Visual hallucinations and inferior longitudinal fasciculus in Parkinson's disease
ConclusionsOur results suggest that disruption of left inferior longitudinal fasciculus integrity is associated with visual hallucinations in patients with PD, independent of cognitive impairment and disease duration. (Source: Brain and Behavior)
Source: Brain and Behavior - October 20, 2020 Category: Neurology Authors: Natsuko Yuki, Akira Yoshioka, Ryo Mizuhara, Tadashi Kimura Tags: ORIGINAL RESEARCH Source Type: research

Number line estimation and standardized test performance: The left digit effect does not predict SAT math score
ConclusionsThese findings provide further evidence that individual digits strongly influence estimation performance and suggest that this effect may have different cognitive contributors, and predict different complex skills, than overall NLE accuracy. (Source: Brain and Behavior)
Source: Brain and Behavior - October 19, 2020 Category: Neurology Authors: Katherine Williams, Joanna Paul, Alexandra Zax, Hilary Barth, Andrea L. Patalano Tags: ORIGINAL RESEARCH Source Type: research

Disordered eating and internalizing symptoms in preadolescence
This study examined the associations between disordered eating, anxiety, and depression in 213 preadolescents using self ‐report questionnaires. There were strong associations between anxiety, depression, and disordered eating, and no gender differences present. These findings highlight the importance of early detection for disordered eating behaviors and attitudes, as well as anxiety and depression in both boys and girls during preadolescence. AbstractObjectivesResearch has demonstrated links between disordered eating, anxiety, and depression in adults and adolescents but there is limited research investigating these as...
Source: Brain and Behavior - October 19, 2020 Category: Neurology Authors: Kai S. Thomas, Marc O. Williams, Ross E. Vanderwert Tags: ORIGINAL RESEARCH Source Type: research

Identification of selection and inhibition components in a Go/NoGo task from EEG spectra using a machine learning classifier
ConclusionThis time –frequency‐based classifier extends previous spatiotemporal findings and provides information about neural mechanisms underlying selection and inhibition processes engaged in Go and NoGo trials, respectively. This neural network classifier can be used to assess time–frequency patterns from an individual subject and thus may offer insight into therapeutic uses of neuromodulation in neural dysfunction. (Source: Brain and Behavior)
Source: Brain and Behavior - October 19, 2020 Category: Neurology Authors: Bambi L. DeLaRosa, Jeffrey S. Spence, Michael A. Motes, Wing To, Sven Vanneste, Michael A. Kraut, John Hart Tags: ORIGINAL RESEARCH Source Type: research

Altered third ‐party punishment in Huntington's disease: A study using neuroeconomic games
ConclusionsHD seems to be associated with impairments in understanding of more complex rules of social exchange. Aside from deficits in executive functioning, this behavior could, in part, be linked to an inability to experience third ‐party punishment as rewarding. (Source: Brain and Behavior)
Source: Brain and Behavior - October 18, 2020 Category: Neurology Authors: Martin Br üne, Sarah Maria Hein, Christian Claassen, Rainer Hoffmann, Carsten Saft Tags: ORIGINAL RESEARCH Source Type: research

CD200 ‐CD200R1 signaling pathway regulates neuroinflammation after stroke
ConclusionsThe CD200 ‐CD200R1 signaling pathway regulates neuroinflammation after stroke. Stimulation of CD200R1 by CD200Fc promotes the anti‐inflammatory response and alleviates ischemic injury. (Source: Brain and Behavior)
Source: Brain and Behavior - October 17, 2020 Category: Neurology Authors: Shou ‐cai Zhao, Xu Heng, Wang Ya‐ping, Luan Di, Wu Wen‐qian, Ma Ling‐song, Zhao‐hu Chu, Yang Xu Tags: ORIGINAL RESEARCH Source Type: research

Mental health of medical personnel during the COVID ‐19 pandemic
ConclusionOur findings suggest that frontline medical personnel is under an increased psychological burden during the COVID ‐19 pandemic, having higher levels of stress, anxiety, and depression than second‐line medical personnel. Adequate measures should be taken to relieve this burden and preserve the mental health of frontline medical personnel. (Source: Brain and Behavior)
Source: Brain and Behavior - October 17, 2020 Category: Neurology Authors: Jovana Antonijevic, Iva Binic, Olivera Zikic, Snezana Manojlovic, Suzana Tosic ‐Golubovic, Nikola Popovic Tags: ORIGINAL RESEARCH Source Type: research

Shorter recovery times and better cognitive function —A comparative pilot study of magnetic seizure therapy and electroconvulsive therapy in patients with depressive episodes
The efficacy and cognitive effects between MST and bifrontal ECT for treating patients with depressive episodes were compared. Both MST and ECT improved the patients ’ depressive symptoms significantly. MST showed similar efficacy to bifrontal ECT for treating depressive episodes and may be an alternative to ECT. AbstractIntroductionMagnetic seizure therapy (MST) is a new convulsive therapy that is as effective as traditional electroconvulsive therapy (ECT) in treating depression but with fewer cognitive side effects. The aim of this study was to compare the efficacy and cognitive effects between MST (100  Hz ap...
Source: Brain and Behavior - October 17, 2020 Category: Neurology Authors: Junyan Zhang, Yanping Ren, Wei Jiang, Jiong Luo, Fang Yan, Yilang Tang, Xin Ma Tags: ORIGINAL RESEARCH Source Type: research

Association between GPx ‐1 polymorphisms and personality traits in healthy Chinese‐Han subjects
This study is the first to thoroughly investigate associations between GPx ‐1 polymorphisms and personality traits. Our results demonstrated that rs1050450 was significantly associated with the disorderliness trait. The rs1800668 polymorphism in GPx‐1 affected the personality trait of impulsiveness in healthy Chinese‐Han subjects. AbstractObjectivesCloninger developed the three ‐dimensional personality theory and Tridimensional Personality Questionnaire (TPQ), which shows that some dimensions of personality traits are heritable and related to neurotransmitters including dopamine. glutathione peroxidase 1 (GPx1) pla...
Source: Brain and Behavior - October 17, 2020 Category: Neurology Authors: Xiaojun Shao, Dongxue Sun, Bihui Zhang, Lingfei Cheng, Ci Yan, Gang Zhu Tags: ORIGINAL RESEARCH Source Type: research

What it takes to be at the top: The interrelationship between chronic social stress and social dominance
ConclusionThese results suggest that the response to CSDS did not determine social rank in new cohorts, but low ‐status mice in newly established groups exhibited lower sociability to novel social targets. Interestingly, exposure of a hierarchical social group to chronic social stress led to stress susceptibility in both high‐ and low‐status mice as measured by social interaction. (Source: Brain and Behavior)
Source: Brain and Behavior - October 17, 2020 Category: Neurology Authors: Merima Šabanović, He Liu, Vongai Mlambo, Hala Aqel, Dipesh Chaudhury Tags: ORIGINAL RESEARCH Source Type: research

Sex differences in underweight and body mass index in Chinese early de novo patients with Parkinson's disease
(PD) have not been investigated before, our study suggests that there are significant sex differences in the prevalence of underweight, body mass index (BMI), and factors associated with underweight and BMI among de novo PD patients; therefore, sex ‐specific management strategies such as dietary structure, physical activity, and nutritional status interventions may have certain clinical significance for improving life quality and prognosis of patients. AbstractObjectiveThere have been studies investigating sex differences in clinical manifestation of Parkinson's disease (PD). However, sex differences in underweight and ...
Source: Brain and Behavior - October 16, 2020 Category: Neurology Authors: Qing Wu, Meizhen Liu, Ming Yu, Jianfei Fu Tags: ORIGINAL RESEARCH Source Type: research

Health promotion intervention for people with early ‐stage dementia: A quasi‐experimental study
ConclusionThis study demonstrates promising results with regard to the benefit of attending a 12 ‐week health promotion intervention in promoting health and well‐being in people with early‐stage dementia. With the majority of participants with early‐stage dementia living at home without any healthcare services in a vulnerable stage of the condition, this study makes an important contrib ution to highlighting the need for, and benefit of, educational approaches for this population. (Source: Brain and Behavior)
Source: Brain and Behavior - October 16, 2020 Category: Neurology Authors: Ingelin Testad, Martine Kajander, Martha T. Gjestsen, Ingvild Dalen Tags: ORIGINAL RESEARCH Source Type: research

Role of densin ‐180 in mouse ventral hippocampal neurons in 24‐hr retention of contextual fear conditioning
ConclusionThis study shows that vHC densin ‐180 is necessary for stCFC memory formation and retrieval and suggests that both densin‐180 and p‐T305 CaMKIIα at 1 ~ 2 hr postshock are important for stCFC memory formation. We conclude that roles of hippocampal neuronal densin‐180 in CFC are temporally dynamic and differential dependi ng on the pattern of conditioning stimuli and its location along the dorsoventral axis of hippocampal formation. (Source: Brain and Behavior)
Source: Brain and Behavior - October 16, 2020 Category: Neurology Authors: Chong ‐Hyun Kim, Seoyul Kim, Su‐Hyun Kim, Jongtae Roh, Harin Jin, Bokyung Song Tags: ORIGINAL RESEARCH Source Type: research

Issue Information
Brain and Behavior, Volume 10, Issue 10, October 2020. (Source: Brain and Behavior)
Source: Brain and Behavior - October 15, 2020 Category: Neurology Tags: ISSUE INFORMATION Source Type: research

Intact microstructure of the right corticostriatal pathway predicts creative ability in healthy adults
ConclusionOur results put a further spin on the “creative right brain” notion and question the presence of high‐creative and low‐creative networks in the brain. (Source: Brain and Behavior)
Source: Brain and Behavior - October 15, 2020 Category: Neurology Authors: Farzaneh Rahmani, Hossein Sanjari Moghaddam, Mohammad Hadi Aarabi Tags: ORIGINAL RESEARCH Source Type: research

Prognostic significance of early systolic blood pressure variability after endovascular thrombectomy and intravenous thrombolysis in acute ischemic stroke: A systematic review and meta ‐analysis
The present study provided evidence that increased early SBPV after EVT is related to worse longer ‐term functional outcome in AIS, but the association is not significant in AIS patients treated with IVT. Furthermore, individualized BP management strategies were essential for AIS patients after EVT or IVT. AbstractObjectivesPrevious studies have shown inconsistent results regarding the effect of early systolic blood pressure variability (SBPV) after endovascular thrombectomy (EVT) and intravenous thrombolysis (IVT) on functional outcome in acute ischemic stroke (AIS). Thesystematic review and meta ‐analysis aimed to de...
Source: Brain and Behavior - October 14, 2020 Category: Neurology Authors: Jingcui Qin, Zhijun Zhang Tags: ORIGINAL RESEARCH Source Type: research

Vitamin D levels are associated with trait resilience but not depression in a general population sample
We found that resilience, but not depression, was strongly associated with vitamin D levels in 1,908 subjects from the general population. The association with resilience remained stable after adjustment for depressive symptoms. Functional polymorphisms of the vitamin D ‐binding protein gene (rs4588 and rs7041) were highly associated with vitamin D levels, but neither depression nor resilience. AbstractIntroductionInsufficient vitamin D levels were found to be related to various psychiatric disorders and particularly depression. The functional polymorphisms rs4588 and rs7041 of the vitamin D ‐binding protein (alsogroup...
Source: Brain and Behavior - October 13, 2020 Category: Neurology Authors: Jan Terock, Anke Hannemann, Deborah Janowitz, Jasmin M üller, Henry Völzke, Hans J. Grabe Tags: ORIGINAL RESEARCH Source Type: research

Dihydrotestosterone in Amyotrophic lateral sclerosis —The missing link?
ConclusionsDHT is probably integral to survival of motor neurons. In patients predisposed to develop ALS, there is possibly a sort of “testosterone resistance” at level of blood–brain barrier [BBB] existing right from birth and is likely the result of dysfunctional transport protein involved in testosterone transfer across the BBB. In these patients, lesser amount of testosterone is able to breach the BBB and enter the centr al neural axis. Lesser amount of testosterone is available to 5 α reductase in the anterior pituitary to be converted to DHT and lesser amount of DHT is generated. There is inad...
Source: Brain and Behavior - October 13, 2020 Category: Neurology Authors: Nishit Sawal, Jasbinder Kaur, Kamaljeet Kaur, Satinder Gombar Tags: ORIGINAL RESEARCH Source Type: research

Effect of perioperative intravenous lidocaine on the incidence of short ‐term cognitive function after noncardiac surgery: A meta‐analysis based on randomized controlled trials
ConclusionsCurrent evidence cannot suggest that perioperative intravenous use of lidocaine has pharmacological brain neuroprotection after noncardiac surgery. All the included studies were small ‐scale research, and the total number of participants was small; the results should be interpreted with caution. (Source: Brain and Behavior)
Source: Brain and Behavior - October 12, 2020 Category: Neurology Authors: Xiao Huang, Yuan Sun, Dandan Lin, Changwei Wei, Anshi Wu Tags: REVIEW Source Type: research

Associations between brain ‐derived neurotrophic factor and cognitive impairment in panic disorder
This is a study focusing on associations between Brain ‐Derived Neurotrophic Factor (BDNF) single nucleotide polymorphism, plasma Levels, and cognitive impairment in Chinese patients with panic disorder (PD).We found the BDNF Met/Met genotype may be associated with lower BDNF plasma levels and some domains of cognitive impairments in PD patients. AbstractIntroductionOur study was designed to examine the relationship between Brain ‐Derived Neurotrophic Factor (BDNF) genotypes (rs6265, Val66Met), BDNF plasma levels, and cognitive impairment in Chinese patients with panic disorder (PD).MethodsTotal 85 patients with PD and...
Source: Brain and Behavior - October 12, 2020 Category: Neurology Authors: Wenchen Wang, Yuanyuan Liu, Shuqing Luo, Xiaoyun Guo, Xingguang Luo, Yong Zhang Tags: ORIGINAL RESEARCH Source Type: research

Occurrence of postdural puncture headache —A randomized controlled trial comparing 22G Sprotte and Quincke
ConclusionsThe use of 22GS halves the risk of PDPH compared with 22GQ. This study provides strong support to make a change in practice where traumatic needles are still in regular use. (Source: Brain and Behavior)
Source: Brain and Behavior - October 12, 2020 Category: Neurology Authors: Ane Skaare Sjulstad, Francis Odeh, Farid K. Baloch, Diana Hristova Berg, Kathrine Arntzen, Karl B. Alstadhaug Tags: ORIGINAL RESEARCH Source Type: research

Adjunctive bright light therapy for treating bipolar depression: A systematic review and meta ‐analysis of randomized controlled trials
ConclusionsBright light therapy is an effective treatment for reducing depression symptoms among patients with bipolar depression. (Source: Brain and Behavior)
Source: Brain and Behavior - October 9, 2020 Category: Neurology Authors: Hirofumi Hirakawa, Takeshi Terao, Masaaki Muronaga, Nobuyoshi Ishii Tags: REVIEW Source Type: research

Longitudinal analysis of brain structure using existence probability
ConclusionThese results showed that the proposed method is effective for the early detection of AD and MCI. (Source: Brain and Behavior)
Source: Brain and Behavior - October 9, 2020 Category: Neurology Authors: Norihide Maikusa, Tadanori Fukami, Hiroshi Matsuda, The Japanese Alzheimer ’s Disease Neuroimaging Initiative (J‐ADNI) Tags: ORIGINAL RESEARCH Source Type: research

Effects of white noise in walking on walking time, state anxiety, and fear of falling among the elderly with mild dementia
This study aimed to analyze the effects of white noise in walking on the walking time, state anxiety, and fear of falling of the elderly with mild dementia.MethodsSubjects were 32 elderlies with mild dementia, and they divided into experimental group and control group, respectively. In the experimental group, walking program with white noise was applied 3 times a week for 4  weeks. White noise was provided by white noise generator in walking program. In the control group, walking program only was applied. To measure the effect of white noise in walking among the subjects, the walking time, state anxiety, and fear of f...
Source: Brain and Behavior - October 9, 2020 Category: Neurology Authors: Sung ‐min Son, Sung‐won Kwag Tags: ORIGINAL RESEARCH Source Type: research

Pathways from health beliefs to treatment utilization for severe depression
ConclusionsThe HBM may be useful to predict the frequency of seeking treatment by individuals for depression. However, individualized intervention strategies targeting different aspects of the HBM are needed to promote help ‐seeking behaviors in young adults with depression. (Source: Brain and Behavior)
Source: Brain and Behavior - October 7, 2020 Category: Neurology Authors: Flavius R. W. Lilly, Hyun ‐Jin Jun, Patty Alvarez, Jenny Owens, Lauren Malloy, Meghan Bruce‐Bojo, Carol Vidal Tags: ORIGINAL RESEARCH Source Type: research

The diagnostic potential of multimodal neuroimaging measures in Parkinson's disease and atypical parkinsonism
ConclusionWe suggest the fusion of multimodal neuroimaging measures as an effective strategy that could generally cope with diverse prediction problems of clinical concerns. (Source: Brain and Behavior)
Source: Brain and Behavior - October 7, 2020 Category: Neurology Authors: Chang ‐hyun Park, Phil Hyu Lee, Seung‐Koo Lee, Seok Jong Chung, Na‐Young Shin Tags: ORIGINAL RESEARCH Source Type: research

Cognitive impairment in NMOSD —More questions than answers
ConclusionPatients with NMOSD are at significant risk of cognitive deficits. However, the knowledge of cognitive symptoms in NMOSD and potential modifying interventions is still scarce. Further accumulation of clinical data may facilitate effective therapeutic interventions. (Source: Brain and Behavior)
Source: Brain and Behavior - October 6, 2020 Category: Neurology Authors: Dominika Czarnecka, Magdalena Oset, Iwona Karli ńska, Mariusz Stasiołek Tags: REVIEW Source Type: research

A survey of lifestyle factors in dystonia
ConclusionsConclusions on causality cannot be drawn in this preliminary study, further research is encouraged regarding the link between smoking and dystonia. (Source: Brain and Behavior)
Source: Brain and Behavior - October 6, 2020 Category: Neurology Authors: Jacob S öderlund, Dag Nyholm Tags: ORIGINAL RESEARCH Source Type: research

The changed functional status of the brain was involved in patients with poststroke aphasia: Coordinate ‐based (activation likelihood estimation) meta‐analysis
Although the underlying pathophysiological mechanism of poststroke aphasia (PSA) is greatly concerned, it remains unclear. By coordinate ‐based (ALE) meta‐analysis, we found that the activation of the left superior frontal gyrus (SFG) and the parietal postcentral gyrus of PSA presented hypoactivation, while there was hyperactivation in the right cerebellar anterior lobe, fusiform gyrus, superior temporal gyrus (STG), superior par ietal lobule (SPL), and subgyral hippocampus. It is worth noting that the changed functional status of area in brain is more involved in right lobe. The future studies on rehabilitation should...
Source: Brain and Behavior - October 5, 2020 Category: Neurology Authors: Ying Du, Yujun Lee, Chuan He, Lihan Peng, Qian Yong, Zhiyi Cen, Yuqin Chen, Xin Liu, Xiaoming Wang Tags: ORIGINAL RESEARCH Source Type: research

Verbal emotional memory laterality effect on amygdalohippocampectomy for refractory epilepsy
ConclusionsPatients with MTLE show a deficit in the verbal recall which is exacerbated for information with an affective component. This deficit is more prominent in the case of patients with left unilateral resection (MTLE ‐left group) since they lose the benefits of the emotional information for the recall. (Source: Brain and Behavior)
Source: Brain and Behavior - October 4, 2020 Category: Neurology Authors: Fernando Carvajal, Ainara Calahorra ‐Romillo, Sandra Rubio, Pilar Martín Tags: ORIGINAL RESEARCH Source Type: research

White matter abnormalities and cognitive function in euthymic patients with bipolar disorder and major depressive disorder
ConclusionsThe significant reduction of white matter integrity in the corpus callosum in BD, compared to MDD, was associated with an impairment of sustained attention. This result promotes the understanding of the significance of white matter integrity in mood disorders. (Source: Brain and Behavior)
Source: Brain and Behavior - October 2, 2020 Category: Neurology Authors: Yoshikazu Masuda, Go Okada, Masahiro Takamura, Chiyo Shibasaki, Atsuo Yoshino, Satoshi Yokoyama, Naho Ichikawa, Shiho Okuhata, Tetsuo Kobayashi, Shigeto Yamawaki, Yasumasa Okamoto Tags: ORIGINAL RESEARCH Source Type: research

Validation of the Traumatic Antecedents Questionnaire using item response theory
ConclusionsThe newly proposed scoring system and 8 domains for the TAQ demonstrated excellent internal consistency, test –retest reliability, and validity. Further studies are needed to develop new items in domains with less than 5 items to improve the psychometric properties of the scale and to create a maltreatment domain that includes bullying items. (Source: Brain and Behavior)
Source: Brain and Behavior - September 30, 2020 Category: Neurology Authors: Kyumin Park, Geumsook Shim, Bumseok Jeong Tags: ORIGINAL RESEARCH Source Type: research

Effects of childhood trauma experience and COMT Val158Met polymorphism on brain connectivity in a multimodal MRI study
In this study, we aim to see how gene × brain × environment models give a more integrative understanding of brain modifications that contribute to predicting psychopathology related to childhood adversity. A large nonclinical sample of young adults completed Childhood Trauma Questionnaire (CTQ), behavioral scores, multimodal magnetic resonance imaging (MRI) scans, and genotyping. We utilized graph‐based conne ctivity analysis in morphometric similarity mapping and resting‐state functional MRI to investigate brain alterations. Relationships among COMT genotypes, CTQ score, imaging phenoty...
Source: Brain and Behavior - September 29, 2020 Category: Neurology Authors: Tian Tian, Jia Li, Guiling Zhang, Jian Wang, Dong Liu, Changhua Wan, Jicheng Fang, Di Wu, Yiran Zhou, Wenzhen Zhu Tags: ORIGINAL RESEARCH Source Type: research

Preclinical atherosclerosis in adolescents with psychotic or bipolar disorders investigated with carotid high ‐frequency ultrasound
Adolescents with EOP or EOBP had an increased LCCA intima thickness, interpreted as a sign of preclinical atherosclerosis. Global function of the disorders was the strongest determinant of intima thickness. AbstractObjectiveEarly ‐onset psychosis (EOP) and bipolar disorder (EOBP) (at
Source: Brain and Behavior - September 29, 2020 Category: Neurology Authors: Hannes Bohman, Ingrid Agartz, Shiva Mansouri, Tord Naessen, Mathias Lundberg Tags: ORIGINAL RESEARCH Source Type: research

H258R mutation in KCNAB3 gene in a family with genetic epilepsy and febrile seizures plus
ConclusionsThese results reveal that mutations in theKCNAB3 gene may be associated with GEFS+. (Source: Brain and Behavior)
Source: Brain and Behavior - September 28, 2020 Category: Neurology Authors: Jian Ding, Qin ‐Fei Miao, Jing‐Wen Zhang, Yu‐Xiong Guo, Yu‐Xin Zhang, Qiong‐Xiang Zhai, Zhi‐Hong Chen Tags: ORIGINAL RESEARCH Source Type: research

Pathways to post ‐traumatic stress disorder and alcohol dependence: Trauma, executive functioning, and family history of alcoholism in adolescents and young adults
ConclusionFindings from this study demonstrate associations with PTSD and alcohol dependence symptom counts, as well as poor problem ‐solving ability in trauma‐exposed individuals from families densely affected with alcohol dependence, depending on trauma type, FHD, and sex. This suggests that having a FH of alcohol dependence and exposure to trauma during adolescence may be associated with more PTSD and alcohol dependence sy mptoms, and poor problem‐solving abilities in adulthood. (Source: Brain and Behavior)
Source: Brain and Behavior - September 28, 2020 Category: Neurology Authors: Stacey Subbie ‐Saenz de Viteri, Ashwini Pandey, Gayathri Pandey, Chella Kamarajan, Rebecca Smith, Andrey Anokhin, Lance Bauer, Annah Bender, Grace Chan, Danielle Dick, Howard Edenberg, Sivan Kinreich, John Kramer, Marc Schuckit, Yong Zang, Tags: ORIGINAL RESEARCH Source Type: research

Influence of resilience on the relations among acculturative stress, somatization, and anxiety in latinx immigrants
ConclusionThis study suggests that Latinx immigrants presenting with somatic symptoms may benefit from the examination of a possible comorbid presentation of anxiety or acculturative stressors. An integrated behavioral healthcare approach is recommended when working with Latinx immigrants evaluating the impact of minority stressors on health. Clinicians are encouraged to incorporate cultural protective factors that reinforce the development and sustenance of resilience. (Source: Brain and Behavior)
Source: Brain and Behavior - September 28, 2020 Category: Neurology Authors: Annahir N. Cariello, Paul B. Perrin, Alejandra Morlett ‐Paredes Tags: ORIGINAL RESEARCH Source Type: research

Deductive ‐reasoning brain networks: A coordinate‐based meta‐analysis of the neural signatures in deductive reasoning
ConclusionThe findings of the current study are consistent with the view that deductive reasoning requires a succession of stages, which included decoding of linguistic information, conversion and correction of rules, and transformation of inferential results into conclusive outputs, all of which are putatively processed via a distributed network of brain regions encompassing frontal/parietal cortices, as well as the caudate and other subcortical structures, which suggested that in the process of deductive reasoning, the coding and integration of premise information is indispensable, and it is also crucial to the execution...
Source: Brain and Behavior - September 28, 2020 Category: Neurology Authors: Li Wang, Meng Zhang, Feng Zou, Xin Wu, Yufeng Wang Tags: REVIEWS Source Type: research

Multimodal treatment of persistent postural –perceptual dizziness
ConclusionsTherapeutic principles comprise cognitive –behavioral therapy, vestibular rehabilitation exercises, and serotonergic medication. However, large‐scale, randomized, controlled trials are still missing. Follow‐up observations after multimodal interdisciplinary therapy reveal an improvement in symptoms in most patients with chronic dizzin ess. The study was not designed to detect diagnosis‐specific effects, but patients with PPPD and patients with other vestibular disorders benefit from multimodal therapies. (Source: Brain and Behavior)
Source: Brain and Behavior - September 27, 2020 Category: Neurology Authors: Hubertus Axer, Sigrid Finn, Alexander Wassermann, Orlando Guntinas ‐Lichius, Carsten M. Klingner, Otto W. Witte Tags: ARTICLE Source Type: research

High neutrophil ‐to‐lymphocyte ratio is a predictor of poor short‐term outcome in patients with mild acute ischemic stroke receiving intravenous thrombolysis
ConclusionsA high NLR on admission could be a useful marker for predicting poor short ‐term outcome in patients with mild AIS following IVT. (Source: Brain and Behavior)
Source: Brain and Behavior - September 26, 2020 Category: Neurology Authors: Yong ‐Lin Liu, Zhi‐Qiang Wu, Jian‐Feng Qu, Dong‐Hai Qiu, Gen‐Pei Luo, Han‐Peng Yin, Xue‐Wen Fang, Fang Wang, Yang‐Kun Chen Tags: ORIGINAL RESEARCH Source Type: research

Predictors of changes after reasoning training in healthy adults
Conclusion and implicationIdentifying predictors for nonpharmacological interventions may help to set up a personalized medicine approach in order to prevent cognitive decline in healthy older adults. (Source: Brain and Behavior)
Source: Brain and Behavior - September 26, 2020 Category: Neurology Authors: Mandy Roheger, Elke Kalbe, Anne Corbett, Helen Brooker, Clive Ballard Tags: ORIGINAL ARTICLE Source Type: research

Time will tell: Decision making in premanifest and manifest Huntington ’s disease
In this study, we assessed decision making in manifest Huntington's disease (HD) and premanifest HD patients. We could show that jumping to conclusions is an early marker of cognitive dysfunction in premanifest HD patients prior to reaching criteria for the motor diagnosis of HD. AbstractObjectiveTo investigate cognitive flexibility in premanifest and manifest Huntington's disease (HD).BackgroundHD is an autosomal dominant neurodegenerative disease characterized by motor, cognitive, and behavioral abnormalities with typical motor symptoms. In this study, we wanted to assess decision making in premanifest (pre ‐HD) and ma...
Source: Brain and Behavior - September 25, 2020 Category: Neurology Authors: Beatrice Heim, Marina Peball, Carsten Saft, Sarah Maria Hein, Philipp Ellmerer, Johanna Maria Piater, Klaus Seppi, Atbin Djamshidian Tags: Original Research Source Type: research

Peripheral versus central mechanisms of the cannabinoid type 2 receptor agonist AM1710 in a mouse model of neuropathic pain
Either i.p. or i.t. AM1710 reversed CCI ‐induced mechanical allodynia in CB1R (−/−), (+/−), (+/+) mice similar to sham control threshold levels. The absence of the CB1R following CCI‐induced neuropathy revealed greater significant increases in IL‐10 immunoreactivity (IR) in the dorsal root ganglia (DRG) and the dorsal horn of the spinal cord in (−/−) and (+/−) mice that was further elevated following i.t. and i.p. AM1710. The absence of CB1R may allow for enhanced tissue/axon damage‐associated signaling to the DRG and spinal cord, resulting in endogenous compensatory increases in...
Source: Brain and Behavior - September 24, 2020 Category: Neurology Authors: Jenny L. Wilkerson, Lauren B. Alberti, Audra A. Kerwin, Catherine A. Ledent, Ganesh A. Thakur, Alexandros Makriyannis, Erin D. Milligan Tags: ORIGINAL RESEARCH Source Type: research

The relationship among fear and anxiety of COVID ‐19, pregnancy experience, and mental health disorder in pregnant women: A structural equation model
ConclusionBased on the result of this study, it is necessary to pay more attention to the mental health of pregnant women during a pandemic. In addition, it is recommended to provide a virtual training group to reduce anxiety caused by coronavirus and pregnancy concerns, as well as emphasizing the feeling of enjoying happiness caused by pregnancy experience during a pandemic. (Source: Brain and Behavior)
Source: Brain and Behavior - September 22, 2020 Category: Neurology Authors: Leili Salehi, Mitra Rahimzadeh, Elham Molaei, Hamideh Zaheri, Sara Esmaelzadeh ‐Saeieh Tags: ORIGINAL RESEARCH Source Type: research

Elevated homocysteine, as a biomarker of cardiac injury, in panic disorder patients due to oxidative stress
The aim of the present study was to evaluate serum homocysteine concentration and its relationship with oxidative stress levels in patients with PD, regarding homocysteine as a diagnostic biomarker of heart disease. Our findings support that, patients with PD experience higher levels of oxidative stress, due to impaired serotonin metabolism, which is related to the prognosis of heart disease in these patients. AbstractBackground and ObjectivePatients with panic disorder (PD) suffer from elevated oxidative stress as a consequence of serotonin metabolism disorder. These patients have elevated serotonin concentration and cata...
Source: Brain and Behavior - September 22, 2020 Category: Neurology Authors: Seyed Shahrokh Aghayan, Asghar Farajzadeh, Zahra Bagheri ‐Hosseinabadi, Homeyra Fadaei, Maryam Yarmohammadi, Moslem Jafarisani Tags: ORIGINAL RESEARCH Source Type: research

Assessing differential effects of single and accelerated low ‐frequency rTMS to the visual cortex on GABA and glutamate concentrations
Conclusion: Accelerated 1 Hz rTMS to the visual cortex has greater potential for approaches targeting plasticity or in cases with altered GABAergic responses in visual disorders. Notably, these results provide preliminary insight into a critical window of p lasticity with accelerated rTMS (e.g., 24 hr) in which adjunct therapies may offer better functional outcome. We describe detailed procedures to enable further exploration of these protocols. (Source: Brain and Behavior)
Source: Brain and Behavior - September 22, 2020 Category: Neurology Authors: Sara A. Rafique, Jennifer K. E. Steeves Tags: METHODS Source Type: research

The relationship between epilepsy and cognitive function in benign childhood epilepsy with centrotemporal spikes
ConclusionThere is a trend of cognitive impairment in patients with early BECTS. This trend of cognitive impairment in early BECTS children may be related to the changes in the FC network pattern. (Source: Brain and Behavior)
Source: Brain and Behavior - September 21, 2020 Category: Neurology Authors: Yihan Li, Yulei Sun, Tingting Zhang, Qi Shi, Jintao Sun, Jing Xiang, Qiqi Chen, Zheng Hu, Xiaoshan Wang Tags: ORIGINAL RESEARCH Source Type: research

Inhibition of RNF6 alleviates traumatic brain injury by suppressing STAT3 signaling in rats
ConclusionInhibition of RNF6 alleviated TBI by suppressing the STAT3 signaling in TBI rats. (Source: Brain and Behavior)
Source: Brain and Behavior - September 20, 2020 Category: Neurology Authors: Bin Liu, Gang Zhang, Shukun Cui, Guoliang Du Tags: ORIGINAL RESEARCH Source Type: research

Patient Health Questionnaire ‐9 predicts the functional outcome of stroke patients in convalescent rehabilitation ward
This study investigated the relationship between PHQ‐9 score and functional outcomes in stroke patients in a convalescent rehabilitation ward by evaluating functional independence measure (FIM) gain scores and the proportion of patien ts discharged.MethodsIn this retrospective study conducted from January 2017 to September 2019, consecutive stroke patients who were admitted to the convalescent rehabilitation ward and could answer PHQ ‐9 were assessed. The association between PHQ‐9 scores at the time of admission to the convalescent rehabilitation ward and outcomes (FIM gain score and the proportion of patients discha...
Source: Brain and Behavior - September 19, 2020 Category: Neurology Authors: Masahiro Nakamori, Eiji Imamura, Keisuke Tachiyama, Teppei Kamimura, Yuki Hayashi, Hayato Matsushima, Hiroyuki Okamoto, Tatsuya Mizoue, Shinichi Wakabayashi Tags: ORIGINAL RESEARCH Source Type: research

Neural correlates of verbal recognition memory in obese adults with and without major depressive disorder
This study's aim was to determine how obesity impacts neural activity during a verbal recognition memory task in individuals both with and without MDD. Results indicate that obesity in conjunction with MDD confers a subtle impact on neural functioning. AbstractBackgroundObesity and major depressive disorder (MDD) independently contribute to memory impairment. Little is known about shared neural mechanisms that may result in the cognitive impairment experienced by these populations. This study's aim was to determine how obesity impacts neural activity during a verbal recognition memory task in individuals both with and with...
Source: Brain and Behavior - September 19, 2020 Category: Neurology Authors: Maria R. Restivo, Geoffrey B. Hall, Benicio N. Frey, Margaret C. McKinnon, Valerie H. Taylor Tags: ORIGINAL RESEARCH Source Type: research