Dietary Melatonin Therapy Alleviates the Lamina Cribrosa Damages in Patients with Mild Cognitive Impairments: A Double-Blinded, Randomized Controlled Study.
This study aimed to investigate the melatonin induced effects on the lamina cribrosa thickness (LCT) of patients with MCI. MATERIAL AND METHODS The LCT data of patients with MCI were compared to LCT data of healthy controls. Subsequently, all MCI patients were randomly assigned into an experimental group (with melatonin treatment) or a placebo group (without any melatonin treatment). RESULTS The LCT of MCI patients decreased significantly compared with healthy controls. The univariate analysis showed that the lower the Mini Mental State Examination (MMSE) score (P=0.038; 95% CI: 0.876, -0.209), the smaller hippocampus volu...
Source: Medical Science Monitor - May 8, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Dietary Calcium Intake and HPV Infection Status Among American Women: A Secondary Analysis from National Health and Nutrition Examination Survey (NHANES) Data Set of 2003  - 2016.
CONCLUSIONS At the range of 3.32-9.78 of log2 calcium intake, DCa intake was negatively correlated with HPV infection. After this interval, DCa intake was not associated with the risk of HPV infection. PMID: 32378682 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - May 8, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Epidemiological Analysis of the First 1389 Cases of COVID-19 in Poland: A Preliminary Report.
CONCLUSIONS The proportion of women and men with confirmed COVID-19 infection was similar to the sex ratio in the general population. Infections were relatively less common in those aged under 20 years. The largest numbers of confirmed cases were detected in 3 of the 4 largest cities, each of which has an international airport. PMID: 32379726 [PubMed - as supplied by publisher] (Source: Medical Science Monitor)
Source: Medical Science Monitor - May 8, 2020 Category: Research Tags: Med Sci Monit Source Type: research

An Evidence Based Perspective on mRNA-SARS-CoV-2 Vaccine Development.
Authors: Wang F, Kream RM, Stefano GB Abstract The first outbreak of coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) occurred in Wuhan, Hubei Province, China, in late 2019. The subsequent COVID-19 pandemic rapidly affected the health and economy of the world. The global approach to the pandemic was to isolate populations to reduce the spread of this deadly virus while vaccines began to be developed. In March 2020, the first phase I clinical trial of a novel lipid nanoparticle (LNP)-encapsulated mRNA-based vaccine, mRNA-1273, which encodes the spike prot...
Source: Medical Science Monitor - May 7, 2020 Category: Research Tags: Med Sci Monit Source Type: research

COVID-19 Dynamic Computed Tomography (CT) Performance and Observation of Some Laboratory Indicators.
CONCLUSIONS The dynamic changes of CT images of lungs of COVID-19 patients, combined with the clinical manifestations and laboratory indicators of patients, can help guide clinical diagnosis and treatment. PMID: 32367888 [PubMed - indexed for MEDLINE] (Source: Medical Science Monitor)
Source: Medical Science Monitor - May 7, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Exosomes Derived from Bone Marrow Stromal Cells (BMSCs) Enhance Tendon-Bone Healing by Regulating Macrophage Polarization.
CONCLUSIONS Our study provides evidence that the local administration of BMSC-Exos promotes the formation of fibrocartilage by increasing M2 macrophage polarization in tendon-to-bone healing, leading to improved biomechanical properties. These findings provide a basis for the potential clinical use of BMSC-Exos in tendon-bone repair. PMID: 32369458 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - May 7, 2020 Category: Research Tags: Med Sci Monit Source Type: research

A Comparative Study of Conservation, Endovascular Embolization Therapy, and Surgery for Blunt Renal Trauma.
CONCLUSIONS The success rate of angioembolization was high and protected renal function to the greatest extent, and there were no differences in renal function at long-term follow-up. However, it is difficult to manage renal vessel laceration or avulsion by embolization alone, and various endovascular therapies are required to protect the function of residual kidneys. PMID: 32372763 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - May 7, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Inhibition Effect of Dictyophora Polysaccharides on Human Hepatocellular Carcinoma Cell Line HCC-LM3.
CONCLUSIONS To the best of our knowledge, this is the first published study on the mechanism of Dictyophora polysaccharide inhibition of HCC-LM3 cell proliferation. PMID: 32374722 [PubMed - as supplied by publisher] (Source: Medical Science Monitor)
Source: Medical Science Monitor - May 7, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Oridonin Alleviates IRI-Induced Kidney Injury by Inhibiting Inflammatory Response of Macrophages via AKT-Related Pathways.
CONCLUSIONS Oridonin ameliorates AKI kidney injuries by suppressing AKT-mediated inflammatory response of macrophages. PMID: 32362652 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - May 6, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Effect of a Specific Questionnaire Sheet on Subclassification of Osteonecrosis of the Femoral Head.
CONCLUSIONS The use of a specific questionnaire sheet can change the distribution of ONFH subclassifications compared with use of a conventional medical history interview. Use of a specific questionnaire sheet can allow for more detailed self-reporting regarding potential causative factors for nontraumatic ONFH, especially habitual alcohol intake. PMID: 32364184 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - May 6, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Effective Chemotherapy of Lung Cancer Using Bovine Serum Albumin-Coated Hydroxyapatite Nanoparticles.
CONCLUSIONS Our hybrid DDS shows potential to be applied in more advanced application of cancer therapy. PMID: 32365057 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - May 6, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Changes in Foot Skin Microbiome of Patients with Diabetes Mellitus Using High-Throughput 16S rRNA Gene Sequencing: A Case Control Study from a Single Center.
This study aimed to use high-throughput 16S rRNA gene sequencing to investigate the changes in foot skin microbiome of patients with diabetes mellitus from a single center in China. MATERIAL AND METHODS Fifty-two participants were divided into 4 study groups: healthy controls (n=13); patients with short-term diabetes (10 years; n=13). Swabs were analyzed from the intact skin of the foot arch using high-throughput 16S ribosomal RNA sequencing. RESULTS Microbiome phylogenic diversity varied significantly between the study groups (whole tree, P
Source: Medical Science Monitor - May 4, 2020 Category: Research Tags: Med Sci Monit Source Type: research

The Main Bottleneck for Non-Metastatic Pancreatic Adenocarcinoma in Past Decades: A Population-Based Analysis.
CONCLUSIONS The development of chemotherapy and radiotherapy has been slow, especially for unresectable PDAC. Although advances in surgery contributed significantly to improved survival for resectable PDAC, lack of early diagnostic tools, which lead to low resection rates, remain a barrier for all PDAC patients. PMID: 32358953 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - May 4, 2020 Category: Research Tags: Med Sci Monit Source Type: research

The AGT Haplotype of the ESR2 Gene Containing the Polymorphisms rs2077647A, rs4986938G, and rs1256049T Increases the Susceptibility of Unexplained Recurrent Spontaneous Abortion in Women in the Chinese Hui Population.
CONCLUSIONS The AGT haplotype of the ESR2 gene containing the polymorphism rs2077647A, rs4986938G, and rs1256049T (ESR2 hapAGT) was a protective factor for URSA in women in the Chinese Hui population when compared with the Chinese Han population. PMID: 32359133 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - May 4, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Inhibition of MiR-10b Restrains the Migration and Epithelial-Mesenchymal Transition of Lung Cells by Targeting LATS2 via TAZ Pathway.
CONCLUSIONS MiR-10b was upregulated in lung cancer. Inhibition of miR-10b could restrain the development of lung cancer by increasing LATS2 expression via TAZ. PMID: 32361707 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - May 4, 2020 Category: Research Tags: Med Sci Monit Source Type: research

The Effects of microRNA-515-5p on the Toll-Like Receptor 4 (TLR4)/JNK Signaling Pathway and WNT1-Inducible-Signaling Pathway Protein 1 (WISP-1) Expression in Rheumatoid Arthritis Fibroblast-Like Synovial (RAFLS) Cells Following Treatment with Receptor Activator of Nuclear Factor-kappa-B Ligand (RANKL).
CONCLUSIONS In RAFLS cells, miR-515-5p inhibited the expression of the WISP1 gene, and treatment with RANKL inhibited the TLR4/JNK signaling pathway. PMID: 32361708 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - May 4, 2020 Category: Research Tags: Med Sci Monit Source Type: research

RUNX3 Polymorphisms Affect the Risk of Ankylosing Spondylitis.
CONCLUSIONS RUNX3 rs760805 polymorphism can contribute to AS incidence in Chinese Han people. The interaction of the 2 polymorphisms may be a risk factor for AS. PMID: 32355155 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - May 3, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Application of Insertable Cardiac Monitor in Establishing a Dog Model of Atrial Fibrillation by High-Frequency Right Atrial Pacing.
CONCLUSIONS The application of insertable cardiac monitor Reveal LINQ improves the efficiency of monitoring the AF load, with high sensitivity, convenience, and accuracy. PMID: 32356526 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - May 3, 2020 Category: Research Tags: Med Sci Monit Source Type: research

The Effect of Long Non-Coding RNA (lncRNA) HCP5 on Regulating Epithelial-Mesenchymal Transition (EMT)-Related Markers in Gastric Carcinoma Is Partially Reversed by miR-27b-3p.
CONCLUSIONS The effect of silencing HCP5 on repressing GC cells viability and metastasis by regulating EMT-associated markers can be partially reversed by miR-27b-3p inhibitor. PMID: 32357145 [PubMed - as supplied by publisher] (Source: Medical Science Monitor)
Source: Medical Science Monitor - May 3, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Research Progress of N6-Methyladenosine in the Cardiovascular System.
Authors: Zheng N, Su J, Hu H, Wang J, Chen X Abstract According to the World Health Organization cardiovascular disease risk charts, the mortality rate of cardiovascular diseases in people is still high. The medical expenses caused by cardiovascular diseases are increasing daily, and the medical burden is becoming heavier; as such, it is imperative to prevent and cure cardiovascular diseases. A large number of scholars are analyzing the pathogenesis of cardiovascular diseases from various perspectives. Recent findings suggest that N6-methyladenosine (m6A) plays a multifaceted role in the cardiovascular system. m6A ...
Source: Medical Science Monitor - May 1, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Carbon Monoxide Inhibits the Expression of Proteins Associated with Intestinal Mucosal Pyroptosis in a Rat Model of Sepsis Induced by Cecal Ligation and Puncture.
CONCLUSIONS In a rat model of sepsis induced by CLP, CO had a protective role by inhibiting intestinal mucosal pyroptosis. PMID: 32351244 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - May 1, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Comparison of Efficacies of Commonly Used Hypertension Treatment Modalities: A Retrospective Study of 1900 Participants in a Hypertension Clinic.
Authors: Zhao X, Dahal A, Yang Q, Yang Y, Ding Z, Wang J, Swai JD, Jiang W, Li X Abstract BACKGROUND Although various antihypertensive medications are available, some hypertensive patients have uncontrolled blood pressures, especially in the clinic. The aim of the present study was to compare the efficacies of various antihypertensive therapies in our hypertension (HTN) clinic (monotherapy vs. combination therapy, fixed-dose combination (FDC) versus free equivalent combination (FEC), and diuretics versus non-diuretics. MATERIAL AND METHODS In this retrospective study, patients at the HTN clinic of the Third Xiangya...
Source: Medical Science Monitor - May 1, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Apoptosis Activation in Thyroid Cancer Cells by Jatrorrhizine-Platinum(II) Complex via Downregulation of PI3K/AKT/Mammalian Target of Rapamycin (mTOR) Pathway.
CONCLUSIONS The JR-P(II) induced cytotoxicity in thyroid cancer cells by inhibiting the mechanism responsible for repair of double-stranded DNA. The in vivo data also revealed that JR-P(II) effectively inhibits thyroid tumor growth by inducing DNA damage. Thus, our results suggest that further evaluation of JR-P(II) as a therapeutic candidate for thyroid cancer is warranted. PMID: 32341329 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - April 30, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Icariin Promotes Fracture Healing in Ovariectomized Rats.
CONCLUSIONS These results revealed that icariin could promote fracture healing in ovariectomized rats via OPG/RANKL signaling, and that serum E₂ and uterine index were not affected by icariin treatment. PMID: 32342947 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - April 30, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Silencing Signal Transducer and Activator of Transcription 3 (STAT3) and Use of Anti-Programmed Cell Death-Ligand 1 (PD-L1) Antibody Induces Immune Response and Anti-Tumor Activity.
CONCLUSIONS Silencing STAT3 and PD-L1 antibody injection in combination increased apoptosis in tumor cells and thus offers better anti-cancer activity. PMID: 32343679 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - April 30, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Clinical Outcomes of Intraoperative Contrast-Enhanced Ultrasound Compared with Intraoperative Neurophysiological Monitoring During Circumferential Decompression for Myelopathy Associated with Thoracic-Ossification of the Posterior Longitudinal Ligament.
This study is the first to describe the use of contrast-enhanced ultrasound (CEUS) to evaluate the spinal cord blood flow (SCBF) during thoracic spine surgery in humans. The objective of this study was to compare clinical outcomes between intraoperative CEUS and IONM during CD. MATERIAL AND METHODS Sixty-eight T-OPLL patients who received CD from 2007 to 2014 were reviewed. All patients underwent IONM. CEUS was used on the following 2 occasions on 18 patients to evaluate SCBF: the first measurement was performed after laminectomy and the second after ventral decompression. Outcomes were evaluated by the Hirabayashi recover...
Source: Medical Science Monitor - April 30, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Evaluation of Long-Term Quality of Life Using the Foot and Ankle Outcome Score (FAOS) Questionnaire in Patients Treated by Minimally Invasive Reduction and Percutaneous Stabilization of Intra-Articular Calcaneal Fractures.
CONCLUSIONS According to set criteria regarding the FAOS scale, mainly good and very good results were observed in patients treated surgically for intra-articular calcaneus fractures using MIRPS. Westhues' method scored a significantly higher foot rating than W-R (Westhues'-Rąpała method). Patients with TTF (tongue-type fracture) scored higher in the FAOS than patients treated with JDTF (joint depression-type fracture). In other cases, no significant differences were observed. PMID: 32347218 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - April 30, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Prognostic Value of Lymph Node Ratio in Breast Cancer Patients with Adequate Pathologic Evidence After Neoadjuvant Chemotherapy.
This study was designed to investigate the prognostic role of LNR in breast cancer compared with traditional ypN stage. MATERIAL AND METHODS A total of 306 breast cancer patients diagnosed with positive axillary lymph nodes from January 2007 to December 2014 were eligible for this retrospective analysis. All enrolled patients were treated with a median of 4 cycles of NAC followed by mastectomy and level I, II, and III axillary lymph node dissection (ALND). RESULTS The median duration of follow-up was 78 months (range, 7-147 months). Univariate analysis indicated that both the LNR category (P
Source: Medical Science Monitor - April 30, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Endomorphin-2 Analog Inhibits the Growth of DLD-1 and RKO Human Colon Cancer Cells by Inducing Cell Apoptosis.
CONCLUSIONS Endomorphin-2 analog inhibited colon cancer cell proliferation, activated apoptosis, and down-regulated Akt phosphorylation of human DLD-1 and RKO colon cancer cells in vitro in a dose-dependent manner. PMID: 32336747 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - April 29, 2020 Category: Research Tags: Med Sci Monit Source Type: research

The Antithrombotic Effects of Low Molecular Weight Fragment from Enzymatically Modified of Laminaria Japonica Polysaccharide.
CONCLUSIONS LMWEP, an enzymatically modified fragment with a molecular weight of 25.8 kDa, is a potential antithrombotic candidate for treatment of thrombosis related diseases. PMID: 32338252 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - April 29, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Comparative Study of the Effectiveness and Safety of Transurethral Bipolar Plasmakinetic Enucleation of the Prostate and Transurethral Bipolar Plasmakinetic Resection of the Prostate for Massive Benign Prostate Hyperplasia ( > 80 ml).
Comparative Study of the Effectiveness and Safety of Transurethral Bipolar Plasmakinetic Enucleation of the Prostate and Transurethral Bipolar Plasmakinetic Resection of the Prostate for Massive Benign Prostate Hyperplasia (>80 ml). Med Sci Monit. 2020 Apr 27;26:e921272 Authors: Jiang Y, Bai X, Zhang X, Wang M, Tian J, Mu L, Zhang N, Li M, Du Y Abstract BACKGROUND The aim of this study was to compare the clinical safety and effectiveness of transurethral bipolar plasmakinetic enucleation of the prostate (PKEP) vs. transurethral bipolar plasmakinetic resection of the prostate (PKRP) in the treatment ...
Source: Medical Science Monitor - April 29, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Sevoflurane Postconditioning Reduces Hypoxia-Reoxygenation Injury in H9C2 Embryonic Rat Cardiomyocytes and Targets the STRADA Gene by Upregulating microRNA-107.
CONCLUSIONS SpostC reduced H/R injury in H9C2 embryonic rat cardiomyocytes by targeting the STRADA gene and by upregulating the expression of microRNA-107. PMID: 32332694 [PubMed - as supplied by publisher] (Source: Medical Science Monitor)
Source: Medical Science Monitor - April 27, 2020 Category: Research Tags: Med Sci Monit Source Type: research

A Mouse Model of 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine (MPTP)-Induced Parkinson Disease Shows that 2-Aminoquinoline Targets JNK Phosphorylation.
This study aimed to investigate the effects of 2-aminoquinoline on motor deficits in a mouse model of MPTP-induced PD and cultured mouse astrocytes treated with MPP+, to determine the effects on astrocyte proliferation and apoptosis. MATERIAL AND METHODS Motor deficits in the mouse model of MPTP-induced PD were investigated using the climbing time, suspension time, and swim time tests. Cultured mouse astrocytes were treated with MPP+, and mice with MPTP-induced PD were treated with increasing doses of 2-aminoquinoline. The MTT assay was used to measure astrocyte viability. Astrocyte apoptosis was assessed by confocal fluor...
Source: Medical Science Monitor - April 27, 2020 Category: Research Tags: Med Sci Monit Source Type: research

NAF1 rs4691896 Is Significantly Associated with Coal Workers' Pneumoconiosis in a Chinese Han Population: A Case-Control Study.
CONCLUSIONS Our study for the first time demonstrates an association between a telomere-related gene (NAF1) and CWP in a Chinese Han population, and provides valuable insight to further understand the possible pathogenetic mechanism of fibrosis in CWP. PMID: 32333749 [PubMed - as supplied by publisher] (Source: Medical Science Monitor)
Source: Medical Science Monitor - April 27, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Comparison of Perioperative and Oncological Outcomes of Hybrid and Totally Laparoscopic Pancreatoduodenectomy.
This study aimed to prove whether the hybrid procedure is a safe procedure during a surgeon's learning curve of LPD. MATERIAL AND METHODS There were 48 hybrid LPD patients and 62 TLPD patients selected from January 2016 to December 2018; their demographics, surgical outcomes, and oncological data were retrospectively collected. Patient follow-up for the study continued until February 2020. RESULTS Patient demographics and baseline parameters were well balanced between the 2 groups. Intraoperative conditions, overall operation time was shorter for TLPD compared to hybrid LPD (407.79 minutes versus 453.29 minutes, respective...
Source: Medical Science Monitor - April 27, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Comparison of Prevalence and Associated Factors of Anxiety and Depression Among People Affected by versus People Unaffected by Quarantine During the COVID-19 Epidemic in Southwestern China.
CONCLUSIONS The prevalence of anxiety and depression of the affected group are higher than in the unaffected group during the COVID-19 outbreak in southwestern China in early Feb. 2020. The government should focus more on providing economic and medical support to improve the general population's mental state. PMID: 32335579 [PubMed - as supplied by publisher] (Source: Medical Science Monitor)
Source: Medical Science Monitor - April 27, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Myricetin Prevents Cataract Formation by Inhibiting the Apoptotic Cell Death Mediated Cataractogenesis.
Authors: Yang Y, Xu X, Liu Q, Huang H, Huang X, Lv H Abstract BACKGROUND The current research work aimed to explore the protective role of myricetin against cataractogenesis in humans, in terms of its anti-apoptotic potential. MATERIAL AND METHODS Human eye lens epithelial cells were exposed to oxidative stress by treating with hydrogen peroxide (H₂O₂). The levels of superoxide dismutase (SOD), catalase (CAT), and glutathione (GSH) were determined using standard detection kits. DAPI (4',6-diamidino-2-phenylindole), AO/EB (acridine orange/ethidium bromide) and Annexin V/propidium iodide (PI) staining assays were...
Source: Medical Science Monitor - April 27, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Comparative Effectiveness of Tadalafil versus Tamsulosin in Treating Lower Urinary Tract Symptoms Suggestive of Benign Prostate Hyperplasia: A Meta-Analysis of Randomized Controlled Trials.
CONCLUSIONS Tadalafil and tamsulosin have similar effects in managing LUTS secondary to BPH. Tadalafil is superior to tamsulosin in treating LUTS suggestive of BPH when associated with erectile dysfunction (ED). PMID: 32327621 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - April 26, 2020 Category: Research Tags: Med Sci Monit Source Type: research

MicroRNA-328-3p Protects Vascular Endothelial Cells Against Oxidized Low-Density Lipoprotein Induced Injury via Targeting Forkhead Box Protein O4 (FOXO4) in Atherosclerosis.
CONCLUSIONS MiR-328-3p protected vascular endothelial cells against ox-LDL induced injury via targeting FOXO4, suggesting a novel insight for atherosclerosis treatment. PMID: 32329448 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - April 26, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Protocadherin 8 (PCDH8) Inhibits Proliferation, Migration, Invasion, and Angiogenesis in Esophageal Squamous Cell Carcinoma.
CONCLUSIONS PCDH8 exerts a tumor-suppressive effect against ESCC cells. However, further studies are required to elucidate the exact molecular mechanism underlying the antitumor activity of PCDH8 in ESCC. PMID: 32330123 [PubMed - as supplied by publisher] (Source: Medical Science Monitor)
Source: Medical Science Monitor - April 26, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Long Non-Coding RNA (lncRNA) CRNDE Regulated Lipopolysaccharides (LPS)-Induced MRC-5 Inflammation Injury Through Targeting MiR-141.
CONCLUSIONS In this study, we found that downregulation of CRNDE and upregulation of miR-141 inhibited cell apoptosis and inflammation response and promoted cell viability in LPS-induced MRC-5 cells. Low CRNDE expression increased cell growth and suppressed inflammation response, which was impaired by inhibition of miR-141. These results suggested that a novel therapeutic target was found in pneumonia treatment. PMID: 32317619 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - April 24, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Progress in Research on Sperm DNA Fragmentation.
Authors: Qiu Y, Yang H, Li C, Xu C Abstract With the increasing incidence of male infertility, routine detection of semen is insufficient to accurately assess male fertility. Infertile men, who have lower odds of conceiving naturally, exhibit high levels of sperm DNA fragmentation (SDF). The mechanisms driving SDF include abnormal spermatogenesis, oxidative stress damage, and abnormal sperm apoptosis. As these factors can induce SDF and subsequent radical changes leading to male infertility, detection of the extent of SDF has become an efficient routine method for semen analysis. Although it is still debated, SDF d...
Source: Medical Science Monitor - April 24, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Prohibitin 2/PHB2 in Parkin-Mediated Mitophagy: A Potential Therapeutic Target for Non-Small Cell Lung Carcinoma.
CONCLUSIONS Our results suggest that downregulation of PHB2 reduced parkin-mediated mitophagy, which suppressed proliferation and migration of A549 and H1299 cells. PMID: 32320388 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - April 24, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Baicalin Inhibits Cell Proliferation and Inflammatory Cytokines Induced by Tumor Necrosis Factor α (TNF-α) in Human Immortalized Keratinocytes (HaCaT) Human Keratinocytes by Inhibiting the STAT3/Nuclear Factor kappa B (NF-κB) Signaling Pathway.
CONCLUSIONS Baicalin inhibited the proliferation and expression of inflammatory cytokines in HaCaT immortalized human keratinocytes in vitro through the inhibition of the STAT3/NF-kappaB signaling pathway. PMID: 32321906 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - April 24, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Asperosaponin VI Injection Enhances Orthodontic Tooth Movement in Rats.
CONCLUSIONS Injection of ASA VI may accelerate tooth movement via increasing the activity of osteoclasts, stimulating bone resorption at the compression side. Furthermore, ASA VI has a positive effect on bone formation at the tension side. PMID: 32323648 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - April 24, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Effect of Sleeve Gastrectomy on Bone Metabolism and Serum 5-Hydroxytryptamine in Obese Rats.
CONCLUSIONS BMD was decrease and bone metabolism demonstrated a trend of bone destruction after SG. SG can affect the level of 5-HT in serum or bone tissue and the 5-HT may be involved in the process through which SG affects bone metabolism. PMID: 32324718 [PubMed - as supplied by publisher] (Source: Medical Science Monitor)
Source: Medical Science Monitor - April 24, 2020 Category: Research Tags: Med Sci Monit Source Type: research

The Effects of Interleukin-33 (IL-33) on Osteosarcoma Cell Viability, Apoptosis, and Epithelial-Mesenchymal Transition are Mediated Through the PI3K/AKT Pathway.
CONCLUSIONS IL-33 was highly expressed in human osteosarcoma cells. Down-regulation of IL-33 reduced cell viability and EMT of osteosarcoma cells, and induced cell apoptosis through activation of the PI3K/AKT signaling pathway. PMID: 32312946 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - April 23, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Insulin-Like Growth Factor 1 (IGF1) Pathway Member Polymorphisms Are Associated with Risk and Prognosis of Chondrosarcoma.
CONCLUSIONS We hypothesized that IGF1 member polymorphisms are associated with chondrosarcoma. We found that genetic polymorphisms in IGF1 pathway members are associated with elevated risk and poor prognosis of conventional CHS patients in Chinese populations. IGF1R rs2016347 polymorphisms were associated with the risk of lung metastasis of CHS. The IGF1 pathway members do not appear to be involved in the tumorigenesis of CHS. PMID: 32314747 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - April 23, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Patterns of Alcohol Consumption and Drinking Motives Among Korean Medical Students.
CONCLUSIONS Heavy drinking and binge drinking are common among both male and female medical students in Korea and this behavior is associated with smoking and enhancement drinking motives. Medical schools should consider implementing effective interventions to prevent and reduce problem drinking among medical students. PMID: 32315293 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - April 23, 2020 Category: Research Tags: Med Sci Monit Source Type: research

The Effects of a Toothpaste Containing the Active Ingredients of Galla chinensis and Sodium Fluoride on Dentin Hypersensitivity and Sealing of Dentinal Tubules: An In Vitro Study and an Eight-Week Clinical Study in 98 Patients.
CONCLUSIONS Toothpaste that contained the active ingredients of Galla chinensis and sodium fluoride reduced the symptoms of dentin hypersensitivity by sealing the dentinal tubules. PMID: 32307404 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - April 21, 2020 Category: Research Tags: Med Sci Monit Source Type: research