Hematuria in anticoagulated patients with atrial fibrillation and urologic cancer
CONCLUSION: In patients with AF and urologic cancer, there was a similar risk of hematuria associated with DOAC and warfarin treatment.PMID:35059549 | PMC:PMC8756162 | DOI:10.1002/rth2.12629 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - January 21, 2022 Category: Hematology Authors: Anne Gulbech Ording Mette S øgaard Flemming Skj øth Erik Lerkevang Grove Gregory Y H Lip Torben Bjerregaard Larsen Peter Br ønnum Nielsen Source Type: research

Embolism-The journey from a calendar to the clot via the Lord's prayer
J Thromb Haemost. 2022 Feb;20(2):538-539. doi: 10.1111/jth.15610.NO ABSTRACTPMID:35060302 | DOI:10.1111/jth.15610 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - January 21, 2022 Category: Hematology Authors: Jecko Thachil Source Type: research

Vaccine-induced immune thrombotic thrombocytopenia: Update on diagnosis and management considering different resources: Comment from Yamada et al
J Thromb Haemost. 2022 Feb;20(2):540-541. doi: 10.1111/jth.15618.NO ABSTRACTPMID:35060303 | DOI:10.1111/jth.15618 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - January 21, 2022 Category: Hematology Authors: Shinya Yamada Hidesaku Asakura Source Type: research

Vaccine-induced immune thrombotic thrombocytopenia (VITT) - update on diagnosis and management considering different resources: Response to Comment from Yamada et al
J Thromb Haemost. 2022 Feb;20(2):542-543. doi: 10.1111/jth.15619.NO ABSTRACTPMID:35060304 | DOI:10.1111/jth.15619 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - January 21, 2022 Category: Hematology Authors: Andreas Greinacher Florian Langer Mike Makris Menaka Pai Sue Pavord Huyen Tran Theodore E Warkentin Source Type: research

Multiplex protein screening of biomarkers associated with major bleeding in patients with atrial fibrillation treated with oral anticoagulation: Comment from Luo et al
J Thromb Haemost. 2022 Feb;20(2):536-537. doi: 10.1111/jth.15603.NO ABSTRACTPMID:35060305 | DOI:10.1111/jth.15603 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - January 21, 2022 Category: Hematology Authors: Fanyan Luo Haisong Bu Source Type: research

Multiplex protein screening of biomarkers associated with major bleeding in patients with atrial fibrillation treated with oral anticoagulation: Response to Luo and Bu
J Thromb Haemost. 2022 Feb;20(2):537. doi: 10.1111/jth.15601.NO ABSTRACTPMID:35060306 | DOI:10.1111/jth.15601 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - January 21, 2022 Category: Hematology Authors: Agneta Siegbahn Source Type: research

What the neighbors say
J Thromb Haemost. 2022 Feb;20(2):279. doi: 10.1111/jth.15629.NO ABSTRACTPMID:35060307 | DOI:10.1111/jth.15629 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - January 21, 2022 Category: Hematology Source Type: research

TaSER: Combining forces to stop the clot
J Thromb Haemost. 2022 Feb;20(2):293-295. doi: 10.1111/jth.15597.NO ABSTRACTPMID:35060308 | DOI:10.1111/jth.15597 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - January 21, 2022 Category: Hematology Authors: C écile V Denis Peter J Lenting Denis Wahl Source Type: research

Novel GNE Gene Variants Associated with Severe Congenital Thrombocytopenia and Platelet Sialylation Defect
Thromb Haemost. 2022 Jan 20. doi: 10.1055/s-0041-1742207. Online ahead of print.ABSTRACTThe GNE gene encodes an enzyme that initiates and regulates the biosynthesis of N-acetylneuraminic acid, a precursor of sialic acids. GNE mutations are classically associated with Nonaka myopathy and sialuria, following an autosomal recessive and autosomal dominant inheritance pattern. Reports show that single GNE variants cause severe thrombocytopenia without muscle weakness. Using panel sequencing, we identified two novel compound heterozygous variants in GNE in a young girl with life-threatening bleedings, severe congenital thrombocy...
Source: Thrombosis and Haemostasis - January 20, 2022 Category: Hematology Authors: Barbara Zieger Doris Boeckelmann Waseem Anani Herv é Falet Jieqing Zhu Hannah Glonnegger Hermann Full Felicia Andresen Miriam Erlacher Ekkehart Lausch Salome Fels Brigitte Strahm Peter Lang Karin M Hoffmeister Source Type: research

Aspirin for Primary and Secondary Prevention of Cardiovascular Disease: Time to Stop?
Thromb Haemost. 2022 Jan 20. doi: 10.1055/s-0041-1740639. Online ahead of print.NO ABSTRACTPMID:35052007 | DOI:10.1055/s-0041-1740639 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - January 20, 2022 Category: Hematology Authors: John G F Cleland Source Type: research

A Meta-Analysis of Plasma Homocysteine in Buerger's Disease
Thromb Haemost. 2022 Jan 20. doi: 10.1055/s-0041-1742165. Online ahead of print.NO ABSTRACTPMID:35052008 | DOI:10.1055/s-0041-1742165 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - January 20, 2022 Category: Hematology Authors: Mira Merashli Tommaso Bucci Daniele Pastori Pasquale Pignatelli Alessia Arcaro Fabrizio Gentile Vincenzo Marottoli Paul R J Ames Source Type: research

Impact of fibrinogen infusion on thrombin generation and fibrin clot structure in patients with inherited afibrinogenemia
Thromb Haemost. 2022 Jan 19. doi: 10.1055/a-1745-0420. Online ahead of print.ABSTRACTINTRODUCTION: Inherited afibrinogenemia is a very rare disease characterized by complete absence of fibrinogen in the circulation and an increased risk in both thrombosis and bleeding. Infusion of fibrinogen concentrate (FC) is the main approach for prevention and management of bleeding; however, it has been reported to carry a thrombotic risk.METHODS: We investigated the impact of a standard dose (40-100 mg/kg) of FC infusion on the thrombin generation (TG) parameters and the fibrin clot structure formed in plasma samples of patients with...
Source: Thrombosis and Haemostasis - January 19, 2022 Category: Hematology Authors: Claudia Djambas Khayat Rita Marchi St éphane Durual Thomas Lecompte Marguerite Neerman-Arbez Alessandro Casini Source Type: research

Stroke and Thromboembolism in Patients with Heart Failure and Sinus Rhythm: A Matter of Risk Stratification?
Thromb Haemost. 2022 Jan 19. doi: 10.1055/a-1745-2083. Online ahead of print.ABSTRACTPatients with heart failure (HF) in sinus rhythm (SR) experience an increased incidence of thromboembolic events including stroke. Among patients with HF, high-quality evidence supports the use of oral anticoagulation when atrial fibrillation (AF) is present, but the benefit of anticoagulation in SR in absence of other known indications for anticoagulation is unclear. In four randomized controlled trials (RCTs), warfarin did not improve a composite of clinical outcomes compared with aspirin or placebo in patients with HF with reduced eject...
Source: Thrombosis and Haemostasis - January 19, 2022 Category: Hematology Authors: Angelica Rivas Mandy N Lauw Renate Bonin-Schnabel Mark Crowther Harriette Van Spall Source Type: research

Impact of fibrinogen infusion on thrombin generation and fibrin clot structure in patients with inherited afibrinogenemia
Thromb Haemost. 2022 Jan 19. doi: 10.1055/a-1745-0420. Online ahead of print.ABSTRACTINTRODUCTION: Inherited afibrinogenemia is a very rare disease characterized by complete absence of fibrinogen in the circulation and an increased risk in both thrombosis and bleeding. Infusion of fibrinogen concentrate (FC) is the main approach for prevention and management of bleeding; however, it has been reported to carry a thrombotic risk.METHODS: We investigated the impact of a standard dose (40-100 mg/kg) of FC infusion on the thrombin generation (TG) parameters and the fibrin clot structure formed in plasma samples of patients with...
Source: Thrombosis and Haemostasis - January 19, 2022 Category: Hematology Authors: Claudia Djambas Khayat Rita Marchi St éphane Durual Thomas Lecompte Marguerite Neerman-Arbez Alessandro Casini Source Type: research

Stroke and Thromboembolism in Patients with Heart Failure and Sinus Rhythm: A Matter of Risk Stratification?
Thromb Haemost. 2022 Jan 19. doi: 10.1055/a-1745-2083. Online ahead of print.ABSTRACTPatients with heart failure (HF) in sinus rhythm (SR) experience an increased incidence of thromboembolic events including stroke. Among patients with HF, high-quality evidence supports the use of oral anticoagulation when atrial fibrillation (AF) is present, but the benefit of anticoagulation in SR in absence of other known indications for anticoagulation is unclear. In four randomized controlled trials (RCTs), warfarin did not improve a composite of clinical outcomes compared with aspirin or placebo in patients with HF with reduced eject...
Source: Thrombosis and Haemostasis - January 19, 2022 Category: Hematology Authors: Angelica Rivas Mandy N Lauw Renate Bonin-Schnabel Mark Crowther Harriette Van Spall Source Type: research

Effectiveness and safety of direct oral anticoagulants with antiplatelet agents in patients with venous thromboembolism: A multi-database cohort study
CONCLUSIONS: Among patients with VTE using antiplatelets, there were no major differences in effectiveness and safety between DOACs and VKAs.PMID:35036824 | PMC:PMC8749078 | DOI:10.1002/rth2.12643 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - January 17, 2022 Category: Hematology Authors: Antonios Douros Frederike Basedow Ying Cui Jochen Walker Dirk Enders Vicky Tagalakis Source Type: research

Reliable measurement of plasma kinin peptides: Importance of preanalytical variables
CONCLUSION: The developed procedure for blood specimen collection and handling is feasible in clinical settings and allows for determination of reliable kinin levels. It may contribute to further elucidating the role of the kallikrein-kinin system in diseases like angioedema, sepsis, or coronavirus disease 2019.PMID:35036825 | PMC:PMC8753134 | DOI:10.1002/rth2.12646 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - January 17, 2022 Category: Hematology Authors: Tanja Gangnus Bjoern B Burckhardt Source Type: research

Alpha-2-macroglobulin in hemostasis and thrombosis: an underestimated old double-edged sword
J Thromb Haemost. 2022 Jan 17. doi: 10.1111/jth.15647. Online ahead of print.ABSTRACTAntiproteinases such as alpha-2-macroglobulin (A2M) play a role in hemostasis. A2M is highly conserved throughout evolution and is a high molecular weight homo-tetrameric glycoprotein. A2M proteinase inhibitor activity is possible via a unique cage structure leading to proteinase entrapment without direct enzymatic activity inhibition. Following this entrapment, proteinase clearance is possible through A2M binding to the low-density lipoprotein receptor-related protein 1: LRP1. A2M synthesis is regulated by pro-inflammatory cytokines and i...
Source: Thrombosis and Haemostasis - January 17, 2022 Category: Hematology Authors: Jeremy Lagrange Thomas Lecompte Tanja Knopp Patrick Lacolley V éronique Regnault Source Type: research

Thrombin in complex with dabigatran can still interact with PAR-1 via exosite-I and instigate loss of vascular integrity
CONCLUSIONS: Proteolytically inactive thrombin in complex with dabigatran evokes loss of barrier function that can be prevented by a PAR-1 mimicking peptide blocking thrombin's exosite-I.PMID:35037739 | DOI:10.1111/jth.15642 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - January 17, 2022 Category: Hematology Authors: Sophie C D ólleman Stijn M Agten Henri M H Spronk Tilman M Hackeng Mettine H A Bos Henri H Versteeg Anton Jan van Zonneveld Hetty C de Boer Source Type: research

A Rollercoaster Plunge into 2022
Thromb Haemost. 2022 Jan;122(1):1-4. doi: 10.1055/s-0041-1741073. Epub 2022 Jan 17.NO ABSTRACTPMID:35038759 | DOI:10.1055/s-0041-1741073 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - January 17, 2022 Category: Hematology Authors: Gregory Y H Lip Anne Rigby Christian Weber Source Type: research

Thrombosis and Haemostasis 2021 Editors' Choice Papers
Thromb Haemost. 2022 Jan;122(1):163-170. doi: 10.1055/s-0041-1741072. Epub 2022 Jan 17.NO ABSTRACTPMID:35038760 | DOI:10.1055/s-0041-1741072 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - January 17, 2022 Category: Hematology Authors: Christian Weber Anne Rigby Gregory Y H Lip Source Type: research

RARE CAUSES OF ACUTE CORONARY SYNDROME: THE JAK2 V617F MUTATION POSITIVE MYELOPROLIFERATIVE NEOPLASMS. A cardio-hematological perspective
Thromb Haemost. 2022 Jan 17. doi: 10.1055/a-1742-0361. Online ahead of print.ABSTRACTN/A.PMID:35038762 | DOI:10.1055/a-1742-0361 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - January 17, 2022 Category: Hematology Authors: Silvia Cantoni Claudia Colombo Francesco Soriano Jacopo A Oreglia Alice Sacco Silvio Veronese Dario Brunelli Andrea Rubboli Nuccia Morici Source Type: research

Incidence and Outcomes Associated with 6841 Isolated Distal Deep Vein Thromboses in Patients with 13 Common Cancers
CONCLUSION: iDDVT represented 11% of CAT. The risk of rVTE after iDDVT was similar to other sites of CAT and rVTE occurred in more proximal locations after an incident iDDVT. IDDVT was associated with increased mortality and this effect was similar to that of PE or pDVT for most cancer types.PMID:35038763 | DOI:10.1055/a-1742-0177 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - January 17, 2022 Category: Hematology Authors: Anjlee Mahajan Ann Brunson Joanna Eldredge Richard H White Theresa Keegan Ted Wun Source Type: research

Measurement of procoagulant platelets provides mechanistic insight and diagnostic potential in heparin-induced thrombocytopenia
CONCLUSIONS: We demonstrate that HIT plasma together with platelet agonists increased the procoagulant platelet proportions which may contribute to thrombotic risk in HIT. Targeting procoagulant platelet activation may represent a novel treatment strategy. This assay may be a rapid, clinically relevant functional assay for accurately detecting pathological HIT antibodies.PMID:35038779 | DOI:10.1111/jth.15650 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - January 17, 2022 Category: Hematology Authors: Christine S M Lee Maria V Selvadurai Leonardo Pasalic James Yeung Maria Konda Geoffrey W Kershaw Emmanuel J Favaloro Vivien M Chen Source Type: research

Treatment of patients with rare bleeding disorders in the Netherlands: Real-life data from the RBiN study
CONCLUSION: Large heterogeneity in general treatment plans of RBD patients was found. Bleeding after invasive procedures was reported frequently, both before and after RBD diagnosis, irrespective of factor activity levels and particularly when peri-procedural treatment was omitted. Improved guidelines should include uniform recommendations for most appropriate hemostatic products per RBD and emphasize the relevance of individual bleeding history.PMID:35038781 | DOI:10.1111/jth.15652 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - January 17, 2022 Category: Hematology Authors: Dominique P M S M Maas Joline L Saes Nicole M A Blijlevens Marjon H Cnossen Paul L den Exter Ilmar C Kruis Karina Meijer Laurens Nieuwenhuizen Marjolein Peters Roger E G Schutgens Waander L van Heerde Saskia E M Schols RBiN study group Source Type: research

Obituary for Stefano Duga (1967-2021): a life for science
J Thromb Haemost. 2022 Jan 17. doi: 10.1111/jth.15651. Online ahead of print.NO ABSTRACTPMID:35038784 | DOI:10.1111/jth.15651 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - January 17, 2022 Category: Hematology Authors: Rosanna Asselta Domenico Girelli Flora Peyvandi Source Type: research

Effectiveness and safety of direct oral anticoagulants with antiplatelet agents in patients with venous thromboembolism: A multi-database cohort study
CONCLUSIONS: Among patients with VTE using antiplatelets, there were no major differences in effectiveness and safety between DOACs and VKAs.PMID:35036824 | PMC:PMC8749078 | DOI:10.1002/rth2.12643 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - January 17, 2022 Category: Hematology Authors: Antonios Douros Frederike Basedow Ying Cui Jochen Walker Dirk Enders Vicky Tagalakis Source Type: research

Reliable measurement of plasma kinin peptides: Importance of preanalytical variables
CONCLUSION: The developed procedure for blood specimen collection and handling is feasible in clinical settings and allows for determination of reliable kinin levels. It may contribute to further elucidating the role of the kallikrein-kinin system in diseases like angioedema, sepsis, or coronavirus disease 2019.PMID:35036825 | PMC:PMC8753134 | DOI:10.1002/rth2.12646 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - January 17, 2022 Category: Hematology Authors: Tanja Gangnus Bjoern B Burckhardt Source Type: research

Alpha-2-macroglobulin in hemostasis and thrombosis: an underestimated old double-edged sword
J Thromb Haemost. 2022 Jan 17. doi: 10.1111/jth.15647. Online ahead of print.ABSTRACTAntiproteinases such as alpha-2-macroglobulin (A2M) play a role in hemostasis. A2M is highly conserved throughout evolution and is a high molecular weight homo-tetrameric glycoprotein. A2M proteinase inhibitor activity is possible via a unique cage structure leading to proteinase entrapment without direct enzymatic activity inhibition. Following this entrapment, proteinase clearance is possible through A2M binding to the low-density lipoprotein receptor-related protein 1: LRP1. A2M synthesis is regulated by pro-inflammatory cytokines and i...
Source: Thrombosis and Haemostasis - January 17, 2022 Category: Hematology Authors: Jeremy Lagrange Thomas Lecompte Tanja Knopp Patrick Lacolley V éronique Regnault Source Type: research

Thrombin in complex with dabigatran can still interact with PAR-1 via exosite-I and instigate loss of vascular integrity
CONCLUSIONS: Proteolytically inactive thrombin in complex with dabigatran evokes loss of barrier function that can be prevented by a PAR-1 mimicking peptide blocking thrombin's exosite-I.PMID:35037739 | DOI:10.1111/jth.15642 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - January 17, 2022 Category: Hematology Authors: Sophie C D ólleman Stijn M Agten Henri M H Spronk Tilman M Hackeng Mettine H A Bos Henri H Versteeg Anton Jan van Zonneveld Hetty C de Boer Source Type: research

A Rollercoaster Plunge into 2022
Thromb Haemost. 2022 Jan;122(1):1-4. doi: 10.1055/s-0041-1741073. Epub 2022 Jan 17.NO ABSTRACTPMID:35038759 | DOI:10.1055/s-0041-1741073 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - January 17, 2022 Category: Hematology Authors: Gregory Y H Lip Anne Rigby Christian Weber Source Type: research

Thrombosis and Haemostasis 2021 Editors' Choice Papers
Thromb Haemost. 2022 Jan;122(1):163-170. doi: 10.1055/s-0041-1741072. Epub 2022 Jan 17.NO ABSTRACTPMID:35038760 | DOI:10.1055/s-0041-1741072 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - January 17, 2022 Category: Hematology Authors: Christian Weber Anne Rigby Gregory Y H Lip Source Type: research

RARE CAUSES OF ACUTE CORONARY SYNDROME: THE JAK2 V617F MUTATION POSITIVE MYELOPROLIFERATIVE NEOPLASMS. A cardio-hematological perspective
Thromb Haemost. 2022 Jan 17. doi: 10.1055/a-1742-0361. Online ahead of print.ABSTRACTN/A.PMID:35038762 | DOI:10.1055/a-1742-0361 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - January 17, 2022 Category: Hematology Authors: Silvia Cantoni Claudia Colombo Francesco Soriano Jacopo A Oreglia Alice Sacco Silvio Veronese Dario Brunelli Andrea Rubboli Nuccia Morici Source Type: research

Incidence and Outcomes Associated with 6841 Isolated Distal Deep Vein Thromboses in Patients with 13 Common Cancers
CONCLUSION: iDDVT represented 11% of CAT. The risk of rVTE after iDDVT was similar to other sites of CAT and rVTE occurred in more proximal locations after an incident iDDVT. IDDVT was associated with increased mortality and this effect was similar to that of PE or pDVT for most cancer types.PMID:35038763 | DOI:10.1055/a-1742-0177 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - January 17, 2022 Category: Hematology Authors: Anjlee Mahajan Ann Brunson Joanna Eldredge Richard H White Theresa Keegan Ted Wun Source Type: research

Measurement of procoagulant platelets provides mechanistic insight and diagnostic potential in heparin-induced thrombocytopenia
CONCLUSIONS: We demonstrate that HIT plasma together with platelet agonists increased the procoagulant platelet proportions which may contribute to thrombotic risk in HIT. Targeting procoagulant platelet activation may represent a novel treatment strategy. This assay may be a rapid, clinically relevant functional assay for accurately detecting pathological HIT antibodies.PMID:35038779 | DOI:10.1111/jth.15650 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - January 17, 2022 Category: Hematology Authors: Christine S M Lee Maria V Selvadurai Leonardo Pasalic James Yeung Maria Konda Geoffrey W Kershaw Emmanuel J Favaloro Vivien M Chen Source Type: research

Treatment of patients with rare bleeding disorders in the Netherlands: Real-life data from the RBiN study
CONCLUSION: Large heterogeneity in general treatment plans of RBD patients was found. Bleeding after invasive procedures was reported frequently, both before and after RBD diagnosis, irrespective of factor activity levels and particularly when peri-procedural treatment was omitted. Improved guidelines should include uniform recommendations for most appropriate hemostatic products per RBD and emphasize the relevance of individual bleeding history.PMID:35038781 | DOI:10.1111/jth.15652 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - January 17, 2022 Category: Hematology Authors: Dominique P M S M Maas Joline L Saes Nicole M A Blijlevens Marjon H Cnossen Paul L den Exter Ilmar C Kruis Karina Meijer Laurens Nieuwenhuizen Marjolein Peters Roger E G Schutgens Waander L van Heerde Saskia E M Schols RBiN study group Source Type: research

Obituary for Stefano Duga (1967-2021): a life for science
J Thromb Haemost. 2022 Jan 17. doi: 10.1111/jth.15651. Online ahead of print.NO ABSTRACTPMID:35038784 | DOI:10.1111/jth.15651 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - January 17, 2022 Category: Hematology Authors: Rosanna Asselta Domenico Girelli Flora Peyvandi Source Type: research

Effectiveness and safety of direct oral anticoagulants with antiplatelet agents in patients with venous thromboembolism: A multi-database cohort study
CONCLUSIONS: Among patients with VTE using antiplatelets, there were no major differences in effectiveness and safety between DOACs and VKAs.PMID:35036824 | PMC:PMC8749078 | DOI:10.1002/rth2.12643 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - January 17, 2022 Category: Hematology Authors: Antonios Douros Frederike Basedow Ying Cui Jochen Walker Dirk Enders Vicky Tagalakis Source Type: research

Reliable measurement of plasma kinin peptides: Importance of preanalytical variables
CONCLUSION: The developed procedure for blood specimen collection and handling is feasible in clinical settings and allows for determination of reliable kinin levels. It may contribute to further elucidating the role of the kallikrein-kinin system in diseases like angioedema, sepsis, or coronavirus disease 2019.PMID:35036825 | PMC:PMC8753134 | DOI:10.1002/rth2.12646 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - January 17, 2022 Category: Hematology Authors: Tanja Gangnus Bjoern B Burckhardt Source Type: research

Alpha-2-macroglobulin in hemostasis and thrombosis: an underestimated old double-edged sword
J Thromb Haemost. 2022 Jan 17. doi: 10.1111/jth.15647. Online ahead of print.ABSTRACTAntiproteinases such as alpha-2-macroglobulin (A2M) play a role in hemostasis. A2M is highly conserved throughout evolution and is a high molecular weight homo-tetrameric glycoprotein. A2M proteinase inhibitor activity is possible via a unique cage structure leading to proteinase entrapment without direct enzymatic activity inhibition. Following this entrapment, proteinase clearance is possible through A2M binding to the low-density lipoprotein receptor-related protein 1: LRP1. A2M synthesis is regulated by pro-inflammatory cytokines and i...
Source: Thrombosis and Haemostasis - January 17, 2022 Category: Hematology Authors: Jeremy Lagrange Thomas Lecompte Tanja Knopp Patrick Lacolley V éronique Regnault Source Type: research

Thrombin in complex with dabigatran can still interact with PAR-1 via exosite-I and instigate loss of vascular integrity
CONCLUSIONS: Proteolytically inactive thrombin in complex with dabigatran evokes loss of barrier function that can be prevented by a PAR-1 mimicking peptide blocking thrombin's exosite-I.PMID:35037739 | DOI:10.1111/jth.15642 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - January 17, 2022 Category: Hematology Authors: Sophie C D ólleman Stijn M Agten Henri M H Spronk Tilman M Hackeng Mettine H A Bos Henri H Versteeg Anton Jan van Zonneveld Hetty C de Boer Source Type: research

Thrombin generation for monitoring hemostatic therapy in hemophilia A: a narrative review
J Thromb Haemost. 2022 Jan 16. doi: 10.1111/jth.15640. Online ahead of print.ABSTRACTPatients with severe hemophilia A (HA) have an increased risk of spontaneous and trauma-related bleeding due to a congenital absence of factor VIII (FVIII). Most severe HA patients use prophylactic FVIII concentrate which effect can be monitored with FVIII activity level measurement. However, FVIII activity level is less valuable in predicting the potential clinical bleeding risk. Some patients still experience breakthrough bleeds despite adequate FVIII trough levels, while others do not bleed with trough levels below threshold. This diffe...
Source: Thrombosis and Haemostasis - January 16, 2022 Category: Hematology Authors: Marieke J A Verhagen Lars L F G Valke Saskia E M Schols Source Type: research

Maintaining flippase activity in procoagulant platelets is a novel approach to reducing thrombin generation
CONCLUSIONS: R5421 reduced the extent of A23187-stimulated platelet PS exposure, as demonstrated with annexin V or lactadherin binding. R5421 also maintained flippase activity in procoagulant platelets. Although R5421 appeared to inhibit scramblase activity in procoagulant platelets, it did not once the flippase had been inhibited, demonstrating that scramblase activity is not directly inhibited. Furthermore, R5421 inhibited the contribution of A23187-stimulated platelets to thrombin generation. Together these data demonstrate that R5421 reduces the extent of PS exposure in procoagulant platelets by maintaining flippase ac...
Source: Thrombosis and Haemostasis - January 16, 2022 Category: Hematology Authors: Sarah L Millington-Burgess Matthew T Harper Source Type: research

Platelet and immune signature associated with a rapid response to the BNT162b2 mRNA Covid-19 Vaccine
CONCLUSION: We identified features of the platelet-immune crosstalk that are associated with the development of a rapid humoral response to an mRNA-based vaccine (BNT162b2) and that could be exploited as early biomarkers of vaccine efficacy.PMID:35032087 | DOI:10.1111/jth.15648 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - January 15, 2022 Category: Hematology Authors: Davide Flego Simone Cesaroni Giulio F Romiti Bernadette Corica Ramona Marrapodi Noemi Scafa Francesca Maiorca Ludovica Lombardi Davide Pallucci Fabio Pulcinelli Valeria Raparelli Marcella Visentini Roberto Cangemi Silvia Piconese Domenico Alvaro Antonella Source Type: research

Impact of COVID-19 on thrombus composition and response to thrombolysis: Insights from a monocentric cohort population of COVID-19 patients with acute ischemic stroke
CONCLUSIONS: These results show that COVID-19 does not impact NETs content or worsen fibrinolysis resistance of AIS thrombi, a therapeutic hurdle that could be overcome by DNase 1 even in the context of SARS-Cov-2 infection.PMID:35032088 | DOI:10.1111/jth.15646 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - January 15, 2022 Category: Hematology Authors: Jean-Philippe Desilles Mialitiana Solo Nomenjanahary Arturo Consoli V éronique Ollivier Doroth ée Faille Marie-Charlotte Bourrienne Myl ène Hamdani S ébastien Dupont Lucas Di Meglio Simon Escalard Benjamin Maier Raphael Blanc Michel Piotin Bertrand La Source Type: research

Platelet and immune signature associated with a rapid response to the BNT162b2 mRNA Covid-19 Vaccine
CONCLUSION: We identified features of the platelet-immune crosstalk that are associated with the development of a rapid humoral response to an mRNA-based vaccine (BNT162b2) and that could be exploited as early biomarkers of vaccine efficacy.PMID:35032087 | DOI:10.1111/jth.15648 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - January 15, 2022 Category: Hematology Authors: Davide Flego Simone Cesaroni Giulio F Romiti Bernadette Corica Ramona Marrapodi Noemi Scafa Francesca Maiorca Ludovica Lombardi Davide Pallucci Fabio Pulcinelli Valeria Raparelli Marcella Visentini Roberto Cangemi Silvia Piconese Domenico Alvaro Antonella Source Type: research

Impact of COVID-19 on thrombus composition and response to thrombolysis: Insights from a monocentric cohort population of COVID-19 patients with acute ischemic stroke
CONCLUSIONS: These results show that COVID-19 does not impact NETs content or worsen fibrinolysis resistance of AIS thrombi, a therapeutic hurdle that could be overcome by DNase 1 even in the context of SARS-Cov-2 infection.PMID:35032088 | DOI:10.1111/jth.15646 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - January 15, 2022 Category: Hematology Authors: Jean-Philippe Desilles Mialitiana Solo Nomenjanahary Arturo Consoli V éronique Ollivier Doroth ée Faille Marie-Charlotte Bourrienne Myl ène Hamdani S ébastien Dupont Lucas Di Meglio Simon Escalard Benjamin Maier Raphael Blanc Michel Piotin Bertrand La Source Type: research

Evaluation of the Khorana score for prediction of venous thromboembolism in patients with multiple myeloma
CONCLUSIONS: In conclusion, in this cohort of 2870 patients with MM, the Khorana score did not predict VTE. Our study supports the need to use myeloma-specific risk models to predict VTE risk in patients with MM.PMID:35028491 | PMC:PMC8742966 | DOI:10.1002/rth2.12634 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - January 14, 2022 Category: Hematology Authors: Kristen M Sanfilippo Kenneth R Carson Tzu-Fei Wang Suhong Luo Natasha Edwin Nicole Kuderer Jesse M Keller Brian F Gage Source Type: research

Evaluation of the Khorana score for prediction of venous thromboembolism in patients with multiple myeloma
CONCLUSIONS: In conclusion, in this cohort of 2870 patients with MM, the Khorana score did not predict VTE. Our study supports the need to use myeloma-specific risk models to predict VTE risk in patients with MM.PMID:35028491 | PMC:PMC8742966 | DOI:10.1002/rth2.12634 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - January 14, 2022 Category: Hematology Authors: Kristen M Sanfilippo Kenneth R Carson Tzu-Fei Wang Suhong Luo Natasha Edwin Nicole Kuderer Jesse M Keller Brian F Gage Source Type: research

Factor XI as a target for preventing venous thromboembolism
J Thromb Haemost. 2022 Jan 12. doi: 10.1111/jth.15628. Online ahead of print.NO ABSTRACTPMID:35023278 | DOI:10.1111/jth.15628 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - January 13, 2022 Category: Hematology Authors: David Gailani Source Type: research