Estimating Bleeding Risk in Patients with Cancer-Associated Thrombosis: Evaluation of Existing Risk Scores and Development of a New Risk Score
CONCLUSION: Existing risk scores for bleeding perform poorly after CAT. Pragmatic classification based on cancer type provides marginally better estimates of clinically relevant bleeding risk. Further improvement may be achieved with "CAT-BLEED," but this requires external validation in practice-based settings and with other DOACs and its clinical usefulness is yet to be demonstrated.PMID:34544170 | DOI:10.1055/s-0041-1735251 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - September 20, 2021 Category: Hematology Authors: Maria A de Winter Jannick A N Dorresteijn Walter Ageno Cihan Ay Jan Beyer-Westendorf Michiel Coppens Frederikus A Klok Far ès Moustafa Nicoletta Riva Pedro C Ruiz Artacho Thomas Vanassche Mathilde Nijkeuter Source Type: research

Platelets Contribute to Disease Severity in COVID-19
CONCLUSIONS: COVID-19 platelet count, size, and maturity associate with increased critical illness and all-cause mortality. Profiling tissues and blood from COVID-19 patients revealed that SARS-CoV-2 virions enter megakaryocytes and platelets and associate with alterations to the platelet transcriptome and activation profile.PMID:34538015 | DOI:10.1111/jth.15534 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - September 19, 2021 Category: Hematology Authors: Tessa J Barrett Seda Bilaloglu Macintosh Cornwell Hannah M Burgess Vitor W Virginio Kamelia Drenkova Homam Ibrahim Eugene Yuriditsky Yin Aphinyanaphongs Mark Lifshitz Feng Xia Liang Julie Alejo Grace Smith Stefania Pittaluga Amy V Rapkiewicz Jun Wang Came Source Type: research

Use of Novel Antithrombotic Agents for COVID-19: Systemic Summary of Ongoing Randomized Controlled Trials
CONCLUSION: Some novel antithrombotic agents have pleiotropic anti-inflammatory and antiviral effects, which may help reduce the viral load or fibrosis, and improve oxygenation. Results from ongoing RCTs will elucidate their actual role in the management of patients with COVID-19.PMID:34538017 | DOI:10.1111/jth.15533 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - September 19, 2021 Category: Hematology Authors: Azita H Talasaz Parham Sadeghipour Maryam Aghakouchakzadeh Hessam Kakavand Hamid Ariannejad Jean M Connors Beverley J Hunt Jeffrey S Berger Benjamin W Van Tassell Saskia Middeldorp Gregory Piazza Jeffrey I Weitz Mary Cushman Gregory Y H Lip Samuel Z Goldh Source Type: research

Pathology of lung-specific thrombosis and inflammation in COVID-19
CONCLUSIONS: studying (ultra)structural features of the autopsy lung samples from patients with COVID-19 has provided evidence for a pathogenic link between inflammation and thrombosis. The major features in the lungs of COVID-19 patients comprised primary inflammatory thrombosis associated with diffuse alveolar damage. The lungs had pronounced circulatory changes with inflammation-dependent intravascular blood clotting, whereas heart, brain, and kidneys had predominantly degenerative changes that were distinct from the lung pathology.PMID:34538029 | DOI:10.1111/jth.15532 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - September 19, 2021 Category: Hematology Authors: Rafael R Khismatullin Anastasia A Ponomareva Chandrasekaran Nagaswami Rozalina A Ivaeva Kathleen T Montone John W Weisel Rustem I Litvinov Source Type: research

Platelets Contribute to Disease Severity in COVID-19
CONCLUSIONS: COVID-19 platelet count, size, and maturity associate with increased critical illness and all-cause mortality. Profiling tissues and blood from COVID-19 patients revealed that SARS-CoV-2 virions enter megakaryocytes and platelets and associate with alterations to the platelet transcriptome and activation profile.PMID:34538015 | DOI:10.1111/jth.15534 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - September 19, 2021 Category: Hematology Authors: Tessa J Barrett Seda Bilaloglu Macintosh Cornwell Hannah M Burgess Vitor W Virginio Kamelia Drenkova Homam Ibrahim Eugene Yuriditsky Yin Aphinyanaphongs Mark Lifshitz Feng Xia Liang Julie Alejo Grace Smith Stefania Pittaluga Amy V Rapkiewicz Jun Wang Came Source Type: research

Use of Novel Antithrombotic Agents for COVID-19: Systemic Summary of Ongoing Randomized Controlled Trials
CONCLUSION: Some novel antithrombotic agents have pleiotropic anti-inflammatory and antiviral effects, which may help reduce the viral load or fibrosis, and improve oxygenation. Results from ongoing RCTs will elucidate their actual role in the management of patients with COVID-19.PMID:34538017 | DOI:10.1111/jth.15533 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - September 19, 2021 Category: Hematology Authors: Azita H Talasaz Parham Sadeghipour Maryam Aghakouchakzadeh Hessam Kakavand Hamid Ariannejad Jean M Connors Beverley J Hunt Jeffrey S Berger Benjamin W Van Tassell Saskia Middeldorp Gregory Piazza Jeffrey I Weitz Mary Cushman Gregory Y H Lip Samuel Z Goldh Source Type: research

Pathology of lung-specific thrombosis and inflammation in COVID-19
CONCLUSIONS: studying (ultra)structural features of the autopsy lung samples from patients with COVID-19 has provided evidence for a pathogenic link between inflammation and thrombosis. The major features in the lungs of COVID-19 patients comprised primary inflammatory thrombosis associated with diffuse alveolar damage. The lungs had pronounced circulatory changes with inflammation-dependent intravascular blood clotting, whereas heart, brain, and kidneys had predominantly degenerative changes that were distinct from the lung pathology.PMID:34538029 | DOI:10.1111/jth.15532 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - September 19, 2021 Category: Hematology Authors: Rafael R Khismatullin Anastasia A Ponomareva Chandrasekaran Nagaswami Rozalina A Ivaeva Kathleen T Montone John W Weisel Rustem I Litvinov Source Type: research

Thrombosis in myeloproliferative neoplasms: Treatment outcomes of direct oral anticoagulants and vitamin K antagonists
CONCLUSION: Our data did not demonstrate a significant difference in recurrent TEs or bleeding events in patients with MPN-associated thrombosis anticoagulated with either DOACs or VKAs.PMID:34532628 | PMC:PMC8440942 | DOI:10.1002/rth2.12574 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - September 17, 2021 Category: Hematology Authors: Kateryna Fedorov Swati Goel Margarita Kushnir Henny H Billett Source Type: research

Severe COVID-19 is associated with endothelial activation and abnormal glycosylation of von Willebrand factor in patients undergoing hemodialysis
CONCLUSIONS: Severe COVID-19 in patients undergoing hemodialysis is associated with both acute and sustained activation of the endothelium, leading to alteration of the VWF/ADAMTS-13 axis. Lower VWF sialic acid content represents altered VWF processing and further confirms the disturbance caused to the endothelium in COVID-19.PMID:34532629 | PMC:PMC8435526 | DOI:10.1002/rth2.12582 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - September 17, 2021 Category: Hematology Authors: Golzar Mobayen Amrita Dhutia Candice Clarke Maria Prendecki Stephen McAdoo Renos Keniyopoullos Talat Malik Michael Laffan Michelle Willicombe Thomas McKinnon Source Type: research

The use of qualitative methods in venous thromboembolism research
CONCLUSION: A qualitative research approach can reveal individual experiences and psychosocial impact in patients diagnosed with VTE, which allow the researchers to better comprehend the complexity of this phenomenon and its impact in health care.PMID:34532630 | PMC:PMC8435525 | DOI:10.1002/rth2.12593 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - September 17, 2021 Category: Hematology Authors: Jackeline Hernandez-Nino Mary Thomas Andreia B Alexander Mary A Ott Jeffrey A Kline Source Type: research

Quantitative 3D microscopy highlights altered von Willebrand factor α-granule storage in patients with von Willebrand disease with distinct pathogenic mechanisms
CONCLUSIONS: Our findings highlight the utility of quantitative imaging approaches in assessing platelet granule content, which may help to better understand VWF storage in α-granules and to gain new insights in the etiology of VWD.PMID:34532631 | PMC:PMC8440947 | DOI:10.1002/rth2.12595 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - September 17, 2021 Category: Hematology Authors: Maurice Swinkels Ferdows Atiq Petra E B ürgisser Johan A Slotman Adriaan B Houtsmuller Cilia de Heus Judith Klumperman Frank W G Leebeek Jan Voorberg Arend Jan Gerard Jansen Ruben Bierings Source Type: research

Vaccine-induced immune thrombotic thrombocytopenia presenting with normal platelet count
We report on three patients who presented to our institute with this syndrome. Noteworthy in our presentations are two patients who presented for medical assessment of thrombotic symptoms with a normal platelet count, one preceding and one following a period of thrombocytopenia. Prompt diagnosis of VITT is critical to prevent rapid patient decline. We provide herein a new diagnostic algorithm that we believe will help optimally capture case presentations of VITT. These cases broaden and refine our understanding of the disease process and highlight to practitioners that VITT cannot be adequately ruled out by thrombocytopeni...
Source: Thrombosis and Haemostasis - September 17, 2021 Category: Hematology Authors: David Page Nancy Zhu Daniel Sawler Hao Wei Sun Elona Turley Menaka Pai Cynthia Wu Source Type: research

The prognostic value of respiratory symptoms and performance status in ambulatory cancer patients and unsuspected pulmonary embolism; analysis of an international, prospective, observational cohort study
CONCLUSION: In ACPs with UPE, ECOG performance status logged contemporaneously to the UPE diagnosis and respiratory symptoms prior to UPE diagnosis can stratify mortality risk. When applied to the HULL-CPR these risk predictors confirmed the risk stratification clusters of low-intermediate and high-risk for proximate mortality as seen in the original derivation cohort.PMID:34532927 | DOI:10.1111/jth.15489 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - September 17, 2021 Category: Hematology Authors: Anthony Maraveyas No émie Kraaijpoel George Bozas Chao Huang Isabelle Mah é Laurent Bertoletti Annemarieke Bartels-Rutten Jan Beyer-Westendorf Joel Constans Diana Iosub Francis Couturaud Andres J Mu ñoz Mercedes Biosca Teresa Lerede Nick van Es Marcell Source Type: research

Kallikrein augments the anticoagulant function of the protein C system in thrombin generation
CONCLUSIONS: Our results suggest that kallikrein plays a role in the regulation of the anticoagulant protein C pathway in TG, which may provide a novel mechanism for the previously observed association between the KLKB1 gene and venous thrombosis.PMID:34532976 | DOI:10.1111/jth.15530 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - September 17, 2021 Category: Hematology Authors: Jun Wan Nadira Vadaq Joke Konings Martin Jaeger Vinod Kumar Bas de Laat Leo Joosten Mihai G Netea Andre J van der Ven Philip G de Groot Quirijn de Mast Mark Roest Source Type: research

Extended Anticoagulant Treatment with Full- or Reduced-Dose Apixaban in Patients with Cancer-Associated Venous Thromboembolism: the API-CAT Study
Thromb Haemost. 2021 Sep 17. doi: 10.1055/a-1647-9896. Online ahead of print.ABSTRACTCancer-associated thrombosis (CAT) is associated with a high risk of recurrent venous thromboembolic events (VTE) that require extended anticoagulation in patients with active cancer, putting them at risk of bleeding.The aim of the API-CAT study (NCT03692065) is to assess whether a reduced-dose regimen of apixaban (2.5 mg twice daily [bid]) is non-inferior to a full-dose regimen of apixaban (5 mg bid) for the prevention of recurrent VTE in patients with active cancer who have completed ≥6 months of anticoagulant therapy for a documented...
Source: Thrombosis and Haemostasis - September 17, 2021 Category: Hematology Authors: Isabelle Mah é Giancarlo Agnelli Cihan Ay Aristotle Bamias Cecilia Becattini Marc Carrier C éline Chapelle Alexander T Cohen Philippe Girard Menno V Huisman Erik Klok Juan Jos é López-Núñez Anthony Maraveyas Didier Mayeur Olivier Mir Manuel Monreal Source Type: research

Why Fibrin Biomechanical Properties Matter for Haemostasis and Thrombosis
J Thromb Haemost. 2021 Sep 16. doi: 10.1111/jth.15531. Online ahead of print.ABSTRACTPolymeric fibrin displays unique structural and biomechanical properties that contribute to its essential role of generating blood clots that stem bleeds. The aim of this review is to discuss how the fibrin clot is formed, how protofibrils make up individual fibrin fibres, what the relationship is between the molecular structure and fibrin biomechanical properties, and how fibrin biomechanical properties relate to the risk of thromboembolic disease. Fibrin polymerisation is driven by different types of bonds, including knob-hole interactio...
Source: Thrombosis and Haemostasis - September 16, 2021 Category: Hematology Authors: T ímea Feller Simon D A Connell Robert A S Ari ёns Source Type: research

Desialylation of O-glycans activates von Willebrand factor by destabilizing its autoinhibitory module
CONCLUSIONS: Desialylation of O-glycans around A1 increases its activity by destabilizing the AIM.PMID:34529349 | DOI:10.1111/jth.15528 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - September 16, 2021 Category: Hematology Authors: Kayleigh M Voos Wenpeng Cao Nicholas A Arce Emily R Legan Yingchun Wang Asif Shajahan Parastoo Azadi Pete Lollar X Frank Zhang Renhao Li Source Type: research

Extended-Duration Low-intensity Apixaban to Prevent Recurrence in Patients with Provoked Venous Thromboembolism: Design of the HI-PRO Trial
Thromb Haemost. 2021 Sep 16. doi: 10.1055/a-1646-2244. Online ahead of print.ABSTRACTPatients with acute venous thromboembolism (VTE) in the setting of transient provoking factors are typically treated with short-term anticoagulation. However, the risk of recurrence may be increased in the presence of enduring risk factors. In such patients, the optimal duration of treatment remains uncertain. HI-PRO is a single-center, double-blind randomized trial. Patients with deep vein thrombosis (DVT) or pulmonary embolism (PE) following a major provoking factor, including major surgery or major trauma, who completed at least 3 month...
Source: Thrombosis and Haemostasis - September 16, 2021 Category: Hematology Authors: Behnood Bikdeli Heather Hogan Ruth Morrison John Fanikos Umberto Campia Briana Barns Mariana Pfeferman Julia Snyder Candrika Khairani Samuel Z Goldhaber Gregory Piazza Source Type: research

Apixaban and Dalteparin for the Treatment of Venous Thromboembolism in Patients with Different Sites of Cancer
In conclusion, recurrences appear to be more common in patients with gastrointestinal and gynecological cancer and major bleedings in patients with genitourinary and gastrointestinal cancer. Oral apixaban is a valid oral alternative to subcutaneous dalteparin for the treatment of a large spectrum of patients with cancer-associated VTE.PMID:34530482 | DOI:10.1055/s-0041-1735194 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - September 16, 2021 Category: Hematology Authors: Giancarlo Agnelli Andr és Muñoz Laura Franco Isabelle Mah é Benjamin Brenner Jean M Connors Gualberto Gussoni Eva N Hamulyak Catherine Lambert Maria Rosales Suero Rupert Bauersachs Adam Torbicki Cecilia Becattini Source Type: research

Thrombin generation assays are versatile tools in blood coagulation analysis: a review of technical features, and applications from research to laboratory routine
J Thromb Haemost. 2021 Sep 15. doi: 10.1111/jth.15529. Online ahead of print.ABSTRACTThrombin is the pivotal enzyme in the biochemistry of secondary haemostasis crucial to maintaining homeostasis of haemostasis. In contrast to routine coagulation tests (PT or aPTT) or procoagulant or anticoagulant factor assays (e.g. fibrinogen, factor VIII, antithrombin or protein C), the thrombin generation assay (TGA), also named thrombin generation test (TGT) is a so-called "global assay" that provides a picture of the haemostasis balance though a continuous and simultaneous measurement of thrombin formation and inhibition. F...
Source: Thrombosis and Haemostasis - September 15, 2021 Category: Hematology Authors: Fran çois Depasse Nikolaus B Binder Julia Mueller Thomas Wissel Stephan Schwers Matthias Germer Bj örn Hermes Peter L Turecek Source Type: research

Thrombin generation assays are versatile tools in blood coagulation analysis: a review of technical features, and applications from research to laboratory routine
J Thromb Haemost. 2021 Sep 15. doi: 10.1111/jth.15529. Online ahead of print.ABSTRACTThrombin is the pivotal enzyme in the biochemistry of secondary haemostasis crucial to maintaining homeostasis of haemostasis. In contrast to routine coagulation tests (PT or aPTT) or procoagulant or anticoagulant factor assays (e.g. fibrinogen, factor VIII, antithrombin or protein C), the thrombin generation assay (TGA), also named thrombin generation test (TGT) is a so-called "global assay" that provides a picture of the haemostasis balance though a continuous and simultaneous measurement of thrombin formation and inhibition. F...
Source: Thrombosis and Haemostasis - September 15, 2021 Category: Hematology Authors: Fran çois Depasse Nikolaus B Binder Julia Mueller Thomas Wissel Stephan Schwers Matthias Germer Bj örn Hermes Peter L Turecek Source Type: research

Thrombin generation assays are versatile tools in blood coagulation analysis: a review of technical features, and applications from research to laboratory routine
J Thromb Haemost. 2021 Sep 15. doi: 10.1111/jth.15529. Online ahead of print.ABSTRACTThrombin is the pivotal enzyme in the biochemistry of secondary haemostasis crucial to maintaining homeostasis of haemostasis. In contrast to routine coagulation tests (PT or aPTT) or procoagulant or anticoagulant factor assays (e.g. fibrinogen, factor VIII, antithrombin or protein C), the thrombin generation assay (TGA), also named thrombin generation test (TGT) is a so-called "global assay" that provides a picture of the haemostasis balance though a continuous and simultaneous measurement of thrombin formation and inhibition. F...
Source: Thrombosis and Haemostasis - September 15, 2021 Category: Hematology Authors: Fran çois Depasse Nikolaus B Binder Julia Mueller Thomas Wissel Stephan Schwers Matthias Germer Bj örn Hermes Peter L Turecek Source Type: research

Thrombin generation assays are versatile tools in blood coagulation analysis: a review of technical features, and applications from research to laboratory routine
J Thromb Haemost. 2021 Sep 15. doi: 10.1111/jth.15529. Online ahead of print.ABSTRACTThrombin is the pivotal enzyme in the biochemistry of secondary haemostasis crucial to maintaining homeostasis of haemostasis. In contrast to routine coagulation tests (PT or aPTT) or procoagulant or anticoagulant factor assays (e.g. fibrinogen, factor VIII, antithrombin or protein C), the thrombin generation assay (TGA), also named thrombin generation test (TGT) is a so-called "global assay" that provides a picture of the haemostasis balance though a continuous and simultaneous measurement of thrombin formation and inhibition. F...
Source: Thrombosis and Haemostasis - September 15, 2021 Category: Hematology Authors: Fran çois Depasse Nikolaus B Binder Julia Mueller Thomas Wissel Stephan Schwers Matthias Germer Bj örn Hermes Peter L Turecek Source Type: research

New Inhibitors in the Ageing Population: A retrospective, observational, cohort study of new inhibitors in older people with haemophilia
CONCLUSION: Our data do not identify a second peak of inhibitor development in older patients with haemophilia. Prophylaxis may be beneficial in older patients with severe, and possibly moderate HA, to retain a tolerant state at higher age.PMID:34507368 | DOI:10.1055/a-1642-4067 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - September 10, 2021 Category: Hematology Authors: Jan Astermark Cihan Ay Manuela Carvalho Roseline D'Oiron Philippe De Moerloose Gerard Dolan Pierre Fontana Cedric Hermans P ål Andre Holme Olga Katsarou Gili Kenet Robert Klamroth Maria Elisa Elisa Mancuso Natascha Marquardt Ramiro N úñez Ingrid Pabing Source Type: research

Platelet activation and reactivity in a large cohort of patients with Gaucher disease
CONCLUSION: Flow cytometry enables the study of platelet function in thrombocytopenic GD patients. A platelet degranulation defect, but not αIIbβ3 integrin activation defect, is associated with clinical bleeding. In vivo increased CD63 expression may be related to GD-related inflammation.PMID:34507369 | DOI:10.1055/a-1642-4206 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - September 10, 2021 Category: Hematology Authors: Shoshana Revel-Vilk Mira Naamad Dafna Frydman Michael R Freund Tama Dinur Majdolen Istaiti Michal Becker-Cohen Roni Falk Eti Broide Alan D Michelson Andrew L Frelinger Iii Ari Zimran Source Type: research

New Inhibitors in the Ageing Population: A retrospective, observational, cohort study of new inhibitors in older people with haemophilia
CONCLUSION: Our data do not identify a second peak of inhibitor development in older patients with haemophilia. Prophylaxis may be beneficial in older patients with severe, and possibly moderate HA, to retain a tolerant state at higher age.PMID:34507368 | DOI:10.1055/a-1642-4067 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - September 10, 2021 Category: Hematology Authors: Jan Astermark Cihan Ay Manuela Carvalho Roseline D'Oiron Philippe De Moerloose Gerard Dolan Pierre Fontana Cedric Hermans P ål Andre Holme Olga Katsarou Gili Kenet Robert Klamroth Maria Elisa Elisa Mancuso Natascha Marquardt Ramiro N úñez Ingrid Pabing Source Type: research

Platelet activation and reactivity in a large cohort of patients with Gaucher disease
CONCLUSION: Flow cytometry enables the study of platelet function in thrombocytopenic GD patients. A platelet degranulation defect, but not αIIbβ3 integrin activation defect, is associated with clinical bleeding. In vivo increased CD63 expression may be related to GD-related inflammation.PMID:34507369 | DOI:10.1055/a-1642-4206 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - September 10, 2021 Category: Hematology Authors: Shoshana Revel-Vilk Mira Naamad Dafna Frydman Michael R Freund Tama Dinur Majdolen Istaiti Michal Becker-Cohen Roni Falk Eti Broide Alan D Michelson Andrew L Frelinger Iii Ari Zimran Source Type: research

New Inhibitors in the Ageing Population: A retrospective, observational, cohort study of new inhibitors in older people with haemophilia
CONCLUSION: Our data do not identify a second peak of inhibitor development in older patients with haemophilia. Prophylaxis may be beneficial in older patients with severe, and possibly moderate HA, to retain a tolerant state at higher age.PMID:34507368 | DOI:10.1055/a-1642-4067 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - September 10, 2021 Category: Hematology Authors: Jan Astermark Cihan Ay Manuela Carvalho Roseline D'Oiron Philippe De Moerloose Gerard Dolan Pierre Fontana Cedric Hermans P ål Andre Holme Olga Katsarou Gili Kenet Robert Klamroth Maria Elisa Elisa Mancuso Natascha Marquardt Ramiro N úñez Ingrid Pabing Source Type: research

Platelet activation and reactivity in a large cohort of patients with Gaucher disease
CONCLUSION: Flow cytometry enables the study of platelet function in thrombocytopenic GD patients. A platelet degranulation defect, but not αIIbβ3 integrin activation defect, is associated with clinical bleeding. In vivo increased CD63 expression may be related to GD-related inflammation.PMID:34507369 | DOI:10.1055/a-1642-4206 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - September 10, 2021 Category: Hematology Authors: Shoshana Revel-Vilk Mira Naamad Dafna Frydman Michael R Freund Tama Dinur Majdolen Istaiti Michal Becker-Cohen Roni Falk Eti Broide Alan D Michelson Andrew L Frelinger Iii Ari Zimran Source Type: research

New Inhibitors in the Ageing Population: A retrospective, observational, cohort study of new inhibitors in older people with haemophilia
CONCLUSION: Our data do not identify a second peak of inhibitor development in older patients with haemophilia. Prophylaxis may be beneficial in older patients with severe, and possibly moderate HA, to retain a tolerant state at higher age.PMID:34507368 | DOI:10.1055/a-1642-4067 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - September 10, 2021 Category: Hematology Authors: Jan Astermark Cihan Ay Manuela Carvalho Roseline D'Oiron Philippe De Moerloose Gerard Dolan Pierre Fontana Cedric Hermans P ål Andre Holme Olga Katsarou Gili Kenet Robert Klamroth Maria Elisa Elisa Mancuso Natascha Marquardt Ramiro N úñez Ingrid Pabing Source Type: research

Platelet activation and reactivity in a large cohort of patients with Gaucher disease
CONCLUSION: Flow cytometry enables the study of platelet function in thrombocytopenic GD patients. A platelet degranulation defect, but not αIIbβ3 integrin activation defect, is associated with clinical bleeding. In vivo increased CD63 expression may be related to GD-related inflammation.PMID:34507369 | DOI:10.1055/a-1642-4206 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - September 10, 2021 Category: Hematology Authors: Shoshana Revel-Vilk Mira Naamad Dafna Frydman Michael R Freund Tama Dinur Majdolen Istaiti Michal Becker-Cohen Roni Falk Eti Broide Alan D Michelson Andrew L Frelinger Iii Ari Zimran Source Type: research

Socioeconomic status and risk of incident venous thromboembolism
CONCLUSION: High levels of both individual SES indicators and a composite SES score were associated with decreased VTE risk.PMID:34498381 | DOI:10.1111/jth.15523 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - September 9, 2021 Category: Hematology Authors: Helle J ørgensen Erzs ébet Horváth-Puhó Kristina Laugesen Sigrid Braekkan John-Bjarne Hansen Henrik Toft S ørensen Source Type: research

Socioeconomic status and risk of incident venous thromboembolism
CONCLUSION: High levels of both individual SES indicators and a composite SES score were associated with decreased VTE risk.PMID:34498381 | DOI:10.1111/jth.15523 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - September 9, 2021 Category: Hematology Authors: Helle J ørgensen Erzs ébet Horváth-Puhó Kristina Laugesen Sigrid Braekkan John-Bjarne Hansen Henrik Toft S ørensen Source Type: research

Assessing the clinical probability of pulmonary embolism during pregnancy: THE Pregnancy-Adapted Geneva (PAG) score
CONCLUSION: In pregnant women with suspected PE, the PAG score shows a high discriminative power to identify patients at low, intermediate or high PTP. It has the strength of being a fully objective decision rule, is clinically relevant, easy to compute, and should now be tested in a prospective outcome study.PMID:34496121 | DOI:10.1111/jth.15521 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - September 8, 2021 Category: Hematology Authors: Helia Robert-Ebadi Antoine Elias Olivier Sanchez Emmanuelle Le Moigne Jeannot Schmidt Catherine Le Gall Drahomir Aujesky Pierre-Marie Roy Thomas Moumneh C éline Chauleur Frederic Rouyer Gr égoire Le Gal Marc Righini Source Type: research

Assessing the clinical probability of pulmonary embolism during pregnancy: THE Pregnancy-Adapted Geneva (PAG) score
CONCLUSION: In pregnant women with suspected PE, the PAG score shows a high discriminative power to identify patients at low, intermediate or high PTP. It has the strength of being a fully objective decision rule, is clinically relevant, easy to compute, and should now be tested in a prospective outcome study.PMID:34496121 | DOI:10.1111/jth.15521 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - September 8, 2021 Category: Hematology Authors: Helia Robert-Ebadi Antoine Elias Olivier Sanchez Emmanuelle Le Moigne Jeannot Schmidt Catherine Le Gall Drahomir Aujesky Pierre-Marie Roy Thomas Moumneh C éline Chauleur Frederic Rouyer Gr égoire Le Gal Marc Righini Source Type: research

Overall survival with warfarin versus low-molecular-weight heparin in cancer-associated thrombosis
J Thromb Haemost. 2021 Sep 7. doi: 10.1111/jth.15519. Online ahead of print.ABSTRACTBACKGROUND: When compared with warfarin, low-molecular-weight heparin (LMWH) reduces the incidence of recurrent venous thromboembolism (VTE) in cancer. However, a survival benefit of LMWH over warfarin for the treatment of cancer-associated VTE has not been established.METHODS: Using the Surveillance, Epidemiology and End Results (SEER) and Medicare linked database from 2007 through 2016, we identified Medicare beneficiaries (aged ≥66 years) who were: (1) diagnosed with primary gastric, colorectal, pancreatic, lung, ovarian, or brain can...
Source: Thrombosis and Haemostasis - September 7, 2021 Category: Hematology Authors: Thita Chiasakul Robert Redd Rushad Patell Adeel M Khan Ellen P McCarthy Donna Neuberg Jeffrey I Zwicker Source Type: research

Deterioration of vaccine-induced immune thrombotic thrombocytopenia treated by heparin and platelet transfusion: Insight from functional cytometry and serotonin release assay
We report a case of a 62-year-old man who developed cerebral venous sinus thrombosis with subarachnoid hemorrhage and concomitant thrombocytopenia, which occurred 13 days after ChAdOx1 nCov-19 injection. The patient died in the intensive care unit after heparin infusion and platelet transfusion. The key clinical purpose of this case report is to better understand how to confirm vaccine-induced immune thrombotic thrombocytopenia (VITT). VITT diagnosis was made using 14C-serotonin release and flow cytometry evaluating activation and platelet microvesicles on washed platelets. Four control patients were examined: a patient wi...
Source: Thrombosis and Haemostasis - September 6, 2021 Category: Hematology Authors: Alice B érezné David Bougon Florence Blanc-Jouvan Nicolas Gendron Cecile Janssen Michel Muller S ébastien Bertil Florence Desvard Isabelle Presot Benjamin Terrier Richard Chocron Olivier Sanchez Dominique Helley David M Smadja Source Type: research

The intersection of vector biology, gene therapy, and hemophilia
Res Pract Thromb Haemost. 2021 Sep 1;5(6):e12586. doi: 10.1002/rth2.12586. eCollection 2021 Aug.ABSTRACTGene therapy is at the forefront of the drive to bring the potential of cure to patients with genetic diseases. Multiple mechanisms of effective and efficient gene therapy delivery (eg, lentiviral, adeno-associated) for transgene expression as well as gene editing have been explored to improve vector and construct attributes and achieve therapeutic success. Recent clinical research has focused on recombinant adeno-associated viral (rAAV) vectors as a preferred method owing to their naturally occurring vector biology char...
Source: Thrombosis and Haemostasis - September 6, 2021 Category: Hematology Authors: Leszek Lisowski Janice M Staber J Fraser Wright Leonard A Valentino Source Type: research

Influence of Body Mass Index on Clinical Outcomes in Venous Thromboembolism: Insights from GARFIELD-VTE
J Thromb Haemost. 2021 Sep 6. doi: 10.1111/jth.15520. Online ahead of print.ABSTRACTBACKGROUND: There is limited information on the influence of body mass index (BMI) on clinical outcomes in patients with venous thromboembolism (VTE).OBJECTIVES: Investigate the influence of BMI on baseline characteristics, treatment patterns, and 24-month outcomes in VTE patients.METHODS: GARFIELD-VTE is a prospective, non-interventional study of 10,869 patients with objectively confirmed VTE. Patients were grouped according to BMI:
Source: Thrombosis and Haemostasis - September 6, 2021 Category: Hematology Authors: Jeffrey I Weitz Alfredo E Farjat Walter Ageno Alexander Gg Turpie Sylvia Haas Shinya Goto Samuel Z Goldhaber Pantep Angchaisuksiri Harry Gibbs Peter MacCallum Marc Carrier Gloria Kayani Sebastian Schellong Henri Bounameaux Lorenzo G Mantovani Paolo Prando Source Type: research

Mild COVID-19 and Impaired Blood Cell-Endothelial Crosstalk: Considering Long-Term Use of Antithrombotics?
CONCLUSION: These observational and descriptive data suggest that persistent viral cell injury may cause blood vessel damage; their increased permeability resulted in tissue edema, inflammation, platelet activation, and augmented thrombosis. There is a residual blood cell damage following the acute phase in some COVID-19 survivors. Controlled outcome-driven trials are urgently needed for exploring optimal use of long-term antithrombotics and vascular protection strategies even after mild COVID-19.PMID:34482535 | DOI:10.1055/a-1551-9911 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - September 5, 2021 Category: Hematology Authors: Arthur Melkumyants Ludmila Buryachkovskaya Nikita Lomakin Olga Antonova Victor Serebruany Source Type: research

Integrated Care for Stroke Management: Easy as ABC
Thromb Haemost. 2021 Sep 2. doi: 10.1055/a-1632-1777. Online ahead of print.ABSTRACTNo Abstract.PMID:34474499 | DOI:10.1055/a-1632-1777 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - September 2, 2021 Category: Hematology Authors: Gregory Yh Lip George Ntaios Source Type: research

Vaccine-induced immune thrombotic thrombocytopenia following AstraZeneca (ChAdOx1 nCOV19) vaccine-A case report
We present the first reported case of VITT at our institution and in Oman. This case highlights the potentially life-threatening complication associated with ChAdOx1 nCov-19 vaccine, clinical presentation, diagnostic approach, and treatment.PMID:34466769 | PMC:PMC8385181 | DOI:10.1002/rth2.12578 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - September 1, 2021 Category: Hematology Authors: Bader Al Rawahi Hashem BaTaher Zoheb Jaffer Aya Al-Balushi Asma Al-Mazrouqi Noof Al-Balushi Source Type: research

Response to rituximab in children and adults with immune thrombocytopenia (ITP)
CONCLUSIONS: Pre-rituximab immunologic evaluation varied significantly between adults and children, which could represent institution-specific practice patterns or a more general practice difference. If the latter, underlying immunodeficiency in adults with ITP may be underrecognized. Standardized guidance for pre-rituximab immunologic evaluation is needed.PMID:34466770 | PMC:PMC8385184 | DOI:10.1002/rth2.12587 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - September 1, 2021 Category: Hematology Authors: Emily M Harris Kirsty Hillier Hanny Al-Samkari Laura Berbert Rachael F Grace Source Type: research

Corticosteroid overuse in adults with immune thrombocytopenia: Cause for concern
Res Pract Thromb Haemost. 2021 Aug 25;5(6):e12592. doi: 10.1002/rth2.12592. eCollection 2021 Aug.ABSTRACTCorticosteroids remain a crucial component of first-line therapy for immune thrombocytopenia (ITP) due to low cost, high initial response rates, and acceptable short-term tolerability. However, extended and recurrent use of corticosteroids is associated with substantial toxicity. Survey studies indicate that>95% of patients with ITP treated with corticosteroids report adverse effects, more than one-third of whom require reduction or discontinuation of treatment. In light of the heavy treatment burden of prolonged cor...
Source: Thrombosis and Haemostasis - September 1, 2021 Category: Hematology Authors: Adam Cuker Howard A Liebman Source Type: research

Single or triple positivity for antiphospholipid antibodies in "carriers" or symptomatic patients: untangling the knot
CONCLUSION: This study shows that the thrombotic risk does not necessarily increase with the number of positive tests and raises the question of the therapeutic management of single aCL positive patients.PMID:34469630 | DOI:10.1111/jth.15518 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - September 1, 2021 Category: Hematology Authors: Daniel Bertin Laurence Camoin-Jau V éronique Veit No émie Resseguier Mathilde Lambert Pauline Buffet Delmas Xavier Heim Jean-Louis M ège Pierre-Emmanuel Morange Nathalie Bardin Source Type: research

Pseudohomozygous dysfibrinogenemia
This report addresses the key clinical question of whether genetic analysis enables clinically useful subclassification of patients with HD. We report a new case and identify a further eight previously documented cases that have the laboratory features of HD but biallelic inheritance of quantitative and qualitative fibrinogen gene variants. The cases displayed both bleeding and thrombosis and sometimes had undetectable fibrinogen activity. In all cases, the predicted effect of the coinherited variants is reduced levels of circulating fibrinogen that is all dysfunctional. We propose the term pseudohomozygous dysfibrinogenem...
Source: Thrombosis and Haemostasis - August 30, 2021 Category: Hematology Authors: Rachel C Peck Lucy Fitzgibbon Christopher Reilly-Stitt Christopher Doherty Emma Phillips Andrew D Mumford Source Type: research

Pseudohomozygous dysfibrinogenemia
This report addresses the key clinical question of whether genetic analysis enables clinically useful subclassification of patients with HD. We report a new case and identify a further eight previously documented cases that have the laboratory features of HD but biallelic inheritance of quantitative and qualitative fibrinogen gene variants. The cases displayed both bleeding and thrombosis and sometimes had undetectable fibrinogen activity. In all cases, the predicted effect of the coinherited variants is reduced levels of circulating fibrinogen that is all dysfunctional. We propose the term pseudohomozygous dysfibrinogenem...
Source: Thrombosis and Haemostasis - August 30, 2021 Category: Hematology Authors: Rachel C Peck Lucy Fitzgibbon Christopher Reilly-Stitt Christopher Doherty Emma Phillips Andrew D Mumford Source Type: research

Association of Pre-Hospital Antiplatelet Therapy with Survival in Patients Hospitalized with COVID-19: A Propensity Score-Matched Analysis
J Thromb Haemost. 2021 Aug 29. doi: 10.1111/jth.15517. Online ahead of print.ABSTRACTPURPOSE: Coronavirus disease-2019 (COVID-19) is associated with hypercoagulability and increased thrombotic risk. The impact of pre-hospital antiplatelet therapy on in-hospital mortality is uncertain.METHODS: This was an observational cohort study of 34,675 patients ≥50 years old from 90 health systems in the United States. Patients were hospitalized with laboratory confirmed COVID-19 between February 2020 and September 2020. For all patients, the propensity to receive pre-hospital antiplatelet therapy was calculated using demographics ...
Source: Thrombosis and Haemostasis - August 29, 2021 Category: Hematology Authors: Jonathan H Chow Ying Yin David P Yamane Danielle Davison Ryan Keneally Katrina Hawkins Gage Parr Mustafa Al-Mashat Jeffery S Berger Reamer L Bushardt Michael A Mazzeffi Stuart J Nelson Source Type: research

Guidance on the Critical Shortage of Sodium Citrate Coagulation Tubes for Hemostasis Testing
J Thromb Haemost. 2021 Aug 28. doi: 10.1111/jth.15514. Online ahead of print.ABSTRACTRecent manufacturing problems and increased utilization has created a shortage of 3.2% sodium citrate blood collection tubes used for coagulation testing, causing stakeholders such as hospitals, clinics and laboratories, to find suitable alternatives. Considerations for in-house citrate blood collection tube preparations or purchasing commercial products from unknown manufacturing sources is of a particular concern to laboratories that perform coagulation testing. It is well recognized that variability exists between citrate blood collecti...
Source: Thrombosis and Haemostasis - August 29, 2021 Category: Hematology Authors: Robert C Gosselin Annette Bowyer Emmanuel J Favaloro Jill M Johnsen Giuseppe Lippi Richard A Marlar Keith Neeves Marian A Rollins-Raval Source Type: research

Predictive significance of anti-FVIII immunoglobulin patterns on bleeding phenotype and outcomes in acquired hemophilia A (AHA): Results from the Quebec Reference Center for Inhibitors (QCRI)
CONCLUSION: The Ig pattern of AHA patients at diagnosis is widely heterogeneous and is at least partially associated with some underlying conditions. Our data supports the differential predictive significance for IgG1, IgG4 and IgM on bleeding severity and suggests that the early determination of Ig profile may help to identify AHA patients at higher risk of poorer outcomes.PMID:34455699 | DOI:10.1111/jth.15515 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - August 29, 2021 Category: Hematology Authors: Arnaud Bonnefoy Cl émence Merlen Evemie Dub é Hadrien Claus-Desbonnet Georges-Etienne Rivard Jean St-Louis Source Type: research