Exosomes Mediated Transfer of Circ_UBE2D2 Enhances the Resistance of Breast Cancer to Tamoxifen by Binding to MiR-200a-3p.
CONCLUSIONS Exosomes mediated transfer of circ_UBE2D2 reinforced tamoxifen resistance in breast cancer by binding to miR-200a-3p, providing new insights into the boost of the effectiveness of tamoxifen on breast cancer patients. PMID: 32756532 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 13, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Integrated Analysis of Hub Genes and Pathways In Esophageal Carcinoma Based on NCBI's Gene Expression Omnibus (GEO) Database: A Bioinformatics Analysis.
CONCLUSIONS The signaling pathways involving the DEGs probably represent the pathological mechanism underlying ESCA. The hub genes were associated with survival of ESCA patients, and as such have the potential to serve as diagnostic indicators and therapeutic targets. PMID: 32756534 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 13, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Cyclin-Dependent Kinase 1 (CDK1) is Co-Expressed with CDCA5: Their Functions in Gastric Cancer Cell Line MGC-803.
CONCLUSIONS Co-expression of CDK1 and CDCA5 might confer cell proliferation, migration, and invasion abilities in GC cells, and this can provide some clues for further therapies of gastric tumors. PMID: 32759885 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 13, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Extracorporeal Membrane Oxygenation (ECMO) in Critically Ill Patients with Coronavirus Disease 2019 (COVID-19) Pneumonia and Acute Respiratory Distress Syndrome (ARDS).
This article reviews the pertinent clinical literature, technical guidance, and expert recommendations on use of ECMO in critically ill cases of COVID-19. Here, we present basic knowledge and opinions about COVID-19 and ECMO, review the evidence on ECMO use in Middle East Respiratory Syndrome (MERS) and H1N1 influenza, share the technical guidance and recommendations on use of ECMO in COVID-19, summarize the current use of ECMO against COVID-19 in China, and discuss the issues in use of ECMO in COVID-19. PMID: 32759887 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 13, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Elevated Lateral Position Improves the Success of Paramedian Approach Subarachnoid Puncture in Spinal Anesthesia before Hip Fracture Surgery in Elderly Patients: A Randomized Controlled Study.
Authors: Zhang W, Wang T, Wang G, Yuan Y, Zhou Y, Yang X, Yang M, Zheng S Abstract BACKGROUND The aim of this study was to determine whether an elevated lateral recumbent position, compared to regular lateral recumbent position, may reduce the number of needle passes and attempts required for success subarachnoid puncture in spinal aesthesia before surgery in elderly patients with hip fractures. MATERIAL AND METHODS This was a randomized controlled interventional study in Beijing Jishuitan Hospital. Patients older than 65 years of age with hip fracture orthopedics who were planned to receive subarachnoid block in t...
Source: Medical Science Monitor - August 13, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Reelin Promotes Cisplatin Resistance by Induction of Epithelial-Mesenchymal Transition via p38/GSK3 β/Snail Signaling in Non-Small Cell Lung Cancer.
CONCLUSIONS These data indicated that Reelin induces DDP resistance of NSCLC by regulation of the p38/GSK3ß/Snail/EMT signaling pathway and provide evidence that Reelin suppression can be an effective strategy to suppress DDP resistance in NSCLC. PMID: 32764530 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 13, 2020 Category: Research Tags: Med Sci Monit Source Type: research

The Release of Norepinephrine in C57BL/6J Mice Treated with 6-Hydroxydopamine (6-OHDA) is Associated with Translocations in Enteric Escherichia coli via the QseC Histidine Kinase Receptor.
CONCLUSIONS NE modulates the interaction of enteric bacterial pathogens with their hosts via QseC. The blockade of the QseC receptor-mediated effects may be useful to attenuate bacterial translocation. PMID: 32764532 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 13, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Risk Factors for Severe Complications After Laparoscopic Surgery for T3 or T4 Rectal Cancer for Chinese Patients: Experience from a Single Center.
CONCLUSIONS Preoperative high white blood cells, diabetes mellitus and pulmonary dysfunction were independent risk factors for severe complications after laparoscopic surgery for T3 or T4 rectal cancer. PMID: 32764534 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 13, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Value of Combination of Heart, Lung, and Diaphragm Ultrasound in Predicting Weaning Outcome of Mechanical Ventilation.
Authors: Xu X, Wu R, Zhang YJ, Li HW, He XH, Wang SM Abstract BACKGROUND Postextubation distress is detrimental to the prognosis of critically ill patients with successful spontaneous breathing trial. The known risk factors of failed weaning are associated with the heart, lungs, and diaphragm. The aim of this study was to explore the role of a combined model including indicators of heart, lung, and diaphragm ultrasound in predicting the weaning outcome. MATERIAL AND METHODS Patients' clinical data and ultrasonic features of heart, lungs, and diaphragm were recorded. Patients were included in either the failed weani...
Source: Medical Science Monitor - August 13, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Systematic Understanding of Mechanism of Yi-Qi-Huo-Xue Decoction Against Intracerebral Hemorrhagic Stroke Using a Network Pharmacology Approach.
CONCLUSIONS The present results may serve as a pharmacological framework for TCM studies in the future, helping to promote the use of YQHXD in clinical treatment of ICH. PMID: 32769962 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 13, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Protective Effect of Probiotics against Esophagogastric Variceal Rebleeding in Patients with Liver Cirrhosis after Endoscopic Therapy.
Authors: Zhang Q, Gao F, Yang X, Hu Y, Liu Y, Hou Y, Li Y, Zhu B, Niu S, Huang Y, Wang X Abstract BACKGROUND Probiotic therapy has been shown to be beneficial against some liver diseases. However, there is still uncertainty regarding the clinical efficacy of probiotics for the treatment of variceal rebleeding. This research explored the efficacy of probiotics in variceal rebleeding. MATERIAL AND METHODS This was a retrospective study of 704 consecutive patients with liver cirrhosis who recovered from esophagogastric variceal bleeding after endoscopic treatment. Patients were subdivided into a probiotics cohort (n=2...
Source: Medical Science Monitor - August 13, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Long Non-Coding RNA SNHG8 Plays a Key Role in Myocardial Infarction Through Affecting Hypoxia-Induced Cardiomyocyte Injury.
CONCLUSIONS We demonstrated that lncRNA SNHG8 affected myocardial infarction by affecting hypoxia-induced cardiomyocyte injury via regulation of the NF-kappaB pathway. PMID: 32772038 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 13, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Dishevelled Associated Activator Of Morphogenesis (DAAM) Facilitates Invasion of Hepatocellular Carcinoma by Upregulating Hypoxia-Inducible Factor 1 α (HIF-1α) Expression.
CONCLUSIONS DAAM2, rather than DAAM1, was able to predict prognosis of HCC. DAAM2 decreased VHL expression and consequently upregulated HIF-1alpha, eventually facilitating invasion of HCC. PMID: 32772041 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 13, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Locking Plates versus Locking Intramedullary Nails Fixation of Proximal Humeral Fractures Involving the Humeral Shaft: A Retrospective Cohort Study.
Authors: Song H, He T, Guo HY, Li ZY, Wei M, Zhang C, Dong YQ Abstract BACKGROUND For proximal humeral fractures (PHFs), locking intramedullary nails and locking plates have been widely used. However, few reports have been published on the therapy of complex PHFs accompanying humeral shaft fractures. Therefore, we performed this research to analyze the effectiveness of locking intramedullary nails and locking plates in the management of proximal humeral fractures involving the humeral shaft. MATERIAL AND METHODS We retrospectively reviewed 40 cases diagnosed with proximal humeral fractures involving the humeral sha...
Source: Medical Science Monitor - August 13, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Abnormal Fractional Amplitude of Low-Frequency Fluctuation Changes in Patients with Monocular Blindness: A Functional Magnetic Resonance Imaging (MRI) Study.
Authors: Fang JW, Yu YJ, Tang LY, Chen SY, Zhang MY, Sun T, Wu SN, Yu K, Li B, Shao Y Abstract BACKGROUND We used fractional amplitude of low-frequency fluctuation (fALFF) technology to investigate spontaneous cerebral activity in patients with monocular blindness (MB) and in healthy controls (HCs). MATERIAL AND METHODS Thirty MB patient and 15 HCs were included in this study. All subjects were scanned by resting-state functional magnetic resonance imaging (rs-fMRI). The independent sample t test and chi-squared test were applied to analyze demographics of MB patients and HCs. The 2-sample t test and receiver opera...
Source: Medical Science Monitor - August 13, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Preparation and Characterization of a Novel Triple Composite Scaffold Containing Silk Fiborin, Chitosan, and Alginate for 3D Culture of Colonic Carcinoma Cells In Vitro.
CONCLUSIONS This study successfully demonstrated the potential of SF/Cs/Alg (1: 1: 1) scaffold as an alternative for the 3D in vitro culture of CC cells. PMID: 32773734 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 13, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Silencing of Long Non-Coding RNA (lncRNA) Nuclear Paraspeckle Assembly Transcript 1 (NEAT1) Protects PC-12 Cells from LPS-Induced Injury via Targeting miR-29a.
CONCLUSIONS High NEAT1 levels can increase LPS-induced injury in PC-12 cells through the miR-29a/BCL2L11 pathway. lncRNA NEAT1 may, therefore, be a promising target for SCI treatment. PMID: 32776916 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 13, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Early Death Incidence and Prediction in Stage IV Breast Cancer.
CONCLUSIONS Nomograms were generated to predict early death, with good calibration and discrimination. The predictive model can provide a reference for identifying cases with high risk of early death among stage IV breast cancer patients and play an auxiliary role in guiding individual treatment. PMID: 32778637 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 13, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Fiber Type-Specific Morphological and Cellular Changes of Paraspinal Muscles in Patients with Severe Adolescent Idiopathic Scoliosis.
CONCLUSIONS The fiber type-specific pathological changes on the concave side seemed to be more severe. Some fiber type-specific characteristics (CSA, myonuclei density, total/activated SC density) were closely associated with curve severity. More attention should be paid to PSM physiotherapy treatment on the concave side. PMID: 32778639 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 13, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Silencing of Long Non-Coding RNA (LncRNA) Non-Coding RNA Activated by DNA Damage (NORAD) Inhibits Proliferation, Invasion, Migration, and Promotes Apoptosis of Glioma Cells via Downregulating the Expression of AKR1B1.
CONCLUSIONS These findings demonstrated that NORAD silencing suppressed proliferation, invasion, and migration and boosted apoptosis of glioma cells via downregulating the AKR1B1 expression, which may provide a potential therapeutic target for glioma treatment. PMID: 32778640 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 13, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Current Status of Research on the Role of Circular RNAs in Hepatocellular Carcinoma and Clinical Implications.
Authors: Zou RC, Li LL, Yuan HL Abstract The latest statistics show that rates of morbidity and mortality for hepatocellular carcinoma are gradually increasing over time. Accumulating evidence indicates that circular RNAs (circRNAs) participate in the regulation of gene transcription and translation and exert a crucial role in endogenous RNA network. circRNAs are implicated in the pathogenesis of numerous tumors including hepatocellular carcinoma (HCC), gastric carcinoma and bladder cancer. Of note, the effect of circRNAs in HCC has drawn increasing public attention. Previous studies revealed that the function of c...
Source: Medical Science Monitor - August 13, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Nkx2-5 Regulates the Proliferation and Migration of H9c2 Cells.
CONCLUSIONS Nkx2-5 may regulate proliferation and migration of the H9c2 cells through the genes Tgfb-2, Bmp10, Id2, Wt1, Hey1, and Cacna1g; rno-miR-1-3p; the TGF‑ß signaling pathway; the MAPK signaling pathway; as well as other genes and pathways. PMID: 32780729 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 13, 2020 Category: Research Tags: Med Sci Monit Source Type: research

A Regulatory Axis of circ_0008193/miR-1180-3p/TRIM62 Suppresses Proliferation, Migration, Invasion, and Warburg Effect in Lung Adenocarcinoma Cells Under Hypoxia.
CONCLUSIONS Upregulating circ_0008193 inhibited LUAD cell proliferation, migration, invasion, and Warburg effect under hypoxia in vitro and in vivo through regulation of the miR-1180-3p/TRIM62 axis. PMID: 32782238 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 13, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Retinoic Acid-Platinum (II) Complex [RT-Pt(II)] Protects Against Rheumatoid Arthritis in Mice via MEK/Nuclear Factor kappa B (NF- κB) Pathway Downregulation.
CONCLUSIONS In summary, the present study demonstrated that RT-Pt(II) inhibits TNF-alpha-induced inflammatory response, suppresses cell viability, and induces apoptosis in rheumatoid arthritis synovial cells. Moreover, RT-Pt(II) exhibited its effect through targeting the MEK/NF-kappaB pathway. Therefore, RT-Pt(II) can be used for the development of treatments for rheumatoid arthritis. PMID: 32741960 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 5, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Galectins for Diagnosis and Prognostic Assessment of Human Diseases: An Overview of Meta-Analyses.
Authors: Liu Y, Meng H, Xu S, Qi X Abstract An increasing number of studies have explored the activities and functions of galectins. However, translation of these researches into clinical practice seems to be lacking. As compared to scattered individual studies, meta-analyses can provide a more comprehensive review of current evidence and reach a more unbiased and powered conclusion by synthesizing data from diverse studies. In this paper, findings from meta-analyses were reviewed to establish the role of galectins in diagnosis and prognostic assessment of various human diseases. First, in patients with cancer, gal...
Source: Medical Science Monitor - August 5, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Effects of Contrast Therapy Using Infrared and Cryotherapy as Compared with Contrast Bath Therapy on Blood Flow, Muscle Tone, and Pain Threshold in Young Healthy Adults.
Authors: Kim J, Jung H, Yim J Abstract BACKGROUND The aim of this research was to compare the effects of contrast bath therapy (CBT) and contrast therapy (CT) using infrared (IR) and cryotherapy (CR) on blood flow, muscle tone, and pain in the forearm. MATERIAL AND METHODS Twenty healthy individuals participated in this study. Each participant received 2 kinds of CT separated by a week. CBT involved immersion in hot water (38-40°C) for 4 minutes, followed by 1 minute of immersion in cold water (12-14°C) for four rotations. CT using IR and CR was performed in the same manner as CBT. RESULTS The variables mea...
Source: Medical Science Monitor - August 5, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Sirtuin 3 mRNA Expression is Downregulated in the Brain Tissues of Alzheimer's Disease Patients: A Bioinformatic and Data Mining Approach.
CONCLUSIONS SIRT3 mRNA is downregulated in the brain tissues of AD patients, promoting the progression of AD. PMID: 32747616 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 5, 2020 Category: Research Tags: Med Sci Monit Source Type: research

TPX2 Promotes Metastasis and Serves as a Marker of Poor Prognosis in Non-Small Cell Lung Cancer.
CONCLUSIONS This study demonstrated that TPX2 promotes the metastasis and malignant progression of NSCLC and could thus serve as a marker of poor prognosis in NSCLC. PMID: 32748897 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 5, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Role and Mechanism of Maresin-1 in Acute Lung Injury Induced by Trauma-Hemorrhagic Shock.
CONCLUSIONS Our study showed that MaR1 could effectively alleviated THS-induced lung injury via inhibiting the excitation of the TLR4/p38MAPK/NF-kappaB pathway in THS-induced rats, suggesting that MaR1 might be a novel agent for lung damage treatment. PMID: 32750045 [PubMed - as supplied by publisher] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 5, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Prognostic Implications of Novel Gene Signatures in Gastric Cancer Microenvironment.
CONCLUSIONS In general, this study constructs a prognostic risk assessment model for gastric cancer, which could improve the prognosis stratification of patients combined with other clinical indicators. PMID: 32740646 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 4, 2020 Category: Research Tags: Med Sci Monit Source Type: research

The Potential Protective Role of Aspirin Against Migraine in Pregnant Women.
Authors: Liu X, Gong Y Abstract Females are highly predisposed to the occurrence of migraine, a recurrent neurovascular headache disorder. Although migraine improves or disappears during pregnancy, a significant association between migraine and hypertension (i.e., pre-eclampsia) or vascular complications (i.e., stroke) during gestation has been determined. Low-dose aspirin exerts an antithrombotic effect and can improve vascular resistance by regulating endothelial function, which are implicated in the pathogenesis of migraine, pre-eclampsia, and other vascular complications during pregnancy. Low-dose aspirin is wi...
Source: Medical Science Monitor - August 4, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Identification of Differentially Expressed Proteins in Serum of Obese Patients by Isobaric Tags for Relative and Absolute Quantification (iTRAQ)-Coupled 2D LC-MS.
CONCLUSIONS iTRAQ is an effective technique to identify differentially expressed proteins in obese patients. The development of obesity is correlated with a series of complex elements and mutual effects. The proteins identified in this study may provide novel directions and targets for future pathological studies of obesity. PMID: 32740648 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 4, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Peripheral Absolute Lymphocyte Count: An Economical and Clinical Available Immune-Related Prognostic Marker for Newly Diagnosed Multiple Myeloma.
CONCLUSIONS ALC and LMR can serve as surrogate markers for patients' antitumor immunity at the initial diagnosis of multiple myeloma. A new immune-related staging system, L-ISS, which combines ALC and the ISS staging system, can predict clinical outcomes in patients who are receiving bortezomib-based chemotherapy. PMID: 32732863 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 2, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Curcumin Derivative C086 Combined with Cisplatin Inhibits Proliferation of Osteosarcoma Cells.
CONCLUSIONS The current results demonstrate that combined treatment with cur C086+cisplatin may be an effective form of chemotherapy for patients with osteosarcoma. PMID: 32734935 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 2, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Identification of Prognostic Biomarkers Associated with Cancer Stem Cell Features in Prostate Adenocarcinoma.
CONCLUSIONS Our data demonstrate the mRNAsi as a reliable index for the tumorigenesis, PSA value, and Gleason score of PRAD. Additionally, this study provides a well-applied model for predicting the OS for patients with PRAD based on prognostic SRGs. PMID: 32735556 [PubMed - as supplied by publisher] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 2, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Effects of Occupational Stress and Circadian CLOCK Gene Polymorphism on Sleep Quality of Oil Workers in Xinjiang, China.
This study investigated the effect of occupational stress and circadian clock gene polymorphism on sleep disorder of oil workers in Xinjiang, China. MATERIAL AND METHODS We enrolled 2300 Xinjiang oil workers who had been working for at least 1 year. The Chinese revised version of the Occupational Stress Questionnaire (OSI-R), the Pittsburgh Sleep Quality Index (PSQI), and General Survey Questionnaire were used. A total of 308 subjects were selected for stress hormone measurements and gene polymorphism analysis of the circadian clock genes CLOCK, PER2, and PER3. RESULTS The occupational stress scores were influenced by sex,...
Source: Medical Science Monitor - August 2, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Streptococcus bovis Contributes to the Development of Colorectal Cancer via Recruiting CD11b ⁺TLR-4⁺ Cells.
This study aimed to explore the role of S. bovis in carcinogenesis and its potential mechanism in CRC of mice orally pretreated with S. bovis. MATERIAL AND METHODS The colons of experimental mice were collected and evaluated for the extent of neoplasm. In addition, comparative feces DNA sequencing was adopted to verify the abundance change of S. bovis during the progression of CRC in patients. RESULTS The results of this study found that S. bovis is more likely to be present at higher levels in patients with progressive colorectal carcinoma compared to those adenoma patients and healthy volunteers (P
Source: Medical Science Monitor - August 2, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Effects of Jian-Pi-Zhi-Dong Decoction on the Expression of 5-HT and Its Receptor in a Rat Model of Tourette Syndrome and Comorbid Anxiety.
CONCLUSIONS JPZDD alleviated both tic and anxiety symptoms and the mechanism may be via reducing the expression of 5-HT2C mRNA in the striatum, increasing the concentration of 5-HT, and enhancing the activity of the 5-HT system, which in turn exerts neuro-inhibition. PMID: 32738135 [PubMed - as supplied by publisher] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 2, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Identification and Expression of Several Circular RNAs and Knockdown of hsa_circ_0005556 Exerts Oncogenic Functions by miR-767-5p in Gastric Cancer.
CONCLUSIONS The in vitro knockdown of circ_0005556 remarkably repressed GC cell progression by increasing the expression of miR-767-5p. PMID: 32728015 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 1, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Outcomes of VA-ECMO with and without Left Centricular (LV) Decompression Using Intra-Aortic Balloon Pumping (IABP) versus Other LV Decompression Techniques: A Systematic Review and Meta-Analysis.
Authors: Pan P, Yan P, Liu D, Wang X, Zhou X, Long Y, Xiao K, Zhao W, Xie L, Su L Abstract BACKGROUND Left ventricular decompression is the primary method for solving VA-ECMO-induced LV afterload increase, but the effect of specific methods on patient outcomes and complications is unknown. MATERIAL AND METHODS We searched for all published reports conducted in patients undergoing ECMO combined with LVD. Statistical analyses were performed using Stata 12.0. RESULTS The results showed that the risk of death with ECMO combined with LVD was 29% lower than that with ECMO alone (OR=0.71, 95% CI: 0.56-0.89, I²=59.5%, P
Source: Medical Science Monitor - August 1, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Reliability of Myotonometric Measurement of Stiffness in Patients with Spinal Cord Injury.
CONCLUSIONS Our findings suggest that use of the MyotonPRO is feasible for evaluating stiffness of the gastrocnemius and AT in the lower limbs of patients with spinal cord injury. PMID: 32719308 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - July 30, 2020 Category: Research Tags: Med Sci Monit Source Type: research

A Comparison of Clinical Characteristics and Outcomes in Elderly and Younger Patients with COVID-19.
Authors: Song J, Hu W, Yu Y, Shen X, Wang Y, Yan J, Yang X, Gong S, Wang M Abstract BACKGROUND The aim of this study was to describe the clinical characteristics and outcomes of patients with coronavirus disease 2019 (COVID-19) and compare these parameters in an elderly group with those in a younger group. MATERIAL AND METHODS This retrospective, single-center observational study included 69 hospitalized patients with laboratory-confirmed COVID-19 from a tertiary hospital in Wuhan, China, between January 14, 2020, and February 26, 2020. Epidemiological, demographic, clinical, and laboratory data, as well as treatme...
Source: Medical Science Monitor - July 30, 2020 Category: Research Tags: Med Sci Monit Source Type: research

CircKIAA0907 Retards Cell Growth, Cell Cycle, and Autophagy of Gastric Cancer In Vitro and Inhibits Tumorigenesis In Vivo via the miR-452-5p/KAT6B Axis.
CONCLUSIONS This work demonstrated that circKIAA0907 has diagnostic and therapeutic value in GC by acting as an oncogenic molecule via the miR-452-5p/KAT6B axis. PMID: 32722658 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - July 30, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Pediatric Trigger Thumb with Metacarpophalangeal Joint Hyperextension or Instability.
CONCLUSIONS Trigger thumb with MCPH and MCPI in children is significantly associated with multi-joint laxity. While there was still MCPH after cast treatment, there was no need for further treatment during the short-term follow-up. Cast and brace treatment after surgery was a simple, easy method for treatment of MCPI and had a good effect. PMID: 32724026 [PubMed - as supplied by publisher] (Source: Medical Science Monitor)
Source: Medical Science Monitor - July 30, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Long Non-Coding RNA Nuclear Paraspeckle Assembly Transcript 1 (NEAT1)Relieves Sepsis-Induced Kidney Injury and Lipopolysaccharide (LPS)-Induced Inflammation in HK-2 Cells.
CONCLUSIONS Our data show that the lower expression of NEAT1 impeded sepsis development and LPS-induced injury inflammation by targeting let-7b-5p/TRAF6 axis, and NEAT1 may be a target for treatment of sepsis patients. PMID: 32724027 [PubMed - as supplied by publisher] (Source: Medical Science Monitor)
Source: Medical Science Monitor - July 30, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Analysis of Cervical Sagittal Balance in Treating Cervical Spondylotic Myelopathy: 1-Level Anterior Cervical Corpectomy and Fusion Versus 2-Level Anterior Cervical Discectomy and Fusion.
CONCLUSIONS Anterior cervical surgery may change the sagittal balance in terms of T1S or Cobb angle. No significant difference was found between ACCF and ACDF in clinical outcomes or representative global sagittal parameters. ACDF achieved more lordosis improvement than ACCF, with higher T1S. Surgeons need to pay extra attention to cervical sagittal balance, rather than focusing solely on decompression. PMID: 32726302 [PubMed - as supplied by publisher] (Source: Medical Science Monitor)
Source: Medical Science Monitor - July 30, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Efficient Picosecond Laser for Tattoo Removal in Rat Models.
CONCLUSIONS We leveraged the evaluation standard to choose the most suitable energy value of the picosecond laser, which had a good tattoo removal effect and could be employed as a reference for clinical removal of tattoos. This process provides criteria for tattoo removal evaluations as well as alternatives for tattoo removal in clinical practice. PMID: 32709839 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - July 29, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Factors Influencing Anxiety of Health Care Workers in the Radiology Department with High Exposure Risk to COVID-19.
CONCLUSIONS Our study suggests that the anxiety level of health care workers in the radiology department with a high exposure risk to COVID-19 was high in the early stage of the outbreak, although the majority remained within normal limits. Timely assessment and effective intervention measures can improve the mental health of these at-risk populations. PMID: 32710536 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - July 29, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Competing-Risks Model for Predicting the Postoperative Prognosis of Patients with Papillary Thyroid Adenocarcinoma Based on The Surveillance, Epidemiology, and End Results (SEER) Database.
Authors: Bian F, Li C, Han D, Xu F, Lyu J Abstract BACKGROUND The aim of this study was to identify accurate prognostic factors for postoperative papillary thyroid adenocarcinoma (PTAC) using a competing-risks model based on data from the Surveillance, Epidemiology, and End Results (SEER) database. MATERIAL AND METHODS Data on patients with PTAC who had received surgery between 2010 and 2015 in the SEER database were extracted. A univariate analysis was performed while considering competing risks using the cumulative incidence function, with Nelson-Aalen cumulative risk curves of the incidence function for PTAC-spe...
Source: Medical Science Monitor - July 29, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Integrated Analysis of Three Publicly Available Gene Expression Profiles Identified Genes and Pathways Associated with Clear Cell Renal Cell Carcinoma.
CONCLUSIONS Cell cycle and focal adhesion were dysregulated in ccRCC, which were associated with the expression of CCND2, ITGB4, KDR, and CCNA2 genes. The deregulation of pathways and associated genes may provide insights to ccRCC research and therapy. PMID: 32712616 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - July 29, 2020 Category: Research Tags: Med Sci Monit Source Type: research