A human monoclonal antibody against the distal carboxyl terminus of ADAMTS13 modulates its susceptibility to an inhibitor in thrombotic thrombocytopenic purpura
J Thromb Haemost. 2021 Apr 9. doi: 10.1111/jth.15332. Online ahead of print.ABSTRACTBACKGROUND: Immune thrombotic thrombocytopenic purpura (iTTP) is a potentially fatal thrombotic microangiopathy, resulting from a severe deficiency of plasma ADAMTS13 activity. Immunoglobulin (Ig) G-type autoantibodies are primarily responsible for the inhibition of plasma ADAMTS13 activity. However, the mechanism underlying autoantibody-mediated inhibition is not fully understood.OBJECTIVE: The purpose of the present study is to determine the role of IgG autoantibodies against various carboxyl-terminal domains of ADAMTS13 in regulating ADA...
Source: Thrombosis and Haemostasis - April 9, 2021 Category: Hematology Authors: Konstantine Halkidis Don L Siegel X Long Zheng Source Type: research

Pregnancy-Associated Pelvic Vein thrombosis: Insights from a Multicentre Case Series
CONCLUSION: Symptomatic PVT has significant clinical implications with prolonged fever and risks of extension in the IVC and PE, leading to prolonged hospitalisation including in the ICU. Therapeutic anticoagulation and antibiotics, when infection is documented, should be considered for management.PMID:33834605 | DOI:10.1111/jth.15333 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - April 9, 2021 Category: Hematology Authors: Marijke Allain Wouterlood Isabelle Malhame Kateri Levesque Natalie Dayan Mich èle Mahone Anne-Marie C ôté Annabelle Cumyn Mandy Malick Nadine Sauv é Source Type: research

Multidimensional flow cytometry reveals novel platelet subpopulations in response to prostacyclin
CONCLUSION: The combination of multicolour flow cytometry assays with unbiased computational tools has identified novel platelet subpopulations that suggest differential regulation of platelet functions by PGI2 . Development of this approach with increased surface and intracellular markers will allow the identification of rare platelet subtypes and novel biomarkers.PMID:33834609 | DOI:10.1111/jth.15330 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - April 9, 2021 Category: Hematology Authors: Matthew S Hindle Benjamin Ej Spurgeon Lih T Cheah Beth A Webb Khalid M Naseem Source Type: research

Thrombolytic strategies for ischemic stroke in the thrombectomy era
J Thromb Haemost. 2021 Apr 9. doi: 10.1111/jth.15336. Online ahead of print.ABSTRACTTwenty-five years ago, intravenous thrombolysis has revolutionized the care of patients with acute ischemic stroke. Since 2015, randomized clinical trials have demonstrated that mechanical thrombectomy improves functional outcome in stroke patients over intravenous thrombolysis alone. More recently, three randomized clinical trials have suggested that mechanical thrombectomy alone is non-inferior to a combined strategy with both intravenous thrombolysis and mechanical thrombectomy. In the present review, we will present the last clinical an...
Source: Thrombosis and Haemostasis - April 9, 2021 Category: Hematology Authors: Maxime Gauberti Sara Martinez de Lizarrondo Denis Vivien Source Type: research

A Simplified Decision Rule to Rule Out Deep Vein Thrombosis Using Clinical Assessment And D-dimer
J Thromb Haemost. 2021 Apr 8. doi: 10.1111/jth.15337. Online ahead of print.ABSTRACTBACKGROUND: Current clinical decision rules to exclude deep vein thrombosis (DVT) are underutilized partly because of their complexity. A simplified rule that can be easily applied would be more appealing to use in clinical practice.METHODS: We used individual patient data from prospective diagnostic studies of patients suspected of DVT to develop a new clinical decision rule. The primary outcome was presence of DVT either at initial testing or during follow-up. DVT was considered safely excluded if the upper 95% confidence interval of DVT prevalence was
Source: Thrombosis and Haemostasis - April 9, 2021 Category: Hematology Authors: Keying Xu Kerstin de Wit Geert-Jan Geersing Toshihiko Takada Roger Schutgens Johan Elf Clive Kearon Sameer Parpia Source Type: research

Structure-function of anticoagulant TIX-5, the inhibitor of Factor Xa-mediated FV activation
CONCLUSION: The structure-function properties of TIX-5 are in perfect agreement with a protein that inhibits the FXa-mediated activation on a phospholipid surface. The present elucidation of the mechanism of action of TIX-5 will aid in deciphering the processes involved in the initiation phase of blood coagulation.PMID:33829620 | DOI:10.1111/jth.15329 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - April 8, 2021 Category: Hematology Authors: Anja Maag Priyanka Sharma Tim J Schuijt Wil F Kopatz Dani ëlle Kruijswijk J Arnoud Marquart Tom van der Poll Tilman M Hackeng Gerry A F Nicolaes Joost C M Meijers Mettine H A Bos Cornelis van 't Veer Source Type: research

Gene and protein expression in human megakaryocytes derived from induced pluripotent stem cells
Conclusions MKs expressed genes and proteins known to be important in MK and platelet function and demonstrated good agreement with previous studies in human MKs derived from CD34+ progenitor cells. The percent of cells expressing the MK markers CD41 and CD42a was consistent in biological replicates, but variable across subjects, suggesting that unidentified subject-specific factors determine differentiation of MKs from iPSCs. Gene and protein sets important in platelet function were associated with increasing expression of CD41/42a, while those related to more basic cellular functions were associated with lower CD41/42a e...
Source: Thrombosis and Haemostasis - April 8, 2021 Category: Hematology Authors: Kai Kammers Margaret A Taub Rasika A Mathias Lisa R Yanek Kanika Kanchan Vidya Venkatraman Niveda Sundararaman Joshua Martin Senquan Liu Dixie Hoyle Koen Raedschelders Ronald Holewinski Sarah Parker Victoria Dardov Nauder Faraday Diane M Becker Linzhao Ch Source Type: research

Sex-specific differences in clot resolution 3 weeks after acute pulmonary embolism managed with anticoagulants - a substudy of the Einstein-PE study
CONCLUSIONS: A total of 371 participants including 174 (46.9%) women and 197 (53.0%) men were included in the present analysis. At 3 weeks, there was no difference between men and women in complete clot resolution: 39.6% and 40.2%, respectively. The absolute reduction in pulmonary vascular obstruction at week 3 was also similar: 12.9% (95% CI: 11.6 to 14.2) in men and 12.1% (95% CI: 10.4 to 13.7) in women, corresponding to a resolution ratio of 0.29 (95% CI: 0.24 to 0.33) and 0.35 (95% CI: 0.28 to 0.42), respectively No differences in clot resolution were observed between men and women diagnosed with acute PE at 3 weeks af...
Source: Thrombosis and Haemostasis - April 8, 2021 Category: Hematology Authors: Hanke M G Wiegers Josien van Es Ákos F Pap Anthonie W A Lensing Saskia Middeldorp Luuk J J Scheres Source Type: research

Placental growth factor level in plasma predicts COVID-19 severity and in-hospital mortality
J Thromb Haemost. 2021 Apr 8. doi: 10.1111/jth.15339. Online ahead of print.ABSTRACTBACKGROUND: Coronavirus disease 2019 (COVID-19) is a respiratory disease associated with vascular inflammation and endothelial injury.OBJECTIVES: Correlate circulating angiogenic markers VEGF-A, PlGF and FGF-2 to in-hospital mortality in COVID-19 adult patients.METHODS: Consecutive ambulatory and hospitalized patients with COVID-19 infection were enrolled. VEGF-A, PlGF and FGF-2 were measured in each patient ≤48 h following admission.RESULTS: Study enrolled 237 patients with suspected COVID-19: 208 patients had a positive diagnostic for ...
Source: Thrombosis and Haemostasis - April 8, 2021 Category: Hematology Authors: David M Smadja Aur élien Philippe Olivier Bory Nicolas Gendron Agathe Beauvais Maxime Gruest Nicolas Peron Lina Khider Coralie L Guerin Guillaume Goudot Fran çoise Levavasseur J érome Duchemin Fr édéric Pene Cherifa Cheurfa Tali-Anne Szwebel Elise So Source Type: research

CD248 enhances tissue factor (TF) procoagulant function, promoting arterial and venous thrombosis in mouse models
We examined whether CD248 also participates in thrombosis.METHODS: We evaluated the role of CD248 in coagulation using mouse models of vascular injury, and by assessing its functional interaction with the TF-factor VIIa (FVIIa)-FX complex.RESULTS: The time to ferric chloride-induced occlusion of the carotid artery in CD248 KO mice was significantly longer than in WT mice. In an inferior vena cava (IVC) stenosis model of thrombosis, lack of CD248 conferred relative resistance to thrombus formation when compared to WT mice. Levels of circulating cells and coagulation factors, PT, aPTT and tail bleeding times were similar in ...
Source: Thrombosis and Haemostasis - April 8, 2021 Category: Hematology Authors: Piyushkumar R Kapopara Nooshin S Safikhan Jenny L Huang Scott C Meixner Kevin Gonzalez Houra Loghmani Wolfram Ruf Alan E Mast Victor Lei Edward L G Pryzdial Edward M Conway Source Type: research

Anticoagulant treatment of COVID-19 as early as possible - Sulodexide and perspectives
Thromb Haemost. 2021 Apr 8. doi: 10.1055/a-1477-3569. Online ahead of print.ABSTRACTNo Abstract.PMID:33831961 | DOI:10.1055/a-1477-3569 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - April 8, 2021 Category: Hematology Authors: Sam Schulman Job Harenberg Source Type: research

Significant major bleeding in hospitalized patients with COVID-19 receiving thromboprophylaxis
Thromb Haemost. 2021 Apr 8. doi: 10.1055/a-1477-4027. Online ahead of print.ABSTRACTNo Abstract.PMID:33831962 | DOI:10.1055/a-1477-4027 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - April 8, 2021 Category: Hematology Authors: Vicky Mai Sabine Mainbourg Boun Kim Tan Jean-Christophe Lega Steeve Provencher Source Type: research

A Systematic Review of Anticoagulation Strategies for Patients With Atrial Fibrillation in Critical Care
CONCLUSIONS: There was an increased incidence of major bleeding events in anticoagulated patients with AF in critical care compared to non-anticoagulated patients. There was no significant difference in the incidence of reported thromboembolic events within studies, between patients who did and did not receive anticoagulation. However, the outcomes reported within studies were not standardised, therefore, the generalisability of our results to the general critical care population remains unclear. Further data is required to facilitate an evidence-based assessment of the risks and benefits of anticoagulation for critically ...
Source: Thrombosis and Haemostasis - April 8, 2021 Category: Hematology Authors: Alexandra Jayne Nelson Brian W Johnston Alicia Achiaa Charlotte Waite Gedeon Lemma Ingeborg Dorothea Welters Source Type: research

Platelet count rose while D-dimer levels dropped as deaths and thrombosis declined, an observational study on anticoagulation shift in COVID-19
CONCLUSIONS: In contrast to D-dimer levels, increase of platelet count over the first week in-hospital was associated with improved survival and reduced thrombotic risk. The daily mean levels of D-dimer dropped while the platelet counts rose, coinciding with increased anticoagulation and a decline in thrombotic burden and mortality.PMID:33831964 | DOI:10.1055/a-1477-3829 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - April 8, 2021 Category: Hematology Authors: Anna Sj öström Johanna Wers äll Anna Warnqvist Maria Farm Maria Magnusson Anders Oldner Anna Ågren Jovan P Antovic Maria Bruzelius Source Type: research

Discovery of plasma biomarkers with data-independent acquisition mass spectrometry and antibody microarray for diagnosis and risk stratification of pulmonary embolism
CONCLUSION: As predictors of inflammation or injury repair, SAA1, S100A8, and TNC are potential plasma biomarkers for the diagnosis and risk stratification of PE.PMID:33825327 | DOI:10.1111/jth.15324 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - April 7, 2021 Category: Hematology Authors: Bingqing Han Chuanbao Li Hexin Li Ying Li Xuanmei Luo Ye Liu Junhua Zhang Zhu Zhang Xiaobo Yu Zhenguo Zhai Xiaomao Xu Fei Xiao Source Type: research

Biomarkers of coagulation, endothelial function and fibrinolysis in critically-ill patients with COVID-19: A single-centre prospective longitudinal study
CONCLUSIONS: Longitudinal trajectories of clot lysis time, sTM, PAI-1, and plasminogen may have predictive ability for mortality in COVID-19.PMID:33826233 | DOI:10.1111/jth.15327 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - April 7, 2021 Category: Hematology Authors: Ganeem K Juneja Matthew Castelo Calvin H Yeh Samantha E Cerroni Bettina E Hansen James E Chessum Joel Abraham Erblin Cani Dhruva J Dwivedi Douglas D Fraser Marat Slessarev Claudio Martin Scott McGilvray Peter L Gross Patricia C Liaw Jeffrey I Weitz Paul Y Source Type: research

Discovery of plasma biomarkers with data-independent acquisition mass spectrometry and antibody microarray for diagnosis and risk stratification of pulmonary embolism
CONCLUSION: As predictors of inflammation or injury repair, SAA1, S100A8, and TNC are potential plasma biomarkers for the diagnosis and risk stratification of PE.PMID:33825327 | DOI:10.1111/jth.15324 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - April 7, 2021 Category: Hematology Authors: Bingqing Han Chuanbao Li Hexin Li Ying Li Xuanmei Luo Ye Liu Junhua Zhang Zhu Zhang Xiaobo Yu Zhenguo Zhai Xiaomao Xu Fei Xiao Source Type: research

Biomarkers of coagulation, endothelial function and fibrinolysis in critically-ill patients with COVID-19: A single-centre prospective longitudinal study
CONCLUSIONS: Longitudinal trajectories of clot lysis time, sTM, PAI-1, and plasminogen may have predictive ability for mortality in COVID-19.PMID:33826233 | DOI:10.1111/jth.15327 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - April 7, 2021 Category: Hematology Authors: Ganeem K Juneja Matthew Castelo Calvin H Yeh Samantha E Cerroni Bettina E Hansen James E Chessum Joel Abraham Erblin Cani Dhruva J Dwivedi Douglas D Fraser Marat Slessarev Claudio Martin Scott McGilvray Peter L Gross Patricia C Liaw Jeffrey I Weitz Paul Y Source Type: research

Risk of thrombotic complications in influenza versus COVID-19 hospitalized patients
CONCLUSIONS: The incidence of thrombotic complications in hospitalized influenza patients was lower than in hospitalized COVID-19 patients. This difference was mainly driven by a high risk of VTE complications in the COVID-19 patients admitted to ICU. Remarkably, influenza patients were more often diagnosed with arterial thrombotic complications.PMID:33821230 | PMC:PMC8014477 | DOI:10.1002/rth2.12496 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - April 6, 2021 Category: Hematology Authors: Mam Stals Mjjh Grootenboers C van Guldener Fhj Kaptein Sje Braken Q Chen G Chu E M van Driel A Iglesias Del Sol E de Jonge K M Kant F Pals Mma Toorop S C Cannegieter F A Klok M V Huisman Dutch COVID, Thrombosis Coalition (DCTC) Source Type: research

Validation of the 2019 European Society of Cardiology risk stratification algorithm for pulmonary embolism in normotensive elderly patients
CONCLUSIONS: While categorizing more patients in higher-risk groups, the 2019 ESC algorithm for PE did not improve prediction of short-term outcomes compared to the 2014 ESC algorithm or the PESI.PMID:33823559 | DOI:10.1055/a-1475-2263 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - April 6, 2021 Category: Hematology Authors: Jeanne Moor Christine Baumgartner Marie M éan Odile Stalder Andreas Limacher Nicolas Rodondi Drahomir Aujesky Source Type: research

Treatment-dose LMWH versus prophylactic/intermediate dose heparins in high risk COVID-19 inpatients: Rationale and design of the HEP-COVID Trial
Thromb Haemost. 2021 Apr 6. doi: 10.1055/a-1475-2351. Online ahead of print.ABSTRACTCoronavirus disease-2019 (COVID-19) has been associated with significant risk of venous thromboembolism (VTE), arterial thromboembolism (ATE), and mortality particularly among hospitalized patients with critical illness and elevated D-dimer (Dd) levels. Conflicting data have yet to elucidate optimal thromboprophylaxis dosing. HEP-COVID (NCT04401293) is a Phase 3, multicenter, pragmatic, prospective, randomized, pseudo-blinded, active control trial to evaluate efficacy and safety of therapeutic-dose low molecular weight heparin (LMWH) versus...
Source: Thrombosis and Haemostasis - April 6, 2021 Category: Hematology Authors: Mark Goldin Dimitrios Giannis Wassim Diab Janice Wang Sameer Khanijo Gulru Sharifova Marc Cohen Jeet M Lund Andrea Mignatti Eugenia Gianos Alfonso Tafur Paul A Lewis Kevin Cohoon John M Kittelson Martin Lesser Cristina P Sison Husneara Rahman Kanta Ochani Source Type: research

Risk of thrombotic complications in influenza versus COVID-19 hospitalized patients
CONCLUSIONS: The incidence of thrombotic complications in hospitalized influenza patients was lower than in hospitalized COVID-19 patients. This difference was mainly driven by a high risk of VTE complications in the COVID-19 patients admitted to ICU. Remarkably, influenza patients were more often diagnosed with arterial thrombotic complications.PMID:33821230 | PMC:PMC8014477 | DOI:10.1002/rth2.12496 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - April 6, 2021 Category: Hematology Authors: Mam Stals Mjjh Grootenboers C van Guldener Fhj Kaptein Sje Braken Q Chen G Chu E M van Driel A Iglesias Del Sol E de Jonge K M Kant F Pals Mma Toorop S C Cannegieter F A Klok M V Huisman Dutch COVID, Thrombosis Coalition (DCTC) Source Type: research

Thrombin generation potential in the presence of concizumab and rFVIIa, aPCC, rFVIII or rFIX: In vitro and ex vivo analyses
CONCLUSION: rFVIIa, aPCC, rFVIII and rFIX enhanced plasma TG potential in the presence of concizumab. Dose levels of concomitant use should be adjusted accordingly to balance potential safety concerns while maintaining the necessary hemostatic effect.PMID:33819375 | DOI:10.1111/jth.15323 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - April 5, 2021 Category: Hematology Authors: Marianne Kjalke Mads Kjelgaard-Hansen S øren Andersen Ida Hilden Source Type: research

The concept of rebalanced hemostasis in patients with liver disease: Communication from the ISTH SSC working group on hemostatic management of patients with liver disease
J Thromb Haemost. 2021 Apr;19(4):1116-1122. doi: 10.1111/jth.15239.ABSTRACTPatients with liver diseases acquire complex alterations in their hemostatic system that may lead to abnormalities in routine diagnostic test of hemostasis. Thrombocytopenia, prolongations in the prothrombin time and activated partial thromboplastin time, and decreased plasma fibrinogen are common in patients with advanced liver disease. Historically, liver diseases therefore have been classified as an acquired bleeding disorder. Laboratory and clinical observations have demonstrated that although routine diagnostic tests of hemostasis suggest a hyp...
Source: Thrombosis and Haemostasis - April 1, 2021 Category: Hematology Authors: Ton Lisman Virginia Hernandez-Gea Maria Magnusson Lara Roberts Simon Stanworth Jecko Thachil Armando Tripodi Source Type: research

The carboxyl-terminal region of coagulation serine proteases: A matter of cut and change
J Thromb Haemost. 2021 Apr;19(4):917-919. doi: 10.1111/jth.15237.NO ABSTRACTPMID:33792173 | DOI:10.1111/jth.15237 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - April 1, 2021 Category: Hematology Authors: Alessio Branchini Source Type: research

Comment on the article by Toorop et al.: "The relationship between DOAC levels and clinical outcomes: The measures tell the tale"
J Thromb Haemost. 2021 Apr;19(4):1134-1136. doi: 10.1111/jth.15245.NO ABSTRACTPMID:33792174 | DOI:10.1111/jth.15245 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - April 1, 2021 Category: Hematology Authors: Enrico Brunetti Mario Bo Source Type: research

Definition of haemostatic effectiveness in interventions used to treat major bleeding: Communication from the ISTH SSC Subcommittee on Control of Anticoagulation
J Thromb Haemost. 2021 Apr;19(4):1112-1115. doi: 10.1111/jth.15222.NO ABSTRACTPMID:33792175 | DOI:10.1111/jth.15222 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - April 1, 2021 Category: Hematology Authors: Nakisa Khorsand Jan Beyer-Westendorf Ravi Sarode Sam Schulman Karina Meijer Source Type: research

International pediatric thrombosis network to advance pediatric thrombosis research: Communication from the ISTH SSC subcommittee on pediatric and neonatal thrombosis and hemostasis
J Thromb Haemost. 2021 Apr;19(4):1123-1129. doi: 10.1111/jth.15260.ABSTRACTPediatric thromboembolism is a rare and heterogenous disease. As a result, there is a paucity of knowledge with regard to natural history, management, and outcomes of most types of pediatric venous and arterial thromboembolism. International research collaboration is needed to fill these knowledge gaps. Not only randomized controlled trials, but also representative observational studies are required to answer all research questions. Therefore, the ISTH SSC Subcommittee on Pediatric and Neonatal Thrombosis and Hemostasis initiated the International P...
Source: Thrombosis and Haemostasis - April 1, 2021 Category: Hematology Authors: C Heleen van Ommen Manuela Albisetti Mohir Bhatt Marianne Bonduel Brian Branchford Elizabeth Chalmers Anthony Chan Neil A Goldenberg Susanne Holzhauer Paul Monagle Ulrike Nowak-G öttl Shoshana Revel-Vilk Gabriela Sciuccatie Nongnuch Sirachainan Christoph Source Type: research

What the neighbors say
J Thromb Haemost. 2021 Apr;19(4):885-886. doi: 10.1111/jth.15285.NO ABSTRACTPMID:33792177 | DOI:10.1111/jth.15285 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - April 1, 2021 Category: Hematology Source Type: research

The relationship between DOAC levels and clinical outcomes: The measures tell the tale-Response from original authors Lijfering et al
J Thromb Haemost. 2021 Apr;19(4):1136-1138. doi: 10.1111/jth.15248.NO ABSTRACTPMID:33792178 | DOI:10.1111/jth.15248 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - April 1, 2021 Category: Hematology Authors: Myrthe M A Toorop Luuk J J Scheres Willem M Lijfering Source Type: research

Making treatment decisions in hemophilia based on available safety data
J Thromb Haemost. 2021 Apr;19(4):1138-1139. doi: 10.1111/jth.15255.NO ABSTRACTPMID:33792179 | DOI:10.1111/jth.15255 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - April 1, 2021 Category: Hematology Authors: Mike Makris Cedric Hermans Source Type: research

The concept of rebalanced hemostasis in patients with liver disease: Communication from the ISTH SSC working group on hemostatic management of patients with liver disease
J Thromb Haemost. 2021 Apr;19(4):1116-1122. doi: 10.1111/jth.15239.ABSTRACTPatients with liver diseases acquire complex alterations in their hemostatic system that may lead to abnormalities in routine diagnostic test of hemostasis. Thrombocytopenia, prolongations in the prothrombin time and activated partial thromboplastin time, and decreased plasma fibrinogen are common in patients with advanced liver disease. Historically, liver diseases therefore have been classified as an acquired bleeding disorder. Laboratory and clinical observations have demonstrated that although routine diagnostic tests of hemostasis suggest a hyp...
Source: Thrombosis and Haemostasis - April 1, 2021 Category: Hematology Authors: Ton Lisman Virginia Hernandez-Gea Maria Magnusson Lara Roberts Simon Stanworth Jecko Thachil Armando Tripodi Source Type: research

The carboxyl-terminal region of coagulation serine proteases: A matter of cut and change
J Thromb Haemost. 2021 Apr;19(4):917-919. doi: 10.1111/jth.15237.NO ABSTRACTPMID:33792173 | DOI:10.1111/jth.15237 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - April 1, 2021 Category: Hematology Authors: Alessio Branchini Source Type: research

Comment on the article by Toorop et al.: "The relationship between DOAC levels and clinical outcomes: The measures tell the tale"
J Thromb Haemost. 2021 Apr;19(4):1134-1136. doi: 10.1111/jth.15245.NO ABSTRACTPMID:33792174 | DOI:10.1111/jth.15245 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - April 1, 2021 Category: Hematology Authors: Enrico Brunetti Mario Bo Source Type: research

Definition of haemostatic effectiveness in interventions used to treat major bleeding: Communication from the ISTH SSC Subcommittee on Control of Anticoagulation
J Thromb Haemost. 2021 Apr;19(4):1112-1115. doi: 10.1111/jth.15222.NO ABSTRACTPMID:33792175 | DOI:10.1111/jth.15222 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - April 1, 2021 Category: Hematology Authors: Nakisa Khorsand Jan Beyer-Westendorf Ravi Sarode Sam Schulman Karina Meijer Source Type: research

International pediatric thrombosis network to advance pediatric thrombosis research: Communication from the ISTH SSC subcommittee on pediatric and neonatal thrombosis and hemostasis
J Thromb Haemost. 2021 Apr;19(4):1123-1129. doi: 10.1111/jth.15260.ABSTRACTPediatric thromboembolism is a rare and heterogenous disease. As a result, there is a paucity of knowledge with regard to natural history, management, and outcomes of most types of pediatric venous and arterial thromboembolism. International research collaboration is needed to fill these knowledge gaps. Not only randomized controlled trials, but also representative observational studies are required to answer all research questions. Therefore, the ISTH SSC Subcommittee on Pediatric and Neonatal Thrombosis and Hemostasis initiated the International P...
Source: Thrombosis and Haemostasis - April 1, 2021 Category: Hematology Authors: C Heleen van Ommen Manuela Albisetti Mohir Bhatt Marianne Bonduel Brian Branchford Elizabeth Chalmers Anthony Chan Neil A Goldenberg Susanne Holzhauer Paul Monagle Ulrike Nowak-G öttl Shoshana Revel-Vilk Gabriela Sciuccatie Nongnuch Sirachainan Christoph Source Type: research

What the neighbors say
J Thromb Haemost. 2021 Apr;19(4):885-886. doi: 10.1111/jth.15285.NO ABSTRACTPMID:33792177 | DOI:10.1111/jth.15285 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - April 1, 2021 Category: Hematology Source Type: research

The relationship between DOAC levels and clinical outcomes: The measures tell the tale-Response from original authors Lijfering et al
J Thromb Haemost. 2021 Apr;19(4):1136-1138. doi: 10.1111/jth.15248.NO ABSTRACTPMID:33792178 | DOI:10.1111/jth.15248 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - April 1, 2021 Category: Hematology Authors: Myrthe M A Toorop Luuk J J Scheres Willem M Lijfering Source Type: research

Making treatment decisions in hemophilia based on available safety data
J Thromb Haemost. 2021 Apr;19(4):1138-1139. doi: 10.1111/jth.15255.NO ABSTRACTPMID:33792179 | DOI:10.1111/jth.15255 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - April 1, 2021 Category: Hematology Authors: Mike Makris Cedric Hermans Source Type: research

The concept of rebalanced hemostasis in patients with liver disease: Communication from the ISTH SSC working group on hemostatic management of patients with liver disease
J Thromb Haemost. 2021 Apr;19(4):1116-1122. doi: 10.1111/jth.15239.ABSTRACTPatients with liver diseases acquire complex alterations in their hemostatic system that may lead to abnormalities in routine diagnostic test of hemostasis. Thrombocytopenia, prolongations in the prothrombin time and activated partial thromboplastin time, and decreased plasma fibrinogen are common in patients with advanced liver disease. Historically, liver diseases therefore have been classified as an acquired bleeding disorder. Laboratory and clinical observations have demonstrated that although routine diagnostic tests of hemostasis suggest a hyp...
Source: Thrombosis and Haemostasis - April 1, 2021 Category: Hematology Authors: Ton Lisman Virginia Hernandez-Gea Maria Magnusson Lara Roberts Simon Stanworth Jecko Thachil Armando Tripodi Source Type: research

The carboxyl-terminal region of coagulation serine proteases: A matter of cut and change
J Thromb Haemost. 2021 Apr;19(4):917-919. doi: 10.1111/jth.15237.NO ABSTRACTPMID:33792173 | DOI:10.1111/jth.15237 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - April 1, 2021 Category: Hematology Authors: Alessio Branchini Source Type: research

Comment on the article by Toorop et al.: "The relationship between DOAC levels and clinical outcomes: The measures tell the tale"
J Thromb Haemost. 2021 Apr;19(4):1134-1136. doi: 10.1111/jth.15245.NO ABSTRACTPMID:33792174 | DOI:10.1111/jth.15245 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - April 1, 2021 Category: Hematology Authors: Enrico Brunetti Mario Bo Source Type: research

Definition of haemostatic effectiveness in interventions used to treat major bleeding: Communication from the ISTH SSC Subcommittee on Control of Anticoagulation
J Thromb Haemost. 2021 Apr;19(4):1112-1115. doi: 10.1111/jth.15222.NO ABSTRACTPMID:33792175 | DOI:10.1111/jth.15222 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - April 1, 2021 Category: Hematology Authors: Nakisa Khorsand Jan Beyer-Westendorf Ravi Sarode Sam Schulman Karina Meijer Source Type: research

International pediatric thrombosis network to advance pediatric thrombosis research: Communication from the ISTH SSC subcommittee on pediatric and neonatal thrombosis and hemostasis
J Thromb Haemost. 2021 Apr;19(4):1123-1129. doi: 10.1111/jth.15260.ABSTRACTPediatric thromboembolism is a rare and heterogenous disease. As a result, there is a paucity of knowledge with regard to natural history, management, and outcomes of most types of pediatric venous and arterial thromboembolism. International research collaboration is needed to fill these knowledge gaps. Not only randomized controlled trials, but also representative observational studies are required to answer all research questions. Therefore, the ISTH SSC Subcommittee on Pediatric and Neonatal Thrombosis and Hemostasis initiated the International P...
Source: Thrombosis and Haemostasis - April 1, 2021 Category: Hematology Authors: C Heleen van Ommen Manuela Albisetti Mohir Bhatt Marianne Bonduel Brian Branchford Elizabeth Chalmers Anthony Chan Neil A Goldenberg Susanne Holzhauer Paul Monagle Ulrike Nowak-G öttl Shoshana Revel-Vilk Gabriela Sciuccatie Nongnuch Sirachainan Christoph Source Type: research

What the neighbors say
J Thromb Haemost. 2021 Apr;19(4):885-886. doi: 10.1111/jth.15285.NO ABSTRACTPMID:33792177 | DOI:10.1111/jth.15285 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - April 1, 2021 Category: Hematology Source Type: research

The relationship between DOAC levels and clinical outcomes: The measures tell the tale-Response from original authors Lijfering et al
J Thromb Haemost. 2021 Apr;19(4):1136-1138. doi: 10.1111/jth.15248.NO ABSTRACTPMID:33792178 | DOI:10.1111/jth.15248 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - April 1, 2021 Category: Hematology Authors: Myrthe M A Toorop Luuk J J Scheres Willem M Lijfering Source Type: research

Making treatment decisions in hemophilia based on available safety data
J Thromb Haemost. 2021 Apr;19(4):1138-1139. doi: 10.1111/jth.15255.NO ABSTRACTPMID:33792179 | DOI:10.1111/jth.15255 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - April 1, 2021 Category: Hematology Authors: Mike Makris Cedric Hermans Source Type: research

The concept of rebalanced hemostasis in patients with liver disease: Communication from the ISTH SSC working group on hemostatic management of patients with liver disease
J Thromb Haemost. 2021 Apr;19(4):1116-1122. doi: 10.1111/jth.15239.ABSTRACTPatients with liver diseases acquire complex alterations in their hemostatic system that may lead to abnormalities in routine diagnostic test of hemostasis. Thrombocytopenia, prolongations in the prothrombin time and activated partial thromboplastin time, and decreased plasma fibrinogen are common in patients with advanced liver disease. Historically, liver diseases therefore have been classified as an acquired bleeding disorder. Laboratory and clinical observations have demonstrated that although routine diagnostic tests of hemostasis suggest a hyp...
Source: Thrombosis and Haemostasis - April 1, 2021 Category: Hematology Authors: Ton Lisman Virginia Hernandez-Gea Maria Magnusson Lara Roberts Simon Stanworth Jecko Thachil Armando Tripodi Source Type: research

The carboxyl-terminal region of coagulation serine proteases: A matter of cut and change
J Thromb Haemost. 2021 Apr;19(4):917-919. doi: 10.1111/jth.15237.NO ABSTRACTPMID:33792173 | DOI:10.1111/jth.15237 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - April 1, 2021 Category: Hematology Authors: Alessio Branchini Source Type: research

Comment on the article by Toorop et al.: "The relationship between DOAC levels and clinical outcomes: The measures tell the tale"
J Thromb Haemost. 2021 Apr;19(4):1134-1136. doi: 10.1111/jth.15245.NO ABSTRACTPMID:33792174 | DOI:10.1111/jth.15245 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - April 1, 2021 Category: Hematology Authors: Enrico Brunetti Mario Bo Source Type: research