Application of one –factor- at-a-time and statistical designs to enhance α-amylase production by a newly isolate Bacillus subtilis strain-MK1
Publication date: Available online 20 October 2019Source: Biocatalysis and Agricultural BiotechnologyAuthor(s): Samia A. Ahmed, MohamedA.A. Abdella, Gamal M. El-Sherbiny, Atef M. Ibrahim, Aliaa R. El-Shamy, SherienM.M. AtallaAbstractα-amylase is a starch hydrolyzing enzyme which has many industrial applications. In the present study, α-amylase producers were isolated from farm soil in Egypt (Sadat City). Screening was done by iodine test, based on the clear zone around the sample in starch agar plates. The most potent isolate MK1 was identified (morphologically and biochemically) and confirmed by 16S rRNA gene ...
Source: Biocatalysis and Agricultural Biotechnology - October 22, 2019 Category: Biotechnology Source Type: research

Stability Indicating RP-HPLC Method for Simultaneous Determination of Omeprazole and Aspirin in the Presence of Salicylic Acid as Degradation Product
Publication date: Available online 20 October 2019Source: Microchemical JournalAuthor(s): Amira H. Kamal, Aya A. Marie, Sherin F. HammadAbstractReversed-phase high performance liquid chromatographic method (RP-HPLC) was applied for simultaneous determination of aspirin (ASP) and omeprazole (OMP) in presence of salicylic acid (SA) as the most common degradation product of ASP. The drugs were exposed to different stress conditions including acid, alkali, neutral hydrolysis, oxidation, and photodegradation. The separation was carried out on the Thermo Scientific Hypersil ODS column (250 × 4.6 mm, 5µm) column. ...
Source: Microchemical Journal - October 22, 2019 Category: Chemistry Source Type: research

Integrated Chemometric Approach to Optimize Sample Preparation for Detecting Metabolic Changes Provoked by Abiotic Stress in Coffea arabica L. Leaf Fingerprints
The effects of water-deficit stress on irrigated and unirrigated field plants of Coffea arabica L. genotype IAPAR 59 were investigated. Plant extracts were obtained following an ethanol-dichloromethane-hexane statistical mixture design. Proton nuclear magnetic resonance (1H NMR) fingerprints of the extracts were discriminated using factor analysis (FA) and hierarchical clustering techniques. Extracts from the 1:1:1 ternary mixture presented the largest discriminations compared with those from the pure solvents or their 1:1 binary mixtures. Metabolites resulting from fermentation processes and nutritional deficiencies as we...
Source: Journal of the Brazilian Chemical Society - October 22, 2019 Category: Chemistry Source Type: research

Factors associated with inadequate follow-up of children with congenital syphilis
CONCLUSIONS Most children with congenital syphilis attended primary care for follow-up, but the services do not meet the recommendations of the Brazilian Ministry of Health for adequate follow-up.RESUMO OBJETIVO Analisar fatores associados ao seguimento ambulatorial n ão adequado de crianças notificadas com sífilis congênita. MÉTODOS Estudo de coorte não concorrente, realizado em unidades de atenção primária e três maternidades de referência de Fortaleza (Ceará). Os dados foram coletados de setembro de 2013 a setembro de 2016 nas fichas de not...
Source: Revista de Saude Publica - October 22, 2019 Category: International Medicine & Public Health Source Type: research

Yellow fever: profile of cases and factors associated with death in a hospital in the State of Rio de Janeiro, 2017–2018
CONCLUSIONS This study contributed to the knowledge on the profile of confirmed cases of high severity yellow fever. The main factors associated with death were changes in renal excretion and elevated serum transaminases, especially ALT. High lethality emphasizes the need for early diagnosis and treatment, and the importance of increasing vaccination coverage.RESUMO OBJETIVO Descrever o perfil cl ínico-epidemiológico dos casos confirmados de febre amarela internados em hospital geral de referência para doenças infecciosas no estado do Rio de Janeiro, Brasil, de 11 de março de 2017 a 15 de ...
Source: Revista de Saude Publica - October 22, 2019 Category: International Medicine & Public Health Source Type: research

The association of fatigue with dispositional mindfulness: relationships by levels of depressive symptoms, sleep quality, childhood adversity, and chronic medical conditions
Publication date: Available online 20 October 2019Source: Preventive MedicineAuthor(s): Robert C. Whitaker, Allison N. Herman, Tracy Dearth-Wesley, Kenneth Hubbell, Ryan Huff, Liam J. Heneghan, Peter C. RoweAbstractAlthough mindfulness-based interventions may be effective in addressing the common symptom of fatigue, no population-based studies have examined the relationship between mindfulness and fatigue. We determined whether higher levels of dispositional mindfulness were associated with lower levels of fatigue. Cross-sectional data were obtained through the Pennsylvania Head Start Staff Wellness Survey, a 2012 web-base...
Source: Preventive Medicine - October 22, 2019 Category: International Medicine & Public Health Source Type: research

Early Effects of the Trauma Collaborative Care Intervention: Results From a Prospective Multicenter Cluster Clinical Trial
Conclusions: Results suggest TCC may have a small positive effect on early outcomes, but use of the services was highly variable among sites. Level of Evidence: Therapeutic Level I. See Instructions for Authors for a complete description of levels of evidence. (Source: Journal of Orthopaedic Trauma)
Source: Journal of Orthopaedic Trauma - October 21, 2019 Category: Orthopaedics Tags: Original Article Source Type: research

Effect of Nail Size, Insertion, and Δ Canal-Nail on the Development of a Nonunion After Intramedullary Nailing of Femoral Shaft Fractures
Conclusion: Similar healing rates occurred regardless of IMN diameter, Δ canal-nail diameter after reaming, or insertion site. This indicates that a closed section, cannulated, interlocked, titanium alloy IMN with a diameter of 10 mm can be considered the standard diameter for the treatment of acute femoral shaft fractures, regardless of entry point. This should be associated with less reaming and therefore shorter operative times, and possibly less hospital implant inventories as well. Larger diameter IMN should be reserved for revision surgery. Level of Evidence: Therapeutic Level III. See Instructions for Aut...
Source: Journal of Orthopaedic Trauma - October 21, 2019 Category: Orthopaedics Tags: Original Article Source Type: research

Direct cost of Parkinson's disease in a health system with high judicialization: evidence from Colombia.
Conclusions: In the context of high judicialization, patients suffering from PD must increasingly use the judicial system to access treatment. To promote more equitable and efficient access benefit packages, developing countries must consider more thoroughly the needs of these patients. PMID: 31627711 [PubMed - as supplied by publisher] (Source: Expert Review of Pharmacoeconomics and Outcomes Research)
Source: Expert Review of Pharmacoeconomics and Outcomes Research - October 21, 2019 Category: Health Management Tags: Expert Rev Pharmacoecon Outcomes Res Source Type: research

Exploratory study of dorsal visual stream dysfunction in autism; A case series
ConclusionsWe conclude that mechanisms driving OA (which is defined as ‘impaired visually guided movement’) may underpin severe motor impairment, in autism. CVIS and VMIS may be useful indicators of severity of spatial cognitive impairment. (Source: Research in Autism Spectrum Disorders)
Source: Research in Autism Spectrum Disorders - October 21, 2019 Category: Psychiatry Source Type: research

The natural history of seizures and neuropsychiatric symptoms in childhood epilepsy with centrotemporal spikes (CECTS)
We report the psychiatric, behavioral, and cognitive profiles over the course of disease from a large, prospectively-enrolled, longitudinal cohort of children with CECTS. We further characterize the detailed seizure course and test the relationship between several proposed risk factors and neuropsychiatric and seizure outcomes in these children.MethodsPatients diagnosed with CECTS were enrolled as part of a community-based study and followed from diagnosis through disease resolution (16.0 ± 3.1 years, N = 60). Twenty sibling controls were also recruited. We report the natural history of premorbid neuropsyc...
Source: Epilepsy and Behavior - October 21, 2019 Category: Neurology Source Type: research

Patterns of default mode network in temporal lobe epilepsy with and without hippocampal sclerosis
This article is part of the Special Issue “NEWroscience 2018” (Source: Epilepsy and Behavior)
Source: Epilepsy and Behavior - October 21, 2019 Category: Neurology Source Type: research

Motivations and Challenges Towards Research Activities Among Undergraduate Dental Hygiene Students.
Authors: Partido BB, Colón M Abstract Purpose: Research is integral to dental hygiene practice, graduate education, and the advancement of the dental hygiene profession. The purpose of this study was to identify the motivations and challenges toward participation in research activities as perceived by undergraduate dental hygiene students.Methods: A nonprobability sample of undergraduate dental hygiene students from across the United States was used for this cross-sectional, electronic survey. Inclusion criteria were students entering their final year of their dental hygiene education program. Descriptive an...
Source: Journal of Dental Hygiene - October 21, 2019 Category: Dentistry Tags: J Dent Hyg Source Type: research

Practice Patterns and Attitudes of Expanded Function Dental Auxiliaries in the State of Maine.
Conclusions: EFDA practitioners are providing needed oral health care services, however they may not be providing access to care for the intended at-risk and underserved populations in designated geographic areas. Practice patterns of EFDAs in Maine should be assessed in greater depth. PMID: 31628174 [PubMed - in process] (Source: Journal of Dental Hygiene)
Source: Journal of Dental Hygiene - October 21, 2019 Category: Dentistry Tags: J Dent Hyg Source Type: research

Color-Blind Racial Attitudes in Dental Hygiene Students: A pilot study.
Conclusion: A majority of the participants in this pilot study possessed moderate levels of color-blind racial attitudes, suggesting rejection of the concept of racism. Color-blind racial attitudes and biases have been linked to a lack of awareness of White privilege. Further education in this area may foster improved interactions with diverse patient populations. PMID: 31628172 [PubMed - in process] (Source: Journal of Dental Hygiene)
Source: Journal of Dental Hygiene - October 21, 2019 Category: Dentistry Tags: J Dent Hyg Source Type: research

Comparison of perceptions of unmet supportive care needs between cancer patients and their oncologists
AbstractPurposeThe prevalence of cancer in the Middle East is increasing and predicted to nearly double by 2030. In the United Arab Emirates (UAE), cancer ranks as the third leading cause of death. Yet, there are limited data describing the needs of cancer patients in the region. The purpose of this study is to compare cancer patients ’ reports of unmet supportive care needs with the perceptions of their oncologists.MethodsA cross-sectional survey of cancer patients and their oncologists, using an Arabic translation of the short form of the Supportive Care Needs Survey (SCNS-SF34), was conducted at a major oncology c...
Source: Supportive Care in Cancer - October 21, 2019 Category: Cancer & Oncology Source Type: research

Body changes after cancer: female cancer patients ’ perceived social support and their perspective on care
ConclusionsHalf of the female cancer patients reported to receive sufficient social support concerning body changes after cancer. Perceived support depended on age, education, relationship status, and treatment modality. The need for more care was moderate. (Source: Supportive Care in Cancer)
Source: Supportive Care in Cancer - October 21, 2019 Category: Cancer & Oncology Source Type: research

High adherence of patients with multiple myeloma who receive treatment with immunomodulatory drugs (IMIDS) in hematology/oncology group practices in Germany
ConclusionsMyeloma patients seem to be highly adherent  to IMID treatments. (Source: Supportive Care in Cancer)
Source: Supportive Care in Cancer - October 21, 2019 Category: Cancer & Oncology Source Type: research

The efficacy of the ganglion impar block in perineal and pelvic cancer pain
This article aims to evaluate the effectiveness, security, and performance difficulty of GIB in patients with pelvic and perineal oncological pain.MethodsA retrospective study between January 2016 and August 2017. Patients with poorly controlled pelvic oncological pain and patients experimenting opioid side effects in which GIB was performed ambulatory were included. Prognostic GIB was performed, under echographic and fluoroscopic control, with local anesthetic and corticoid. The neurolytic block was performed under fluoroscopic guidance. The technique was performed by the same anesthetist with pain management competence. ...
Source: Supportive Care in Cancer - October 21, 2019 Category: Cancer & Oncology Source Type: research

Isolated adrenal metastectomy has a low morbidity rate irrespective of performing surgical sub-specialty.
Authors: Gurtner KE, May DN, Raman JD, Lata-Arias K, Canter DJ Abstract INTRODUCTION: There has been growing use of adrenalectomy as a potentially curative treatment option for patients with oligometastatic disease to the adrenal gland. We sought to compare the perioperative outcomes of patients undergoing isolated adrenalectomy in the setting of disseminated cancer using the American College of Surgeons National Surgical Quality Improvement Program (ACS-NSQIP) database. Furthermore, we examined the impact of performing surgical sub-specialty on outcomes. MATERIALS AND METHODS: Data from the ACS-NSQIP database ...
Source: Canadian Journal of Urology - October 21, 2019 Category: Urology & Nephrology Tags: Can J Urol Source Type: research

Anatomic GreenLight laser vaporization-incision technique for benign prostatic hyperplasia using the XPS LBO-180W system: How I do it.
The objective of this article is to detail our surgical approach to the anatomic GreenLight laser vaporization-incision technique using the XPS LBO-180W system, based on extensive personal experience with both enucleation and vaporization techniques using various laser technologies. Standardization of the VIT based on proper cystoscopy, knowledge of prostate anatomy with preoperative ultrasound, and routine technique is essential to developing consistent, reproducible and optimal surgical outcomes. PMID: 31629449 [PubMed - in process] (Source: Canadian Journal of Urology)
Source: Canadian Journal of Urology - October 21, 2019 Category: Urology & Nephrology Tags: Can J Urol Source Type: research

Single-dose perioperative mitomycin-C versus thiotepa for low-grade noninvasive bladder cancer.
CONCLUSIONS: As single-dose perioperative agents, both thiotepa and MMC were associated with similar recurrence-free survival rates. PMID: 31629441 [PubMed - in process] (Source: Canadian Journal of Urology)
Source: Canadian Journal of Urology - October 21, 2019 Category: Urology & Nephrology Tags: Can J Urol Source Type: research

Racial disparities in late-stage prostate cancer: a SEER analysis 2005-2015.
Authors: Rodriguez S, Sparks AD, Zhou H, Amdu RL, Lin J Abstract INTRODUCTION: To evaluate the impact of prostate cancer screening guidelines on different racial and ethnic populations. MATERIALS AND METHODS: Data was collected from the 2005-2015 Surveillance, Epidemiology, and End Results (SEER) program. Incidence of prostate cancer diagnosis was categorized and analyzed by stage, race/ethnicity, and age group. Appropriate univariate and multivariable statistical analysis was performed. RESULTS: The odds of being diagnosed with regional-stage prostate cancer in 2013-2015 were 1.3 times higher for black men...
Source: Canadian Journal of Urology - October 21, 2019 Category: Urology & Nephrology Tags: Can J Urol Source Type: research

Statistical Parametric Mapping as a Measure of Differences Between Limbs: Applications to Clinical Populations.
This study demonstrated the ability of SPM to assess interlimb differences in lower-extremity movement during 2 example tasks: running and landing. Three-dimensional motion analysis was used to determine sagittal and frontal plane lower-extremity joint angles in (1) young and older individuals during running and (2) patients with anterior cruciate ligament reconstruction and uninjured control athletes during landing. Interlimb differences within each group were compared using SPM and paired t tests on peak discrete angles. No differences between limbs were found between young and older runners using SPM. Peak ank...
Source: Journal of Applied Biomechanics - October 21, 2019 Category: Sports Medicine Tags: J Appl Biomech Source Type: research

The Relationship Between Personality Traits and Muscle Injuries in Swedish Elite Male Football Players.
CONCLUSION: A player's stress susceptibility should be taken into consideration by the player, coaches, and medical staff when assessing the risk of a muscle injury. Also, preventive measures available for these players may need to be considered. PMID: 31629329 [PubMed - as supplied by publisher] (Source: Journal of Sport Rehabilitation)
Source: Journal of Sport Rehabilitation - October 21, 2019 Category: Sports Medicine Tags: J Sport Rehabil Source Type: research

Underutilization of Cardiac Therapies in Patients with Acute Ischemic Stroke and Elevated Troponin.
This study aims to determine this rate of utilization. MATERIALS/METHODS: A single-center review of 83 patients with AIS and measured troponin was conducted. Patients were stratified based on elevated and non-elevated troponin. Between groups, we measured the utilization of evidence-based cardiac therapies and used a univariate logistic regression to compare outcomes of mortality, re-hospitalization, recurrent acute ischemic stroke, recurrent acute myocardial infarction, and a composite of these outcomes. RESULTS: Of 83 patients, 25 had elevated troponin and 58 had non-elevated troponin. There was no statistical di...
Source: Cardiovascular and Hematological Agents in Medicinal Chemistry - October 21, 2019 Category: Cardiology Tags: Cardiovasc Hematol Agents Med Chem Source Type: research

Youth Access to Naloxone: The Next Frontier?
Recent statistics from the Centers for Disease Control point to a potential slowing of the number of opioid overdose deaths in the U.S. for the first time since 1990 [1]. Although this suggests that we may at last be seeing positive impacts of some of the public health measures deployed across the country, several important gaps remain to be filled. For instance, although the number of prescriptions for naloxone —currently the only proven and readily accessible overdose reversal medication [2]—has increased tremendously, it remains 69 times lower than the number of high-potency opioid prescriptions filled [3]. ...
Source: Journal of Adolescent Health - October 21, 2019 Category: Child Development Authors: Nicholas Chadi, Scott E. Hadland Tags: Editorial Source Type: research

Effects of ohmic heating on technological properties of whole egg
In conclusion, this study demonstrated that ohmic heating is a suitable alternative to conventional pasteurization. Low temperature treatments are preferable to avoid possible rheological issues due to protein denaturation.Industrial relevanceWhole egg is a protein ingredient with multiple technological properties, used in many foods. Due to safety reasons, food manufacturers often use pasteurized liquid egg products, microbiologically safer and easier to handle with respect to shell eggs. In order to satisfy the required sanitary levels for liquid egg products, thermal pasteurization treatments are needed. However, since ...
Source: Innovative Food Science and Emerging Technologies - October 21, 2019 Category: Food Science Source Type: research

Analysis of hypothermia through the acute phase in major burns patients: Nursing care.
CONCLUSIONS: Due to the presence of hypothermia on admission, and to the fact that the average temperature does not exceed 36°C until at least 16hours after the burn, nurses must know and promptly administer adequate reheating measures to improve chances of survival in major burns. PMID: 31629638 [PubMed - as supplied by publisher] (Source: Enfermeria Intensiva)
Source: Enfermeria Intensiva - October 21, 2019 Category: Nursing Tags: Enferm Intensiva Source Type: research

[ASAP] Delayed Photoluminescence and Modified Blinking Statistics in Alumina-Encapsulated Zero-Dimensional Inorganic Perovskite Nanocrystals
The Journal of Physical Chemistry LettersDOI: 10.1021/acs.jpclett.9b02594 (Source: The Journal of Physical Chemistry Letters)
Source: The Journal of Physical Chemistry Letters - October 21, 2019 Category: Chemistry Authors: Tianle Guo †, Riya Bose†, Xiaohe Zhou†, Yuri N. Gartstein†, Haoze Yang§, Sunah Kwon‡, Moon J. Kim‡, Marat Lutfullin?, Lutfan Sinatra?, Issam Gereige?, Ahmed Al-Saggaf?, Osman M. Bakr§, Omar F. Mohammed§, and Anton V. Malko*† Source Type: research

Influence of the cotton and silastic seton on the distance of the anal sphincter cables after fistulotomy in rats
Publication date: Available online 19 October 2019Source: Journal of ColoproctologyAuthor(s): Ana Laura Sanches Lima, Beatriz Schorro Gianini, Bruna Miranda Santana, Carlos Henrique Marques dos Santos, Doroty Mesquita Dourado, Juliano Seger Falcão, Lucas Bannwart, Sara Jéssica Falcão CâmaraAbstractRationaleFistulotomy is a procedure widely used in the treatment of anal fistulas but is associated with varying degrees of fecal incontinence that could be minimized by previous use of sedentum, and the material used may influence the outcome.PurpouseTo compare cotton and silastic used as setons in the...
Source: Journal of Coloproctology - October 21, 2019 Category: Gastroenterology Source Type: research

Correlation of panoramic high-risk markers with the cone beam CT findings in the preoperative assessment of the mandibular third molars
ConclusionCanal deviation and interruption of white lines were associated with loss of canal cortication on CBCT, indicating a direct contact between the roots and the mandibular canal which required a further assessment prior to the extraction. (Source: Journal of Dental Sciences)
Source: Journal of Dental Sciences - October 21, 2019 Category: Dentistry Source Type: research

Maximizing the Outcomes of Breast Cancer Prevention
Cancer mortality in the United States has declined by about 1.5% per year since 1999. Patients with most of the common solid tumors have experienced decreased mortality risk over this period, including those with breast cancer, in whom mortality fell by 1.8% per year between 1998 and 2016. Although there is much to celebrate in these statistics, there is still a long way to go. Breast cancer remains the second leading cause of cancer death among US women, with an estimated 42  000 deaths in 2018. At this rate, it would take 80 years for breast cancer mortality to fall to less than 10 000 women per year. (Source: JAMA Internal Medicine)
Source: JAMA Internal Medicine - October 21, 2019 Category: Internal Medicine Source Type: research

Sensors, Vol. 19, Pages 4576: A SINS/DVL Integrated Positioning System through Filtering Gain Compensation Adaptive Filtering
Cong Hu Because of the complex task environment, long working distance, and random drift of the gyro, the positioning error gradually diverges with time in the design of a strapdown inertial navigation system (SINS)/Doppler velocity log (DVL) integrated positioning system. The use of velocity information in the DVL system cannot completely suppress the divergence of the SINS navigation error, which will result in low positioning accuracy and instability. To address this problem, this paper proposes a SINS/DVL integrated positioning system based on a filtering gain compensation adaptive filtering technology that consi...
Source: Sensors - October 21, 2019 Category: Biotechnology Authors: Xiaozhen Yan Yipeng Yang Qinghua Luo Yunsai Chen Cong Hu Tags: Article Source Type: research

The folded X-pattern is not necessarily a statistical signature of decision confidence
by Manuel Rausch, Michael Zehetleitner Recent studies have traced the neural correlates of confidence in perceptual choices using statistical signatures of confidence. The most widely used statistical signature is the folded X-pattern, which was derived from a standard model of confidence assuming an objective definition of confidence as the posterior probability of making the correct choice given the evidence. The folded X-pattern entails that confidence as the subjective probability of being correct equals the probability of 0.75 if the stimulus in neutral about the choice options, increases with discriminability of the...
Source: PLoS Computational Biology - October 21, 2019 Category: Biology Authors: Manuel Rausch Source Type: research

A multi-scale coevolutionary approach to predict interactions between protein domains
by Giancarlo Croce, Thomas Gueudr é, Maria Virginia Ruiz Cuevas, Victoria Keidel, Matteo Figliuzzi, Hendrik Szurmant, Martin Weigt Interacting proteins and protein domains coevolve on multiple scales, from their correlated presence across species, to correlations in amino-acid usage. Genomic databases provide rapidly growing data for variability in genomic protein content and in protein sequences, calling for computational pr edictions of unknown interactions. We first introduce the concept ofdirect phyletic couplings, based on global statistical models of phylogenetic profiles. They strongly increase the accuracy ...
Source: PLoS Computational Biology - October 21, 2019 Category: Biology Authors: Giancarlo Croce Source Type: research

Molecules, Vol. 24, Pages 3790: Levels of the Thiocyanate in the Saliva of Tobacco Smokers in Comparison to e-Cigarette Smokers and Nonsmokers Measured by HPLC on a Phosphatidylcholine Column
lewska The aim of the study was to estimate the thiocyanate levels in saliva of cigarette smokers in comparison to e-cigarette smokers and nonsmokers. To improve our understanding of the influence of smoking on the oral level of thiocyanate, we conducted an assessment of human saliva, in 24 individuals (eight tobacco smokers, eight e-cigarette smokers, and eight nonsmokers). High-Performance Liquid Chromatography with ultraviolet detection (HPLC-UV) using a unique phosphatidylcholine column was applied in this assay. Thiocyanate ion was detected directly by its absorbance at 210 nm. The method presents a new applicatio...
Source: Molecules - October 21, 2019 Category: Chemistry Authors: Flieger Kawka Tatarczak-Michalewska Tags: Article Source Type: research

IJERPH, Vol. 16, Pages 4032: Analysis of the Association between Running Performance and Game Performance Indicators in Professional Soccer Players
This study aimed to identify associations between RP and GPI in professional soccer players and to compare RP and GPI among soccer playing positions. One hundred one match performances were observed over the course of half of a season at the highest level of national competition in Croatia. Players (mean ± SD, age: 23.85 ± 2.88 years; body height: 183.05 ± 8.88 cm; body mass: 78.69 ± 7.17 kg) were classified into five playing positions (central defenders (n = 26), full-backs (n = 24), central midfielders (n = 33), wide midfielders (n = 10), and forwards (n = 8). R...
Source: International Journal of Environmental Research and Public Health - October 21, 2019 Category: Environmental Health Authors: Modric Versic Sekulic Liposek Tags: Article Source Type: research

An Observational Study of Retail Pharmacy Naloxone Prescriptions: Differences Across Provider Specialties and Patient Populations
ConclusionsOur findings reflect a need to better understand barriers to uptake of naloxone prescribing behavior among physicians and other prescribers to ensure individuals have adequate opportunity to receive naloxone from their treating clinicians. (Source: Journal of General Internal Medicine)
Source: Journal of General Internal Medicine - October 21, 2019 Category: Internal Medicine Source Type: research

Reply to Letter to Editor: Hydroxychloroquine Blood Levels Predict Hydroxychloroquine Retinopathy
AbstractThese observed relationship between HCQ blood levels and risk of toxicity in these results is very similar to what we presented in the published paper.Second, we used logistic regression to determine whether there was still a statistically significant association between mean HCQ blood levels and retinopathy after adjusting for duration of time on HCQ. The results were similar to those seen in the paper and above (P ‐value=0.016, p‐value for trend=0.003 after adjustment). (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - October 21, 2019 Category: Rheumatology Authors: Michelle Petri, Jessica Li, Laurence S. Magder, Daniel W. Goldman Tags: REPLY TO LETTER TO THE EDITOR Source Type: research

Contemporary less invasive spinal instrumentation for AO C-type posterior pelvic ring injuries
This study evaluates efficacy and safety of contemporary spinal instrumentation for AO/type C posterior pelvic ring (PPR) injuries.MethodsTwenty-two consecutive patients, aged 36  ± 17 years, were managed with spinal instrumentation with spinopelvic fixation (SPF) or non-spinopelvic fixation (NSPF) and less invasive surgery. There were 16 vertically unstable sacral fractures and six iliosacral dislocations. Matta score was used for fragment diastasis and Majeed’s sco re for functional outcome evaluation.ResultsAll patients were followed for 61  ± 8 months postoperat...
Source: European Spine Journal - October 21, 2019 Category: Orthopaedics Source Type: research

Cone beam computed tomographic assessment of mandibular condyle in Kennedy class I patients
ConclusionLoss of posterior teeth is accompanied by significant decrease in condyle height and increase in condyle width with no change in the total condyle volume or antero-posterior dimensions. (Source: Oral Radiology)
Source: Oral Radiology - October 21, 2019 Category: Radiology Source Type: research

Benchmarking of survival outcomes following haematopoietic stem cell transplantation: A review of existing processes and the introduction of an international system from the European Society for Blood and Marrow Transplantation (EBMT) and the Joint Accreditation Committee of ISCT and EBMT (JACIE)
Bone Marrow Transplantation, Published online: 21 October 2019; doi:10.1038/s41409-019-0718-7In many healthcare settings, benchmarking for complex procedures has become a mandatory requirement by competent authorities, regulators, payers and patients to assure clinical performance, cost-effectiveness and safe care of patients. In several countries inside and outside Europe, benchmarking systems have been established for haematopoietic stem cell transplantation (HSCT), but access is not universal. As benchmarking is now integrated into the FACT-JACIE standards, the EBMT and JACIE established a Clinical Outcomes Group (COG) ...
Source: Bone Marrow Transplantation - October 21, 2019 Category: Hematology Authors: John A. Snowden Riccardo Saccardi Kim Orchard Per Ljungman Rafael F. Duarte Myriam Labopin Eoin McGrath Nigel Brook Carmen Ruiz de Elvira Debra Gordon H élène A. Poirel Francis Ayuk Yves Beguin Francesca Bonifazi Alois Gratwohl Noel Milpied John Moore J Source Type: research

Cabozantinib exposure –response analyses of efficacy and safety in patients with advanced hepatocellular carcinoma
AbstractCabozantinib, a multi-kinase inhibitor, is approved in the United States and European Union for treatment of patients with hepatocellular carcinoma following prior sorafenib treatment. In the Phase III CELESTIAL trial, hepatocellular carcinoma patients receiving cabozantinib showed longer overall survival (OS) and progression-free survival (PFS) than those receiving placebo. The approved cabozantinib (Cabometyx®) dose is 60  mg once daily with allowable dose modifications to manage adverse events (AE). Time-to-event Cox proportional hazard exposure–response (ER) models were developed to characterize ...
Source: Journal of Pharmacokinetics and Pharmacodynamics - October 21, 2019 Category: Drugs & Pharmacology Source Type: research

Cancers, Vol. 11, Pages 1603: A Novel Predictor Tool of Biochemical Recurrence after Radical Prostatectomy Based on a Five-MicroRNA Tissue Signature
dler Klaus Jung Within five to ten years after radical prostatectomy (RP), approximately 15–34% of prostate cancer (PCa) patients experience biochemical recurrence (BCR), which is defined as recurrence of serum levels of prostate-specific antigen >0.2 µg/L, indicating probable cancer recurrence. Models using clinicopathological variables for predicting this risk for patients lack accuracy. There is hope that new molecular biomarkers, like microRNAs (miRNAs), could be potential candidates to improve risk prediction. Therefore, we evaluated the BCR prognostic capability of 20 miRN...
Source: Cancers - October 21, 2019 Category: Cancer & Oncology Authors: Zhongwei Zhao Sabine Weickmann Monika Jung Michael Lein Ergin Kilic Carsten Stephan Andreas Erbersdobler Annika Fendler Klaus Jung Tags: Article Source Type: research

The association between clinically determined periodontal disease and prostate-specific antigen concentration in men without prostate cancer: the 2009 –2010 National Health and Nutrition Examination Survey
ConclusionsIn this US nationally representative sample, men with periodontal disease did not have higher serum PSA and were not more likely to have clinically elevated PSA after taking into account age and other factors, contrary to the hypothesis. This study suggests that periodontal disease does not notably affect the specificity of PSA for prostate cancer screening. (Source: Cancer Causes and Control)
Source: Cancer Causes and Control - October 21, 2019 Category: Cancer & Oncology Source Type: research

Cancers, Vol. 11, Pages 1606: A Toolbox for Functional Analysis and the Systematic Identification of Diagnostic and Prognostic Gene Expression Signatures Combining Meta-Analysis and Machine Learning
We present a step-by-step computational protocol for functional gene expression analysis and the identification of diagnostic and prognostic signatures by combining meta-analysis with machine learning and survival analysis. The novelty of the toolbox lies in its all-in-one functionality, generic design, and modularity. It is exemplified for lung cancer, including a comprehensive evaluation using different validation strategies. However, the protocol is not restricted to specific disease types and can therefore be used by a broad community. The accompanying R package vignette runs in ~1 h and describes the workflow in detai...
Source: Cancers - October 21, 2019 Category: Cancer & Oncology Authors: Veronesi Kunz Tags: Article Source Type: research

Experimental study on “ischemic memory” of myocardium with different ischemic degrees by 18 F-FDG PET/CT
AbstractObjectiveGlucose metabolism and ranges of ischemic cardiomyocytes in model rats under fasting or feeding were compared by18F-FDG PET/CT, respectively, to investigate the changes of glucose metabolism after myocardial reperfusion, and to determine time window of myocardial “ischemic memory” under feeding.MethodsThe ischemic –reperfusion model rats were established by ligating the left anterior descending coronary artery of rats. In fasting–feeding experiment, long-ischemia rats (n = 10) under fasting or feeding were subjected to18F-FDG PET/CT at 24  h after modeling. Ischem...
Source: Annals of Nuclear Medicine - October 21, 2019 Category: Nuclear Medicine Source Type: research

Effect of Routine Sport Participation on Short-Term Clinical Neurological Outcomes: A Comparison of Non-Contact, Contact, and Collision Sport Athletes
ConclusionOur findings do not necessarily support the notion that participation in sports associated with exposure to repetitive head impacts has clinically meaningful cumulative effects over the course of a season, nor over four consecutive seasons in high school and collegiate athletes. (Source: Sports Medicine)
Source: Sports Medicine - October 21, 2019 Category: Sports Medicine Source Type: research

Assessing disease severity in bio-na ïve patients with RA on treatment with csDMARDs: insights from the Corrona Registry
ConclusionsThe substantial number of patients with persistent moderate-to-high disease on csDMARDs over a 6-month period and who did not advance treatment indicates that there is considerable need for a treat-to-target approach to care for patients with RA.Key Points•For patients with RA and an inadequate response to treatment with initial csDMARD monotherapy, guidelines recommend treatment advancement; however, this may not be occurring in real-world clinical settings.•In the current study, a substantial proportion of patients (54%) on csDMARDs had persistent moderate-to-severe disease activity at the 6-month ( ...
Source: Clinical Rheumatology - October 21, 2019 Category: Rheumatology Source Type: research