Cerebrospinal fluid light and heavy neurofilament level increased in anti ‐N‐methyl‐d‐aspartate receptor encephalitis
ConclusionsBriefly, CSF Nf ‐L levels notably increased in anti‐NMDAR encephalitis patients in acute phase and positively correlated with disease severity. It could be considered as a useful indicator for clinical outcomes and prognosis. (Source: Brain and Behavior)
Source: Brain and Behavior - July 17, 2019 Category: Neurology Authors: Jiayu Li, Yong Gu, Hongwei An, Zheyi Zhou, Dong Zheng, Zhanhang Wang, Zehuai Wen, Hai ‐Ying Shen, Qi Wang, Honghao Wang Tags: ORIGINAL RESEARCH Source Type: research

Magnetic resonance imaging findings and clinical manifestations in cerebral angiostrongyliasis from Dali, China
ConclusionThe possibility ofA.  cantonensis infection should be considered in the effective use of albendazole or mebendazole as a treatment. Combining clinical history with laboratory examination is helpful in diagnosingA.  cantonensis infection. A final definite diagnosis can be confirmed by detecting larvae in the CSF. The administration of corticosteroids during pathogen therapy can substantially reduce the therapeutic response. (Source: Brain and Behavior)
Source: Brain and Behavior - July 17, 2019 Category: Neurology Authors: Bin Yang, Ling Yang, Yili Chen, Guangming Lu Tags: ORIGINAL RESEARCH Source Type: research

Psychological and physiological effects of viewing a money plant by older adults
ConclusionsOur findings indicate that viewing a money plant for 5  min may enhance both psychological and physiological relaxation in older adults. (Source: Brain and Behavior)
Source: Brain and Behavior - July 15, 2019 Category: Neurology Authors: Ahmad Hassan, Chen Qibing, Liu Yinggao, Jiang Tao, Guo Li, Mingyan Jiang, Li Nian, Lv Bing ‐Yang Tags: ORIGINAL RESEARCH Source Type: research

Issue Information
Brain and Behavior, Volume 9, Issue 7, July 2019. (Source: Brain and Behavior)
Source: Brain and Behavior - July 12, 2019 Category: Neurology Tags: ISSUE INFORMATION Source Type: research

Differences between physicians' and nurse practitioners' viewpoints on reasons for clozapine underprescription
ConclusionsWe conclude that slight differences exist between physicians' and nurse practitioners' viewpoints on patient ‐related and prescriber‐related reasons for CLZ underprescription. Future research projects should involve patients to elucidate whether the patient‐related factors put forward by prescribers align with the patients' opinions. (Source: Brain and Behavior)
Source: Brain and Behavior - July 12, 2019 Category: Neurology Authors: Cynthia Okhuijsen ‐Pfeifer, Dan Cohen, Jan P. A. M. Bogers, Cato M. H. Vos, Elianne A. H. Huijsman, René S. Kahn, Jurjen J. Luykx Tags: ORIGINAL RESEARCH Source Type: research

Combining Prospective Acquisition CorrEction (PACE) with retrospective correction to reduce motion artifacts in resting state fMRI data
ConclusionsPACE when used in conjunction with retrospective motion correction methods including nuisance signal and motion parameter regression, and censoring, did prove effective in almost eliminating head motion artifacts, even with a lower censoring threshold. Use of a lower censoring threshold could provide substantial savings in data that would otherwise be lost to censoring. Three ‐dimensional PACE has negligible overhead in terms of scan time, sequence modifications or additional and hence presents an attractive option for head motion correction in high‐throughput resting‐state BOLD imaging. (Source: Brain and Behavior)
Source: Brain and Behavior - July 11, 2019 Category: Neurology Authors: Pradyumna Lanka, Gopikrishna Deshpande Tags: ORIGINAL RESEARCH Source Type: research

Comparing model ‐based cerebrovascular physiomarkers with DTI biomarkers in MCI patients
We compare the novel model ‐based hemodynamic physiomarker of Dynamic Vasomotor Reactivity (DVR) with biomarkers based on Diffusion Tensor Imaging (DTI) in terms of their ability to delineate patients with amnestic Mild Cognitive Impairment (MCI) from age‐matched cognitively normal controls. It was found that statisticall y significant delineation between MCI patients and controls was comparable for DVR or DTI markers (p 
Source: Brain and Behavior - July 9, 2019 Category: Neurology Authors: Vasilis Z. Marmarelis, Dae C. Shin, Takashi Tarumi, Rong Zhang Tags: ORIGINAL RESEARCH Source Type: research

Symptom relief during last week of life in neurological diseases
ConclusionsThe study reveals high symptom burden and differences in palliative care between the groups during the last week of life. There is a need for person ‐centered care planning based on a palliative approach, focused on improving symptom assessments, relief, and end‐of‐life conversations. (Source: Brain and Behavior)
Source: Brain and Behavior - July 9, 2019 Category: Neurology Authors: Anneli Ozanne, Richard Sawatzky, Cecilia H åkanson, Anette Alvariza, Carl Johan Fürst, Kristofer Årestedt, Joakim Öhlén Tags: ORIGINAL RESEARCH Source Type: research

An information network flow approach for measuring functional connectivity and predicting behavior
ConclusionsInformation flow may be a useful complement to Pearson's correlation as a measure of FC because of its advantages for nonlinear analysis and network structure characterization. (Source: Brain and Behavior)
Source: Brain and Behavior - July 9, 2019 Category: Neurology Authors: Sreejan Kumar, Kwangsun Yoo, Monica D. Rosenberg, Dustin Scheinost, R. Todd Constable, Sheng Zhang, Chiang ‐Shan R. Li, Marvin M. Chun Tags: ORIGINAL RESEARCH Source Type: research

The role of chaperone ‐mediated autophagy in neurotoxicity induced by alpha‐synuclein after methamphetamine exposure
ConclusionsThe results provide in vivo evidence for CMA plays a pivotal role in METH ‐induced neurotoxicity, and upregulation of Hsc70 expression significantly protects neuronal cells against METH‐induced toxicity. This research may pave the way for potential therapeutic approaches targeting CMA for METH abuse and neurodegenerative disorders. (Source: Brain and Behavior)
Source: Brain and Behavior - July 9, 2019 Category: Neurology Authors: Leping Sun, Yongling Lian, Jiuyang Ding, Yunle Meng, Chen Li, Ling Chen, Pingming Qiu Tags: ORIGINAL RESEARCH Source Type: research

Microstructural abnormalities in callosal fibers and their relationship with cognitive function in schizophrenia: A tract ‐specific analysis study
ConclusionOur results suggest that microstructural abnormalities in the callosal white matter fibers connecting bilateral temporal lobe cortices contribute to poor executive function and severe negative symptom in patients with schizophrenia. (Source: Brain and Behavior)
Source: Brain and Behavior - July 8, 2019 Category: Neurology Authors: Yuji Ohoshi, Shun Takahashi, Shinichi Yamada, Takuya Ishida, Kumi Tsuda, Tomikimi Tsuji, Masaki Terada, Kazuhiro Shinosaki, Satoshi Ukai Tags: ORIGINAL RESEARCH Source Type: research

Structural neuroimaging differentiates vulnerability from disease manifestation in colombian families with Huntington ’s disease
ConclusionStriatal GM volume, global brain atrophy and PVS burden may serve as differential indicators of disease manifestation in HD. The Raven's Standard Progressive Matrices could be a cognitive test worth to consider in the differentiation of vulnerability versus overt disease in HD. (Source: Brain and Behavior)
Source: Brain and Behavior - July 5, 2019 Category: Neurology Authors: Maria C. Vald és Hernández, Janna Abu‐Hussain, Xinyi Qiu, Josef Priller, Mario Parra Rodríguez, Mariana Pino, Sandra Báez, Agustín Ibáñez Tags: ORIGINAL RESEARCH Source Type: research

Sensory deafferentation modulates and redistributes neurocan in the rat auditory brainstem
ConclusionsThe ECM variously participates in adaptive responses to sudden deafness bySD on several levels along the central auditory pathway, with a striking spatial and temporal relationship of Ncan modulation to astrocytic activation and to synaptogenesis. (Source: Brain and Behavior)
Source: Brain and Behavior - July 4, 2019 Category: Neurology Authors: Josef Heusinger, Heika Hildebrandt, Robert ‐Benjamin Illing Tags: ORIGINAL RESEARCH Source Type: research

Long ‐term consequences of early postnatal lead exposure on hippocampal synaptic activity in adult mice
ConclusionsOverall, we show for the first time that early exposure to either high or lowest level Pb has long ‐term consequences on different synaptic properties of at least two hippocampal synapses. Such consequences of early Pb exposure might worsen the cognitive decline observed in aging men and women. Our results suggest that additional efforts should focus on the consequences of early Pb exposure esp ecially in at‐risk communities. (Source: Brain and Behavior)
Source: Brain and Behavior - July 3, 2019 Category: Neurology Authors: Anahis Tena, Eduardo Peru, Luis E. Martinetti, Jose C. Cano, Carla D. Loyola Baltazar, Amy E. Wagler, Rachid Skouta, Karine Fenelon Tags: ORIGINAL RESEARCH Source Type: research

Brain activity associated with Dual ‐task performance of Ankle motor control during cognitive challenge
The purpose of this study was to use fMRI to understand which regions are involved in resolving Dual ‐task interference associated with high levels of Ankle motor control during the Flanker cognitive task—activity in 3 brain regions (Brodmann area (BA) 5, BA6, and the left caudate) correlated with performance on the Flanker task during the Dual‐task condition (r = 0.511,p = 0.04;r = −0.508,p = 0.04;r = 0.550,p = 0.03, respectively)—Ankle motor control is prioritized over a cognitive task during Dual‐task performance which suggests a trade...
Source: Brain and Behavior - July 2, 2019 Category: Neurology Authors: Sue Peters, Janice Eng, Teresa Liu ‐Ambrose, Michael R. Borich, Elizabeth Dao, Ameen Amanian, Lara A. Boyd Tags: ORIGINAL RESEARCH Source Type: research

The impact of maternal touch of the abdomen on cardiotocography fetal patterns
ConclusionFetal movements increases during maternal touch of the abdomen. (Source: Brain and Behavior)
Source: Brain and Behavior - June 29, 2019 Category: Neurology Authors: Alex S. Rolland Souza, Emanuela V. V. Cavalcante, Candice A. Macedo, St ênio G. Freitas, Amanda T. P. Figueiredo, Susi A. Alves, Thaíse C. A. C. Silva, Gustavo F. Albuquerque Souza, João G. Alves Tags: ORIGINAL RESEARCH Source Type: research

Olfactory discrimination in disorders of consciousness: A new sniff protocol
ConclusionsDespite the limits of this preliminary research, the ODP can be useful for clinicians for the preliminary assessment of the olfactory discrimination in patients with DOC. (Source: Brain and Behavior)
Source: Brain and Behavior - June 28, 2019 Category: Neurology Authors: Davide Sattin, Maria Grazia Bruzzone, Stefania Ferraro, Anna Nigri, Matilde Leonardi, Davide Guido, On behalf of Coma Research Center, Fondazione IRCCS Istituto Neurologico “Carlo Besta”, Milan, Italy Tags: ORIGINAL RESEARCH Source Type: research

Individuals in the prediabetes stage exhibit reduced hippocampal tail volume and executive dysfunction
ConclusionsOur results support that the left hippocampal tail volume may be served as an early marker of diabetes ‐related brain damage, associated with executive dysfunction. Clinicians should pay closer attention to adults in the prediabetes stage to prevent later cognitive impairment. (Source: Brain and Behavior)
Source: Brain and Behavior - June 25, 2019 Category: Neurology Authors: Sun Dong, Lu Dongwei, Junjian Zhang, Jinyu Liang, Zhenmeng Sun, Jian Fang Tags: ORIGINAL RESEARCH Source Type: research

Lack of association between serum homocysteine level and middle cerebral artery stenosis
ConclusionsThe study indicates a lack of association between serum HCY level and MCA stenosis, which may partially explain the negative results of secondary prevention clinical trials focused on lowering serum HCY level. Future studies on HCY reduction should focus more on primary prevention of ischemic stroke. (Source: Brain and Behavior)
Source: Brain and Behavior - June 21, 2019 Category: Neurology Authors: Haitao Zhou, Chao Huang, Ruihua Liu, Chao Liu, Congmin Ma, Xiangyang Ren Tags: ORIGINAL RESEARCH Source Type: research

Neuroprotective effect of omega ‐3 fatty acids on spinal cord injury induced rats
ConclusionTaken together, our results suggested that omega ‐3 fatty acid supplementation reduced oxidative stress, apoptosis, and the levels of inflammatory markers in ischemia‐reperfusion‐induced rats. (Source: Brain and Behavior)
Source: Brain and Behavior - June 21, 2019 Category: Neurology Authors: Jiaqi Bi, Chong Chen, Peiyu Sun, Haining Tan, Fan Feng, Jianxiong Shen Tags: ORIGINAL RESEARCH Source Type: research

Cistanche extracts ameliorates the neurotoxicity induced by hydrogen peroxide in new mutant DJ ‐1‐transfected neuroblastoma cellular models
ConclusionsThese findings suggest that we successfully established sensitive and stable H2O2 induced L166P DJ ‐1‐ and C106S DJ‐1‐transfected SH‐SY5Y cell models of PD andCistanche extracts may thus be useful for treating PD. (Source: Brain and Behavior)
Source: Brain and Behavior - June 19, 2019 Category: Neurology Authors: Chunna An, Xiaoping Pu, Qi Wang, Hongning Zhang Tags: ORIGINAL RESEARCH Source Type: research

Cover Image, Volume 9, Issue 6
The cover image is based on the Original ArticleIndividual differences in level of wisdom are associated with brain activation during a moral decision ‐making task by Michael L. Thomas et al., DOI:10.1002/brb3.1302. (Source: Brain and Behavior)
Source: Brain and Behavior - June 17, 2019 Category: Neurology Authors: Michael L. Thomas, Averria S. Martin, Lisa Eyler, Ellen E. Lee, Eduardo Macagno, Mary Devereaux, Winston Chiong, Dilip V. Jeste Tags: COVER IMAGE Source Type: research

Issue Information
Brain and Behavior, Volume 9, Issue 6, June 2019. (Source: Brain and Behavior)
Source: Brain and Behavior - June 17, 2019 Category: Neurology Tags: ISSUE INFORMATION Source Type: research

Anxiety and depression in patients with suspected carpal tunnel syndrome – A case controlled study
ConclusionsPatients suffering with CTS may be at an increased risk of depression. Experiencing pain in CTS may further increase the likelihood of experiencing mental health difficulties. Poor mental health can give rise to functional symptoms, similar to those seen in CTS, demonstrating the need for electrophysiological testing before considering surgical intervention. (Source: Brain and Behavior)
Source: Brain and Behavior - June 17, 2019 Category: Neurology Authors: Lucy Moira McCallum, Nicholas Anthony Damms, Ptolemaios Georgios Sarrigiannis, Panagiotis Zis Tags: ORIGINAL RESEARCH Source Type: research

Video consultations in medication overuse headache. A randomized controlled trial
The effect of video consultations is noninferior to traditional consultations in managing medication overuse headache (MOH) patients. Using video may be a good alternative in consulting patients with MOH. AbstractObjectiveTo test the hypothesis that the effect of video consultations is noninferior to traditional consultations in managing patients with overuse headache (MOH).Materials and MethodsPatients were recruited from referrals to a neurological clinic. In a randomized controlled trial (RCT), headache burden measured by headache impact test (HIT ‐6) and frequency of headache days
Source: Brain and Behavior - June 17, 2019 Category: Neurology Authors: Svein I. Bekkelund, Kai I. M üller Tags: ORIGINAL RESEARCH Source Type: research

Plasma Brain ‐Derived Neurotrophic Factor (BDNF) and serum cortisol levels in a sample of workers exposed to occupational stress and suffering from Adjustment Disorders
ConclusionsBDNF could play a key role in the pathophysiology of stress ‐related disorders and its peripheral levels elevation could contribute to protect neurons under stress. Further research is needed focusing on biomarkers for stress‐related disorders as a potential tool for the diagnosis and prevention of occupational diseases. (Source: Brain and Behavior)
Source: Brain and Behavior - June 14, 2019 Category: Neurology Authors: Rodolfo Buselli, Antonello Veltri, Sigrid Baldanzi, Riccardo Marino, Alessandra Bonotti, Martina Chiumiento, Michelle Girardi, Luca Pellegrini, Giovanni Guglielmi, Liliana Dell'Osso, Alfonso Cristaudo Tags: ORIGINAL RESEARCH Source Type: research

Genetic association analysis of 5 ‐HTR2A gene variants in eating disorders in a Mexican population
ConclusionOur results showed an association of rs6311 (A1438G) polymorphism of5 ‐HTR2A gene with eating disorders, and these polymorphic variants could increase the risk of psychiatric comorbidities. However, more studies are required to replicate the results and to reach to a conclusive association between eating disorders and rs6311. (Source: Brain and Behavior)
Source: Brain and Behavior - June 14, 2019 Category: Neurology Authors: Alma Delia Genis ‐Mendoza, David Ruiz‐Ramos, María Lilia López‐Narvaez, Carlos Alfonso Tovilla‐Zárate, Ana Rosa García, Gabriela Cortes Meda, José Jaime Martinez‐Magaña, Thelma Beatriz González‐Castro, Isela Esther Juárez‐Roj Tags: ORIGINAL RESEARCH Source Type: research

Sentence processing is modulated by the current linguistic environment and a priori information: An fMRI study
ConclusionIn conclusion, (1) beyond the canonical language network, brain areas engaged in prediction and error signaling, such as the ACC, might use the statistics of syntactic structures to modulate language processing, (2) the language network is directly engaged in processing verb preferences. These two networks show distinct influences on sentence processing. (Source: Brain and Behavior)
Source: Brain and Behavior - June 14, 2019 Category: Neurology Authors: Kirsten Weber, Cristiano Micheli, Esther Ruigendijk, Jochem W. Rieger Tags: ORIGINAL RESEARCH Source Type: research

Epidemiology of neuromyelitis optica spectrum disorder in Denmark (1998 –2008, 2007–2014)
Differences in accuracy of NMOSD diagnosis, completeness of case ascertainment and variability in assays for AQP4 ‐IgG affect epidemiological studies of NMOSD. Data from two epidemiological studies in two decades from Denmark reflect the complexity. The increased recognition of NMOSD may facilitate prospective epidemiological studies with standardized methodologies that will enable specific conclusions. AbstractEpidemiological studies of the uncommon disorder neuromyelitis optica spectrum disorder(NMOSD) may be difficult to interpret because of the evolving nature of diagnostic criteria, differences in the definition and...
Source: Brain and Behavior - June 11, 2019 Category: Neurology Authors: Nasrin Asgari, Soeren T. Lillevang, Hanne P. B. Skejoe, Kirsten O. Kyvik Tags: ORIGINAL RESEARCH Source Type: research

Conversion and reversion of anti ‐John Cunningham virus antibody serostatus: A prospective study
ConclusionLong ‐term anti‐JCV antibody status, including seroconverters/‐reverters around the cut‐off index, is highly predictable by testing three times within short intervals, however, we cannot suggest clearly defined intervals for repetitive testing. The rate of real seroconverters, i.e., new infection s with JCV, per year seems lower than previously described. (Source: Brain and Behavior)
Source: Brain and Behavior - June 6, 2019 Category: Neurology Authors: Michael Auer, Harald Hegen, Johann Sellner, Katrin Oppermann, Gabriel Bsteh, Franziska Di Pauli, Thomas Berger, Florian Deisenhammer Tags: ORIGINAL RESEARCH Source Type: research

Identification of key genes and upstream regulators in ischemic stroke
ConclusionsThe dysregulation of these six genes may involve with the process of ischemic stroke (IS). Four TFs (PAX4,POU2F1,ELK1 andNKX2 ‐5) were concluded to play a role in IS. Our finding provided clues for exploring mechanism and developing novel diagnostic and therapeutic strategies for IS. (Source: Brain and Behavior)
Source: Brain and Behavior - June 6, 2019 Category: Neurology Authors: Qian Zhang, Wenjie Chen, Siqia Chen, Shunxian Li, Duncan Wei, Wenzhen He Tags: ORIGINAL RESEARCH Source Type: research

Disruptions of the olfactory and default mode networks in Alzheimer's disease
ConclusionsThe results provide in vivo evidence for selective vulnerability of ON and DMN in AD and significantly improves the viable clinical applications of olfactory testing. A network ‐based approach, focusing on network integrity rather than focal pathology, seems beneficial to olfactory prediction of dementia in AD. (Source: Brain and Behavior)
Source: Brain and Behavior - June 4, 2019 Category: Neurology Authors: Jiaming Lu, Qing X. Yang, Han Zhang, Paul J. Eslinger, Xin Zhang, Sichu Wu, Bing Zhang, Bin Zhu, Prasanna R. Karunanayaka Tags: ORIGINAL RESEARCH Source Type: research

Prevalence of fragile X ‐associated tremor/ataxia syndrome: A survey of essential tremor patients with cerebellar signs or extrapyramidal signs
ConclusionsTwo (2.7%) of 74 patients with presumed ET and additional neurological features were discovered to have FXTAS. The possibility of FXTAS should be considered in patients with ET who exhibit mild cerebellar signs or EPS. (Source: Brain and Behavior)
Source: Brain and Behavior - June 3, 2019 Category: Neurology Authors: Ji ‐Hyung Park, Wooyoung Jang, Jinyoung Youn, Chang‐Seok Ki, Byoung Joon Kim, Hee‐Tae Kim, Elan D. Louis, Jin Whan Cho Tags: ORIGINAL RESEARCH Source Type: research

Neural correlates of appreciating natural landscape and landscape garden: Evidence from an fMRI study
ConclusionsResponses in these regions indicate that the appreciation of landscape gardens and natural landscapes relies on common cortical regions, and suggest the possibility that the inferior occipital lobe, the SPL, the fusiform gyrus, and the cuneus may be specifically associated with the appreciation of landscape gardens. (Source: Brain and Behavior)
Source: Brain and Behavior - June 1, 2019 Category: Neurology Authors: Wei Zhang, Xianyou He, Sizhe Liu, Ting Li, Jinhui Li, Xiaoxiang Tang, Shuxian Lai Tags: ORIGINAL RESEARCH Source Type: research

Differences between physicians ’ and nurse practitioners’ viewpoints on reasons for clozapine underprescription
ConclusionsWe conclude that slight differences exist between physicians ’ and nurse practitioners’ viewpoints on patient‐related and prescriber‐related reasons for CLZ underprescription. Future research projects should involve patients to elucidate whether the patient‐related factors put forward by prescribers align with the patients’ opinions. (Source: Brain and Behavior)
Source: Brain and Behavior - May 29, 2019 Category: Neurology Authors: Cynthia Okhuijsen ‐Pfeifer, Dan Cohen, Jan P. A. M. Bogers, Cato M. H. Vos, Elianne A. H. Huijsman, René S. Kahn, Jurjen J. Luykx Tags: ORIGINAL RESEARCH Source Type: research

Prognostic factors for permanent neurological dysfunction after total aortic arch replacement with regional cerebral oxygen saturation monitoring
ConclusionIntraoperative ΔrSO2min that is lower than the basal level of about 80%, advanced age, preoperative low platelet count, and prolonged hemostasis time are predictors of PND after total aortic arch replacement. (Source: Brain and Behavior)
Source: Brain and Behavior - May 29, 2019 Category: Neurology Authors: Ying Yu, Yi Lyu, Lin Jin, Liying Xu, Huilin Wang, Yan Hu, Yun Ren, Kefang Guo Tags: ORIGINAL RESEARCH Source Type: research

Altered amplitude of low ‐frequency fluctuation in basal ganglia correlates to pulmonary ventilation function in COPD patients: A resting‐state fMRI study
ConclusionsCOPD patients mainly exhibit impaired executive function but not long ‐term memory in cognitive function assessment. Aberrant ALFF alteration in the deep brain may be directly related to lower PaO2 in COPD patients. (Source: Brain and Behavior)
Source: Brain and Behavior - May 29, 2019 Category: Neurology Authors: Chun ‐Qiang Lu, Weiwei Xu, Chu‐Hui Zeng, Lu‐Yao Ge, Yuan‐Cheng Wang, Xiang‐Pan Meng, Qian Yu, Di Wu, Shenghong Ju Tags: ORIGINAL RESEARCH Source Type: research

Hippocampal transcriptome reveals novel targets of FASD pathogenesis
Chronic binge alcohol exposure during pregnancy dysregulates fetal hippocampal gene expression in a sex ‐specific manner. Identification of subtle, transcriptome‐level dysregulation in hippocampal molecular pathways offers potential mechanistic insights underlying FASD pathogenesis. AbstractIntroductionPrenatal alcohol exposure can contribute to fetal alcohol spectrum disorders (FASD), characterized by a myriad of developmental impairments affecting behavior and cognition. Studies show that many of these functional impairments are associated with the hippocampus, a structure exhibiting exquisite vulnerability to develo...
Source: Brain and Behavior - May 29, 2019 Category: Neurology Authors: Raine Lunde ‐Young, Josue Ramirez, Vishal Naik, Marcus Orzabal, Jehoon Lee, Kranti Konganti, Andrew Hillhouse, David Threadgill, Jayanth Ramadoss Tags: ORIGINAL RESEARCH Source Type: research

Mental fatigue assessment may add information after aneurysmal subarachnoid hemorrhage
Mental fatigue, as part of cognitive dysfunction, has been reported to be common after aneurysmal subarachnoid hemorrhage and it significantly affects quality of life. The Mental Fatigue Scale score was significantly correlated to the Extended Glasgow Outcome Scale (GOSE) score. Patients with GOSE 5 ‐7 could benefit from assessments of mental fatigue in order to receive satisfactory rehabilitation. AbstractBackgroundMental fatigue, as part of cognitive dysfunction, has been reported to be common after subarachnoid hemorrhage and it significantly affects quality of life.Aims of the StudyThe aim of this study was to assess...
Source: Brain and Behavior - May 21, 2019 Category: Neurology Authors: Ann S örbo, Ingrid Eiving, Pia Löwhagen Hendén, Silvana Naredi, Johan Ljungqvist, Helena Odenstedt Hergès Tags: ORIGINAL RESEARCH Source Type: research

A homozygous mutation of alanyl ‐transfer RNA synthetase 2 in a patient of adult‐onset leukodystrophy: A case report and literature review
ConclusionsOur data provide further evidence that mutations ofAARS2 are implicated in adult ‐onset leukodystrophy. (Source: Brain and Behavior)
Source: Brain and Behavior - May 20, 2019 Category: Neurology Authors: Jian ‐Yong Wang, Song‐Fang Chen, Hong‐Qiu Zhang, Meng‐Yan Wang, Jian‐Hong Zhu, Xiong Zhang Tags: ORIGINAL RESEARCH Source Type: research

Pharmacokinetic changes and therapeutic drug monitoring of lamotrigine during pregnancy
Pregnancy influences the pharmacokinetics of lamotrigine. A reduction in ratio to target concentration (RTC) leads to worsening seizures. RTC  
Source: Brain and Behavior - May 18, 2019 Category: Neurology Authors: Ye Ding, Xiaoping Tan, Shuo Zhang, Yang Guo Tags: ORIGINAL RESEARCH Source Type: research

Effect of intraoperative infusion of dexmedetomidine on postoperative recovery in patients undergoing endovascular interventional therapies: A prospective, randomized, controlled trial
ConclusionsDexmedetomidine (an initial dose of 0.5 μg/kg for 10 min adjusted to 0.6 μg kg−1 hr−1 throughout EIT) could reduce the total consumption of nimodipine and opioid during the first 48 hr after surgery, the concerning adverse effects, and improve pain scores. The optimal dosage of dexmedetomidine during EITs merits further investigation. (Source: Brain and Behavior)
Source: Brain and Behavior - May 17, 2019 Category: Neurology Authors: Chunguang Ren, Huiying Xu, Guangjun Xu, Lei Liu, Guoying Liu, Zongwang Zhang, Jun-Li Cao Tags: ORIGINAL RESEARCH Source Type: research

AKT1, PRDM4, and BAX are  the natural markers of psychological endurance threshold
ConclusionsThe significance of this study is to discover people with abnormal expression of AKT1, PRDM4, and BAX who have lower PET and tend to commit abnormal behavior more easily. Understanding PET will enable people to make self ‐adjustment or to intervene by professionals as soon as possible and in a timely manner in the face of various negative stimuli in work and life, especially for people with lower PET, people should intervene as early as possible to reduce the harm to the individual, family and society. (Source: Brain and Behavior)
Source: Brain and Behavior - May 16, 2019 Category: Neurology Authors: Zhijian Xu, Qicheng Jing, Houcan Zhang, Yue Liu Tags: ORIGINAL RESEARCH Source Type: research

Hippocampal involvement in nonpathological d éjà vu: Subfield vulnerability rather than temporal lobe epilepsy equivalent
Brain and Behavior, Volume 9, Issue 5, May 2019. (Source: Brain and Behavior)
Source: Brain and Behavior - May 15, 2019 Category: Neurology Authors: Eva Pe šlová, Radek Mareček, Daniel J. Shaw, Tomáš Kašpárek, Martin Pail, Milan Brázdil Tags: CORRIGENDUM Source Type: research

Cover Image
The cover image is based on the Original ArticleA clinical case ‐control comparison of epidermal innervation density in Rett syndrome by Frank J. Symons et al., DOI:10.1002/brb3.1285. (Source: Brain and Behavior)
Source: Brain and Behavior - May 15, 2019 Category: Neurology Authors: Frank J. Symons, Chantel C. Barney, Breanne J. Byiers, Brian D. McAdams, Shawn X. Y. L. Foster, Timothy J. Feyma, Gwen Wendelschafer ‐Crabb, William R. Kennedy Tags: COVER IMAGE Source Type: research

Issue Information
Brain and Behavior, Volume 9, Issue 5, May 2019. (Source: Brain and Behavior)
Source: Brain and Behavior - May 15, 2019 Category: Neurology Tags: ISSUE INFORMATION Source Type: research

The activated newborn neurons participate in enriched environment induced improvement of locomotor function in APP/PS1 mice
ConclusionsThese results indicate that the activation of newborn neurons may participate in the improvement of behavioral performance in APP/PS1 mice after EE. (Source: Brain and Behavior)
Source: Brain and Behavior - May 15, 2019 Category: Neurology Authors: Hualong Wang, Qiongqiong Li, Huidong Tang, Jianqing Ding, Nanjie Xu, Suya Sun, Shengdi Chen Tags: ORIGINAL RESEARCH Source Type: research

The neural and genetic correlates of satisfying sexual activity in heterosexual pair ‐bonds
ConclusionsSatisfying sexual activity in pair ‐bonds is associated with activation of subcortical structures that support basic motivational and physiological processes; as well as cortical regions that mediate complex thinking, empathy, and self‐other processes highlighting the multifaceted role of sex in pair‐bonds.Oxtr andAvpr gene variants may further amplify  both basic and complex neural processes for pair‐bond conservation and well‐being. (Source: Brain and Behavior)
Source: Brain and Behavior - May 14, 2019 Category: Neurology Authors: Bianca P. Acevedo, Michael J. Poulin, Glenn Geher, Scott Grafton, Lucy L. Brown Tags: ORIGINAL RESEARCH Source Type: research

Maternal stress and adolescent brain structure and function
ConclusionsGiven the finding of maternal stress reactivity related to adolescent mPFC function —an integral structure related to stress responses—parent stress may play a role in the development of neural stress systems in adolescence, with potential implications for development of psychopathology. (Source: Brain and Behavior)
Source: Brain and Behavior - May 14, 2019 Category: Neurology Authors: Claire E. Niehaus, Tara M. Chaplin, Stefanie F. Gon çalves, Robin Semelsberger, James C. Thompson Tags: ORIGINAL RESEARCH Source Type: research

Variants in matrix metalloproteinase ‐9 gene are associated with hemorrhagic transformation in acute ischemic stroke patients with atherothrombosis, small artery disease, and cardioembolic stroke
ConclusionIncidence of HT is common in acute IS in Chinese population. The mechanisms leading to HT are most likely multifactorial. Two ‐loci interactions of rs3918242 and rs3787268 inMMP ‐9 gene may confer a higher risk for HT. (Source: Brain and Behavior)
Source: Brain and Behavior - May 10, 2019 Category: Neurology Authors: Xingyang Yi, Guo Sui, Qiang Zhou, Chun Wang, Jing Lin, Zhenxiao Chai, Ju Zhou Tags: ORIGINAL RESEARCH Source Type: research