Interaction between catechol ‐O‐methyltransferase polymorphism and childhood trauma in suicidal ideation of patients with post‐traumatic stress disorder
ConclusionOur results suggest that vulnerability to suicide could be increased in the Val/Val genotype ofCOMT rs4680 and the CC genotype of rs4633 in patients with PTSD. Moreover, PTSD group with high childhood emotional abuse demonstrated a significantly higher suicidal ideation than did those with low childhood emotional abuse. (Source: Brain and Behavior)
Source: Brain and Behavior - July 2, 2020 Category: Neurology Authors: Aeran Kwon, Dongil Min, Yourim Kim, Min Jin Jin, Seung ‐Hwan Lee Tags: ORIGINAL RESEARCH Source Type: research

Reproducibility of graph measures at the subject level using resting ‐state fMRI
ConclusionOur results demonstrated that normalized global graph measures based on a weighted network using the absolute (partial) correlation as weight were reproducible. The denoising pipeline and the granularity of the whole ‐brain parcellation used to define the nodes were not critical for the reproducibility of normalized graph measures. (Source: Brain and Behavior)
Source: Brain and Behavior - July 2, 2020 Category: Neurology Authors: Qian Ran, Tarik Jamoulle, Jolien Schaeverbeke, Karen Meersmans, Rik Vandenberghe, Patrick Dupont Tags: ORIGINAL RESEARCH Source Type: research

Effects of environmental tobacco smoke exposure on brain functioning in never ‐smoking adolescents
ConclusionsNevertheless, from this study, it can be concluded that low ‐to‐moderate exposure to ETS during adolescence does not result in functional brain changes related to smoking cue reactivity, inhibitory control, and reward processing. (Source: Brain and Behavior)
Source: Brain and Behavior - July 1, 2020 Category: Neurology Authors: Joyce Dieleman, Marloes Kleinjan, Roy Otten, Hein T. Schie, Vivian Heuvelmans, Maartje Luijten Tags: ORIGINAL RESEARCH Source Type: research

Effects of mirror neuron system ‐based training on rehabilitation of stroke patients
After 8 consecutive weeks ’ training, both groups showed significant improvements on the upper extremity motor function, cognitive function, and daily life ability score after training (p 
Source: Brain and Behavior - July 1, 2020 Category: Neurology Authors: Huiwen Mao, Yan Li, Li Tang, Ye Chen, Jiawei Ni, Liang Liu, Chunlei Shan Tags: ORIGINAL RESEARCH Source Type: research

Fetal eye movements in response to a visual stimulus
ConclusionThis provides evidence for visual attention mechanisms that can be controlled through eye movements that are independent of head movements prior to birth. (Source: Brain and Behavior)
Source: Brain and Behavior - July 1, 2020 Category: Neurology Authors: Tim Donovan, Kirsty Dunn, Amy Penman, Robert J. Young, Vincent M. Reid Tags: ORIGINAL RESEARCH Source Type: research

Identifying interactive biological pathways associated with reading disability
DiscussionThe behavioral and demographic factors were suggested to be protective against reading disability status, while birthweight conveyed risk. We provided supporting evidence that reading disability has a complex biological and environmental etiology and that there may be a shared genetic and neurobiological architecture for reading (dis)ability. (Source: Brain and Behavior)
Source: Brain and Behavior - June 28, 2020 Category: Neurology Authors: Hope Sparks Lancaster, Xiaonan Liu, Valentin Dinu, Jing Li Tags: ORIGINAL RESEARCH Source Type: research

High ‐frequency transcranial magnetic stimulation protects APP/PS1 mice against Alzheimer’s disease progress by reducing APOE and enhancing autophagy
ConclusionsrTMS exerts a potentially protective role in the prevention and treatment of AD by reducing ApoE expression and promoting autophagic flux, which provides a new insight into the mechanism of rTMS. (Source: Brain and Behavior)
Source: Brain and Behavior - June 26, 2020 Category: Neurology Authors: Xia Chen, Guo ‐Ying Dong, Lin‐Xiao Wang Tags: ORIGINAL RESEARCH Source Type: research

Robot ‐assisted therapy for upper‐limb rehabilitation in subacute stroke patients: A systematic review and meta‐analysis
ConclusionRobot ‐assisted therapy produced benefits similar, but not significantly superior, to those from usual care for improving functioning and disability in patients diagnosed with stroke within six months. Apart from using head‐to‐head comparison to determine the effects of RT in subacute stroke survivo rs, future studies may explore the possibility of conducting noninferiority or equivalence trials, given that the less labor‐intensive RT may offer important advantages over currently available standard care, in terms of improved convenience, better adherence, and lower manpower cost. (Source: Brain and Behavior)
Source: Brain and Behavior - June 26, 2020 Category: Neurology Authors: Wai ‐tong Chien, Yuen‐yu Chong, Man‐kei Tse, Cheuk‐woon Chien, Ho‐yu Cheng Tags: REVIEW ARTICLE Source Type: research

Relationship between insecure attachment and physical symptom severity is mediated by sensory sensitivity
ConclusionsThis study extends our understanding of the potential pathways that lead individuals with attachment insecurity to experience burdensome physical symptoms by supporting a mediating role for SPS. (Source: Brain and Behavior)
Source: Brain and Behavior - June 26, 2020 Category: Neurology Authors: Thao Lan Le, Rose Geist, Jon Hunter, Robert G. Maunder Tags: ORIGINAL RESEARCH Source Type: research

A qualitative exploration of the sociology of poststroke visual impairments and the associated health inequalities
ConclusionThe stroke survivors frequently reported a complete lack of visual care, with many recounting apathetic experiences, often resonating power imbalance in the healthcare system. Where suitable care is being offered after stroke, a desire for a personalized approach to rehabilitation, with adapted communication methods specific to individual needs, featured strongly in many of the respondent accounts. The findings emphasize a need to ensure vision rehabilitation is offered to all stroke survivors suffering from poststroke visual impairment, and to educate stroke clinicians and patients of the bigger picture of life ...
Source: Brain and Behavior - June 26, 2020 Category: Neurology Authors: Kerry Hanna, David Mercer, Fiona Rowe Tags: ORIGINAL RESEARCH Source Type: research

Altered somatosensory evoked potentials associated with improved reaction time in a simple sensorimotor response task following repetitive practice
ConclusionThe present study suggests that motor learning improves somatosensory processing and attentional allocation via neuroplasticity and that these alterations are reflected by specific SEP changes. (Source: Brain and Behavior)
Source: Brain and Behavior - June 25, 2020 Category: Neurology Authors: Mayu Akaiwa, Koki Iwata, Hidekazu Saito, Takeshi Sasaki, Kazuhiro Sugawara Tags: ORIGINAL RESEARCH Source Type: research

Neuro ‐Sjögren: Uncommon or underestimated problem?
ConclusionsPeripheral neuropathies are frequent in SS patients. Neurologists should be aware of possible autoimmune causes of neuropathies because clinical manifestations of neuropathy may precede the development of other symptoms of the autoimmune disease. (Source: Brain and Behavior)
Source: Brain and Behavior - June 25, 2020 Category: Neurology Authors: Marta Jask ólska, Magdalena Chylińska, Anna Masiak, Mariusz Siemiński, Marcin Ziętkiewicz, Zenobia Czuszyńska, Żaneta Smoleńska, Zbigniew Zdrojewski Tags: ORIGINAL RESEARCH Source Type: research

Investigating the relationship between interleukin ‐6 serum levels and outcome in acute ischemic CVA
It shows that IL ‐6 contributes to determination of severity of ischemic stroke and may be useful in predicting patient prognosis. AbstractIntroductionInterleukin ‐6 (IL‐6) is among the inflammatory mediators exhibiting elevated levels in ischemic stroke (IS) patients. The present study set out to evaluate the relationship between serum levels of interleukin‐6 with long‐term and at‐hospital outcomes of acute ischemic stroke in patients hospitalized at Imam Khomeini Hospital, Urmia, Iran, from 2017 to 2018.Method and materialsThis cross ‐sectional descriptive study enrolled 29 and 31 acute stroke patients for ...
Source: Brain and Behavior - June 25, 2020 Category: Neurology Authors: Arash Mosarrezaii, Mohammad Reza Amiri ‐Nikpour, Hamid Reza Mehryar, Babak Choobi Anzali, Sarmad Nourooz‐Zadeh, Shadi Babaei, Hedieh Farrokhi Tags: ORIGINAL RESEARCH Source Type: research

Memory deficits in Sprague Dawley rats with spontaneous ventriculomegaly
ConclusionOur results are the first to show how spontaneous ventriculomegaly ‐induced cerebral structural damage affects decision‐making behaviors, particularly when comparing between immediate and delayed trials. Moreover, this lesion disrupts the animals’ ability to recall or express contextual information. (Source: Brain and Behavior)
Source: Brain and Behavior - June 25, 2020 Category: Neurology Authors: Hiram Luna ‐Munguia, Deisy Gasca‐Martinez, Luis Marquez‐Bravo, Luis Concha Tags: ORIGINAL RESEARCH Source Type: research

Mental health status of the general population, healthcare professionals, and university students during 2019 coronavirus disease outbreak in Jordan: A cross ‐sectional study
ConclusionsDuring outbreaks, individuals are put under extreme stressful condition resulting in higher risk of developing anxiety and depression particularly for students and healthcare professionals. Policymakers and mental healthcare providers are advised to provide further mental support to these vulnerable groups during this pandemic. (Source: Brain and Behavior)
Source: Brain and Behavior - June 24, 2020 Category: Neurology Authors: Abdallah Y. Naser, Eman Zmaily Dahmash, Rabaa Al ‐Rousan, Hassan Alwafi, Hamzeh Mohammad Alrawashdeh, Imene Ghoul, Anwer Abidine, Mohammed A. Bokhary, Hadeel T. AL‐Hadithi, Dalia Ali, Rasha Abuthawabeh, Ghada Mohammad Abdelwahab, Yosra J. Tags: ORIGINAL RESEARCH Source Type: research

Differences of connectivity between ESRD patients with PD and HD
ConclusionThis study revealed that alterations in structural and functional connectivity in patients who were undergoing PD and HD were different than those in healthy controls. These findings suggest that brain networks may be affected by different types of renal replacement therapy. (Source: Brain and Behavior)
Source: Brain and Behavior - June 24, 2020 Category: Neurology Authors: Bong Soo Park, Myungjun Seong, Junghae Ko, Si Hyung Park, Yang Wook Kim, Il Hwan Kim, Jin Han Park, Yoo Jin Lee, Seongho Park, Kang Min Park Tags: ORIGINAL RESEARCH Source Type: research

The maturation of the P1m component in response to voice from infancy to 3 years of age: A longitudinal study in young children
ConclusionOur data revealed the development of the auditory ‐evoked field in the left and right hemispheres from 0‐ to 3‐year‐old children. These results contribute to the elucidation of the development of brain functions in infants. (Source: Brain and Behavior)
Source: Brain and Behavior - June 23, 2020 Category: Neurology Authors: Yuko Yoshimura, Chiaki Hasegawa, Takashi Ikeda, Daisuke N. Saito, Hirotoshi Hiraishi, Tetsuya Takahashi, Hirokazu Kumazaki, Mitsuru Kikuchi Tags: ORIGINAL RESEARCH Source Type: research

Proteins of the Lectin Pathway of complement activation at the site of injury in subarachnoid hemorrhage compared with peripheral blood
ConclusionLectin pathway protein concentrations measured in peripheral blood do not always reflect changes at the site of injury. For some proteins, more information could be obtained in blood from the site of injury when investigating pathogenic mechanisms. (Source: Brain and Behavior)
Source: Brain and Behavior - June 21, 2020 Category: Neurology Authors: Thorkil Anker ‐Møller, Anne‐Mette Hvas, Niels Sunde, Steffen Thiel, Anne Troldborg Tags: ORIGINAL RESEARCH Source Type: research

The functional networks of a novel environment: Neural activity mapping in awake unrestrained rats using positron emission tomography
ConclusionThese results suggest that the novel cage is a stressful environment that inhibits activity in brain regions associated with exploratory behavior. Patterns of inhibition in the novel cage also support the proposed rat default mode network, indicating that animals are more cognitively engaged in this environment. Additionally, these data support the unique capability of combining FDG ‐PET with psychopharmacology experiments to examine novelty seeking and brain activation in the context of decision making, risk taking, and cognitive function more generally, along with response to environmental or stress challenge...
Source: Brain and Behavior - June 20, 2020 Category: Neurology Authors: Matthew McGregor, Kaleigh Richer, Mala Ananth, Panayotis K. Thanos Tags: ORIGINAL RESEARCH Source Type: research

Featured Cover
The cover image is based on the Original ArticleReduced uptake of [11C] ‐ABP688, a PET tracer for metabolic glutamate receptor 5 in hippocampus and amygdala in Alzheimer’s dementia by Valerie Treyer et al.,https://doi.org/10.1002/brb3.1632. (Source: Brain and Behavior)
Source: Brain and Behavior - June 18, 2020 Category: Neurology Tags: FEATURED COVER Source Type: research

Issue Information
Brain and Behavior, Volume 10, Issue 6, June 2020. (Source: Brain and Behavior)
Source: Brain and Behavior - June 18, 2020 Category: Neurology Tags: ISSUE INFORMATION Source Type: research

Functional network activity during errorless and trial ‐and‐error color‐name association learning
ConclusionsOur results suggest that within ‐DMN connectivity is important in T&E learning and that the learning benefit differences between EL and T&E approaches potentially relate to the functional integration strength between the DMN and FPN. (Source: Brain and Behavior)
Source: Brain and Behavior - June 18, 2020 Category: Neurology Authors: Madoka Yamashita, Tetsuya Shimokawa, Ferdinand Peper, Rumi Tanemura Tags: ORIGINAL RESEARCH Source Type: research

Altered functional connectivity of brain regions based on a meta ‐analysis in patients with T2DM: A resting‐state fMRI study
ConclusionsOur study showed a wide range of cerebellar –cerebral circuit abnormalities in patients with T2DM, which provides a new direction to investigate the neuropathological mechanisms of T2DM from the perspective of the cerebellum. (Source: Brain and Behavior)
Source: Brain and Behavior - June 18, 2020 Category: Neurology Authors: Dongsheng Zhang, Jie Gao, Xuejiao Yan, Min Tang, Xia Zhe, Miao Cheng, Weibo Chen, Xiaoling Zhang Tags: ORIGINAL RESEARCH Source Type: research

Neural substrates underlying progressive micrographia in Parkinson's disease
ConclusionsThese findings suggest that PM in free writing in PD patients is caused by the difficulty of monitoring whether the actual handwriting movements are desirable for maintaining letter size during self ‐paced handwriting. By contrast, PM in copying in PD patients is evoked by a lack of visual information about the personal handwriting and hand motions that are used as cues for maintaining letter sizes. (Source: Brain and Behavior)
Source: Brain and Behavior - June 18, 2020 Category: Neurology Authors: Shigenori Kanno, Mayumi Shinohara, Kasumi Kanno, Yukihiro Gomi, Makoto Uchiyama, Yoshiyuki Nishio, Toru Baba, Yoshiyuki Hosokai, Atsushi Takeda, Hiroshi Fukuda, Etsuro Mori, Kyoko Suzuki Tags: ORIGINAL RESEARCH Source Type: research

The effect of pentadecapeptide BPC 157 on hippocampal ischemia/reperfusion injuries in rats
ConclusionTogether, these findings suggest that these beneficial BPC 157 effects may provide a novel therapeutic solution for stroke. (Source: Brain and Behavior)
Source: Brain and Behavior - June 18, 2020 Category: Neurology Authors: Jak ša Vukojević, Borna Vrdoljak, Dominik Malekinušić, Marko Siroglavić, Marija Milavić, Danijela Kolenc, Alenka Boban Blagaić, Lovorka Batelja, Domagoj Drmić, Sven Seiverth, Predrag Sikirić Tags: ORIGINAL RESEARCH Source Type: research

Performance of healthy persons under pain in different cognitive load tasks: An event ‐related potential study on experimental pain individuals
ConclusionsInadequate early attention modulation, along with delayed peak energy for brain oscillation (delta and theta), could be accountable for a worse performance in cognitive tasks in the experimental pain group. Thus, cognitive load is a highly considerable factor. Overall, this study offers more insights into how healthy population works with cognitive tasks under pain neurologically. (Source: Brain and Behavior)
Source: Brain and Behavior - June 18, 2020 Category: Neurology Authors: Kangling Wang, Guiyuan Cai, Shimin Huang, Yuqi Li, Rongdong Li, Wen Wu Tags: ORIGINAL RESEARCH Source Type: research

Altered white matter integrity in patients with monocular blindness: A diffusion tensor imaging and tract ‐based spatial statistics study
ConclusionDTI and TBSS may be useful in examining abnormal spontaneous alterations in the WM of MB patients. The observed changes in FA and RD values may imply the larvaceous neurological mechanism involved in MB. (Source: Brain and Behavior)
Source: Brain and Behavior - June 17, 2020 Category: Neurology Authors: Yu ‐Xin Liu, Biao Li, Kang‐Rui Wu, Li‐Ying Tang, Qi Lin, Qing‐Hai Li, Qing Yuan, Wen‐Qing Shi, Rong‐Bin Liang, Qian‐Min Ge, Yi Shao Tags: ORIGINAL RESEARCH Source Type: research

Prognostic factors in children with head and neck rhabdomyosarcoma: A 12 ‐year retrospective study
ConclusionsImprovement in outcome was obtained with comprehensive treatment for head and neck RMS. Both chemotherapy efficacy and age of patients were prognostic factors for children with head and neck RMS, which provide some valuable information for further treatment. (Source: Brain and Behavior)
Source: Brain and Behavior - June 16, 2020 Category: Neurology Authors: Yi Zhang, Wei ‐Ling Zhang, Dong‐Sheng Huang, Yi‐Zhuo Wang, Hui‐Min Hu, Yan‐Yan Mei, Tian Zhi Tags: ORIGINAL RESEARCH Source Type: research

Effective connectivity during autobiographical memory search
ConclusionThese results suggest that prefrontal and posterior midline cortical regions together with the dlPFC largely coordinate the processes underlying AM search, setting up the conditions on which the angular gyrus and the hippocampus may act upon when the outcome of the search is successful. (Source: Brain and Behavior)
Source: Brain and Behavior - June 15, 2020 Category: Neurology Authors: Norberto Eiji Nawa, Hiroshi Ando Tags: ORIGINAL RESEARCH Source Type: research

Functional and cognitive capacity differ in dystonic motor subtypes when compared to choreatic and hypokinetic ‐rigid motor subtypes in Huntington's disease
The research confirmed that motoric phenotypes are relevant for functional and cognitive capacities in HD. Onsets in dystonic patients are similar to hypokinetic ‐rigids. Cognitive capacity is better in dystonic and choreatic than hypokinetic‐rigids patients. AbstractBackgroundMotor phenotypes in Huntington's disease vary manifold. Phenotype classification is essential to adapt treatment. The aim of this study was to classify a dystonic subtype closer.MethodsA total of 7,512 manifest ENROLL ‐HD participants were subdivided into mainly choreatic (N = 606), dystonic (N = 402), and hypokinetic‐rigi...
Source: Brain and Behavior - June 12, 2020 Category: Neurology Authors: Jannis Achenbach, Sarah Maria Hein, Carsten Saft Tags: ORIGINAL RESEARCH Source Type: research

Effects of oxiracetam combined with ginkgo biloba extract in the treatment of acute intracerebral hemorrhage: A clinical study
The combination of oxiracetam and ginkgo biloba extract in patients with acute intracerebral hemorrhage has potential in term of significantly improving the therapeutic effect and alleviating neurological deficit, reducing the absorption of hematoma and edema, and it is safe and beneficial to the rehabilitation of patients. AbstractPurposeThe present clinical study was conducted to investigate the effect of oxiracetam combined with ginkgo biloba extract in treating patients with acute intracerebral hemorrhage.MethodsNinety ‐eight patients with acute cerebral hemorrhage admitted to our hospital were divided into three gro...
Source: Brain and Behavior - June 12, 2020 Category: Neurology Authors: Xiu ‐Xiu Li, Shi‐Hui Liu, Su‐Jing Zhuang, Shi‐Feng Guo, Shou‐Liang Pang Tags: ORIGINAL RESEARCH Source Type: research

Blood pressure after follow ‐up in a stroke prevention clinic
ConclusionsTreatment of hypertension to individual targets after stroke is feasible. It may postpone recurrent stroke and death in stroke survivors. (Source: Brain and Behavior)
Source: Brain and Behavior - June 12, 2020 Category: Neurology Authors: Agnete Hviid Hornnes, Mai Bang Poulsen Tags: ORIGINAL RESEARCH Source Type: research

Altered gut bacterial –fungal interkingdom networks in patients with current depressive episode
ConclusionsOur findings suggest that both bacteria and fungi contribute to gut dysbiosis in patients with CDE. Future studies involving larger cohorts and metagenomic or metabolomic analyses may clarify the structure and potential roles and functions of the gut mycobiome and its impact on the development of CDE. (Source: Brain and Behavior)
Source: Brain and Behavior - June 12, 2020 Category: Neurology Authors: Hai ‐yin Jiang, Li‐ya Pan, Xue Zhang, Zhe Zhang, Yuan‐yue Zhou, Bing Ruan Tags: ORIGINAL RESEARCH Source Type: research

Expression of hypoxia ‐inducible factor 1α, glucose transporter 1, and hexokinase 2 in primary central nervous system lymphoma and the correlation with the biological behaviors
There was a hypoxic microenvironment, and HIF ‐1α was involved in the regulation of glycolysis pathway in PCNSL. GLUT1 might be a potential marker for shorter PFS in PCNSL. AbstractBackgroundIt has been indicated that abnormal glucose metabolism mediated by hypoxia ‐inducible factor 1α (HIF‐1α) played an essential role in the development of solid tumor. However, there were rare studies about the role of them in primary central nervous system lymphoma (PCNSL).ObjectiveTo investigate the protein levels of HIF ‐1α, glucose transporter 1 (GLUT1), and hexokinase 2 (HK2) in PCNSL and whether their...
Source: Brain and Behavior - June 12, 2020 Category: Neurology Authors: Na Shen, Yaming Wang, Xuefei Sun, Xueyan Bai, Jinglan He, Qu Cui, Jun Qian, Hong Zhu, Yuedan Chen, Ruixian Xing, Qing Liu, Yuchen Wu, Junhong Li, Wenyuan Lai, Shengjun Sun, Nan Ji, Yuanbo Liu Tags: ORIGINAL RESEARCH Source Type: research

Parkinson's disease or atypical parkinsonism? The importance of acoustic voice analysis in differential diagnosis of speech disorders
ConclusionAcoustic voice analysis is a very sensitive and noninvasive tool, provides objective information for the assessment of different speech components, has the specific potential to provide quantitative data essential for the improvement of the diagnostic process, and maybe a  useful instrument in the differential diagnosis of parkinsonian syndromes. (Source: Brain and Behavior)
Source: Brain and Behavior - June 11, 2020 Category: Neurology Authors: Renata Kowalska ‐Taczanowska, Andrzej Friedman, Dariusz Koziorowski Tags: DATA PAPER Source Type: research

Gepants for abortive treatment of migraine: A network meta ‐analysis
ConclusionGepants were effective for abortive treatment of migraine. The most effective treatment of gepants for migraine might be olcegepant which were administrated transvenously. And all of gepants were safe for migraine treatment with single dose. (Source: Brain and Behavior)
Source: Brain and Behavior - June 11, 2020 Category: Neurology Authors: Peiwei Hong, Tianlin Tan, Yao Liu, Jing Xiao Tags: ORIGINAL RESEARCH Source Type: research

Multi ‐voxel pattern analysis of amygdala functional connectivity at rest predicts variability in posttraumatic stress severity
ConclusionFindings demonstrate the utility of MVPA based on amygdala FC to predict individual severity of PTSD symptoms and that amygdala FC within a fear acquisition and regulation network contributed to accurate prediction. (Source: Brain and Behavior)
Source: Brain and Behavior - June 11, 2020 Category: Neurology Authors: Jacklynn M. Fitzgerald, Emily L. Belleau, Tara A. Miskovich, Walker S. Pedersen, Christine L. Larson Tags: ORIGINAL RESEARCH Source Type: research

Sex ‐dependent alterations of dopamine receptor and glucose transporter density in rat hypothalamus under long‐term clozapine and haloperidol medication
ConclusionClozapine sex ‐dependently affects the expression of D2R, Glut1, and Glut3. The upregulation of the glucose transporters indicates glucose deprivation in the endothelial cells and consequently in astrocytes and neurons. Increased hypothalamic lactate in females under clozapine points to enhanced glycolysis with a higher glucose demand to produce the required energy. Haloperidol did not change the expression of the glucose transporters and upregulated D2R only in males. (Source: Brain and Behavior)
Source: Brain and Behavior - June 11, 2020 Category: Neurology Authors: Marie ‐Luise Bouvier, Karin Fehsel, Andrea Schmitt, Eva Meisenzahl‐Lechner, Wolfgang Gaebel, Martina Wilmsdorff Tags: ORIGINAL RESEARCH Source Type: research

bFGF promotes neurological recovery from neonatal hypoxic –ischemic encephalopathy by IL‐1β signaling pathway‐mediated axon regeneration
ConclusionsWe showed that IL ‐1β‐mediated axon regeneration underlie the mechanism of bFGF for the treatment of HIBD in neonatal rats. Results from this study would provide insights and molecular basis for future therapeutics in treating HIBD. (Source: Brain and Behavior)
Source: Brain and Behavior - June 11, 2020 Category: Neurology Authors: Zheng Ma, Fang Wang, Lu ‐Lu Xue, Ying‐Jie Niu, Yue Hu, Zhang‐Yu Su, Jin Huang, Rui‐Ze Niu, Ting‐Hua Wang, Ying‐Chun Ba, Liu‐Lin Xiong, Xue Bai Tags: ORIGINAL RESEARCH Source Type: research

Left ventricular ejection fraction as an independent predictor of poor outcome in acute intracerebral hemorrhage
Left ventricular ejection fraction is an independent predictor of functional outcome and mortality at 3  months for acute intracerebral hemorrhage (ICH) patients. These findings could provide the evidence needed for prognosis prediction in acute ICH patients. AbstractIntroductionFew studies of the effect of cardiac abnormalities on acute intracerebral hemorrhage (ICH) outcomes have been published. We sought to determine whether the left ventricular ejection fraction (LVEF) is associated with the functional outcome and mortality of acute ICH patients.MethodsWe conducted a retrospective study on 364 acute ICH patients f...
Source: Brain and Behavior - June 9, 2020 Category: Neurology Authors: Guang Yang, Lu Wang, Jingxian Sun, Daming Zhang, Ruotian Zhang, Chao Yuan, Meixin Long, Yingqiang Zhong, Chunmei Li, Xiaoxiong Wang, Xin Chen, Qi Zhou, Bo Liu, Hongquan Jiang, Ailing Lian, Ilgiz Gareev, Lili Li, Shiguang Zhao Tags: ORIGINAL RESEARCH Source Type: research

Effectiveness of Natural Frequency Technology ® on cognition, sleep, and mood of adults with high perceived stress: A randomized, double‐blind, placebo‐controlled crossover study
NexQuest Natural Frequency Technology® (NFT), intended to enhance biological function using naturally occurring frequencies, may be a nonpharmacological intervention to improve stress and overall health. Using a randomized placebo ‐controlled design, we found that the NFT resulted in significant improvements in sleep quality, perceived stress, cognition (i.e., Reaction Time, Cognitive Flexibility, Processing Speed, Executive Functioning, and Neurocognition Index), food cravings, and mood for adults who report high perceived stress (N = 42). These findings indicate that NFT® may be a safe, natural altera...
Source: Brain and Behavior - June 8, 2020 Category: Neurology Authors: Heather A. Hausenblas, Stephanie Hooper, Ashlyn Knight, David Hooper Tags: ORIGINAL RESEARCH Source Type: research

“Seat of the soul”? The structure and function of the pineal gland in women with alleged spirit possession—Results of two experimental studies
ConclusionThe normal neuroimaging and stress reactivity findings in MG contrast with the abnormal results usually observed in subjects with psychotic and dissociative disorders. (Source: Brain and Behavior)
Source: Brain and Behavior - June 7, 2020 Category: Neurology Authors: Marco Aur élio Vinhosa Bastos, Paulo Roberto Haidamus de Oliveira Bastos, Loyná Euá Flores Paez, Edna Oliveira Souza, Danielle Bogo, Renata Trentin Perdomo, Renata Boschi Portella, Jorge Guilherme Okanobo Ozaki, Décio Iandoli, Giancarlo Lucch Tags: ORIGINAL RESEARCH Source Type: research

Trousseau syndrome with intrahepatic cholangiocarcinoma that could be removed radically after endovascular treatment: Report of a case
We report a case of Trousseau syndrome treated by radical resection after endovascular treatment.CaseA 59 ‐year‐old woman presented to our department reporting spontaneous dizziness and pain of the upper abdomen. Magnetic resolution imaging (MRI) showed shower embolization of Brain. Contrast‐enhanced computer tomography (CT) showed renal infarction and splenic infarction, and a tumor was observed in the retrohepatic area. On day 9, sudden right side joint prejudice, neglect of left half space, and left hemiplegia were observed. MRI revealed obstruction of the right middle cerebral artery (MCA) perfusion zone. On the ...
Source: Brain and Behavior - June 7, 2020 Category: Neurology Authors: Shuei Murahashi, Yosuke Takeuchi, Shintaro Hayashida, Yuki Ohya, Seigo Shindo, Tadashi Terasaki, Yukihiro Inomata, Yasuyuki Hara Tags: CASE REPORT Source Type: research

Altered activation in sensorimotor network after applying rTMS over the primary motor cortex at different frequencies
ConclusionOur findings suggested that activation alterations within sensorimotor network are dependent on the frequency of rTMS. Therefore, our findings contribute to understanding the effects of rTMS on brain activation in healthy individuals and ultimately may further help to suggest mechanisms of how rTMS could be employed as a therapeutic tool. (Source: Brain and Behavior)
Source: Brain and Behavior - June 7, 2020 Category: Neurology Authors: Xiaoyu Wang, Lingyu Li, Wei Wei, Tingting Zhu, Guo ‐Feng Huang, Xue Li, Hui‐Bin Ma, Yating Lv Tags: ORIGINAL RESEARCH Source Type: research

Dynamic visual cortical connectivity analysis based on functional magnetic resonance imaging
ConclusionTherefore, this study provides novel findings about dynamics of connectivity in human visual cortex from the perspective of functional and effective connectivity. (Source: Brain and Behavior)
Source: Brain and Behavior - June 7, 2020 Category: Neurology Authors: Le Zhao, Weiming Zeng, Yuhu Shi, Weifang Nie, Jiajun Yang Tags: ORIGINAL RESEARCH Source Type: research

Dissociated modulations of multivoxel activation patterns in the ventral and dorsal visual pathways by the temporal dynamics of stimuli
ConclusionsThese results are the first to show how temporal dynamics of stimulus change modulated multivoxel fMRI activation pattern change. And such temporal dynamic response function in different ROIs along the two visual pathways may shed lights on understanding functional relationship and organization of these ROIs. (Source: Brain and Behavior)
Source: Brain and Behavior - June 4, 2020 Category: Neurology Authors: Jiaxin Li, Bingbing Guo, Lin Cui, Hong Huang, Ming Meng Tags: ORIGINAL RESEARCH Source Type: research

Alzheimer's amyloid ‐β and tau protein accumulation is associated with decreased expression of the LDL receptor‐associated protein in human brain tissue
ConclusionReduction in RAP may contribute to the accumulation and aggregation of A β in the AD brain. (Source: Brain and Behavior)
Source: Brain and Behavior - June 2, 2020 Category: Neurology Authors: Claire E. Shepherd, Andrew J. Affleck, Anita Y. Bahar, Francine Carew ‐Jones, Gillian Gregory, David H. Small, Glenda M. Halliday Tags: ORIGINAL RESEARCH Source Type: research

Clinical relevance of serum omentin ‐1 levels as a biomarker of prognosis in patients with acute cerebral infarction
ConclusionsSerum omentin ‐1 levels at admission were significantly lower among patients with ACI. A higher plasma omentin‐1 level (>43.10  ng/ml) was negatively associated with poor functional prognosis 90 days after atherosclerotic ACI. Further studies are needed to investigate the pathophysiological mechanism of omentin‐1 in affecting attacks and prognosis of ACI as well as to confirm the value of plasma omentin‐1 level as a p otential biomarker. (Source: Brain and Behavior)
Source: Brain and Behavior - June 1, 2020 Category: Neurology Authors: Jingyi Yang, Yan Gao Tags: ORIGINAL RESEARCH Source Type: research

Limb ‐shaking transient ischemic attack with facial muscles involuntary twitch successfully treated with internal carotid artery stenting
ConclusionThis case report highlights the importance of accurate diagnosis and treatment, because treatment ‐related carotid artery occlusion can not only eliminate the attack, but also reduce the risk of future stroke. (Source: Brain and Behavior)
Source: Brain and Behavior - May 30, 2020 Category: Neurology Authors: Yuan ‐yuan Han, Dong Qi, Xiao‐Dong Chen, Chun‐Jie Song Tags: ORIGINAL RESEARCH Source Type: research

Hypoxic preconditioning enhances the differentiation of bone marrow stromal cells into mature oligodendrocytes via the mTOR/HIF ‐1α/VEGF pathway in traumatic brain injury
ConclusionThe results provided mechanistic evidences suggesting that HP ‐treated BMSCs promoted remyelination partly by modulating the pro‐survival mTOR/HIF‐1α/VEGF signaling pathway. (Source: Brain and Behavior)
Source: Brain and Behavior - May 30, 2020 Category: Neurology Authors: Xiaoyu Yuan, Qianqian Luo, Lihua Shen, Jin Chen, Deqiang Gan, Yechao Sun, Lingzhi Ding, Guohua Wang Tags: ORIGINAL RESEARCH Source Type: research