Neuronal antibodies in adult patients with new ‐onset seizures: A prospective study
ConclusionsWe conclude that indiscriminate testing in patients presenting to a first seizure clinic with new ‐onset seizures or epilepsy is unlikely to improve detection of autoimmune epilepsy. (Source: Brain and Behavior)
Source: Brain and Behavior - October 6, 2019 Category: Neurology Authors: Johan Zelano, Markus Axelsson, Radu Constantinescu, Clas Malmestr öm, Eva Kumlien Tags: ORIGINAL RESEARCH Source Type: research

Cycle of violence in women victims of domestic violence: Qualitative analysis of OPD 2 interview
ConclusionThe research sought to collaborate with more evidence on the subject, suggesting a reformulation on forms of encounter to break the cycle of violence. (Source: Brain and Behavior)
Source: Brain and Behavior - October 6, 2019 Category: Neurology Authors: Luciane Maria Both, Ta ís Cristina Favaretto, Lúcia Helena Machado Freitas Tags: ORIGINAL RESEARCH Source Type: research

Reversible lesion in the splenium of the corpus callosum
ConclusionThe reversible lesions in the SCC found on MRI are not exclusive to encephalitis/encephalopathy but may be secondary to other disorders. (Source: Brain and Behavior)
Source: Brain and Behavior - October 6, 2019 Category: Neurology Authors: Syuichi Tetsuka Tags: REVIEW Source Type: research

Association between abdominal hernia and the risk of subsequent dementia
Hernia patients had a higher incidence rate and hazard ratio of dementia than those in non ‐hernia group. Advanced age, hypertension, head injury, and stroke were found to be risk factors for dementia. Patients with high socioeconomic status and history of coronary artery disease were unlikely to develop dementia in our cohort study. AbstractObjectiveMatrix metalloproteinases (MMPs) may play a role in the pathophysiology of neurodegenerative disease and hernia formation. This retrospective cohort study was designed to assess whether there is an association between hernia and the risk of dementia.Materials and MethodsPati...
Source: Brain and Behavior - October 6, 2019 Category: Neurology Authors: Kuo ‐Chuan Hung, Cheuk‐Kwan Sun, Jen‐Yin Chen, Hsiang‐Chi Wang, Chia‐Hung Kao Tags: ORIGINAL RESEARCH Source Type: research

Validation of the multiple sclerosis diagnosis in the Norwegian Patient Registry
ConclusionData from the NPR gave a good estimate of the occurrence of MS, but nearly one in 10 registered diagnoses was not correct. (Source: Brain and Behavior)
Source: Brain and Behavior - October 4, 2019 Category: Neurology Authors: Espen Benjaminsen, Kjell ‐Morten Myhr, Nina Grytten, Karl Bjørnar Alstadhaug Tags: ORIGINAL RESEARCH Source Type: research

Chronic nicotine exposure attenuates the effects of Δ9‐tetrahydrocannabinol on anxiety‐related behavior and social interaction in adult male and female rats
ConclusionsThe ability of nicotine prior exposure to produce long ‐lasting changes that alter the effects of acute THC administration suggests that chronic nicotine may induce neuroplastic changes that influence the subsequent response to novel THC exposure. (Source: Brain and Behavior)
Source: Brain and Behavior - October 3, 2019 Category: Neurology Authors: Laurie A. Manwell, Tanya Miladinovic, Elana Raaphorst, Shadna Rana, Sarah Malecki, Paul E. Mallet Tags: ORIGINAL RESEARCH Source Type: research

Hypothalamic hamartomas in adulthood: Clinical spectrum and treatment outcome —A unicenter experience
ConclusionsHypothalamic hamartoma ‐epilepsy syndrome clinical manifestations in adult patients are as variable as at pediatric age. Outcome of therapeutic options such as radiosurgery or VNS may be poorer at this stage. (Source: Brain and Behavior)
Source: Brain and Behavior - October 2, 2019 Category: Neurology Authors: Estefan ía Conde Blanco, Carla Anciones Martín, Isabel Manzanares, Francisco Gil López, Pedro Roldán, Antonio Donaire, Jordi Rumiá, Mar Carreño Tags: ORIGINAL RESEARCH Source Type: research

Postural stability in people with visual impairment
ConclusionThis study showed that subjects with visual impairment, regardless of eye opening or closure, behave in the same manner as sighted subjects with eyes closed. (Source: Brain and Behavior)
Source: Brain and Behavior - October 2, 2019 Category: Neurology Authors: Ahmad H. Alghadir, Abdullah Z. Alotaibi, Zaheen A. Iqbal Tags: ORIGINAL RESEARCH Source Type: research

Dentate gyrus neurons that are born at the peak of development, but not before or after, die in adulthood
DiscussionDelayed death of P6 ‐born neurons suggests these cells may play a unique role in hippocampal plasticity adulthood, for example, by contributing to the turnover of hippocampal memory. Their loss may also play a role in disorders that are characterized by hippocampal atrophy. (Source: Brain and Behavior)
Source: Brain and Behavior - October 1, 2019 Category: Neurology Authors: Tina Ciric, Shaina P. Cahill, Jason S. Snyder Tags: ORIGINAL RESEARCH Source Type: research

Central network changes in patients with advanced monocular blindness: A voxel ‐based morphometric study
ConclusionsWe found that patients with MB showed abnormal WMV and GMV, as evidenced by local changes in the brain. In addition, reduced GMV in specific parts of the brain was associated with the duration of blindness, which may indicate neuropathological mechanisms of visual loss in patients with MB. (Source: Brain and Behavior)
Source: Brain and Behavior - October 1, 2019 Category: Neurology Authors: Wen ‐Qing Shi, Yin He, Qing‐Hai Li, Li‐Ying Tang, Biao Li, Qi Lin, You‐Lan Min, Qing Yuan, Pei‐Wen Zhu, Rong‐Bing Liang, Yi Shao Tags: ORIGINAL RESEARCH Source Type: research

From clinical appearance to accurate management in acute ischemic stroke patients: With the guidance of innovative traditional Chinese medicine diagnosis
The four ‐type simplified classification of Integrated TCM and Western medicine in acute ischemic stroke has specific laboratory data to support. Simplified classification with TCM treatment and intervention of different patients improves the survival and treatment, which is an innovative, easy‐to‐ma ster clinical diagnosis and treatment model. AbstractObjectiveTo investigate the correlation between simplified classification and laboratory indicators in patients with acute ischemic stroke, also provide accurate evidences for simplified classification and guide clinical interventions and treatment.MethodsTwo...
Source: Brain and Behavior - September 30, 2019 Category: Neurology Authors: Juexian Song, Cuiyu Xu, Jing Zhang, Li Gao Tags: ORIGINAL RESEARCH Source Type: research

The effects of different fatigue levels on brain –behavior relationships in driving
ConclusionOur results help to explain the inconsistent findings among existing studies, which considered the effects of only acute fatigue on driving performance while ignoring different levels of resident fatigue, and potentially lead to practical and precise biomathematical models to better predict the performance of human operators. (Source: Brain and Behavior)
Source: Brain and Behavior - September 30, 2019 Category: Neurology Authors: Kuan ‐Chih Huang, Chun‐Hsiang Chuang, Yu‐kai Wang, Chi‐Yuan Hsieh, Jung‐Tai King, Chin‐Teng Lin Tags: ORIGINAL RESEARCH Source Type: research

Neutrophil –lymphocyte ratio predicts post‐thrombolysis early neurological deterioration in acute ischemic stroke patients
This study showed that elevated level of neutrophil –lymphocyte ratio (NLR) may predict post‐thrombolysis early neurological deterioration (END) in ischemic stroke patients. A cutoff value of 4.43 for NLR was detected in predicting post‐thrombolysis END with a sensitivity of 70.9% and a specificity of 79.3% (area under curve, 0.779; 95% CI, 0.7 31–0.822). Furthermore, our established nomogram indicated that higher NLR was an indicator of post‐thrombolysis END (c‐index was 0.789,p 
Source: Brain and Behavior - September 30, 2019 Category: Neurology Authors: Pengyu Gong, Yi Xie, Teng Jiang, Yukai Liu, Meng Wang, Huanhuan Sun, Shuting Zhang, Yingdong Zhang, Xiaohao Zhang, Junshan Zhou Tags: ORIGINAL RESEARCH Source Type: research

Clinical applications of transcranial magnetic stimulation in bipolar disorder
ConclusionsTranscranial magnetic stimulation is a promising approach for treating patients with BD who have failed to respond to pharmacological or psychosocial treatment. Future research should more clearly elucidate which TMS protocols may be most effective for a given bipolar patient. (Source: Brain and Behavior)
Source: Brain and Behavior - September 30, 2019 Category: Neurology Authors: Alexandra K. Gold, Ana Claudia Ornelas, Patricia Cirillo, Marco Antonio Caldieraro, Antonio Egidio Nardi, Andrew A. Nierenberg, Gustavo Kinrys Tags: REVIEW Source Type: research

Effects of irisin on the dysfunction of blood –brain barrier in rats after focal cerebral ischemia/reperfusion
Irisin exerts neuroprotective effects against blood –brain barrier (BBB) breakdown, but the underlying mechanisms remain unknown. In this work, we evaluated the neuroprotective effects of irisin against BBB breakdown in a rat model of focal cerebral ischemia/reperfusion (MCAO). And all our results indicated that the potential underlying mechanism o f neuroprotective effects of irisin might be associated with BBB permeability by regulating the expression and activity of matrix metalloproteinase‐9. AbstractObjectiveTo investigate whether irisin could protect against blood –brain barrier (BBB) dysfunction follow...
Source: Brain and Behavior - September 30, 2019 Category: Neurology Authors: Peipei Guo, Zhao Jin, Huisheng Wu, Xinyi Li, Jianjuan Ke, Zongze Zhang, Qiu Zhao Tags: ORIGINAL RESEARCH Source Type: research

Association between Lys198Asn polymorphism of endothelin ‐1 gene and ischemic stroke: A meta‐analysis
Endothelin (ET) ‐1 is a potent vasoconstrictor peptide produced by endothelial cells and associated with vascular dysfunction and cardiovascular disease. Lys198Asn is a single‐nucleotide polymorphism of gene encoding ET‐1 (EDN1). It is hypothesized that it might have a role in altering ET‐1 and ultimately l eading to vascular dysfunction and ischemic stroke. We therefore conducted a meta‐analysis to investigate the association between Lys198Asn polymorphism of EDN1 and susceptibility of ischemic stroke. The present meta‐analysis suggests that Lys198Asn polymorphism of EDN1 gene is associated with an i...
Source: Brain and Behavior - September 30, 2019 Category: Neurology Authors: Gaurav Nepal, Rajeev Ojha, Hari Prasad Dulal, Binod Kumar Yadav Tags: ORIGINAL RESEARCH Source Type: research

Cortical morphometry and structural connectivity relate to executive function and estradiol level in healthy adolescents
ConclusionsThe study provides evidence that the relationship between EF behavior and estradiol level related to bidirectional GM and WM differences, implying estradiol level has an influence on the putative structural regions underlying EF behavior. The findings represent a crucial link between EF behavior and hormonal influence on brain structure in adolescence. (Source: Brain and Behavior)
Source: Brain and Behavior - September 30, 2019 Category: Neurology Authors: Teodora Stoica, Lindsay Kathleen Knight, Farah Naaz, Melina Ramic, Brendan E. Depue Tags: ORIGINAL RESEARCH Source Type: research

The role of the brain –gut–microbiota axis in psychology: The importance of considering gut microbiota in the development, perpetuation, and treatment of psychological disorders
ConclusionMoving forward, integration of GM into the conceptualization and treatment of psychological illness will require the discipline of psychology to undergo a significant paradigm shift. While the importance of the GM in psychological well ‐being must be respected, it is not proposed to be a panacea, but instead, an additional arm to a multidisciplinary approach to treatment and prevention. (Source: Brain and Behavior)
Source: Brain and Behavior - September 30, 2019 Category: Neurology Authors: Michael Ganci, Emra Suleyman, Henry Butt, Michelle Ball Tags: REVIEW Source Type: research

Psychogenic nonepileptic seizures in pediatric population: A review
ConclusionPsychogenic nonepileptic seizures are common but frequently missed entity in pediatric population. Diagnosis could be difficult, especially in those children who have both epileptic and nonepileptic seizures; video EEG and home video can help clinicians in diagnosis. More studies are needed to better classify PNES in children and facilitate diagnosis and treatment. (Source: Brain and Behavior)
Source: Brain and Behavior - September 30, 2019 Category: Neurology Authors: Francesca Felicia Operto, Giangennaro Coppola, Roberta Mazza, Grazia Maria Giovanna Pastorino, Stella Campanozzi, Lucia Margari, Michele Roccella, Rosa Marotta, Marco Carotenuto Tags: REVIEW Source Type: research

Episodic memory improvements due to noninvasive stimulation targeting the cortical –hippocampal network: A replication and extension experiment
ConclusionThese findings confirm the beneficial effects of stimulation on episodic memory that were reported previously and indicate that stimulation ‐related gains in new learning ability do not come at the price of accelerated long‐term forgetting. (Source: Brain and Behavior)
Source: Brain and Behavior - September 30, 2019 Category: Neurology Authors: Molly S. Hermiller, Erica Karp, Aneesha S. Nilakantan, Joel L. Voss Tags: ORIGINAL RESEARCH Source Type: research

Neuroanatomy and function of human sexual behavior: A neglected or unknown issue?
ConclusionsProviding healthcare professionals with information concerning sexual behavior may overcome useless and sometimes dangerous barriers and improve patient management, since sexual well ‐being is considered one of the most important aspects of one's quality of life. (Source: Brain and Behavior)
Source: Brain and Behavior - September 30, 2019 Category: Neurology Authors: Rocco S. Calabr ò, Alberto Cacciola, Daniele Bruschetta, Demetrio Milardi, Fabrizio Quattrini, Francesca Sciarrone, Gianluca Rosa, Placido Bramanti, Giuseppe Anastasi Tags: REVIEW Source Type: research

Resting ‐state functional magnetic resonance imaging versus task‐based activity for language mapping and correlation with perioperative cortical mapping
ConclusionResting ‐state fMRI for presurgical language mapping is easy to implement, allowing the identification of functional brain language network with a greater sensitivity than task‐based fMRI, at the cost of some precautions and a lower specificity. Further study is required to compare both the sensitivity and the specificity of the two methods and to evaluate the clinical value of rsfMRI as an alternative tool for the presurgical identification of brain language areas. (Source: Brain and Behavior)
Source: Brain and Behavior - September 30, 2019 Category: Neurology Authors: Jean ‐Michel Lemée, David Hassanein Berro, Florian Bernard, Eva Chinier, Louis‐Marie Leiber, Philippe Menei, Aram Ter Minassian Tags: ORIGINAL RESEARCH Source Type: research

Aberrant patterns of default ‐mode network functional connectivity associated with metabolic syndrome: A resting‐state study
ConclusionsOur results suggest that MetS is associated with alterations in FC between the DMN and other regions of the brain. Furthermore, these results indicate that the overall burden of vascular RFs associated with MetS may, in part, contribute to the pathophysiology underlying aberrant FC in the DMN. (Source: Brain and Behavior)
Source: Brain and Behavior - September 30, 2019 Category: Neurology Authors: Barnaly Rashid, Sheena I. Dev, Michael Esterman, Nicolette F. Schwarz, Tori Ferland, Francesca C. Fortenbaugh, William P. Milberg, Regina E. McGlinchey, David H. Salat, Elizabeth C. Leritz Tags: ORIGINAL RESEARCH Source Type: research

Interdependence between dorsal and ventral hippocampus during spatial navigation
ConclusionsTaken together, results indicate that for spatial processing, the hippocampus functions as a single integrated structure along the longitudinal axis. (Source: Brain and Behavior)
Source: Brain and Behavior - September 30, 2019 Category: Neurology Authors: Shang Lin (Tommy) Lee, Dana Lew, Victoria Wickenheisser, Etan J. Markus Tags: ORIGINAL RESEARCH Source Type: research

Monocyte/lymphocyte ratio is associated with carotid stenosis in ischemic stroke: A retrospective analysis
ConclusionMonocyte/lymphocyte ratio plays important roles in carotid stenosis in patients with ischemic stroke and is an independent risk factor of the severity of carotid stenosis. Therefore, MLR might be considered a potential index in the diagnosis of carotid stenosis in patients with ischemic stroke. (Source: Brain and Behavior)
Source: Brain and Behavior - September 30, 2019 Category: Neurology Authors: Bo Zuo, Sha Zhu, Xue Meng, Danhua Zhao, Jun Zhang Tags: ORIGINAL RESEARCH Source Type: research

Calcium imaging of primary canine sensory neurons: Small ‐diameter neurons responsive to pruritogens and algogens
ConclusionRatiometric calcium imaging demonstrated that small ‐diameter canine sensory neurons can be activated by multiple stimuli, and a single neuron can react to both a pruritogenic stimulation and an algogenic stimulation. (Source: Brain and Behavior)
Source: Brain and Behavior - September 30, 2019 Category: Neurology Authors: Joy Rachel C. Ganchingco, Tomoki Fukuyama, Jeffrey A. Yoder, Wolfgang B äumer Tags: ORIGINAL RESEARCH Source Type: research

Brain activity during traditional textbook and audiovisual ‐3D learning
ConclusionsOverall, the results indicate that a similar level of knowledge may be achieved via different cognitive strategies. In our experiment, audiovisual learning appeared to benefit from prefrontal executive resources (as opposed to memorizing verbal information) more than traditional textbook learning. (Source: Brain and Behavior)
Source: Brain and Behavior - September 30, 2019 Category: Neurology Authors: Jesus Pujol, Laura Blanco ‐Hinojo, Gerard Martínez‐Vilavella, Lucila Canu‐Martín, Anna Pujol, Víctor Pérez‐Sola, Joan Deus Tags: ORIGINAL RESEARCH Source Type: research

The relative contributions of visual and semantic information in the neural representation of object categories
ConclusionsOur findings suggest that perceptual features help organize mental categories throughout the object processing hierarchy. Most notably, visual similarity also influenced adaptation in nonvisual brain regions (i.e., AnG and DMPFC). We conclude that category ‐relevant visual features are maintained in higher‐order conceptual representations and visual information plays an important role in both the acquisition and neural representation of conceptual object categories. (Source: Brain and Behavior)
Source: Brain and Behavior - September 27, 2019 Category: Neurology Authors: Lindsay W. Victoria, John A. Pyles, Michael J. Tarr Tags: ORIGINAL RESEARCH Source Type: research

Striatal responsiveness to reward under threat ‐of‐shock and working memory load: A preliminary study
ConclusionsThese findings provide initial evidence that both stress and cognitive load modulate striatal responsiveness during feedback delivery but not during anticipation in healthy adults. Of clinical importance, sustained stress exposure might go along with dysregulated arousal, increasing therefore the risk for the development of maladaptive incentive ‐triggered motivation. This study brings new insight that might help to build a framework to understand common stress‐related disorders, given that these psychiatric disorders involve disturbances of the reward system, cognitive deficits, and abnormal stress reactivi...
Source: Brain and Behavior - September 26, 2019 Category: Neurology Authors: Claudie Gaillard, Matthias Guillod, Monique Ernst, Salvatore Torrisi, Andrea Federspiel, Dominik Schoebi, Romina E. Recabarren, Xinyi Ouyang, Christoph Mueller ‐Pfeiffer, Antje Horsch, Philipp Homan, Roland Wiest, Gregor Hasler, Chantal Mar Tags: ORIGINAL RESEARCH Source Type: research

Prognostic value of white matter lesion shrinking in early multiple sclerosis: An intuitive or na ïve notion?
ConclusionWe found no indication of a prognostic value of WML shrinking in early MS patients. WML shrinking seems to be related to waning of acute inflammation. (Source: Brain and Behavior)
Source: Brain and Behavior - September 26, 2019 Category: Neurology Authors: Viola Pongratz, Paul Schmidt, Matthias Bussas, Sophia Grahl, Christian Gaser, Achim Berthele, Muna ‐Miriam Hoshi, Jan Kirschke, Claus Zimmer, Bernhard Hemmer, Mark Mühlau Tags: ORIGINAL RESEARCH Source Type: research

Electrophysiological correlates of masked repetition and conceptual priming for visual objects
ConclusionsThese results indicated that masked repetition and conceptual priming were associated with spatiotemporally different ERP effects and that the N400 of visual objects was sensitive to automatic semantic spreading. (Source: Brain and Behavior)
Source: Brain and Behavior - September 26, 2019 Category: Neurology Authors: Bingbing Li, Chuanji Gao, Juan Wang Tags: ORIGINAL RESEARCH Source Type: research

A novel ABCD1 gene mutation causes adrenomyeloneuropathy in a Chinese family
ConclusionA novel missense mutation in theABCD1 gene was identified in a Chinese family, which caused an unusual manifestation of adult ‐onset AMN. This discovery is beneficial for the genetic counseling of patients with X‐linked adrenoleukodystrophy. (Source: Brain and Behavior)
Source: Brain and Behavior - September 26, 2019 Category: Neurology Authors: Chao Wang, Hongchao Liu, Bing Han, Hui Zhu, Jingyao Liu Tags: ORIGINAL RESEARCH Source Type: research

Predictive value of the THRIVE score for outcome in patients with acute basilar artery occlusion treated with thrombectomy
ConclusionsA high THRIVE score was independently associated with an increased risk of poor functional outcome and all ‐cause mortality in AIS patients with BAO who underwent thrombectomy treatment. Moreover, the THRIVE score appeared to be a better predictor of clinical outcome than the NIHSS score. (Source: Brain and Behavior)
Source: Brain and Behavior - September 26, 2019 Category: Neurology Authors: Beilei Chen, Liu Yang, Jing Hang, Shoujiang You, Jun Li, Xiaobo Li, Liangzhu Wang, Li Jiang, Wei Li, Hailong Yu Tags: ORIGINAL RESEARCH Source Type: research

The efficacy and safety of botulinum toxin type A in treatment of trigeminal neuralgia and peripheral neuropathic pain: A meta ‐analysis of randomized controlled trials
ConclusionPooled data from our meta ‐analysis suggest that BTX‐A is efficacious and safe in treating TN and PNP. However, due to the limited sample size and heterogeneity, further larger and well‐designed RCTs are imperative to validate these findings. (Source: Brain and Behavior)
Source: Brain and Behavior - September 21, 2019 Category: Neurology Authors: Jiangshan Wei, Xiangyu Zhu, Guang Yang, Jun Shen, Peng Xie, Xiaohua Zuo, Lei Xia, Qiu Han, Ying Zhao Tags: ORIGINAL RESEARCH Source Type: research

Parcellation ‐based tractographic modeling of the dorsal attention network
ConclusionsWe present a tractographic model of the DAN. This model comprises parcellations within the frontal, parietal, and occipital cortices principally linked through the superior longitudinal fasciculus. Future studies may refine this model with the ultimate goal of clinical application. (Source: Brain and Behavior)
Source: Brain and Behavior - September 19, 2019 Category: Neurology Authors: Parker G. Allan, Robert G. Briggs, Andrew K. Conner, Christen M. O'Neal, Phillip A. Bonney, Brian D. Maxwell, Cordell M. Baker, Joshua D. Burks, Goksel Sali, Chad A. Glenn, Michael E. Sughrue Tags: ORIGINAL RESEARCH Source Type: research

Issue Information
Cover image © aodaodaodaod / Shutterstock (Source: Brain and Behavior)
Source: Brain and Behavior - September 18, 2019 Category: Neurology Tags: ISSUE INFORMATION Source Type: research

Reperfusion therapy for minor stroke: A systematic review and meta ‐analysis
ConclusionsAlthough thrombolysis might increase the risk of ICH based on existing studies, patients with acute minor ischemic stroke could still benefit from thrombolysis at 3  months from the onset. (Source: Brain and Behavior)
Source: Brain and Behavior - September 18, 2019 Category: Neurology Authors: Lihuan Lan, Xiaoming Rong, Xiangpen Li, Xiaoni Zhang, Jingrui Pan, Hongxuan Wang, Qingyu Shen, Ying Peng Tags: ORIGINAL RESEARCH Source Type: research

Heterogeneous nonataxic phenotypes of spinocerebellar ataxia in a Taiwanese population
ConclusionsParkinsonism, dystonia, and cognitive ‐psychiatric symptoms are common features in patients with SCA mutations in our population. Our study identifies a different clinical spectrum of SCA1, SCA2, SCA3, SCA6, and SCA17 compared to Caucasians. (Source: Brain and Behavior)
Source: Brain and Behavior - September 16, 2019 Category: Neurology Authors: Szu ‐Ju Chen, Ni‐Chung Lee, Yin‐Hsiu Chien, Wuh‐Liang Hwu, Chin‐Hsien Lin Tags: ORIGINAL RESEARCH Source Type: research

Children's physiological reactivity in emotion contexts and prosocial behavior
ConclusionsThese findings provide preliminary support for a nonlinear association between children's parasympathetic emotion reactivity and later prosocial behavior, and suggest that children's ANS regulation in sad emotion contexts may be particularly important for understanding prosocial development. (Source: Brain and Behavior)
Source: Brain and Behavior - September 15, 2019 Category: Neurology Authors: Brianne R. Coulombe, Kristen L. Rudd, Tuppett M. Yates Tags: ORIGINAL RESEARCH Source Type: research

Sociality deficits in serine racemase knockout mice
ConclusionsSerine racemase knockout mice demonstrate abnormalities in socio ‐communicative behaviors consistent with an impairment in sociality, a negative symptom of schizophrenia. (Source: Brain and Behavior)
Source: Brain and Behavior - September 12, 2019 Category: Neurology Authors: Tatyana M. Matveeva, Marc T. Pisansky, Amy Young, Robert F. Miller, Jonathan C. Gewirtz Tags: ORIGINAL RESEARCH Source Type: research

Cardiovascular surgery experience does not significantly improve patients' response to stroke
ConclusionsCardiovascular surgical history does not influence patients' likelihood of calling EMS more often at stroke onset. Patients receiving cardiovascular surgeries should be counseled regarding stroke recognition, proper response to stroke, and the importance of controlling risk factors. (Source: Brain and Behavior)
Source: Brain and Behavior - September 12, 2019 Category: Neurology Authors: Shengde Li, Li ‐Ying Cui, Craig Anderson, Chunpeng Gao, Chengdong Yu, Guangliang Shan, Longde Wang, Bin Peng, on behalf of the FAST‐RIGHT Investigators and Coordinators, Nan Jiang, Yuehui Hong, Weidong Liu, Jian Li, Suiqiang Zhu, Ping X Tags: ORIGINAL RESEARCH Source Type: research

Functional connectivity between white matter and gray matter based on fMRI for Alzheimer's disease classification
ConclusionThese results indicated that there is a wide range of disconnection between WM and GM in AD, and association between WM and GM based on fMRI only is an effective strategy, and the FC between WM and GM could be a potential biomarker in the process of cognitive impairment and AD. (Source: Brain and Behavior)
Source: Brain and Behavior - September 11, 2019 Category: Neurology Authors: Jie Zhao, Xuetong Ding, Yuhang Du, Xuehu Wang, Guozun Men Tags: ORIGINAL RESEARCH Source Type: research

A pilot study on high amplitude low frequency –music impulse stimulation as an add‐on treatment for depression
ConclusionsHigh Amplitude Low Frequency –Music Impulse Stimulation treatment seems to give beneficial effect as an add‐on treatment for depression. HALF‐MIS appears to be a safe and effective add‐on treatment for depression. (Source: Brain and Behavior)
Source: Brain and Behavior - September 11, 2019 Category: Neurology Authors: Gudrun Agusta Sigurdard óttir, Peter Michael Nielsen, Jesper Rønager, August Gabriel Wang Tags: ORIGINAL RESEARCH Source Type: research

Clinical correlates of mathematical modeling of cortical spreading depression: Single ‐cases study
DiscussionThis case ‐control study suggests that the cortical geometry may contribute to the modality of CSD evolution and partly to clinical expression of aura symptoms. The simulated CSD is a large and diffuse phenomenon, possibly capable to activate trigeminal nociceptors and to involve cortical areas devoted to p ain processing. (Source: Brain and Behavior)
Source: Brain and Behavior - September 10, 2019 Category: Neurology Authors: Julia M. Kroos, Marina Tommaso, Sebastiano Stramaglia, Eleonora Vecchio, Nicola Burdi, Luca Gerardo ‐Giorda Tags: ORIGINAL RESEARCH Source Type: research

Test –retest reproducibility of a multi‐atlas automated segmentation tool on multimodality brain MRI
ConclusionIn general, the reproducibility of the different modalities was slightly superior to that of widely used software. This analysis serves as a normative reference for planning samples and for the interpretation of structure ‐based MRI studies. (Source: Brain and Behavior)
Source: Brain and Behavior - September 4, 2019 Category: Neurology Authors: Thiago J. R. Rezende, Brunno M. Campos, Johnny Hsu, Yue Li, Can Ceritoglu, Kwame Kutten, Marcondes C. Fran ça Junior, Susumu Mori, Michael I. Miller, Andreia V. Faria Tags: ORIGINAL RESEARCH Source Type: research

Miconazole alleviates peripheral nerve crush injury by mediating a macrophage phenotype change through the NF ‐κB pathway
ConclusionsOur data suggest that miconazole can effectively alleviate PNI, and the mechanism involves mediating a phenotype change of M1/ M2 macrophages. Thus, miconazole may represent a potential therapeutic intervention for nerve crush injury. (Source: Brain and Behavior)
Source: Brain and Behavior - September 4, 2019 Category: Neurology Authors: Liangliang Zhang, Xiuju Chen, Zengyun Liu, Qingluan Han, Liguo Tang, Zhen Tian, Zhiyong Ren, Cunmin Rong, Hui Xu Tags: ORIGINAL RESEARCH Source Type: research

High levels of plasma fibrinogen are related to post ‐stroke cognitive impairment
This study is carried out in the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province, China. A total of 210 patients with acute ischemic stroke were enrolled in this study. Ultimately, 134 patients completed 3 ‐month follow‐up. Blood samples were collected at hospital admission. Cognitive function was evaluated 3 months after stroke. All patients underwent the Mini‐Mental State Examination (MMSE) after 3 months.ResultsHigher levels of fibrinogen were observed in patients with post ‐stroke cognitive impairment compared with the non‐PSCI group (p 
Source: Brain and Behavior - September 2, 2019 Category: Neurology Authors: Yuntao Liu, Huijun Chen, Kai Zhao, Weilei He, Shasha Lin, Jincai He Tags: ORIGINAL RESEARCH Source Type: research

Impaired empathy but no theory of mind deficits in adult attention deficit hyperactivity disorder
This study explored the extent to which social interaction problems of treatment ‐naïve adults with ADHD can be attributed to deficits in theory of mind using established neuropsychological tests. The results revealed that adults with ADHD showed impairment in various executive functions and the ability to empathize but no theory of mind deficits. Our findings imply that ToM impairments, even when present in adult ADHD, appear to be independent of executive deficits and might be explained by comorbid disorders. AbstractObjectiveThe cognitive capacity to change perspective is referred to as theory of mind (ToM). ToM ...
Source: Brain and Behavior - September 2, 2019 Category: Neurology Authors: Mona Abdel ‐Hamid, Franziska Niklewski, Philipp Heßmann, Nika Guberina, Melanie Kownatka, Markus Kraemer, Norbert Scherbaum, Isabel Dziobek, Claudia Bartels, Jens Wiltfang, Bernhard Kis Tags: ORIGINAL RESEARCH Source Type: research

Childhood ‐onset cerebellar ataxia in Japan: A questionnaire‐based survey
ConclusionsThe diagnostic rate of childhood ‐onset CA in the current study was comparable to those reported in other countries. The high prevalence of autosomal dominant ataxia, especially DRPLA, was a signature of CA in Japan. These data offer insights into the characteristics of childhood‐onset CA in the Japanese population. (Source: Brain and Behavior)
Source: Brain and Behavior - August 30, 2019 Category: Neurology Authors: Hiroya Ono, Yuko Shimizu ‐Motohashi, Kazushi Maruo, Eri Takeshita, Akihiko Ishiyama, Takashi Saito, Hirofumi Komaki, Eiji Nakagawa, Masayuki Sasaki Tags: ORIGINAL RESEARCH Source Type: research

Association between giant cell glioblastoma and glioblastoma multiforme in the United States: A retrospective cohort study
This study is a historical cohort type of study and is conducted on adults and elderly individuals with GBM or GCG from the years 1985 –2014 in the U.S. Data were collected from the Surveillance, Epidemiology, and End Results Program (SEER) database. The study exposure was GBM or GCG and the outcome was mortality. The potential confounders were age, sex, race, ethnicity, year of diagnosis, primary site, brain overlap, and surgery . A chi‐square test was used for categorical data. A univariate analysis was used for variables having ap‐value
Source: Brain and Behavior - August 29, 2019 Category: Neurology Authors: Amro K. Bin Abdulrahman, Khalid A. Bin Abdulrahman, Yousef R. Bukhari, Abdulaziz M. Faqihi, Juan Gabriel Ruiz Tags: ORIGINAL RESEARCH Source Type: research