European Journal of Pharmaceutics and Biopharmaceutics This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Formulation study of PLGA in situ films for topical delivery of salicylates
In this study, a non-commercial poly(lactic-co-glycolic acid) (PLGA) was chosen to formulate an FFS containing salicylic acid (SA) and methyl salicylate (MS). This unique combination is advantageous from a therapeutic point of view, as it enabled modified salicylate release. It is beneficial from a technological perspective too, because it improved thermal, rheological, and adhesive properties of the in situ film. DSC revealed complete dissolution of SA and good miscibility of MS with the polymer. MS also ensures optimal viscoelastic and adhesive properties of the film, leading to prolonged and sustained drug release. The ...
Source: European Journal of Pharmaceutics and Biopharmaceutics - April 13, 2024 Category: Drugs & Pharmacology Authors: Eva Snejdrova Jan Loskot Andrea Veris Petr Kastner Rudolf Andrys Source Type: research

Layer-by-layer self-assembly embedding of nattokinase in chitosan/ γ-polyglutamic acid: Preparation, fibrinolytic activity, stability, and in vitro digestion study
This study aims to increase NK's oral and storage stability by embedding NK in microcapsules prepared with chitosan (CS) and γ-polyglutamic acid (γ-PGA). The paper prepared a double-layer NK oral delivery system by layer self-assembly and characterized its stability and in vitro simulated digestion. According to the research results, the bilayer putamen structure has a protective effect on NK, which not only maintains high activity in various environments (such as acid-base, high temperature) and long-term storage (60 days), but also effectively protects the loaded NK from being destroyed in gastric fluid and achieves it...
Source: European Journal of Pharmaceutics and Biopharmaceutics - April 10, 2024 Category: Drugs & Pharmacology Authors: Zhihan Liu Yan He Hua Zhang Xia Ma Source Type: research

Engineering resveratrol-loaded chitosan nanoparticles for potential use against Helicobacter pylori infection
Eur J Pharm Biopharm. 2024 Apr 6:114280. doi: 10.1016/j.ejpb.2024.114280. Online ahead of print.ABSTRACTHelicobacter pylori (H. pylori) is a microorganism directly linked to severe clinical conditions affecting the stomach. The virulence factors and its ability to form biofilms increase resistance to conventional antibiotics, growing the need for new substances and strategies for the treatment of H. pylori infection. The trans-resveratrol (RESV), a bioactive polyphenol from natural sources, has a potential activity against this gastric pathogen. Here, Chitosan nanoparticles (NP) containing RESV (RESV-NP) were developed for...
Source: European Journal of Pharmaceutics and Biopharmaceutics - April 8, 2024 Category: Drugs & Pharmacology Authors: Larissa Sp ósito Diana Fonseca Suzana Gon çalves Carvalho Rafael Miguel S ábio Gabriel Marena Ta ís Maria Bauab Andr éia Bagliotti Meneguin Paula Parreira M Cristina L Martins Marlus Chorilli Source Type: research

Throat spray formulated with virucidal Pharmaceutical excipients as an effective early prophylactic or treatment strategy against pharyngitis post-exposure to SARS CoV-2
In conclusion, our CUR-loaded SNESNS formula, at 5 µg/mL concentration, shows promising effect as a prophylactic throat spray against SARS-CoV-2 and as a treatment for pharyngitis.PMID:38588829 | DOI:10.1016/j.ejpb.2024.114279 (Source: European Journal of Pharmaceutics and Biopharmaceutics)
Source: European Journal of Pharmaceutics and Biopharmaceutics - April 8, 2024 Category: Drugs & Pharmacology Authors: Amira A Boseila Ahmed Z Ghareeb Miral G AbdElwahab Mohamed G Seadawy Ahmed A Al-Karmalawy Nashwa W Yassa Doaa A Ghareeb Source Type: research

Continuous direct compression of a commercially batch-manufactured tablet formulation with two different processing lines
In this study, processing of a commercially batch-manufactured tablet product was tested with two continuous direct compression lines while keeping the original formulation composition and tablet quality requirements. Tableting runs were conducted with different values of process parameters. Changes in parameter settings were found to cause differences in tablet properties. Most of these quality properties could be controlled and maintained within the set limits effortlessly already at this stage of studies. However, the API content and content uniformity seemed to require more investigation. The observed content uniformit...
Source: European Journal of Pharmaceutics and Biopharmaceutics - April 7, 2024 Category: Drugs & Pharmacology Authors: Jenna Lyytik äinen Pawel Stasiak Tom áš Kubelka Ivan Bogaerts Adam Wanek Bart Stynen James Holman Jarkko Ketolainen Tuomas Ervasti Ossi Korhonen Source Type: research

Exploring the potential of black cumin derived nanovesicles for miRNA drug delivery
Eur J Pharm Biopharm. 2024 Apr 4:114275. doi: 10.1016/j.ejpb.2024.114275. Online ahead of print.ABSTRACTLiposomes is a non-viral vector drug delivery system. Nevertheless, the existing commercial liposomes are quite expensive and not always affordable, particularly in developing countries. To address this challenge, plant-derived nanoparticles offer a cost-effective alternative while maintaining similar drug delivery capabilities. Hence, this study aimed to explore the potential of nanovesicles derived from black cumin (Nigella sativa) as a miRNA delivery system. Gradient sucrose-centrifugation was utilized to separate the...
Source: European Journal of Pharmaceutics and Biopharmaceutics - April 6, 2024 Category: Drugs & Pharmacology Authors: Adelina Khristiani Rahayu Azzania Fibriani Marselina Irasonia Tan Source Type: research

Can (Natural) deep eutectic systems increase the efficacy of ocular therapeutics?
Eur J Pharm Biopharm. 2024 Apr 4:114276. doi: 10.1016/j.ejpb.2024.114276. Online ahead of print.ABSTRACTThe eye is one of the most complex organs in the human body, with a unique anatomy and physiology, being divided into anterior and posterior segments. Ocular diseases can occur in both segments, but different diseases affect different segments. Glaucoma and cataracts affect the anterior segment, while macular degeneration and diabetic retinopathy occur in the posterior segment. The easiest approach to treat ocular diseases, especially in the anterior segment, is through the administration of topical eye drops, but this r...
Source: European Journal of Pharmaceutics and Biopharmaceutics - April 6, 2024 Category: Drugs & Pharmacology Authors: C élia Sarmento Ana Rita C Duarte Ana Rita Jesus Source Type: research

Is there a fast track ("Darmstrasse") for fluids in the small intestine? evidence from magnetic resonance imaging
Eur J Pharm Biopharm. 2024 Apr 4:114277. doi: 10.1016/j.ejpb.2024.114277. Online ahead of print.ABSTRACTThe transit and distribution pattern of fluids in the small intestine is a key parameter for the dissolution and absorption of drugs. Although some information is known about the small intestinal water content after administration of fluid volumes and meals, the intestinal transit of orally ingested fluids and solutions has been barely investigated. The aim of this three-arm, cross-over, 9-subject human study was to investigate the transit of orally ingested water in the small intestine under fasting and postprandial con...
Source: European Journal of Pharmaceutics and Biopharmaceutics - April 6, 2024 Category: Drugs & Pharmacology Authors: Linus Gro ßmann Katharina Springub Linda Kr üger Fabian Winter Adrian Rump Marie-Luise Kromrey Robin B ülow Norbert Hosten Jennifer Dressman Werner Weitschies Michael Grimm Source Type: research

Corrigendum to 'Co-assembly of doxorubicin and curcumin targeted micelles for synergistic delivery and improving anti-tumor efficacy' [Eur. J. Pharma. Biopharm. 112 (2017) 209-223]
Eur J Pharm Biopharm. 2024 Apr 4:114273. doi: 10.1016/j.ejpb.2024.114273. Online ahead of print.NO ABSTRACTPMID:38580552 | DOI:10.1016/j.ejpb.2024.114273 (Source: European Journal of Pharmaceutics and Biopharmaceutics)
Source: European Journal of Pharmaceutics and Biopharmaceutics - April 5, 2024 Category: Drugs & Pharmacology Authors: Wenzhuan Ma Qiang Guo Ying Li Xiaohui Wang Jinling Wang Pengfei Tu Source Type: research