Anticancer Effect of Radix Astragali on Cholangiocarcinoma In Vitro and Its Mechanism via Network Pharmacology.
CONCLUSIONS RA is an active medicinal material that can be developed into a safe and effective multi-targeted anticancer treatment for CCA. PMID: 32246704 [PubMed - as supplied by publisher] (Source: Medical Science Monitor)
Source: Medical Science Monitor - April 6, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Pulmonary High-Resolution Computed Tomography (HRCT) Findings of Patients with Early-Stage Coronavirus Disease 2019 (COVID-19) in Hangzhou, China.
CONCLUSIONS The imaging manifestations of early-stage COVID-19 are relatively mild, and the imaging findings of some patients are not typical, which can easily lead to missed diagnoses. Thus, suspected cases need to be closely monitored, and epidemiological history and clinical laboratory examination should also be considered during diagnosis. PMID: 32246819 [PubMed - as supplied by publisher] (Source: Medical Science Monitor)
Source: Medical Science Monitor - April 6, 2020 Category: Research Tags: Med Sci Monit Source Type: research

A Retrospective Population Study to Develop a Predictive Model of Prediabetes and Incident Type 2 Diabetes Mellitus from a Hospital Database in Japan Between 2004 and 2015.
CONCLUSIONS A prognostic model based on six variables was predictive for incident type 2 diabetes mellitus and prediabetes in a healthy population in Japan. PMID: 32235819 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - April 4, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Magnetic Resonance Imaging versus Computed Tomography for Biliary Tract Intraductal Papillary Mucinous Neoplasm (BT-IPMN): A Diagnostic Performance Analysis.
CONCLUSIONS MRI appears to be a more accurate and reliable method than CT for depicting BT-IPMN. PMID: 32235820 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - April 4, 2020 Category: Research Tags: Med Sci Monit Source Type: research

An Integrated Microarray Analysis Reveals Significant Diagnostic and Prognostic Biomarkers in Pancreatic Cancer.
CONCLUSIONS These 7 DEGs might be potential diagnostic and prognostic biomarkers for PAC and help uncovering the mechanism of PAC. PMID: 32235821 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - April 4, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Connection between SOX7 Expression and  Breast Cancer Prognosis.
Connection between SOX7 Expression and Breast Cancer Prognosis. Med Sci Monit. 2020 Apr 02;26:e921510 Authors: Qin CX, Yang XQ, Zhan ZY Abstract BACKGROUND SOX7 exerts a repressing effect against tumors and imposes vital influences on malignancies. Our research discussed the importance of SOX7 in breast cancer prognoses. MATERIAL AND METHODS SOX7 mRNA expression in breast cancer tissues samples and matched adjacent normal controls of breast cancer patients was measured by quantitative real-time-polymerase chain reaction (qRT-PCR). The relationship of SOX7 with clinicopathological characteristics w...
Source: Medical Science Monitor - April 4, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Identification of Potential Therapeutic Targets and Pathways of Liraglutide Against Type 2 Diabetes Mellitus (T2DM) Based on Long Non-Coding RNA (lncRNA) Sequencing.
CONCLUSIONS In this study, we screened 104 lncRNA therapeutic targets and several signaling pathways (Wnt, PPAR, amino acid metabolism signaling pathway, mTOR, and lipid metabolism-related pathways) of liraglutide against T2DM based on lncRNA sequencing. PMID: 32238798 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - April 4, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Effects of Dapagliflozin and Sitagliptin on Insulin Resistant and Body Fat Distribution in Newly Diagnosed Type 2 Diabetic Patients.
This study was an open-label, parallel controlled study. Patients were included if they were newly diagnosed with type 2 diabetes (
Source: Medical Science Monitor - April 4, 2020 Category: Research Tags: Med Sci Monit Source Type: research

A Network Pharmacology Study on the Mechanisms of the Herbal Extract, Christina Loosestrife, for the Treatment of Nephrolithiasis.
CONCLUSIONS Network pharmacology analysis of the herbal extract, Christina Loosestrife, identified multiple active compounds, targets, and pathways involved in the effects on nephrolithiasis. PMID: 32241963 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - April 4, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Long Non-Coding RNA (lncRNA) SNHG5 Participates in Vertical Sleeve Gastrectomy for Type II Diabetes Mellitus by Regulating TGR5.
CONCLUSIONS By downregulating expression of the SNHG5 gene and then altering expression of the TGR5 gene, the damage to colorectal cells induced by high glucose was alleviated. This may be one of the mechanisms underlying the effect of sleeve gastric surgery in treatment of diabetes mellitus. PMID: 32242546 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - April 4, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Sufficient Lumbar Lateral Recess Decompression Acquired by Undercutting "Superior Articular Process Neck" Plus Intervertebral Disk Annuloplasty in Percutaneous Transforaminal Endoscopic Surgery.
Sufficient Lumbar Lateral Recess Decompression Acquired by Undercutting "Superior Articular Process Neck" Plus Intervertebral Disk Annuloplasty in Percutaneous Transforaminal Endoscopic Surgery. Med Sci Monit. 2020 Apr 03;26:e921119 Authors: Liu X, Peng Y, Pei L, Zhu Y Abstract BACKGROUND Percutaneous transforaminal endoscopic surgery has been used as a surgical measure for lumbar lateral recess stenosis. However, the necessary decompressive range has never been clearly documented in detail. Here, we discuss the effectiveness of a percutaneous transforaminal endoscopic procedure with clearly ...
Source: Medical Science Monitor - April 4, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Recanalization of Embolized Endovascular Intracranial Aneurysms and Changes in the Blood Viscosity: A Pilot Study.
Authors: Morga R, Moskała M, Popiela T, Rajzer M, Wilk A, Kłosiński M, Muszyński T, Trystuła M Abstract BACKGROUND The purpose of our research was to evaluate the relationships between blood viscosity and recanalization of coiled intracranial aneurysms. MATERIAL AND METHODS The study included consecutives patients treated endovascularly by a team of experienced neurosurgeons and neuroradiologists due to brain aneurysm. A total of 50 patients (the average age was 57.48 years, SD=13.71) were assigned to 2 groups: group A with recanalization (4 male and 8 female patients) and group B without recanalization (10 ma...
Source: Medical Science Monitor - April 3, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Bioinformatics Analysis of Prognostic Tumor Microenvironment-Related Genes in the Tumor Microenvironment of Hepatocellular Carcinoma.
CONCLUSIONS This study offers a novel 2-gene signature to predict overall survival of patients with HCC, which has the potential to be used as an independent prognostic predictor. Overall, this study reveals more details about the tumor microenvironment in HCC and offers novel candidate biomarkers. PMID: 32231177 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - April 3, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Ibudilast, a Phosphodiesterase-4 Inhibitor, Ameliorates Acute Respiratory Distress Syndrome in Neonatal Mice by Alleviating Inflammation and Apoptosis.
CONCLUSIONS IBU, a PDE4 inhibitor, protected against ARDS by interfering with pulmonary inflammation and apoptosis. Our findings provide a novel and promising strategy to regulate pulmonary inflammation in ARDS. PMID: 32231178 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - April 3, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Propofol Improves Sensitivity of Lung Cancer Cells to Cisplatin and Its Mechanism.
CONCLUSIONS Our report indicated that propofol could control lung cancer cell proliferation and apoptosis, and stimulated the suppression function of DDP on lung cancer cell multiplication via the Wnt/ß-catenin signaling pathway, and also provided a new treatment for DDP tolerance to cure lung cancer in clinical. PMID: 32225124 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - April 1, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Emerging Roles of Blood-Borne Intact and Respiring Mitochondria as Bidirectional Mediators of Pro- and Anti-Inflammatory Processes.
Authors: Esch T, Stefano GB, Ptacek R, Kream RM Abstract Over the past two decades, a major goal of our research group has been elucidation of the functional roles of several key regulatory molecules in proinflammatory preconditioning involved in the pathophysiology of seemingly diverse human disease states. By necessity, operational definitions of proinflammation must be intrinsically fluid based on recent advances in our understanding of complex regulation of innate and adaptive immune processes. Similar to systemic acute stress, a physiological proinflammatory state appears to be a key autoregulatory mechanism f...
Source: Medical Science Monitor - April 1, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Controlled Release of Oxycodone as an Opioid Titration for Cancer Pain Relief: A Retrospective Study.
Authors: Zhao S, Xu C, Lin R Abstract BACKGROUND In 2014, a Chinese expert consensus was proposed regarding a titration protocol with controlled-release (CR) oxycodone as a background dose for relieving the moderate to severe cancer pain. This work aimed to summarize its efficacy and safety in our hospital. MATERIAL AND METHODS The Good Pain Management (GPM) protocol comprises a CR morphine or oxycodone given every 12-hours as a background dose and an immediate-release (IR) opioid as a rescue dose. Cancer patients with moderate to severe cancer pain were treated with this protocol, and the successful titration (num...
Source: Medical Science Monitor - April 1, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Quercetin Inhibits the Proliferation and Metastasis of Human Non-Small Cell Lung Cancer Cell Line: The Key Role of Src-Mediated Fibroblast Growth Factor-Inducible 14 (Fn14)/ Nuclear Factor kappa B (NF- κB) pathway.
CONCLUSIONS Que exerted the anti-NSCLC effect by inhibiting Src-mediated Fn14/NF-kappaB pathway both in vitro and in vivo. PMID: 32225128 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - April 1, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Treatment of Brain Edema by Wogonoside Is Associated with Inhibition of Neuronal Apoptosis and SIRT1 Activation in Rats.
CONCLUSIONS The present study demonstrated that wogonoside prevents brain edema development and apoptosis of neurons in rats by promoting SIRT1 expression and suppression of p53 activation. Therefore, wogonoside has therapeutic potential for the treatment of edema and needs to be investigated further to completely define the mechanism involved. PMID: 32221271 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - March 31, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Injury and Apoptosis in the Palatopharyngeal Muscle in Patients with Obstructive Sleep Apnea-Hypopnea Syndrome.
This study aimed to elucidate the possible activity of the mitochondrial-mediated apoptotic pathway (MMAP) in obstructive sleep apnea-hypopnea syndrome (OSAHS). MATERIAL AND METHODS A control group, a mild OSAHS group, a moderate OSAHS group, and a severe OSAHS group were included. Masson staining, hematoxylin and eosin staining, and terminal deoxynucleotidyl transferase dUTP nick-end labeling (TUNEL) assay were performed to assess collagen fiber hyperplasia, pathological morphology, and cell apoptosis, respectively, in muscle samples. RESULTS In the OSAHS groups, the palatopharyngeal muscle fibers were larger, with appare...
Source: Medical Science Monitor - March 31, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Intravitreal Injection of Human Retinal Progenitor Cells for Treatment of Retinal Degeneration.
CONCLUSIONS Our findings show that intravitreal injection of hRPCs is effective and safe in protecting photoreceptor cells in RCS rats, but were no longer effective at 12 weeks after transplantation. Moreover, hRPCs released multiple neurotrophic factors that may be involved in treating retinal disease. PMID: 32221273 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - March 31, 2020 Category: Research Tags: Med Sci Monit Source Type: research

The Study of Subthalamic Deep Brain Stimulation for Parkinson Disease-Associated Camptocormia.
This study trial was registered in Chinese Clinical Trial Registry (No. ChiCTR1900022655). All the participants provided written informed consent. RESULTS After DBS surgery, all of study patients' symptoms were improved, with different levels of improvement. The minimum and maximum improvement rates were 20% and 100% respectively. The score of item 3.13 of the MDS-UPDRS III and the degree of camptocormia were found to be obviously improved (P
Source: Medical Science Monitor - March 31, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Long Noncoding RNA DANCR Suppressed Lipopolysaccharide-Induced Septic Acute Kidney Injury by Regulating miR-214 in HK-2 Cells.
CONCLUSIONS Our study suggests that AKI development could be alleviated by sponging miR-214 and regulating KLF6 expression, which provides a novel potential mechanism involved in the diagnosis and treatment of sepsis-induced AKI patients. PMID: 32222722 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - March 31, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Long Non-Coding RNA Metastasis Associated Lung Adenocarcinoma Transcript 1 (MALAT1) Promotes Hypertension by Modulating the Hsa-miR-124-3p/Nuclear Receptor Subfamily 3, Group C, Member 2 (NR3C2) and Hsa-miR-135a-5p/NR3C2 Axis.
This study was designed to investigate the role of long non-coding RNA (lncRNA) metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) in the proliferation as well as apoptosis of human umbilical vein endothelial cells (HUVECs), to offer a basis for therapy of hypertension. MATERIAL AND METHODS The lncRNA MALAT1 expression, hsa-miR-124-3p, hsa-miR-135a-5p, hsa-miR-135b-5p, and hsa-miR-455-5p in plasma were measured from 230 patients with hypertension and 230 non-hypertensive controls. The mechanism for lncRNA MALAT1 modulating the proliferation and apoptosis of HUVECs was explored by cell transfection, Cell Counti...
Source: Medical Science Monitor - March 31, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Estrogen Receptors (ESRs) Mutations in Adolescent Idiopathic Scoliosis: A Cross-Sectional Study.
CONCLUSIONS Potential pathogenic variants in ESR1 and ESR2 were identified in 113 AIS patients, suggesting that genetic mutations in ESR1/2 were associated with the risk of AIS. PMID: 32218412 [PubMed - as supplied by publisher] (Source: Medical Science Monitor)
Source: Medical Science Monitor - March 30, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Hydroxypyridinone-Coumarin Inhibits the Proliferation of MHCC97 and HepG2 Human Hepatocellular Carcinoma Cells and Down-Regulates the Phosphoinositide-3 Kinase Pathway.
This study aimed to investigate the effect of hydroxypyridinone-coumarin (HPC) on MHCC97 and HepG2 human HCC cells and the mechanisms involved. MATERIAL AND METHODS MHCC97 and HepG2 human HCC cells were cultured in vitro. An MTT cytotoxicity assay was used to assess cell viability and proliferation, with and without treatment with HPC. Cell autophagosomes were labeled with GFP-LC3 using confocal fluorescence microscopy. Western blot was used to measure protein expression. RESULTS HPC significantly reduced the cell proliferation rate in a concentration-dependent manner, with 2 µM of HPC resulting in a reduced prolifer...
Source: Medical Science Monitor - March 30, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Effect of HtrA1 Polymorphism on Sensitivity to Chemotherapy in Patients with Colon Cancer.
CONCLUSIONS HtrA1 rs1049331 polymorphism, but not rs11200638 polymorphism, can influence individual sensitivity to 5-FU-based treatment in stage III colon cancer patients. PMID: 32218415 [PubMed - as supplied by publisher] (Source: Medical Science Monitor)
Source: Medical Science Monitor - March 30, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Association Between EphA1 and Tumor Microenvironment in Gastric Carcinoma and its Clinical Significance.
CONCLUSIONS EphA1 can promote the occurrence and development of GC by its selective high expression in cancer tissues and its relationship with malignant clinical features and prognosis of GC patients. The underlying potential mechanism appears to involve enhancement of the tumor microenvironment, which via drives the expression of tumor microenvironment hallmark proteins IL-6 and VEGF. PMID: 32218416 [PubMed - as supplied by publisher] (Source: Medical Science Monitor)
Source: Medical Science Monitor - March 30, 2020 Category: Research Tags: Med Sci Monit Source Type: research

An Integrated Network Analysis of mRNA and Gene Expression Profiles in Parkinson's Disease.
CONCLUSIONS DEGs, including SORT1, CRYAB, PSMA1, and SDHA may have roles in the pathogenesis of PD through the MAPK, Wnt, and Notch signaling pathways. PMID: 32210219 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - March 28, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Impact of Interferon-alpha1b (IFN- α1b) on Antitumor Immune Response: An Interpretation of the Promising Therapeutic Effect of IFN-alpha1b on Melanoma.
CONCLUSIONS IFN-alpha1b has an immunostimulatory activity similar to IFN-alpha2b and possesses milder adverse effects on immune checkpoints and stronger inhibitory effects on melanoma cell growth than IFN-alpha2b. Therefore, IFN-alpha1b is a promising drug for the treatment of melanoma. PMID: 32210221 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - March 28, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Comparison of Transfemoral Cerebral Angiography and Transradial Cerebral Angiography Following a Shift in Practice During Four Years at a Single Center in China.
Authors: Ge B, Wei Y Abstract BACKGROUND Cerebral angiography, or intra-arterial digital subtraction angiography (DSA), is a fluoroscopic imaging technique. In China, until recently, transfemoral access (TFA) has been used, rather than transradial access (TRA). This retrospective study aimed to compare transfemoral cerebral angiography (TFCA) with transradial cerebral angiography (TRCA) consecutively performed by the same operator, at a single center in China, to determine whether there were benefits from the shift from TFA to TRA in terms of efficiency, safety, and feasibility. MATERIAL AND METHODS A review of 1,0...
Source: Medical Science Monitor - March 28, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Risk Factors for Recurrent L5-S1 Disc Herniation After Percutaneous Endoscopic Transforaminal Discectomy: A Retrospective Study.
Authors: Yu C, Zhan X, Liu C, Liao S, Xu J, Liang T, Zhang Z, Chen J Abstract BACKGROUND This retrospective study aimed to investigate the risk factors associated with the recurrence of L5-S1 disc herniation after percutaneous endoscopic transforaminal discectomy (PETD). MATERIAL AND METHODS There were 484 patients L5-S1 disc herniation who underwent PETD who were divided into the recurrence group (n=46) and the non-recurrence group (n=438). Transforaminal endoscopic approaches included modifications of the Yeung endoscopy spine system (YESS) (the intraforaminal intradiscal approach) and the transforaminal endoscop...
Source: Medical Science Monitor - March 28, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Effects of a Matrix Metalloproteinase Inhibitor-Eluting Stent on In-Stent Restenosis.
CONCLUSIONS Use of GM6001-eluting stents resulted in persistent and potent inhibition of intimal hyperplasia, an increase in luminal area, and no obvious thrombosis in the arteries of the mini-pigs. PMID: 32214058 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - March 28, 2020 Category: Research Tags: Med Sci Monit Source Type: research

RNA-Sequencing, Connectivity Mapping, and Molecular Docking to Investigate Ligand-Protein Binding for Potential Drug Candidates for the Treatment of Wilms Tumor.
CONCLUSIONS RNA-sequencing, connectivity mapping, and molecular docking to investigate ligand-protein binding identified retinoic acid and alsterpaullone as potential drug candidates for the treatment of Wilms tumor. PMID: 32214060 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - March 28, 2020 Category: Research Tags: Med Sci Monit Source Type: research

An Animal Study of Implantation of an Esophageal Pacemaker Based on Per-Oral Endoscopic Myotomy Approach for Alleviation of Esophageal Peristalsis Disorders.
CONCLUSIONS From this small-sample, short follow-up animal study, it was found that the implantation of esophageal electrodes and pacemaker based on POEM and NOTES is feasible, safe, and effective. Nevertheless, there is urgent need for long-term follow-up to confirm or disprove the safety of the procedure. PMID: 32214061 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - March 28, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Secreted Phosphoprotein 1 (SPP1) and Fibronectin 1 (FN1) Are Associated with Progression and Prognosis of Esophageal Cancer as Identified by Integrated Expression Profiles Analysis.
CONCLUSIONS Our analysis is the first to show that SPP1 and FN1 might work as biological markers of progression and prognosis in esophageal carcinoma (ESCA). PMID: 32208405 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - March 27, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Long Noncoding RNA (lncRNA) Maternally Expressed Gene 3 (MEG3) Participates in Chronic Obstructive Pulmonary Disease through Regulating Human Pulmonary Microvascular Endothelial Cell Apoptosis.
CONCLUSIONS Our study illustrated a protective effect of lncRNA MEG3-shRNA on CSE-induced HPMECs, indicting lncRNA MEG3 can be a new therapeutic approach for COPD treatment. PMID: 32201430 [PubMed - indexed for MEDLINE] (Source: Medical Science Monitor)
Source: Medical Science Monitor - March 25, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Effects of Lower Trapezius Strengthening Exercises on Pain, Dysfunction, Posture Alignment, Muscle Thickness and Contraction Rate in Patients with Neck Pain; Randomized Controlled Trial.
This study examined the effects of a lower trapezius exercise program on neck pain patients. MATERIAL AND METHODS The design of this study was a randomized controlled trial. A total of 40 neck pain patients participated in this study. Screening tests were performed and assigned to experimental group (n=20) and control group (n=20) using randomization program. Both groups underwent a scapula and thoracic spine stabilization exercise program. In addition, the experimental group implemented the lower trapezius strengthening exercise program. All interventions were applied 3 times per week for 4 weeks. Visual Analogue Scale (V...
Source: Medical Science Monitor - March 25, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Does Exposure to Computed Tomography Contrast Media Increase Risk of End-Stage Renal Disease?
CONCLUSIONS The use of CECT increased the risk of ESRD 1.2-fold in advanced and stable CKD outpatients after 5-year follow-up. PMID: 32203057 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - March 25, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Rhubarb and Astragalus Capsule Attenuates Renal Interstitial Fibrosis in Rats with Unilateral Ureteral Obstruction by Alleviating Apoptosis through Regulating Transforming Growth Factor beta1 (TGF- β1)/p38 Mitogen-Activated Protein Kinases (p38 MAPK) Pathway.
CONCLUSIONS RAC can improve the renal interstitial fibrosis induced by UUO, and the mechanism may be related to inhibition of renal tubular cell apoptosis via TGF-ß1/p38 MAPK pathway. PMID: 32205836 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - March 25, 2020 Category: Research Tags: Med Sci Monit Source Type: research

PIK3C3 Acts as a Tumor Suppressor in Esophageal Squamous Cell Carcinoma and Was Regulated by MiR-340-5p.
CONCLUSIONS MiR-340-5p functioned as an oncogene of ESCC by directly binding and repressing the expression of PIK3C3. PMID: 32207410 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - March 25, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Identification of Hub Genes in Hepatocellular Carcinoma Related to Progression and Prognosis by Weighted Gene Co-Expression Network Analysis.
CONCLUSIONS Our findings revealed that these 4 genes can be regarded as potential prognosticators and therapeutic targets for HCC. PMID: 32200387 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - March 24, 2020 Category: Research Tags: Med Sci Monit Source Type: research

A New Nomogram Allowing Physicians to Predict Patients at High Risk of Fever Occurring After Prostate Biopsy.
CONCLUSIONS This is the first study to develop a nomogram to predict fever after prostate biopsy via Biopsy-positive rate (BPR), Hematuria, and Urine WBC. Use of this nomogram might help prevent fever and infection, and could facilitate individualized medical treatment after prostate biopsy. PMID: 32200388 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - March 24, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Nanotechnology Strategies for the Analysis of Circulating Tumor DNA: A Review.
Authors: Chen X, Wang L, Lou J Abstract Circulating tumor DNA (ctDNA) describes the fragmented DNA released from tumor cells into the blood. The ctDNA may have the same genetic changes as the primary tumor. Currently, ctDNA has become a popular biomarker for diagnosis, treatment, real-time clinical response monitoring, and prognosis, for solid tumors. Detection of ctDNA is minimally invasive, and repeat sampling can easily be performed. However, due to its low quality and short DNA fragment length, ctDNA detection still faces challenges and requires highly sensitive analytical techniques. Recently, liquid biopsies ...
Source: Medical Science Monitor - March 24, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Lidocaine Reduces Sevoflurane Consumption and Improves Recovery Profile in Children Undergoing Major Spine Surgery.
CONCLUSIONS Lidocaine treatment decreases sevoflurane consumption and improves recovery profiles in children undergoing major spine surgery. PMID: 32198342 [PubMed - as supplied by publisher] (Source: Medical Science Monitor)
Source: Medical Science Monitor - March 22, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Systemic Analysis of the Prognosis-Related RNA Alternative Splicing Signals in Melanoma.
CONCLUSIONS AS events could be ideal indicators for SKCM prognosis. The key feature gene MCF2L played an important role in wild-type SKCM. PMID: 32199022 [PubMed - as supplied by publisher] (Source: Medical Science Monitor)
Source: Medical Science Monitor - March 22, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Down-Regulation of Fibroblast Growth Factor 2 (FGF2) Contributes to the Premature Senescence of Mouse Embryonic Fibroblast.
CONCLUSIONS The premature senescence of MEFs was at least partially caused by FGF2 deficiency. Exogenous FGF2 could alleviate the senescent phenotype. PMID: 32188838 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - March 21, 2020 Category: Research Tags: Med Sci Monit Source Type: research

A Modified Suture Technique in Hepaticojejunostomy.
Authors: Li G, Yuan L, Yu G, Xu Y, Liu J Abstract BACKGROUND Hepaticojejunostomy is a common biliary reconstruction procedure in hepatobiliary surgery. The suture technique plays a key role in the procedure. The conventional suture technique is complex and time-consuming. To facilitate the procedure, we performed it with a modified suture technique. In the present study, we evaluated the efficacy and safety of the technique in hepaticojejunostomy. MATERIAL AND METHODS We enrolled 120 adult patients who underwent hepaticojejunostomy. The patients were divided into a conventional group and a modified suture group acc...
Source: Medical Science Monitor - March 21, 2020 Category: Research Tags: Med Sci Monit Source Type: research

The p66shc-mediated Regulation of Hepatocyte Senescence Influences Hepatic Steatosis in Nonalcoholic Fatty Liver Disease.
CONCLUSIONS Our findings indicated that the increase in hepatocyte senescence and steatosis in NAFLD may be caused by the upregulation of p66shc expression, implying that strategies for p66shc-mediated regulation of hepatocyte senescence may provide new therapeutic tools for NAFLD. PMID: 32191680 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - March 21, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Experimental Study of Somatic Variants of Osteosarcoma by Whole-Exome Sequencing.
CONCLUSIONS The gene analysis confirmed that patients with osteosarcoma had a wide range of common gene mutations related to each other, which are involved in tumor-related metabolic pathways. These findings provide a basis for further gene-targeted therapy and pathway research. PMID: 32193367 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - March 21, 2020 Category: Research Tags: Med Sci Monit Source Type: research