Red cell index: A novel biomarker for 3 ‐month mortality in acute ischemic stroke patients treated with intravenous thrombolysis
This is the first article on the prognostic value of red cell index in AIS patients treated with r ‐tPA. There is no correlation between red cell index and 3‐month poor outcome. Red cell index is significantly associated with 3‐month mortality.​ AbstractBackgroundThe red cell index (RCI) was described as a biomarker for evaluating respiratory function in previous studies, but the relationship between RCI and stroke, remained a mystery. The present study aimed to probe the association between RCI at 24 ‐hr and 3‐month mortality and functional outcomes among acute ischemic stroke (AIS) patients treated with recom...
Source: Brain and Behavior - May 4, 2021 Category: Neurology Authors: Meizi Qian, Xinbo Zhou, Beibei Gao, Honghao Huang, Chenguang Yang, Tian Zeng, Jiamin Shen, Jingyu Hu, Fangyue Sun, Shengqi Li, Xuerong Huang, Guangyong Chen Tags: ORIGINAL RESEARCH Source Type: research

HiCommunication as a novel speech and communication treatment for Parkinson's disease: A feasibility study
ConclusionsResults indicate that HiCommunication is feasible for people with mild ‐moderate PD. The program was appreciated and well tolerated. Positive outcomes regarding voice sound level and intelligibility were observed; however, the number of participants was very limited. The results motivate that effects of HiCommunication are further studied in a randomized controlled t rial, which is ongoing. (Source: Brain and Behavior)
Source: Brain and Behavior - May 4, 2021 Category: Neurology Authors: Ellika Schalling, Helena Winkler, Erika Franz én Tags: ORIGINAL RESEARCH Source Type: research

Impairment of eye emotion discrimination in benign childhood epilepsy with centrotemporal spikes: A neuropsychological study
ConclusionsIn our study, newly diagnosed BECT patients exhibited emotion discrimination dysfunction, mainly related to sadness, fear, and disgust, and this dysfunction was more severe the younger the age of onset was. However, after BECT remission, the ability to discriminate emotions returned to normal. (Source: Brain and Behavior)
Source: Brain and Behavior - May 4, 2021 Category: Neurology Authors: Lulu Wu, Xinyu Yang, Kaili Zhang, Xiaocui Wang, Bin Yang Tags: ORIGINAL RESEARCH Source Type: research

LncRNA GAS8 ‐AS1 downregulates lncRNA NEAT1 to inhibit glioblastoma cell proliferation
ConclusionOverexpression of GAS8 ‐AS1 inhibits GBM cell proliferation and invasion by downregulating NEAT1. (Source: Brain and Behavior)
Source: Brain and Behavior - May 4, 2021 Category: Neurology Authors: Xiaoming Wu, Tingting Jiang, Rui Huang, Xue Xiao Tags: ORIGINAL RESEARCH Source Type: research

Program development using intervention mapping in primary healthcare settings to address elder abuse: A randomized controlled pilot study
A culturally informed treatment, based on Intervention Mapping (IM), for primary healthcare settings was developed. The intervention targets family members of elderly women and seeks to reduce elder abuse. The intervention reduced psychological abuse and neglect. Physical abuse occurred at very low rates. Implementation and further testing in healthcare facilities are recommended. AbstractBackgroundAbuse of elderly women is of great concern and yet relatively little is known about interventions.ObjectivesThe aim of this study was to develop and test a culturally informed treatment, based on Intervention Mapping (IM), for p...
Source: Brain and Behavior - May 4, 2021 Category: Neurology Authors: Sonia Oveisi, LAR Stein, Forozan Olfati, Shima Jahed Tags: ORIGINAL RESEARCH Source Type: research

Atrial cardiopathy in embolic stroke of undetermined source
ConclusionsThe incidence of sLAE was higher in ESUS patients than in patients with noncardioembolic strokes. AC ‐ESUS was milder when compared to AF‐CE stroke. (Source: Brain and Behavior)
Source: Brain and Behavior - May 4, 2021 Category: Neurology Authors: Jing Chen, Fenglian Gao, Wenhong Liu Tags: ORIGINAL RESEARCH Source Type: research

Risk factors for early –onset seizures after stroke: A systematicreview and meta‐analysis of 18 observational studies
These findings suggest that cortical involvement, intracerebral hemorrhage and cerebral infarction with hemorrhagic transformation are important predictors and risk factors for early seizures after stroke, while the patient's gender, age, NHISS score, alcoholism, smoking, high blood pressure, diabetes, atrial fibrillation, dyslipidemia , receiving surgical treatment and reperfusion therapy showed no association with the occurrence of early ‐onset seizures after stroke. AbstractObjectivesTo systematically evaluate the risk factors of early ‐onset seizures after stroke, in order to better provide evidence‐based results...
Source: Brain and Behavior - May 4, 2021 Category: Neurology Authors: Sitian Ma, Xiaoxuan Fan, Xiaoping Zhao, Kai Wang, Huan Wang, Yongfeng Yang Tags: ORIGINAL RESEARCH Source Type: research

When reintegration fails: Stigmatization drives the ongoing violence of ex ‐combatants in Eastern Democratic Republic of the Congo
This article showed that stigmatization presents as additional burden for ex ‐combatants in Eastern DRC beyond posttraumatic experiences. Rejective attitudes toward ex‐combatants form the basis of stigmatization and by predicting both mental health problems and aggression present as social drivers of the cycles of violence. Our study demonstrates the importance for inter vention programming that combines individual treatment with interventions including ex‐combatants' social environment. AbstractReintegration of ex ‐combatants involves multiple challenges. In addition to the trauma‐related psychological sequelae,...
Source: Brain and Behavior - May 4, 2021 Category: Neurology Authors: Sabine Schmitt, Katy Robjant, Anke Koebach Tags: ORIGINAL RESEARCH Source Type: research

Monocyte ‐to‐lymphocyte ratio as a predictor of stroke‐associated pneumonia: A retrospective study‐based investigation
Monocyte to lymphocyte ratio (MLR) have been proposed as indicators of systemic inflammation and infection. However, none studies have focused on the predictive value of MLR for SAP. We investigated the predictive value of MLR for SAP and to investigate their relationship with disease severity. AbstractBackground and purposeEarly prediction of stroke ‐associated pneumonia (SAP) is significant in clinical practice, as it is frequently challenging due to delays in typical clinical manifestations and radiological changes. The monocyte‐to‐lymphocyte ratio (MLR) has been proposed as an indicator of systemic inflammation a...
Source: Brain and Behavior - May 4, 2021 Category: Neurology Authors: Feng Cao, Yu Wan, Chunyan Lei, LianMei Zhong, HongTao Lei, Haimei Sun, Xing Zhong, YaDan Xiao Tags: ORIGINAL RESEARCH Source Type: research

Embryonic ethanol exposure on zebrafish early development
ConclusionsOur results suggest any ethanol exposure during embryogenesis can be harmful and reinforces zebrafish as a suitable model for fetal alcohol spectrum disorders (FASD). (Source: Brain and Behavior)
Source: Brain and Behavior - May 4, 2021 Category: Neurology Authors: Jaquelinne Pinheiro ‐da‐Silva, Ana Carolina Luchiari Tags: ORIGINAL RESEARCH Source Type: research

Safety and efficacy of intravenous thrombolytic treatment in wake ‐up stroke: Experiences from a single center
ConclusionsOur study demonstrated that in patients who awaken with stroke symptoms, intravenous thrombolytic treatment is a safe procedure that may lead to favorable outcomes. Further studies should be performed to increase the size of the group of patients with wake ‐up strokes who can be treated with reperfusion therapy. (Source: Brain and Behavior)
Source: Brain and Behavior - May 3, 2021 Category: Neurology Authors: Adam Wi śniewski Tags: ORIGINAL RESEARCH Source Type: research

Psychiatric risk and resilience: Plasticity genes and positive mental health
ConclusionsResults provided support for extending the ARMS construct, pointing to important contributions of personality, social cognition, and genes that support neural plasticity in mitigating vulnerability and enhancing resilience and well ‐being. (Source: Brain and Behavior)
Source: Brain and Behavior - May 1, 2021 Category: Neurology Authors: Paul G. Nestor, Victoria Choate Hasler, Keira O'Donovan, Hannah E. Lapp, Sara B. Boodai, Richard Hunter Tags: ORIGINAL RESEARCH Source Type: research

Can seizure therapies and noninvasive brain stimulations prevent suicidality? A systematic review
ConclusionsFuture enquiry is necessary to address methodological limitations and evaluate the long ‐term efficacy of these methods both alone and in combination with pharmacotherapy and/or psychotherapy. (Source: Brain and Behavior)
Source: Brain and Behavior - April 10, 2021 Category: Neurology Authors: Yiming Chen, Charline Magnin, J érome Brunelin, Edouard Leaune, Yiru Fang, Emmanuel Poulet Tags: REVIEW Source Type: research

Exposure to DMSO during infancy alters neurochemistry, social interactions, and brain morphology in long ‐evans rats
Summary of cellular and metabolic brain changes following brief exposure to DMSO. AbstractIntroductionDimethyl sulfoxide (DMSO) is a widely used solvent to dissolve hydrophobic substances for clinical uses and experimental in vivo purposes. While usually regarded safe, our prior studies suggest changes to behavior following DMSO exposure. We therefore evaluated the effects of a five ‐day, short‐term exposure to DMSO on postnatal infant rats (P6‐10).MethodsDMSO was intraperitoneally injected for five days at 0.2, 2.0, and 4.0  ml/kg body mass. One cohort of animals was sacrificed 24 hr after DMSO exposure to...
Source: Brain and Behavior - April 10, 2021 Category: Neurology Authors: Zachary Rabow, Taryn Morningstar, Megan Showalter, Hailey Heil, Krista Thongphanh, Sili Fan, Joanne Chan, Ver ónica Martínez‐Cerdeño, Robert Berman, David Zagzag, Evgeny Nudler, Oliver Fiehn, Mirna Lechpammer Tags: ORIGINAL RESEARCH Source Type: research

Issue Information
(Source: Brain and Behavior)
Source: Brain and Behavior - April 10, 2021 Category: Neurology Tags: ISSUE INFORMATION Source Type: research

Cortical morphometric changes associated with completeness, level, and duration of spinal cord injury in humans: A case –control study
ConclusionsThe study provided imaging evidence for identifying cerebral structural abnormalities in SCI patients and significant differences in complete/incomplete and paraplegia/tetraplegia subgroups. These results suggested brain structural changes occur after SCI and these changes may depend on the injury completeness, level, and duration. (Source: Brain and Behavior)
Source: Brain and Behavior - April 10, 2021 Category: Neurology Authors: Yun Guo, Feng Gao, Hua Guo, Weiyong Yu, Zhenbo Chen, Mingliang Yang, Degang Yang, Liangjie Du, Jianjun Li Tags: ORIGINAL RESEARCH Source Type: research

Characteristics associated with the risk of psychosis among immigrants and their descendants in France
ConclusionThe current study shows that the increased risk of psychosis in groups with an immigration background in France is associated with their origin and highlights the importance of socioeconomic factors in modulating this risk. (Source: Brain and Behavior)
Source: Brain and Behavior - April 9, 2021 Category: Neurology Authors: Andrea Tortelli, Patrick Simon, Sophie Lehouelleur, Norbert Skurnik, Jean Romain Richard, Gr égoire Baudin, Aziz Ferchiou, Marion Leboyer, Franck Schürhoff, Andrei Szöke Tags: ORIGINAL RESEARCH Source Type: research

Association of Brain ‐Derived Neurotrophic Factor rs6265 G > A polymorphism and Post ‐traumatic Stress Disorder susceptibility: A systematic review and meta‐analysis
ConclusionCurrent meta ‐analysis suggests that theBDNF rs6265  G >  A polymorphism might be involved in PTSD susceptibility. (Source: Brain and Behavior)
Source: Brain and Behavior - April 9, 2021 Category: Neurology Authors: Xi ‐Yi Hu, Yu‐Long Wu, Chao‐Hui Cheng, Xiao‐Xi Liu, Lan Zhou Tags: ORIGINAL ARTICLE Source Type: research

Estrogen attenuates physical and psychological stress ‐induced cognitive impairments in ovariectomized rats
In this study, we investigated whether two different models of stress act differently on ovariectomized (OVX) rats and the impact of estrogen on physical or psychological stress ‐induced impairments in cognitive‐behaviors. Adult female Wistar rats at 21–22 weeks of age were utilized for this investigation. Sham and OVX rats were subjected to physical and psychological stress for 1 hr/day for 7 days, and cognitive performance was assessed using morris water maze (MW M) and passive avoidance (PA) tests. The open field and elevated plus maze tests (EPM) evaluated exploratory and anxiety‐like behavio...
Source: Brain and Behavior - April 6, 2021 Category: Neurology Authors: Mina Khaleghi, Mohammad Amin Rajizadeh, Hamideh Bashiri, Kristi Anne Kohlmeier, Fatemeh Mohammadi, Mohammad Khaksari, Mohammad Shabani Tags: ORIGINAL RESEARCH Source Type: research

Human liver ‐expressed antimicrobial peptide 2 elevation in the cerebrospinal fluid in bacterial meningitis
This original study describes the identification of liver ‐expressed antimicrobial peptide 2 (LEAP2), an antimicrobial peptide, in human CSF, and is the first to measure CSF LEAP2 in neurological disorders. CSF LEAP2 is increased in patients with bacterial meningitis, suggesting its biological significance in the pathology of CNS infections. AbstractObjectiveTo study the presence of liver ‐expressed antimicrobial peptide 2 (LEAP2) in human cerebrospinal fluid (CSF) and to measure its concentrations in neurological disorders.Materials& MethodsWe identified the presence of LEAP2 in human CSF by chromatographic analys...
Source: Brain and Behavior - April 3, 2021 Category: Neurology Authors: Katsuya Sakai, Kazutaka Shiomi, Hitoshi Mochizuki, Md Nurul Islam, Hiroki Nabekura, Ryota Tanida, Hideyuki Sakoda, Masamitsu Nakazato Tags: ORIGINAL RESEARCH Source Type: research

A mediating role for mental health in associations between COVID ‐19‐related self‐stigma, PTSD, quality of life, and insomnia among patients recovered from COVID‐19
This study examined mental health as a potential mediating factor linking self‐stigmatization and PTSD to quality of life and sleep.MethodsUsing a cross ‐sectional design, 844 people who had recovered from COVID‐19 were called and interviewed. Data were collected using structured scales. Structural equation modeling was applied to assess fitness of a mediation model including self‐stigma and PTSD as independent factors and quality of life and insomnia as dependent variables.ResultsMental health, COVID ‐19‐related self‐stigma, and mental quality of life were associated. Insomnia, PTSD, and COVID‐19‐related...
Source: Brain and Behavior - April 3, 2021 Category: Neurology Authors: Hosein Mahmoudi, Mohsen Saffari, Mahmoud Movahedi, Hormoz Sanaeinasab, Hojat Rashidi ‐Jahan, Morteza Pourgholami, Ali Poorebrahim, Jalal Barshan, Milad Ghiami, Saman Khoshmanesh, Marc N. Potenza, Chung‐Ying Lin, Amir H. Pakpour Tags: ORIGINAL RESEARCH Source Type: research

Maternal immune activation alters adult behavior, intestinal integrity, gut microbiota and the gut inflammation
ConclusionsMaternal immune activation alters behavior, intestinal integrity, gut microbiota and the gut inflammation in adult offspring. (Source: Brain and Behavior)
Source: Brain and Behavior - April 1, 2021 Category: Neurology Authors: Wenqiang Li, Mengxue Chen, Xia Feng, Meng Song, Minglong Shao, Yongfeng Yang, Luwen Zhang, Qing Liu, Luxian Lv, Xi Su Tags: ORIGINAL RESEARCH Source Type: research

Structural connectivity networks in Alzheimer ’s disease and Lewy body disease
ConclusionConcomitant ADCI and LBCI are associated with the accentuation of LBCI ‐related WM network disruption centered in the left caudate nucleus. The increase of occipital betweenness centrality could be a characteristic biologic change associated with visuospatial dysfunction in LBCI. (Source: Brain and Behavior)
Source: Brain and Behavior - April 1, 2021 Category: Neurology Authors: Kyoungwon Baik, Jin ‐Ju Yang, Jin Ho Jung, Yang Hyun Lee, Seok Jong Chung, Han Soo Yoo, Young H. Sohn, Phil Hyu Lee, Jong‐Min Lee, Byoung Seok Ye Tags: ORIGINAL RESEARCH Source Type: research

Optical coherence tomography angiography helps distinguish multiple sclerosis from AQP4 ‐IgG‐seropositive neuromyelitis optica spectrum disorder
In summary, our study compared the structure and flow between patients with MS and those with AQP4 ‐IgG‐positive NMOSD, indicating pathophysiological differences between them and suggesting that OCTA may have an additive effect as a biomarker in conjunction with routine OCT measurements. Combining OCTA and OCT may yield promising diagnostic properties in distinguishing both diseases. AbstractIntroductionThe aim was to characterize the optical coherence tomography (OCT) angiography measures in patients with multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD) and to evaluate their disease discrimin...
Source: Brain and Behavior - March 30, 2021 Category: Neurology Authors: Chunxin Liu, Hui Xiao, Xiayin Zhang, Yipeng Zhao, Rui Li, Xiaonan Zhong, Yuge Wang, Yaqing Shu, Yanyu Chang, Jingqi Wang, Caixia Li, Haotian Lin, Wei Qiu Tags: ORIGINAL RESEARCH Source Type: research

Complications following REM sleep behavior disorder
REM sleep behavior disorder (RBD) is gaining increasing attention as important prodromal marker for the development of neurodegenerative disorders such as Parkinson's Disease. However, the clinical relevance of this disorder and its association with other prodromal markers is often underestimated in clinical routine. We here report a case of severe clinical complications following extensive nocturnal movements due to RBD, aggravated by occurrence of additional prodromal nonmotor symptoms. AbstractREM sleep behavior disorder (RBD) is gaining increasing attention as important prodromal marker for the development of neurodege...
Source: Brain and Behavior - March 30, 2021 Category: Neurology Authors: Eva Schaeffer, Daniela Berg Tags: ORIGINAL ARTICLE Source Type: research

The impact of TMS ‐enhanced cognitive control on forgiveness processes
ConclusionAs an explanation it is discussed that the TBS can only affect “cold” emotions such as greed, but not the “hot” emotions such as anger. (Source: Brain and Behavior)
Source: Brain and Behavior - March 30, 2021 Category: Neurology Authors: Moritz J. Maier, David Rosenbaum, Martin Br üne, Andreas J. Fallgatter, Ann‐Christine Ehlis Tags: ORIGINAL RESEARCH Source Type: research

Characterizing resting ‐state networks in Parkinson’s disease: A multi‐aspect functional connectivity study
ConclusionWe found various characteristics of the alteration of the RSNs in PD patients compared with HCs. Our results suggest that different characteristics of RSNs provide insights into the biological mechanism of PD. (Source: Brain and Behavior)
Source: Brain and Behavior - March 30, 2021 Category: Neurology Authors: Mahdieh Ghasemi, Ali Foroutannia, Abbas Babajani ‐Feremi Tags: ORIGINAL RESEARCH Source Type: research

Working memory in schizophrenia: The role of the locus coeruleus and its relation to functional brain networks
In the present study, we sought to shed further light on the role of the LC ‐NE system in patients with schizophrenia. We found the LC‐NE system to be crucial in modulating neuronal network activity in a 3‐back working memory task in schizophrenia. AbstractEvidence suggests functional brain networks, especially the executive control network (ECN) and default mode network (DMN), to be abnormal in schizophrenia. Dysfunctions within the locus coeruleus (LC) ‐noradrenaline (NE) system, which is supposed to be pivotal to modulate neuronal network activation during executive control (e.g., working memory function), are a...
Source: Brain and Behavior - March 30, 2021 Category: Neurology Authors: Stefanie Suttkus, Andy Schumann, Feliberto Cruz, Karl ‐Jürgen Bär Tags: ORIGINAL RESEARCH Source Type: research

Cerebral glucose metabolism in bipolar disorder: A voxel ‐based meta‐analysis of positron emission tomography studies
ConclusionsCerebral glucose metabolism alterations in these brain regions are likely to reflect the disease ‐related functional abnormalities such as emotion and cognition. These findings contribute to a better understanding of the neurobiological underpinnings of bipolar disorder.Limitations.This study was done at a study level and cannot be addressed at the patient level. Subgroup analysis of BD I and BD II is not possible due to limited literature data. (Source: Brain and Behavior)
Source: Brain and Behavior - March 30, 2021 Category: Neurology Authors: Chujun Wu, Chutong Ren, Ziwei Teng, Sujuan Li, Floyd Silva, Haishan Wu, Jindong Chen Tags: ORIGINAL RESEARCH Source Type: research

Entorhinal cortex and parahippocampus volume reductions impact olfactory decline in aged subjects
ConclusionOur results indicate that olfactory decline may be directly reflected in the medial temporal regions as reduced parahippocampus volumes, rather than as morphological changes in the entorhinal cortex and hippocampus. The parahippocampus may play an important role in the association between memory retrieval and olfactory identification. (Source: Brain and Behavior)
Source: Brain and Behavior - March 26, 2021 Category: Neurology Authors: Natsuko Iizuka, Yuri Masaoka, Satomi Kubota, Haruko Sugiyama, Masaki Yoshida, Akira Yoshikawa, Nobuyoshi Koiwa, Motoyasu Honma, Keiko Watanabe, Shotaro Kamijo, Sawa Kamimura, Masahiro Ida, Kenjiro Ono, Masahiko Izumizaki Tags: ORIGINAL RESEARCH Source Type: research

Changes in the anterior cingulate cortex in Crohn ’s disease: A neuroimaging perspective
ConclusionsFor patients with CD, the ACC demonstrates structural, functional, and metabolic changes. In terms of clinical findings, the ACC plays an important role in the onset of depression/anxiety and abdominal pain. Therefore, successful modulation of this pathway may guide treatment. (Source: Brain and Behavior)
Source: Brain and Behavior - March 26, 2021 Category: Neurology Authors: Ning Kong, Chen Gao, Maosheng Xu, Xuning Gao Tags: REVIEW Source Type: research

Issue Information
(Source: Brain and Behavior)
Source: Brain and Behavior - March 26, 2021 Category: Neurology Tags: ISSUE INFORMATION Source Type: research

Zonisamide effects on sleep problems and depressive symptoms in Parkinson ’s disease
ConclusionWe showed the beneficial effects of ZNS on motor symptoms and sleep problems in levodopa ‐treated PD patients with motor fluctuation. ZNS may be more effective for several nonmotor symptoms in PD patients with tremor compared with those without tremor. (Source: Brain and Behavior)
Source: Brain and Behavior - March 26, 2021 Category: Neurology Authors: Keisuke Suzuki, Hiroaki Fujita, Takeo Matsubara, Yasuo Haruyama, Taro Kadowaki, Kei Funakoshi, Yuji Watanabe, Koichi Hirata Tags: ORIGINAL RESEARCH Source Type: research

Burnout, depersonalization, and anxiety contribute to post ‐traumatic stress in frontline health workers at COVID‐19 patient care, a follow‐up study
ConclusionsPre ‐existent anxiety/depression, dissociative symptoms, and coexisting acute anxiety and acute stress contribute to PTSD symptoms. During an infectious outbreak, psychological screening could provide valuable information to prevent or mitigate against adverse psychological reactions by frontline heal thcare workers caring for patients. (Source: Brain and Behavior)
Source: Brain and Behavior - March 26, 2021 Category: Neurology Authors: Jos é Adán Miguel‐Puga, Davis Cooper‐Bribiesca, Francisco José Avelar‐Garnica, Luis Alejandro Sanchez‐Hurtado, Tania Colin‐Martínez, Eliseo Espinosa‐Poblano, Juan Carlos Anda‐Garay, Jorge Iván González‐Díaz, Oscar Bernardo S Tags: ORIGINAL RESEARCH Source Type: research

Callosal abnormalities, altered cortisol levels, and neurocognitive deficits associated with early maltreatment among adolescents: A voxel ‐based diffusion‐tensor imaging study
In our study, objective measures of childhood maltreatment were associated with abnormal white matter microstructure in posterior regions of the CC (splenium), and correlated with specific neurocognitive impairments and abnormal cortisol levels. AbstractIntroductionNeuroimaging studies have shown callosal abnormalities among maltreated subjects, but little is known about the functional and neurobiological correlates of these supposed developmental alterations. The aim of this study was to investigate childhood maltreatment (CM), neurocognitive functioning, cortisol levels, and corpus callosum (CC) integrity among adolescen...
Source: Brain and Behavior - March 26, 2021 Category: Neurology Authors: Paulo Jannuzzi Cunha, Fabio L.S. Duran, Paula Approbato Oliveira, Tiffany M. Chaim ‐Avancini, Ana Luiza V. Milioni, Mariella Ometto, Paula Squarzoni, Pedro P. Santos, Sheila C. Caetano, Geraldo F. Busatto, Sandra Scivoletto Tags: ORIGINAL RESEARCH Source Type: research

Mapping the orbitofrontal cortex using temporal fluctuations in cerebral blood flow
ConclusionTo our knowledge, this constitutes the first in vivo cortical parcellation based on perfusion fluctuations. Our approach confirms functional OFC subdivisions predicted from anatomy using a less susceptibility ‐sensitive method than the conventional approach. (Source: Brain and Behavior)
Source: Brain and Behavior - March 26, 2021 Category: Neurology Authors: Kalen J. Petersen, Manus J. Donahue, Daniel O. Claassen Tags: ORIGINAL RESEARCH Source Type: research

Phenotypic characterization of frontal cortex microglia in a rat model of post ‐traumatic stress disorder
ConclusionPsychological trauma impacts the immunological phenotype of microglia of the frontal cortex. Consequently, future studies should further evaluate the mechanistic role of microglia in PTSD pathology. (Source: Brain and Behavior)
Source: Brain and Behavior - March 26, 2021 Category: Neurology Authors: Thomas S. Cotrone, Charina B. Hocog, Joseph T. Ramsey, Marcus A. Sanchez, Heather M. Sullivan, Angus G. Scrimgeour Tags: ORIGINAL RESEARCH Source Type: research

A cross ‐sectional survey on occupational stress and associated dyslipidemia among medical staff in tertiary public hospitals in Wenzhou, China
ConclusionsThe occupational stress level of medical staff in tertiary public hospitals in Wenzhou was high, and occupational stress may contribute to dyslipidemia. An investigation into occupational stress levels and their association with dyslipidemia in this population could draw more attention to medical staff in tertiary public hospitals. (Source: Brain and Behavior)
Source: Brain and Behavior - March 26, 2021 Category: Neurology Authors: Hui Zhang, Meng ‐Meng Shao, Xian‐Da Lin, Li‐Jun Cheng, Begench Ovlyakulov, Bo‐Bei Chen, Ke‐Yang Chen Tags: ORIGINAL RESEARCH Source Type: research

Brain network construction and analysis for patients with mild cognitive impairment and Alzheimer's disease based on a highly ‐available nodes approach
ConclusionsThe findings of this study provide insights for helping understanding the progress of the AD. The proposed method highlights the effectively representative time series of brain regions of rs ‐fMRI data for construction and topology analysis brain network. (Source: Brain and Behavior)
Source: Brain and Behavior - March 26, 2021 Category: Neurology Authors: Xiaopan Zhang, Junhong Liu, Yuan Chen, Yanan Jin, Jingliang Cheng, for the Alzheimer ’s Disease Neuroimaging Initiative Tags: ORIGINAL RESEARCH Source Type: research

Lifetime psychiatric hospital diagnoses among 8,412 Danish men registered in an outpatient alcohol clinic
ConclusionAmong men with a lifetime psychiatric hospital diagnosis, AUD is rarely diagnosed without psychiatric comorbidity at first ‐time admissions to psychiatric hospital departments. (Source: Brain and Behavior)
Source: Brain and Behavior - March 26, 2021 Category: Neurology Authors: Lea A. N. Christoffersen, Erik L. Mortensen, Merete Osler, Holger J. S ørensen, Ulrik Becker, Trine Flensborg‐Madsen Tags: ORIGINAL RESEARCH Source Type: research

Psychological impact of COVID ‐19 pandemic on healthcare workers in China Xi’an central hospital
ConclusionsThe COVID ‐19 pandemic has increased psychological stress among healthcare workers with 10 years or more work experiences and who recently experienced a career position change. (Source: Brain and Behavior)
Source: Brain and Behavior - March 26, 2021 Category: Neurology Authors: Nan Wang, Yongqin Li, Qiaoxia Wang, Caihong Lei, Yuanyuan Liu, Shanshan Zhu Tags: ORIGINAL RESEARCH Source Type: research

The error ‐related negativity as a neuromarker of risk or resilience in young children
ConclusionsThese results can inform identification and intervention efforts for children at risk for psychopathology. (Source: Brain and Behavior)
Source: Brain and Behavior - March 26, 2021 Category: Neurology Authors: Jamie M. Lawler, Jessica Hruschak, Kristin Aho, Yanni Liu, Ka I. Ip, Renee Lajiness ‐O’Neill, Katherine L. Rosenblum, Maria Muzik, Kate D. Fitzgerald Tags: ORIGINAL RESEARCH Source Type: research

Tract ‐specific analysis and neurocognitive functioning in sickle cell patients without history of overt stroke
ConclusionDecreased DTI ‐derived metrics were observed on six tracts in chronically anemic patients, regardless of anemia subtype, while two tracks with decreased measures were unique to SCD patients. Patients with WMHs had more significant FA abnormalities. Decreased FA values in the CC significantly correlated with all nine neurocognitive tests, suggesting a critical importance for CC in core neurocognitive processes. (Source: Brain and Behavior)
Source: Brain and Behavior - March 26, 2021 Category: Neurology Authors: Yaqiong Chai, Chaoran Ji, Julie Coloigner, Soyoung Choi, Melissa Balderrama, Chau Vu, Benita Tamrazi, Thomas Coates, John C. Wood, Sharon H. O'Neil, Natasha Lepore Tags: ORIGINAL RESEARCH Source Type: research

Hemodynamic and behavioral changes in older adults during cognitively demanding dual tasks
This study aims to examine how older adults mitigate executive demands while walking during cognit ively demanding tasks.MethodsTwenty healthy older adults (M  = 71.8  years,SD = 6.4) performed simple reaction time (SRT), go/no‐go (GNG), n‐back (NBK), and double number sequence (DNS) cognitive tasks of increasing difficulty while walking (i.e., dual task). Functional near infra‐red spectroscopy (fNIRS) was used to measure the hemodynamic response (i.e., oxy‐ [Hb O2] and deoxyhemoglobin [HbR]) changes in the prefrontal cortex (PFC) during dual and single tasks (i.e., walking alone). In addit...
Source: Brain and Behavior - March 26, 2021 Category: Neurology Authors: Talia Salzman, Diana Tob ón Vallejo, Nadia Polskaia, Lucas Michaud, Gabrielle St‐Amant, Yves Lajoie, Sarah Fraser Tags: ORIGINAL RESEARCH Source Type: research

Subjective versus objective symptom intensities ratings in cervical dystonia and hemifacial spasm across a botulinum neurotoxin cycle
ConclusionThe emotional situation should be assessed regularly in patients undergoing BoNT therapy. (Source: Brain and Behavior)
Source: Brain and Behavior - March 26, 2021 Category: Neurology Authors: Julia W öllner, David Weise, Bernd Leplow Tags: ORIGINAL RESEARCH Source Type: research

Olfactory impairment in Wilson ’s disease
ConclusionsPatients with WD may have stable, selective olfactory impairments. This selective pattern may be a useful tool for disease diagnosis and prediction. (Source: Brain and Behavior)
Source: Brain and Behavior - March 26, 2021 Category: Neurology Authors: Lei Chen, Xin Wang, Richard L. Doty, Shanshan Cao, Junxiu Yang, Feng Sun, Xiaoyan Yan Tags: ORIGINAL RESEARCH Source Type: research

The Association between Neprilysin gene polymorphisms and Alzheimer ’s disease in Tibetan population
ConclusionsNEP gene loci (rs701109, rs989692, rs9829757, rs3736187, rs1816558, rs6776185) were polymorphic in Tibetan population. No difference was found between these loci but for that male gender combined with allele C of NEP gene locus (rs701109) and T of gene locus (rs3736187) might be risk factors for AD in Tibet. (Source: Brain and Behavior)
Source: Brain and Behavior - March 26, 2021 Category: Neurology Authors: Siwei Chen, Dunzhu Mima, Haiqiang Jin, Qu Dan, Fei Wang, Juan Cai, Lin Shi, Huali Wang, Ailian Du, Ying Tang, Yongan Sun Tags: ORIGINAL RESEARCH Source Type: research

Employment and disability status in patients with functional (psychogenic nonepileptic) seizures
ConclusionThis study highlights that unemployment is a serious issue in patients with FS and psychiatric comorbidities play a significant role in the employment status in these patients. (Source: Brain and Behavior)
Source: Brain and Behavior - March 26, 2021 Category: Neurology Authors: Ali A. Asadi ‐Pooya, Mehdi Bazrafshan Tags: ORIGINAL RESEARCH Source Type: research

The role of cultural worldviews in predicating gambling risk perception and behavior in a Chinese sample
ConclusionThese findings demonstrated the important influence of cultural variables on perceived risk and behavior in gambling. Moreover, understanding gamblers ’ worldviews could be beneficial for problem gambling interventions. Future research directions and the limitations of the findings were discussed. (Source: Brain and Behavior)
Source: Brain and Behavior - March 26, 2021 Category: Neurology Authors: Wen Xue, Zhonglu Zeng, Zuyun Liu, Anthony D. G. Marks Tags: ORIGINAL RESEARCH Source Type: research

Altered spontaneous brain activity patterns in patients with neovascular glaucoma using amplitude of low ‐frequency fluctuations: A functional magnetic resonance imaging study
The patients with NVG exhibited anomalous spontaneous activity in different brain regions; these abnormal variations in specific brain regions can be considered possible clinical indices of NVG. AbstractBackgroundNeovascular glaucoma (NVG) can cause irreversible visual impairment and abnormal spontaneous changes in brain's visual system and other systems. There is little research on this aspect at present. However, amplitude of low ‐frequency fluctuations (ALFFs) can be used as an rs‐fMRI analysis technique for testing changes in spontaneous brain activity patterns.PurposeThe aim of this study was to probe the local ch...
Source: Brain and Behavior - March 26, 2021 Category: Neurology Authors: Zhi ‐You Peng, Yu‐Xin Liu, Biao Li, Qian‐Min Ge, Rong‐Bin Liang, Qiu‐Yu Li, Wen‐Qing Shi, Ya‐Jie Yu, Yi Shao Tags: ORIGINAL RESEARCH Source Type: research