Curcumin Suppresses Apoptosis and Inflammation in Hypoxia/Reperfusion-Exposed Neurons via Wnt Signaling Pathway.
CONCLUSIONS Curcumin exerted neuro-protective effects against H/R-induced neuron apoptosis and inflammation by inhibiting activation of the Wnt/JNK1 signaling pathway. PMID: 32107363 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - March 1, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Synaptotagmin 12 (SYT12) Gene Expression Promotes Cell Proliferation and Progression of Lung Adenocarcinoma and Involves the Phosphoinositide 3-Kinase (PI3K)/AKT/Mammalian Target of Rapamycin (mTOR) Pathway.
CONCLUSIONS Bioinformatics analysis, human LUAD cells, and mouse xenograft studies showed that SYT12 acted as a possible oncogene by phosphorylation of PIK3R3 to activate the PI3K/AKT/mTOR signaling pathway. PMID: 32108133 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - March 1, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Analysis of Risk Factors for Anorectal Stenosis of Perianal Fistulizing Crohn's Disease.
CONCLUSIONS Higher CDAI and older age at diagnosis appear to confer higher risk of anorectal stenosis associated with PFCD. PMID: 32109226 [PubMed - as supplied by publisher] (Source: Medical Science Monitor)
Source: Medical Science Monitor - March 1, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Assessment of Acute Pulmonary Embolism by Computer-Aided Technique: A Reliability Study.
This study aimed to evaluate the reliability of geometry-based computer-aided detection and quantification for emboli morphology and severity of acute pulmonary embolism. MATERIAL AND METHODS Thirty patients suspected of acute pulmonary embolism were analyzed by both manual and computer-aided interpretation of vascular obstruction index and computer-aided measurements of emboli quantitative parameters. The reliability of Qanadli and Mastora scores was analyzed using computer-aided and manual interpretation. RESULTS The time costs of manual and computer-aided interpretation were statistically different (374.90±150.16...
Source: Medical Science Monitor - March 1, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Regenerative Potential of Menstrual Blood-Derived Stem Cells and Platelet-Derived Growth Factor in Endometrial Injury.
CONCLUSIONS These results suggest that MenSCs and PDGF may be candidate substances for endometrial injury repair. PMID: 32112554 [PubMed - as supplied by publisher] (Source: Medical Science Monitor)
Source: Medical Science Monitor - March 1, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Dihydrotanshinone I Alleviates Spinal Cord Injury via Suppressing Inflammatory Response, Oxidative Stress and Apoptosis in Rats.
CONCLUSIONS In conclusion, the findings suggest that DI alleviates SCI by restraining secretion of inflammatory factors, and occurrence of oxidative stress and apoptosis in vivo. DI may be developed into an effective alternative therapy for SCI in clinic. PMID: 32112706 [PubMed - as supplied by publisher] (Source: Medical Science Monitor)
Source: Medical Science Monitor - March 1, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Association of Obesity Measures with Atrial Fibrillation Recurrence After Cryoablation in Patients with Paroxysmal Atrial Fibrillation.
This study explored the relationship between various obesity indexes and risk of recurrence after cryoablation of paroxysmal AF (PAF). MATERIAL AND METHODS Our prospective study included 100 patients with PAF who underwent first cryoablation. Physical examination and fasting blood lipids levels were measured at baseline. Seven obesity indexes were determined: body mass index (BMI), waist circumference (WC), waist-to-height ratio (WHtR), waist-hip ratio (WHR), cardiometabolic index (CMI), lipid accumulation product (LAP), and body adiposity index (BAI). AF recurrence was confirmed by electrocardiograms and Holter monitor at...
Source: Medical Science Monitor - February 29, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Construction for Long Non-Coding RNA (lncRNA)-Associated Competing Endogenous RNA (ceRNA) Network in Human Retinal Detachment (RD) with Proliferative Vitreoretinopathy (PVR).
Authors: Yao K, Yu Y, Zhang H Abstract BACKGROUND The aim of this study was to analyze the long non-coding RNA (lncRNA)-associated competing endogenous RNA (ceRNA) network in human retinal tissues following detachment with proliferative vitreoretinopathy (PVR). MATERIAL AND METHODS Expression data of 19 human detached retinas with PVR and 19 normal retinas from postmortem donors were downloaded from Gene Expression Omnibust (GEO) database (GSE28133). The R package "limma" was utilized to discriminate the dysregulated lncRNA and mRNA profiles. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes ...
Source: Medical Science Monitor - February 29, 2020 Category: Research Tags: Med Sci Monit Source Type: research

The Comparison of the Biological Rhythms of Patients with Fibromyalgia Syndrome with Biological Rhythms of Healthy Controls.
Authors: Bulbul F, Koca I, Savas E, Dokuyucu R Abstract BACKGROUND Fibromyalgia syndrome (FMS) is a rheumatic disease characterized by diffuse body pain and decreased muscle function. The aim of the present study was to compare the biological rhythms of patients with fibromyalgia syndrome with the biological rhythms of healthy controls. MATERIAL AND METHODS This was a cross-sectional, single blind, and single center case-control study. The patients with fibromyalgia were evaluated using a Fibromyalgia Impact Questionnaire (FIQ), Biological Rhythms Interview of Assessment in Neuropsychiatry (BRIAN) Scale, Visual Ana...
Source: Medical Science Monitor - February 27, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Intermittent Splenic Artery Occlusion Plus Gauze Compression Is a Simple and Effective Treatment for Iatrogenic Splenic Injury.
CONCLUSIONS Intermittent splenic artery occlusion plus gauze compression is a simple and effective treatment for iatrogenic splenic injury. PMID: 32096484 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - February 27, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Economic Analysis of Surgical and Interventional Treatments for Patients with Complex Coronary Artery Disease: Insights from a One-Year Single-Center Study.
Authors: Zhao Y, Meng S, Liu T, Dong R Abstract BACKGROUND Surgical treatment methods for patients with complex coronary artery disease (CAD) who have undergone vascular reconstruction mainly include coronary artery bypass graft (CABG) and percutaneous coronary intervention (PCI). The purpose of the study aimed to compare a 1-year follow-up for the patient clinical outcomes and costs between PCI and CABG treatment. MATERIAL AND METHODS There were 840 patients enrolled in this study from July 2015 to September 2016. Among the study participants, 420 patients underwent PCI treatment and 420 patients underwent off-pum...
Source: Medical Science Monitor - February 27, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Identification and Validation of a Potent Multi-miRNA Signature for Prediction of Prognosis of Osteosarcoma Patients.
CONCLUSIONS The 3-miRNA-based classifier serves as an effective prognosis-predicting signature for osteosarcoma patients. PMID: 32098942 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - February 27, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Emergent Double Balloon Enteroscopy in Overt Suspected Small Bowel Bleeding: Diagnosis and Therapy.
Authors: Yin A, Zhao L, Ding Y, Yu H Abstract BACKGROUND Double balloon enteroscopy (DBE) is a diagnosis and therapy method for suspected small bowel bleeding (SSBB). The data for emergent DBE is limited in overt SSBB cases. The aim of this study was to investigate the role of diagnosis and therapy of emergent DBE in patients with overt SSBB. MATERIAL AND METHODS The clinical and endoscopic data for patients with overt SSBB undergoing DBE in a single center from January 2010 to December 2017 were collected and analyzed. Emergent DBE was defined as DBE performed less than 3 days of last bleeding onset. RESULTS A tot...
Source: Medical Science Monitor - February 27, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Correlation Between Sex and Facial Soft Tissue Characteristics Among Young Saudi Patients with Various Orthodontic Skeletal Malocclusions.
Authors: Ajwa N, Alkhars FA, AlMubarak FH, Aldajani H, AlAli NM, Alhanabbi AH, Alsulaiman SA, Divakar DD Abstract BACKGROUND There is a debate over the influence of sex on facial soft tissue physiognomies. Therefore, the present study used teleradiographs to assess and compare the soft tissue physiognomies between males and females in a sample from Saudi Arabia who have various orthodontic malocclusions. MATERIAL AND METHODS We obtained 221 lateral cephalometric radiographs taken from orthodontic clinics of patients ages 16-26 years (114 males and 107 females) living in the central and eastern regions of Saudi Arab...
Source: Medical Science Monitor - February 27, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Immune Response of Plasmacytoid Dendritic Cells Stimulated by Human Papillomavirus (HPV) E6 in an In Vitro System.
CONCLUSIONS The expression of MyD88 and TRAF6 might vary in different stages of HPV infection. pDCs might regulate CD40 to participate in the tumorigenesis and progression of cervical cancer, but related mechanisms still need further investigation. PMID: 32089541 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - February 26, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Angiogenic Factor with G Patch and FHA Domains 1 (AGGF1) Acts as Diagnostic Biomarker and Adverse Prognostic Factor of Hepatocellular Carcinoma (HCC): Evidence from Bioinformatic Analysis.
CONCLUSIONS AGGF1 was a potential diagnostic and prognostic marker for poor clinical outcomes in HCC patients. Moreover, vital pathways regulated by AGGF1 in HCC may include regulation of autophagy, Wnt signaling pathway, pathway in cancer, cell cycle, and P53 signaling pathway. PMID: 32090983 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - February 26, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Effect of Pressure-Controlled Ventilation-Volume Guaranteed on One-Lung Ventilation in Elderly Patients Undergoing Thoracotomy.
CONCLUSIONS Compared with VCV, PCV-VG mode reduced airway pressure in patients undergoing thoracotomy and also decreased the release of NE and reduced inflammatory response and lung injury. We conclude that PCV-VG mode can protect the lung function of elderly patients undergoing thoracotomy. PMID: 32092047 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - February 26, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Relationship of CARD8 Gene Polymorphisms with Susceptibility to Ankylosing Spondylitis: A Case-Control Study.
CONCLUSIONS CARD8 polymorphisms are likely to be associated with the elevated susceptibility of AS. Present results should be confirmed in the future studies. PMID: 32080163 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - February 24, 2020 Category: Research Tags: Med Sci Monit Source Type: research

A Network Pharmacology Approach to Estimate the Active Ingredients and Potential Targets of Cuscutae semen in the Treatment of Osteoporosis.
CONCLUSIONS This study suggested that CS has multiple ingredients and multiple targets relevant to the treatment of osteoporosis. We determined that the active ingredient, sesamin, may be the most crucial ingredient of CS for the treatment of osteoporosis. Additionally, the network pharmacology method provided a novel research approach to analyze the function of complex ingredients. PMID: 32081843 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - February 24, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Overexpression of Bone Morphogenetic Protein-1 Promotes Osteogenesis of Bone Marrow Mesenchymal Stem Cells In Vitro.
CONCLUSIONS Our results suggest that the overexpression of BMP-1 can promote the osteogenesis of BMSCs and provides an improved method of cell-based tissue engineering. PMID: 32084123 [PubMed - as supplied by publisher] (Source: Medical Science Monitor)
Source: Medical Science Monitor - February 24, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Comparative Evaluation of Two Antioxidants on Reversing the Immediate Bond Strength of Bleached Enamel: In Vitro Study.
CONCLUSIONS 10% sodium ascorbate provided a comparatively more promising improvement for immediate bond strength than 5% proanthocyanidins when the same duration of antioxidant was applied. PMID: 32086431 [PubMed - as supplied by publisher] (Source: Medical Science Monitor)
Source: Medical Science Monitor - February 24, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Expression and Prognostic Significance of m6A-Related Genes in Lung Adenocarcinoma.
CONCLUSIONS m6A-related genes were differentially expressed in LUAD compared to matched normal patients. The m6A-related genes METTL3, YTHDF1, and YTHDF2 could serve as novel biomarkers for the prognosis of LUAD. PMID: 32086933 [PubMed - as supplied by publisher] (Source: Medical Science Monitor)
Source: Medical Science Monitor - February 24, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Maternal Characteristics and Obstetric and Neonatal Outcomes of Singleton Pregnancies Among Adolescents.
CONCLUSIONS In conclusion, our findings indicate that along with considerably high rates of poor antenatal care, maternal anemia and cesarean delivery, adolescent pregnancies were also associated with high rates for fetal distress at birth, preterm delivery, and NICU re-admission within post-discharge 1-month. PMID: 32087083 [PubMed - as supplied by publisher] (Source: Medical Science Monitor)
Source: Medical Science Monitor - February 24, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Retracted: Modified Closing-Opening Wedge Osteotomy to Correct Kyphosis in Ankylosing Spondylitis.
Authors: Feng C, Tao H, Yang K, Xu J, Duan C, Yang W, Li H, Li H Abstract An Editorial decision has been made to retract the manuscript, Feng C, et al. Modified Closing-Opening Wedge Osteotomy to Correct Kyphosis in Ankylosing Spondylitis. Med Sci Monit. 2019; 25:6532-6538. It has come to our attention that the method of modified closing opening wedge osteotomy is not an original procedure developed by the authors, but has previously been described by Boissière L, et al. Spine J. 2015;15(12):2574-82, and Gao R, et al. Spine J. 2015;15(9):2009-15, and Boachie-Adjei O, et al. Spine (Phila Pa 1976). 2006;31(4):...
Source: Medical Science Monitor - February 24, 2020 Category: Research Tags: Med Sci Monit Source Type: research

High Expression of Methylenetetrahydrofolate Dehydrogenase 2 (MTHFD2) in Esophageal Squamous Cell Carcinoma and its Clinical Prognostic Significance.
Authors: He H, Li PC, Jia W, Hu B, Ji CS Abstract BACKGROUND Recently, targeted therapy for malignant tumors has developed rapidly, but there is still no effective targeted therapy for advanced esophageal squamous cell carcinoma (ESCC). Methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) is a key enzyme involved in folate metabolism and is closely related to the proliferation in many cancers. However, few studies have explored the expression of MTHFD2 in ESCC and its prognostic significance. MATERIAL AND METHODS The expressions of MTHFD2, ki67, and p53 in ESCC tissues were detected by immunohistochemistry. Further, ...
Source: Medical Science Monitor - February 24, 2020 Category: Research Tags: Med Sci Monit Source Type: research

A Nomogram for Individual Prediction of Poor Prognosis After Radical Surgery in Patients with Primary Pancreatic Duct Adenocarcinoma.
CONCLUSIONS Our study presents a valid and practical model to predict prognosis of pancreatic cancer patients, which contributes to individualized therapy by assisting surgeons to predict poor prognosis in patients who received radical surgery. PMID: 32088726 [PubMed - as supplied by publisher] (Source: Medical Science Monitor)
Source: Medical Science Monitor - February 24, 2020 Category: Research Tags: Med Sci Monit Source Type: research

RNA Binding Protein RNPC1 Suppresses the Stemness of Human Endometrial Cancer Cells via Stabilizing MST1/2 mRNA.
CONCLUSIONS Therefore, our results indicate a novel RNPC1/MST1/2 signaling responsible for EC cell stemness. PMID: 32088727 [PubMed - as supplied by publisher] (Source: Medical Science Monitor)
Source: Medical Science Monitor - February 24, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Correlation Between von Hippel-Lindau Gene Expression and Tumor SUVmax and Survival Prognosis in Hepatocellular Carcinoma.
Authors: Li G, Shen Y, Wang F, Hong S, Cai M Abstract BACKGROUND We investigated the relationship between the 18F-FDG PET/CT metabolic parameter SUVmax in primary hepatocellular carcinoma (HCC) and expression of von Hippel-Lindau (VHL), as well as its effect on HCC survival prognosis. MATERIAL AND METHODS We retrospectively analyzed data for 62 HCC patients who received 18F-FDG PET/CT before surgery at the First Affiliated Hospital of Bengbu Medical College from June 2013 to June 2018 (42 males, 20 females; median age 62 years). No treatment was performed prior to the examination. The relationship between preoperat...
Source: Medical Science Monitor - February 22, 2020 Category: Research Tags: Med Sci Monit Source Type: research

LOC101060264 Silencing Suppresses Invasion and Metastasis of Human Colon Cancer.
CONCLUSIONS In summary, LOC101060264 silencing decreased LoVo cell invasiveness via suppressing ETM and attenuated tumor metastasis, which provides a novel therapeutic target for patients with colon cancer. PMID: 32077446 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - February 22, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Antimicrobial Efficacy of Different Decontamination Methods as Tested on Dental Implants with Various Types of Surfaces.
CONCLUSIONS The results of our study suggest that the method of implant decontamination should be customized to the type of implant surface. PMID: 32078588 [PubMed - as supplied by publisher] (Source: Medical Science Monitor)
Source: Medical Science Monitor - February 22, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Circular RNA-0001283 Suppresses Breast Cancer Proliferation and Invasion via MiR-187/HIPK3 Axis.
CONCLUSIONS The results reveal a new functional circRNA-0001283 in breast cancer and may provide targets for developing novel therapeutic strategies for breast cancer. PMID: 32066649 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - February 20, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Usefulness of a Nurse-Led Program of Care for Management of Patients with Chronic Heart Failure.
Authors: You J, Wang S, Li J, Luo Y Abstract BACKGROUND The aims of the present study were to determine whether a nurse-led program of care can improve medication adherence, quality of life (QoL), rates of rehospitalization, and all-cause mortality for chronic heart failure (CHF) patients. MATERIAL AND METHODS CHF patients were randomly assigned into either a control group or an intervention group. At 12 weeks, patients were followed up to evaluate the rate of medication adherence, QoL (as assessed by SF-12 physical and mental component score [PCS and MCS]), rehospitalization, and all-cause mortality. RESULTS We re...
Source: Medical Science Monitor - February 20, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Altered Dynamic Neural Activity in the Default Mode Network in Lung Cancer Patients After Chemotherapy.
CONCLUSIONS The current study indicated that patients with lung cancer after CTx had decreased dynamic brain activity in the DMN region, and the DMN is vulnerable when patients undergoing CTx. PMID: 32069270 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - February 20, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Role of Ca ²⁺ in Inhibiting Ischemia-Induced Apoptosis of Parathyroid Gland Cells in New Zealand White Rabbits.
CONCLUSIONS This study demonstrates that calcium supplementation inhibited the apoptosis of parathyroid cells following ischemic injury. PMID: 32071284 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - February 20, 2020 Category: Research Tags: Med Sci Monit Source Type: research

miRNA-411 Regulates Chondrocyte Autophagy in Osteoarthritis by Targeting Hypoxia-Inducible Factor 1 alpha (HIF-1 α).
CONCLUSIONS Our results demonstrate that miR-411 promotes chondrocyte autophagy by targeting HIF-1alpha, suggesting that regulating HIF-1alpha by miR-411 might be a therapeutic strategy for OA. PMID: 32072994 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - February 20, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Development of a Nomogram for Predicting Blood Transfusion Risk After Hemiarthroplasty for Femoral Neck Fractures in Elderly Patients.
CONCLUSIONS We found a correlation between blood transfusion requirement and low preoperative Hb, longer time to surgery, general anesthesia, longer surgery duration, and higher IBL, and we then developed a nomogram. Our nomogram model can be used to evaluate the transfusion risk for FNF patients after HA, and provides better guidance for clinicians to intervene perioperatively, so as to reduce the incidence of blood transfusion. PMID: 32074099 [PubMed - as supplied by publisher] (Source: Medical Science Monitor)
Source: Medical Science Monitor - February 20, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Effects of Hetiao Jianpi Decoction on Intestinal Injury and Repair in Rats with Antibiotic-Associated Diarrhea.
CONCLUSIONS By improving the permeability and immune function of the intestinal mucosa, Hetiao Jianpi decoction prevented the occurrence of AAD by repairing the intestinal mucosal damage and regulating the structure and diversity of intestinal flora. PMID: 32062668 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - February 19, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Association Between Cystatin C and Cardiac Function and Long-Term Prognosis in Patients with Chronic Heart Failure.
Authors: Wu X, Xu G, Zhang S Abstract BACKGROUND The aim of this study was to investigate the association between cystatin C and cardiac function and long-term prognosis in patients with chronic heart failure (CHF). MATERIAL AND METHODS We selected 418 CHF patients admitted to our hospital as subjects. Patients were divided into 3 groups according to the cystatin C level (Quantile 1 group: 0.65-1.04 mg/L, Quantile 2 group: 1.05-1.35 mg/L, and Quantile 3 group: 1.36-7.84 mg/L), and patients were followed up for 5 years. We used odds ratio (OR) and 95% confidence interval (CI) to compare the results. RESULTS The cyst...
Source: Medical Science Monitor - February 19, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Efficacy of Oxaliplatin/5-Fluorouracil/Capecitabine-Cetuximab Combination Therapy and Its Effects on K-Ras Mutations in Advanced Colorectal Cancer.
Authors: Wei L, Chen J, Wen J, Wu D, Ma X, Chen Z, Huang J Abstract BACKGROUND The aim of this study was to perform an accurate exploration on the efficacy of oxaliplatin/5-fluorouracil/capecitabine-cetuximab combination therapy and its effects on K-Ras mutations in advanced colorectal cancer. MATERIAL AND METHODS Among 96 patients who suffered metastatic colorectal cancer without mutated K-Ras, 41 patients who were receiving treatment with oxaliplatin/5-fluorouracil/capecitabine and administered cetuximab as the initial treatment comprised the observation group; the remaining 55 patients receiving cetuximab as an ...
Source: Medical Science Monitor - February 19, 2020 Category: Research Tags: Med Sci Monit Source Type: research

The Effects of Inositol Metabolism in Pregnant Women on Offspring in the North and South of China.
Authors: Wang X, Yue H, Li S, Guo J, Guan Z, Qin J, Zhu Z, Niu B, Cui M, Wang J Abstract BACKGROUND Inositol is an essential nutrient for cell growth, survival and embryonic development. Myo-inositol is the predominant form in natural. To investigate the correlation between inositol metabolism and embryonic development, we assessed the metabolic characteristics of myo-inositol, phosphatidylinositol 4,5-bisphosphate (PI(4,5)P₂) and phosphatidylinositol 3,4,5-trisphosphate (PI(3,4,5)P₃) of pregnant women in the North China (Yangquan and Weihai) and South China (Nanchang and Haikou) China. MATERIAL AND METHODS All...
Source: Medical Science Monitor - February 19, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Huai Qi Huang Potentiates Dexamethasone-Mediated Lethality in Acute Lymphoblastic Leukemia Cells by Upregulating Glucocorticoid Receptor α.
CONCLUSIONS HQH enhanced the sensitivity of ALL cells to glucocorticoids by increasing the expression of GRalpha and inhibiting the MEK/ERK pathway, thus providing a rational foundation for the treatment of ALL with HQH. PMID: 32065117 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - February 19, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Total Flavonoid Extract from Hawthorn (Crataegus pinnatifida) Improves Inflammatory Cytokines-Evoked Epithelial Barrier Deficit.
CONCLUSIONS TFH can alleviate TNF-alpha-evoked intestinal epithelial barrier deficit via the NFkappaBp65-mediated MLCK-MLC signaling pathway. PMID: 32065826 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - February 19, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Impact of Sevoflurane Versus Propofol Anesthesia on Post-Operative Cognitive Dysfunction in Elderly Cancer Patients: A Double-Blinded Randomized Controlled Trial.
CONCLUSIONS Sevoflurane-based anesthesia did not increase the incidence of POCD compared to propofol-based anesthesia at 7 days or 3 months post-operation or impact short-term post-operative prognosis. PMID: 32060257 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - February 17, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Network Pharmacology-Based Prediction and Verification of Qingluo Tongbi Formula to Reduce Liver Toxicity of Tripterygium wilfordii via UGT2B7 in Endoplasmic Reticulum.
CONCLUSIONS The Chinese traditional medicine compound QTF can achieve the effect of detoxification by upregulating the expression of UGT2B7 in the endoplasmic reticulum. PMID: 32061080 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - February 17, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Inhibition of MiR-122 Decreases Cerebral Ischemia-reperfusion Injury by Upregulating DJ-1-Phosphatase and Tensin Homologue Deleted on Chromosome 10 (PTEN)/Phosphonosinol-3 Kinase (PI3K)/AKT.
CONCLUSIONS Inhibition of miR-122 can decrease cerebral ischemia-reperfusion injury by upregulating DJ-1-PTEN/PI3K/AKT pathway. PMID: 32061171 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - February 17, 2020 Category: Research Tags: Med Sci Monit Source Type: research

GANT61 and Valproic Acid Synergistically Inhibited Multiple Myeloma Cell Proliferation via Hedgehog Signaling Pathway.
CONCLUSIONS GANT61 and valproic acid inhibited multiple myeloma cell proliferation synergistically by inhibiting the Hedgehog signaling pathway. The present study may provide a combination regime for the therapy of multiple myeloma. PMID: 32054823 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - February 16, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Long Noncoding RNA X-Inactive Specific Transcript (XIST) Promotes Osteogenic Differentiation of Periodontal Ligament Stem Cells by Sponging MicroRNA-214-3p.
CONCLUSIONS XIST participates in osteogenic differentiation of PDLSCs by sponging miR-214-3p. PMID: 32057034 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - February 16, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Identification of Hub Genes and Pathways in Gastric Adenocarcinoma Based on Bioinformatics Analysis.
CONCLUSIONS This research distinguished hub genes and relevant signal pathways, which contributes to our understanding of the molecular mechanisms, and could be used as diagnostic indicators and therapeutic biomarkers for gastric adenocarcinoma. PMID: 32058995 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - February 16, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Management of Infected Bone Defects of the Lower Extremities by Three-Stage Induced Membrane Technique.
CONCLUSIONS TSIMT is effective in treating infected bone defects of the lower extremities. Advanced age, longer duration of infected bone defects, active smoking, and external fixation adversely affect bone union and recovery of infected extremities in a limited time span. PMID: 32047141 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - February 14, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Deficiency of Interleukin-36 Receptor Protected Cardiomyocytes from Ischemia-Reperfusion Injury in Cardiopulmonary Bypass.
CONCLUSIONS IL-36R deficiency in cardiomyocytes repressed infiltration of bone marrow-derived inflammatory cells and oxidative stress dependent on SIRT1-FOXO1 signaling, thus protecting cardiomyocytes and improving cardiac function in CPB model rats. PMID: 32048631 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - February 14, 2020 Category: Research Tags: Med Sci Monit Source Type: research