Abstracts and Citations.
PMID: 32654113 [PubMed - as supplied by publisher] (Source: Headache)
Source: Headache - July 11, 2020 Category: Neurology Authors: Taylor FR, Cooper W, Kaniecki RG Tags: Headache Source Type: research

Patient with Cluster Headache and Harlequin Sign - Related or Not?
CONCLUSION: This case reports a rare combination of cluster headache and harlequin sign that warrants further testing to exclude pathology in the brain, neck or mediastinum. It also illustrates the underlying anatomy and physiology of the autonomic nervous system. PMID: 32654114 [PubMed - as supplied by publisher] (Source: Headache)
Source: Headache - July 11, 2020 Category: Neurology Authors: Van Oosterhout WPJ Tags: Headache Source Type: research

Moving the Needle, the Clinical Perspective.
PMID: 32654126 [PubMed - as supplied by publisher] (Source: Headache)
Source: Headache - July 11, 2020 Category: Neurology Authors: Schim J Tags: Headache Source Type: research

Types of Triggers in Migraine - Factor Structure of the Headache Triggers Sensitivity and Avoidance Questionnaire and Development of a New Short Form (HTSAQ-SF).
t M Abstract OBJECTIVE: To examine the factor structure of the Headache Triggers Sensitivity and Avoidance Questionnaire (HTSAQ) and its German version (HTSAQ-G), in order to identify potential different types of triggers. Furthermore, a short form of the questionnaire was developed. BACKGROUND: The HTSAQ includes 24 of the most commonly reported headache triggers (eg, stress, odors, lack of sleep). Both the HTSAQ and HTSAQ-G appeared to be reliable and valid measures of sensitivity to and avoidance of headache triggers. METHODS: In a cross-country collaboration, data from 2 cross-sectional studies inclu...
Source: Headache - July 11, 2020 Category: Neurology Authors: Caroli A, Klan T, Gaul C, Kubik SU, Martin PR, Witthöft M Tags: Headache Source Type: research

COVID-19 and Headache Medicine: A Narrative Review of Non-Steroidal Anti-Inflammatory Drug (NSAID) and Corticosteroid Use.
CONCLUSION: Scientific information regarding the COVID-19 pandemic is constantly evolving, and limited or contradictory information can lead to confusion for both patients and clinicians. It is recommended that prior to prescribing non-steroidal anti-inflammatory drugs and steroids for the treatment of headache, clinicians have open discussions with their patients about the potential risks and benefits of using these medications during the COVID-19 pandemic. This manuscript summarizes the currently available evidence and understanding about these risks and benefits to help clinicians navigate such discussions. PMID: 3...
Source: Headache - July 10, 2020 Category: Neurology Authors: Arca KN, Smith JH, Chiang CC, Starling AJ, Robertson CE, Halker Singh RB, Schwedt TJ, Kissoon NR, Garza I, Rozen TD, Boes CJ, Whealy MA, VanderPluym JH Tags: Headache Source Type: research

Triggers of Primary Headaches: Issues and Pathways Forward.
Abstract The triggers of primary headaches have considerable significance for our understanding and management of headache and migraine. Triggers explain the variance in headaches - why they occur when they do. Trigger management is generally viewed as an important component of a comprehensive treatment approach for headaches. Historically, however, triggers have not had a prominent place in the headache literature. This situation began to change 20 to 30 years ago, and the pace of change has increased exponentially in recent times. Nevertheless, the field is beset with issues that have held it back from achi...
Source: Headache - July 10, 2020 Category: Neurology Authors: Martin PR Tags: Headache Source Type: research

Evaluation of 2-Hour Post-Dose Efficacy of Lasmiditan for the Acute Treatment of Difficult-to-Treat Migraine Attacks.
CONCLUSIONS: Efficacy of lasmiditan 200 and 100 mg for headache pain freedom and most bothersome symptom freedom at 2 hours post-treatment was generally not influenced by the individual patient characteristics, migraine disease history, or migraine attack characteristics that were analyzed. In the analyses of difficult-to-treat subgroups, patients receiving lasmiditan achieved greater responses (2-hour headache pain freedom and most bothersome symptom freedom) vs placebo recipients. PMID: 32634275 [PubMed - as supplied by publisher] (Source: Headache)
Source: Headache - July 7, 2020 Category: Neurology Authors: Tepper SJ, Vasudeva R, Krege JH, Rathmann SS, Doty E, Vargas BB, Magis D, Komori M Tags: Headache Source Type: research

Serum Homocysteine, Pyridoxine, Folate, and Vitamin B12 Levels in Migraine: Systematic Review and Meta-Analysis.
CONCLUSIONS: Our results suggest that there is a possible link between migraine, mainly MA, and elevated serum Hcy. PMID: 32615014 [PubMed - as supplied by publisher] (Source: Headache)
Source: Headache - July 2, 2020 Category: Neurology Authors: Liampas I, Siokas V, Mentis AA, Aloizou AM, Dastamani M, Tsouris Z, Aslanidou P, Brotis A, Dardiotis E Tags: Headache Source Type: research

Mechanism of Action of OnabotulinumtoxinA in Chronic Migraine: A Narrative Review.
CONCLUSION: OnabotulinumtoxinA likely acts via sensory mechanisms to treat chronic migraine. PMID: 32602955 [PubMed - as supplied by publisher] (Source: Headache)
Source: Headache - June 30, 2020 Category: Neurology Authors: Burstein R, Blumenfeld AM, Silberstein SD, Manack Adams A, Brin MF Tags: Headache Source Type: research

Cranial Autonomic Symptoms of Migraine in Japan: Prospective Study of 373 Migraine Patients at a Tertiary Headache Center.
CONCLUSION: CAS in patients with migraine is common not only in Caucasians but also in Asians. Central sensitization seems to contribute more than peripheral sensitization to CAS manifestation, and osmophobia might be noteworthy among Asian patients with migraine. To avoid a misdiagnosis, we emphasize the need for comments on CAS in the international classification of headache disorders migraine criteria. PMID: 32592512 [PubMed - as supplied by publisher] (Source: Headache)
Source: Headache - June 27, 2020 Category: Neurology Authors: Danno D, Wolf J, Ishizaki K, Kikui S, Yoshikawa H, Takeshima T Tags: Headache Source Type: research

A Randomized Sham-Controlled Cross-Over Study on the Short-Term Effect of Non-Invasive Cervical Vagus Nerve Stimulation on Spinal and Supraspinal Nociception in Healthy Subjects.
CONCLUSIONS: The present study does not support an acute effect of nVNS on descending pain inhibition, pain intensity perception or supraspinal nociception in healthy adults. However, there was a small effect on pain unpleasantness during nVNS, suggesting that nVNS may preferentially act on affective, not somatosensory pain components. PMID: 32592516 [PubMed - as supplied by publisher] (Source: Headache)
Source: Headache - June 27, 2020 Category: Neurology Authors: Alt LK, Wach K, Liebler EJ, Straube A, Ruscheweyh R Tags: Headache Source Type: research

Open-Label, Multi-Dose, Pilot Safety Study of Injection of OnabotulinumtoxinA Toward the Otic Ganglion for the Treatment of Intractable Chronic Cluster Headache.
CONCLUSIONS: Injection with BTA toward the OG appears to be safe. We did not find a statistically significant reduction in the number of attacks per week at month 2 after injection compared to the baseline. This study suggests that the OG is not an important target for the treatment of chronic cluster headache. A future study employing more precise targeting of the OG may be indicated. PMID: 32583902 [PubMed - as supplied by publisher] (Source: Headache)
Source: Headache - June 25, 2020 Category: Neurology Authors: Crespi J, Bratbak D, Dodick DW, Matharu M, Solheim O, Gulati S, Berntsen EM, Tronvik E Tags: Headache Source Type: research

Evaluation of the Pharmacokinetic Interaction of Ubrogepant Coadministered With Sumatriptan and of the Safety of Ubrogepant With Triptans.
CONCLUSIONS: Although there were slight alterations in ubrogepant pharmacokinetic parameters when coadministered with sumatriptan, such changes are expected to have minimal clinical relevance, especially because no changes were seen in sumatriptan area under the curve and maximum plasma concentration when coadministered with ubrogepant. Coadministration of ubrogepant with sumatriptan was well tolerated in healthy participants in the Phase 1 study, and coadministration of ubrogepant with triptans was well tolerated in participants with migraine in the Phase 3 trials. No new safety concerns for ubrogepant were identified acr...
Source: Headache - June 23, 2020 Category: Neurology Authors: Jakate A, Boinpally R, Butler M, Lu K, McGeeney D, Periclou A Tags: Headache Source Type: research

Alterations in Functional Connectivity During Different Phases of the Triggered Migraine Attack.
Abstract OBJECTIVE: To understand the changes in functional connectivity between brain areas of potential importance in migraine during different phases of the attack. BACKGROUND: Migraine is a symptomatically heterogeneous disorder. Understanding the possible changes in brain function and, therefore, neurobiology during different phases of the migraine attack is important in developing disease biomarkers and advancing therapeutics. DESIGN: Randomized, double-blind, placebo-controlled, multi-visit experimental study. METHODS: Subjects aged 18-50 years with migraine with and without aura (≤22...
Source: Headache - June 22, 2020 Category: Neurology Authors: Karsan N, Bose PR, O'Daly O, Zelaya FO, Goadsby PJ Tags: Headache Source Type: research

Headache Virtual Visit Toolbox: The Transition From Bedside Manners to Webside Manners.
Abstract The COVID-19 health emergency has led many Headache providers to transition to virtual care overnight without preparation. We review our experience and discuss tips to bring humanity to the virtual visits. PMID: 32562268 [PubMed - as supplied by publisher] (Source: Headache)
Source: Headache - June 19, 2020 Category: Neurology Authors: Begasse de Dhaem O, Bernstein C Tags: Headache Source Type: research

Headaches Due to Personal Protective Equipment During COVID-19 Pandemic: A Comment.
PMID: 32557578 [PubMed - as supplied by publisher] (Source: Headache)
Source: Headache - June 17, 2020 Category: Neurology Authors: Goh Y, Ong JJY, Bharatendu C, Tan BYQ, Sharma VK Tags: Headache Source Type: research

S100B and NSE in Cluster Headache - Evidence for Glial Cell Activation?
en RH Abstract OBJECTIVE: Neuronal-specific enolase (NSE) and protein S100B have gained considerable interest as the markers of CNS injury, glial cell activation, and/or blood-brain barrier (BBB) disruption. No studies have investigated NSE and S100B in cluster headache (CH), but these biomarkers could contribute to the understanding of CH. METHODS: Patients with episodic CH in bout (eCHa), in remission (eCHr), and chronic CH (cCH) were included in this randomized, double-blind, placebo-controlled, 2-way cross-over provocation study carried out at the Danish Headache Center. The primary endpoints included (1)...
Source: Headache - June 16, 2020 Category: Neurology Authors: Snoer AH, Vollesen ALH, Beske RP, Guo S, Hoffmann J, Jørgensen NR, Martinussen T, Ashina M, Jensen RH Tags: Headache Source Type: research

Endolymphatic Hydrops Secondary to Spontaneous Intracranial Hypotension.
CONCLUSIONS: Audio vestibular manifestations mimicking Menière's disease in spontaneous intracranial hypotension could be explained by endolymphatic hydrops, which can be detected using dedicated magnetic resonance imaging sequences. PMID: 32542657 [PubMed - as supplied by publisher] (Source: Headache)
Source: Headache - June 16, 2020 Category: Neurology Authors: Poillon G, Hautefort C, Levy D, Eliezer M Tags: Headache Source Type: research

What are Headache Smartphone Application (App) Users Actually Looking for in Apps: A Qualitative Analysis of App Reviews to Determine a Patient Centered Approach to Headache Smartphone Apps.
DISCUSSION: A user-centered design with the ability to (1) customize key features including headache characteristics, potential triggers, and treatments, (2) assess trends in data, and (3) view and export data would best optimize headache smartphone applications based on consumer preference. PMID: 32535915 [PubMed - as supplied by publisher] (Source: Headache)
Source: Headache - June 13, 2020 Category: Neurology Authors: Minen MT, Gumpel T, Ali S, Sow F, Toy K Tags: Headache Source Type: research

Cross-Cultural Headache Care Within the United States: Speaking the Unspoken.
PMID: 32535945 [PubMed - as supplied by publisher] (Source: Headache)
Source: Headache - June 13, 2020 Category: Neurology Authors: Charleston L Tags: Headache Source Type: research

Cognitive Networks Disarrangement in Patients With Migraine Predicts Cutaneous Allodynia.
CONCLUSION: We suggest that DMN and CEN FC abnormalities as well as CC microstructural changes could represent a prognostic imaging biomarker able to identify migraine patients more prone to experiencing CA and therefore, more inclined to chronic migraine. In the new pharmacological scenario, it would be useful to address therapeutic resources to specific migraine populations with a high risk of more severe clinical phenotype. PMID: 32533895 [PubMed - as supplied by publisher] (Source: Headache)
Source: Headache - June 13, 2020 Category: Neurology Authors: Russo A, Silvestro M, Trojsi F, Bisecco A, De Micco R, Caiazzo G, Di Nardo F, Esposito F, Tessitore A, Tedeschi G Tags: Headache Source Type: research

Should we adapt the prescription criteria for specific treatments for migraine due to the Covid-19 pandemic?
uiu J Abstract We have read with great interest the article by Ali et al regarding the delay in Onabotulinumtoxin (OBT) during the COVID-19 pandemic in three patients published in Headache (1). During the pandemic, Headache units have had to adapt by replacing face-to-face care with phone calls or visits using electronic means. Unfortunately, in many cases this has led to deterioration in patient treatment (2). As discussed in the article by Ali et al, many patients understand the situation, but as spread of COVID-19 and the associated lockdown extend over time, their viewpoint is prone to shift (1). PMID: 32...
Source: Headache - June 11, 2020 Category: Neurology Authors: Porta-Etessam J, Gonzalez-Garcia N, Matias-Guiu JA, Montero-Escribano P, Matías-Guiu J Tags: Headache Source Type: research

COVID19 and Headache: A Primer for Trainees.
CONCLUSIONS: Limited information exists regarding the mechanisms and timing of headache in patients with COVID19, though causes relate to plausible direct viral invasion of the nervous system as well as the cytokine release syndrome. Though headache care in the COVID19 era requires alterations, the improved preventive treatment options now available and evidence for feasibility and safety of telemedicine well positions clinicians to take care of such patients, especially in the COVID19 epicenter of New York City. PMID: 32521039 [PubMed - as supplied by publisher] (Source: Headache)
Source: Headache - June 10, 2020 Category: Neurology Authors: Bobker SM, Robbins MS Tags: Headache Source Type: research

Headache as the Presenting Symptom in 2 Patients with COVID-19 and a History of Migraine: 2 Case Reports.
Abstract The Coronavirus disease 2019 (COVID-19) pandemic has now affected more than five million people globally. Typical symptoms include fever, cough, and shortness of breath. Patients with underlying medical comorbidities such as cardiovascular disease and diabetes are more likely to become severely ill. To date there is limited information on how COVID-19 affects patients with a history migraine. Here, we present the cases of 2 women with a history of migraine whose first symptom of COVID-19 was a severe persistent headache. PMID: 32521062 [PubMed - as supplied by publisher] (Source: Headache)
Source: Headache - June 10, 2020 Category: Neurology Authors: Singh J, Ali A Tags: Headache Source Type: research

Calcitonin Gene-Related Peptide Receptor Antagonists (Gepants) for the Acute Treatment of Nausea in Episodic Migraine: A Systematic Review and Meta-Analysis.
CONCLUSION: There is sufficient evidence to support the efficacy of gepants for the treatment of nausea in episodic migraine. Future research may focus on examining this efficacy in under-represented patient populations (males, older age groups) and in chronic migraine. PMID: 32515018 [PubMed - as supplied by publisher] (Source: Headache)
Source: Headache - June 9, 2020 Category: Neurology Authors: Chan TLH, Cowan RP, Woldeamanuel YW Tags: Headache Source Type: research

Evolution and Migraine.
PMID: 32510587 [PubMed - as supplied by publisher] (Source: Headache)
Source: Headache - June 8, 2020 Category: Neurology Authors: Robbins L, Tropp-Bluestone M Tags: Headache Source Type: research

A Real-World Analysis of Patient Characteristics, Treatment Patterns, and Level of Impairment in Patients With Migraine Who are Insufficient Responders vs Responders to Acute Treatment.
CONCLUSIONS: Clinical characteristics, treatment patterns, and health-related quality of life measures are statistically significantly different between insufficient responders and responders to acute treatment in patients with migraine. PMID: 32510611 [PubMed - as supplied by publisher] (Source: Headache)
Source: Headache - June 8, 2020 Category: Neurology Authors: Lombard L, Ye W, Nichols R, Jackson J, Cotton S, Joshi S Tags: Headache Source Type: research

Chronic Migraine With Apparent Loss of Response to Onabotulinum Toxin Type A Due to Local Nitroglycerin Treatment for an Anal Fissure: A Case Report.
We present a patient with chronic migraine with good response to onabotulinum toxin type A whose headaches worsened in clear temporal relationship to local treatment with glyceryl trinitrate for an anal fissure. Our case shows that the use, even at distance, of nitric oxide donors can be a precipitating factor for migraineurs and should be always inquired in chronic migraine patients. In addition, the presence of frequent headaches should always be ruled out before prescribing such medications. PMID: 32491189 [PubMed - as supplied by publisher] (Source: Headache)
Source: Headache - June 3, 2020 Category: Neurology Authors: Pérez-Pereda S, González-Quintanilla V, Madera J, Pascual J Tags: Headache Source Type: research

Impact of 24-Hour On-Call Shifts on Headache in Medical Residents: A Cohort Study.
osa S Abstract BACKGROUND: During 24-hour on-call shifts medical residents are exposed to diverse circumstances such as sleep deprivation and stress. OBJECTIVE: Our aim is to assess the effect of 24-hour on-call shifts on medical residents' headache-related disability. METHODS: The Migraine Disability Assessment Scale (MIDAS), the Headache Impact Test (HIT-6), the Pittsburgh Sleep Quality Index (PSQI), and the Hospital Anxiety and Depression Scale (HADS) questionnaires were administered to medical residents who had never performed on-call shifts at baseline and 6 months after beginning 24-hour on-call sh...
Source: Headache - June 3, 2020 Category: Neurology Authors: Navarro-Pérez MP, Suller-Marti A, Bellosta-Diago E, Roche-Bueno JC, Santos-Lasaosa S Tags: Headache Source Type: research

De Novo Visual Aura Onset in a Migraineur on Galcanezumab-Gnlm.
PMID: 32476127 [PubMed - as supplied by publisher] (Source: Headache)
Source: Headache - June 1, 2020 Category: Neurology Authors: Kearney E, Collins T, Sengupta S Tags: Headache Source Type: research

Responding to the Needs of Early Career Physicians and Fellows in Headache Medicine: Career Planning, Getting Involved, and Considerations in Building a Headache Center.
PMID: 32476142 [PubMed - as supplied by publisher] (Source: Headache)
Source: Headache - June 1, 2020 Category: Neurology Authors: Minen MT, Wells RE, Gautreaux JR, Szperka CL, Rayhill M, Orlova Y, Metzler A, Halpern A, Monteith T Tags: Headache Source Type: research

AHS Members' Choice Award.
PMID: 32474922 [PubMed - in process] (Source: Headache)
Source: Headache - June 1, 2020 Category: Neurology Authors: Roberts J Tags: Headache Source Type: research

Is it Useful to Do a Taxonomy of Complex Visual Symptoms in Migraine? A Comment on Coining the Pablo Picasso Syndrome.
ero V PMID: 32474923 [PubMed - in process] (Source: Headache)
Source: Headache - June 1, 2020 Category: Neurology Authors: Viganò A, Mancini V, Mastria G, Di Piero V Tags: Headache Source Type: research

Lasmiditan for the acute treatment of migraine.
PMID: 32474924 [PubMed - in process] (Source: Headache)
Source: Headache - June 1, 2020 Category: Neurology Authors: Tepper D Tags: Headache Source Type: research

A Conceptual Introduction to Regression.
PMID: 32474925 [PubMed - in process] (Source: Headache)
Source: Headache - June 1, 2020 Category: Neurology Authors: Turner DP, Deng H Tags: Headache Source Type: research

The Relationship Between Parental Care and Pain in Children With Headache: A Narrative Review.
DISCUSSION: Parents' attitudes and behaviors toward their child's headache have a strong relation with the severity of headache attacks. Mothers seem to have more influence than fathers on children's pain and emotional regulation. We suggest that the presence of caregiver-child transmission of maladaptive coping strategies, arising from difficulties expressing emotion, may lead to incorrect management of headache pain, further facilitating headache chronification. PMID: 32474926 [PubMed - in process] (Source: Headache)
Source: Headache - June 1, 2020 Category: Neurology Authors: Natalucci G, Faedda N, Baglioni V, Guidetti V Tags: Headache Source Type: research

Practical Professional Ethics in Headache Medicine.
PMID: 32472695 [PubMed - as supplied by publisher] (Source: Headache)
Source: Headache - May 30, 2020 Category: Neurology Authors: Levin M Tags: Headache Source Type: research

Lower Glucose Level Associated With Increased Risk for Post-Dural Puncture Headache.
CONCLUSIONS: Low glucose levels were inversely associated with risk for post-dural puncture headache. Patients with low serum glucose should be carefully monitored for headache after lumbar puncture. PMID: 32463126 [PubMed - as supplied by publisher] (Source: Headache)
Source: Headache - May 28, 2020 Category: Neurology Authors: Hwang J, Lim YH, Eun MY, Jeon JY, Ko PW, Kim SH, Kang K, Lee HW, Park JS Tags: Headache Source Type: research

Readability Analysis of Online Headache and Migraine Information.
CONCLUSION: Physician experts in headache and migraine should actively cooperate in planning informative material to establish what information patients need to know, how they should use it, and how readable that material actually is. Readability ought to be established before the final website publication. Plain language ought to be used and written messages should be supplemented with visual content such as simple drawings. We recommend the setting up of a new dynamic, modern, plain-talking, and efficient approach in communication aimed at catching the public's attention with its readability and thus satisfying a migrain...
Source: Headache - May 28, 2020 Category: Neurology Authors: Russo A, Lavorgna L, Silvestro M, Abbadessa G, Bisecco A, Trojsi F, Tessitore A, Tedeschi G, Bonavita S Tags: Headache Source Type: research

The Science Fiction of Medical Quackery: Ray Bradbury's "Skeleton".
The Science Fiction of Medical Quackery: Ray Bradbury's "Skeleton". Headache. 2020 May 27;: Authors: Smith JH, Stone J PMID: 32459002 [PubMed - as supplied by publisher] (Source: Headache)
Source: Headache - May 27, 2020 Category: Neurology Authors: Smith JH, Stone J Tags: Headache Source Type: research

The Stereotypical Image of a Person With Migraine According to Mass Media.
CONCLUSION: The demographics in terms of gender, race, and age reflect large population studies of migraine; however, we are concerned about the stereotypical depiction of "acute pain behavior" (ie, eye closed, hands on temples) on these images as this is inconsistent with the actual presentations of people with migraine in our clinical experience. This disparity may both derive from, and further contribute to, social stigmatization and lack of public and employer validation of migraine-related disability. We suggest that future efforts in migraine advocacy may focus on ensuring the portrayal in mass media of an ...
Source: Headache - May 27, 2020 Category: Neurology Authors: Gvantseladze K, Do TP, Hansen JM, Shapiro RE, Ashina M Tags: Headache Source Type: research

Moving the Needle - The Patient's Perspective.
PMID: 32459368 [PubMed - as supplied by publisher] (Source: Headache)
Source: Headache - May 27, 2020 Category: Neurology Authors: MacDonald K Tags: Headache Source Type: research

The Role of Diet and Nutrition in Migraine Triggers and Treatment: A Systematic Literature Review.
CONCLUSIONS: There is limited high-quality randomized controlled trial data on diet patterns or diet-related triggers. A few small randomized controlled trials have assessed diet interventions in preventing migraine attacks without strong results. Although many patients already reported avoiding personal diet-related triggers in their migraine management, high-quality research is needed to confirm the effect of diet in people with migraine. PMID: 32449944 [PubMed - as supplied by publisher] (Source: Headache)
Source: Headache - May 25, 2020 Category: Neurology Authors: Hindiyeh NA, Zhang N, Farrar M, Banerjee P, Lombard L, Aurora SK Tags: Headache Source Type: research

Effect of Fremanezumab Monthly and Quarterly Doses on Efficacy Responses.
CONCLUSIONS: Exposure-response evaluations showed that both monthly (225 mg) and quarterly (675 mg) fremanezumab dosing regimens were appropriate in achieving clinical benefit in adult patients with EM or CM. PMID: 32445498 [PubMed - as supplied by publisher] (Source: Headache)
Source: Headache - May 23, 2020 Category: Neurology Authors: Fiedler-Kelly J, Passarell J, Ludwig E, Levi M, Cohen-Barak O Tags: Headache Source Type: research

Dual Therapy With Anti-CGRP Monoclonal Antibodies and Botulinum Toxin for Migraine Prevention: Is There a Rationale?
CONCLUSION: There is currently only indirect preclinical evidence to support a rationale for dual therapy with anti-calcitonin gene-related peptide monoclonal antibodies and botulinum toxin type A for chronic migraine prevention. Rigorous studies evaluating clinical efficacy, safety, and cost-effectiveness are needed. PMID: 32437038 [PubMed - as supplied by publisher] (Source: Headache)
Source: Headache - May 21, 2020 Category: Neurology Authors: Pellesi L, Do TP, Ashina H, Ashina M, Burstein R Tags: Headache Source Type: research

Teaching Images in Headache: Is This Just a Post-Dural Puncture Headache? A Case Report.
PMID: 32420618 [PubMed - as supplied by publisher] (Source: Headache)
Source: Headache - May 18, 2020 Category: Neurology Authors: Chiang CC, VanderPluym JH, Starling AJ Tags: Headache Source Type: research

COVID-19 is a Real Headache!
n B Abstract After the emergence of a novel coronavirus named SARS-CoV-2, coronavirus disease 2019 (COVID-19) was initially characterized by fever, sore throat, cough and dyspnea, mainly manifestations of respiratory system. However, other manifestations such as headache, abdominal pain, diarrhea, loss of taste and smell were added to the clinical spectrum, during the course of the COVID-19 pandemic. The reports on the neurological findings are increasing rapidly and headache seems to be the leader on the symptom list. Headache was reported in 11-34% of the hospitalized COVID-19 patients, but clinical features of ...
Source: Headache - May 15, 2020 Category: Neurology Authors: Bolay H, Gül A, Baykan B Tags: Headache Source Type: research

Headaches During COVID-19: My Clinical Case and Review of the Literature.
CONCLUSIONS: Several headaches can appear during COVID-19 infection. All of them are headaches specified in the ICHD3, except 1 that occurs from the 7th day after the clinical onset. This headache is probably related to the cytokine storm that some patients suffer and it could be framed under the ICHD3 headache of Headache attributed to other non-infectious inflammatory intracranial disease. Although the reported prevalence of headaches as a symptom of COVID-19 infection is low, this experience shows that, very probably, it is underestimated. PMID: 32413158 [PubMed - as supplied by publisher] (Source: Headache)
Source: Headache - May 15, 2020 Category: Neurology Authors: Belvis R Tags: Headache Source Type: research

Could CGRP antagonists be helpful in the fight against COVID-19?
Abstract When treating migraine patients in the current era of Coronavirus Disease 2019 (COVID-19), many institutions have moved away from face-to-face procedures like onabotulinumtoxinA injections,1 sometimes transitioning to the newer CGRP antibodies for migraine prevention. However, despite our best efforts to mitigate viral transmission, many of our migraine patients may eventually be exposed to SARS-CoV2. While most patients will have mild to moderate symptoms, a subset will become severely ill, with possible complications including respiratory failure and acute respiratory distress syndrome (ARDS). Given the...
Source: Headache - May 9, 2020 Category: Neurology Authors: Robertson CE Tags: Headache Source Type: research

United States Patients' Perspective of Living With Migraine: Country-Specific Results From the Global "My Migraine Voice" Survey.
CONCLUSIONS: Migraine impacts individuals' activities of daily living, work-life, and financial status, especially individuals with high needs, namely those with 4 or more monthly migraine days and prior treatment failures. People with migraine are impaired during all migraine phases, experience fear of their next migraine attack and sleep difficulties, and pay substantial monthly out-of-pocket costs for migraine. Burden is even greater among those who have had 2 or more preventive treatment failures. Impacts of migraine extend beyond probands to caregivers who help people with migraine with daily tasks, employers who are ...
Source: Headache - May 5, 2020 Category: Neurology Authors: Gibbs SN, Shah S, Deshpande CG, Bensink ME, Broder MS, Dumas PK, Buse DC, Vo P, Schwedt TJ Tags: Headache Source Type: research