The Potential Role of Nuclear Factor Erythroid 2-Related Factor 2 (Nrf2) in Glaucoma: A Review.
Authors: Wang M, Li J, Zheng Y Abstract Nuclear factor erythroid 2-related factor 2 (Nrf2) acts as a regulator of many biological processes and plays an essential role in preventing oxidation, inflammation, and fibrosis. In the past 20 years, there has been increasing research on the role of Nrf2 and oxidative stress in human glaucoma, including the roles of inflammation, trabecular meshwork cells, retinal ganglion cells, Tenon's capsule, antioxidants, fibrosis, and noncoding RNAs. Studies have shown that the upregulation of Nrf2 can reduce damage from oxidative stress in the trabecular meshwork cells and the retin...
Source: Medical Science Monitor - January 18, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Downregulation of SEMA4C Inhibit Epithelial-Mesenchymal Transition (EMT) and the Invasion and Metastasis of Cervical Cancer Cells via Inhibiting Transforming Growth Factor-beta 1 (TGF- β1)-Induced Hela cells p38 Mitogen-Activated Protein Kinase (MAPK) Activation.
This study investigated the relationship between the regulation of SEMA4C on TGF-ß1-induced p38 mitogen-activated protein kinase (MAPK) activation and invasion and metastasis of cervical cancer. MATERIAL AND METHODS Hela-shSEMA4C cell line was established and the success of transfection was confirmed with fluorescence intensity. Cell experiments were divided into 2 groups. Group 1 was Hela, Hela-shNC, and Hela-shSEMA4C; and Group 2 was Hela, Hela-shNC, Hela-shSEMA4C, Hela+TGF-ß1, Hela-shNC+TGF-ß1, and Hela-shSEMA4C+TGF-ß1. Group 1 was detected for SEMA4C mRNA expression by real-time polymerase chain...
Source: Medical Science Monitor - January 18, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Long Non-Coding RNA (lncRNA) BMP/OP-Responsive Gene (BORG) Promotes Development of Chemoresistance of Colorectal Cancer Cells to Carboplatin.
CONCLUSIONS BORG promotes the development of chemoresistance of CRC cells to carboplatin. PMID: 31937750 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - January 17, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Interaction of Nuclear Receptor Subfamily 4 Group A Member 1 (Nr4a1) and Liver Linase B1 (LKB1) Mitigates Type 2 Diabetes Mellitus by Activating Monophosphate-Activated Protein Kinase (AMPK)/Sirtuin 1 (SIRT1) Axis and Inhibiting Nuclear Factor-kappa B (NF- κB) Activation.
CONCLUSIONS Our results highlight that interaction of Nr4a1 and LKB1 can mitigate T2DM by activating the AMPK/SIRT1 signaling pathway and inhibiting NF-kappaB activation. This may offer new insight for T2DM treatment. PMID: 31939452 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - January 17, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Differential Influence of Location-Specific White-Matter Hyperintensities on Attention Subdomains Measured Using the Attention Network Test.
Authors: Wang B, Zhang J, Pan W, Cao S, Li B, Bai L, Hu P, Tian Y, Jiang D, Wang K Abstract BACKGROUND Elderly people with white-matter hyperintensities (WMHs) typically show cognitive impairment. Attention, consisting of 3 independent component processes (alerting, orienting, and executive control), is crucial for cognitive functioning. Little is known about how WMHs interfere with these attention subdomains. In the present study, we sought to describe characteristics of attention deficits in patients with age-related WMHs and to assess whether the severity and location of lesions differentially affect specific at...
Source: Medical Science Monitor - January 17, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Evaluation of a Three-Dimensional Printed Guide and a Polyoxymethylene Thermoplastic Regulator for Percutaneous Pedicle Screw Fixation in Patients with Thoracolumbar Fracture.
CONCLUSIONS The use of a porous polyoxymethylene thermoplastic regulator combined with a 3D printed template may improve the success of pedicle insertion in patients undergoing PPSF. PMID: 31932574 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - January 15, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Hsa_circ_0086414 Might Be a Diagnostic Biomarker of Oral Squamous Cell Carcinoma.
CONCLUSIONS We discovered that hsa_circ_0086414 might be an essential diagnostic biomarker in OSCC. Furthermore, hsa_circ_0086414 could be a target for OSCC therapy. PMID: 31933490 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - January 15, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Naturally Occurring Sclareol Diterpene Augments the Chemosensitivity of Human Hela Cervical Cancer Cells by Inducing Mitochondrial Mediated Programmed Cell Death, S-Phase Cell Cycle Arrest and Targeting Mitogen-Activated Protein Kinase (MAPK)/Extracellular-Signal-Regulated Kinase (ERK) Signaling Pathway.
CONCLUSIONS Sclareol not only induced cytotoxic effects but also enhanced chemosensitivity of human cervical cancer cells towards cisplatin and these effects are mediated via MAPK/ERK signaling pathway, stimulation of apoptosis and S-phase cell cycle arrest. PMID: 31935210 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - January 15, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Inhibition of Splicing Factor 3b Subunit 1 (SF3B1) Reduced Cell Proliferation, Induced Apoptosis and Resulted in Cell Cycle Arrest by Regulating Homeobox A10 (HOXA10) Splicing in AGS and MKN28 Human Gastric Cancer Cells.
CONCLUSIONS In AGS and MKN28 human gastric cancer cells in vitro, inhibition of SF3B1 reduced cell proliferation, induced apoptosis, and resulted in cell cycle arrest by regulating HOXA10 splicing. PMID: 31927557 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - January 14, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Protective Effects of Hydrogen-Rich Water Against Cartilage Damage in a Rat Model of Osteoarthritis by Inhibiting Oxidative Stress, Matrix Catabolism, and Apoptosis.
CONCLUSIONS HW showed a protective effect against the progression of OA in an animal model, which may have been mediated by its anti-oxidant and anti-apoptotic activities. PMID: 31927559 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - January 14, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Naringin Protects Against Interleukin 1 β (IL-1β)-Induced Human Nucleus Pulposus Cells Degeneration via Downregulation Nuclear Factor kappa B (NF-κB) Pathway and p53 Expression.
CONCLUSIONS These results demonstrated that naringin could attenuate matrix metalloproteinase catabolism and inflammation in IL-1ß-treated human nucleus pulposus cells via downregulating NF-kappaB pathway and p53 expression, suggesting that naringin has the potential to prevent and treat IDD. PMID: 31927560 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - January 14, 2020 Category: Research Tags: Med Sci Monit Source Type: research

The Nephroprotective Effect of TNF Receptor-Associated Factor 6 (TRAF6) Blockade on LPS-Induced Acute Renal Injury Through the Inhibition if Inflammation and Oxidative Stress.
CONCLUSIONS Our findings provide direct evidence that TRAF6 mediates LPS-induced inflammation and oxidative stress, leading to renal dysfunction. We also show that TRAF6 inhibition is a potential therapeutic option to prevent AKI. PMID: 31929494 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - January 14, 2020 Category: Research Tags: Med Sci Monit Source Type: research

The Prognostic Role of a Combined Fibrinogen and Neutrophil-to-Lymphocyte Ratio Score in Patients with Resectable Hepatocellular Carcinoma: A Retrospective Study.
Authors: Kong W, Xu H, Cheng J, Fang Z, Wang H, Zhang J, Wang X, Dai T, Gao Y Abstract BACKGROUND Inflammation and activation of the coagulation cascades have a role in the pathogenesis of malignancy, including hepatocellular carcinoma (HCC). This retrospective study aimed to investigate the prognostic role of the combined fibrinogen and neutrophil-to-lymphocyte ratio (F-NLR) in patients with resectable HCC. MATERIAL AND METHODS This retrospective study included 292 patients with HCC who underwent surgical resection. The receiver operating characteristic (ROC) curve was used to determine the cut-off value of preope...
Source: Medical Science Monitor - January 14, 2020 Category: Research Tags: Med Sci Monit Source Type: research

The Effect of Mitomycin C on Reducing Endometrial Fibrosis for Intrauterine Adhesion.
CONCLUSIONS Our findings revealed that mitomycin C could reduce endometrial fibrosis for intrauterine adhesion. PMID: 31929497 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - January 14, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Ultrasound Computer-Aided Diagnosis (CAD) Based on the Thyroid Imaging Reporting and Data System (TI-RADS) to Distinguish Benign from Malignant Thyroid Nodules and the Diagnostic Performance of Radiologists with Different Diagnostic Experience.
CONCLUSIONS The use of ultrasound CAD based on the TI-RADS showed potential for distinguishing between benign and malignant thyroid nodules and improved the diagnostic performance of junior radiologists. PMID: 31929498 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - January 14, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Clinical Effect of Tunnel-Like Fistulectomy Plus Draining Seton Combined with Incision of Internal Opening of Anal Fistula (TFSIA) in the Treatment of High Trans-Sphincteric Anal Fistula.
Authors: Yan J, Ma L Abstract BACKGROUND The aim of this study was to investigate the clinical effect of tunnel-like fistulectomy plus draining seton combined with incision of internal opening of anal fistula (TFSIA) in the treatment of high transsphincteric anal fistula. MATERIAL AND METHODS There were 80 patients with high transsphincteric anal fistula randomly divided into TFSIA group and control group, 40 cases in each group. The control group was treated with cutting seton, and the seton was tightened weekly after discharge from the hospital until the seton dropped off. In the TFSIA group, the anal fistula was...
Source: Medical Science Monitor - January 14, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Identification of CXCR4 and CXCL10 as Potential Predictive Biomarkers in Triple Negative Breast Cancer (TNBC).
CONCLUSIONS Our research found that CXCR4 and CXCL10 overexpressed, and they were a favorable prognostic factor in patients with TNBC. CXCR4 and CXCL10 might be effective targets for TNBC therapy. PMID: 31924747 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - January 13, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Tailgut Cysts with Malignant Transformation: Features, Diagnosis, and Treatment.
Authors: Liang F, Li J, Yu K, Zhang K, Liu T, Li J Abstract A tailgut cyst is a type of benign congenital disease that mainly develops in the retro-rectal space. However, malignant transition can occur in some cases of tailgut cysts. Early and precise diagnosis, and proper treatment, are vital for patients with tailgut cysts with malignant transformation. In this review, we aim to summarize the similarities and differences in the diagnosis and treatment methods among the 3 most frequently reported types of tailgut cysts with malignant transformation. In our study, PubMed and Web of Science databases were used to se...
Source: Medical Science Monitor - January 13, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Roles of Fibulin-2 in Carcinogenesis.
Authors: Zhang H, Hui D, Fu X Abstract Fibulin-2, an extracellular matrix (ECM) protein expressed in normal epithelia, is a kind of fibulin which is associated with basement membranes (BM) and elastic ECM fibers. The role of fibulin-2 has been recognized as an oncogene. The upregulation of fibulin-2 correlates with cancer development and progression. Furthermore, the upregulation of fibulin has been detected in ovarian cancer and stomach adenocarcinoma. However, the downregulation of fibulin has been detected in different intestinal and respiratory tumor cells. Additional studies have revealed that the role of fibu...
Source: Medical Science Monitor - January 11, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Proteomics and Bioinformatics Analysis of Cartilage in Post-Traumatic Osteoarthritis in a Mini-Pig Model of Anterior Cruciate Ligament Repair.
This study aimed to undertake proteomics and bioinformatics analysis of cartilage in PTOA in a mini-pig model of anterior cruciate ligament repair (ACLR). MATERIAL AND METHODS The mini-pig model of PTOA involved autologous orthotopic ACLR. Screening and identification of differentially expressed proteins in the knee joint cartilage in the OA cartilage group were compared with the control group using tandem mass tag (TMT)-labeling liquid chromatography with tandem mass spectrometry (LC-MS-MS). A protein expression level>1.2 fold-change represented protein upregulation and
Source: Medical Science Monitor - January 11, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Characteristics of Cerebral Stroke in the Tibet Autonomous Region of China.
This article focuses on epidemiology features, risk factors, and pathogenesis of stroke in the TAR in an effort to generate a better understanding of the characteristics of stroke in this region. The special plateau-related factors such as its high elevation, limited oxygen, the high incidence of hypertension, smoking, and the unique dietary habits of the region are correlated with the high incidence of stroke. In addition to these factors, the pathogenesis of stroke in this high-altitude area is also unique. However, there is no established explanation for the unique occurrence and high incidence of stroke in the TAR. Our...
Source: Medical Science Monitor - January 11, 2020 Category: Research Tags: Med Sci Monit Source Type: research

3,6-diazabicyclo[3.3.1]heptanes Induces Apoptosis and Arrests Cell Cycle in Prostate Cancer Cells.
Authors: Wei H, Lian W, Wang C Abstract BACKGROUND Prostate cancer, non-cutaneous malignant tumor, is the second common cause of cancer related mortalities in American men and is responsible for 13% of deaths related to cancer. The present study investigated the anti-cancer effects of 3,6-diazabicyclo[3.3.1]heptane on LNCaP and PC3 prostate cancer cells in vitro and on tumor growth in vivo in BALB/C nude mice. MATERIAL AND METHODS Reduction of cell viability by 3,6-diazabicyclo[3.3.1]heptane was evaluated by sulphorhodamine-B staining and apoptosis onset using annexin V and propidium iodide (PI) staining. The 2',7'...
Source: Medical Science Monitor - January 11, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Body Mass Index and Major Adverse Cardiovascular Events: A Secondary Analysis Based on a Retrospective Cohort Study.
Authors: Liu X, Liu P Abstract BACKGROUND The association between body mass index (BMI) and major adverse cardiovascular events (MACE) has not been clarified and is controversial. Therefore, the purpose of present study is to explore the association between BMI and MACE. MATERIAL AND METHODS This was a secondary analysis of a retrospective cohort study in which 204 participants who were diagnosed with stable coronary artery disease (CAD) and received elective percutaneous coronary intervention (PCI) were recruited. According to the BMI, patients were divided into 3 categories - underweight (BMI
Source: Medical Science Monitor - January 11, 2020 Category: Research Tags: Med Sci Monit Source Type: research

N-myc Downstream-Regulated Gene 2 (NDRG2) Promotes Bone Morphogenetic Protein 2 (BMP2)-Induced Osteoblastic Differentiation and Calcification by Janus Kinase 3 (JAK3)/Signal Transducer and Activator of Transcription 3 (STAT3) Signaling Pathway.
CONCLUSIONS The presented data indicated that NDRG2 promoted BMP2-induced osteoblastic differentiation and calcification by activating the JAK3/STAT3 signal pathway. PMID: 31911574 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - January 10, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Dexmedetomidine Post-Conditioning Alleviates Cerebral Ischemia-Reperfusion Injury in Rats by Inhibiting High Mobility Group Protein B1 Group (HMGB1)/Toll-Like Receptor 4 (TLR4)/Nuclear Factor kappa B (NF- κB) Signaling Pathway.
CONCLUSIONS Dexmedetomidine post-conditioning can alleviate cerebral ischemia-reperfusion injury in rats by inhibiting the HMGB1/TLR4/NF-kappaB signaling pathway. PMID: 31912804 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - January 10, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Fluid Shear Stress Suppresses Osteoclast Differentiation in RAW264.7 Cells through Extracellular Signal-Regulated Kinase 5 (ERK5) Signaling Pathway.
CONCLUSIONS Our findings demonstrated that FSS inhibited osteoclast differentiation in RAW264.7 cells via the ERK5 pathway through reduced NFATc1 expression and its downstream factors MMP-9, CTSK, and TRAP. PMID: 31914120 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - January 10, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Clinical Significance of High-Mobility Group Box 1 Protein (HMGB1) and Nod-Like Receptor Protein 3 (NLRP3) in Patients with Ulcerative Colitis.
CONCLUSIONS Both serum NLRP3 and HMGB1 were elevated in UC patients, and the serum levels of NLRP3 were positively correlated with serum levels of HMGB1, ET-1, IL-1ß, and TNF-alpha, as well as severity of UC patients. PMID: 31901930 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - January 8, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Prediction of Prolonged Length of Stay for Stroke Patients on Admission for Inpatient Rehabilitation Based on the International Classification of Functioning, Disability, and Health (ICF) Generic Set: A Study from 50 Centers in China.
This study aimed to develop a risk prediction model for prolonged length of stay (LOS) in stroke patients in 50 inpatient rehabilitation centers in 20 provinces across mainland China based on the International Classification of Functioning, Disability, and Health (ICF) Generic Set case mix on admission. MATERIAL AND METHODS In this cohort study, 383 stroke patients were included from inpatient rehabilitation settings of 50 hospitals across mainland China. Independent predictors of prolonged LOS were identified using multivariate logistic regression analysis. A prediction model was established and then evaluated by receiver...
Source: Medical Science Monitor - January 8, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Lysophosphatidic Acid Receptor 5 (LPAR5) Plays a Significance Role in Papillary Thyroid Cancer via Phosphatidylinositol 3-Kinase/Akt/Mammalian Target of Rapamycin (mTOR) Pathway.
CONCLUSIONS In summary, downregulation of LPAR5 expression can inhibit the physiological process of PTC, and this phenomenon is related to the PI3K/AKT pathway and EMT. PMID: 31902939 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - January 8, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Relationship Between Pituitary Adenoma Consistency and Extent of Resection Based on Tumor/Cerebellar Peduncle T2-Weighted Imaging Intensity (TCTI) Ratio of the Point on Preoperative Magnetic Resonance Imaging (MRI) Corresponding to the Residual Point on Postoperative MRI.
In this study, we proposed a method of predicting consistency by magnetic resonance T2-sequence imaging based on adenoma to cerebellar peduncle signal (TCTI) ratio. MATERIAL AND METHODS Between January 2013 and May 2017, 191 consecutive patients with pituitary adenoma diagnosed at our institution were retrospectively studied. The consistency grade for each lesion was assigned. And the TCTI ratio based on preoperative and postoperative T2-weighted imaging was calculated. RESULTS The median TCTI ratio was 1.55, 1.28, and 1.25 for soft, fibrous, and hard adenomas, respectively. The differences were significant for all groups (p
Source: Medical Science Monitor - January 8, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Epidemiological Investigation of Elderly Patients with Severe Burns at a Major Burn Center in Southwest China.
CONCLUSIONS At a major burn center in Southwest China, the incidence and mortality of elderly patients with severe burns displayed no downward trend. There are etiological characteristics of these age groups that should be considered for prevention. Meanwhile, multidisciplinary treatment in a hospital and an increase in the social support for the elderly population might improve outcomes. PMID: 31905188 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - January 8, 2020 Category: Research Tags: Med Sci Monit Source Type: research

A Comparative Study of C2 Pedicle or Pars Screw Placement with Assistance from a 3-Dimensional (3D)-Printed Navigation Template versus C-Arm Based Navigation.
CONCLUSIONS Although 3D-printed navigation template-assisted and C-arm based navigation-assisted C2 pedicle and pars screw placement provided similar safety and clinical efficacy, 3D-printed navigation template technology achieved more accurate C2 pedicle screw placement. PMID: 31907341 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - January 8, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Portable 3D-Head Computed Tomography (CT) Navigation-Guided Key-Hole Microsurgery for Spontaneous Hypertensive Hemorrhages.
Authors: Zhang HT, Chen LH, Xu RX Abstract BACKGROUND This case series study evaluated the outcome and effect of portable 3D-head computed tomography (CT, MCT-I, 16 rows mobile CT made in China) navigation-guided key-hole microsurgery for supratentorial hypertensive hematomas. MATERIAL AND METHODS Thirty-five consecutive unconscious patients with a significant volume of hypertensive intracranial hemorrhages (HICH) were treated with 3D image-guided key-hole microsurgery, and the clinical features were summarized. Preoperative and postoperative hematoma volumes and reduction in midline shifts were calculated and reco...
Source: Medical Science Monitor - January 8, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Does Type of Menopause Affect the Sex Lives of Women?
Authors: Bıldırcın FD, Özdeş EK, Karlı P, Özdemir AZ, Kökçü A Abstract BACKGROUND The aim of this study was to investigate factors affecting the sex lives of middle-aged women, and whether surgical menopause affects sexual function differently from natural menopause, by comparing effects on sexual performance of women with similar demographic features. MATERIAL AND METHODS The study included 151 women with surgical menopause (SM), 357 women with natural menopause (NM), and 186 perimenopausal women (PM). The women were asked to complete a 6-question survey of sexual performance parame...
Source: Medical Science Monitor - January 8, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Indirect Regulation and Equilibrium of p35 and p40 Subunits of Interleukin (IL)-12/23 by Ustekinumab in Psoriasis Treatment.
CONCLUSIONS We concluded that 2 equilibria influence the efficacy of ustekinumab against psoriasis. First, because of the dual roles of p35 in psoriasis pathogenesis, homeostasis occurs between p35 and p40 expression levels. The second balance lies between the upregulation of p40 mRNA levels and the ability of ustekinumab to neutralize the function of the elevated p40 protein. PMID: 31910201 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - January 8, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Induction of Apoptosis in Lung Cancer Cells by Viburnum grandiflorum via Mitochondrial Pathway.
Authors: Han B, Wu J, Huang L Abstract BACKGROUND Lung cancer is one of the leading causes of mortality and morbidity. Viburnum grandiflorum is a medicinal herb known for its wide spectrum of pharmacological activities, but its anti-cancer properties against lung cancer cells have not been previously investigated. The present study elucidated the antitumor effect and associated mechanism of methanol extract of Viburnum grandiflorum extract (VGE) against lung cancer cells. MATERIAL AND METHODS The viability of H1650, HCC827, and H1299 cells was measured using MTT assay. Apoptosis and cell cycle progression were dete...
Source: Medical Science Monitor - January 5, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Protective Effects of Naringin in Cerebral Infarction and Its Molecular Mechanism.
CONCLUSIONS Naringin played a protective role in cerebral infarction via suppressing neuronal apoptosis and inflammation. PMID: 31901198 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - January 5, 2020 Category: Research Tags: Med Sci Monit Source Type: research

S100A16 Regulates HeLa Cell through the Phosphatidylinositol 3 Kinase (PI3K)/AKT Signaling Pathway.
Authors: Zhang H, Yang Y, Ma X, Xin W, Fan X Abstract BACKGROUND S100 calcium-binding protein A16 (S100A16) is closely related to the onset and progression of tumors. MATERIAL AND METHODS In the research, the mainly purpose was to investigate the effect of S100A16 on the proliferation ability, invasion, and angiogenesis of HeLa cells. An adenoviral vector overexpressing S100A16 (Ad-S100A16) was constructed and transfected into HeLa cells, forming a stable cells line of overexpression. The effect of S100A16 on the proliferative capacity of HeLa cells was evaluated by a Cell Counting Kit-8 (CCK-8) assay. Cell migrati...
Source: Medical Science Monitor - January 4, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Evaluation of the Precision of Different Intraoral Scanner-Computer Aided Design (CAD) Software Combinations in Digital Dentistry.
CONCLUSIONS Within the limitations of this in vitro study, it was determined that the combinations of scanners and associated CAD programs yielded more accurate results, and data loss was revealed when the scanned data converted from the proprietary format to the STL format. PMID: 31896741 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - January 4, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Evaluating the Changes of White Matter Microstructures in Tobacco Addicts Based on Diffusion Tensor Imaging.
Authors: Huang H, Zhang Y, Cheng J, Wang W, Wen M Abstract BACKGROUND The tract-based spatial statistics (TBSS) method was used to investigate the changes of white matter microstructure in tobacco addicts, and to analyze its correlation with smoking index, smoking years, and daily smoking amount. MATERIAL AND METHODS Routine magnetic resonance imaging (excluding intracranial lesions) and diffusion tensor imaging (DTI) sequence scanning were performed in 156 nicotine addicts (nicotine dependence group) and 81 non-nicotine addicts (control group) recruited from the study group. TBSS method was used to preprocess DTI ...
Source: Medical Science Monitor - January 4, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Analysis of National Health and Insurance Registers for All-Cause Mortality in Patients with Heart Failure with and without Diabetes Mellitus in Poland in 2012.
CONCLUSIONS These findings support the need for continued prevention programs, early diagnosis, and treatment of diabetes, and highlight the increase in mortality for patients with heart failure and diabetes. PMID: 31892692 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - January 3, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Network Pharmacology-Based Study on the Molecular Biological Mechanism of Action for Compound Kushen Injection in Anti-Cancer Effect.
CONCLUSIONS This study was based on pharmacological networks results for the prediction of the multi-constituent, multi-target, and multi-pathway mechanisms of CKI, which might be a promising potential therapeutic and prevention candidate for anti-cancer. However, based on computer data mining and analysis, this study still needs to be further verified by in vivo/in vitro experiments, and the safety of CKI needs to be evaluated. PMID: 31892693 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - January 3, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Use of Laparoscopic Slip Knot with Purse-String Suture in Surgical Management of Unruptured Heterotopic Interstitial Pregnancies.
CONCLUSIONS This strategy is safe and reliable for gestational sac clearance while simultaneously preventing any potential harm to the intrauterine embryo. It is particularly suitable for unruptured HIP patients who have a strong desire to preserve their intrauterine embryos. PMID: 31893477 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - January 3, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Integrative Gene Expression Profiling Analysis to Investigate Potential Prognostic Biomarkers for Colorectal Cancer.
CONCLUSIONS The 7 genes that we identified would provide more evidence for further applying novel diagnostic and prognostic biomarkers in clinical practice to facilitate personalized treatment of CRC. PMID: 31893510 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - January 3, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Elastic Net-Based Identification of a Multigene Combination Predicting the Survival of Patients with Cervical Cancer.
The objective of the present study was to identify prognostication biomarkers in patients with cervical cancer. MATERIAL AND METHODS Survival related genes were identified in The Cancer Genome Atlas (TCGA) cervical cancer study, and they were included into an elastic net regularized Cox proportional hazards regression model (CoxPH). The genes that their coefficients that were not zero were combined to build a prognostication combination. The prognostication performance of the multigene combination was evaluated and validated using Kaplan-Meier curve and univariate and multivariable CoxPH model. Meanwhile, a nomogram was bu...
Source: Medical Science Monitor - January 1, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Incidence of Stroke and Mortality in Chinese Patients with Sleep-Breathing Disorders: A Clinical Population-Based (CPB) Study.
The objective of this study was to investigate the incidence of stroke and death in patients with sleep-breathing disorders. MATERIAL AND METHODS The anthropometric characteristics, demographic data, and incidence of stroke of 1492 Chinese patients with mild, moderate, or severe sleep apnea were collected. The apnea-hypopnea index was used to define sleep-breathing disorders. Imaging modalities were used to validate the diagnosis of stroke. Death during hospitalization or during follow-up was noted. Multivariate analysis was performed for the incidence of stroke and mortality at the 95% of confidence level. RESULTS Among e...
Source: Medical Science Monitor - January 1, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Analysis of Long Non-Coding RNA Expression Profile and Functional Study of LOC389332 in Early Gastric Cancer.
CONCLUSIONS The LncRNA expression profile between EGC and gastritis tissues was significantly different. LOC389332 was potential non-coding oncogenes in gastric cancer, and it may perform its function through altering cell membrane function, signal transmission, and cell adhesion. PMID: 31884510 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - January 1, 2020 Category: Research Tags: Med Sci Monit Source Type: research

MicroRNA-106a-3p Induces Apatinib Resistance and Activates Janus-Activated Kinase 2 (JAK2)/Signal Transducer and Activator of Transcription 3 (STAT3) by Targeting the SOCS System in Gastric Cancer.
CONCLUSIONS miR-106a-3p induces apatinib resistance and activates JAK2/STAT3 by targeting SOCS system in gastric cancer. miR-106a-3p/SOCS plays a potent role in gastric cancer cell resistance to apatinib. PMID: 31884511 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - January 1, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Risk Factors for Incidence and Prognosis in Chondrosarcoma Patients with Pulmonary Metastasis at Initial Diagnosis.
CONCLUSIONS The incidence of pulmonary metastasis in chondrosarcoma was approximately 6.8%, with poor prognosis. Identifying risk factors and their associations with the incidence and prognosis in chondrosarcoma patients with pulmonary metastasis could provide a reference for clinical surveillance and guide the design of personalized treatment plans. PMID: 31885034 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - January 1, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Brain-Derived Neurotrophic Factor Alleviates Ropivacaine-Induced Neuronal Damage by Enhancing the Akt Signaling Pathway.
CONCLUSIONS BDNF can alleviate ropivacaine-induced neuronal injury by activating Akt signaling pathway, consequently modulating the proliferation and apoptosis of neurons. PMID: 31885368 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - January 1, 2020 Category: Research Tags: Med Sci Monit Source Type: research