Long Noncoding RNAs of the Arterial Wall as Therapeutic Agents and Targets in Atherosclerosis.
Abstract Long noncoding ribonucleic acids (lncRNAs) have been defined as transcripts which are > 200 ribonucleotides in size and are not translated into protein. Recent work has shown that many lncRNAs do have specific molecular functions and biological effects, and are involved in a growing number of diseases, including atherosclerosis. As a consequence, lncRNAs are also becoming interesting targets for therapeutic intervention. Here, we focus on lncRNAs which are expressed in the arterial wall, and describe potential RNA therapeutic approaches of atherosclerosis by manipulating lncRNAs without a...
Source: Thrombosis and Haemostasis - July 16, 2019 Category: Hematology Authors: Holdt LM, Kohlmaier A, Teupser D Tags: Thromb Haemost Source Type: research

Heparin-induced thrombocytopenia complicating extracorporeal membrane oxygenation support: Review of the literature and alternative anticoagulants.
This article is protected by copyright. All rights reserved. PMID: 31313454 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - July 16, 2019 Category: Hematology Authors: Pollak U Tags: J Thromb Haemost Source Type: research

Purification of silica-free DNA and characterization of its role in coagulation.
CONCLUSIONS: Unlike the isolated DNA, commercially available calf thymus DNA contains thrombin-like amydolytic activity. PAX-DNA and DBL-DNA did not contain silica nor functionally detectable polyP as contaminants. Both PAX- and DBL-DNA were procoagulant in a dose-dependent manner, which is neutralized with DNase I. Thus, we recommend the use of PAX-DNA or DBL-DNA for functional studies to investigate the role of extracellular DNA. This article is protected by copyright. All rights reserved. PMID: 31309685 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - July 15, 2019 Category: Hematology Authors: Medeiros SK, Zafar N, Liaw PC, Kim PY Tags: J Thromb Haemost Source Type: research

Arterial and venous thrombosis by high platelet count and high hematocrit: 108,521 individuals from the Copenhagen General Population Study.
CONCLUSION: Multivariable adjusted hazard ratios for individuals with platelet counts in the top 5 percentiles (>398 x 109 /L) versus in the 25th -75th percentiles (231-316x 109 /L) were 1.77 (95% CI: 1.38-2.24) for arterial thrombosis in the brain (38 and 26 events/10,000 person-years) and 0.82 (0.61-1.11) for arterial thrombosis in the heart (23 and 28 events/10,000 person-years). For individuals with hematocrit values in the top 5 percentiles (women/men:> 45 /> 48%) versus the 25th -75th percentiles (women/men: 38.1-42 / 41.1-45%), hazard ratios were 1.27 (0.91-1.75) for arterial thrombosis in the brain (40 and...
Source: Thrombosis and Haemostasis - July 15, 2019 Category: Hematology Authors: Warny M, Helby J, Birgens HS, Bojesen SE, Nordestgaard BG Tags: J Thromb Haemost Source Type: research

Prevalence of postpartum venous thromboembolism risk factors in an Irish urban obstetric population.
CONCLUSION: This study demonstrates the high prevalence of VTE risk factors among postpartum women. Postpartum VTE risk is highly individualized and complex. This article is protected by copyright. All rights reserved. PMID: 31309719 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - July 15, 2019 Category: Hematology Authors: O'Shaughnessy F, Donnelly JC, Bennett K, Damkier P, Ní Áinle F, Cleary BJ Tags: J Thromb Haemost Source Type: research

Mechanisms of Vascular Permeability and Remodeling Associated with Hemarthrosis in Factor VIII-Deficient Mice.
CONCLUSIONS: Intact hemostasis at the time of hemarthrosis and during healing are both critical to prevent vascular remodeling, which appears worse with severe and prolonged FVIII deficiency. Unbiased RNA sequencing revealed potential targets for intervention and biomarker development to improve management of HA. This article is protected by copyright. All rights reserved. PMID: 31301687 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - July 13, 2019 Category: Hematology Authors: Cooke EJ, Wyseure T, Zhou JY, Gopal S, Nasamran CA, Fisch KM, Manon-Jensen T, Karsdal MA, Mosnier LO, von Drygalski A Tags: J Thromb Haemost Source Type: research

Definitions, adjudication, and reporting of pulmonary embolism-related death in clinical studies: a systematic review.
CONCLUSIONS: Only half of the included studies reported definitions for PE-related death, which were very heterogeneous. Case-fatality rate of VTE events varied widely across studies. Standardization of the definition and guidance on adjudication and reporting of PE-related death is needed. This article is protected by copyright. All rights reserved. PMID: 31301689 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - July 13, 2019 Category: Hematology Authors: Kraaijpoel N, Tritschler T, Guillo E, Girard P, Le Gal G Tags: J Thromb Haemost Source Type: research

Pass interference: Getting in the way of platelets.
PMID: 31301115 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - July 12, 2019 Category: Hematology Authors: Lee RH, Neal MD, Sen Gupta A Tags: J Thromb Haemost Source Type: research

Platelet-derived extracellular vesicles released after trauma promote hemostasis and contribute to DVT in mice.
CONCLUSIONS: These data demonstrate that trauma results in significant release of PEVs which are both pro-hemostatic and pro-thrombotic. The effects of PEVs can be mitigated by treatment with HCQ, suggesting the potential use as a form of DVT prophylaxis. This article is protected by copyright. All rights reserved. PMID: 31294514 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - July 11, 2019 Category: Hematology Authors: Dyer MR, Alexander W, Hassoune A, Chen Q, Alvikas J, Liu Y, Haldeman S, Plautz W, Loughran P, Li H, Boone B, Sadovsky Y, Sunnd P, Zuckerbraun BS, Neal MD Tags: J Thromb Haemost Source Type: research

Protease-Activated Receptors 1 and 3 are Differentially Expressed on Human Monocyte Subsets and are Upregulated by Lipopolysaccharide Ex Vivo and In Vivo.
This study investigated the expression pattern of PAR1 and PAR3 on human monocyte subsets. Furthermore, a possible regulation of the expression of PAR1 and PAR3 in these cells by inflammatory activation were studied. CD16+ monocytes showed significantly higher levels of PAR1 and PAR3 as compared with CD16- monocytes. Ex vivo treatment of whole blood with lipopolysaccharide (LPS) increased PAR1 and PAR3 messenger ribonucleic acid (mRNA) in human monocytes. In addition, increase of PAR1 was seen in all three subsets upon LPS treatment, whereas PAR3 increased significantly only in CD16- monocytes and nonclassical CD16+ monocy...
Source: Thrombosis and Haemostasis - July 10, 2019 Category: Hematology Authors: Thaler B, Hohensinner PJ, Baumgartner J, Haider P, Krychtiuk KA, Schörgenhofer C, Jilma B, Hell L, Fischer MB, Huber K, Hengstenberg C, Speidl WS, Wojta J Tags: Thromb Haemost Source Type: research

Elevated thrombin generation in patients with congenital disorder of glycosylation and combined coagulation factor deficiencies.
CONCLUSION: A thrombin generation assay revealed a hypercoagulant in vitro phenotype under baseline condition; this was accentuated by impaired involvement of the protein C system. This procoagulant phenotype may thus reflect the risk of severe vascular complications. Further research will have to determine whether the thrombin generation assay is predictive of vascular events. This article is protected by copyright. All rights reserved. PMID: 31271700 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - July 4, 2019 Category: Hematology Authors: Pascreau T, de la Morena-Barrio ME, Lasne D, Serrano M, Bianchini E, Kossorotoff M, Boddaert N, Bruneel A, Seta N, Vicente V, de Lonlay P, Corral J, Borgel D Tags: J Thromb Haemost Source Type: research

A Genome Wide Association Study on plasma FV levels identified PLXDC2 as a new modifier of the coagulation process.
CONCLUSION: Our study identified PLXDC2 as a new molecular player of the coagulation process. This article is protected by copyright. All rights reserved. PMID: 31271701 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - July 4, 2019 Category: Hematology Authors: Thibord F, Hardy L, Ibrahim-Kosta M, Saut N, Pulcrano-Nicolas AS, Goumidi L, Civelek M, Eriksson P, Deleuze JF, Le Goff W, Trégouët DA, Morange PE Tags: J Thromb Haemost Source Type: research

Extended treatment with edoxaban in cancer patients with venous thromboembolism: a post-hoc analysis of the Hokusai-VTE Cancer study.
CONCLUSIONS: The rates of recurrent VTE or major bleeding are relatively low among patients with active cancer receiving extended anticoagulant therapy beyond 6 months. Extended treatment with oral edoxaban appears as effective and safe as subcutaneous dalteparin. This article is protected by copyright. All rights reserved. PMID: 31271705 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - July 4, 2019 Category: Hematology Authors: Di Nisio M, van Es N, Carrier M, Wang TF, Garcia D, Segers A, Weitz J, Buller H, Raskob G Tags: J Thromb Haemost Source Type: research

Clinical and laboratory practice for lupus anticoagulant testing: an International Society of Thrombosis and Haemostasis Scientific Standardization Committee survey.
CONCLUSIONS: Although some of the variability in practice in LA testing reflects the lack of substantive data to underpin evidence-based recommendations, a more uniform approach, based on further guidance, should reduce the inter-centre variability of LA testing. This article is protected by copyright. All rights reserved. PMID: 31271706 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - July 4, 2019 Category: Hematology Authors: Cohen H, Mackie IJ, Devreese KMJ, International Society for Thrombosis and Haemostasis Scientific Standardization Committee for Lupus Anticoagulant/Antiphospholipid Antibodies Tags: J Thromb Haemost Source Type: research

Variability of von Willebrand factor-related parameters in endothelial colony forming cells.
CONCLUSIONS: We observed variations in morphology, maximum cell density, VWF production and angiogenic potential between healthy control ECFCs. These variations seem to be attributable to differences in aging and endoMT. Since variations correlate with cell density, we believe that ECFCs maintain a powerful tool to study vascular diseases. It is however important to compare cell lines with the same characteristics and perform experiments at maximum cell density. This article is protected by copyright. All rights reserved. PMID: 31265169 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - July 2, 2019 Category: Hematology Authors: de Jong A, Weijers E, Dirven R, de Boer S, Streur J, Eikenboom J Tags: J Thromb Haemost Source Type: research

Does the Villalta scale capture the essence of post-thrombotic syndrome? A qualitative study of patient experience and expert opinion.
CONCLUSION: Our findings indicate that the Villalta scale does not capture typical PTS complaints or their importance to the patients. A revision of the diagnosis and grading should be considered. This article is protected by copyright. All rights reserved. PMID: 31265193 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - July 2, 2019 Category: Hematology Authors: Engeseth M, Enden T, Andersen MH, Sandset PM, Wik HS Tags: J Thromb Haemost Source Type: research

miR-34b-3p May Promote Antiplatelet Efficiency of Aspirin by Inhibiting Thromboxane Synthase Expression.
Abstract Aspirin has been widely used for the prevention of cardiovascular diseases, but its antiplatelet efficiency varies between individuals. The present study aimed to evaluate response to aspirin based on gene profiles as well as potential regulating pathways using human blood samples and cell lines. Platelet function in patients 50 years or older with coronary artery disease on 100 mg/day aspirin was measured by light transmission aggregometry (LTA) of arachidonic acid (AA)-induced platelet aggregation. The expression of eight candidate genes-PTGS1/COX1, PLA2G4A, PLA2G6, PLA2G7, TBXAS1, TBXA2R, PTGIR, and IT...
Source: Thrombosis and Haemostasis - July 2, 2019 Category: Hematology Authors: Liu WW, Wang H, Chen XH, Fu SW, Liu ML Tags: Thromb Haemost Source Type: research

Apixaban Suppresses the Release of TF-Positive Microvesicles and Restrains Cancer Cell Proliferation through Directly Inhibiting TF-fVIIa Activity.
This study examined the ability of direct oral anticoagulants (DOACs), apixaban and rivaroxaban, to inhibit the release of TF+MV from two cell lines (MDA-MB-231 and AsPC-1) as well as cell proliferation.Activation of the cells with fXa (10 nM) enhanced the release of TF+MV but was suppressed in the presence of either DOAC. These MVs were found to contain fVIIa, but not fXa. Incubation of cell lines with apixaban (1.8 µM) but not rivaroxaban (1.8 µM), in the absence of fXa decreased the release of TF+MV below that of resting cells, in a PAR2-dependent manner. Furthermore, incubation with apixaban reduced the pro...
Source: Thrombosis and Haemostasis - July 2, 2019 Category: Hematology Authors: Featherby S, Madkhali Y, Maraveyas A, Ettelaie C Tags: Thromb Haemost Source Type: research

Linking Complement Activation, Coagulation, and Neutrophils in Transplant-Associated Thrombotic Microangiopathy.
Abstract Transplant-associated thrombotic microangiopathy (TA-TMA) is a severe and life-threatening complication of hematopoietic cell transplantation (HCT) that often coincides with graft-versus-host-disease (GVHD). Although endothelial damage seems to be the common denominator for both disorders, the role of complement system, neutrophils, and coagulation has not been clarified. In an effort to distinguish the pathogenesis of TA-TMA from GVHD, we evaluated markers of complement activation, neutrophil extracellular trap (NET) release, endothelial damage, and activation of coagulation cascade in the circulation of...
Source: Thrombosis and Haemostasis - July 2, 2019 Category: Hematology Authors: Gavriilaki E, Chrysanthopoulou A, Sakellari I, Batsis I, Mallouri D, Touloumenidou T, Papalexandri A, Mitsios A, Arampatzioglou A, Ritis K, Brodsky RA, Mitroulis I, Anagnostopoulos A Tags: Thromb Haemost Source Type: research

Lysophosphatidylcholine in Platelet Microvesicles: The Grease for Cardiovascular Disease.
PMID: 31266081 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - July 2, 2019 Category: Hematology Authors: Koenen RR Tags: Thromb Haemost Source Type: research

Improved Population-Based Clinical Outcomes of Patients with Atrial Fibrillation by Compliance with the Simple ABC (Atrial Fibrillation Better Care) Pathway for Integrated Care Management: A Nationwide Cohort Study.
This study evaluated whether compliance with the Atrial fibrillation Better Care (ABC) pathway for integrated care management ("A" Avoid stroke; "B" Better symptom management; "C" Cardiovascular risk and Comorbidity optimization) would improve population-based clinical outcomes in a nationwide AF cohort. METHODS AND RESULTS:  From the Korea National Health Insurance Service database, a total of 204,842 nonvalvular AF patients were enrolled between January 1, 2005 and December 31, 2015. Patients that fulfilled all criteria of the ABC pathway were defined as the "ABC" group, ...
Source: Thrombosis and Haemostasis - July 2, 2019 Category: Hematology Authors: Yoon M, Yang PS, Jang E, Yu HT, Kim TH, Uhm JS, Kim JY, Sung JH, Pak HN, Lee MH, Joung B, Lip GYH Tags: Thromb Haemost Source Type: research

Glycans and Glycan-Binding Proteins in Atherosclerosis.
Abstract Complex glycans are readily accessible on the endothelium and on cell and plasma components. They interact with glycan-binding proteins which translate their structure into function. Advanced analytical tools are available to investigate their structure and functional interactions. Modifications to glycan structures which alter their capacity to bind proteins are particularly relevant in atherosclerosis. We summarize the regulatory role of glycans and their binding partners in the development of the disease. Given their complexity, accessibility, and important functional role, glycans and glycan-binding p...
Source: Thrombosis and Haemostasis - July 2, 2019 Category: Hematology Authors: Eckardt V, Weber C, von Hundelshausen P Tags: Thromb Haemost Source Type: research

Horizontal RNA transfer goes deep: platelet consumption and microRNA utilization by vascular smooth muscle cells.
PMID: 31257731 [PubMed - in process] (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - July 1, 2019 Category: Hematology Authors: Goldfinger LE, Edelstein LC Tags: J Thromb Haemost Source Type: research

Commentary on: Circulating plasmablasts contribute to antiphospholipid antibody production, associated with type  I interferon upregulation.
Commentary on: Circulating plasmablasts contribute to antiphospholipid antibody production, associated with type I interferon upregulation. J Thromb Haemost. 2019 Jul;17(7):1030-1032 Authors: Yin D, de Laat B PMID: 31257732 [PubMed - in process] (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - July 1, 2019 Category: Hematology Authors: Yin D, de Laat B Tags: J Thromb Haemost Source Type: research

The American College of Chest Physicians score to assess the risk of bleeding during anticoagulation in patients with venous thromboembolism-Response.
PMID: 31257733 [PubMed - in process] (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - July 1, 2019 Category: Hematology Authors: Tosetto A, Palareti G, manuscript authors Tags: J Thromb Haemost Source Type: research

Corrigendum.
Authors: PMID: 31257734 [PubMed - in process] (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - July 1, 2019 Category: Hematology Tags: J Thromb Haemost Source Type: research

What the Neighbors Say.
Authors: PMID: 31257735 [PubMed - in process] (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - July 1, 2019 Category: Hematology Tags: J Thromb Haemost Source Type: research

Minimizing the "Aggravation" of Platelet Aggregation: The Need for Improved Assessments of Platelet Function.
Minimizing the "Aggravation" of Platelet Aggregation: The Need for Improved Assessments of Platelet Function. Thromb Haemost. 2019 Jul;119(7):1031-1032 Authors: Varon D PMID: 31234216 [PubMed - in process] (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - June 25, 2019 Category: Hematology Authors: Varon D Tags: Thromb Haemost Source Type: research

Microbubble Enhanced Ultrasound-Assisted Catheter-Directed Thrombolysis for VTE-A Sound Idea?
PMID: 31234217 [PubMed - in process] (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - June 25, 2019 Category: Hematology Authors: Sharp ASP Tags: Thromb Haemost Source Type: research

Predictors for Residual Pulmonary Vascular Obstruction after Unprovoked Pulmonary Embolism: Implications for Clinical Practice-The PADIS-PE Trial.
CONCLUSION:  Six months after a first unprovoked PE, age > 65 years, PVOI ≥ 25% at PE diagnosis, elevated factor VIII, or chronic respiratory disease were found to be independent predictors for residual pulmonary vascular obstruction. CLINICAL TRIALS REGISTRATION:  URL: http://www.controlled-trials.com. Unique identifier: NCT00740883. PMID: 31230343 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - June 23, 2019 Category: Hematology Authors: Raj L, Robin P, Le Mao R, Presles E, Tromeur C, Sanchez O, Pernod G, Bertoletti L, Jego P, Leven F, Lemarié CA, Martin A, Planquette B, Le Roux PY, Salaun PY, Nonent M, Girard P, Lacut K, Melac S, Mismetti P, Laporte S, Meyer G, Leroyer C, Couturaud F, P Tags: Thromb Haemost Source Type: research

Risk Factors for Major Bleeding during Prolonged Anticoagulation Therapy in Patients with Venous Thromboembolism: From the COMMAND VTE Registry.
CONCLUSION:  Major bleeding events were not uncommon during prolonged anticoagulation therapy in real-world VTE patients. Active cancer, previous major bleeding, anemia, thrombocytopenia, and old age were the independent risk factors for major bleeding. PMID: 31230344 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - June 23, 2019 Category: Hematology Authors: Kim K, Yamashita Y, Morimoto T, Kitai T, Yamane T, Ehara N, Kinoshita M, Kaji S, Amano H, Takase T, Hiramori S, Oi M, Akao M, Kobayashi Y, Toyofuku M, Izumi T, Tada T, Chen PM, Murata K, Tsuyuki Y, Saga S, Sasa T, Sakamoto J, Kinoshita M, Togi K, Mabuchi Tags: Thromb Haemost Source Type: research

Gender and Outcomes following Guided De-Escalation of Antiplatelet Treatment in Acute Coronary Syndrome Patients: The TROPICAL-ACS Gender Substudy.
CONCLUSION:  Guided de-escalation of DAPT appears to be equally safe and effective in women and men. Especially in patients with increased bleeding risk and independent from gender, a guided DAPT de-escalation strategy may be used as an alternative treatment strategy. CLINICAL TRIAL REGISTRATION:  URL: https//www.clinicaltrials.gov. Unique Identifier: NCT: 01959451. PMID: 31226717 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - June 21, 2019 Category: Hematology Authors: Gross L, Kupka D, Trenk D, Geisler T, Hadamitzky M, Löw A, Orban M, Huber K, Kiss RG, Merkely B, Huczek Z, Beuthner BE, Hein-Rothweiler R, Baylacher M, Rizas K, Massberg S, Aradi D, Sibbing D, Jacobshagen C Tags: Thromb Haemost Source Type: research

Sex Differences in the Association between Inflammation and Ischemic Heart Disease.
CONCLUSION:  A strong link between bone marrow metabolism and impaired myocardial function and perfusion was observed in women, but not in men. Our data suggest that novel biomarkers of inflammation might help to identify women at risk for ischemic cardiomyopathy and to tailor disease management to the female cardiovascular phenotype. PMID: 31226718 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - June 21, 2019 Category: Hematology Authors: Fiechter M, Haider A, Bengs S, Marȩdziak M, Burger IA, Roggo A, Portmann A, Warnock GI, Schade K, Treyer V, Becker AS, Messerli M, Felten EV, Benz DC, Fuchs TA, Gräni C, Pazhenkottil AP, Buechel RR, Kaufmann PA, Gebhard C Tags: Thromb Haemost Source Type: research

Impaired Glycoprotein VI-Mediated Signaling and Platelet Functional Responses in CD45 Knockout Mice.
CONCLUSION:  We conclude that the truncated CD45 isoform regulates GPVI-mediated signaling and platelet functional responses by regulating SFK activation. PMID: 31226719 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - June 21, 2019 Category: Hematology Authors: Inamdar VV, Kostyak JC, Badolia R, Dangelmaier CA, Manne BK, Patel A, Kim S, Kunapuli SP Tags: Thromb Haemost Source Type: research

Antiphospholipid Syndrome in Chronic Thromboembolic Pulmonary Hypertension: A Well-Defined Subgroup of Patients.
Abstract Antiphospholipid syndrome (APS) is an acquired thrombophilia with an uncertain role in the development of chronic thromboembolic pulmonary hypertension (CTEPH). We aimed to assess the association of APS with the clinical phenotype of CTEPH. We retrospectively reviewed data of CTEPH patients referred to our center. Clinical, angiographic, and hemodynamic data were available for all patients. APS was diagnosed in the presence of one or more positive antiphospholipid (aPL) tests confirmed more than 12 weeks apart. Data were compared between APS-positive and APS-negative patients. From May 2013 to December 20...
Source: Thrombosis and Haemostasis - June 21, 2019 Category: Hematology Authors: Jiang X, Du Y, Cheng CY, Denas G, Zhou YP, Wu T, Zhang YX, Han ZY, Pengo V, Jing ZC Tags: Thromb Haemost Source Type: research

Revacept, a Novel Inhibitor of Platelet Adhesion, in Patients Undergoing Elective PCI-Design and Rationale of the Randomized ISAR-PLASTER Trial.
ors Abstract Despite dual antiplatelet therapy patients undergoing percutaneous coronary intervention (PCI) continue to experience periprocedural ischemic events. In addition, all currently used antithrombotic drugs increase the bleeding risk. Thus, there is an unmet clinical need for antithrombotic strategies with improved efficacy and no increase in bleeding. Revacept is a novel, lesion-directed antithrombotic drug that does not interfere with the function of circulating platelets. This dimeric fusion protein of the extracellular domain of glycoprotein VI (the major platelet collagen receptor) and the human Fc-f...
Source: Thrombosis and Haemostasis - June 21, 2019 Category: Hematology Authors: Schüpke S, Hein-Rothweiler R, Mayer K, Janisch M, Sibbing D, Ndrepepa G, Hilz R, Laugwitz KL, Bernlochner I, Gschwendtner S, Kupka D, Gori T, Zeiher AM, Schunkert H, Massberg S, Kastrati A, ISAR-PLASTER-Trial Investigators Tags: Thromb Haemost Source Type: research

Plasma Levels of Mannose-Binding Lectin and Future Risk of Venous Thromboembolism.
en JB Abstract BACKGROUND: Animal and observational studies have suggested a pathophysiological role for complement in venous thromboembolism (VTE), but the initiating mechanisms are unknown. Mannose-binding lectin (MBL) bound to altered host cells leads to activation of the lectin complement pathway, and both high and low MBL levels have been implicated in the pathophysiology of cardiovascular disease. OBJECTIVES: To investigate the association between plasma MBL levels and future risk of incident VTE. METHODS: We conducted a nested case-control study in 417 VTE patients and 849 age- and sex-matched con...
Source: Thrombosis and Haemostasis - June 20, 2019 Category: Hematology Authors: Liang RA, Høiland II, Ueland T, Aukrust P, Snir O, Hindberg K, Braekkan SK, Garred P, Mollnes TE, Hansen JB Tags: J Thromb Haemost Source Type: research

Predicting the risk of recurrent venous thrombosis: what the future might bring.
This article is protected by copyright. All rights reserved. PMID: 31220398 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - June 20, 2019 Category: Hematology Authors: Lijfering WM, Timp JF, Cannegieter SC Tags: J Thromb Haemost Source Type: research

Sex matters: Practice 5P's when treating young women with venous thromboembolism.
This article is protected by copyright. All rights reserved. PMID: 31220399 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - June 20, 2019 Category: Hematology Authors: Bistervels IM, Scheres LJJ, Hamulyák EN, Middeldorp S Tags: J Thromb Haemost Source Type: research

New insights into cytoskeletal remodeling during platelet production.
This article is protected by copyright. All rights reserved. PMID: 31220402 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - June 20, 2019 Category: Hematology Authors: Ghalloussi D, Dhenge A, Bergmeier W Tags: J Thromb Haemost Source Type: research

Anticoagulation therapy patterns for acute treatment of venous thromboembolism in GARFIELD-VTE patients.
CONCLUSION: AC treatment patterns vary by patient population, geographic region and site of VTE. Guidelines for AC therapy are not always adhered to. This article is protected by copyright. All rights reserved. PMID: 31220403 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - June 20, 2019 Category: Hematology Authors: Haas S, Ageno W, Weitz JI, Goldhaber SZ, Turpie AGG, Goto S, Angchaisuksiri P, Dalsgaard Nielsen J, Kayani G, Zaghdoun A, Farjat AE, Schellong S, Bounameaux H, Mantovani LG, Prandoni P, Kakkar AK Tags: J Thromb Haemost Source Type: research

Antiphosphatidylserine/prothrombin complex antibodies as a determinant of prothrombotic plasma fibrin clot properties in patients with antiphospholipid syndrome.
CONCLUSIONS: We identified aPS/PT antibodies as a determinant of denser and poorly lysable plasma fibrin clots formation in APS patients. The association of elevated aPS/PT antibodies with thromboembolism in APS could be at least in part mediated by prothrombotic clot properties. This article is protected by copyright. All rights reserved. PMID: 31220407 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - June 20, 2019 Category: Hematology Authors: Zabczyk M, Celińska-Löwenhoff M, Plens K, Iwaniec T, Musiał J, Undas A Tags: J Thromb Haemost Source Type: research

Trauma-targeted Delivery of Tranexamic Acid Improves Hemostasis and Survival in Rat Liver Hemorrhage Model.
CONCLUSION: Overall, the studies establish the potential of targeted TXA delivery for safe injury site-selective enhancement and stabilization of hemostatic clots to improve survival in trauma. This article is protected by copyright. All rights reserved. PMID: 31220416 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - June 20, 2019 Category: Hematology Authors: Girish A, Hickman DA, Banerjee A, Luc N, Ma Y, Miyazawa K, Sekhon UDS, Sun M, Huang S, Sen Gupta A Tags: J Thromb Haemost Source Type: research

Rivaroxaban pharmacodynamics in healthy volunteers evaluated with thrombin generation and the active protein C system: modeling and assessing inter-individual variability.
CONCLUSIONS: This low-to-moderate rivaroxaban PD variability in healthy volunteers contrasts with the substantial PK variability, and deserves to be studied in different patient settings. This article is protected by copyright. All rights reserved. PMID: 31215111 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - June 19, 2019 Category: Hematology Authors: Siguret V, Abdoul J, Delavenne X, Curis E, Carlo A, Blanchard A, Salem JE, Gaussem P, Funck-Brentano C, Azizi M, Mismetti P, Loriot MA, Lecompte T, Gouin-Thibault I Tags: J Thromb Haemost Source Type: research

The Role of a specialist bridging service. A New Zealand prospective study of 600 patients.
This article is protected by copyright. All rights reserved. PMID: 31215756 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - June 19, 2019 Category: Hematology Authors: Ruell J, Smith A, Perera T, Carter J Tags: J Thromb Haemost Source Type: research

Toll-like receptor 2 and 7 mediate coagulation activation and coagulopathy in murine sepsis.
CONCLUSIONS: Murine sepsis leads to increased procoagulant response, thrombocytopenia, and global coagulopathy. TLR2 and TLR7 plays an important role in procoagulant production and in SIC. This article is protected by copyright. All rights reserved. PMID: 31211901 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - June 18, 2019 Category: Hematology Authors: Williams B, Neder J, Cui P, Suen A, Tanaka K, Zou L, Chao W Tags: J Thromb Haemost Source Type: research

Cell surface expression of HLA I molecules as a marker of young platelets.
CONCLUSION: Overall, our results highlight the relevance of MHC I/HLA I expression as a valuable parameter to identify young platelets. This article is protected by copyright. All rights reserved. PMID: 31207003 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - June 17, 2019 Category: Hematology Authors: Angénieux C, Dupuis A, Gachet C, de la Salle H, Maître B Tags: J Thromb Haemost Source Type: research

Laboratory Monitoring in Emicizumab-Treated Persons with Hemophilia A.
nnagl M Abstract Hemophilia A (HA) is an X-linked hereditary bleeding disorder caused by deficiency of coagulation factor (F) VIII activity. One of the greatest complications in the treatment of HA is the development of neutralizing alloantibodies, known as FVIII inhibitors. HA patients who develop FVIII inhibitors have limited treatment options available to them and experience greater disease- and treatment-related burdens than HA patients without FVIII inhibitors. Emicizumab, a recently approved bispecific monoclonal antibody, mimics the function of FVIIIa by bridging FIXa and FX to restore effective hemostasis....
Source: Thrombosis and Haemostasis - June 16, 2019 Category: Hematology Authors: Müller J, Pekrul I, Pötzsch B, Berning B, Oldenburg J, Spannagl M Tags: Thromb Haemost Source Type: research

Myocardial Infarction as a Transient Risk Factor for Incident Venous Thromboembolism: Results from a Population-Based Case-Crossover Study.
In conclusion, our findings suggest that the increased VTE risk after MI may to a large extent be explained by concomitant conditions related to MI, particularly infections and immobilization. PMID: 31203579 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - June 16, 2019 Category: Hematology Authors: Sejrup JK, Børvik T, Grimnes G, Isaksen T, Hindberg K, Hansen JB, Morelli VM, Brækkan SK Tags: Thromb Haemost Source Type: research

Risk prediction of recurrent venous thrombosis; where are we now and what can we add?
CONCLUSIONS: The ability to distinguish patients' recurrence risks is lower than proposed in the original prediction model studies and dependent on the definition that is used for an unprovoked first event. Furthermore, our results suggest that a more refined risk estimation is possible, also in patients with a provoked first event, who are currently all classified as low risk. This article is protected by copyright. All rights reserved. PMID: 31188515 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - June 12, 2019 Category: Hematology Authors: Timp JF, Lijfering WM, Rosendaal FR, le Cessie S, Cannegieter SC Tags: J Thromb Haemost Source Type: research