Screening Family and Psychosocial Risk in Pediatric Migraine and Tension-Type Headache: Validation of the Psychosocial Assessment Tool (PAT).
CONCLUSIONS: The PAT is a promising tool for screening psychosocial risk that could facilitate identification of psychosocial treatment needs among youth with recurrent headache at risk for poor outcomes. PMID: 31318451 [PubMed - as supplied by publisher] (Source: Headache)
Source: Headache - July 18, 2019 Category: Neurology Authors: Law EF, Powers SW, Blume H, Palermo TM Tags: Headache Source Type: research

Getting to the Heart of the Matter: Migraine, Triptans, DHE, Ditans, CGRP Antibodies, First/Second-Generation Gepants, and Cardiovascular Risk.
Abstract PREMISE: The science of migraine pathophysiology has advanced significantly since the 1930's. Imaging techniques, neurochemical analysis, clinical trials, and the clinical experience of providers treating migraine patients have not only sharpened our understanding of the disease, but have also led to the development of novel neural-based targets. Targeted therapies such as calcitonin gene-related peptide (CGRP) antibodies and "Second Generation" CGRP receptor antagonists (Gepants) have not only demonstrated efficacy, but have not resulted in any significant cardiovascular nor other serious adver...
Source: Headache - July 18, 2019 Category: Neurology Authors: Mathew PG, Klein BC Tags: Headache Source Type: research

Headache, Visual Loss, and Encephalopathy Associated With Intravenous Ozone Administration.
PMID: 31310327 [PubMed - as supplied by publisher] (Source: Headache)
Source: Headache - July 16, 2019 Category: Neurology Authors: Tong O, Robbins MS Tags: Headache Source Type: research

Relationship of Migraine and Tension-Type Headache With Hypothyroidism: A Literature Review.
CONCLUSIONS: The existing data are considered inadequate to answer with certainty the relationship between headaches and thyroid disorders. According to our analysis, it seems that suggestions for a possible bidirectional association between headaches and especially migraine and hypothyroidism could exist. It hence lays the foundation for further research into the aforementioned association and its pathogenesis via large prospective multicenter studies. PMID: 31310335 [PubMed - as supplied by publisher] (Source: Headache)
Source: Headache - July 16, 2019 Category: Neurology Authors: Spanou I, Bougea A, Liakakis G, Rizonaki K, Anagnostou E, Duntas L, Kararizou E Tags: Headache Source Type: research

Raynaud's Phenomenon Associated With Calcitonin Gene-Related Peptide Monoclonal Antibody Antagonists.
Abstract Two cases are reported of migraineurs who reported Raynaud's phenomenon (RP) exacerbated while taking monoclonal antibodies to the calcitonin gene-related peptide (CGRP) ligand (fremanezumab and galcanezumab) and 1 case of new onset RP while taking the CGRP receptor antagonist (erenumab). The prevalence of primary and secondary RP, causes of secondary RP, co-morbidity with migraine, and medications which might induce or exacerbate RP are reviewed. The pathophysiology of how CGRP monoclonal antagonists might exacerbate or induce RP is discussed. The cases suggest but do not prove causation. PMID: 3131...
Source: Headache - July 16, 2019 Category: Neurology Authors: Evans RW Tags: Headache Source Type: research

Headache and Hypoglossal Nerve Palsy in a Child With Idiopathic Hypertrophic Pachymeningitis.
PMID: 31294820 [PubMed - as supplied by publisher] (Source: Headache)
Source: Headache - July 11, 2019 Category: Neurology Authors: Hsieh DT, Faux BM, Lotze TE Tags: Headache Source Type: research

Targeting CGRP and 5-HT1F Receptors for the Acute Therapy of Migraine: A Literature Review.
CONCLUSION: Current available therapies have either been nonspecific or had important limitations, including in patients with cardiovascular risk factors. Phase III clinical trials of lasmiditan, rimegepant and ubrogepant all met their primary endpoints, so the options for migraine-targeted acute therapy will likely soon increase. PMID: 31291016 [PubMed - in process] (Source: Headache)
Source: Headache - July 1, 2019 Category: Neurology Authors: Moreno-Ajona D, Chan C, Villar-Martínez MD, Goadsby PJ Tags: Headache Source Type: research

Neuromodulation for the Acute and Preventive Therapy of Migraine and Cluster Headache.
Abstract Headache disorders are among the most common and disabling medical conditions worldwide. Pharmacologic acute and preventive treatments are often insufficient and poorly tolerated, and the majority of patients are unable to adhere to their migraine treatments due to these issues. With improvements in our understanding of migraine and cluster headache pathophysiology, neuromodulation devices have been developed as safe and effective acute and preventive treatment options. In this review, we focus on neuromodulation devices that have been studied for migraine and cluster headache, with special attention to t...
Source: Headache - July 1, 2019 Category: Neurology Authors: Halker Singh RB, Ailani J, Robbins MS Tags: Headache Source Type: research

Emerging Treatment Targets for Migraine and Other Headaches.
Abstract Migraine is a complex disorder that is characterized by an assortment of neurological and systemic effects. While headache is the most prominent feature of migraine, a host of symptoms affecting many physiological functions are also observed before, during, and after an attack. Furthermore, migraineurs are heterogeneous and have a wide range of responses to migraine therapies. The recent approval of calcitonin gene-related-peptide based therapies has opened up the treatment of migraine and generated a renewed interest in migraine research and discovery. Ongoing advances in migraine research have identifie...
Source: Headache - July 1, 2019 Category: Neurology Authors: Bertels Z, Pradhan AAA Tags: Headache Source Type: research

New and Emerging Treatments for the Acute and Preventive Therapy of Migraine and Other Headaches.
PMID: 31291019 [PubMed - in process] (Source: Headache)
Source: Headache - July 1, 2019 Category: Neurology Authors: Schwedt TJ Tags: Headache Source Type: research

Targeting CGRP for the Prevention of Migraine and Cluster Headache: A Narrative Review.
Abstract Calcitonin-gene-related peptide (CGRP), a neuropeptide broadly distributed in neuronal and non-neuronal regions throughout the body, plays a fundamental role in migraine and cluster headache (CH) pathophysiology. CGRP functional blockade alleviates neurogenic inflammation and reduces pain pathway sensitization. Two types of CGRP function-blocking modalities, monoclonal antibodies (MAbs), and small molecules (gepants), have been designed to target the CGRP ligands and CGRP receptors. In this narrative review, we summarized the latest clinical trials on gepants and CGRP function-blocking MAbs for migraine a...
Source: Headache - July 1, 2019 Category: Neurology Authors: Yuan H, Spare NM, Silberstein SD Tags: Headache Source Type: research

Case Report: Shortest Course of Pediatric Paroxysmal Hemicrania.
We describe herein a case with the shortest course of pediatric PH among previously reported cases, and the first case report of Japanese pediatric PH. An 11-year-old boy was referred to our clinic by his primary care physician for a headache evaluation. He had been complaining of severe, sharp, pulsating headache for 5 days. Attacks were restricted to the left side with a duration ranging from 2 to 20 minutes, 20-30 times a day. Attacks were associated with left autonomic symptoms (conjunctival injection, lacrimation, nasal congestion, eyelid edema, and ptosis). Two days after we prescribed indomethacin at 0.9 mg/kg/day, ...
Source: Headache - July 1, 2019 Category: Neurology Authors: Ishii R, Fukazawa R, Takezawa H, Fujii A Tags: Headache Source Type: research

Sodium Divalproate in Low Alternating Daily Doses for Migraine Prevention: A Retrospective Study.
CONCLUSIONS: Despite the retrospective open design, which cannot allow definitive conclusions, SD in low alternating daily doses seems to be effective as with higher doses, but still induce modest weight gain. Controlled studies are necessary to confirm these observations. PMID: 31257584 [PubMed - as supplied by publisher] (Source: Headache)
Source: Headache - July 1, 2019 Category: Neurology Authors: Krymchantowski AV, Krymchantowski AG, Jevoux C Tags: Headache Source Type: research

A Case of Ictal Epileptic Headache in Non Convulsive Status Epilepticus: Not Always, Not Only, a Matter of Pain.
PMID: 31260097 [PubMed - as supplied by publisher] (Source: Headache)
Source: Headache - July 1, 2019 Category: Neurology Authors: Fanella M, Morano A, Fattouch J, Albini M, Basili LM, Avorio F, Cerulli Irelli E, Manfredi M, Giallonardo AT, Di Bonaventura C Tags: Headache Source Type: research

Trigeminal Neuralgia and Charcot-Marie-Tooth Disease: An Intriguing Association. Lessons From a Large Family Case Report and Review of Literature.
CONCLUSION: This report of familial TN in CMT with identified MPZ mutation highlighted specific characteristics of this association. Considered as a rare association in the literature, it may be underestimated and the clinician should be aware of its specific pattern, including earlier age of onset, bilateral presentation, and poor tolerance to preventive treatments. PMID: 31222744 [PubMed - as supplied by publisher] (Source: Headache)
Source: Headache - June 20, 2019 Category: Neurology Authors: Méreaux JL, Lefaucheur R, Hebant B, Guégan-Massardier E, Grangeon L Tags: Headache Source Type: research

The Association Between Parental Migraine and Infant Colic: A Cross-Sectional, Web-Based, U.S. Survey Study.
CONCLUSIONS: Mothers with migraine are more likely to have a baby with colic, while fathers with migraine are not. Further research is needed to determine the mechanisms underlying these findings. In the meantime, clinicians may wish to counsel parents with a maternal history of migraine about the increased possibility of having a colicky infant and provide resources and education about infant crying. PMID: 31222745 [PubMed - as supplied by publisher] (Source: Headache)
Source: Headache - June 20, 2019 Category: Neurology Authors: Gelfand AA, Buse DC, Cabana MD, Grimes B, Goadsby PJ, Allen IE Tags: Headache Source Type: research

Evaluating the Psychometric Properties of the Migraine Functional Impact Questionnaire (MFIQ).
The objective of this study was to conduct item analyses informing item reduction and scoring, and to evaluate the psychometric properties of the MFIQ. METHODS: In a prospective, observational study, adults with migraine completed the MFIQ as well as additional clinical and PRO instruments, including the Headache Impact Test (HIT-6TM ), Patient-Reported Outcomes Measurement Information System Physical Function Short Form 10a (PROMIS-PF), Migraine-Specific Quality-of-Life Questionnaire (MSQ), and Patient Global Rating of Change (PGIC). Item-level evaluation, item response theory (IRT), and factor analysis were used to ...
Source: Headache - June 5, 2019 Category: Neurology Authors: Kawata AK, Hareendran A, Shaffer S, Mannix S, Thach A, Desai P, Mikol DD, Ortmeier B, Bayliss M, Buse DC Tags: Headache Source Type: research

Improving the Patient Experience With Migraine Camp, a One-Day Group Intervention for Adolescents With Chronic Headache and Their Parents.
Abstract Though chronic migraine is actually common in adolescents, living with constant headache can be isolating for both patients and their families. As an outgrowth of clinical care, we developed the Miles for Migraine Youth Camp, a recurring 1-day event for adolescents with chronic headache and their parents. Migraine Camp was developed to provide expanded headache education, teach coping strategies for living with chronic pain, and encourage development of a supportive community for adolescents living with chronic headache disorders and their families. The creation and curriculum of the Camps at the Universi...
Source: Headache - June 5, 2019 Category: Neurology Authors: Hall AL, Karvounides D, Gelfand AA, Mankin H, Kessel S, Corroo J, Malavolta CP, Pezzuto T, Chadehumbe M, Szperka CL Tags: Headache Source Type: research

Anxiety Sensitivity as a Risk Indicator for Anxiety, Depression, and Headache Severity in Women With Migraine.
Abstract OBJECTIVE: The primary aim of this exploratory study was to assess the relationship between anxiety sensitivity and emotional disorders, migraine characteristics, and migraine-related fear and avoidance behaviors in women with probable migraine. BACKGROUND: Anxiety and depressive disorders are the most frequent comorbid psychiatric conditions in migraine, particularly in women; however, the underlying reasons for these comorbidities are uncertain. Anxiety sensitivity, the tendency to catastrophically appraise anxiety and bodily sensations in terms of their physical, social, or cognitive consequences,...
Source: Headache - June 5, 2019 Category: Neurology Authors: Farris SG, Burr EK, Abrantes AM, Thomas JG, Godley FA, Roth JL, Lipton RB, Pavlovic JM, Bond DS Tags: Headache Source Type: research

Carotid Cavernous Fistula Mimicking Hemicrania Continua: A Case Report.
CONCLUSION: Alternative, and perhaps less common, causes of headache should be considered when the clinical presentation is atypical or does not clearly fulfill diagnostic criteria for primary headache disorders. Carotid cavernous fistulas should be included within this differential, and represent a potentially treatable and reversible cause of otherwise refractory headache. PMID: 31166017 [PubMed - as supplied by publisher] (Source: Headache)
Source: Headache - June 5, 2019 Category: Neurology Authors: Arnold Fiebelkorn C, Lanzino G, Chen JJ, Brinjikji W, Eckel LJ, Boes CJ Tags: Headache Source Type: research

Characterization of Dizziness After Lasmiditan Usage: Findings From the SAMURAI and SPARTAN Acute Migraine Treatment Randomized Trials.
Abstract TRIAL DESIGN: SAMURAI and SPARTAN were double-blind, placebo-controlled Phase 3 studies conducted in the United States, as well as the United Kingdom and Germany (SPARTAN only). Individuals with migraine were randomized to receive oral lasmiditan 50 mg (SPARTAN only), 100 mg, 200 mg, or placebo within 4 hours of onset of a migraine attack. The aim of this analysis was to characterize dizziness reported with lasmiditan treatment. METHODS: Data from SAMURAI and SPARTAN were pooled for the current post hoc analyses. Onset time and duration of dizziness were analyzed using descri...
Source: Headache - June 1, 2019 Category: Neurology Authors: Tepper SJ, Krege JH, Lombard L, Asafu-Adjei JK, Dowsett SA, Raskin J, Buchanan AS, Friedman DI Tags: Headache Source Type: research

Evidence-Based Integrative Treatments for Headache.
PMID: 31144297 [PubMed - in process] (Source: Headache)
Source: Headache - June 1, 2019 Category: Neurology Authors: Kuruvilla D, Wells RE Tags: Headache Source Type: research

@HeadacheJournal Tweets On.
PMID: 31144298 [PubMed - in process] (Source: Headache)
Source: Headache - June 1, 2019 Category: Neurology Authors: Robbins MS, Shokrian N, Schwedt TJ, Houle TT, Roberts J Tags: Headache Source Type: research

James W. Lance MD.
PMID: 31144299 [PubMed - in process] (Source: Headache)
Source: Headache - June 1, 2019 Category: Neurology Authors: Goadsby PJ Tags: Headache Source Type: research

Chronobiology and Sleep in Cluster Headache.
Abstract BACKGROUND: Cluster headache attacks follow a striking circadian rhythm with an intriguing influence of sleep. We aim to investigate differences in sleep quality, chronotype, and the ability to alter individual sleep rhythms in episodic and chronic cluster headache patients vs controls. METHODS: Cluster headache patients and non-headache controls from the Dutch Leiden University Cluster headache neuro-Analysis program aged 18 and above completed web-based questionnaires in a cross-sectional study. RESULTS: A total of 478 episodic, 147 chronic cluster headache patients and 367 controls participat...
Source: Headache - May 31, 2019 Category: Neurology Authors: de Coo IF, van Oosterhout WPJ, Wilbrink LA, van Zwet EW, Ferrari MD, Fronczek R Tags: Headache Source Type: research

Greater Occipital Nerve Infiltration During Pregnancy in Cluster Headache: A Case Report.
PMID: 31106401 [PubMed - as supplied by publisher] (Source: Headache)
Source: Headache - May 20, 2019 Category: Neurology Authors: Asioli GM, Merli E, Favoni V, Sartori A, Pierangeli G, Cevoli S Tags: Headache Source Type: research

Reduced Short-Latency Afferent Inhibition Indicates Impaired Sensorimotor Integrity During Migraine Attacks.
CONCLUSION: Pronounced decrease in SAI during preictal and ictal periods in migraine was shown for the first time. Instead of inhibition to a conditioned stimulus, facilitation in the sensorimotor cortex was detected both ictally and preictally. Preictal SAI results suggest the presence of increased excitability state several hours prior to the headache phase. This phenomenon could be related to the cortical hyperresponsivity to sensory stimuli and cognitive disturbances accompanying migraine attacks as SAI is modulated by cholinergic activity. PMID: 31106418 [PubMed - as supplied by publisher] (Source: Headache)
Source: Headache - May 20, 2019 Category: Neurology Authors: Alaydin HC, Vuralli D, Keceli Y, Can E, Cengiz B, Bolay H Tags: Headache Source Type: research

Neuralgia and Myself.
PMID: 31077352 [PubMed - as supplied by publisher] (Source: Headache)
Source: Headache - May 11, 2019 Category: Neurology Authors: Roses S Tags: Headache Source Type: research

Vestibular Neuroscience for the Headache Specialist.
CONCLUSIONS: The vestibular system is not just about balance; this should be taken into account by clinicians as they assess their patients' associated non-headache symptoms. There is a co-occurrence of migraine and vestibular-based problems and a confluence of disciplines relevant to vestibular migraine. PMID: 31077365 [PubMed - as supplied by publisher] (Source: Headache)
Source: Headache - May 11, 2019 Category: Neurology Authors: Balaban CD, Black RD, Silberstein SD Tags: Headache Source Type: research

Remote Electrical Neuromodulation (REN) Relieves Acute Migraine: A Randomized, Double-Blind, Placebo-Controlled, Multicenter Trial.
Abstract OBJECTIVE: To assess the efficacy and safety of a remote electrical neuromodulation (REN) device for the acute treatment of migraine. BACKGROUND: There is a significant unmet need for novel effective well-tolerated acute migraine treatments. REN is a novel acute migraine treatment that stimulates upper arm peripheral nerves to induce conditioned pain modulation - an endogenous analgesic mechanism in which conditioning stimulation inhibits pain in remote body regions. A recent pilot study showed that REN can significantly reduce headache. We have conducted a randomized, double-blind, sham-controlled s...
Source: Headache - May 9, 2019 Category: Neurology Authors: Yarnitsky D, Dodick DW, Grosberg BM, Burstein R, Ironi A, Harris D, Lin T, Silberstein SD Tags: Headache Source Type: research

Pregnancy, Birth, Neonatal, and Postnatal Neurological Outcomes After Pregnancy With Migraine.
CONCLUSIONS: Women with migraine and their offspring have greater risks of several adverse pregnancy outcomes than women without migraine. PMID: 31069791 [PubMed - as supplied by publisher] (Source: Headache)
Source: Headache - May 8, 2019 Category: Neurology Authors: Skajaa N, Szépligeti SK, Xue F, Sørensen HT, Ehrenstein V, Eisele O, Adelborg K Tags: Headache Source Type: research

Evaluating Mean Level and Within-Person Consistency in Migraine Pain Intensity and Migraine-Related Disability for AVP-825 vs Oral Sumatriptan: Results from the COMPASS Study, A Randomized Trial.
Abstract BACKGROUND: Consistency of response across multiple attacks is typically measured as the proportion of study participants who achieve a categorical endpoint over a specified number of attacks (ie, 2-hour pain-free response in 2 of 3 attacks). We applied a novel analytic approach for measuring consistency of response in the acute treatment of episodic migraine using data from the COMPASS study. METHODS: The COMPASS study (NCT01667679) was a multiple attack crossover study which compared AVP-825, a Breath Powered® intranasal delivery system for low-dose sumatriptan powder (22 mg), with 100-mg oral ...
Source: Headache - May 7, 2019 Category: Neurology Authors: McGinley JS, Buse DC, Shulman KJ, Wirth RJ, Hugentobler E, Lipton RB Tags: Headache Source Type: research

Preliminary Evidence that Melatonin Is not a Biomarker With Children and Adolescents With Episodic Migraine.
CONCLUSION: While urinary melatonin metabolites do not predict migraine attacks in children and adolescents overall, they may be predictive in those who experience premonitory phase symptoms as part of their migraine attacks. PMID: 31054199 [PubMed - as supplied by publisher] (Source: Headache)
Source: Headache - May 3, 2019 Category: Neurology Authors: Berger A, Litwin J, Allen IE, Qubty W, Irwin S, Waung M, Gelfand AA Tags: Headache Source Type: research

Effects of MTHFR C677T and A1298C Polymorphisms on Migraine Susceptibility: A Meta-Analysis of 26 Studies.
CONCLUSIONS: Our meta-analysis suggested that allele 677T in MTHFR C677T polymorphism might be a genetic risk factor for MA in Caucasians, and genotype 1298CC might contribute to MO susceptibility. PMID: 31045246 [PubMed - as supplied by publisher] (Source: Headache)
Source: Headache - May 2, 2019 Category: Neurology Authors: Liu L, Yu Y, He J, Guo L, Li H, Teng J Tags: Headache Source Type: research

Assessing and Interpreting Reliability.
PMID: 31032914 [PubMed - in process] (Source: Headache)
Source: Headache - May 1, 2019 Category: Neurology Authors: Turner DP, Houle TT Tags: Headache Source Type: research

We Still Do Not Know Whether Topical Ambroxol Is Effective in Classical Trigeminal Neuralgia.
PMID: 31032915 [PubMed - in process] (Source: Headache)
Source: Headache - May 1, 2019 Category: Neurology Authors: Ziegeler C, May A Tags: Headache Source Type: research

Episodic and Chronic Migraine in Primary Care.
Abstract OBJECTIVE: To inform migraine care model development by assessing differences between patients with chronic migraine (CM) and episodic migraine (EM) in the current state of treatment, disability, patient satisfaction, and quality improvement opportunities. BACKGROUND: Efficient and focused use of scarce resources will be needed to address challenges within large populations of migraine patients. METHODS: We deployed a cross-sectional survey study of randomly selected migraine patients within a community primary care practice. RESULTS: There were 516 survey respondents (516/1804 [30%] respon...
Source: Headache - April 29, 2019 Category: Neurology Authors: Young NP, Philpot LM, Vierkant RA, Rosedahl JK, Upadhyaya SG, Harris A, Ebbert JO Tags: Headache Source Type: research

Calcitonin Gene-Related Peptide Modulators - The History and Renaissance of a New Migraine Drug Class.
Abstract Several lines of evidence pointed to an important role for CGRP in migraine. These included the anatomic colocalization of CGRP and its receptor in sensory fibers innervating pain-producing meningeal blood vessels, its release by trigeminal stimulation, the observation of elevated CGRP in the cranial circulation during migraine with normalization concomitant with headache relief by sumatriptan, and translational studies with intravenous (IV) CGRP that evoked migraine only in migraineurs. The development of small molecule CGRP receptor antagonists (CGRP-RAs) that showed clinical antimigraine efficacy acute...
Source: Headache - April 25, 2019 Category: Neurology Authors: Hargreaves R, Olesen J Tags: Headache Source Type: research

High School Start Time and Migraine Frequency in High School Students.
Abstract OBJECTIVE: To investigate whether later high school start time is associated with lower migraine frequency in high school students with migraine. BACKGROUND: Adequate sleep is thought to be important in managing adolescent migraine. The American Academy of Sleep Medicine recommends teenagers sleep ≥8 hours/night. Adolescents have a physiologically delayed sleep phase, going to bed, and waking later than children and adults. The American Academy of Pediatrics (AAP) accordingly recommends high schools start no earlier than 8:30 AM. METHODS: Cross-sectional observational study of U.S. ...
Source: Headache - April 24, 2019 Category: Neurology Authors: Gelfand AA, Pavitt S, Greene K, Szperka CL, Irwin S, Grimes B, Allen IE Tags: Headache Source Type: research

Psychosocial and Demographic Characteristics of Children and Adolescents With Headache Presenting for Treatment in a Headache Infusion Center.
CONCLUSIONS: Our findings support the disabling nature of migraine among children and adolescents, with higher levels of disability and lower quality of life reported in the group of patients utilizing infusion treatment. Developing concrete treatment plans and goals combined with bio-behavioral therapy are necessary to reduce functional disability and increase quality of life among these patients. Awareness of this patient group's pain-related coping strategies may help health care providers tailor treatment recommendations and develop or refine cognitive-behavioral headache treatment techniques. PMID: 31008518 ...
Source: Headache - April 22, 2019 Category: Neurology Authors: Woods K, Ostrowski-Delahanty S, Cieplinski T, Winkelman J, Polk P, Victorio MC Tags: Headache Source Type: research

Assessment of the Olfactory Function in Patients With Idiopathic Intracranial Hypertension Using the Sniffin' Sticks Test: A Case-Control Study.
Abstract OBJECTIVE: Despite the lack of recognition in clinical practice, there is increasing evidence that patients with idiopathic intracranial hypertension may suffer from hyposmia. The current case-control study aims to evaluate olfactory dysfunction in a large series of patients with idiopathic intracranial hypertension. METHODS: All subjects, 44 idiopathic intracranial hypertension patients and 57 healthy controls, underwent olfactory function assessment using standardized "Sniffin' Sticks" test at a tertiary referral center of a university hospital. Threshold, discrimination, identification, ...
Source: Headache - April 18, 2019 Category: Neurology Authors: Samancı B, Samancı Y, Şen C, Şahin E, Sezgin M, Kocasoy Orhan E, Orhan KS, Baykan B Tags: Headache Source Type: research

The Efficacy and Safety of Prochlorperazine in Patients With Acute Migraine: A Systematic Review and Meta-Analysis.
CONCLUSIONS: For adult patients with acute migraine, PCP could effectively abort the acute attack and reduce the request for rescue analgesia in the ED. However, compared with placebo, PCP could increase the risk of adverse events. PMID: 30990883 [PubMed - as supplied by publisher] (Source: Headache)
Source: Headache - April 16, 2019 Category: Neurology Authors: Golikhatir I, Cheraghmakani H, Bozorgi F, Jahanian F, Sazgar M, Montazer SH Tags: Headache Source Type: research

Teaching Images in Headache: Concurrent Hypercalcemia-Induced Reversible Cerebral Vasoconstriction Syndrome and Posterior Reversible Encephalopathy Syndrome.
PMID: 30985912 [PubMed - as supplied by publisher] (Source: Headache)
Source: Headache - April 15, 2019 Category: Neurology Authors: Chan TLH, Mayich M, Budhram A, Sallam Y, Becker WJ Tags: Headache Source Type: research

Clinical Features of Patients With Spontaneous Intracranial Hypotension Complicated With Bilateral Subdural Fluid Collections.
CONCLUSION: Bilateral subdural fluid collections due to underlying SIH is associated with young age (≤55 years old), no underlying diseases, smaller amount of fluid collections (≤22.08 mm of depth), and radiological findings of brain sagging or pseudo-subarachnoid hemorrhages. PMID: 30985923 [PubMed - as supplied by publisher] (Source: Headache)
Source: Headache - April 15, 2019 Category: Neurology Authors: Kim JH, Roh H, Yoon WK, Kwon TH, Chong K, Hwang SY, Kim JH Tags: Headache Source Type: research

A Case of Reversible Cerebral Vasoconstriction Syndrome Triggered by High-Dose Methotrexate in a Boy With Lymphoma.
We report the first case of a 17-year-old Chinese student with a thunderclap headache after administration of high-dose methotrexate during the treatment of extranodal natural killer/T-cell lymphoma. Brain magnetic resonance angiography showed segmental constriction of the right anterior cerebral artery A1 segment, combined with nonaneurysmal cortical subarachnoid hemorrhage and vasogenic brain edema in brain magnetic resonance imaging. Cerebral images became normal 6 weeks later. DISCUSSION: MTX is associated with a variety of neurological toxicities, including aseptic meningitis, transverse myelopathy, acute an...
Source: Headache - April 15, 2019 Category: Neurology Authors: Wang X, Zhang Y, You H, Zhu T, Zhou D Tags: Headache Source Type: research

CGRP and the Trigeminal System in Migraine.
CONCLUSIONS: CGRP plays an essential role in the pathophysiology of migraine. Treatments that interfere with the functioning of CGRP in the peripheral trigeminal system are effective against migraine. Blocking sensitization of the trigeminal nerve by attenuating CGRP activity in the periphery may be sufficient to block a migraine attack. Additionally, the potential exists that this therapeutic strategy may also alleviate cluster headache as well. PMID: 30982963 [PubMed - as supplied by publisher] (Source: Headache)
Source: Headache - April 14, 2019 Category: Neurology Authors: Iyengar S, Johnson KW, Ossipov MH, Aurora SK Tags: Headache Source Type: research

Safety and Tolerability of Fremanezumab for the Prevention of Migraine: A Pooled Analysis of Phases 2b and 3 Clinical Trials.
CONCLUSIONS: Fremanezumab is a generally safe and well-tolerated preventive therapy for migraine in adults. PMID: 30977520 [PubMed - as supplied by publisher] (Source: Headache)
Source: Headache - April 12, 2019 Category: Neurology Authors: Silberstein SD, McAllister P, Ning X, Faulhaber N, Lang N, Yeung P, Schiemann J, Aycardi E, Cohen JM, Janka L, Yang R Tags: Headache Source Type: research

An Integrative Cognitive Behavioral Therapy Program for Adults With Migraine: A Feasibility Study.
CONCLUSIONS: The idea of combining several approaches of behavioral therapy into a specific treatment program for migraine seems to be feasible and promising. A randomized controlled trial to determine the efficacy of our program is currently running. PMID: 30970172 [PubMed - as supplied by publisher] (Source: Headache)
Source: Headache - April 10, 2019 Category: Neurology Authors: Klan T, Liesering-Latta E, Gaul C, Martin PR, Witthöft M Tags: Headache Source Type: research

Cluster Headache in Subjects With Substance Use Disorder: A Case Series and a Review of the Literature.
CONCLUSIONS: We have found a CH prevalence of 0.9% in our studied population, while it is estimated at 0.1% in the general population. The coexistence of cluster headache and addiction behaviors reflects possible common neurobiological pathways, which would include the hypothalamus. Research could be conducted on the potential of hypothalamic therapeutic targets. PMID: 30957220 [PubMed - as supplied by publisher] (Source: Headache)
Source: Headache - April 7, 2019 Category: Neurology Authors: Ponté C, Giron A, Crequy M, Lapeyre-Mestre M, Fabre N, Salles J Tags: Headache Source Type: research

Did Going North Give Us Migraine? An Evolutionary Approach on Understanding Latitudinal Differences in Migraine Epidemiology.
rdi M Abstract This commentary discusses a recent publication by evolutionary biologists with strong implications for migraine experts. The Authors showed that a gene polymorphism associated with migraine gave our ancestors an evolutionary advantage when colonizing northern, and thus colder, territories. They then highlight that the prevalence of migraine may differ among countries because of climatic adaptation. These results may prove useful in planning both epidemiological and physiological studies in the field of migraine. PMID: 30957222 [PubMed - as supplied by publisher] (Source: Headache)
Source: Headache - April 7, 2019 Category: Neurology Authors: Viganò A, Manica A, Di Piero V, Leonardi M Tags: Headache Source Type: research