Primary amyloidosis of the breast excised using an oncoplastic reduction approach.
We present a case of surgical removal of primary amyloidosis of the breast utilizing an oncoplastic reduction pattern technique. Primary amyloidosis of the breast is a very rare benign disease characterized by accumulation of insoluble amyloid protein. Biopsy is required for definitive diagnosis, and surgical removal of the mass with clear margins is the main treatment for primary amyloidosis. Oncoplastic reduction pattern technique allows for removal of large breast lesions and correction of the resulting defect by combining the extirpative principles of surgical oncology with the aesthetic principles of breast reduction ...
Source: Breast Disease - April 21, 2020 Category: Cancer & Oncology Tags: Breast Dis Source Type: research

An audit of over 1000 breast cancer patients from a tertiary care center of Northern India.
CONCLUSION: Breast cancer in the Indian scenario is a disease of younger woman who lack the characteristic reproductive and demographic risk factors. This calls for a need to study the clinico-demographic risk factors and characteristics of our own population. PMID: 32310154 [PubMed - as supplied by publisher] (Source: Breast Disease)
Source: Breast Disease - April 21, 2020 Category: Cancer & Oncology Tags: Breast Dis Source Type: research

Evaluation of Tumor infiltrating lymphocytes in breast carcinoma and their correlation with molecular subtypes, tumor grade and stage.
CONCLUSION: The IWTILG recommendations are reproducible and reliable for the evaluation of sTILs and iTILs. TILs, as evaluated on Hematoxylin and eosin (H&E) slides, has been shown in numerous studies now to be a reliable, reproducible, inexpensive and readily available marker of pre-existing antitumor immunity in breast cancer. We suggest that TILs should be evaluated for each case of breast carcinoma and should be part of histopathology report. PMID: 32310155 [PubMed - as supplied by publisher] (Source: Breast Disease)
Source: Breast Disease - April 21, 2020 Category: Cancer & Oncology Tags: Breast Dis Source Type: research

Successful management of diffuse bilateral pseudoangiomatous stromal hyperplasia of the mammary glands by reductive mammoplasty.
Authors: Al-Balas M, Alwiswasy M, Al-Balas H, Serra M, Aleshawi A Abstract Pseudoangiomatous stromal hyperplasia (PASH) is a benign breast condition commonly presented as an incidental microscopic finding. However, it can also manifest as a mass-forming lesion (tumorous PASH) or as gigantomastia (diffuse PASH). Most of the previously reported cases are unilateral tumorous PASH treated by mastectomy. In this article, we reported a rare case of diffuse bilateral PASH. A 21-year-old woman presented with a two-year history of bilateral breast enlargement and neck pain. Physical examination revealed asymmetrical bilater...
Source: Breast Disease - April 14, 2020 Category: Cancer & Oncology Tags: Breast Dis Source Type: research

Breast cancer in elderly Korean women: clinicopathological and biological features.
CONCLUSIONS: Breast cancer had a more aggressive clinicopathological and biological characteristics in elderly Korean women than in Korean women of all ages or elderly women globally. PMID: 32250285 [PubMed - as supplied by publisher] (Source: Breast Disease)
Source: Breast Disease - April 8, 2020 Category: Cancer & Oncology Tags: Breast Dis Source Type: research

YouTube: Searching for answers about breast cancer.
CONCLUSION: While YouTube is an important source of information regarding breast cancer, few videos contain a significant amount of quality information and many of the videos contain false or misleading statements. In an area where patients are often scared and searching for answers, there is a significant need for more high-quality videos to educate patients and dispel myths and pseudoscience. PMID: 32250286 [PubMed - as supplied by publisher] (Source: Breast Disease)
Source: Breast Disease - April 8, 2020 Category: Cancer & Oncology Tags: Breast Dis Source Type: research

Brachial plexus schwannoma mimicking advanced breast carcinoma.
CONCLUSION: The best of our knowledge it is the third description of brachial plexus schwannoma associated with breast cancer and the first with a synchronous association. The knowledge of this pathology and its potential to alter treatment justify the reporting of the present case. PMID: 32083563 [PubMed - as supplied by publisher] (Source: Breast Disease)
Source: Breast Disease - February 23, 2020 Category: Cancer & Oncology Tags: Breast Dis Source Type: research

Selection of the Bacillus thuringiensis Berliner strain to produce a parasporin with cytotoxic activity against MCF-7 breast cancer cells.
CONCLUSION: PSs represent a potential tool to treat this form of breast cancer by providing peptides that may be useful in therapy. PMID: 32065785 [PubMed - in process] (Source: Breast Disease)
Source: Breast Disease - February 18, 2020 Category: Cancer & Oncology Tags: Breast Dis Source Type: research

Intracystic papillary carcinoma of the male breast: Dilemmas in diagnosis and management.
We present a 40 years old male patient with IPC who was managed by modified radical mastectomy and adjuvant hormone therapy. A brief review of the literature and clinical characteristics, pathology, and treatment of IPC are discussed. PMID: 32039836 [PubMed - as supplied by publisher] (Source: Breast Disease)
Source: Breast Disease - February 11, 2020 Category: Cancer & Oncology Tags: Breast Dis Source Type: research

Breast-conserving surgery vs. total mastectomy in patients with triple negative breast cancer in early stages: a propensity score analysis.
CONCLUSION: BCS is a safe alternative to TM in Latin-American patients with early-stage TNBC. PMID: 31903977 [PubMed - as supplied by publisher] (Source: Breast Disease)
Source: Breast Disease - January 8, 2020 Category: Cancer & Oncology Tags: Breast Dis Source Type: research

Role of CD44 in breast cancer.
Authors: Al-Othman N, Alhendi A, Ihbaisha M, Barahmeh M, Alqaraleh M, Al-Momany BZ Abstract Breast cancer (BC) is among the most prevalent type of malignancy affecting females worldwide. BC is classified into different types according to the status of the expression of receptors such as estrogen receptor (ER), human epidermal growth factor receptor 2 (HER2), and progesterone receptor (PR). Androgen receptor (AR) appears to be a promising therapeutic target of breast cancer. Binding of 5α-dihydrotestosterone (DHT) to AR controls the expression of microRNA (miRNA) molecules in BC, consequently, affecting protei...
Source: Breast Disease - December 18, 2019 Category: Cancer & Oncology Tags: Breast Dis Source Type: research

Invasive breast carcinoma with hyaline globules ("thanatosomes").
Invasive breast carcinoma with hyaline globules ("thanatosomes"). Breast Dis. 2019 Dec 10;: Authors: Bezić J Abstract Hyaline globules (thanatosomes) have been observed in many neoplastic and non-neoplastic processes. They represent terminal cytoplasmic structures associated with cytoplasmic blebbing, which are related to cell injury and apoptosis. Thanatosomes are reported rarely in breast tumors. Here we describe a case of invasive breast cancer of no special type with abundant thanatosomes. PMID: 31839600 [PubMed - as supplied by publisher] (Source: Breast Disease)
Source: Breast Disease - December 18, 2019 Category: Cancer & Oncology Tags: Breast Dis Source Type: research

Role of androgen and microRNA in triple-negative breast cancer.
Authors: Al-Othman N, Ahram M, Alqaraleh M Abstract Breast cancer (BC) is the most frequent type of malignancy affecting females worldwide. Molecular-based studies resulted in an identification of at least four subtypes of breast carcinoma, including luminal A and luminal B, Human growth factor receptor (HER-2)-enriched and triple-negative tumors (basal-like and normal breast-like). A proportion of BC cases are of the triple-negative breast cancer (TNBC) type. TNBC lacks the expression of estrogen receptor (ER), progesterone receptor (PR), and HER-2, and is known to express androgen receptor (AR) at considerable le...
Source: Breast Disease - December 18, 2019 Category: Cancer & Oncology Tags: Breast Dis Source Type: research

Evaluation of the expression of P16INK4A by immunohistochemistry in post-neoadjuvant chemotherapy hormone receptor negative breast cancer specimens.
Authors: Febres-Aldana CA, Kuritzky N, Krishnamurthy K, Poppiti R, Howard L Abstract BACKGROUND: Hormone-receptor-negative breast carcinoma (HRNBC), including triple-negative and HER-2 amplified tumors, can overexpress P16INK4a with substantial contribution to tumor progression. In nonneoplastic cells, P16INK4a mediates growth arrest and senescence secondary to cytotoxic compounds. OBJECTIVE: We assessed the impact of neoadjuvant chemotherapy (NAC) on P16INK4a expression in breast specimens. METHODS: P16INK4a and CD-44 were evaluated by immunohistochemistry in biopsies and subsequent post-NAC excision in a ...
Source: Breast Disease - December 18, 2019 Category: Cancer & Oncology Tags: Breast Dis Source Type: research

Infiltration of CD4, CD8, CD56, and Fox-P3-positive lymphocytes in breast carcinoma tissue after neoadjuvant chemotherapy with or without trastuzumab.
Authors: Itoi N, Umeda T, Ishida M, Murata S, Mori T, Kawai Y, Tomida K, Shimizu T, Kushima R, Tani M PMID: 31815683 [PubMed - as supplied by publisher] (Source: Breast Disease)
Source: Breast Disease - December 11, 2019 Category: Cancer & Oncology Tags: Breast Dis Source Type: research

Orbital metastases of invasive lobular breast carcinoma.
Authors: Tsagkaraki IM, Kourouniotis CD, Gomatou GL, Syrigos NK, Kotteas EA Abstract Breast cancer is the main site of origin of orbital metastatic disease. Although invasive lobular breast carcinoma accounts for 10-15% of all breast cancer cases, it has been noticed that it metastasizes to the orbit more often compared to breast cancer of no special type (NST). The pathogenesis of this metastasis is not entirely understood; however, it seems that the unique tissue-specific characteristics of orbital microenvironment might contribute to metastatic disease in this particular site. Given the increasing survival of br...
Source: Breast Disease - October 25, 2019 Category: Cancer & Oncology Tags: Breast Dis Source Type: research

What you see is not always what you get: radiographic-pathologic discordance among benign breast masses.
We present a 33-year-old woman with a large left breast mass that gradually increased in size and provide a review of the current literature regarding the challenge of distinguishing between breast fibroadenomas and hamartomas. PMID: 31561317 [PubMed - as supplied by publisher] (Source: Breast Disease)
Source: Breast Disease - September 30, 2019 Category: Cancer & Oncology Tags: Breast Dis Source Type: research

IAC standardized reporting of breast fine-needle aspiration cytology, Yokohama 2016: A critical appraisal over a 2 year period.
CONCLUSION: FNAC is a simple, reliable, cost effective, first line diagnostic procedure for all breast lumps. In collaboration with physical examination and imaging studies (triple approach), FNAC is a highly sensitive diagnostic tool. Adopting a universally acceptable standardized reporting system for breast cytology can enhance the diagnostic accuracy of FNAC. PMID: 31524134 [PubMed - as supplied by publisher] (Source: Breast Disease)
Source: Breast Disease - September 18, 2019 Category: Cancer & Oncology Tags: Breast Dis Source Type: research

Inflammatory breast cancer: A review from our experience.
CONCLUSION: Despite a more aggressive systemic and loco-regional treatment today, IBC is still a very serious disease with a high mortality. PMID: 31256114 [PubMed - in process] (Source: Breast Disease)
Source: Breast Disease - July 1, 2019 Category: Cancer & Oncology Tags: Breast Dis Source Type: research

Evaluating the incidence of inflammatory breast cancer using in population- and hospital-based cancer registries in Casablanca, Morocco.
CONCLUSIONS: Population-based registries should focus on specific measures for verifying the diagnosis of IBC since physicians may miss documenting the disease in medical records. This study may have implications for better reporting and documentation of IBC in hospital- and population-based cancer registries in Morocco and other similar countries. PMID: 31104003 [PubMed - as supplied by publisher] (Source: Breast Disease)
Source: Breast Disease - May 21, 2019 Category: Cancer & Oncology Tags: Breast Dis Source Type: research

Small breast Schwannoma in an old female; a case report.
We report a case which was presented to and managed in the Oncology center, Mansoura University in November 2017. PMID: 31045508 [PubMed - as supplied by publisher] (Source: Breast Disease)
Source: Breast Disease - May 4, 2019 Category: Cancer & Oncology Tags: Breast Dis Source Type: research

Infiltration of CD4, CD8, CD56, and Fox-P3-positive lymphocytes in breast carcinoma tissue after neoadjuvant chemotherapy with or without trastuzumab.
CONCLUSIONS: The results suggest that Tz therapy induces adaptive cellular immunity, including infiltration of both CD4-positive helper T cells and CD8-positive cytotoxic T cells into the breast carcinoma lesion. PMID: 31006655 [PubMed - as supplied by publisher] (Source: Breast Disease)
Source: Breast Disease - April 24, 2019 Category: Cancer & Oncology Tags: Breast Dis Source Type: research

Upstaging papillary lesions to carcinoma on surgical excision is not impacted by patient race.
CONCLUSIONS: Atypia remains the most significant contributor to the risk of upstaging papillary lesions to malignancy. Our research supports the practice of excising all atypical papillary lesions with selected excision of those without atypia. In our cohort, there was no association between race and risk of upstaging to malignacy. PMID: 30988233 [PubMed - as supplied by publisher] (Source: Breast Disease)
Source: Breast Disease - April 18, 2019 Category: Cancer & Oncology Tags: Breast Dis Source Type: research

Inter-laboratory comparison of Ki-67 proliferating index detected by visual assessment and automated digital image analysis.
CONCLUSION: Proliferation remains one of the most important parameters for tumor characterization helpful in making clinical decisions, but it should be used with great caution. Standardization of the Ki-67 assessment is essential and proliferating index should be expressed as exact numeric value. For patients with proliferative index near the cut-off value, other factors must be considered in making clinical decisions. PMID: 30958325 [PubMed - as supplied by publisher] (Source: Breast Disease)
Source: Breast Disease - April 9, 2019 Category: Cancer & Oncology Tags: Breast Dis Source Type: research

Performance of survivin mRNA as a biomarker for breast cancer among Vietnamese women.
CONCLUSION: Results provide the initial evidence of the expression of survivin mRNA in breast cancer patients in Vietnam, suggesting the role of survivin mRNA in breast cancer molecular pathology. PMID: 30958326 [PubMed - as supplied by publisher] (Source: Breast Disease)
Source: Breast Disease - April 9, 2019 Category: Cancer & Oncology Tags: Breast Dis Source Type: research

Oncology nurses' knowledge about Lymphedema Assessment, Prevention, and  Management among Women with Breast Cancer.
This study was conducted to evaluate the oncology nurses' knowledge about lymphedema assessment, prevention, and management among women with breast cancer, and identify the relationships between oncology nurses' academic qualification, years of experience, and level of knowledge. METHODS: A cross-sectional descriptive design was used. A sample of 150 participants from three institutions completed the study surveys. RESULTS: 60% (N = 90) of the participants did not pass the knowledge test. 70% (N = 105) of the participants showed lack of knowledge regarding BCRL assessment and examination. The results show...
Source: Breast Disease - April 9, 2019 Category: Cancer & Oncology Tags: Breast Dis Source Type: research

A comparative analysis of axillary nodal burden in ultrasound/biopsy positive axilla vs ultrasound negative sentinel lymph node biopsy positive axilla.
Authors: Tandon M, Ball W, Kirby R, Soumian S, Narayanan S Abstract BACKGROUND: Axillary Ultrasound (AUS) is now performed as a protocol in every newly diagnosed breast cancer in most European countries. It is an inexpensive and sensitive tool in hands of a trained operator. All AUS negative patients undergo Sentinel Lymph Node Biopsy (SLNB), while AUS positive patients bypass SLNB and undergo axillary nodal clearance (ANC) as a standard protocol. We wish to analyse these two groups to see if ANC can be foregone in these patients. AIMS AND OBJECTIVES: To compare and analyse the axillary disease burden in early ...
Source: Breast Disease - March 26, 2019 Category: Cancer & Oncology Tags: Breast Dis Source Type: research

A clinicopathological study of fibroadenomas with epithelial proliferation including lobular carcinoma in-situ, atypical ductal hyperplasia, DCIS and invasive carcinoma.
CONCLUSION: In our study population, the most common type of carcinoma arising in fibroadenomas was DCIS, followed by lobular carcinoma in-situ. Lobular carcinoma in-situ was more likely to be confined to the fibroadenoma while most DCIS involved surrounding breast tissue. PMID: 30909180 [PubMed - as supplied by publisher] (Source: Breast Disease)
Source: Breast Disease - March 26, 2019 Category: Cancer & Oncology Tags: Breast Dis Source Type: research

Metastatic breast cancer to the adductor magnus; a case report and literature overview.
We report a case of a patient with a history of stage IIA infiltrating lobular carcinoma of the right breast presenting with a metastatic lesion in the right adductor magnus. She was treated four years prior to the onset of the metastases with a modified radical mastectomy but refused postoperative chemotherapy or adjunctive radiation. PMID: 30856097 [PubMed - as supplied by publisher] (Source: Breast Disease)
Source: Breast Disease - March 13, 2019 Category: Cancer & Oncology Tags: Breast Dis Source Type: research

Breast cancer section analysis correlates with sentinel lymph node biopsies: Precision and topographic anatomy.
CONCLUSIONS: The correlation between the SLN topographic anatomical position and the pathology results, revealed that the majority of the SLN accumulates in the front axillary region. A larger patient population will statistically support this association. PMID: 30829609 [PubMed - as supplied by publisher] (Source: Breast Disease)
Source: Breast Disease - March 6, 2019 Category: Cancer & Oncology Tags: Breast Dis Source Type: research

DSCAM-AS1 up-regulation in invasive ductal carcinoma of breast and assessment of its potential as a diagnostic biomarker.
CONCLUSIONS: The significant up-regulation of DSCAM-AS1 in tumoral tissues compared with ANCTs provides further evidences for participation of this lncRNA in the pathogenesis of breast cancer. PMID: 30594914 [PubMed - as supplied by publisher] (Source: Breast Disease)
Source: Breast Disease - January 1, 2019 Category: Cancer & Oncology Tags: Breast Dis Source Type: research

Expression of urokinase plasminogen activator (uPA) in the leukocytes and tissues of patients with benign and malignant breast lesions.
Authors: Barberi S, Montagna G, Rossi L Abstract OBJECTIVE: to show that the expression of urokinase plasminogen activator (uPA) in the leucocytes of patients with benign and malignant breast lesions correlates with its expression in the lesions, and to explore the role of uPA as a tumour marker in breast cancer. METHODS: using real time reverse transcriptase - polymerase chain reaction (RT-PCR), we examined the expression of uPA in leukocytes and tissues of three groups of women: a) with breast cancer (BC), b) with benign breast lesions and c) a control group of healthy women. An arbitrary value of 1 was assig...
Source: Breast Disease - December 21, 2018 Category: Cancer & Oncology Tags: Breast Dis Source Type: research

Recurrent Mondor's breast disease - hormonal contraceptive involvement.
Authors: Lambat Emery S, Kalovidouri A, David-Montefiore E Abstract Mondor's disease can be a challenging diagnosis. The case we present is of a 29 year-old Brazilian woman, under combined hormonal contraception, who consulted for a painful lump on her right breast. She presented a complete resolution after a local treatment of heparinoid cream and a non-steroidal anti-inflammatory oral treatment, but relapsed 18 months later. Oral combined hormonal contraception was the only "risk factor" found, in this case, and the modification of the latter helped resolve the relapse clinical symptoms. PMID: 30530...
Source: Breast Disease - December 12, 2018 Category: Cancer & Oncology Tags: Breast Dis Source Type: research

Re-excision rate after sector resection for breast cancer: A 5-year retrospective cohort study.
CONCLUSION: BCS using the sector resection technique has a low re-excision rate for positive margins. Younger patients and aggressive tumour biology are important predictive risk factors for positive margins. PMID: 30198861 [PubMed - as supplied by publisher] (Source: Breast Disease)
Source: Breast Disease - September 12, 2018 Category: Cancer & Oncology Tags: Breast Dis Source Type: research

Prospective comparative study assessing role of ultrasound versus thermography in breast cancer detection.
CONCLUSION: We believe that thermography is a non-invasive, safe, and accepted method by patients; however, despite technical advances in it, its diagnostic abilities are still less than those of sonography, so we suggest that it be used as an adjunct in breast cancer diagnosis in selective situations. PMID: 30124439 [PubMed - as supplied by publisher] (Source: Breast Disease)
Source: Breast Disease - August 22, 2018 Category: Cancer & Oncology Tags: Breast Dis Source Type: research

Ductal carcinoma in-situ, cystic hypersecretory type presented by recurrent hemorrhagic cyst.
We reported the first case report of ductal carcinoma in-situ, hypersecretory type, presented by a hemorrhagic cyst. PMID: 30124440 [PubMed - as supplied by publisher] (Source: Breast Disease)
Source: Breast Disease - August 22, 2018 Category: Cancer & Oncology Tags: Breast Dis Source Type: research

Molecular prevalence of human papillomavirus infection among Iranian women with breast cancer.
CONCLUSION: The low frequency of HPV detected in our study does not support an association between breast carcinoma and HPV infection. However, it is possible that HPV may be responsible for breast carcinogenesis only in small percentage of all breast cancer. PMID: 30124441 [PubMed - as supplied by publisher] (Source: Breast Disease)
Source: Breast Disease - August 22, 2018 Category: Cancer & Oncology Tags: Breast Dis Source Type: research

Role of radiotherapy in women over the age of 65 after breast conserving surgery for breast cancer: A 5-year retrospective study.
CONCLUSIONS: XRT in women over the age of 65 did not decrease the risk of LR. Adjuvant XRT in older women should be offered to selective patients with high risk patient and tumour factors. PMID: 30124442 [PubMed - as supplied by publisher] (Source: Breast Disease)
Source: Breast Disease - August 22, 2018 Category: Cancer & Oncology Tags: Breast Dis Source Type: research

Overall survival of elderly patients with breast cancer is not related to breast-cancer specific survival: A single institution experience in Japan.
Authors: Takuwa H, Tsuji W, Yotsumoto F Abstract BACKGROUND: As the aging population grows, the number of elderly breast cancer patients has rapidly increased especially in Japan; a suitable treatment for elderly patients, considering chronic comorbidities and treatment tolerance, is urgently needed. METHODS: In this retrospective study, 286 elderly breast cancer patients were investigated. Tumor characteristics and survival outcome were compared between 70-79-year-old and ≥ 80-year-old groups. Disease-free survival, overall survival, and breast cancer-specific survival were compared, and the effect of varia...
Source: Breast Disease - April 18, 2018 Category: Cancer & Oncology Tags: Breast Dis Source Type: research

Huge mucinous carcinoma of the breast in which doubling time was observed by computed tomography during 3 years without treatment.
Authors: Nakata B, Kuroda K, Yoshida Y, Iimori N, Masuda G, Lee T, Tendo M, Hori T, Sato H, Ishikawa T Abstract Here we report the case of a 77-year-old woman with a huge cancer of the right breast for which size was measured on computed tomography in our hospital preoperatively and in other hospital 3 years earlier. During the 3-year untreated interval, the tumor grew from 4 cm to 13 cm in maximum diameter, and the tumor-volume doubling time (TVDT) was calculated as 209 days. The patient underwent mastectomy with axillary lymph node dissection, with the large skin defect covered by autologous skin graft. The patho...
Source: Breast Disease - March 28, 2018 Category: Cancer & Oncology Tags: Breast Dis Source Type: research

Intracystic breast carcinoma. An important differential diagnosis in postmenopausal patients presenting with a rapidly growing breast cyst. Management and literature review.
Authors: Salemis NS Abstract Intracystic breast carcinoma is a rare clinical entity accounting for 0.5-2% of all breast cancers. It represents a distinctive clinical form rather a histological subtype of breast cancer and can either be in situ or invasive tumor. We herein describe a rare case of intracystic breast carcinoma arising from the wall of a cyst in a postmenopausal patient, who presented with a rapidly growing complex breast cyst. Diagnostic evaluation and management of the patient are discussed along with a review of the literature. Complex breast cysts may represent a diagnostic and therapeutic challeng...
Source: Breast Disease - March 28, 2018 Category: Cancer & Oncology Tags: Breast Dis Source Type: research

The relationship between serum E2 levels and recurrence in premenopausal, ER-positive breast cancer patients: A retrospective study.
CONCLUSION: Among patients who received endocrine therapy without adjuvant chemotherapy, those with longer LHRH-a exposure had favorable prognoses. A potential association was observed between recurrence and E2 concentrations in women with premenopausal ER-positive early-stage breast cancer. PMID: 29578459 [PubMed - as supplied by publisher] (Source: Breast Disease)
Source: Breast Disease - March 28, 2018 Category: Cancer & Oncology Tags: Breast Dis Source Type: research

Synchronous and metachronous breast cancer in Ukraine.
CONCLUSIONS: There should be paid a great attention to synchronous and metachronous breast cancer patients in order to find and provide the best options of their management. This is crucial to continue researches in this field of oncology. PMID: 29504518 [PubMed - in process] (Source: Breast Disease)
Source: Breast Disease - March 8, 2018 Category: Cancer & Oncology Tags: Breast Dis Source Type: research

Metaplastic carcinoma of the breast with mesenchymal differentiation (carcinosarcoma). A unique presentation of an aggressive malignancy and literature review.
Authors: Salemis NS Abstract Metaplastic carcinoma of the breast with mesenchymal differentiation (MCMD), previously known as carcinosarcoma, is a very rare and aggressive tumor that has been recently classified as a subtype of metaplastic breast carcinoma. It accounts for 0.08%-0.2% of all breast cancers, with only a few cases reported in the literature. Histologically, MCMD is characterized by a biphasic pattern of malignant epithelial and sarcomatous components without evidence of a transition zone between the two elements. We herein describe a unique case of metaplastic carcinoma of the breast with chondrosarco...
Source: Breast Disease - March 6, 2018 Category: Cancer & Oncology Tags: Breast Dis Source Type: research

Forkhead box M1 (FOXM1) expression predicts disease free survival and may mediate resistance to chemotherapy and hormonotherapy in male breast cancer.
Authors: Abdeljaoued S, Bettaieb L, Nasri M, Adouni O, Goucha A, Bouzaiene H, Boussen H, Rahal K, Gamoudi A Abstract BACKGROUND: Male breast cancer (MBC) is a rare and neglected disease. Prognostic and predictive factors in MBC are extrapoled from trials conducted on its female counterpart. OBJECTIVE: Since the relationship between the transcription factor Forkhead box M1 (FOXM1) expression and the clinical response to chemotherapy and hormonotherapy in MBC remains unknown, we sought to investigate the predictive value of FOXM1 in MBC. METHODS: FOXM1 expression was assessed in 130 MBC cases. Clinical signif...
Source: Breast Disease - March 6, 2018 Category: Cancer & Oncology Tags: Breast Dis Source Type: research

Isolated metachronous breast metastasis from Renal Cell carcinoma: A report of two cases.
We report two cases of isolated metachronous metastases to breast from renal cell carcinoma. PMID: 29376843 [PubMed - as supplied by publisher] (Source: Breast Disease)
Source: Breast Disease - January 31, 2018 Category: Cancer & Oncology Tags: Breast Dis Source Type: research

Clinico-pathologic disparities of breast cancer in Hispanic/Latina women.
Authors: Nahleh Z, Botrus G, Dwivedi A, Badri N, Otoukesh S, Diab N, Biswas S, Jennings M, Elzamly S Abstract BACKGROUND: Breast cancer is the leading cause of cancer death in Hispanic/Latina women nationwide. Limited cancer research has been conducted in this population. El Paso, Texas is a large border city with a population of around 900,000, of which 85% are Latinos and would provide a suitable setting for this study. The aim of this study is to evaluate ethnic differences and cancer characteristics in Hispanic/latina women with breast cancer. METHODS: After IRB approval, we retrospectively analyzed the var...
Source: Breast Disease - January 31, 2018 Category: Cancer & Oncology Tags: Breast Dis Source Type: research

Phyllodes tumors of the breast: clinicopathological analysis of 106 cases from a single institution.
Authors: Efared B Abstract BACKGROUND: Phyllodes tumors (PT) are uncommon biphasic tumors, accounting for less than 1% of all breast primary neoplasms. They form a wide variety of tumors ranging from benign to malignant. Several histological features are used to grade PT into 3 categories: benign (grade I), borderline (grade II) and malignant (grade III) tumors. The aim of our study was to analyse histolopathological, radiological and clinical features of PT from an experience of a single center. METHODS: It was a retrospective study including 106 patients diagnosed with phyllodes tumors on surgi...
Source: Breast Disease - January 16, 2018 Category: Cancer & Oncology Tags: Breast Dis Source Type: research

Primary breast angiosarcoma - a single institution experience from a tertiary cancer center in South  India.
CONCLUSION: Due to a small number of this malignancy randomized studies are difficult to perform and optimum treatment strategy still need to be defined. PMID: 29286911 [PubMed - as supplied by publisher] (Source: Breast Disease)
Source: Breast Disease - December 31, 2017 Category: Cancer & Oncology Tags: Breast Dis Source Type: research

Cytological diagnosis of crystallizing galactocele - report of an unusual case.
We report this case because of rarity of this condition and to the best of our knowledge, till date only five cases of crystallizing galactocele has been reported in medical literature. PMID: 29286912 [PubMed - as supplied by publisher] (Source: Breast Disease)
Source: Breast Disease - December 31, 2017 Category: Cancer & Oncology Tags: Breast Dis Source Type: research