Safety of apixaban for cancer-associated thrombosis.
nez D Abstract No Abstract. PMID: 33472252 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - January 20, 2021 Category: Hematology Authors: Bikdeli B, Jiménez D Tags: Thromb Haemost Source Type: research

Long-term Effects of Apixaban Confirmed in The Open-Label Extension of AVERROES Trial.
Abstract No Abstract. PMID: 33472253 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - January 20, 2021 Category: Hematology Authors: Chao TF, Potpara TS Tags: Thromb Haemost Source Type: research

Antiphospholipid Syndrome with Monoclonal Gammopathy - A Mechanism for Recurrent Thrombosis?
Abstract Not Applicable. PMID: 33472254 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - January 20, 2021 Category: Hematology Authors: Doyle A, Breen K, Hunt B Tags: Thromb Haemost Source Type: research

Prevalence and Predictors of Venous Thromboembolism or Mortality in Hospitalized COVID-19 Patients.
CONCLUSION: In our large cohort of hospitalized COVID-19 patients, the overall in-hospital VTE rate was 2.9% (4.9% in the ICU) and a VTE or mortality rate of 26.1%. Key predictors of VTE or mortality included advanced age, increasing CCI, history of cardiovascular disease, ICU level of care, and elevated maximum D-dimer with a cutoff at least 4 times the ULN. Use of prophylactic-dose anticoagulation but not treatment-dose anticoagulation was associated with reduced VTE or mortality. PMID: 33472255 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - January 20, 2021 Category: Hematology Authors: Cohen SL, Gianos E, Barish MA, Chatterjee S, Kohn N, Lesser M, Giannis D, Coppa K, Hirsch J, McGinn T, Goldin M, Spyropoulos A Tags: Thromb Haemost Source Type: research

"Part of the Ritual": Exploring patient and physician decision-making regarding anticoagulation use in obstetric antiphospholipid syndrome.
CONCLUSIONS: Our findings should be considered when designing future research on studying the role for LMWH/ASA in this population, as it suggests that the perceived benefits of treatment go beyond improving pregnancy rates. Rather, patients described potential benefit from the process of taking action, even in the absence of a guaranteed good outcome. PMID: 33472256 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - January 20, 2021 Category: Hematology Authors: Skeith L, Rodger M, Bates SM, Gonsalves C, Karovitch A, Taylor T Tags: Thromb Haemost Source Type: research

Platelet α-Granule Cargo Packaging and Release are Affected by the Luminal Proteoglycan, Serglycin.
CONCLUSION: The polyanionic proteoglycan SRGN influences α-granule packaging, cargo release, and shedding of platelet membrane proteins. PMID: 33448622 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - January 15, 2021 Category: Hematology Authors: Chanzu H, Lykins J, Wigna-Kumar S, Joshi S, Pokrovskaya I, Storrie B, Pejler G, Wood JP, Whiteheart SW Tags: J Thromb Haemost Source Type: research

Transfusion with Cryoprecipitate for Very Low Fibrinogen Levels Does Not Affect Bleeding or Survival in Critically Ill Cirrhosis Patients.
CONCLUSIONS: In cirrhosis patients with critical illness, low FIB levels on presentation reflect severity of illness but are not independently associated with 30-day mortality. Treatment of low FIB with CRYO also does not affect survival or bleeding complications suggesting FIB is an additional marker of severity of illness but is not itself a direct factor in the pathophysiology of bleeding in critically ill cirrhosis patients. PMID: 33450778 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - January 15, 2021 Category: Hematology Authors: Budnick I, Davis J, Sundararaghavan A, Konkol S, Lau C, Alsobrooks J, Stotts M, Intagliata N, Lisman T, Northup P Tags: Thromb Haemost Source Type: research

Comparison of Different Clinical Prognostic Scores in Patients with Pulmonary Embolism and Active Cancer.
CONCLUSIONS: Cancer-specific PE prognostic scores (RIETE and POMPE-C) performed better than generic scales (PESI and Hestia) and a cancer-specific VTE prognostic scale (modified Ottawa) in identifying low-risk PE patients with active cancer who may be suitable for outpatient treatment. PMID: 33450779 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - January 15, 2021 Category: Hematology Authors: Li XQ, Hu YH, Lin P, Zhang JR, Tang YJ, Yi Q, Liang ZA, Zhou H, Wang MY Tags: Thromb Haemost Source Type: research

Target-Mediated Drug Disposition (TMDD) Modeling of an Anti-TFPI Antibody (MG1113) in Cynomolgus Monkeys to Predict Human Pharmacokinetics and Pharmacodynamics.
CONCLUSIONS: MG1113 showed nonlinear PK after both IV and SC administrations at the dosing range from 2.5~10 mg/kg. The concentrations of MG1113 vs. TFPI could be characterized a dose-response relationship using a TMDD model. The TMDD modeling and simulation built in this study were used to simulate various dosage regimens of MG1113 to apply to the first-in-human study design, and moreover expected to be referred to establish the dose for further clinical trials. PMID: 33448093 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - January 14, 2021 Category: Hematology Authors: Kwak EY, Kim MJ, Park JH, Jung HW, Jung ME Tags: J Thromb Haemost Source Type: research

NETosis Markers in Pregnancy: Effects Differ According to Histone Subtypes.
Abstract NETosis is an innate immune response occurring after infection or inflammation: activated neutrophils expel decondensed DNA in complex with histones into the extracellular environment in a controlled manner. It activates coagulation and fuels the risk of thrombosis. Human pregnancy is associated with a mild proinflammatory state characterized by circulatory neutrophil activation which is further increased in complicated pregnancies, placenta-mediated complications being associated with an increased thrombotic risk. This aberrant activation leads to an increased release of nucleosomes in the blood flow. Th...
Source: Thrombosis and Haemostasis - January 10, 2021 Category: Hematology Authors: Bouvier S, Fortier M, Vincent L, Demattei C, Mousty E, Herzog M, Rommelaere G, Nouvellon E, Mercier E, Letouzey V, Gris JC Tags: Thromb Haemost Source Type: research

Effect of the First Factor VIII Infusions on Immunological Biomarkers in Previously Untreated Patients with Hemophilia A from the HEMFIL Study.
The objective of this study was to investigate the effect of the first FVIII infusions on immunological biomarkers in previously untreated patients with HA. Plasma samples were collected at enrollment before any FVIII infusion (T0) and at inhibitor development (INB +/T1) or up to 35 exposure days without inhibitors (INB -/T1). Anti-FVIII antibodies (immunoglobulin M, immunoglobulin G [IgG] 1, IgG3, and IgG4), chemokines (CCL2, CCL5, CXCL8, CXCL9, and CXCL10), and cytokines (interleukin [IL]-2, IL-4, IL-6, IL-10, interferon-γ, tumor necrosis factor, and IL-17) were assessed. A total of 71 children with s...
Source: Thrombosis and Haemostasis - January 10, 2021 Category: Hematology Authors: de Oliveira LMM, Jardim LL, Santana MAP, Cerqueira MH, Lorenzato CS, Franco VKB, Zuccherato LW, Rezende SM, Chaves DG Tags: Thromb Haemost Source Type: research

Incidence of Venous Thromboembolism in a Racially Diverse Population of Oklahoma County, Oklahoma.
Abstract BACKGROUND:  Contemporary incidence data for venous thromboembolism (VTE) from racially diverse populations are limited. The racial distribution of Oklahoma County closely mirrors that of the United States. OBJECTIVE:  To evaluate VTE incidence and mortality, including demographic and racial subgroups. DESIGN:  Population-based prospective study. SETTING:  We conducted VTE surveillance at all relevant tertiary care facilities and outpatient clinics in Oklahoma County, Oklahoma during 2012 to 2014, using both active and passive methods. Active surveillance involved review...
Source: Thrombosis and Haemostasis - January 10, 2021 Category: Hematology Authors: Wendelboe AM, Campbell J, Ding K, Bratzler DW, Beckman MG, Reyes NL, Raskob GE Tags: Thromb Haemost Source Type: research

Essential role of a carboxyl-terminal α-helix motif in the secretion of coagulation factor XI.
CONCLUSION: FXI E597Rfs*65 results in the pathogenesis of a severe secretory defect due to aberrant ER-to-Golgi trafficking caused by the lack of a C-terminal α-helix motif. This study demonstrates the impact of the C-terminal structure, especially the α-helix motif, on FXI secretion. PMID: 33421272 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - January 9, 2021 Category: Hematology Authors: Hayakawa Y, Tamura S, Suzuki N, Odaira K, Tokoro M, Kawashima F, Hayakawa F, Takagi A, Katsumi A, Suzuki A, Okamoto S, Kanematsu T, Matsushita T, Kojima T Tags: J Thromb Haemost Source Type: research

Anti- β2-glycoprotein I and anti-prothrombin antibodies cause lupus anticoagulant through different mechanisms of action.
CONCLUSION: Anti-β2GPI and anti-prothrombin antibodies cause LA through different mechanisms of action: while anti-β2GPI antibodies interfere with FV activation by FXa through a direct interaction with FV, anti-prothrombin antibodies compete with FXa for phospholipid binding sites. These data provide leads for understanding the paradoxical association between thrombosis and a prolonged clotting time in the antiphospholipid syndrome. PMID: 33421291 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - January 9, 2021 Category: Hematology Authors: Noordermeer T, Molhoek JE, Schutgens REG, Sebastian SAE, Drost-Verhoef S, van Wesel ACW, de Groot PG, Meijers JCM, Urbanus RT Tags: J Thromb Haemost Source Type: research

Pharmacological targeting of coagulation factor XI mitigates the development of experimental atherosclerosis in low-density lipoprotein receptor-deficient mice.
CONCLUSION: Pharmacological targeting of FXI reduced atherogenesis in Ldlr-/- mice. Interference with the contact activation system may safely reduce development or progression of atherosclerosis. PMID: 33421301 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - January 9, 2021 Category: Hematology Authors: Ngo ATP, Jordan KR, Mueller PA, Hagen MW, Reitsma SE, Puy C, Revenko AS, Lorentz CU, Tucker EI, Cheng Q, Hinds MT, Fazio S, Monia BP, Gailani D, Gruber A, Tavori H, McCarty OJT Tags: J Thromb Haemost Source Type: research

Cycling Exercise Training Enhances Platelet Mitochondrial Bioenergetics in Patients with Peripheral Arterial Disease: A Randomized Controlled Trial.
This study aimed to elucidate the effect of cycling exercise training (CET) on platelet mitochondrial bioenergetics in PAD patients. Forty randomly selected patients with PAD engaged in general rehabilitation (GR) with CET (i.e., cycling exercise at ventilation threshold for 30 minute/day, 3 days/week) (GR + CET, n = 20) or to a control group that only received GR course (n = 20) for 12 weeks. Systemic aerobic capacity and platelet mitochondrial bioenergetics that included oxidative phosphorylation (OXPHOS) and electron transport system (ETS) were measured using automatic ga...
Source: Thrombosis and Haemostasis - January 9, 2021 Category: Hematology Authors: Lin ML, Fu TC, Hsu CC, Huang SC, Lin YT, Wang JS Tags: Thromb Haemost Source Type: research

"The Timing of Venous Thromboembolism in Ovarian Cancer patients. A Nationwide Danish Cohort Study".
CONCLUSIONS: EOC is associated with a high risk of VTE, particularly within the first year after diagnosis. Major pelvic surgery and chemotherapy were strongly associated with VTE. Person related risk factors were increasing age and previous VTE. Advanced stage was an independent tumor-related risk factor. These findings support the indication for thrombosis prophylaxis during chemotherapy. PMID: 33420762 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - January 8, 2021 Category: Hematology Authors: Kahr HS, Christiansen OB, Juul Riddersholm S, Gade IL, Torp-Pedersen C, Knudsen A, Thorlacius-Ussing O Tags: J Thromb Haemost Source Type: research

Endothelial dysfunction, atherosclerosis and increase of Von Willebrand factor and Factor VIII : a randomized controlled trial in swine.
e B Abstract No Abstract. PMID: 33412594 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - January 7, 2021 Category: Hematology Authors: Lämmle B Tags: Thromb Haemost Source Type: research

Platelets are hyperactivated but show reduced glycoprotein VI reactivity in COVID-19 patients.
oll T Abstract No Abstract. PMID: 33412595 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - January 7, 2021 Category: Hematology Authors: Léopold V, Pereverzeva L, Schuurman AR, Reijnders TDY, Saris A, de Brabander J, van Linge CCA, Douma RA, Chouchane O, Nieuwland R, Wiersinga WJ, van 't Veer C, van der Poll T Tags: Thromb Haemost Source Type: research

Heparin in COVID-19 patients is associated with reduced in-hospital mortality: the multicentre Italian CORIST Study.
CONCLUSIONS: In-hospital heparin treatment was associated with lower mortality, particularly in severely ill COVID-19 patients and in those with strong coagulation activation. The results from randomised clinical trials are eagerly awaited to provide clear-cut recommendations. PMID: 33412596 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - January 7, 2021 Category: Hematology Authors: Di Castelnuovo AF, Costanzo S, Iacoviello L Tags: Thromb Haemost Source Type: research

The complex relationship between C4b Binding Protein, warfarin and antiphospholipid antibodies.
Conclusion: Both antiphospholipid antibodies and warfarin are associated with C4BPt reduction. Complement activation in aPL ++ patients may partly be explained by impaired inhibition through depressed C4BPt levels. Further studies are needed to understand the clinical implication. PMID: 33412597 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - January 7, 2021 Category: Hematology Authors: Grosso G, Sandholm K, Antovic AM, Gunnarsson I, Zickert A, Vikerfors A, Truedsson L, Bruzelius M, Nilsson B, Nilsson Ekdahl K, Svenungsson E Tags: Thromb Haemost Source Type: research

Insights from In Vitro and Clinical Data to Guide Transition from the Novel P2Y12 Antagonist Selatogrel to Clopidogrel, Prasugrel, and Ticagrelor.
In conclusion, reduced IPA was observed for clopidogrel and prasugrel when administered after selatogrel, which can be mitigated by applying an appropriate time interval. No PD interaction with ticagrelor was observed. PMID: 33412611 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - January 7, 2021 Category: Hematology Authors: Schilling U, Dingemanse J, Dobrow M, Baumann M, Riederer MA, Juif PE, Ufer M Tags: Thromb Haemost Source Type: research

Inhibitor Index in the Clot Waveform Analysis-Based Mixing Test Differentiates among Hemophilia A without and with Inhibitors, and Lupus Anticoagulant.
CONCLUSION:  The inhibitor index from CWA-based mixing tests with a 12-minute incubation could differentiate among HA, HA-inh, and LA quickly. PMID: 33412612 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - January 7, 2021 Category: Hematology Authors: Shimonishi N, Ogiwara K, Oda Y, Kawabe T, Emmi M, Shima M, Nogami K Tags: Thromb Haemost Source Type: research

Use of Non-vitamin K Antagonist Oral Anticoagulants for Stroke Prevention across the Stroke Spectrum: Progress and Prospects.
Abstract Multiple randomized controlled trials and many real-world evidence studies have consistently shown that non-vitamin K antagonist oral anticoagulants (NOACs) are preferable to vitamin K antagonists for thromboembolic stroke prevention in the majority of patients with atrial fibrillation (AF). However, their role in the management of patients with AF and comorbidities, as well as in other patient populations with a high risk of stroke, such as patients with prior embolic stroke of undetermined source (ESUS) and those with atherosclerosis, is less clear. There is now increasing evidence suggesting that NOACs...
Source: Thrombosis and Haemostasis - January 7, 2021 Category: Hematology Authors: Camm AJ, Atar D Tags: Thromb Haemost Source Type: research

Atrial fibrillation in patients with embolic stroke of undetermined source during 3 years of prolonged monitoring with an implantable loop recorder.
CONCLUSIONS: In ESUS patients, early implantation of an ILR with cardiac monitoring and remote transmission over a 3-year period detects AF in 41.4 % and results in oral anticoagulation in 82% of these patients. PMID: 33401327 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - January 5, 2021 Category: Hematology Authors: Kitsiou A, Rogalewski A, Kalyani M, Deelawar S, Tribunyan S, Greeve I, Minnerup J, Israel C, Schäbitz W Tags: Thromb Haemost Source Type: research

Pharmacodynamic profile in East Asian patients with ACS treated with prasugrel standard-dose v de-escalation strategy: a randomized A-MATCH trial.
Abstract Compared with Caucasian patients, East Asian patients have the unique risk-benefit trade-off and different responsiveness to antithrombotic regimens. The aim of this study was to compare pharmacodynamic profile in East Asian patients with acute coronary syndromes (ACS) treated with prasugrel standard-dose vs. de-escalation strategy. Before discharge, ACS patients with age
Source: Thrombosis and Haemostasis - January 5, 2021 Category: Hematology Authors: Jeong YH, Oh JH, Yoon HJ, Park Y, Suh J, Lee SW, Lee K, Kim JS, Chun WJ, Park YH, Nam CW, Kim JH, Ahn JH, Hwang SJ, Hwang JY, Tantry US, Gurbel P, Shin ES Tags: Thromb Haemost Source Type: research

The effect of anabolic-androgenic steroid abuse on the contact activation system.
Abstract The effect of anabolic-androgenic steroid (AAS) abuse on the contact activation system (CAS) is not known in detail. We hypothesized that current AAS abuse reduces the kallikrein generating capacity of CAS significantly and investigated the impact of AAS on the proteins and capacity of CAS in current and former AAS abusers and healthy age matched controls. Men 18 to 50 years of age were included as current AAS abusers, former AAS abusers or controls. Blood samples were collected after overnight fasting. Kallikrein generation (lag time, peak height, and endogenous kallikrein potential (EKP)), coagulation f...
Source: Thrombosis and Haemostasis - January 5, 2021 Category: Hematology Authors: Sidelmann JJ, Gram JB, Palarasah Y, Rasmussen JJ, Kistorp C Tags: Thromb Haemost Source Type: research

Haemostasis in coronavirus disease 2019 - lesson from viscoelastic methods: a systematic review.
Abstract Haemostatic unbalance is often observed in patients with coronavirus disease 2019 (COVID-19), and patients with severe disease are at high risk of developing thromboembolic complications. Viscoelastic methods (VEMs), including thrombelastography (TEG) and thromboelastometry (TEM), provide data on the nature of haemostatic disturbance. In this systematic review, we assessed the performance of TEG and TEM in the assessment of blood coagulation and fibrinolysis in patients with COVID-19. PubMed, Scopus, Web of Science Core Collection, medRxiv and bioRxiv were systematically searched for clinical studies eval...
Source: Thrombosis and Haemostasis - January 5, 2021 Category: Hematology Authors: Slomka A, Kowalewski M, Żekanowska E Tags: Thromb Haemost Source Type: research

A Comparative Study of Platelet Factor 4-Enhanced Platelet Activation Assays for the Diagnosis of Heparin-Induced Thrombocytopenia.
CONCLUSIONS: All PF4-enhanced assays demonstrated good performance characteristics when platelet donors were pre-selected. Further comparisons across multiple laboratories should be conducted for consensus on optimal HIT diagnostic testing. PMID: 33387395 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - January 2, 2021 Category: Hematology Authors: Rubino JG, Arnold DM, Warkentin TE, Smith JW, Kelton JG, Nazy I Tags: J Thromb Haemost Source Type: research

Obituary JW ten Cate.
i G Abstract Jan Wouter was born in Amsterdam and studied medicine at the University of Amsterdam, specialized in internal medicine, and defended his PhD thesis in 1971 with the subject 'Platelet functions in relation to haemostasis'. He became head of the department of thrombosis and hemostasis of the former Wilhelmina Gasthuis in Amsterdam, which later on, after the Academic Medical Center was formed, extended into the Centre for Thrombosis- Haemostasis-Atherosclerosis and Inflammation Research. In this fertile scientific environment, Jan Wouter, with his immense sense of humour, gift of speech and flamboyant pr...
Source: Thrombosis and Haemostasis - January 2, 2021 Category: Hematology Authors: Huisman MV, Levi M, van Royen E, Breederveld C, Büller H, Peters M, Sturk G, van Deventer S, Avvisati G, Prandoni P, Agnelli G Tags: J Thromb Haemost Source Type: research

Biological stratification of clinical disease courses in childhood immune thrombocytopenia.
CONCLUSIONS: The prediction of disease courses and IVIg treatment responses in ITP is improved by using both clinical and biological stratification. PMID: 33386662 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - January 1, 2021 Category: Hematology Authors: Schmidt DE, Heitink-Pollé KMJ, Mertens B, Porcelijn L, Kapur R, van der Schoot CE, Vidarsson G, van der Bom JG, Bruin MCA, de Haas M Tags: J Thromb Haemost Source Type: research

Application of a hemophilia mortality framework to the Emicizumab Global Safety Database.
CONCLUSIONS: No unique risk of death was associated with emicizumab prophylaxis in PwcHA. The data reveal that mortality in PwcHA receiving emicizumab was primarily associated with hemorrhage or non-HA-associated conditions, and was not reported by treaters to be related to emicizumab treatment. PMID: 33331041 [PubMed - in process] (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - December 19, 2020 Category: Hematology Authors: Peyvandi F, Mahlangu JN, Pipe SW, Hay CRM, Pierce GF, Kuebler P, Kruse-Jarres R, Shima M Tags: J Thromb Haemost Source Type: research

Establishment of a framework for assessing mortality in persons with congenital hemophilia A and its application to an adverse event reporting database.
CONCLUSIONS: A conceptual framework for examining mortality in PwcHA receiving any hemophilia therapy is proposed to analyze and interpret fatalities, enabling consistent and objective assessment. Application of the framework using FAERS data suggests a generally consistent pattern of reported mortality across HA treatments, supporting the utility of this unified approach. PMID: 33331042 [PubMed - in process] (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - December 19, 2020 Category: Hematology Authors: Pipe SW, Kruse-Jarres R, Mahlangu JN, Pierce GF, Peyvandi F, Kuebler P, De Ford C, Sanabria F, Ko RH, Chang T, Hay CRM Tags: J Thromb Haemost Source Type: research

Mortality in congenital hemophilia A  - a systematic literature review.
Mortality in congenital hemophilia A - a systematic literature review. J Thromb Haemost. 2021 Jan;19 Suppl 1:6-20 Authors: Hay CRM, Nissen F, Pipe SW Abstract Against a background of a rapidly evolving treatment landscape, a contemporary, evidence-based consolidated understanding of mortality in people with congenital hemophilia A (PwcHA) is lacking. This systematic literature review examines the available data on mortality and causes of death in PwcHA to enable a better understanding of fatalities in PwcHA and evaluate the impact of new treatment paradigms on mortality. A systematic literat...
Source: Thrombosis and Haemostasis - December 19, 2020 Category: Hematology Authors: Hay CRM, Nissen F, Pipe SW Tags: J Thromb Haemost Source Type: research

Safety first: Tracking adverse events associated with new therapies for people with hemophilia.
PMID: 33331044 [PubMed - in process] (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - December 19, 2020 Category: Hematology Authors: Recht M Tags: J Thromb Haemost Source Type: research

Monitoring of anticoagulation in thrombotic antiphospholipid syndrome.
Abstract Anticoagulation is central to the management of thrombotic antiphospholipid syndrome (APS). The standard anticoagulant treatment for thrombotic APS is life-long warfarin or an alternative vitamin K antagonist. The role of direct oral anticoagulants for thrombotic APS is not established due to the lack of definitive evidence and has recently been addressed in international guidance. Other anticoagulant options include low-molecular-weight heparin, unfractionated heparin and fondaparinux. In APS patients, lupus anticoagulant can affect phospholipid-dependent coagulation monitoring tests, so that they may no...
Source: Thrombosis and Haemostasis - December 16, 2020 Category: Hematology Authors: Cohen H, Efthymiou M, Devreese KMJ Tags: J Thromb Haemost Source Type: research

Risk of Thromboembolism in Patients with ALK and EGFR-Mutant Lung Cancer: A Cohort Study.
Abstract INTRODUCTION: Thromboembolism (TE) is common in patients with non-small cell lung cancer (NSCLC) and is associated with worse outcomes. Recent advances in the understanding of NSCLC have led to the identification of molecular subtypes such as ALK and EGFR mutations. The association of these subtypes with risk of TE has not been fully explored. METHODS: We conducted a retrospective cohort study of consecutive NSCLC patients seen at the Cleveland Clinic from July 2002 through July 2017 for whom molecular classification and follow-up were available. TE events included deep-vein thrombosis (DVT), pulmona...
Source: Thrombosis and Haemostasis - December 14, 2020 Category: Hematology Authors: Roopkumar J, Poudel SK, Gervaso L, Reddy CA, Velcheti V, Pennell NA, McCrae KR, Khorana AA Tags: J Thromb Haemost Source Type: research

High Thrombin Generation after Acute Ischemic Stroke or Transient Ischemic Attack Is Associated with a Reduced Risk of Recurrence: An Observational Cohort Study.
ska AC, Wallén H Abstract Thrombin is increasingly recognized to be of importance for cardiovascular disease. The aim of this study was to investigate the prognostic value of thrombin generation variables in a cohort of patients with acute ischemic stroke (AIS) or transient ischemic attack (TIA). Thrombin generation potential measured by calibrated automated thrombogram (CAT) and prothrombin fragment F1 + 2 was determined in the acute and convalescent phases for a cohort of 190 patients with AIS/TIA. Microvesicle (MV)-induced thrombin generation potential was determined for a subset of patient...
Source: Thrombosis and Haemostasis - December 12, 2020 Category: Hematology Authors: Lundström A, Änggårdh-Rooth E, Mobarrez F, Thålin C, Gigante B, Laska AC, Wallén H Tags: Thromb Haemost Source Type: research

New Rapid and Cost-Effective Tool for Monitoring DOACs.
PMID: 33314014 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - December 12, 2020 Category: Hematology Authors: Philippou H Tags: Thromb Haemost Source Type: research

Small Molecules: A Novel Approach to Alter Fibrinogen Production and Impact Venous Thrombosis.
PMID: 33314015 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - December 12, 2020 Category: Hematology Authors: Pieters M Tags: Thromb Haemost Source Type: research

Neutrophil extracellular traps enhance procoagulant activity in  patients with essential hypertension.
CONCLUSIONS: Our study revealed a previously unrecognized link between hypercoagulability and NETs in EH. Therefore, blocking NETs may represent a new therapeutic target for preventing thrombosis in these patients. PMID: 33314547 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - December 12, 2020 Category: Hematology Authors: Li J, Tong D, Wang Y, Liu Y, Zhang X, Liu N, Wang S, Xu Y, Li Y, Yin X, Liu W, Shao Y Tags: J Thromb Haemost Source Type: research

A novel vitamin K derived anticoagulant tolerant to genetic variations of vitamin K epoxide reductase.
CONCLUSION: We discovered a vitamin K analogue that functions as a VKA, and is tolerant to genetic variations in the target enzyme. PMID: 33314621 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - December 12, 2020 Category: Hematology Authors: Chen X, Liu Y, Furukawa N, Jin DY, Savage GP, Stafford DW, Suhara Y, Williams CM, Tie JK Tags: J Thromb Haemost Source Type: research

SARS-CoV-2 Associated Coagulopathy And Thromboembolism Prophylaxis In Children: A Single Centre Observational Study.
CONCLUSIONS: COVID-19 pediatric patients show mildly altered coagulation and inflammatory parameters; on the other hand, MIS-C cases show laboratory signs of an inflammatory driven pro-coagulant status. Universal anticoagulant prophylaxis in hospitalised children with SARS-CoV-2 related manifestations is not warranted, but may be offered to patients with other pro-thrombotic risk factors in the context of a multi-modal therapeutic approach. PMID: 33305475 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - December 11, 2020 Category: Hematology Authors: Del Borrello G, Giraudo I, Bondone C, Denina M, Garazzino S, Linari C, Mignone F, Pruccoli G, Scolfaro C, Spadea M, Pollio B, Saracco P Tags: J Thromb Haemost Source Type: research

Clinical history of cancer-associated splanchnic vein thrombosis.
CONCLUSIONS: The risk of recurrent thrombosis and bleeding appears to be similar in cancer patients with SVT and cancer patients with usual site VTE, despite some differences in baseline characteristics and anticoagulant treatment. Further prospective studies are warranted to confirm these findings. PMID: 33306241 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - December 11, 2020 Category: Hematology Authors: Valeriani E, Di Nisio M, Riva N, Caiano LM, Porreca E, Bang SM, Beyer-Westendorf J, Sartori MT, Barillari G, Santoro R, Kamphuisen PW, Alatri A, Malato A, Vidili G, Oh D, Schulman S, Ageno W, International Registry on Splanchnic Vein Thrombosis (IRSVT) st Tags: J Thromb Haemost Source Type: research

Should Emicizumab Be Used in Patients with Acquired Hemophilia A?
l P Abstract Emicizumab is currently approved to prevent bleeding in patients with congenital hemophilia A with or without neutralizing antibodies (inhibitors) against factor VIII (FVIII). Here, we present a case-based discussion of its potential use in acquired hemophilia A (AHA), a severe bleeding disorder caused by autoantibodies against FVIII. State-of-the-art management is based on bypassing agents (recombinant factor VIIa, activated prothrombin complex concentrate) and recombinant porcine FVIII; immunosuppressive therapy (corticosteroids, rituximab, cyclophosphamide) is used to suppress autoantibody formatio...
Source: Thrombosis and Haemostasis - December 11, 2020 Category: Hematology Authors: Tiede A, Kemkes-Matthes B, Knöbl P Tags: J Thromb Haemost Source Type: research

Embolic stroke of undetermined source: The need for an integrated and holistic approach to care.
Abstract No Abstract. PMID: 33307563 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - December 11, 2020 Category: Hematology Authors: Guo Y, Zhang J, Lip GY Tags: Thromb Haemost Source Type: research

Polyanions in Coagulation and Thrombosis: Focus on Polyphosphate and NETs.
te; T Abstract Neutrophils extracellular traps (NETs) and polyphosphates (polyP) have been recognized as procoagulant polyanions. The review summarizes the activities and regulation of two procoagulant mediators and compares their functions. NETs are composed of DNA and share a phosphate backbone with polyP that is built of phosphate units linked by high energy phospho-anhydride bonds. Both NETs and polyP form insoluble particulate surfaces composed of a DNA/histone meshwork or Ca2+-rich nanoparticles, respectively. The polyanions modulate coagulation involving an array of mechanisms and trigger thrombosis via act...
Source: Thrombosis and Haemostasis - December 11, 2020 Category: Hematology Authors: Rangaswamy C, Englert H, Deppermann C, Renné T Tags: Thromb Haemost Source Type: research

Age-dependent anticoagulant therapy for atrial fibrillation patients with intermediate risk of ischemic stroke: A nationwide population-based study.
CONCLUSIONS: Age is an important determinant of ischemic stroke and composite outcome in intermediate-risk AF patients. The benefit of OAC therapy for these AF patients appears to have an age threshold (age ≥ 55 years). PMID: 33307565 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - December 11, 2020 Category: Hematology Authors: Choi SY, Kim MHH, Lee KM, Cho YR, Park JS, Yun SC, Lip GY Tags: Thromb Haemost Source Type: research

Gray platelet syndrome: NBEAL2 mutations are associated with pathology beyond megakaryocyte and platelet function defects.
PMID: 33300270 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - December 10, 2020 Category: Hematology Authors: Pluthero FG, Kahr WHA Tags: J Thromb Haemost Source Type: research

Cellular Fibronectin Promotes Deep Vein Thrombosis in Diet-induced Obese Mice.
CONCLUSION: These results demonstrate a previously unknown role of Fn-EDA in the DVT exacerbation, which may be an essential mechanism promoting DVT in the setting of diet-induced obesity. PMID: 33300307 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - December 10, 2020 Category: Hematology Authors: Dhanesha N, Jain M, Doddapattar P, Undas A, Chauhan AK Tags: J Thromb Haemost Source Type: research