Behaviorally-Mediated Entrainment of Whole-Body Metabolic Processes: Conservation and Evolutionary Development of Mitochondrial Respiratory Complexes.
Authors: Stefano GB, Esch T, Kream RM Abstract The relaxation response derives its health benefits by reestablishing "normal" equilibria between the sympathetic and parasympathetic branches of the autonomic nervous system. Recent work suggests that this behavioral training provides positive effects on mitochondrial bioenergetics, insulin secretion, and reductions in pro-inflammatory and stress-related pathways. We have previously contended, however, that correlative associations of relaxation training with positive changes in gene expression in selected biological systems are strongly suggestive of adapti...
Source: Medical Science Monitor - December 8, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Orai1 Promotes Osteosarcoma Metastasis by Activating the Ras-Rac1-WAVE2 Signaling Pathway.
Authors: Guo Y, Zhu J, Wang X, Li R, Jiang K, Chen S, Fan J, Xue L, Hao D Abstract BACKGROUND The purpose of this study was to investigate whether Orai1 plays a role in the metastasis of osteosarcoma. MATERIAL AND METHODS The expression of Orai1 was silenced by small interfering RNAs against Orai1 (Orai1 siRNA) in osteosarcoma MG-63 cells. Various experiments were carried out to detect the changes in migration, invasion, and adhesion ability of these osteosarcoma cells. Furthermore, the activity of Rac1, Wave2, and Ras was detected using Western blot analysis. Moreover, the Rac1 and Ras inhibitors were used to conf...
Source: Medical Science Monitor - December 7, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Differently Expressed Genes (DEGs) Relevant to Type 2 Diabetes Mellitus Identification and Pathway Analysis via Integrated Bioinformatics Analysis.
CONCLUSIONS DEGs of T2DM may play an essential role in disease development and may be potential pathogeneses of T2DM. PMID: 31797865 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - December 7, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Phylogenetic and Epidemiological Analysis of Measles Viruses in Shenzhen, China from January 2015 to July 2019.
CONCLUSIONS Our results showed there was a seasonal measles outbreak in Shenzhen Children's Hospital. All the measles virus from 129 measles patients were H1 viruses. The clinical signs also showed a difference between unvaccinated and vaccinated patients. Moreover, most of the unvaccinated patients came from migrant worker families. We suggest there is a need for increased health promotion and vaccination programs for migrant workers and people living in remote villages. PMID: 31800568 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - December 7, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Bioinformatics Analysis of Key Genes and Pathways Associated with Thrombosis in Essential Thrombocythemia.
CONCLUSIONS Bioinformatics analysis identified DEGs and hub genes that interacted with CD34+ cells and neutrophils that may predict an increased risk of thrombosis in patients with ET. These preliminary findings should be validated using next-generation sequencing (NGS) and clinical studies. PMID: 31801935 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - December 7, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Quantitative and Qualitative Evaluation of Breast Cancer Prognosis: A Sonographic Elastography Study.
CONCLUSIONS Elastography is a useful imaging technique in differentiating benign breast masses from malignant ones. The strong relationship between prognostic factors and elastographic measures also demonstrated its excellent performance in predicting the prognosis of breast malignancies. PMID: 31802780 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - December 7, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Identification and Integrated Analysis of Key Biomarkers for Diagnosis and Prognosis of Non-Small Cell Lung Cancer.
Authors: Liu X, Liu X, Li J, Ren F Abstract Non-small cell lung cancer (NSCLC) is the main histologic form of lung cancer that affects human health, but biomarkers for therapeutic diagnosis and prognosis of the disease are currently lacking. The gene expression profile GSE18842 was downloaded from the Gene Expression Omnibus database in this prospective study, which consisted of 46 tumors and 45 controls. After screening differentially expressed genes (DEGs), we conducted functional enrichment analysis and KEGG analysis with upregulated differentially expressed genes (uDEGs) and downregulated differentially express...
Source: Medical Science Monitor - December 7, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Vitamin D3 Is Transformed into 1,25(OH)2D3 by Triggering CYP3A11(CYP3A4) Activity and Hydrolyzing Midazolam.
This study aimed to investigate effects of vitamin D3 (VD3) on CYP3A11 activity. MATERIAL AND METHODS Forty male Sprague-Dawley (SD) rats were randomly divided a Control group (peanut oil 0.1 ml/kg/d), a Low-VD3 group (100 IU/kg/d), a Medium-VD3 group (400 IU/kg/d), and a High-VD3 (1600 IU/kg/d) group. Blood samples were collected from the jugular vein after midazolam (MDZ) administration. CYP3A11 expressions in liver and colon were detected by Western blotting and immunohistochemistry (IHC) assay. The concentration of serum 25(OH)D₃ and serum 1,25(OH)₂D₃ were evaluated using ELISA. Effects of different dosages of vi...
Source: Medical Science Monitor - December 5, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Construction and Validation of Nomograms for Predicting Overall Survival and Cancer-Specific Survival in Nonmetastatic Inflammatory Breast Cancer Patients Receiving Tri-Modality Therapy: A Population-Based Study.
Authors: Huang Q, Xu TY, Wu ZY Abstract BACKGROUND As the most aggressive breast cancer, inflammatory breast cancer (IBC) has a poor prognosis. However, analyzing the prognostic factors of IBC is challenging due to its rarity. We identified the prognostic factors to establish predictive tools for survival in nonmetastatic IBC patients who received tri-modality therapy. MATERIAL AND METHODS The data of 893 nonmetastatic IBC patients were acquired from the Surveillance, Epidemiology, and End Results (SEER) database. IBC was identified by "ICD-O-3=8530" or "AJCC T, 7th=T4d"). Patients were randomiz...
Source: Medical Science Monitor - December 5, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Comparison of Regorafenib, Fruquintinib, and TAS-102 in Previously Treated Patients with Metastatic Colorectal Cancer: A Systematic Review and Network Meta-Analysis of Five Clinical Trials.
CONCLUSIONS The findings from network meta-analysis showed that fruquintinib was associated with significant superiority for PFS and DCR compared with TAS-102, but fruquintinib was associated with significantly increased risk for SAEs compared with regorafenib and TAS-102. PMID: 31790382 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - December 5, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Effect of Spinal Shortening for Protection of Spinal Cord Function in Canines with Spinal Cord Angulation.
CONCLUSIONS When the spinal cord is shortened by 1/4 to 2/4, the tolerance of the spinal cord can increase and spinal cord injury resulting from angulation can be avoided. However, when the shortening reaches 3/4, it is harmful to the spinal cord. Proper shortening of the spinal cord by 1/4 to 2/4 may increase the tolerance of the spinal cord to the damage caused by angulation during PVCR. PMID: 31791038 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - December 5, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Serum Cystatin C and Arterial Stiffness in Middle-Aged and Elderly Adults without Chronic Kidney Disease: A Population-Based Study.
CONCLUSIONS In middle-aged and elderly individuals without CKD, arterial stiffness determined by obesity, dyslipidemia and increased pulse pressure, was significantly associated with increased serum levels of cystatin C. PMID: 31793519 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - December 5, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Identification for Exploring Underlying Pathogenesis and Therapy Strategy of Oral Squamous Cell Carcinoma by Bioinformatics Analysis.
CONCLUSIONS Our study using an integrated bioinformatics analysis might provide valuable information for exploring potential new molecular biomarkers and therapeutic targets for OSCC. PMID: 31794546 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - December 5, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Comparison of the Analgesic and Anti-Inflammatory Effects of Xiaoyuningkun Decoction with Cynanchum Paniculatum and Fukeqianjin in a Mouse Model of Pelvic Inflammatory Disease.
CONCLUSIONS The new xiaoyuningkun decoction had analgesic and anti-inflammatory effects in the mouse model of PID, possibly by inhibiting ICAM-1, VEGF, and inflammatory cytokines. PMID: 31784502 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - December 2, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Adolescent Hyperuricemia with Lipid Storage Myopathy: A Clinical Study.
CONCLUSIONS If an adolescent hyperuricemia patient has abnormal limb weakness, exercise intolerance, and elevated serum CK values, clinicians need to be highly alert to the possibility of LSM. Early diagnosis and treatment of LSM should improve the clinical symptoms and quality of life and reduce complications. PMID: 31785094 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - December 2, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Nitric Oxide and Cyclic Guanosine Monophosphate Signaling Mediates the Antidepressant Effects of Acupuncture in the Rat Model of Chronic Unpredictable Mild Stress.
CONCLUSIONS In the CUMS rat model, treatment with acupuncture reduced behaviors associated with depression, and these effects were associated with changes in the NO and cGMP signaling pathway. PMID: 31785199 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - December 2, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Laparoscopic Disconnected Pyeloplasty to Treat Ureteropelvic Junction Obstruction (UPJO) in Children.
CONCLUSIONS Laparoscopic disconnected pyeloplasty to treat UPJO in young children has the same early clinical effectiveness and safety as open surgery, and this procedure has the advantages of minimal trauma, quick recovery, and good cosmetic effect. PMID: 31786579 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - December 2, 2019 Category: Research Tags: Med Sci Monit Source Type: research

A Single-Nucleotide Polymorphism (rs1131243) of the Transforming Growth Factor Beta Signaling Pathway Contributes to Risk of Acute Rejection in Chinese Renal Transplant Recipients.
CONCLUSIONS In this study, we observed that the SNP rs1131243 on the TGF-ßR3 gene was significantly associated with the occurrence of AR in Chinese renal transplant recipients. PMID: 31786580 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - December 2, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Ulinastatin Reduces the Severity of Intestinal Damage in the Neonatal Rat Model of Necrotizing Enterocolitis.
CONCLUSIONS Ulinastatin could ameliorate the severity of intestinal damage in NEC and possess anti-apoptosis and anti-inflammation effects. PMID: 31786582 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - December 2, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Integrative Analysis of Expression Profiles of MicroRNAs and mRNAs in Treatment of Acute Myocardial Infarction with Compound Longmaining Decoction.
CONCLUSIONS The analysis based on the miRNA-mRNA network can not only help to elucidate the potential molecular mechanism of CLMN treatment of AMI, but can also help in identifying novel therapeutic targets. PMID: 31776323 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - December 1, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Expression and Regulation of Brain Natriuretic Peptide and Natriuretic Peptide Receptor A (NPR-A) in L6-S1 Dorsal Root Ganglia in a Rat Model of Chronic Nonbacterial Prostatitis.
CONCLUSIONS In a rat model of CNP, the increased expression of BNP and NPR-A in L6-S1 DRG may have a role in pain signaling pathways associated with chronic prostatitis. PMID: 31777403 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - December 1, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Comparison of Inspiratory Effort, Workload and Cycling Synchronization Between Non-Invasive Proportional-Assist Ventilation and Pressure-Support Ventilation Using Different Models of Respiratory Mechanics.
CONCLUSIONS PAV with an appropriate combination of FA and VA decreases work of breathing during the inspiratory phase and improves simulator-ventilator cycling synchrony. FA has greater impact than VA in the adaptation to inspiratory effort demand. High VA level might help improve cycling synchrony. PMID: 31778366 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - December 1, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Berberine Inhibits Proliferative Ability of Breast Cancer Cells by Reducing Metadherin.
This study was performed to contribute to a better understanding on the mechanisms underlying berberine affecting breast cancer. MATERIAL AND METHODS We mined survival data of metadherin (MTDH) in breast cancer patients through Kaplan-Meier Plotter and analyzed the transcriptional and posttranscriptional expression profile of MTDH in several breast cancer cell lines. The cell viability and MTDH mRNA level were detected under the si-MTDH vector and different concentrations of berberine. The MTDH-expression vector was transfected into MCF-7 and MDA-MB-231 cells, and the changes of cell viability and apoptosis were determined...
Source: Medical Science Monitor - December 1, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Computed Tomography Perfusion Imaging Quality Affected by Different Input Arteries in Patients of Internal Carotid Artery Stenosis.
Authors: Chen X, Zou J, Bao L, Hu J, Ye G Abstract BACKGROUND The aim of this study was to explore the influence of different input arteries on the parameters of computed tomography (CT) perfusion imaging for patients with different degree of stenosis of internal carotid artery (ICA). MATERIAL AND METHODS Forty patients were enrolled in the present study and divided into mild, moderate, severe stenosis and occlusion groups respectively with each 10 patients in each group. In reconstruction of cerebral CT perfusion (CTP) images, each raw perfusion image was reconstructed 3 times based on different reference input ar...
Source: Medical Science Monitor - December 1, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Protective Effects of Dexmedetomidine and Oxycodone in Patients Undergoing Limb Ischemia-Reperfusion.
CONCLUSIONS Compared with Dex, Oxy was not inferior in mitigating tourniquet-induced hyperdynamic response, ameliorating the inflammatory reaction, and protecting remote multiple organs in lower-extremity surgery patients. PMID: 31782408 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - December 1, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Feasibility of Spontaneous Ventilation in Secondary Contralateral Thoracic Surgery.
Authors: Lan L, Jiang L, Zhang C, Qiu Y, Cen Y, He J Abstract BACKGROUND A secondary contralateral thoracic surgery is a challenging procedure and is rarely indicated. We retrospectively compared the perioperative values to find out whether video-assisted thoracoscopic surgery under spontaneous ventilation is feasible for this surgery. MATERIAL AND METHODS Patients were retrospectively collected from January 1, 2015 to December 30, 2018 who underwent secondary contralateral video-assisted thoracoscopic surgeries with mechanical ventilation (MV-VATS group) or spontaneous ventilation (SV-VATS group). A propensity sco...
Source: Medical Science Monitor - December 1, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Cavity Formation is a Prognostic Indicator for Pathologic Stage I Invasive Lung Adenocarcinoma of ≥3 cm in Size.
Cavity Formation is a Prognostic Indicator for Pathologic Stage I Invasive Lung Adenocarcinoma of ≥3 cm in Size. Med Sci Monit. 2019 Nov 27;25:9003-9011 Authors: Chen C, Fu S, Ni Q, Yiyang W, Pan X, Jing J, Zhao H, Rui W Abstract BACKGROUND We investigated the correlation between cavity formation, prognosis, and tumor stage for pathologic stage I invasive lung adenocarcinomas (IADCs) ≤3 cm in size. MATERIAL AND METHODS 2106 candidates with pathologic stage I IADC were identified from Shanghai Chest Hospital between 2009 and 2014. There were 227 patients who were diagnosed as having cavity formati...
Source: Medical Science Monitor - November 29, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Long Noncoding RNA loc285194 Expression in Human Papillomavirus-Positive and -Negative Cervical Squamous Cell Carcinoma, C33A, and SiHa Cells and Transforming Growth Factor- β1.
CONCLUSIONS The expression of lncRNA loc285194 inhibited the migration of CSCC cells in vitro through the inactivation of TGF-ß1. PMID: 31774069 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - November 29, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Plasma D-Dimer Level Is an Early Predictor of Severity of Acute Pancreatitis Based on 2012 Atlanta Classification.
CONCLUSIONS The average value of D-dimer levels could be used as a predictor of severity of AP. In general, patients with an average D-dimer level 7.268 would develop into SAP, and between 4.868 and 7.268 would be MSAP. PMID: 31774737 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - November 29, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Biochanin A Provides Neuroprotection Against Cerebral Ischemia/Reperfusion Injury by Nrf2-Mediated Inhibition of Oxidative Stress and Inflammation Signaling Pathway in Rats.
CONCLUSIONS The results indicated that biochanin A protected the brain against ischemic injury in rats by anti-oxidative and anti-inflammatory actions. The activation of the Nrf2 pathway and the inhibition of the NF-kappaB pathway may contribute to the neuroprotective effects of biochanin A. PMID: 31767824 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - November 28, 2019 Category: Research Tags: Med Sci Monit Source Type: research

C-Reactive Protein Levels and Survival Following Cytoreductive Nephrectomy in 118 Patients with Metastatic Renal Cell Carcinoma Treated with Sunitinib: A Retrospective Study.
This study aimed to evaluate the factors associated with a survival benefit for patients with metastatic renal cell carcinoma (mRCC) treated with sunitinib, with and without cytoreductive nephrectomy (CN). MATERIAL AND METHODS This retrospective clinical study included 118 patients with mRCC who were treated with CN and sunitinib (CN-sunitinib) (N=70) and with sunitinib-alone (N=48). Categorical clinicopathological variables were compared with hypothesis tests using contingency tables and a chi-squared test. Independent indicators for progression-free survival (PFS) and overall survival (OS) were analyzed with univariate a...
Source: Medical Science Monitor - November 28, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Inhibition of Nasopharyngeal Carcinoma by Beta-Lapachone Occurs by Targeting the Mammalian Target of Rapamycin (mTOR)/PI3K/AKT Pathway, Reactive Oxygen Species (ROS) Production, and Autophagy Induction.
CONCLUSIONS The findings of this study suggest that beta-lapachone inhibits the growth of nasopharyngeal cancer cells by promoting autophagy, and it may be useful in cancer drug discovery paradigms. PMID: 31770363 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - November 28, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Forkhead Box R2 Knockdown Decreases Chemoresistance to Cisplatin via MYC Pathway in Bladder Cancer.
CONCLUSIONS FoxR2 knockdown decreases chemoresistance to cisplatin via the MYC pathway in bladder cancer cells, and this may be a target for overcoming chemoresistance in bladder cancer. PMID: 31761897 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - November 27, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Publications on the Association Between Cognitive Function and Pain from 2000 to 2018: A Bibliometric Analysis Using CiteSpace.
CONCLUSIONS Bibliometric analysis of the association between pain and cognitive function might identify new directions for future research. PMID: 31762442 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - November 27, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Early Renal-Protective Effects of Remote Ischemic Preconditioning in Elderly Patients with Non-ST-Elevation Myocardial Infarction (NSTEMI).
CONCLUSIONS Although RIPC did not significantly reduce CIN incidence in elderly patients with NSTEMI, the application of more sensitive biomarkers - NGAL and KIM-1 - indicated a reduction of sub-clinical renal damage by RIPC, especially in the early stage of injury. As a simple and well-tolerated method, RIPC may be a potentially feasible option to prevent CIN. PMID: 31762443 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - November 27, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Prognostic Factors and Treatment Options for Patients with High-Grade Chondrosarcoma.
CONCLUSIONS Our study first demonstrated that adjuvant radiotherapy combined surgery could improve the survival of patients with undifferentiated myxoid and dedifferentiated chondrosarcoma. These results encourage the application of adjuvant radiotherapy for patients with high-grade chondrosarcoma and maximize the patients' outcome. PMID: 31765367 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - November 27, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Serum Metrnl Level is Correlated with Insulin Resistance, But Not with β-Cell Function in Type 2 Diabetics.
CONCLUSIONS Serum Metrnl level was associated with IR, but not with ß-cell function in participants with diagnosed type 2 diabetes. PMID: 31766048 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - November 27, 2019 Category: Research Tags: Med Sci Monit Source Type: research

The Anatomical Variation of the Scapular Spine in A Chinese Population.
CONCLUSIONS This study offered a comprehensive classification of SS in the Chinese population. On the whole, this study indicates that knowledge of the morphological variations of SS can prompt the diagnosis of scapular fractures and can promote more successful rTSA procedures, and the relative clinical trial is necessary to support it. PMID: 31757937 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - November 25, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Identification of Hub Genes Using Co-Expression Network Analysis in Breast Cancer as a Tool to Predict Different Stages.
CONCLUSIONS This study identified 49 hub genes that were associated with pathologic stage of breast cancer, 19 of which were significantly upregulated in breast cancer. Risk stratification, therapeutic decision making, and prognosis predication might be improved by our study results. This study provides new insights into biomarkers of breast cancer, which might influence the future direction of breast cancer research. PMID: 31758680 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - November 25, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Identification of Pivotal Genes and Pathways in Osteoarthritic Degenerative Meniscal Lesions via Bioinformatics Analysis of the GSE52042 Dataset.
CONCLUSIONS A series of pivotal genes and reactome pathways were identified elucidate the molecular mechanisms involved in the formation of osteoarthritic DMLs and to discover potential therapeutic targets. PMID: 31758856 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - November 25, 2019 Category: Research Tags: Med Sci Monit Source Type: research

SLK Triple Therapy Improves Maternal and Fetal Status and Promotes Postpartum Pelvic Floor Function in Chinese Primiparous Women.
This study investigated the effects of Sophrology childbirth-Kegel-Lamaze respiratory training (SLK triple therapy) on maternal and newborn health, pelvic floor function, and quality of life. MATERIAL AND METHODS Single-pregnant primiparous women involved in this study were divided into the control group (n=120) and the SLK triple therapy group (n=120). SLK triple therapy was taught to and practiced by the women in the SLK triple therapy group. Data on delivery mode (natural delivery or cesarean section), postpartum complications (postpartum urinary incontinence, postpartum hemorrhage), and birth process were recorded. Apg...
Source: Medical Science Monitor - November 25, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Napabucasin Attenuates Resistance of Breast Cancer Cells to Tamoxifen by Reducing Stem Cell-Like Properties.
CONCLUSIONS NP might be used as an adjuvant therapy for ER+ BC patients with TAM resistance. PMID: 31760402 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - November 25, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Diallyl Disulfide Mitigates DNA Damage and Spleen Tissue Effects After Irradiation.
CONCLUSIONS DADS is a potential radiation-protective agent that effectively mitigates DNA damage, and its effects in the spleen observed after irradiation may be related to inflammation and carcinogenesis. PMID: 31760404 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - November 25, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Strain Elastography-Targeted Biopsy: Does Prostate Volume Affect Prostate Cancer Detection?
Authors: Zhu YC, Shan J, Zhang Y, Jiang Q, Wang YB, Deng SH, Qu QH, Li Q Abstract BACKGROUND The present study aimed to assess the correlation between prostate volume and prostate cancer (PCa) detection by strain elastography (SE)-guided targeted biopsy (TB) compared with conventional transrectal ultrasound (TRUS)-guided systematic biopsy (SB). MATERIAL AND METHODS This retrospective study enrolled 357 patients suspected to have PCa. All patients received TRUS-guided 10-core SB and SE-guided TB. The sensitivity for PCa detected by SE-guided TB was compared with that by TRUS-guided SB, in combination with prostate b...
Source: Medical Science Monitor - November 24, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Effect of Eating Breakfast on Cognitive Development of Elementary and Middle School Students: An Empirical Study Using Large-Scale Provincial Survey Data.
CONCLUSIONS In primary school, students who eat breakfast every day in a week scored 31.322 points higher in academic performance than those who did not. In middle school, students who ate breakfast on time every day had significantly better academic performance (31.335 points higher) than those who did not eat breakfast every day. This indicates that eating breakfast every day has a significant effect on the cognitive development of students. PMID: 31755480 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - November 24, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Upregulation of Protease-Activated Receptor 2 Promotes Proliferation and Migration of Human Vascular Smooth Muscle Cells (VSMCs).
CONCLUSIONS PAR2 promotes cell proliferation and disrupts the quiescent condition of VSMCs, which may be a potential therapeutic target for atherosclerosis. PMID: 31756174 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - November 24, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Zafirlukast, a Cysteinyl Leukotriene Receptor 1 Antagonist, Reduces the Effect of Advanced Glycation End-Products in Rat Renal Mesangial Cells In Vitro.
CONCLUSIONS Zafirlukast, a CysLTR1 antagonist, reduced the levels of inflammatory cytokines, markers of oxidative stress, and cell apoptosis induced by AGE in mesangial cells in a dose-dependent way. Future in vivo studies are needed to investigate the potential role for zafirlukast in models of diabetic nephropathy. PMID: 31745068 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - November 22, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Epidermal Growth Factor Receptor Mutations in Resectable Non-Small Cell Lung Cancer Patients and their Potential Role in the Immune Landscape.
In this study, we investigated genetic variations in EGFR and their association with the clinical and pathological factors of NSCLC. MATERIAL AND METHODS Clinical cases (331 patients) and The Cancer Genome Atlas (TCGA) cases (1040 patients) were selected and analyzed using the refractory mutation systems cBioPortal and the Tumor Immune Estimation Resource (TIMER). RESULTS EGFR mutation frequencies were 54.4% (180 of 331 patients) and 8.0% (83 of 1040 patients) in the clinical and TCGA cohorts, respectively. EGFR mutations were strongly associated with smoking and pathology (P≤0.05) in the clinical cohort, and with gende...
Source: Medical Science Monitor - November 22, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Identification of Potentially Functional CircRNA-miRNA-mRNA Regulatory Network in Gastric Carcinoma using Bioinformatics Analysis.
CONCLUSIONS This study looked at a circRNA-miRNA-mRNA regulatory network associated with GC and explored the potential functions of mRNA in the network, then identified a new molecular marker for prediction, prognosis, and therapeutic targets for clinical patients. PMID: 31747387 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - November 22, 2019 Category: Research Tags: Med Sci Monit Source Type: research

PTEN-Induced Putative Kinase 1 (PINK1)/Parkin-Mediated Mitophagy Protects PC12 Cells Against Cisplatin-Induced Neurotoxicity.
CONCLUSIONS PINK1/Parkin-regulated mitophagy can protect against cisplatin-related neurotoxicity, suggesting therapeutic enhancement of mitophagy as a potential intervention for cisplatin-induced peripheral neuropathies. The interference of cisplatin with autophagosome-lysosome fusion may be partly responsible for cisplatin-induced neurotoxicity. PMID: 31748499 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - November 22, 2019 Category: Research Tags: Med Sci Monit Source Type: research