 31160548 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - June 6, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Loganin Attenuates Osteoarthritis in Rats by Inhibiting IL-1 β-Induced Catabolism and Apoptosis in Chondrocytes Via Regulation of Phosphatidylinositol 3-Kinases (PI3K)/Akt.
CONCLUSIONS This work revealed that loganin treatment attenuated IL-1ß-treated apoptosis and ECM catabolism in rat chondrocytes via regulation of the PI3K/Akt signaling, revealing that loganin is a potentially useful treatment for OA. PMID: 31162482 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - June 6, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Biomechanical Effect of Different Graft Heights on Adjacent Segment and Graft Segment Following C4/C5 Anterior Cervical Discectomy and Fusion: A Finite Element Analysis.
CONCLUSIONS The graft height makes an important difference on the stress on the adjacent segment and the graft segment after anterior cervical discectomy and fusion. A 150% graft height was considered the proper graft height in C4/C5 ACDF, with the lowest stress on the adjacent segment and the graft segment. PMID: 31163019 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - June 6, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Cognitive Decline in Asymptomatic Middle Cerebral Artery Stenosis Patients with Moderate and Poor Collaterals: A 2-Year Follow-Up Study.
CONCLUSIONS MCAS patients with moderate and poor collateral circulation have impairment of ≥1 cognitive domain over time. The affected domains are consistent with the profile of vascular cognitive impairment. Good collateral circulation is more important in patients with MCAS, and is associated with less risk of cognitive disorders. PMID: 31148547 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - June 4, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Spatial and Translational Regulation of Exocyst Subunits by Cell Cycle in Budding Yeast.
CONCLUSIONS Cdk1 activity is required for exocyst polarization before cytokinesis during the cell cycle progression, but not for its assembly and localization on the plasma membrane. Dynamic localization and protein level of the complex subunits are regulated by the cell cycle. PMID: 31150370 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - June 4, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Celastrol Enhances the Anti-Liver Cancer Activity of Sorafenib.
CONCLUSIONS Celastrol enhances the antitumor activity of sorafenib in HCC tumor cells by suppressing the AKT pathway and VEGF autocrine system. PMID: 31152143 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - June 4, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Accuracy of C-Reactive Protein Test for Neonatal Septicemia: A Diagnostic Meta-Analysis.
CONCLUSIONS The area under the curve (AUC), negative LR, positive LR, Q* index, specificity, and dOR of the CRP test suggest that it is appropriate for detecting neonatal septicemia. PMID: 31152537 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - June 4, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Acupuncture Administration Improves Cognitive Functions and Alleviates Inflammation and Nuclear Damage by Regulating Phosphatidylinositol 3 Kinase (PI3K)/Phosphoinositol-Dependent Kinase 1 (PDK1)/Novel Protein Kinase C (nPKC)/Rac 1 Signaling Pathway in Senescence-Accelerated Prone 8 (SAM-P8) Mice.
This study aimed to investigate effects of acupuncture administration on cognitive function and associated mechanisms. MATERIAL AND METHODS Senescence-accelerated prone 8 (SAM-P8) mice were randomly divided into 3 groups: the SAM-P8 group (P8-CN), the SAM-P8 administrating with acupuncture (P8-Acup) group, and the SAM-P8 administrating without acupuncture (P8-Sham) group. Morris water maze test was conducted to evaluate cognitive functions (memory and learning ability). PDK1, nPKC, and Rac1 inhibitors were used to treat SAM-P8 mice. Transmission electron microscope analysis was used to examine nuclear damage hippocampal ti...
Source: Medical Science Monitor - June 4, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Lessons Learned from a Study of the Integration of a Point-of-Care Ultrasound Course into the Undergraduate Medical School Curriculum.
This study aimed to assess the effectiveness of a one-day POCUS course in a group of final-year medical students by pre-course and post-course assessment of both diagnostic ability and changes in student confidence levels in making a diagnosis. MATERIAL AND METHODS A prospective study recruited 57 final-year medical students who participated in a one-day POCUS course. Improvement in making decisions and levels of confidence were evaluated before and two weeks after the course, using image-based testing and a self- evaluation questionnaire. RESULTS All 57 final-year medical students attended the course and completed the tes...
Source: Medical Science Monitor - June 4, 2019 Category: Research Tags: Med Sci Monit Source Type: research

The Effects of Astragalus Polysaccharide on Bone Marrow-Derived Mesenchymal Stem Cell Proliferation and Morphology Induced by A549 Lung Cancer Cells.
CONCLUSIONS APS treatment reduced cell proliferation and morphological changes in bone marrow-derived MSCs that were co-cultured with A549 lung cancer cells in vitro. PMID: 31154455 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - June 4, 2019 Category: Research Tags: Med Sci Monit Source Type: research

miR-466 and NUS1 Regulate the AKT/Nuclear Factor kappa B (NF κB) Signaling Pathway in Intrauterine Adhesions in a Rat Model.
CONCLUSIONS Our data suggest that miR-466 and NUS1 regulate proliferation and the EMT process through the AKT/NFkappaB pathway in IUAs in a rat model. PMID: 31154456 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - June 4, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Comparison of Wrist Arthroscopy, Small Incision Surgery, and Conventional Surgery for the Treatment of Carpal Tunnel Syndrome: A Retrospective Study at a Single Center.
This study aimed to compare the efficacy and safety of wrist arthroscopy, small incision surgery, and conventional open carpal tunnel release surgery for the treatment of carpal tunnel syndrome. MATERIAL AND METHODS Patients with carpal tunnel syndrome (n=111) were treated with wrist arthroscopy (n=33), small incision surgery (n=40), and conventional open carpal tunnel release surgery (n=38). Incision length, duration of surgery, degree of intraoperative bleeding, recovery time, and findings at postoperative follow-up at one month, three months, and six months after surgery were recorded. Assessment included the two-point ...
Source: Medical Science Monitor - June 4, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Matrine Suppresses Reactive Oxygen Species (ROS)-Mediated MKKs/p38-Induced Inflammation in Oxidized Low-Density Lipoprotein (ox-LDL)-Stimulated Macrophages.
CONCLUSIONS ox-LDL increases inflammatory response in macrophages by activating the ROS-mediated MKKs/p38 MAPK-induced inflammatory signaling pathway. Matrine suppresses ox-LDL-induced inflammatory by inhibiting the MKKs/p38 MAPK signaling pathway. PMID: 31156213 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - June 4, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Screening Analysis of Sirtuins Family Expression on Anti-Inflammation of Resveratrol in Endothelial Cells.
CONCLUSIONS Our results suggest that resveratrol inhibiting oxidative stress production is associated with SIRT1, SIRT2, SIRT3, SIRT4, and SIRT5 pathways; attenuating CD40 expression was only associated with SIRT1 and SIRT5 pathways in TNF-alpha-induced endothelial cells injury. PMID: 31158122 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - June 4, 2019 Category: Research Tags: Med Sci Monit Source Type: research

The C79G Polymorphism of the β2-Adrenergic Receptor Gene, ADRB2, and Susceptibility to Pediatric Asthma: Meta-Analysis from Review of the Literature.
CONCLUSIONS The C79G polymorphism of the ADRB2 gene encoding ß2-AR was associated with a reduced risk for the development of pediatric asthma, particularly in the Asian population. PMID: 31142730 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - June 1, 2019 Category: Research Tags: Med Sci Monit Source Type: research

The Long Noncoding RNA, LINC01555, Promotes Invasion and Metastasis of Colorectal Cancer by Activating the Neuropeptide, Neuromedin U.
CONCLUSIONS Increased expression of LINC01555 was found in CRC tissues and promoted the invasion of CRC cells by upregulating the expression of NmU. PMID: 31144675 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - June 1, 2019 Category: Research Tags: Med Sci Monit Source Type: research

RNA-Binding Motif 4 (RBM4) Suppresses Tumor Growth and Metastasis in Human Gastric Cancer.
CONCLUSIONS It is hoped that these findings will improve our understanding of GC pathogenesis while also helping us to explore the feasibility of RBM4-targeted therapy for GC treatment. PMID: 31145716 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - June 1, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Analyzing Electroencephalography (EEG) Waves Provides a Reliable Tool to Assess the Depth of Sevoflurane Anesthesia in Pediatric Patients.
Authors: Beekoo D, Yuan K, Dai S, Chen L, Di M, Wang S, Liu H, ShangGuan W Abstract BACKGROUND Studies have reported that BIS is unreliable in children because its algorithm provides misleading information about the actual depth of anesthesia. Raw EEG analysis provides direct neurophysiologic measurement of cerebral activity. The relationship between age and EEG has rarely been reported, thus the aim of the present study was to compare raw electroencephalography (EEG) among different age groups of surgical patients under general anesthesia with 1.0 MAC sevoflurane. MATERIAL AND METHODS We enrolled 135 patients aged...
Source: Medical Science Monitor - June 1, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Lithium Chloride-Releasing 3D Printed Scaffold for Enhanced Cartilage Regeneration.
CONCLUSIONS 3D printed PCL-PDA-Li scaffolds promoted chondrogenesis in vitro and may provide a good method for lithium administration and be a potential candidate for cartilage tissue engineering. PMID: 31147532 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - June 1, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Gambogic Acid Shows Anti-Proliferative Effects on Non-Small Cell Lung Cancer (NSCLC) Cells by Activating Reactive Oxygen Species (ROS)-Induced Endoplasmic Reticulum (ER) Stress-Mediated Apoptosis.
CONCLUSIONS GA inhibited NSCLC cell proliferation by inducing ROS-induced ER stress-medicated apoptosis of NSCLC cells. PMID: 31138775 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - May 31, 2019 Category: Research Tags: Med Sci Monit Source Type: research

80 Years of the Medicine and Tropical Hygiene Center in Gdynia (1937-2017): The Pioneer Pre-War Years 1937-1939.
Authors: Knap JP, Nahorski WL, Kosińska B, Felczak-Korzybska I, Grabowski ML Abstract The present Interdepartmental Institute of Maritime and Tropical Medicine in Gdynia of the Medical University of Gdańsk was formally established in 1939 by the Order of June 5, 1939, of the Minister of Social Welfare, Marian Zyndram-Kościałkowski. However, the Branch of the National Institute of Hygiene in Gdynia was founded 2 years earlier, in 1937 (the first head was Dr. Med. Jerzy Jakóbkiewicz [1892-1953]), and its fruitful activity was ennobled 2 years later by increasing its rank and adding the name "Marine an...
Source: Medical Science Monitor - May 31, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Efficacy of Total Aortic Arch Replacement Combined with Frozen Elephant Trunk in Aortic Reoperation.
CONCLUSIONS The TAR+FET technique is feasible and efficacious for aortic reoperation in patients who previously underwent cardiac surgery since the short-term mortality in patients with recurrent aortic arch disease after cardiac surgery is not high. PMID: 31141498 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - May 31, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Assessment of Mean Platelet Volume in Patients with AA Amyloidosis and AA Amyloidosis Secondary to Familial Mediterranean Fever: A Retrospective Chart - Review Study.
This study was carried out on 27 patients with AA amyloidosis, 36 patients with AA amyloidosis secondary to FMF (a total of 63 patients with AA), and 29 healthy controls. There was no statistically significant difference between the AA patients and the control group (p=0.06) or between the AA-FMF group and the control group in terms of MPV values (p=0.12). RESULTS We found a statistically significant negative correlation between MPV and thrombocyte count in all groups (p
Source: Medical Science Monitor - May 30, 2019 Category: Research Tags: Med Sci Monit Source Type: research