PARP inhibitors as maintenance therapy in newly diagnosed advanced ovarian cancer: A meta-analysis.
Abstract BACKGROUND: Up to 70% of the patients with advanced ovarian cancer have a relapse after primary therapy. New agents and approaches are urgently needed to avoid or slow down the reccurence. OBJECTIVES: To investigate the efficacy of PARP inhibitors (PARPis) as maintenance treatment in patients with newly diagnosed advanced ovarian cancer. SEARCH STRATEGY: PubMed, Medline, Embase, Cochrane Library and Web of Science databases. SELECTION CRITERIA: All randomized clinical trials (RCTs) that compared PARPis and placebo as first-line maintenance therapy in ovarian cancer. DATA COLLECTION AND...
Source: BJOG : An International Journal of Obstetrics and Gynaecology - July 12, 2020 Category: OBGYN Authors: Lin Q, Liu W, Xu S, Shang H, Li J, Guo Y, Tong J Tags: BJOG Source Type: research

A systematic review on reported outcomes and outcome measures in female idiopathic chronic pelvic pain for the development of a core outcome set.
CONCLUSION: There is wide variation in reported outcomes and applied outcome measures in CPP trials. While a COS is developed and implemented, we propose an interim use of three commonly reported outcomes in each domain. These include: pain (pelvic pain, dyspareunia, dysmenorrhoea), life impact (quality of life, emotional functioning, physical functioning), clinical effectiveness (efficacy, satisfaction, cost effectiveness, return to daily activities) and adverse events (surgical, perioperative observations, non-surgical). PMID: 32654406 [PubMed - as supplied by publisher] (Source: BJOG : An International Journal of O...
Source: BJOG : An International Journal of Obstetrics and Gynaecology - July 12, 2020 Category: OBGYN Authors: Ghai V, Subramanian V, Jan H, Pergialiotis V, Thakar R, Doumouchtsis SK Tags: BJOG Source Type: research

Sacrocolpopexy tends to be superior to transvaginal mesh surgery.
Abstract The use of synthetic mesh prostheses to treat pelvic organ prolapse (POP) remains highly controversial. Despite complete restriction on vaginally placed mesh in Australia and New Zealand (2017), the UK (2018), and the USA (2019), transvaginal mesh (TVM) prolapse repair remain widely in many countries, including China and most of East Asia. Sacrocolpopexy (SC) is widely considered as the gold-standard for surgical correction of vaginal vault prolapse. (Maher C et al,. Cochrane Database of Systematic Reviews 2016, Issue 11. Art,) while hysteropexy is an increasingly popular option for uterine prolapse (Meri...
Source: BJOG : An International Journal of Obstetrics and Gynaecology - July 10, 2020 Category: OBGYN Authors: Veit-Rubin N, Cartwright R Tags: BJOG Source Type: research

New pathways to diagnose preeclampsia.
Abstract Correct clinical decision making that avoids unnecessary complications for the mother and the child, rests in differentiating when pre-eclampsia is present and when it is not. The first step is to always keep this condition in mind. There is no point in having the most up-to-date guidance if we do not recognize the palpebral edema of a pregnant woman that enters through our office door while looking at the computer screen. The second step is to achieve a diagnostic confirmation as soon as possible. The inaccuracy of the diagnostic criteria used - that are not based on the etiopathogenic knowledge - has be...
Source: BJOG : An International Journal of Obstetrics and Gynaecology - July 8, 2020 Category: OBGYN Authors: Herraiz I Tags: BJOG Source Type: research

Pregnancy and postpartum outcomes in a universally tested population for SARS-CoV-2 in New York City: A prospective cohort study.
Abstract OBJECTIVE: To describe differences in outcomes between pregnant women with and without COVID-19 DESIGN: Prospective cohort study of pregnant women consecutively admitted for delivery, and universally tested via nasopharyngeal (NP) swab for SARS-CoV-2 using reverse transcriptase polymerase chain reaction (RT-PCR). All infants of mothers with COVID-19 underwent SARS-CoV-2 testing. SETTING: Three New York City hospitals POPULATION: Pregnant women> 20 weeks' gestation admitted for delivery METHODS: Data were stratified by SARS-CoV-2 result and symptomatic status, and summarized using parametric and no...
Source: BJOG : An International Journal of Obstetrics and Gynaecology - July 7, 2020 Category: OBGYN Authors: Prabhu M, Cagino K, Matthews KC, Friedlander RL, Glynn SM, Kubiak JM, Yang YJ, Zhao Z, Baergen RN, DiPace JI, Razavi AS, Skupski DW, Snyder JR, Singh HK, Kalish RB, Oxford CM, Riley LE Tags: BJOG Source Type: research

Cost-effectiveness of HPV-based cervical screening based on first year results in the Netherlands : A modelling study.
CONCLUSIONS: The hrHPV-based screening programme is found to be more effective and cost effective than the cytology programme. Alternatives for the current triage strategy should be considered to lower the number of unnecessary referrals. PMID: 32638462 [PubMed - as supplied by publisher] (Source: BJOG : An International Journal of Obstetrics and Gynaecology)
Source: BJOG : An International Journal of Obstetrics and Gynaecology - July 7, 2020 Category: OBGYN Authors: Jansen EEL, Naber SK, Aitken CA, de Koning HJ, van Ballegooijen M, de Kok IMCM Tags: BJOG Source Type: research

The influence of learning curve of robot-assisted laparoscopy on oncological outcomes in early stage cervical cancer: an observational cohort study.
CONCLUSION: The learning phase of robot-assisted laparoscopy in early stage cervical cancer in this institutional cohort is at least 61 procedures, with higher survival rates in the patients treated thereafter. The learning curve of robot-assisted laparoscopy affects oncological outcomes and warrants more attention in the design of future studies. PMID: 32627934 [PubMed - as supplied by publisher] (Source: BJOG : An International Journal of Obstetrics and Gynaecology)
Source: BJOG : An International Journal of Obstetrics and Gynaecology - July 6, 2020 Category: OBGYN Authors: Baeten IGT, Hoogendam JP, Schreuder HWR, Jürgenliemk-Schulz IM, Verheijen RHM, Zweemer RP, Gerestein CG Tags: BJOG Source Type: research

Vitamin D: Another puzzle piece in pelvic floor protection.
This study determined that the group of women who experienced postpartum UI were not the same women who suffered from UI during pregnancy (Huebner, M. et al.; Int J Gynaecol Obstet 2010;110;249-51). PMID: 32621319 [PubMed - as supplied by publisher] (Source: BJOG : An International Journal of Obstetrics and Gynaecology)
Source: BJOG : An International Journal of Obstetrics and Gynaecology - July 4, 2020 Category: OBGYN Authors: Huebner M Tags: BJOG Source Type: research

Prevention of gestational diabetes: Where do we go from here?
Abstract Gestational diabetes mellitus (GDM) increases the risk for short-term adverse perinatal outcomes for mothers and their infants. In addition, women with GDM are at increased risk for type 2 diabetes, and their offspring also face long-term risk for diabetes and obesity. Women who develop GDM have a high rate of recurrence in subsequent pregnancies. However, prevention of GDM remains a significant challenge. Weight gain during pregnancy has not been consistently associated with development of GDM, and dietary and physical activity interventions have shown only modest benefit in reducing the risk for GDM. ...
Source: BJOG : An International Journal of Obstetrics and Gynaecology - July 4, 2020 Category: OBGYN Authors: Scifres C Tags: BJOG Source Type: research

Free-text patient experience data inform service development.
Abstract Understanding patients' experiences of treatment and care is essential to effective service development, and is therefore a common topic of investigation for clinicians and health services researchers. For service development, different kinds of investigation may be useful for a different purpose. Closed measures of patient satisfaction (e.g. rating scales) are useful in providing reproducible measures in specified domains; however, they are often limited both by the scope of predefined questions, and the level of detail they provide on processes affecting reported outcomes. Free-text data are therefore o...
Source: BJOG : An International Journal of Obstetrics and Gynaecology - July 4, 2020 Category: OBGYN Authors: Bracher M Tags: BJOG Source Type: research

Prenatal visualization of the torcular herophili by means of a Doppler technology highly sensitive for low velocity flow in the expert assessment of the posterior fossa: a prospective study.
CONCLUSIONS: The prenatal US visualization of the TH by means of newly developed Doppler technologies characterized by high sensitivity for low velocity flow is feasible and allows the indirect evaluation of the insertion cerebellar tentorium in the second trimester. PMID: 32619035 [PubMed - as supplied by publisher] (Source: BJOG : An International Journal of Obstetrics and Gynaecology)
Source: BJOG : An International Journal of Obstetrics and Gynaecology - July 3, 2020 Category: OBGYN Authors: Dall'Asta A, Grisolia G, Volpe N, Battista G, Schera L, Sorrentino F, Frusca T, Ghi T Tags: BJOG Source Type: research

The use of host cell DNA methylation analysis in the detection and management of women with advanced cervical intraepithelial neoplasia: a review.
Abstract This paper briefly reviews the role of hypermethylation of host cell genes in cervical carcinogenesis and discusses potential clinical applications of methylation analysis in the management of high-risk HPV (hrHPV) positive women. We argue that methylation assays can be used: 1. for primary triage of hrHPV positive women to detect cervical cancer and advanced CIN; 2. as secondary triage for women with minor cytological abnormalities to identify those with the highest risk of CIN3 or worse; 3. as exit test for women leaving the screening programme to identify cervical cancer and advanced CIN; and 4. to sup...
Source: BJOG : An International Journal of Obstetrics and Gynaecology - July 3, 2020 Category: OBGYN Authors: Kremer WW, Steenbergen RDM, Heideman DAM, Kenter GG, Meijer CJLM Tags: BJOG Source Type: research

Cervical self-sampling yields useful cytology.
Abstract Effective Cervical screening involves a complex sequence of interactions between women, clinical staff and systems. Even in well organised screening programmes, achieving high population coverage is challenging. The transition to using Human Papilloma Virus (HPV) testing as the primary screening modality, rather than cytology, has introduced the possibility of using a self-collected sample for the primary HPV test. This has been shown to be a reliable method of detecting CIN2+ (Polman et al, Lancet Oncology 2019;20(2):229-38). Regardless of the way the sample is collected, the low specificity of a positiv...
Source: BJOG : An International Journal of Obstetrics and Gynaecology - July 1, 2020 Category: OBGYN Authors: Denton KJ Tags: BJOG Source Type: research

Benefit of standardized risk assessment for postpartum hemorrhage.
Abstract Global estimates for 2017 indicated that there were 295,000 maternal deaths, 35 per cent lower than in 2000 with a decline in global maternal mortality ratio from 342 to 211 deaths per 100,000 live births (World Health Organization (WHO) 2019). Maternal hemorrhage is the leading direct cause of maternal death worldwide, representing 27% (20-36) of maternal deaths ( Say L, et al. Lancet 2014). Multiple large retrospective population cohorts have identified risk factors invariably associated with maternal hemorrhage including mode of delivery, prolonged labor, chorioamnionitis, and twins among others (Brile...
Source: BJOG : An International Journal of Obstetrics and Gynaecology - July 1, 2020 Category: OBGYN Authors: Contag S Tags: BJOG Source Type: research

Implementation of routine first trimester combined screening for pre-eclampsia: a clinical effectiveness study.
Abstract OBJECTIVE: Evaluate clinical effectiveness of the first trimester combined (FMF) pre-eclampsia screening programme when implemented in a public healthcare setting. DESIGN: Retrospective cohort study. SETTING: London tertiary hospital from January 2017 to March 2019. METHODS: 7720 women screened for pre-eclampsia according to National Institute for Health and Care Excellence (NICE) risk-based guidance and 4841 by the Fetal Medical Foundation (FMF) algorithm which combined maternal risk factors, blood pressure, PAPP-A and uterine artery Doppler indices in the first trimester. High risk was de...
Source: BJOG : An International Journal of Obstetrics and Gynaecology - July 1, 2020 Category: OBGYN Authors: Guy GP, Leslie K, Diaz Gomez D, Forenc K, Buck E, Khalil A, Thilaganathan B Tags: BJOG Source Type: research

Virtual pain relief for out-patient hysteroscopy.
Abstract We are all likely to need a blood test, a biopsy or wind up on the wrong end of an endoscope. We know that the experience is not going to be pleasant. Many of us will revert to techniques to divert attention away from painful stimuli, such as counting forwards or backwards in our heads, deep breathing, imagining tranquil places or listening to music. But the paper published in this issue of BJOG by (Neo D et al, BJOG 2020; xxxx) shows us how we can distract patients in a more sophisticated way, using virtual reality (VR) technology. The procedure the research groups chose to investigate was outpatient hys...
Source: BJOG : An International Journal of Obstetrics and Gynaecology - July 1, 2020 Category: OBGYN Authors: Clark TJ Tags: BJOG Source Type: research

Misoprostol for open myomectomy: a systematic review and meta-analysis of randomised control trials.
CONCLUSION: Moderate to high quality studies have established that misoprostol minimises blood loss and need for blood transfusion at open myomectomy. This low-cost and readily-available drug should be routinely administered prior to open myomectomy to improve clinical outcomes. PMID: 32613769 [PubMed - as supplied by publisher] (Source: BJOG : An International Journal of Obstetrics and Gynaecology)
Source: BJOG : An International Journal of Obstetrics and Gynaecology - July 1, 2020 Category: OBGYN Authors: Wali S, Balfoussia D, Touqmatchi D, Quinn S Tags: BJOG Source Type: research

Blair Bell Research Society: Annual Academic Meeting Abstracts.
Authors: PMID: 32529698 [PubMed] (Source: BJOG : An International Journal of Obstetrics and Gynaecology)
Source: BJOG : An International Journal of Obstetrics and Gynaecology - June 13, 2020 Category: OBGYN Tags: BJOG Source Type: research

The consequences of the COVID-19 pandemic.
PMID: 32529699 [PubMed - in process] (Source: BJOG : An International Journal of Obstetrics and Gynaecology)
Source: BJOG : An International Journal of Obstetrics and Gynaecology - June 13, 2020 Category: OBGYN Authors: Chien P Tags: BJOG Source Type: research

Re: Laparoscopic ablation or excision with helium thermal coagulator versus electrodiathermy for the treatment of mild-to-moderate endometriosis: randomised controlled trial.
PMID: 32529735 [PubMed - as supplied by publisher] (Source: BJOG : An International Journal of Obstetrics and Gynaecology)
Source: BJOG : An International Journal of Obstetrics and Gynaecology - June 12, 2020 Category: OBGYN Authors: Hirsch M, Duffy JMN, Farquhar CM, endo:outcomes an international collaboration harmonising outcomes, outcome measures for endometriosis research Tags: BJOG Source Type: research

Maternal transmission of SARS-COV-2 to the neonate, and possible routes for such transmission: A systematic review and critical analysis.
CONCLUSIONS: Neonatal COVID-19 infection is uncommon, uncommonly symptomatic, and the rate of infection is no greater when the baby is born vaginally, breastfed or allowed contact with the mother. PMID: 32531146 [PubMed - as supplied by publisher] (Source: BJOG : An International Journal of Obstetrics and Gynaecology)
Source: BJOG : An International Journal of Obstetrics and Gynaecology - June 12, 2020 Category: OBGYN Authors: Walker KF, O'Donoghue K, Grace N, Dorling J, Comeau JL, Li W, Thornton JG Tags: BJOG Source Type: research

Avoidable error in maternity care.
Abstract The UK media are increasingly highlighting concerns about the standard of midwifery and obstetric care in the National Health Service (NHS). A 2015 report into the standard of care provided by the University Hospitals of Morecambe Bay NHS Foundation Trust (https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/408480/47487_MBI_Accessible_v0.1.pdf) commented that "Clinical competence was substandard, with deficient skills and knowledge" and "there were failures of risk assessment and care planning that resulted in inappropriate and unsafe care". ...
Source: BJOG : An International Journal of Obstetrics and Gynaecology - June 10, 2020 Category: OBGYN Authors: Steer PJ Tags: BJOG Source Type: research

Hysterectomy as a treatment of endometriosis associated chronic pelvic pain.
Abstract Endometriosis related pain syndromes are associated with a reduction in the quality of life and an increase in the economic burden. (Simoens S et al Hum Reprod. 2012 May;27(5):1292-9) The relief from pelvic pain, following pelvic surgery for endometriosis associated with chronic pelvic pain which does not include hysterectomy, is often short term. For example, if surgery is limited to the excision of all visible lesions, recurrent symptoms requiring further surgery occur in 21% of the patients at 2 years and up to 55 % at 7 years. (Shakiba K et al Obstet Gynecol. 2008 Jun;111(6):1285-92) Long term post-op...
Source: BJOG : An International Journal of Obstetrics and Gynaecology - June 10, 2020 Category: OBGYN Authors: Falcone T Tags: BJOG Source Type: research

Pregnancy as a window to future health: what next?
Abstract The women's health paradigm has shifted in recent years. We have moved from considering pregnancy and its attendant complications as isolated events in a woman's life to viewing these as ongoing pertinent components of a woman's health history. Gestational diabetes and hypertensive disorders of pregnancy, in particular, are now recognized as markers of increased risk for cardiovascular and metabolic diseases among women later in life (Lane-Cordova AD et al, J Am Coll Cardiol, 2019, 73:2106-2116). Fetal growth restriction, placental abruption, stillbirth, and spontaneous preterm birth have also been identi...
Source: BJOG : An International Journal of Obstetrics and Gynaecology - June 8, 2020 Category: OBGYN Authors: Theilen LH Tags: BJOG Source Type: research

Better studies needed on LASER use in urinary incontinence.
Abstract LASERs are frequently marketed as a complication-free treatment for vaginal atrophy (genital syndrome of menopause [GSM]) and urinary incontinence (UI). At the same time, the disadvantages and risks of the standard options are overemphasized (i.e. topical oestrogens and risk of breast cancer; mid-urethral slings and risk of erosion, etc.). Less often, LASER is offered as an option for pelvic organ prolapse (POP) and vaginal looseness/laxity - the latter being a concept that was never objectively defined. PMID: 32506612 [PubMed - as supplied by publisher] (Source: BJOG : An International Journal of Ob...
Source: BJOG : An International Journal of Obstetrics and Gynaecology - June 7, 2020 Category: OBGYN Authors: Vieira-Baptista P Tags: BJOG Source Type: research

Reflex cytology for triage of high-risk human papillomavirus positive self-sampled material in cervical cancer screening: a prospective cohort study.
CONCLUSION: Cytology testing is achievable on hrHPV-positive self-samples, could decrease the loss to follow-up in screening and is easily implementable in the current clinical practice. Of all hrHPV-positive women with abnormal cytology on additional physician-collected samples, 26.4% could have been directly referred for colposcopy if triage with reflex cytology on self-sampled material was performed. PMID: 32506627 [PubMed - as supplied by publisher] (Source: BJOG : An International Journal of Obstetrics and Gynaecology)
Source: BJOG : An International Journal of Obstetrics and Gynaecology - June 7, 2020 Category: OBGYN Authors: Loopik DL, Melchers WJ, Vedder JE, van den Brule AJ, Massuger LF, Bekkers RL, Siebers AG Tags: BJOG Source Type: research

Understanding the effects of being SGA at birth.
Abstract Longitudinal neonatal outcome studies are becoming more exciting as we start to evaluate the trajectory of the well described sequelae of prematurity into the young adult effects of being born very preterm. In this issue of BJOG, Eves and colleagues use the Bavarian Longitudinal Study to evaluate the relative effects of being born small for gestational age (SGA) alongside important measures of social advantage and of parent infant relationship measures (BJOG 2020 xxxx). This is as it says - the effect of being small for dates at birth and not the effect of fetal growth restriction (FGR), an important dist...
Source: BJOG : An International Journal of Obstetrics and Gynaecology - June 5, 2020 Category: OBGYN Authors: Marlow N Tags: BJOG Source Type: research

Stop smoking for the next generation.
Abstract Pregnancy provides optimal opportunities for health promotion and disease prevention. Smoking before and during pregnancy is one of the largest modifiable risk factors for a range of adverse pregnancy outcomes. Concerns over the risks of smoking motivate many pregnant smokers to quit. However, most of their partners continue to smoke throughout pregnancy. More than one-third (35%) of men in the world smoke, and just over 6% of women do (Ritchie et al. Published online at OurWorldInData.org 2020). The impact of paternal smoking, second-hand or third-hand smoking on the perinatal health is largely overlooke...
Source: BJOG : An International Journal of Obstetrics and Gynaecology - June 3, 2020 Category: OBGYN Authors: Wang W, Duan T Tags: BJOG Source Type: research

Intrauterine versus external tocodynamometry in monitoring labour: A randomised controlled clinical trial.
CONCLUSIONS: IT did not reduce the rate of operative deliveries, use of oxytocin, or adverse neonatal outcomes, and it did not shorten labour duration. PMID: 32491233 [PubMed - as supplied by publisher] (Source: BJOG : An International Journal of Obstetrics and Gynaecology)
Source: BJOG : An International Journal of Obstetrics and Gynaecology - June 3, 2020 Category: OBGYN Authors: Hautakangas T, Uotila J, Huhtala H, Palomäki O Tags: BJOG Source Type: research

Authors' reply re: Mesh inlay, mesh kit or native tissue repair for women having repeat anterior or posterior prolapse surgery: randomised controlled trial (PROSPECT).
f Obstetrics and Gynaecology)
Source: BJOG : An International Journal of Obstetrics and Gynaecology - June 2, 2020 Category: OBGYN Authors: Authors' reply re: Mesh inlay, mesh kit or native tissue repair for women having repeat anterior or posterior prolapse surgery: randomised controlled trial (PROSPECT). Tags: BJOG Source Type: research

Preeclampsia-like syndrome induced by severe COVID-19: a prospective observational study.
CONCLUSIONS: Pregnant women with severe COVID-19 can develop a PE-like syndrome that might be distinguished from actual PE by sFlt-1/PlGF, LDH and UtAPI assessment. Health care providers should be aware of its existence and monitor pregnancies with suspected preeclampsia with caution. PMID: 32479682 [PubMed - as supplied by publisher] (Source: BJOG : An International Journal of Obstetrics and Gynaecology)
Source: BJOG : An International Journal of Obstetrics and Gynaecology - June 1, 2020 Category: OBGYN Authors: Mendoza M, Garcia-Ruiz I, Maiz N, Rodo C, Garcia-Manau P, Serrano B, Lopez-Martinez RM, Balcells J, Fernandez-Hidalgo N, Carreras E, Suy A Tags: BJOG Source Type: research

Vitamin D and stress urinary incontinence in pregnancy: a cross-sectional study.
nnessen HH Abstract OBJECTIVE: To assess the association between levels of vitamin D and urinary incontinence (UI) in pregnancy. DESIGN: A cross-sectional study. Secondary analysis of a randomised controlled trial. Setting Two university hospitals in Norway. Population 851 healthy, pregnant women>18 years in gestational week 18-22 with a singleton live fetus. METHODS: Data on UI were collected from a questionnaire at inclusion and serum analysis of 25-hydroxy vitamin D (25(OH)D) was performed. Univariable and multivariable logistic regression analyses were applied to study associations between exposur...
Source: BJOG : An International Journal of Obstetrics and Gynaecology - June 1, 2020 Category: OBGYN Authors: Nilssen Stafne S, Mørkved S, Gustafsson MK, Syversen U, Stunes AK, Salvesen KÅ, Johannessen HH Tags: BJOG Source Type: research

Small for Gestational Age - Cognitive Performance from Infancy to Adulthood: An Observational Study.
lke D Abstract OBJECTIVE: To determine whether cognitive performance from infancy to adulthood is affected by being born SGA, and if this depends on the SGA reference used. Furthermore, to determine SGA's effect while considering the effects of very preterm/very low birth weight (VP/VLBW), socioeconomic status (SES), and parent-infant relationship. DESIGN, SETTING AND POPULATION: 414 participants (197 Term-Born, 217 VP/VLBW) of the Bavarian Longitudinal Study METHODS: SGA was classified using neonatal or fetal growth references. SES and the parent-infant relationship were assessed before 5 months old. MA...
Source: BJOG : An International Journal of Obstetrics and Gynaecology - June 1, 2020 Category: OBGYN Authors: Eves R, Mendonça M, Bartmann P, Wolke D Tags: BJOG Source Type: research

Expectant Management is appropriate in some sIUGR monochorionic twins.
Abstract The paper by Colmant et al provides welcome new information on sIUGR (BJOG 2020 xxxx). The design is retrospective, single center, with 108 cases of type II sIUGR, with or without reversed or absent a-wave in the ductus venosus (DV)), over a 6 year period. Diagnosis was made before 26-6/7 weeks' and patients were presented with 2 interventions - selective fetoscopic laser coagulation (SFLC) or cord coagulation (CC) - as well as with expectant management (EM). Quoted pregnancy loss-risks were 15%, 20% and 30% respectively. PMID: 32479711 [PubMed - as supplied by publisher] (Source: BJOG : An Internati...
Source: BJOG : An International Journal of Obstetrics and Gynaecology - June 1, 2020 Category: OBGYN Authors: Belfort M Tags: BJOG Source Type: research

Retraction: Cervical mucus removal prior to intrauterine insemination: a randomized trial.
Authors: PMID: 32410398 [PubMed - in process] (Source: BJOG : An International Journal of Obstetrics and Gynaecology)
Source: BJOG : An International Journal of Obstetrics and Gynaecology - May 17, 2020 Category: OBGYN Tags: BJOG Source Type: research

Expression of concern: Nifedipine alone or combined with sildenafil citrate for management of threatened preterm labour: a randomised trial.
Authors: PMID: 32410400 [PubMed - in process] (Source: BJOG : An International Journal of Obstetrics and Gynaecology)
Source: BJOG : An International Journal of Obstetrics and Gynaecology - May 17, 2020 Category: OBGYN Tags: BJOG Source Type: research

The new normal.
PMID: 32410401 [PubMed - in process] (Source: BJOG : An International Journal of Obstetrics and Gynaecology)
Source: BJOG : An International Journal of Obstetrics and Gynaecology - May 17, 2020 Category: OBGYN Authors: Papageorghiou AT Tags: BJOG Source Type: research

Acupuncture for recurrent urinary tract infection in women: A systematic review and meta-analysis.
CONCLUSIONS: Acupuncture appeared to be beneficial for treatment and prophylaxis of rUTIs, noting the limitations of the current evidence. Given the growing challenge of antibiotic resistance, there is a need for high-quality RCTs of non-pharmacological interventions such as acupuncture. PMID: 32406571 [PubMed - as supplied by publisher] (Source: BJOG : An International Journal of Obstetrics and Gynaecology)
Source: BJOG : An International Journal of Obstetrics and Gynaecology - May 14, 2020 Category: OBGYN Authors: Qin X, Coyle ME, Yang L, Liang J, Wang K, Guo X, Zhang AL, Mao W, Lu C, Xue CC, Liu X Tags: BJOG Source Type: research

Impact of the size of the lesion in prenatal neural tube defect repair on imaging, neurosurgical and motor outcomes: a retrospective cohort study.
Abstract OBJECTIVES: (1) To compare brain findings between large and non-large neural tube defect (NTD); (2) To evaluate the impact of large lesion on the surgical parameters; (3) To study any associations between the size of the lesions and brain findings six weeks postoperatively, and neurological short-term outcomes. DESIGN: Retrospective cohort study SETTING: Texas Children's Hospital, between 2011 and 2018 POPULATION: Patients who underwent prenatal NTD repair METHODS: Large lesion was defined when the lesion's surface was greater than the 75th percentile of our cohorts' lesions. MAIN OUTCOME MEASUR...
Source: BJOG : An International Journal of Obstetrics and Gynaecology - May 14, 2020 Category: OBGYN Authors: Corroenne R, Zhu KH, Johnson E, Johnson R, Whitehead WE, Espinoza J, Castillo J, Castillo H, Orman G, Huisman TAGM, Mehollin-Ray AR, Shamshirsaz AA, Nassr AA, Belfort MA, Sanz Cortes M Tags: BJOG Source Type: research

Maternal haemodynamics: why should we care about it?
Abstract The interesting article published on this issue by Helen Perry et al (BJOG 2020 xxxx) is an important contribution to the idea demonstrated several years ago with echocardiographic evaluation of maternal central parameters, that the blood pressure value alone is not useful to understand the degree of compromise of maternal condition in the evaluation of gestational hypertension and preeclampsia (Valensise H et al. BJOG. 2006 Sep;113(9):1044-52. Epub 2006 Jul 7). PMID: 32407584 [PubMed - as supplied by publisher] (Source: BJOG : An International Journal of Obstetrics and Gynaecology)
Source: BJOG : An International Journal of Obstetrics and Gynaecology - May 14, 2020 Category: OBGYN Authors: Valensise H Tags: BJOG Source Type: research

Cephalic extraction versus breech extraction in second stage cesarean section: a retrospective study.
Abstract OBJECTIVE: Our primary objective was to compare maternal and neonatal outcomes based on the attempted mode of extraction. Our secondary objective was to compare the outcomes based on the actual mode of extraction. DESIGN: A retrospective cohort study at a single tertiary center between the years 2011 and 2019. SETTING: The study included 1028 cases of term pregnancies in vertex presentation that were delivered by cesarean section at the second stage of delivery. POPULATION: Patients were grouped according to the attempted mode of extraction: attempted cephalic extraction (674) and breech ex...
Source: BJOG : An International Journal of Obstetrics and Gynaecology - May 13, 2020 Category: OBGYN Authors: Ezra O, Lahav-Ezra H, Meyer R, Cahan T, Ilan H, Mazaki-Tovi S, Sivan E, Barzilay E, Haas J Tags: BJOG Source Type: research

Re: Antenatal magnesium sulphate for the prevention of cerebral palsy in infants born preterm: a double-blind, randomised, placebo-controlled, multi-centre trial: At which gestational ages should magnesium sulphate be given to women at risk of preterm birth?
PMID: 32394601 [PubMed - as supplied by publisher] (Source: BJOG : An International Journal of Obstetrics and Gynaecology)
Source: BJOG : An International Journal of Obstetrics and Gynaecology - May 11, 2020 Category: OBGYN Authors: Larsen ML, Krebs L, Rackauskaite G, Hoei-Hansen CE, Greisen G Tags: BJOG Source Type: research

Re: Universal screening versus risk-based protocols for antibiotic prophylaxis during childbirth to prevent early-onset group B streptococcal disease: a systematic review and meta-analysis.
PMID: 32388903 [PubMed - as supplied by publisher] (Source: BJOG : An International Journal of Obstetrics and Gynaecology)
Source: BJOG : An International Journal of Obstetrics and Gynaecology - May 10, 2020 Category: OBGYN Authors: Seedat F, Marshall J Tags: BJOG Source Type: research

Powerful evidence on HELLP syndrome from a routine health database.
Abstract Hypertension associated with pregnancy is the first or second contributor to the burden of maternal death and severe maternal morbidity, depending on the income level of the heath care setting (WHO, Maternal mortality: Levels and trends, 2000 to 2017. Geneva: WHO, 2019). Although its pathophysiology is still not fully understood and it is relatively uncommon, HELLP syndrome is one of the most severe hypertensive disorders of pregnancy. Due to its relatively low prevalence rate, data regarding frequency, risk factors and associated maternal and perinatal outcomes are limited to small series from individual...
Source: BJOG : An International Journal of Obstetrics and Gynaecology - May 9, 2020 Category: OBGYN Authors: Cecatti JG Tags: BJOG Source Type: research

Performance of a risk score for predicting preterm pre-eclampsia.
Abstract Brunelli et al (BJOG 2020) evaluated a previously validated maternal history -based risk score in a multicentric retrospective cohort from Italy. The risk score discriminated poorly in this study (AUC=0.659 [95% CI 0.579-0.726]) but it discriminated well in the Pregnancy Outcome Prediction (POP) study (AUC=0.846 [95% CI 0.787-0.906]) (Sovio et al, BJOG 2019;126:963-970), although the proportion of women who developed preterm pre-eclampsia was similar in both studies (1.0% and 0.7%, respectively). What could be the possible reasons for these differences and what should be the next steps for evaluating such...
Source: BJOG : An International Journal of Obstetrics and Gynaecology - May 8, 2020 Category: OBGYN Authors: Sovio U Tags: BJOG Source Type: research

Association of maternal attention deficit hyperactivity disorder and preterm birth: a cohort study.
ml;m AK Abstract OBJECTIVE: Attention deficit hyperactivity disorder (ADHD) affects 3-7% of women of childbearing age. Whether ADHD is associated with an increased risk of preterm birth is unclear. DESIGN: National register-based cohort study. SETTING: Sweden. POPULATION: Nulliparous women giving birth to singleton infants 2007-2014 (n = 377,381). METHODS: Women were considered to have ADHD if they had been dispensed at least one prescription for ADHD medication, i.e., a central nervous system stimulant or non-stimulant drugs for ADHD, prior to, during or after pregnancy (2005-2014). Women...
Source: BJOG : An International Journal of Obstetrics and Gynaecology - May 8, 2020 Category: OBGYN Authors: Hesselman S, Wikman A, Skoglund C, Kopp Kallner H, Skalkidou A, Sundström-Poromaa I, Wikström AK Tags: BJOG Source Type: research

Maternal ADHD and preterm birth: interpret with care.
Abstract A note of caution is advised on the definition of a woman considered to have ADHD at some time-point before, during or post pregnancy. In the reported study women were considered to have had an episode of ADHD if they were dispensed a prescription for an ADHD medication (Hesselman et al. BJOG 2020 xxxx). This will not be as accurate as a clinical diagnosis of the condition. Dispensing medication depends on the women presenting the prescription at a pharmacy, which is not always the case when mental health issues are prevalent. PMID: 32384217 [PubMed - as supplied by publisher] (Source: BJOG : An Inte...
Source: BJOG : An International Journal of Obstetrics and Gynaecology - May 8, 2020 Category: OBGYN Authors: Lane S Tags: BJOG Source Type: research

Incidence and characteristics of pregnancy-related death across ten low and middle-income geographical regions: secondary analysis of a cluster randomised controlled trial.
CONCLUSIONS: The large variation in rate of pregnancy-related death, irrespective of resource availability, emphasizes that inequality and inequity in health care persists. PMID: 32383337 [PubMed - as supplied by publisher] (Source: BJOG : An International Journal of Obstetrics and Gynaecology)
Source: BJOG : An International Journal of Obstetrics and Gynaecology - May 7, 2020 Category: OBGYN Authors: Vousden N, Holmes E, Seed PT, Gidiri MF, Goudar S, Sandall J, Chinkoyo S, Kumsa LY, Brown A, Charantimath U, Bellad M, Nakimuli A, Vwalika B, Chappell LC, Shennan AH, CRADLE Trial Collaborative Group Tags: BJOG Source Type: research

Interpregnancy interval and risk of perinatal death: a systematic review and meta-analysis.
Abstract BACKGROUND: Interpregnancy interval (IPI)
Source: BJOG : An International Journal of Obstetrics and Gynaecology - May 7, 2020 Category: OBGYN Authors: Regan AK, Arnaout A, Marinovich L, Marston C, Patino I, Kaur R, Gebremedhin A, Pereira G Tags: BJOG Source Type: research

Touch in the Era of COVID-19.
Abstract I moved out of our shared bedroom of nearly 10 years on 3/22/2020. It was not a difficult decision as we have two young children and wondered what would happen if both of us became ill at the same time. As a Maternal-Fetal medicine physician in New York City, I was acutely aware of the coming COVID-19 crisis, and its potential ramifications on the health of my family, friends, patients and community. I am trained to function well in emergencies, and in this case, it was a quick and seemingly logical next-step to sleep separately. PMID: 32378288 [PubMed - as supplied by publisher] (Source: BJOG : An I...
Source: BJOG : An International Journal of Obstetrics and Gynaecology - May 7, 2020 Category: OBGYN Authors: Mehta-Lee SS Tags: BJOG Source Type: research