Maternal Serum and Fetal Cord Blood C-Reactive Protein Levels but not Procalcitonin Levels Are Increased in Idiopathic Intrauterine Growth Restriction.
CONCLUSIONS Maternal serum and fetal cord CRP levels were higher in the IUGR group; however, there was no difference in procalcitonin, which is another inflammatory indicator, between the groups. PMID: 31469126 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - September 1, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Conditional Survival in Patients with Advanced Renal Cell Carcinoma Treated with Nivolumab.
CONCLUSIONS Survival benefit for patients with advanced RCC from nivolumab (plus ipilimumab) compared with sunitinib was more evident from conditional survival (CS) analysis of first-line treatment. PMID: 31469816 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - September 1, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Diabetic Nephropathy versus Diabetic Retinopathy in a Chinese Population: A Retrospective Study.
The objective of this study was to test the hypothesis that diabetic nephropathy patients with and without diabetic retinopathy have different clinical and laboratory profiles. MATERIAL AND METHODS Medical records of type 2 diabetes mellitus patients with confirmed diabetic nephropathy were reviewed and analyzed with appropriate statistical modalities. Presence of arteriolar sclerosis of the carotid artery, abdominal aorta, upper extremities, and first-order aortic branches was regarded as a peripheral vascular disease. RESULTS Out of 217 type 2 diabetes mellitus patients with confirmed diabetic nephropathy, retinopathy wa...
Source: Medical Science Monitor - August 30, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Circular RNA CircMTO1 Inhibits Proliferation of Glioblastoma Cells via miR-92/WWOX Signaling Pathway.
CONCLUSIONS Our results demonstrate that circMTO1 inhibits the proliferation of glioblastoma cells via the miR-92/WWOX signaling pathway. PMID: 31456594 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 30, 2019 Category: Research Tags: Med Sci Monit Source Type: research

High-Mobility Group Box 1 (HMGB1) Induces Migration of Endothelial Progenitor Cell via Receptor for Advanced Glycation End-Products (RAGE)-Dependent PI3K/Akt/eNOS Signaling Pathway.
CONCLUSIONS These data demonstrate that HMGB1 activates RAGE and induces PI3K/Akt/eNOS signaling transduction pathway activation to promote EPC migration. Therefore, the HMGB1-RAGE axis plays an important role in the EPC migration process and may become a potential target in wound healing. PMID: 31461437 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 30, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Platelet/Lymphocyte, Lymphocyte/Monocyte, and Neutrophil/Lymphocyte Ratios as Biomarkers in Patients with Rheumatoid Arthritis and Rheumatoid Arthritis-Associated Interstitial Lung Disease.
The objective of this study was to assess the diagnostic value of platelet/lymphocyte ratio (PLR), lymphocyte/monocyte ratio (LMR), and neutrophil/lymphocyte ratio (NLR) as biomarkers in patients with rheumatoid arthritis (RA) and rheumatoid arthritis-associated interstitial lung disease (RA-ILD). MATERIAL AND METHODS Demographic and laboratory data were acquired for 198 RA and 103 RA-ILD patients and 290 healthy controls. The subjects were categorized into female and male groups and further subcategorized based on age into
Source: Medical Science Monitor - August 30, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Whole Mitochondrial DNA Sequencing Analysis in 47 Han Populations in Southwest China.
CONCLUSIONS Whole mtDNA sequencing distinguished between individuals from 47 Chongqing Han populations in southwest China and has potential applications that include high-quality forensic identification. PMID: 31464266 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 30, 2019 Category: Research Tags: Med Sci Monit Source Type: research

EXT1, Regulated by MiR-665, Promotes Cell Apoptosis via ERK1/2 Signaling Pathway in Acute Lymphoblastic Leukemia.
CONCLUSIONS In conclusion, this study is the first to confirm the association between low EXT1 levels and several clinical features of ALL. Low bone marrow EXT1 levels independently predict poor prognoses in adult ALL patients. Thus, our study suggests that EXT1- or miR-665-targeted strategies can confer the therapeutic effect of promoting apoptosis by deactivating the ERK1/2 pathway. PMID: 31465316 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 30, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Expression of KIF18A Is Associated with Increased Tumor Stage and Cell Proliferation in Prostate Cancer.
CONCLUSIONS High KIF18A expression in prostate cancer patients predicts a poor prognosis. KIF18A knockdown inhibits prostate cell proliferation and metastasis. Therefore, this study confirms the usefulness of KIF18A as an oncological prognostic indicator and a potential therapeutic target for prostate cancer. PMID: 31451680 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 29, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Long Non-Coding RNA (lncRNA) X-Inactive Specific Transcript (XIST) Plays a Critical Role in Predicting Clinical Prognosis and Progression of Colorectal Cancer.
Authors: Zhang XT, Pan SX, Wang AH, Kong QY, Jiang KT, Yu ZB Abstract BACKGROUND Long non-coding RNAs (lncRNAs) participate in all cancer biology processes of cells. Although functions and associated mechanisms of lncRNAs have been proven in colorectal cancer (CRC), the roles of lncRNA X-inactive specific transcript (XIST) have not been clearly investigated in CRC. MATERIAL AND METHODS Expression of XIST was detected by quantitative real-time PCR (qRT-PCR) assay in CRC cell lines and 196 clinical samples. Correlations between XIST expression and CRC clinicopathological features were analyzed. Log-rank test and Kapl...
Source: Medical Science Monitor - August 29, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Intra-Articular Viscosupplementation for Patients with Hip Osteoarthritis: A Meta-Analysis and Systematic Review.
CONCLUSIONS IA VS does not reduce pain or improve function significantly better than placebo in a short-term follow-up. The benefits and safety of VS should be further assessed by sufficiently-sized, methodologically sound studies with validated assessment of more clinically relevant end-points. PMID: 31454342 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 29, 2019 Category: Research Tags: Med Sci Monit Source Type: research

The Roles of Circular RNAs in Osteosarcoma.
Authors: Zhang Y, Li J, Wang Y, Jing J, Li J Abstract Osteosarcoma is a malignant tumor that occurs most commonly in the metaphysis of the long bones in the limbs in children and adolescents. Even with surgery and neoadjuvant chemotherapy, the therapeutic effect has reached a peak with 60-70% survival rates. Therefore, new biological targets or molecular mechanisms that enhance the efficacy of osteosarcoma treatments are needed. Circular RNAs (circRNAs) are useful biomarkers that have recently been recognized clinically and in medical research and have been of interest due to the use of next-generation sequencing a...
Source: Medical Science Monitor - August 27, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Age-Related Macular Degeneration and Associated Risk Factors in the Population-Based Study of Health in Pomerania (SHIP-Trend).
Authors: Lüdtke L, Jürgens C, Ittermann T, Völzke H, Tost F Abstract BACKGROUND Age-related macular degeneration (AMD) is the leading cause of visual impairment in developed countries, especially in the older population. The Study of Health in Pomerania (SHIP) is a population-based study designed to investigate risk factors and clinical disorders in the general population. In the present study, we analysed the AMD prevalence and risk factors in the north-eastern German population. MATERIAL AND METHODS From 2008 to 2012, we collected data among participants ages 29-79 years. The study population consi...
Source: Medical Science Monitor - August 27, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Single-Operator Wire-Guided Cannulation Technique for Endoscopic Retrograde Cholangiopancreatography.
CONCLUSIONS Compared with regular ERCP, SOCT achieved the same effects without the help of an experienced assistant, which could make the procedure useful in primary hospitals. PMID: 31446437 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 27, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Awareness of the Benefits and Risks Related to Using Fluoridated Toothpaste Among Doctors: A Population-Based Study.
This study aimed to assess the awareness of dentists and non-dental doctors regarding the benefits and risks of using fluoridated toothpaste. MATERIAL AND METHODS A self-administered questionnaire was used to collect information in this study. Multistage cluster sampling method was used to enroll doctors in 5 districts or counties in Chongqing, China. A total of 403 doctors (160 dentists and 243 non-dental doctors) completed the questionnaire. RESULTS The awareness of the anti-caries efficacy and the usage of fluoridated toothpaste in dentists was significantly higher than those of non-dental doctors (P
Source: Medical Science Monitor - August 27, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Association of Platelet Membrane Fatty Acid Composition with Markers of Oxidative Stress in Healthy Men.
CONCLUSIONS MDA and the formation of platelet-monocyte aggregates stimulate the incorporation of monounsaturated fatty acids and polyunsaturated fatty acids in platelet phospholipid membranes, which may be a hallmark for a changed level of biologically active compounds required for the activation of future platelets. PMID: 31448759 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 27, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Retracted: Cardioprotective Effect of Isosorbide Dinitrate Postconditioning Against Rat Myocardial Ischemia-Reperfusion Injury In Vivo.
Authors: Zhao X, Wang M, Li M, Wu N, Song D Abstract The Fig 4C and 4D are the same, but the author showed them as two parallel groups. Reference: Cardioprotective Effect of Isosorbide Dinitrate Postconditioning Against Rat Myocardial Ischemia-Reperfusion Injury In Vivo Xinwen Zhao, Mengjuan Wang, Mei Li, Na Wu, Dalin Song Med Sci Monit 2019;25: 1629-1636 10.12659/MSM.912814. PMID: 31449500 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 27, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Micro-Computed Tomography (Micro-CT) Evaluation of Effects of Different Rotary Glide Path Techniques on Canal Transportation and Centering in Curved Root Canals.
CONCLUSIONS All 3 instrument groups performed very similarly, without significant differences in canal-shaping parameters. Overall, using just PF2 instead of PF 1 and 2 created very similar shaping results, which could reduce the number of instruments needed and the cost of treatment. PMID: 31444318 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 26, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Brilliant Blue G Inhibits Inflammasome Activation and Reduces Disruption of Blood-Spinal Cord Barrier Induced by Spinal Cord Injury in Rats.
CONCLUSIONS BBG administration promoted motor function recovery and alleviated tissue injury, and these effects might be related to the suppression of inflammasomes and the maintenance of BSCB integrity. PMID: 31444877 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 26, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Micro-RNA 205-5p is Involved in the Progression of Gastric Cancer and Targets Phosphatase and Tensin Homolog (PTEN) in SGC-7901 Human Gastric Cancer Cells.
This study aimed to investigate the role of micro-RNA 205-5p (miR-205-5p) in the progression of gastric cancer, and the target of miR-205-5p in human gastric cancer cells in vitro. MATERIAL AND METHODS Expression of miR-205-5p and PTEN in gastric cancer tissue samples and adjacent normal gastric tissue from 35 patients was studied using immunohistochemistry and in situ hybridization. SGC-7901 human gastric cancer cells included a normal control (NC) group, a group transfected with empty vector (Vector), a group treated with miR-205-5p inhibitor (miR-inhibitor), and a group treated with miR-205-5p inhibitor and small interf...
Source: Medical Science Monitor - August 26, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Knowledge and Beliefs of E-Cigarettes Among Physicians in Poland.
CONCLUSIONS Physicians in Poland perceive e-cigarettes as harmful and addictive. Physicians' knowledge about e-cigarettes is mostly based on non-scientific sources, which points out the urgent need to develop national smoking cessation guidelines regulating the issue of e-cigarettes based on scientific evidence. PMID: 31439826 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 25, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Predictors of 30-Day In-Hospital Mortality in Patients Undergoing Urgent Abdominal Surgery Due to Acute Peritonitis Complicated with Sepsis.
Authors: Mačiulienė A, Maleckas A, Kriščiukaitis A, Mačiulis V, Vencius J, Macas A Abstract BACKGROUND Sepsis is a life-threatening condition with high morbidity and mortality rate. Identifying early prediction factors of critical situations in intra-abdominal sepsis patients can help reduce mortality rates. This prospective study was carried out to evaluate the association of technically available factors with 30-day in-hospital mortality. MATERIAL AND METHODS There were 67 intra-abdominal sepsis patients included in the study; patients were observed for 30 days postoperatively. The data was processed u...
Source: Medical Science Monitor - August 25, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Benefits and Risks of Subsection Laminectomy with Pedicle Screw Fixation for Ossification of the Ligamentum Flavum of the Thoracic Spine: A Retrospective Study of 30 Patients.
This study aimed to evaluate the effectiveness of subsection laminectomy with pedicle screw fixation (SLPF) for the treatment of ossification of the ligamentum flavum of the thoracic spine. MATERIAL AND METHODS Thirty patients (age, 40-71 years) with ossification of the ligamentum flavum of the thoracic spine underwent SLPF (13 men, 17 women). Operative time, intraoperative blood loss, preoperative and postoperative change in thoracic kyphosis, and perioperative complications were recorded. The Japanese Orthopedic Association (JOA) score for severity of myelopathy and the American Spinal Injury Association (ASIA) motor and...
Source: Medical Science Monitor - August 25, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Leonurine Exerts Anti-Catabolic and Anti-Apoptotic Effects via Nuclear Factor kappa B (NF- κB) and Mitogen-Activated Protein Kinase (MAPK) Signaling Pathways in Chondrocytes.
CONCLUSIONS The results of this study indicate that leonurine exerts anti-catabolic and anti-apoptotic effects in chondrocytes in vitro via suppression of the NF-kappaB and MAPK signaling pathways. PMID: 31431607 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 23, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Progress of the Anterior Transpedicular Screw in Lower Cervical Spine: A Review.
Authors: Zhang YW, Zeng T, Gao WC, Xiao X, Xiao Y, Chen X, Zhang SL, Deng L Abstract The anterior transpedicular screws (ATPS) fixation is a valuable discovery in the field of lower cervical spine (LCS) reconstruction, as it has the advantages of both anterior and posterior approaches. In recent years, with in-depth research on ATPS fixation related to anatomy, biomechanical tests, and clinical applications, its firm stability and excellent biomechanical properties have been recognized by more and more surgeons. Although ATPS fixation has been gradually applied in clinic settings under the promotion of emerging dis...
Source: Medical Science Monitor - August 23, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Retracted: Phosphorylated Glycogen Synthase Kinase-3 β (GSK-3β) Improves Cognition in Rats with Diabetes-Associated Cognitive Decline.
Retracted: Phosphorylated Glycogen Synthase Kinase-3β (GSK-3β) Improves Cognition in Rats with Diabetes-Associated Cognitive Decline. Med Sci Monit. 2019 Aug 21;25:6291 Authors: Ke B, Lu R, Zhang X Abstract The two pictures of B and C in Figure 3 are the same, but apparently, the author presented them as two groups. Reference: Phosphorylated Glycogen Synthase Kinase-3ß (GSK-3ß) Improves Cognition in Rats with Diabetes-Associated Cognitive Decline Boxi Ke, Rong Lu, Xu Zhang Med Sci Monit 2019;25: 3336-3343 10.12659/MSM.914653. PMID: 31433795 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 23, 2019 Category: Research Tags: Med Sci Monit Source Type: research

SUCO as a Promising Diagnostic Biomarker of Hepatocellular Carcinoma: Integrated Analysis and Experimental Validation.
CONCLUSIONS This study was the first to demonstrate that SUCO was overexpressed in HCC-tissues, and that high expression of SUCO was significantly related to poor overall survival in HCC patients. SUCO might be a potential diagnostic biomarker for HCC patients, which promotes the tumorigenesis and progression of HCC. PMID: 31434866 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 23, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Motor Neuron and Pancreas Homeobox 1 (MNX1) Is Involved in Promoting Squamous Cervical Cancer Proliferation via Regulating Cyclin E.
CONCLUSIONS These findings reveal MNX1 as a novel oncogene of cervical cancer and indicate MNX1 is a promising therapeutic and prognostic biomarker. PMID: 31436258 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 23, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Shexiang Tongxin Dropping Pill Improves Peripheral Microvascular Blood Flow via Cystathionine- γ-Lyase.
CONCLUSIONS STP significantly improved peripheral microcirculation, in which increased CSE expression might be the underlying mechanism. PMID: 31437131 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 23, 2019 Category: Research Tags: Med Sci Monit Source Type: research

SOX18 Affects Cell Viability, Migration, Invasiveness, and Apoptosis in Hepatocellular Carcinoma (HCC) Cells by Participating in Epithelial-to-Mesenchymal Transition (EMT) Progression and Adenosine Monophosphate Activated Protein Kinase (AMPK)/Mammalian Target of Rapamycin (mTOR).
CONCLUSIONS SOX18 downregulation in HCC cells suppressed cell viability and metastasis, induced cell apoptosis and hindered the occurrence and progression of tumor cells by participating in the EMT process and regulating the autophagy signaling pathway AMPK/mTOR. PMID: 31427562 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 22, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Carbon Monoxide Attenuates Lipopolysaccharides (LPS)-Induced Acute Lung Injury in Neonatal Rats via Downregulation of Cx43 to Reduce Necroptosis.
CONCLUSIONS CORM3 attenuates LPS-Induced ALI in neonatal rats and its lung protective effect might be through downregulation of Cx43 to attenuate ERK signaling and ameliorate necroptosis, suggesting CORM3 as a potential therapeutic drug for ALI in neonates. PMID: 31429423 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 22, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Atorvastatin Induces Hepatotoxicity in Diabetic Rats via Oxidative Stress, Inflammation, and Anti-Apoptotic Pathway.
CONCLUSIONS Atorvastatin exerts potentially hepatotoxic effects on diabetic rats by modulating oxidative/antioxidative status, pro-inflammatory cytokine production, and apoptosis inhibition. PMID: 31420530 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 20, 2019 Category: Research Tags: Med Sci Monit Source Type: research

The Potential Effects of Diabetes Mellitus on Liver Fibrosis in Patients with Primary Biliary Cholangitis.
CONCLUSIONS The results of this retrospective, single-center study suggest that DM is associated with more severe liver fibrosis in PBC. Consequently, improved management of DM might alter the prognosis of PBC patients. PMID: 31420961 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 20, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Role of CircRNAs_100395 in Proliferation and Metastases of Liver Cancer.
CONCLUSIONS circ_100395 appears to be a promising therapeutic target for liver cancer. PMID: 31421050 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 20, 2019 Category: Research Tags: Med Sci Monit Source Type: research

LL-37 Exacerbates Local Inflammation in Sepsis-Induced Acute Lung Injury by Preventing Mitochondrial DNA (mtDNA) Degradation-Induced Autophagy.
CONCLUSIONS These data show that LL-37 treatment worsens local inflammation in sepsis-induced acute lung injury by preventing mtDNA degradation-induced autophagy. PMID: 31422413 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 20, 2019 Category: Research Tags: Med Sci Monit Source Type: research

A 5-Gene Prognostic Combination for Predicting Survival of Patients with Gastric Cancer.
CONCLUSIONS We introduce a 5-gene combination that can predict the survival of GC patients and might be an independent prognostic factor in GC. PMID: 31422414 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 20, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Foxp3 ⁺ Treg Cells Are Associated with Pathological Process of Autoimmune Hepatitis by Activating Methylation Modification in Autoimmune Hepatitis Patients.
This study investigated role of Foxp3⁺ regulatory T cells (Treg) and methylation-regulated Tregs in AIH pathological processes. MATERIAL AND METHODS Forty consecutive patients diagnosed with hepatitis were enrolled and divided into a virus hepatitis (n=20) group and an AIH group (n=20). Twenty healthy individuals were assigned to the healthy control group (HC, n=20), Liver function biomarkers were detected on an automatic biochemical analyzer. Serum auto-antibodies were evaluated using immunofluorescence method. Histopathological evaluation was conducted with liver tissues. Treg cells were counted using FACS flow cytomet...
Source: Medical Science Monitor - August 20, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Decreased Expression of Long Non-Coding RNA GMDS Divergent Transcript (GMDS-DT) is a Potential Biomarker for Poor Prognosis of Hepatocellular Carcinoma.
Authors: Wang D, Du X, Bai T, Chen M, Chen J, Liu J, Li L, Li H, Zhang C Abstract BACKGROUND Increasing evidence suggests that long non-coding RNA (lncRNA) is closely related to the development of cancer. The present study investigated the potential predictive value of lncRNA GMDS divergent transcript (GMDS-DT) in the prognosis of patients with hepatocellular carcinoma (HCC) after hepatectomy. MATERIAL AND METHODS GMDS-DT was acquired by microarray data in 3 pairs of M1 and M2 macrophage duplicate samples. Real-time polymerase chain reaction (PCR) was performed to evaluate expression levels of GMDS-DT in liver canc...
Source: Medical Science Monitor - August 20, 2019 Category: Research Tags: Med Sci Monit Source Type: research

The Specific Choice of Transrectal Ultrasound-Guided Prostate Biopsy Scheme Based on Prostate Specific Antigen and Prostate Specific Antigen Density.
Authors: Chen Y, Jiang X, Liu R, Zhang Z, Luo F, Qi S, Xu Y Abstract BACKGROUND Although magnetic resonance imaging (MRI)-targeted biopsy and saturation biopsy can improve the accuracy of prostate biopsy, transrectal ultrasound (TRUS)-guided prostate biopsy is still the cornerstone for diagnosis of prostate cancer. However, it is not clear whether it is necessary to perform the same TRUS-guided biopsy scheme for patients with different prostate specific antigen (PSA) or prostate specific antigen density (PSAD) levels. The purpose of this study was to evaluate the optimal core number for specific suspected prostate ...
Source: Medical Science Monitor - August 20, 2019 Category: Research Tags: Med Sci Monit Source Type: research

MicroRNA-449b-5p Suppresses Proliferation, Migration, and Invasion of Osteosarcoma by Targeting c-Met.
CONCLUSIONS MicroRNA-449b-5p is downregulated in OS, which alleviates the malignant progression of OS by targeting c-Met. PMID: 31425497 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 20, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Low Serum Ionized Calcium, Elevated High-Sensitivity C-Reactive Protein, Neutrophil-Lymphocyte Ratio, and Body Mass Index (BMI) Are Risk Factors for Severe Acute Pancreatitis in Patients with Hypertriglyceridemia Pancreatitis.
Authors: Yu S, Wu D, Jin K, Yin L, Fu Y, Liu D, Zhang L, Yu X, Xu J Abstract BACKGROUND To investigate the clinical characteristics of hypertriglyceridemia pancreatitis (HTGP) and evaluate the correlative risk factors for severe acute pancreatitis (SAP) in HTGP patients. MATERIAL AND METHODS A total of 1005 patients with acute pancreatitis (AP) admitted to Peking Union Medical College Hospital (PUMCH) from 1 Jan 2013 to 1 Aug 2018 were retrospectively reviewed. After screening, we enrolled 159 patients with HTGP and 172 with non-hypertriglyceridemia pancreatitis (NHTGP). We gathered and assessed demographic and blo...
Source: Medical Science Monitor - August 17, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Effect of Smoking and Locations of Dental Implants on Peri-Implant Parameters: 3-Year Follow-Up.
Authors: Mumcu E, Dayan SÇ Abstract BACKGROUND Smoking may be a risk factor for marginal bone loss (MBL) and oral mucosal inflammation surrounding dental implants. This retrospective study evaluated the effects of smoking on dental implants in patients with fixed implant-supported prostheses over a period of 36 months following loading. MATERIAL AND METHODS We assessed 120 patients (68 women, 52 men, ages 19-74 years (mean age: 55.10 years) with 315 implants. Implants were classified according to location in the upper and lower jaws and anterior (placed between canines) or posterior (placed between pre-molar...
Source: Medical Science Monitor - August 17, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Plumbagin Restrains Hepatocellular Carcinoma Angiogenesis by Stromal Cell-Derived Factor (SDF-1)/CXCR4-CXCR7 Axis.
CONCLUSIONS The effect of PL on the SDF-1-CXCR4/CXCR7 axis has become an attractive target for inhibiting angiogenesis in hepatoma cells. Our results provide more evidence for the clinical application of PL as part of traditional Chinese medicine in modern cancer treatment. PMID: 31415486 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 17, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Postoperative Serum Levels of Interleukin-1 β (IL-1β), Interleukin-17 (IL-17), and Tumor Necrosis Factor-α (TNF-α) in Patients Following Hip Replacement Surgery for Traumatic Fractured Femoral Neck: A Retrospective Study.
This study aimed to investigate the clinical significance of postoperative serum levels of interleukin-1ß (IL-1ß), interleukin-17 (IL-17), and tumor necrosis factor-alpha (TNF-alpha) in patients who required hip replacement surgery for traumatic fractured neck of femur. MATERIAL AND METHODS A retrospective study included 180 patients who had hip replacement surgery for traumatic fractured neck of femur and a control group of 100 patients. Differences between the two groups were compared for serum levels of IL-1ß, IL-17, and TNF-alpha, and the Harris Hip Score (HHS) (maximum 100 points) using Pearson's cor...
Source: Medical Science Monitor - August 17, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Gestational Diabetes Mellitus Changes the Metabolomes of Human Colostrum, Transition Milk and Mature Milk.
CONCLUSIONS The metabolic profile of human milk is dynamic throughout the first months of lactation. High levels of amino acids in colostrum and high levels of saturated fatty acids and unsaturated fatty acids in mature milk, which may be critical for neonatal development in the first month of life, were features of both normal and GDM pregnancies. PMID: 31418429 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 17, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Gastric Acid and Pepsin Work Together in Simulated Gastric Acid Inhalation Leading to Pulmonary Fibrosis in Rats.
CONCLUSIONS The study demonstrates that aspiration of gastric contents can cause pulmonary fibrosis, and mixed aspiration of pepsin and gastric fluid can accelerate this process. This study provides strong evidence in support of a potential association between human GERD and IPF. PMID: 31419218 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 17, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Network Pharmacology Identifies the Mechanisms of Action of Shaoyao Gancao Decoction in the Treatment of Osteoarthritis.
CONCLUSIONS A novel approach was developed to systematically identify the mechanisms of the TCM, SGD in OA using network pharmacology analysis. PMID: 31409761 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 16, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Human β-Defensin-2 Improves Hyperoxia-Induced Lung Structural and Functional Injury in Neonatal Rats.
CONCLUSIONS In hyperoxia-induced rat models of BPD, hBD2 promotes alveolarization and improves pulmonary function. The mechanism may contribute in alleviating inflammation response and inhibiting pro-inflammatory factors including IL-1ß, IL-6, and TNF-alpha. PMID: 31411185 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 16, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Irisin Enhances Doxorubicin-Induced Cell Apoptosis in Pancreatic Cancer by Inhibiting the PI3K/AKT/NF- κB Pathway.
CONCLUSIONS Irisin can potentiate the cytotoxicity of doxorubicin in PC cells without increasing cardiotoxicity, possibly through inactivating the PI3K/AKT/NF-kappaB signaling pathway. PMID: 31412018 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 16, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Minimally Invasive Percutaneous Plate Osteosynthesis (MIPPO) Combined with Onionskin-Like Autologous Bone Grafting: A New Technique for Treatment of Tibial Nonunion.
CONCLUSIONS MIPPO technology combined with onionskin bone grafting is an efficient method to treat patients with tibial nonunion, especially for patients with poor soft tissue condition. PMID: 31402352 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 15, 2019 Category: Research Tags: Med Sci Monit Source Type: research