How Grant Success Rates Do (Or Do Not) Track With the NIH Budget: A Model of Funding Dynamics
From 2014 to 2018, the NIH budget increased every year, and yet, the Research Project Grant (RPG) success rate remained relatively constant at ~20%. From 2003 to 2006 the NIH budget remained relatively flat, yet the success rate decreased dramatically from 30% to 20%. Why don’t success rates neatly track the NIH budget? While inflation plays a role, there are more fundamental forces at play.
Here I present a series of budget and success rate scenarios that are largely based on a Service Science publication by Larson, Ghaffarzadegan, and Diaz. The bottom-line up front: NIH funding dynamics are strongly affected by obli...
Source: NIH Extramural Nexus - March 25, 2024 Category: Research Authors: Mike Lauer Tags: blog Open Mike Budget Funding data Source Type: funding
NINDS Advanced Institutional Research Training Program (T32 Clinical Trial Not Allowed)
Funding Opportunity PAR-24-126 from the NIH Guide for Grants and Contracts. The purpose of this FOA is to provide support for institutional research training programs in areas relevant to the NINDS mission. These institutional research training programs should produce well-trained neuroscientists who leave the program with the research skills and scientific knowledge to make a significant contribution to neuroscience research. Programs should be designed to enhance the breadth and depth of training in NINDS mission areas by incorporating didactic, research and career development components in the context of a defined sc...
Source: NIH Funding Opportunities (Notices, PA, RFA) - March 12, 2024 Category: Research Source Type: funding
Limited Competition: Alcohol-associated Hepatitis Clinical Network Integrated Treatment Clinical Trials Data Coordinating Center (U24 - Clinical Trial Required)
Funding Opportunity RFA-AA-24-005 from the NIH Guide for Grants and Contracts. he purpose of this limited competition Notice of Funding Opportunity (NOFO) is to support the Data Coordinating Center of the previously funded program on Late Phase Clinical Trials and Observational Studies in Alcoholic Hepatitis. The existing program of AH Clinical and Translational Network, hereafter termed Alcohol-associated Hepatitis Network, AlcHepNet, has been sponsored by the NIAAA since 2012 and was renewed in 2018. The purpose of this research program is to improve biomedical, psychosocial and quality of life outcomes for patients w...
Source: NIH Funding Opportunities (Notices, PA, RFA) - March 7, 2024 Category: Research Source Type: funding
How Many Researchers: The FY 2023 Cumulative Investigator Rate
We are pleased to share our annual snapshot of how many researchers NIH supports. These fiscal year (FY) 2023 data are also available in the NIH Data Book (see report #303) and represent awards made with traditional and supplemental coronavirus appropriations. Please keep in mind that these data are distinct from success rates, however, which are application-based metrics (see this recent post).
Our cumulative investigator rate is an NIH-wide person-based metric. The metric is calculated as the number of unique principal investigators who were designated on an NIH research project g...
Source: NIH Extramural Nexus - March 6, 2024 Category: Research Authors: Mike Lauer Tags: blog Open Mike cumulative investigator rate Funding data funding rate Source Type: funding
Institutional Translational Research Training Program (T32 - Clinical Trial Not Allowed)
Funding Opportunity PAR-24-108 from the NIH Guide for Grants and Contracts. The purpose of the NINDS Institutional Translational Research Training Program is to equip trainees with the knowledge and skills needed to advance basic research toward clinical application. These programs will support, students and/or postdocs conducting basic, disease-relevant research in an environment that includes 1) basic neuroscientists and clinicians who are actively engaged in collaborative research projects, 2) neuroscience researchers with expertise in translational processes who are conducting research designed to move basic discove...
Source: NIH Funding Opportunities (Notices, PA, RFA) - February 28, 2024 Category: Research Source Type: funding
Mathematical Sciences Research Institutes
Full Proposal Deadline Date: March 14, 2024 Program Guidelines: NSF 23-606Mathematical Sciences Research Institutes are national resources that aim to advance research in the mathematical sciences through programs supporting discovery and dissemination of knowledge in mathematics and statistics and enhancing connections to related fields in which the mathematical sciences can play important roles. Institute activities help focus the attention of some of the best mathematical minds on problems of particular importance and timeliness. Institutes are also community ...More at https://beta.nsf.gov/programid/5302This is an NSF ...
Source: NSF Upcoming Due Dates - February 13, 2024 Category: Science Source Type: funding
Modular R01s in Cancer Control and Population Sciences (R01 Clinical Trial Optional)
Funding Opportunity PAR-24-122 from the NIH Guide for Grants and Contracts. This Notice of Funding Opportunity (NOFO) encourages applications for research in cancer control and population sciences. The overarching goal is to provide support to promote research efforts on novel scientific ideas that have the potential to substantially advance cancer research in statistical and analytic methods, epidemiology, cancer survivorship, cancer-related behaviors and behavioral interventions, healthcare delivery, and digital health and data science, and implementation science. (Source: NIH Funding Opportunities (Notices, PA, RFA))
Source: NIH Funding Opportunities (Notices, PA, RFA) - January 18, 2024 Category: Research Source Type: funding
NIH StrokeNet Clinical Trials and Biomarker Studies for Stroke Treatment, Recovery, and Prevention (UG3/UH3 Clinical Trial Optional)
Funding Opportunity PAR-24-101 from the NIH Guide for Grants and Contracts. This NOFO encourages applications for multi-site exploratory and confirmatory clinical trials focused on promising interventions; biomarker or outcome measure validation studies that are immediately preparatory to trials in stroke prevention, treatment, and recovery; and ancillary studies designed to add scientific aims to active studies being conducted within StrokeNet. Successful applicants will collaborate and conduct the study within the NIH StrokeNet. Following peer review, NINDS will prioritize studies among the highest scoring to be cond...
Source: NIH Funding Opportunities (Notices, PA, RFA) - December 28, 2023 Category: Research Source Type: funding
Notice of Information: NIMH List of Human Genes Having Rare Variants with Strong Statistical Support for Association to Mental Health Traits
Notice NOT-MH-24-370 from the NIH Guide for Grants and Contracts (Source: NIH Funding Opportunities (Notices, PA, RFA))
Source: NIH Funding Opportunities (Notices, PA, RFA) - November 29, 2023 Category: Research Source Type: funding
Assay Validation of High Quality Markers for Clinical Studies in Cancer (UH3 Clinical Trials Not Allowed)
Funding Opportunity PAR-23-314 from the NIH Guide for Grants and Contracts. Through this Notice of Funding Opportunity (NOFO), the National Cancer Institute (NCI) intends to accelerate the adoption and validation of molecular/cellular/imaging markers (referred to as "markers" or "biomarkers") and assays for cancer detection, diagnosis, prognosis, monitoring, and prediction of response or resistance to treatment, as well as markers for cancer prevention and control. This NOFO will also support the validation of pharmacodynamic markers and markers of toxicity. Applicants to this NOFO must have an assay(s) whose performanc...
Source: NIH Funding Opportunities (Notices, PA, RFA) - November 1, 2023 Category: Research Source Type: funding
Assay Validation of High Quality Markers for Clinical Studies in Cancer (UH2/UH3 Clinical Trial Not Allowed)
Funding Opportunity PAR-23-313 from the NIH Guide for Grants and Contracts. Through this Notice of Funding Opportunity (NOFO), the National Cancer Institute (NCI) invites applications to support the validation of molecular/cellular/imaging markers (referred to as "markers" or "biomarkers") and assays for cancer detection, diagnosis, prognosis, monitoring, and prediction of response or resistance to treatment, as well as markers for cancer prevention and control. This FOA will support investigator-initiated research for both analytical, and clinical validation of assays to be used in cancer treatment, control, or prevent...
Source: NIH Funding Opportunities (Notices, PA, RFA) - November 1, 2023 Category: Research Source Type: funding
Webinar Available to Help Improve Animal Experimental Design
The NIH office of Laboratory Animal Welfare (OLAW) released a webinar recording on how the NC3Rs Experimental Design Assistant (EDA) can assist researchers plan for their studies involving animals. This resource builds on our related efforts to strengthen the rigor, reproducibility, and translatability of NIH-supported animal research (see this NIH Open Mike blog for more).
This free online tool helps users build a diagram representing an experimental plan, provides customized feedback, and can make suggestions on statistical methods, randomization, blinding, sample sizes, and other critical design aspects. Dr. Esther P...
Source: NIH Extramural Nexus - October 11, 2023 Category: Research Authors: NIH Staff Tags: New Resources Animal Welfare rigor Source Type: funding
Revision Applications for Validation of Biomarker Assays Developed Through NIH-Supported Research Grants (R01 Clinical Trial Not Allowed)
Funding Opportunity PAR-24-047 from the NIH Guide for Grants and Contracts. Through this Notice of Funding Opportunity (NOFO) is to accelerate the pace of translation of NCI-supported methods/assays/technologies (referred to as "assays") to the clinic. Specifically, the focus of this NOFO is on the adaption and clinical validation of molecular/cellular/imaging markers (referred to as "markers" r "biomarkers") for cancer detection, diagnosis, prognosis, monitoring, and prediction of response in treatment, as well as markers for cancer control and prevention. Research applications may support the acquisition of well-annot...
Source: NIH Funding Opportunities (Notices, PA, RFA) - October 10, 2023 Category: Research Source Type: funding
Limited Competition: The Harmonized Cognitive Assessment Protocol (HCAP) Network (U24 Clinical Trial Not Allowed)
Funding Opportunity RFA-AG-24-035 from the NIH Guide for Grants and Contracts. This Notice of Funding Opportunity (NOFO) invites applications to continue critical ongoing network and infrastructure support for advancing development in a specific high-priority area of behavioral and social research on Alzheimers disease (AD) and AD-related dementias (ADRD): The Harmonized Cognitive Assessment Protocol (HCAP) International AD/ADRD Research Network. Network/infrastructure-building activities include but are not limited to meetings to develop novel research areas and interact on the development of infrastructure; small-scal...
Source: NIH Funding Opportunities (Notices, PA, RFA) - September 6, 2023 Category: Research Source Type: funding
Addressing Rigor in Scientific Studies
Guest blog by Devon C. Crawford, Ph.D., Program Director, Office of Research Quality, NIH’s National Institute of Neurological Disorders and Stroke. Originally published on the NIH Science, Health, and Public Trust blog.
Devon C. Crawford, Ph.D., Program Director, Office of Research Quality
Science communication is rapidly evolving. The growing use of preprints and the sheer number of published studies make it increasingly difficult to determine which findings are worthy of attention. Not all scientific studies are created equal. Communicators need to discern which are reputable in order to know what to co...
Source: NIH Extramural Nexus - August 14, 2023 Category: Research Authors: NIH Staff Tags: blog Open Mike Grants policy rigor Source Type: funding
