Retracted: Ursolic Acid Exhibits Potent Anticancer Effects in Human Metastatic Melanoma Cancer Cells (SK-MEL-24) via Apoptosis Induction, Inhibition of Cell Migration and Invasion, Cell Cycle Arrest, and Inhibition of Mitogen-Activated Protein Kinase (MAPK)/ERK Signaling Pathway.
Authors: Liu P, Du R, Yu X Abstract Retraction of this publication has been requested by the authors due to problems with reproducibility. Reference: Pengcheng Liu, Ruili Du, Xin Yu. Ursolic Acid Exhibits Potent Anticancer Effects in Human Metastatic Melanoma Cancer Cells (SK-MEL-24) via Apoptosis Induction, Inhibition of Cell Migration and Invasion, Cell Cycle Arrest, and Inhibition of Mitogen-Activated Protein Kinase (MAPK)/ERK Signaling Pathway Med Sci Monit 2019; 25:1283-1290. 10.12659/MSM.913069. PMID: 33452230 [PubMed - as supplied by publisher] (Source: Medical Science Monitor)
Source: Medical Science Monitor - January 18, 2021 Category: Research Tags: Med Sci Monit Source Type: research

Evaluation of 3-Dimensional Magnetic Resonance Imaging (3D MRI) in Diagnosing Anterior Talofibular Ligament Injury.
This study aimed to evaluate the accuracy of 3D MRI and compare it with 2D MRI in diagnosing ATFL injury. MATERIAL AND METHODS This was a prospective study in which 45 patients with clinically suspected ATFL injury underwent 2D MRI, 3D MRI, and 3D model reconstruction followed by arthroscopic surgery between February 2018 and April 2019. Two radiologists who had over 11 and 13 years of musculoskeletal experience assessed the injury of ATFL in consensus without any clinical clues. Arthroscopic surgery results were the standard reference of MRI accuracy. RESULTS The 3D MRI results of ATFL injury showed the sensitivity of dia...
Source: Medical Science Monitor - January 18, 2021 Category: Research Tags: Med Sci Monit Source Type: research

Comparison of Rocuronium with Succinylcholine for Rapid Sequence Induction Intubation in the Emergency Department: A Retrospective Study at a Single Center in China.
CONCLUSIONS The findings from this study support results from previous studies, showing that even in the Emergency Department setting, rocuronium was equivalent to succinylcholine in achieving rapid sequence induction intubation, when the dose was appropriate. However, as current clinical guidelines highlight, succinylcholine has more contraindications and adverse effects, including hyperkalemia, which should be monitored, and rocuronium has a longer duration of action. PMID: 33441534 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - January 16, 2021 Category: Research Tags: Med Sci Monit Source Type: research

Mechanical Stress Affects Circadian Rhythm in Skeletal Muscle (C2C12 Myoblasts) by Reducing Per/Cry Gene Expression and Increasing Bmal1 Gene Expression.
CONCLUSIONS Our study revealed that mechanical stress loading affected circadian rhythm in skeletal muscle (C2C12 myoblasts) through reducing Per/Cry and enhancing Clock/Bmal1 gene expression. This study provides insights for investigating circadian rhythm and associated bio-functions of humans. PMID: 33444293 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - January 16, 2021 Category: Research Tags: Med Sci Monit Source Type: research

Alterations in Cerebral Hemodynamics During Microgravity: A Literature Review.
Authors: Du J, Cui J, Yang J, Wang P, Zhang L, Luo B, Han B Abstract Most reported neurological symptoms that happen after exposure to microgravity could be originated from alterations in cerebral hemodynamics. The complicated mechanisms involved in the process of hemodynamics and the disparate experimental protocols designed to study the process may have contributed to the discrepancies in results between studies and the lack of consensus among researchers. This literature review examines spaceflight and ground-based studies of cerebral hemodynamics and aims to summarize the underlying physiological mechanisms tha...
Source: Medical Science Monitor - January 16, 2021 Category: Research Tags: Med Sci Monit Source Type: research

Wide-Field Fluorescein Angiography in the Diagnosis and Management of Retinal Vein Occlusion: A Retrospective Single-Center Study.
CONCLUSIONS Decision-making about management of patients with RVO should be done after physical examination and analysis of central and peripheral retina FA. In 20.6% of patients, assessment of the peripheral retina resulted in a change in treatment. The first changes suggestive of progression of thrombotic disease to the ischemic form appeared on the periphery in images from WF-FA. PMID: 33449920 [PubMed - as supplied by publisher] (Source: Medical Science Monitor)
Source: Medical Science Monitor - January 16, 2021 Category: Research Tags: Med Sci Monit Source Type: research

Systems Pharmacology-Based Identification of Mechanisms of Action of Bolbostemma paniculatum for the Treatment of Hepatocellular Carcinoma.
CONCLUSIONS The PI3K/Akt, HIF1, p53, and PPAR pathways may play vital roles in TBM treatment of HCC. Also, the potential anti-cancer effect of TBM on HCC appears to stem from the synergetic effect of multiple targets and mechanisms. PMID: 33436534 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - January 15, 2021 Category: Research Tags: Med Sci Monit Source Type: research

Analysis of Root Canal Curvature and Root Canal Morphology of Maxillary Posterior Teeth in Guizhou, China.
Authors: Qiao X, Xu T, Chen L, Yang D Abstract BACKGROUND We investigated the root canal curvature and morphology of maxillary posterior teeth in Guizhou, China, to provide references for clinical practice. MATERIAL AND METHODS We collected 274 maxillary posterior teeth in Guizhou Province, China. The root canal curvature was observed by X-ray film measurement. Two hundred teeth were selected to make transparent tooth models, and root canal configuration was recorded according to Vertucci classification criteria. The position of the MB2 root canal orifice and the mesiobuccal root canal configuration were observed b...
Source: Medical Science Monitor - January 15, 2021 Category: Research Tags: Med Sci Monit Source Type: research

Limb-Salvage Outcomes of Arterial Repair Beyond Time Limit at Different Lower-Extremity Injury Sites.
CONCLUSIONS Although limited recanalization of blood vessels may lead to limb complications or amputations over time, the high success rate of limb salvage still merits the surgeon's best efforts. PMID: 33431786 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - January 13, 2021 Category: Research Tags: Med Sci Monit Source Type: research

Lumbar Sympathetic Nerve Modulation Using Absolute Ethanol for the Treatment of Primary Lower-Extremity Hyperhidrosis: A Dose-Effect Pilot Study.
Authors: Liu M, Ni H, Tao J, Xie K Abstract BACKGROUND Primary lower-extremity hyperhidrosis (PLEH) can be treated by CT-guided lumbar sympathetic nerve modulation using absolute ethanol. However, doses of ethanol that are too high can cause nerve injury, and doses that are too low have suboptimal results. The present study aimed to investigate the dose-effect relationship of CT-guided lumbar sympathetic nerve modulation with absolute ethanol for PLEH. MATERIAL AND METHODS The study was conducted at the First Affiliated Hospital of Jiaxing University between 07/2014 and 02/2017. Twenty participants were enrolled in...
Source: Medical Science Monitor - January 13, 2021 Category: Research Tags: Med Sci Monit Source Type: research

Personality Traits, Stress, and Emotional Intelligence Associated with Central Serous Chorioretinopathy.
CONCLUSIONS A higher level of perceived stress is the most important psychological risk factor for CSCR. According to our results, a low level of emotional intelligence may be an additional factor that contributes to the occurrence of CSCR. PMID: 33423036 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - January 12, 2021 Category: Research Tags: Med Sci Monit Source Type: research

Magnetic Resonance Imaging has Better Accuracy in Detecting New-Onset Rib Fractures as Compared to Computed Tomography.
CONCLUSIONS MRI is highly sensitive for new-onset rib fractures, especially type I, so it is a preferred method for patients with mild chest trauma. PMID: 33424019 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - January 12, 2021 Category: Research Tags: Med Sci Monit Source Type: research

Lightwand-Guided Insertion of Flexible Reinforced Laryngeal Mask Airway: Comparison with Standard Digital Manipulation Insertion.
CONCLUSIONS Lightwand-guided f-LMA insertion showed a better fiberoptic laryngeal view than standard digital manipulation, but no improvement in the ventilatory state was observed due to position. Therefore, lightwand-guided insertion could facilitate correct placement of the f-LMA, but it has limited clinical usefulness. PMID: 33428608 [PubMed - as supplied by publisher] (Source: Medical Science Monitor)
Source: Medical Science Monitor - January 12, 2021 Category: Research Tags: Med Sci Monit Source Type: research

Plasma Heat Shock Protein 90 Alpha: A Valuable Predictor of Early Chemotherapy Effectiveness in Advanced Non-Small-Cell Lung Cancer.
This study aimed to investigate the association of HSP90a with chemotherapy in advanced NSCLC. MATERIAL AND METHODS We retrospectively evaluated data from patients admitted to the Department of Respiratory Medicine, Shaoxing People's Hospital, from September 2016 to September 2018 with stage IIIB or IV NSCLC and administered 4 cycles of third-generation platinum-based combination chemotherapy (2 drugs simultaneously). Based on the RECIST1.1 criteria, complete remission (CR), partial response (PR), and stable disease (SD) in 60 cases were determined before and after chemotherapy. Before chemotherapy and after 1, 2, and 4 cy...
Source: Medical Science Monitor - January 11, 2021 Category: Research Tags: Med Sci Monit Source Type: research

Therapeutic Effect of an Anti-Human Programmed Death-Ligand 1 (PD-L1) Nanobody on Polymicrobial Sepsis in Humanized Mice.
CONCLUSIONS KN035, an anti-PD-L1 antibody, can improve the rate of survival in CLP mice and alleviate sepsis-induced apoptosis in the spleen. PMID: 33421049 [PubMed - as supplied by publisher] (Source: Medical Science Monitor)
Source: Medical Science Monitor - January 11, 2021 Category: Research Tags: Med Sci Monit Source Type: research

Comparison of CellSearch and Circulating Tumor Cells (CTC)-Biopsy Systems in Detecting Peripheral Blood Circulating Tumor Cells in Patients with Gastric Cancer.
CONCLUSIONS The CTC-Biopsy system was superior to the CellSearch system for detecting CTCs in GC patients. CTM were detected with the CTC-Biopsy system but not with the CellSearch system. CTCs detected with the CellSearch system correlated with various clinicopathological factors and long-term survival outcomes. PMID: 33408319 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - January 9, 2021 Category: Research Tags: Med Sci Monit Source Type: research

Efficacy of 5-Aminolevulinic Acid (ALA)-Photodynamic Therapy (PDT) in Refractory Vulvar Lichen Sclerosus: Preliminary Results.
The objective parameters, female sexual function index (FSFI) and quality of life (QoL) scores, were used before and after treatment to evaluate the clinical curative effect. RESULTS All patients completed 3 treatment cycles of ALA-PDT and follow-up visits. The clinical symptoms of pruritus completely disappeared in 27 cases, and itching improved from severe to mild in 3 cases. The pathological changes of all patients were objectively improved. FSFI score decreased significantly after treatment (P
Source: Medical Science Monitor - January 9, 2021 Category: Research Tags: Med Sci Monit Source Type: research

Respiratory Variations in Peak Peripheral Artery Velocities and Waveforms for Rapid Assessment of Fluid Responsiveness in Traumatic Shock Patients.
This study aimed to assess the correlation between the variability of the end-inspiratory and end-expiratory blood flow waveform and fluid responsiveness (FR) in traumatic shock patients who underwent mechanical ventilation by evaluating peripheral arterial blood flow parameters. MATERIAL AND METHODS A cohort of 60 patients with traumatic shock requiring mechanical ventilation-controlled breathing received ultrasound examinations to assess the velocity of carotid artery (CA), femoral artery (FA) and brachial artery (BA). A rehydration test was performed in which of 250 mL of 0.9% saline was administered within 30 min betwe...
Source: Medical Science Monitor - January 9, 2021 Category: Research Tags: Med Sci Monit Source Type: research

Trends in Workplace Violence Involving Health Care Professionals in China from 2000 to 2020: A Review.
We describe China's past and current clinical practices and health care policies, and we discuss the challenges faced by medical professionals who are victims of hospital-based violence from the perspectives of patients, physicians, hospital leaders, and the government. We conclude by making recommendations for preventing violence in hospital settings. It is urgent for the public to understand that the occupational safety of health care workers must be protected, and treatment should be provided to patients in a harmonious and safe environment. This review aims to describe the trends in workplace violence involving health ...
Source: Medical Science Monitor - January 9, 2021 Category: Research Tags: Med Sci Monit Source Type: research

Secondary Effects of the Rupture and Reconstruction of the Interosseous Talocalcaneal Ligament on the Peritalar Joints.
CONCLUSIONS An ITCL resection can lead to the progressive degeneration of the talonavicular and posterior subtalar joints, while an ITCL reconstruction can be beneficial in restoring the stability of these joints, preventing or postponing their degeneration, and protecting the articular cartilages. PMID: 33402662 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - January 8, 2021 Category: Research Tags: Med Sci Monit Source Type: research

Sinomenine Improves Embryo Survival by Regulating Th1/Th2 Balance in a Mouse Model of Recurrent Spontaneous Abortion.
CONCLUSIONS SIN treatment demonstrates a therapeutic effect on spontaneous abortion in RSA mice, possibly through regulating the balance of Th1/Th2 in maternal circulation and decidual tissues. PMID: 33390585 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - January 6, 2021 Category: Research Tags: Med Sci Monit Source Type: research

Effect of Parecoxib Sodium on Myocardial Ischemia-Reperfusion Injury Rats.
Authors: Wu F, Wang W, Duan Y, Guo J, Li G, Ma T Abstract BACKGROUND We aimed to explore the effect of parecoxib sodium on myocardial ischemia-reperfusion (I/R) injury rats and its mechanism. MATERIAL AND METHODS The coronary artery of Sprague-Dawley rats was occluded for 6 h of myocardial ischemia, followed by reperfusion for 30 min (I/R group). Before ischemia, parecoxib sodium (10 mg/kg) was intraperitoneally injected twice a day for 3 consecutive days, followed by reperfusion for 6 h (I/R+Pare group). The cardiac function and changes in the infarction area were evaluated via echocardiography in each group. The ...
Source: Medical Science Monitor - January 6, 2021 Category: Research Tags: Med Sci Monit Source Type: research

Utility of Magnetic Resonance Imaging in Diagnosis of Prenatal Non-Visualization of the Fetal Gallbladder: A Case-Series Study.
CONCLUSIONS MRI contributes to identifying PNVGB detected or suspected by ultrasonography. PMID: 33397840 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - January 6, 2021 Category: Research Tags: Med Sci Monit Source Type: research

Co-Infection with Common Respiratory Pathogens and SARS-CoV-2 in Patients with COVID-19 Pneumonia and Laboratory Biochemistry Findings: A Retrospective Cross-Sectional Study of 78 Patients from a Single Center in China.
CONCLUSIONS The findings showed that Mycoplasma pneumonia and respiratory syncytial virus were the most common co-infections in patients with COVID-19 pneumonia. Increased levels of PCT in patients with COVID-19 pneumonia were associated with co-infection. PMID: 33388738 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - January 5, 2021 Category: Research Tags: Med Sci Monit Source Type: research

Influenza-Associated Encephalopathy and Acute Necrotizing Encephalopathy in Children: A Retrospective Single-Center Study.
Authors: Song Y, Li S, Xiao W, Shen J, Ma W, Wang Q, Yang H, Liu G, Hong Y, Li P, Yang S Abstract BACKGROUND Although influenza primarily affects the respiratory system, it can cause severe neurological complications, especially in younger children, but knowledge about the early indicators of acute necrotizing encephalopathy (ANE) is limited. The main purpose of this article is to summarize the clinical characteristics, diagnosis, and treatment of neurological complications of influenza in children, and to identify factors associated with ANE. MATERIAL AND METHODS This was a retrospective study of children with con...
Source: Medical Science Monitor - January 5, 2021 Category: Research Tags: Med Sci Monit Source Type: research

Regulatory Effect of PD1/PD-Ligand 1 (PD-L1) on Treg Cells in Patients with Idiopathic Pulmonary Fibrosis.
CONCLUSIONS This work identified the molecular mechanism of PD-1 in patients with IPF. It may provide a new perspective on the therapeutic effect of PD-1. PMID: 33386384 [PubMed - as supplied by publisher] (Source: Medical Science Monitor)
Source: Medical Science Monitor - January 3, 2021 Category: Research Tags: Med Sci Monit Source Type: research

Association Between Thyroid Function and Body Composition in Type 2 Diabetes Mellitus (T2DM) Patients: Does Sex Have a Role?
CONCLUSIONS Thyroid function can affect body composition in euthyroid T2DM patients. Thyroid function is more likely to affect the fat and muscle distribution of males than females. PMID: 33387440 [PubMed - as supplied by publisher] (Source: Medical Science Monitor)
Source: Medical Science Monitor - January 3, 2021 Category: Research Tags: Med Sci Monit Source Type: research

Characterization of the Relationship Between the Expression of Aspartate β-Hydroxylase and the Pathological Characteristics of Breast Cancer.
CONCLUSIONS ASPH may be involved in the development of BC and may have utility as a prognostic biomarker in BC. The coexpression of ASPH-associated genes may also be beneficial in improving BC prognosis. PMID: 33380715 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - January 2, 2021 Category: Research Tags: Med Sci Monit Source Type: research

Piperine Inhibits Cell Proliferation and Induces Apoptosis of Human Gastric Cancer Cells by Downregulating Phosphatidylinositol 3-Kinase (PI3K)/Akt Pathway.
CONCLUSIONS Our findings suggest that piperine inhibits proliferation and induces apoptosis of human gastric cancer cells through inhibition of the PI3K/Akt signaling pathway. PMID: 33382670 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - January 2, 2021 Category: Research Tags: Med Sci Monit Source Type: research

Comparison of Oncoplastic Breast-Conserving Therapy and Standard Breast-Conserving Therapy in Early-Stage Breast Cancer Patients.
CONCLUSIONS OBCT had better cosmetic effects, fewer complications, and no adverse effects on metastasis and recurrence. PMID: 33384404 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - January 2, 2021 Category: Research Tags: Med Sci Monit Source Type: research

A Novel Instant 3-Dimensional Printing System for Postoperative Fracture Patients: A Comparative Cohort Study.
Authors: Chen L, Xiong Y, Mi B, Yan C, Xie X, He Z, Zhou W, Liu G Abstract BACKGROUND Traditional plaster (TP) is a widely used auxiliary fixation (AF) approach for postoperative fracture patients. However, patient discomfort and inconvenience to clinicians has limited its application. We introduce a novel instant 3-dimensional printing appliance system (3D-AS) to address such issues. MATERIAL AND METHODS Twenty-seven postoperative fracture patients were divided randomly between a TP group and a 3D-AS group, and analyzed retrospectively. Radiographic images during follow-up were evaluated for fracture healing and f...
Source: Medical Science Monitor - January 2, 2021 Category: Research Tags: Med Sci Monit Source Type: research

Hypertension Among Hemorrhagic Stroke Patients in Northeast China: A Population-Based Study 2017-2019.
CONCLUSIONS The high prevalence of uncontrolled hypertension and high rates of blood pressure at stages 2 and 3 in patients with prior hemorrhagic stroke indicated a considerable stroke burden in northeast China. Therefore, effective and long-time management of hypertension in stroke survivors should be a priority. PMID: 33376232 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - January 1, 2021 Category: Research Tags: Med Sci Monit Source Type: research

Role of Magnetic Resonance Spectroscopy in Evaluation of Cerebral Metabolic Status Before and After Carotid Endarterectomy/Thromboendarterectomy and Carotid Artery Stenting in Patients with Asymptomatic Critical Internal Carotid Artery Stenosis.
Authors: Sklinda K, Mruk B, Surowiecka A, Ciaś M, Paluch Ł, Andziak P, Walecki J Abstract BACKGROUND The relative efficacy of carotid endarterectomy (CEA)/thromboendarterectomy (TEA) and carotid artery stenting (CAS) already has been compared in randomized controlled trials and a meta-analysis, but only limited data exist describing the status of cerebral metabolism before and after these interventions. The aim of the present study was to compare metabolic changes before and after treatment of carotid stenosis and assess their potential clinical implications.   MATERIAL AND METHODS Patients with asymptomatic...
Source: Medical Science Monitor - January 1, 2021 Category: Research Tags: Med Sci Monit Source Type: research

Retracted: Naturally Occurring Sesquiterpene Lactone-Santonin, Exerts Anticancer Effects in Multi-Drug Resistant Breast Cancer Cells by Inducing Mitochondrial Mediated Apoptosis, Caspase Activation, Cell Cycle Arrest, and by Targeting Ras/Raf/MEK/ERK Signaling Pathway.
Authors: Wu Z, Wang C, Huang M, Tao Z, Yan W, Du Y Abstract It is now clear that the photomicrographs in Figure 2 are duplicates of the same image and that Figures 4 and 5 have been 'copied' from a publication "Lupeol triterpene exhibits potent antitumor effects in A427 human lung carcinoma cells via mitochondrial mediated apoptosis, ROS generation, loss of mitochondrial membrane potential and downregulation of m-TOR/PI3Ksol;AKT signalling pathway" by Wei He, Xiang Li, Shuyue Xia, PMID: 30003730. Because the manuscript contains non-credible results and has also breached copyright, this journal is retracti...
Source: Medical Science Monitor - January 1, 2021 Category: Research Tags: Med Sci Monit Source Type: research

Safety and Efficacy of Therapeutic Erythrocytapheresis Treatment in Chronic Mountain Sickness Patients in Shigatse, Tibet, China.
Authors: Niu M, Singh S, Mi M, Bian P, Deji Z, Mima D, Li X Abstract BACKGROUND Therapeutic erythrocytapheresis (TEA) is a medical technology that separates erythrocytes from whole blood and has been used in various hematological conditions. However, reports on the use of TEA to treat chronic mountain sickness (CMS) are lacking. The aim of the present study was to evaluate the efficacy, safety, and use of TEA in treatment of CMS. MATERIAL AND METHODS A total of 32 patients living in the Shigatse area of Tibet (altitude 4000 m) who had CMS were treated with TEA. Clinical data, CMS score, Borg dyspnea score, 6-min wa...
Source: Medical Science Monitor - December 30, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Comparison of the Clinical Efficacy of 3 Surgical Methods for Treating Spinal Tuberculosis in Children.
CONCLUSIONS Considering the incidence of complications and level of postoperative biochemical indicators, we concluded that caution should be exercised in using an anterior approach to treat pediatric ST. PMID: 33361735 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - December 30, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Expression of the Topoisomerase II Alpha (TOP2A) Gene in Lung Adenocarcinoma Cells and the Association with Patient Outcomes.
This study was carried out to analyze TOP2A expression in lung adenocarcinoma (LUAD) and to assess its value in clinical diagnosis and prognosis. MATERIAL AND METHODS The Cancer Genome Atlas (TCGA) database was used to study the relationship of TOP2A expression with the progression and prognosis of LUAD. For a further elucidation of the value of TOP2A in LUAD, the effect of TOP2A knockout on cell viability and related protein expression of LUAD cell line A549 in vitro was investigated by using RNA interference, MTT, flow cytometry, RT-PCR, and western blot analysis. RESULTS According to the results of database analysis, TO...
Source: Medical Science Monitor - December 30, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Elevated CA-125 Level and ER-Negative as Prognostic Factors for Ovarian Metastasis in Patients with Endometrial Cancer: A Retrospective Cohort Study.
Authors: Ling X, Zheng Z, Xu J, Xu G, Zhou H, Lin Z, Li Y, Liang J, Lu H Abstract BACKGROUND The utility of cancer antigen 125 (CA-125), estrogen receptor (ER), and progesterone receptor (PR) in evaluation for ovarian metastasis of endometrial cancer has yet to be determined. The purpose of this study was to investigate the incidence and the possible risk factors of ovarian metastasis. MATERIAL AND METHODS A retrospective study was performed in endometrial cancer patients who accepted surgical intervention of hysterectomy and oophorectomy during 2002-2013 in Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Ch...
Source: Medical Science Monitor - December 30, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Kinesin Family Member C1 (KIFC1) Regulated by Centrosome Protein E (CENPE) Promotes Proliferation, Migration, and Epithelial-Mesenchymal Transition of Ovarian Cancer.
CONCLUSIONS KIFC1 contributed to cell proliferation, migration, and EMT via interacting with CENPE in ovarian cancer. KIFC1 might be a potential biomarker and therapeutic target in ovarian cancer patients. PMID: 33361741 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - December 30, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Comparison of Second- and Third-Generation Parathyroid Hormone Test Results in Patients with Chronic Kidney Disease.
CONCLUSIONS Correcting for the established quantitative differences, the second-and third-generation PTH tests can be used interchangeably, given the almost identical pathophysiological correlations of their results with calcium-phosphate and bone metabolism parameters. PMID: 33361742 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - December 30, 2020 Category: Research Tags: Med Sci Monit Source Type: research

A Real-World Study of Cerebral 99mTc-TRODAT-1 Single-Photon Emission Computed Tomography (SPECT) Imaging of the Dopamine Transporter in Patients with Parkinson Disease from a Tertiary Hospital in Brazil.
CONCLUSIONS This study demonstrated that brain scintigraphy with the DAT ligand 99mTc-TRODAT-1 may influence diagnostic or therapeutic interventions, meaning that Brazilian physicians who requested the exam have taken in vivo DAT results into account at the time of clinical decision-making. PMID: 33361743 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - December 30, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Effects of Occupational Radiation Exposure on Job Stress and Job Burnout of Medical Staff in Xinjiang, China: A Cross-Sectional Study.
This study sought to investigate the effects of occupational radiation exposure on job stress and job burnout of medical radiation staff. MATERIAL AND METHODS Using cluster random sampling, a total of 1573 medical radiation workers were initially selected from 10 hospitals in Xinjiang, China, and 1396 valid questionnaires were finally collected. Job stress and job burnout were assessed using the Effort-Reward Imbalance (ERI) questionnaire and the Chinese Maslach Burnout Inventory (CMBI), respectively. RESULTS The percentages of medical radiation staff experiencing job stress and job burnout were 53.08% and 63.32%, respecti...
Source: Medical Science Monitor - December 30, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Laryngeal Squamous Cell Carcinoma: Potential Molecular Mechanism and Prognostic Signature Based on Immune-Related Genes.
CONCLUSIONS From the perspective of IRGs, we first constructed an IRDEG signature related to the prognosis of LSCC, which can be used as a novel marker to predict prognosis in patients with LSCC. PMID: 33361747 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - December 30, 2020 Category: Research Tags: Med Sci Monit Source Type: research

A Prognostic Molecular Signature of N ⁶-Methyladenosine Methylation Regulators for Soft-Tissue Sarcoma from The Cancer Genome Atlas Database.
A Prognostic Molecular Signature of N⁶-Methyladenosine Methylation Regulators for Soft-Tissue Sarcoma from The Cancer Genome Atlas Database. Med Sci Monit. 2020 Dec 28;26:e928400 Authors: Hou M, Guo X, Chen Y, Cong L, Pan C Abstract BACKGROUND Soft-tissue sarcomas are a group of heterogeneous and rare mesenchymal tumors with aggressive behavior. We aimed to identify the molecular signatures of N⁶-methyladenosine (m6A) methylation regulators associated with patient prognosis using The Cancer Genome Atlas (TCGA) database. MATERIAL AND METHODS To evaluate the role of m⁶A in soft-tissue sarcomas, gen...
Source: Medical Science Monitor - December 30, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Retrospective Study of Clinical Features of COVID-19 in Inpatients and Their Association with Disease Severity.
Authors: Wang H, Xing Y, Yao X, Li Y, Huang J, Tang J, Zhu S, Zhang Y, Xiao J Abstract BACKGROUND The aim of this study was to analyze the clinical features and laboratory indices of patients with coronavirus disease (COVID-19) and explore their association with the severity of the disease. MATERIAL AND METHODS A total of 61 patients with COVID-19 were divided into groups with common symptoms and with severe diseases, and clinical data were collected to analyze and compare the differences between them. RESULTS In patients with severe COVID-19, compared with the common group, lymphocyte count and albumin levels were...
Source: Medical Science Monitor - December 23, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Urinary Liver-type Fatty Acid-Binding Protein Predicts Residual Renal Function Decline in Peritoneal Dialysis Patients.
Authors: Torigoe K, Muta K, Tsuji K, Yamashita A, Ota Y, Kitamura M, Mukae H, Nishino T Abstract BACKGROUND Liver-type fatty acid-binding protein (L-FABP) is a predictive marker for the early detection of acute kidney injury; however, less is known about how useful it is for predicting residual renal function (RRF) decline in patients on peritoneal dialysis (PD). MATERIAL AND METHODS The study subjects were 35 patients on PD who underwent multiple peritoneal equilibration tests (PETs) between October 2011 and October 2019. Urinary L-FABP levels were analyzed with enzyme-linked immunosorbent assay. The relationship ...
Source: Medical Science Monitor - December 23, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Characteristics and Effectiveness of the Coronavirus Disease 2019 (COVID-19) Prevention and Control in a Representative City in China.
CONCLUSIONS We have provided a successful model to control the transmission of COVID-19 in a short period. PMID: 33349626 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - December 23, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Comparison of Outcomes Following Thyroid Isthmusectomy, Unilateral Thyroid Lobectomy, and Total Thyroidectomy in Patients with Papillary Thyroid Microcarcinoma of the Thyroid Isthmus: A Retrospective Study at a Single Center.
CONCLUSIONS These findings from a single center showed that for patients with PTMC of the thyroid isthmus, who had no comorbidities, there was no significant difference in outcome between the 3 types of thyroid surgery. PMID: 33351790 [PubMed - as supplied by publisher] (Source: Medical Science Monitor)
Source: Medical Science Monitor - December 23, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Effect of Asthma on Erectile Dysfunction in Rats as Determined by Biological Network Analysis.
Authors: Wang J, Gong X, Deng S, Meng F, Dai H, Bao B, Feng J, Li H, Wang B Abstract BACKGROUND We explored the effect of asthma on erectile dysfunction (ED) and the effects of the expression of related proteins. MATERIAL AND METHODS We used a bioinformatics database to predict the targets and pathways associated with asthma and ED. The rat model of asthma was caused by an ovalbumin solution. The number of erections in 30 min was observed by injecting apomorphine into the neck at a dose of 100 μg/kg. Rats with no erection were regarded as the model group (group B), and the previous random 6 normal rats were rega...
Source: Medical Science Monitor - December 22, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Characteristics of Nosocomial Infections in Children Screened for SARS-CoV-2 Infection in China.
CONCLUSIONS For SARS-CoV-2 nosocomial infections, taking a "standard prevention & contact isolation & droplet isolation & air isolation" strategy can prevent infection effectively. Children with clustered disease need close monitoring. PMID: 33335084 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - December 20, 2020 Category: Research Tags: Med Sci Monit Source Type: research