Anti-Proliferative Effect of Wogonin on Ovary Cancer Cells Involves Activation of Apoptosis and Cell Cycle Arrest.
CONCLUSIONS In summary, this study demonstrated that wogonin acts as an ovary cancer cell proliferation inhibiting agent through activation of apoptosis. Wogonin, therefore, can be investigated further for the development of ovary cancer treatment. PMID: 31707402 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - November 12, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Elevated Uric Acid Levels Promote Vascular Smooth Muscle Cells (VSMC) Proliferation via an Nod-Like Receptor Protein 3 (NLRP3)-Inflammasome-Dependent Mechanism.
CONCLUSIONS Our findings revealed that uric acid induces inflammation through NLRP3-inflammasome-mediated VSMC proliferation. NLRP3 may be a new therapeutic target for hypertension. PMID: 31707403 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - November 12, 2019 Category: Research Tags: Med Sci Monit Source Type: research

A Retrospective Case-Control Study on the Chest Wall and Lung Characteristics in Patients with Primary Spontaneous Pneumothorax.
Authors: Huang H, Peng X, Zhang H, Li W, Wang C Abstract BACKGROUND Primary spontaneous pneumothorax (PSP) is reported to be more common in young men who are thin and tall. This retrospective study aimed to analyze the clinical and chest wall characteristics associated with PSP. MATERIAL AND METHODS Between January 2008 to December 2017, the clinical and imaging data of 99 patients at first presentation with PSP were compared with 82 age-matched healthy controls. Computed tomography (CT) imaging was used to measure the anteroposterior and transverse diameters of the chest at four levels, including the aortic arch, ...
Source: Medical Science Monitor - November 12, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Comprehensive Study of Surgical Treated Lung Adenocarcinoma with Ground Glass Nodule Component.
Authors: Xu Y, Zheng M, Wang N, Wang R Abstract BACKGROUND More and more patients with lung adenocarcinoma were detected with ground glass nodule (GGN) due to the popularity of low-dose spiral computed tomography (LDCT) recently. The clinicopathological characteristics and epidermal growth factor receptor (EGFR) mutation features were unclear. MATERIAL AND METHODS This retrospective study enrolled patients with surgical resected primary lung adenocarcinomas with GGN component. The clinicopathological data included age, gender, smoking history, tumor staging, lymph node staging, surgical methods, subtypes, thyroid t...
Source: Medical Science Monitor - November 12, 2019 Category: Research Tags: Med Sci Monit Source Type: research

MicroRNA-27a-3p Downregulation Inhibits Inflammatory Response and Hippocampal Neuronal Cell Apoptosis by Upregulating Mitogen-Activated Protein Kinase 4 (MAP2K4) Expression in Epilepsy: In Vivo and In Vitro Studies.
CONCLUSIONS Our preliminary findings indicated that miR-27a-3p inhibitor protected against epilepsy-induced inflammatory response and hippocampal neuronal apoptosis by targeting MAP2K4. PMID: 31710596 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - November 12, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Role of Long Non-Coding RNA (LncRNA) LINC-PINT Downregulation in Cardiomyopathy and Retinopathy Progression Among Patients with Type 2 Diabetes.
CONCLUSIONS Hence, we concluded that the overexpression of LINC-PINT may exhibit inhibitory effects on the progression of cardiomyopathy and retinopathy among patients with type 2 diabetes. PMID: 31711064 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - November 12, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Identification of Hub Genes and Pathways in a Rat Model of Renal Ischemia-Reperfusion Injury Using Bioinformatics Analysis of the Gene Expression Omnibus (GEO) Dataset and Integration of Gene Expression Profiles.
CONCLUSIONS In a rat model of renal IRI, bioinformatics analysis of the GEO dataset and integration of gene expression profiles identified involvement of HIF-1alpha signaling and the STAT3 hub gene. PMID: 31699960 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - November 9, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Inhibitory Effect of Sirtuin6 (SIRT6) on Osteogenic Differentiation of Bone Marrow Mesenchymal Stem Cells.
CONCLUSIONS The SIRT6-TRPV1-CGRP signal axis is the key to regulating OD in hMSCs, which could be a potential therapeutic target for osteoporosis and bone loss-related diseases. PMID: 31701920 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - November 9, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Foot Deformities in Women Are Associated with Wearing High-Heeled Shoes.
CONCLUSIONS The feet of women wearing high-heeled shoes were significantly flatter transversely, with a more laterally flexed hallux, as compared to those wearing low-heeled or flat-soled shoes. Wearing high-heeled shoes was associated with higher incidence of hallux valgus. The incidence of varus deformity of the fifth toe was associated with wearing high-heeled shoes. PMID: 31701921 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - November 9, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Overexpression of Tripartite Motif-Containing 48 (TRIM48) Inhibits Growth of Human Glioblastoma Cells by Suppressing Extracellular Signal Regulated Kinase 1/2 (ERK1/2) Pathway.
CONCLUSIONS TRIM48 suppressed the growth of human GBM cell via the prevention of ERK1/2 activation. PMID: 31703057 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - November 9, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Long Noncoding RNA VIM Antisense RNA 1 (VIM-AS1) Plays an Important Role in Development of Preeclampsia by Regulation of Epithelial Mesenchymal Transition.
This study aimed to evaluate the effects and mechanism of VIM antisense RNA 1 (VIM-AS1) in the development of preeclampsia. MATERIAL AND METHODS HTR-8/SVneo cells were divided into normal control (NC), Model, Blank, and VIM-AS1 groups. These groups were analyzed for their VIM-AS1 gene expressions by RT-PCR, HTR-8/SVneo cell invasion was assessed by transwell and migration by wound healing, cell morphology was assessed by microscopy examination, and E-cadherin, Snail, and Vimentin genes expressions were assessed by RT-PCR and WB assay. RESULTS VIM-AS1 gene expression was significantly different among normal placenta tissue,...
Source: Medical Science Monitor - November 8, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Evidence from 40 Studies that 2 Common Single-Nucleotide Polymorphisms (SNPs) of RNASEL Gene Affect Prostate Cancer Susceptibility: A Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA)-Compliant Meta-Analysis.
CONCLUSIONS We report the effect of rs627928 on the development of prostate cancer and confirm that rs486907 is not involved in the risk of prostate cancer in the current meta-analysis. However, research in larger populations is needed to validate our conclusions. PMID: 31686670 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - November 8, 2019 Category: Research Tags: Med Sci Monit Source Type: research

ENST00000489707.5 Is a Preferred Alternative Splicing Variant of PTK7 in Adrenocortical Cancer and Shows Potential Prognostic Value.
CONCLUSIONS ENST00000489707.5 is a preferred alternative splicing product of PTK7, with a significantly increased proportion in ACC compared with other cancers. Its expression shows potential prognostic value in terms of PFS and DSS in ACC patients. The methylation status of cg20819617 might play a critical role in modulating PTK7 transcription and ENST00000489707.5 expression. PMID: 31689287 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - November 8, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Inhibitive Effects of Huashi Pill on Formation of Renal Stones by Modulating Urine Biochemical Indexes and Osteopontin in Renal Stone Rat Models.
This study aimed to the investigate the therapeutic effects of Huashi Pill on clearance of renal stones. MATERIAL AND METHODS Sprague Dawley rats were divided into normal control, positive control, low-dosage Huashi Pill, medium-dosage Huashi Pill, and high-dosage Huashi Pill groups. A renal rat model was established by using ethylene glycol, ammonium chloride, and calcium gluconate. The urinary pH, urine protein, and uric acid levels, as well as the calcium, magnesium, and phosphorus levels were examined. The blood urea nitrogen (BUN) and creatinine (Cr) levels were also evaluated. Aspartate aminotransferase (AST), alanin...
Source: Medical Science Monitor - November 8, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Significant Diagnostic Value of Free-Serum PSA (FPSA)/Prostate-Specific Antigen Density (PSAD) and (F/T)/PSAD for Prostate Cancer of the Chinese Population in a Single Institution.
Authors: Nan LB, Yin XT, Gao JP Abstract BACKGROUND The aim of this study was to investigate the diagnostic value of (F/T)/PSAD for prostate cancer detection in the Chinese population. MATERIAL AND METHODS Data were collected retrospectively from patients with prostate cancer or benign prostatic hyperplasia from July 2009 to September 2014. SPSS 19.0 software was used for the receiver operating characteristic curve (ROC), and calculating sensitivity, specificity, and positive predictive values (PPV) and negative predictive values (NPV), respectively. Comparison of the area under ROC (AUC) was performed using the Me...
Source: Medical Science Monitor - November 8, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Lytic Bacteriophage Screening Strategies for Multidrug-Resistant Bloodstream Infections in a Burn Intensive Care Unit.
CONCLUSIONS The causative organisms of BSI and the presence of MDR in a hospital BICU were not typical, which supports the need for routine bacterial monitoring. Hospital sewage provides a potential source of bacteriophage for the treatment of MDR pathogenic bacteria. PMID: 31693655 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - November 8, 2019 Category: Research Tags: Med Sci Monit Source Type: research

lncRNA ZEB2-AS1 Aggravates Progression of Non-Small Cell Lung Carcinoma via Suppressing PTEN Level.
CONCLUSIONS lncRNA ZEB2-AS1 is upregulated in NSCLC, which elevates the viability and malignant degree of NSCLC cells by downregulating PTEN, thus aggravating the progression of NSCLC. PMID: 31695021 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - November 8, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Increased Levels of Glycated Hemoglobin A1c and Iron Deficiency Anemia: A Review.
Authors: Guo W, Zhou Q, Jia Y, Xu J Abstract Worldwide, the prevalence of diabetes remains high. Studies have shown that iron deficiency anemia (IDA) is associated with increased levels of glycated hemoglobin A1c (HbA1c), but the mechanism remains unclear. Hematological changes, iron metabolism, study methodology, and other factors could affect the results of diagnostic investigations, leading to false results. Red blood cell turnover in the bone marrow and the quality and heterogeneity of erythrocytes may influence the rate of hemoglobin glycation. By changing the structure of hemoglobin and inducing peroxidation,...
Source: Medical Science Monitor - November 8, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Biomechanical Comparison of Optimal Shapes for the Cervical Intervertebral Fusion Cage for C5-C6 Cervical Fusion Using the Anterior Cervical Plate and Cage (ACPC) Fixation System: A Finite Element Analysis.
CONCLUSIONS FE analysis identified the optimal cervical intervertebral cage design for ACPC fixation of C5-C6. This method may be useful for future developments in the design of spinal implants. PMID: 31697650 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - November 8, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Association Between Head and Neck Cancers and Polymorphisms 869T/C, 509C/T, and 915G/C of the Transforming Growth Factor- β1 Gene: A Meta-Analysis of Case-Control Studies.
CONCLUSIONS Data from this meta-analysis showed that the 869T/C and 915G/C polymorphisms of the TGF-ß1 gene might be associated with susceptibility to head and neck cancer. PMID: 31698408 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - November 8, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Skin Prick Testing to Identify Food Allergens in 8393 Children and Adolescents with Asthma in Chongqing, Southwest China.
CONCLUSIONS Identifying allergens is important for the diagnosis and management of allergic disorders, and for performing immunotherapy. PMID: 31676746 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - November 5, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Do Patients Diagnosed with Metastatic Pancreatic Cancer Benefit from Primary Tumor Surgery? A Propensity-Adjusted, Population-Based Surveillance, Epidemiology and End Results (SEER) Analysis.
Authors: Wang L, Yang L, Chen L, Chen Z Abstract BACKGROUND With the progress in surgical techniques and management of complications, pancreatic resection can be safely performed in experienced hospitals. Pancreatic resection enables surgeons to assess the effect of surgery for metastatic cases, even when there is limited information. In the present study we evaluated the role of primary tumor resection for metastatic pancreatic cancer (mPC) by using the Surveillance, Epidemiology and End Results (SEER) database. MATERIAL AND METHODS Metastatic pancreatic cancer patients treated at our hospital from 2004 to 2015 we...
Source: Medical Science Monitor - November 5, 2019 Category: Research Tags: Med Sci Monit Source Type: research

The Comparison of Parameters of Oxidative Stress in Native Rat Livers Between Different Immunosuppressive Regimens.
CONCLUSIONS Long-lasting immunosuppressive treatment does indeed affect redox status; however, the antioxidant defenses of the liver against the effects of excess hydrogen peroxide are efficient, so the superoxide dismutase/glutathione peroxidase (SOD/GPx) and superoxide dismutase/catalase (SOD/CAT) ratios were not significant. PMID: 31677379 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - November 5, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Establishment of the Prognosis Predicting Signature for Endometrial Cancer Patient.
CONCLUSIONS The OS and RFS predicting classifiers serve as independent prognosis-associated determiners for EC patients. PMID: 31678981 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - November 5, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Fecal Microbiota Taxonomic Shifts in Chinese Multiple Myeloma Patients Analyzed by Quantitative Polimerase Chain Reaction (QPCR) and 16S rRNA High-Throughput Sequencing.
CONCLUSIONS Our study highlights the imbalanced composition and diversity of the gastrointestinal microbiome in MM patients, which could be further used as a potential biomarker for MM risk screening, therapeutic strategies, and prognostic prediction. PMID: 31678982 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - November 5, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Vitamin D Deficiency/Insufficiency Is Associated with Risk of Osteoporotic Thoracolumbar Junction Vertebral Fractures.
CONCLUSIONS Vitamin D deficiency/insufficiency was associated with risk of osteoporotic thoracolumbar junction vertebral fractures in elderly patients. PMID: 31678984 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - November 5, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Protective Effects of MiR-129-5p on Acute Spinal Cord Injury Rats.
CONCLUSIONS Our findings suggested that overexpression of miR-129-5p improved neurological function by promoting functional recovery, reducing tissue loss and cell apoptosis in rats in an SCI model, possibly through downregulation of calpain1 and calpain2. PMID: 31680116 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - November 5, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Eupatilin Alleviates Lipopolysaccharide-Induced Acute Lung Injury by Inhibiting Inflammation and Oxidative Stress.
CONCLUSIONS Collectively, eupatilin alleviated LPS-induced ALI through inhibiting inflammation and oxidative stress in a concentration-dependent way, which was likely to be closely related with the activation of PPAR-alpha. PMID: 31680664 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - November 5, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Vitamin D Receptor Polymorphisms Associated with Susceptibility to Obesity: A Meta-Analysis.
This study aimed to assess whether the obesity susceptibility was associated with genetic variation in vitamin D receptor (VDR) gene by conducting a meta-analysis. MATERIAL AND METHODS PubMed, EMBASE and Cochrane Library databases were screened for all relevant articles published up to October 2018. The pooled odds ratios (OR) were calculated using STATA 13.0 software for 4 polymorphisms in the VDR gene (ApaI, BsmI, FokI and TaqI). RESULTS Seven case-control studies, including 1188 obese patients and 1657 healthy controls, were recruited. The pooled findings showed that there were no associations between obesity risk and t...
Source: Medical Science Monitor - November 5, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Systematic Pharmacological Methodology to Explore the Pharmacological Mechanism of Siwu Decoction for Osteoporosis.
Authors: Bao T, Yang K, Long Z, Zeng L, Li Y Abstract Osteoporosis is an important health problem worldwide. Siwu decoction (SWD) and its modification have a good clinical effect on osteoporosis. However, the molecular mechanism of SWD on osteoporosis has not been thoroughly explained. A systematic pharmacological methodology was utilized to predict the active compounds and potential targets of SWD, collect the genes of osteoporosis and the known targets of SWD, and analyze the osteoporosis and SWD's network. Five networks were constructed and analyzed: (1) Osteoporosis genes' protein-protein interaction (PPI) netw...
Source: Medical Science Monitor - November 2, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Baicalin Regulates Proliferation, Apoptosis, Migration, and Invasion in Mesothelioma.
CONCLUSIONS These results highlight the roles of baicalin in inhibiting cell growth, migration, and invasion of mesothelioma cells while increasing apoptosis and sensitizing cells to chemotherapeutic agents through the PI3K/AKT/mTOR signaling pathway, which indicates that baicalin could be a useful drug for mesothelioma therapy. PMID: 31670317 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - November 2, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Maresin-1 Inhibits Oxidative Stress and Inflammation and Promotes Apoptosis in a Mouse Model of Caerulein-Induced Acute Pancreatitis.
CONCLUSIONS In a mouse model of caerulein-induced AP, treatment with MaR1 reduced oxidative stress and inflammation and reduced apoptosis. PMID: 31671079 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - November 2, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Marital Status and Survival in Osteosarcoma Patients: An Analysis of the Surveillance, Epidemiology, and End Results (SEER) Database.
The objectives of this study were to determine the association between marital and survival rate of osteosarcoma patients based on the SEER database. MATERIAL AND METHODS We enrolled a total of 2725 osteosarcoma patients between 1973 and 2015, including 1184 married, 154 divorced/separated, 136 widowed, and 1251 never-married patients. Survival rate was determined based on the Kaplan-Meier method in different marital subgroups. Multivariate Cox regression analysis was performed to explore independent prognostic factors. RESULTS The 5-year overall survival (OS) and cancer-specific survival (CSS) rates of the married, separa...
Source: Medical Science Monitor - November 2, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Nuclear Factor kappa B (NF- κB) Targeted Self-Assembled Nanoparticles Loaded with Methotrexate for Treatment of Rheumatoid Arthritis.
CONCLUSIONS These findings highlight the potential of using this MTX-GC-SA nanoparticle formulation in suppressing inflammatory arthritis for effective treatment of RA. PMID: 31674342 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - November 2, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Risk Factors of Nosocomial Infection for Infants in Neonatal Intensive Care Units: A Systematic Review and Meta-Analysis.
Authors: Wang L, Du KN, Zhao YL, Yu YJ, Sun L, Jiang HB Abstract BACKGROUND The aim of this study was to identify the nosocomial infection (NI) risk factors in neonatal Intensive Care Units (NICU). MATERIAL AND METHODS Databases (PubMed, Embase, Cochrane, VANFUN, CNKI, and VTTMS) were searched using index words to find relevant studies published before November 2018. Meta-analyses of relative risk (RR) were performed for the identification of risk factors. RESULTS Data from 22 cohort studies (2270 infants with and 21 605 infants without NI) were included in the meta-analysis. Infant weight of
Source: Medical Science Monitor - November 2, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Higher Concentration of Hypertonic Saline Shows Better Recovery Effects on Rabbits with Uncontrolled Hemorrhagic Shock.
Authors: Xu L, Kang F, Hu W, Liu X Abstract BACKGROUND Our previous study found a novel fluid combination with better resuscitation effects under hypotensive condition at the early stage of uncontrolled hemorrhagic shock (UHS). However, the optimal recovery concentration of hypertonic saline in this fluid combination remains unknown. This experiment aimed to explore the optimal concentration. MATERIAL AND METHODS New Zealand white rabbits (n=40) were randomly divided into 5 groups, including a sham-operated group (SO), a shock non-treated group (SNT), a normal saline group (NS), and hypertonic saline groups (4.5% a...
Source: Medical Science Monitor - November 1, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Long Noncoding RNA TP73-AS1 Targets MicroRNA-329-3p to Regulate Expression of the SMAD2 Gene in Human Cervical Cancer Tissue and Cell Lines.
CONCLUSIONS LncRNA TP73-AS1 promoted proliferation of cervical cancer cell lines by targeting miR-329-3p to regulate the expression of the SMAD2 gene. A regulatory network was formed between lncRNA TP73-AS1, miR-329-3p, and SMAD2. PMID: 31663517 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - November 1, 2019 Category: Research Tags: Med Sci Monit Source Type: research

miR-34b Alleviates High Glucose-Induced Inflammation and Apoptosis in Human HK-2 Cells via IL-6R/JAK2/STAT3 Signaling Pathway.
CONCLUSIONS Our data suggest that overexpression of miR-34b improves inflammation and ameliorates apoptosis in HG-induced HK-2 cells via the IL-6R/JAK2/STAT3 pathway, indicating that miR-34b could be a promising therapeutic target in DN. PMID: 31665127 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - November 1, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Long Noncoding RNA Nuclear Enriched Abundant Transcript 1 (NEAT1) Regulates Proliferation, Apoptosis, and Inflammation of Chondrocytes via the miR-181a/Glycerol-3-Phosphate Dehydrogenase 1-Like (GPD1L) Axis.
CONCLUSIONS Our findings indicate that downregulation of NEAT1 aggravated progression of OA via modulating the miR-181a/GPD1L axis, providing a novel insight into the mechanism of OA pathogenesis. PMID: 31658244 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - October 30, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Upregulation of Long Noncoding RNA (lncRNA) X-Inactive Specific Transcript (XIST) is Associated with Cisplatin Resistance in Non-Small Cell Lung Cancer (NSCLC) by Downregulating MicroRNA-144-3p.
CONCLUSIONS Upregulation of lncRNA-XIST was associated with cisplatin resistance in NSCLC by downregulating miRNA-144-3p in H460/DDP and A549/DDP cells, a murine A549/DDP tumor xenograft, and human tumor tissues from patients with cisplatin-resistant NSCLC. PMID: 31659146 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - October 30, 2019 Category: Research Tags: Med Sci Monit Source Type: research

A Two Parameters for the Evaluation of Hypovolemia in Patients with Septic Shock: Inferior Vena Cava Collapsibility Index (IVCCI), Delta Cardiac Output.
Authors: Kaçar CK, Uzundere O, Yektaş A Abstract BACKGROUND The aim of this study was to determine the correlation between inferior vena cava collapsibility index and changes in cardiac output measured during passive leg raising test in patients with spontaneous breathing and septic shock. MATERIAL AND METHODS Fifty-six patients were included in the study. All of these 56 patients were diagnosed with septic shock and had spontaneous breathing under continuous positive airway pressure. Patients exclusions included: patients with cardiac pathology, not septic shock, pregnant, spontaneous breathing, increased ...
Source: Medical Science Monitor - October 30, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Relationship Between Diabetes Mellitus and Cirrhosis Risk in Chronic Hepatitis B Patients in Wuhan, China.
CONCLUSIONS DM was associated with cirrhosis risk in CHB patients in Wuhan, China. PMID: 31661471 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - October 30, 2019 Category: Research Tags: Med Sci Monit Source Type: research

A Pilot Study of Third-Generation Dual-Source Computed Tomography for the Assessment of Global Dynamic Changes in Left Ventricular Structure and Function in a Porcine Model of Acute Myocardial Infarction.
CONCLUSIONS Third-generation DSCT was validated as a tool for assessing dynamic changes in LV global function in a porcine model of AMI. PMID: 31649233 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - October 29, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Construction of a Competitive Endogenous RNA Network in Uterine Corpus Endometrial Carcinoma.
CONCLUSIONS Our study showed that the lncRNAs C2orf48 and LINC00261 might be key regulators of uterine corpus endometrial carcinoma and might serve as prognostic indicators. Our study contributes to the understanding of the molecular mechanisms of uterine corpus endometrial carcinoma, and it identifies lncRNAs that might serve as prognostic markers and therapeutic targets. PMID: 31650984 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - October 29, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Long Non-Coding RNA (LncRNA) CAIF is Downregulated in Osteoarthritis and Inhibits LPS-Induced Interleukin 6 (IL-6) Upregulation by Downregulation of MiR-1246.
CONCLUSIONS Therefore, CAIF may downregulate miR-1246 to improve OA. PMID: 31653823 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - October 29, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Xanthoxyletin Inhibits Proliferation of Human Oral Squamous Carcinoma Cells and Induces Apoptosis, Autophagy, and Cell Cycle Arrest by Modulation of the MEK/ERK Signaling Pathway.
CONCLUSIONS Xanthoxyletin inhibited the proliferation of human oral squamous carcinoma cells and induced apoptosis, autophagy, and cell cycle arrest by modulation of the MEK/ERK signaling pathway. PMID: 31654522 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - October 29, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Predicting Selection Preference of Robotic Pancreaticoduodenectomy (RPD) in a Chinese Single Center Population: Development and Assessment of a New Predictive Nomogram.
CONCLUSIONS This new nomogram could be conveniently used to predict the selection preference of robotic surgery for patients with pancreatic head cancer. PMID: 31654999 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - October 29, 2019 Category: Research Tags: Med Sci Monit Source Type: research

The Effects of Viewing Smart Devices on Static Balance, Oculomotor Function, and Dizziness in Healthy Adults.
This study aimed to investigate the effects of viewing smart devices, including SPs and HMDs, on postural balance and the development of dizziness in healthy individuals. MATERIAL AND METHODS Twenty-six healthy adults underwent static balance measurements at baseline, and after 5, 10, and 20 minutes of viewing the SP and HMD display. Measurements were taken using a force plate and Wii Balance Board (WBB) and included the parameters of postural sway velocity, path length, and postural sway area. A modified Simulator Sickness Questionnaire (SSQ) evaluated oculomotor function and dizziness twice for each device, after 5 and 2...
Source: Medical Science Monitor - October 29, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Causes and Factors Associated with Frequent Hospitalization in Chinese Patients with Systemic Lupus Erythematosus: An Ambispective Cohort Study.
CONCLUSIONS Nearly half of patients (46%) with SLE experience 1 or more hospitalizations, mainly due to SLE flare, infection, and pregnancy-related morbidity. Lupus patients with decreased albumin, decreased renal function, and high disease damage are more susceptible to have frequent hospitalization. PMID: 31655846 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - October 29, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Three-Dimensional Printed Titanium Scaffolds Enhance Osteogenic Differentiation and New Bone Formation by Cultured Adipose Tissue-Derived Stem Cells Through the IGF-1R/AKT/Mammalian Target of Rapamycin Complex 1 (mTORC1) Pathway.
CONCLUSIONS The 3D culture of ADSCs with 3DTi scaffolds enhanced osteogenic differentiation and new bone formation through the IGF-1R/AKT/mTORC1 pathway. This improved method of osteointegration may have clinical application in the preparation of bone grafts before implantation for improved repair of mandibular bone defects. PMID: 31655847 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - October 29, 2019 Category: Research Tags: Med Sci Monit Source Type: research