Photometric Evaluation of Adult Patients With Bilateral Cleft Lip and Palate Treated With Nasoalveolar Molding and Primary Columella Lengthening
CONCLUSIONS: Both NAM and primary rhinoplasty in patients with BCLP resulted in a near normal length of the columella and nasal projection until young adulthood. Nevertheless, width of all nasal features was significantly wider than the noncleft population and required secondary nasal correction in one-third of the sample.PMID:34132105 | DOI:10.1177/10556656211024069 (Source: The Cleft Palate-Craniofacial Journal)
Source: The Cleft Palate-Craniofacial Journal - June 16, 2021 Category: ENT & OMF Authors: Maria Costanza Meazzini Francesca Parravicini Vera Donati Roberto Brusati Federico Biglioli Luca Autelitano Source Type: research

Corrigendum to Estimating Craniofacial Growth Cessation: Comparison of Asymptote- and Rate-based Methods
Cleft Palate Craniofac J. 2021 Jun 16:10556656211024916. doi: 10.1177/10556656211024916. Online ahead of print.NO ABSTRACTPMID:34132107 | DOI:10.1177/10556656211024916 (Source: The Cleft Palate-Craniofacial Journal)
Source: The Cleft Palate-Craniofacial Journal - June 16, 2021 Category: ENT & OMF Source Type: research

Evaluation of Facial Appearance-Related Quality of Life in Young Japanese Patients With Cleft Lip and/or Palate
CONCLUSIONS: The instrument showed acceptable reliability, except for the coping domain. There were individual variations in QoL concerning the facial difference among Japanese youths with CL/P as measured by the YQOL-FD, suggesting the importance of individual evaluations. Perceptions were influenced by age, but not sex or cleft type.PMID:34132116 | DOI:10.1177/10556656211023243 (Source: The Cleft Palate-Craniofacial Journal)
Source: The Cleft Palate-Craniofacial Journal - June 16, 2021 Category: ENT & OMF Authors: Ayaka Oka Chihiro Tanikawa Yukako Isogai Kiyomi Mihara Takashi Yamashiro Source Type: research

Determination of Ethnic Variation in Infant Nasolabial Anthropometry Using 3D Photographs: Implications for Bilateral Cleft Lip Nasal Correction
Cleft Palate Craniofac J. 2021 Jun 16:10556656211024470. doi: 10.1177/10556656211024470. Online ahead of print.ABSTRACTOBJECTIVE: We aimed to assess significant ethnic variabilities in infants' nasolabial anthropometry to motivate variations in surgical correction of a synchronous bilateral cleft lip/nasal anomaly, specifically whether a long columella is a European feature, therefore accepting a short columella and/or delayed columellar lengthening suitable for reconstruction in ethnic patients.METHODS: Thirty-three infants without craniofacial pathology (10 African American [AA], 7 Hispanic [H], and 16 of European descen...
Source: The Cleft Palate-Craniofacial Journal - June 16, 2021 Category: ENT & OMF Authors: Diana S Jodeh Jacqueline M Ross Maria Leszczynska Fatima Qamar Rachel L Dawkins James J Cray S Alex Rottgers Source Type: research

The Tale of the Unrepaired Cleft-Retrospective Evaluation of Cases Encountered by an Indigenous Mission in a Northern Nigerian Community
CONCLUSION: We found a high proportion of patients with unrepaired cleft in our sample which may mirror happenings in other developing world centers. We advocate continued collaborations between indigenous missions and international funding agencies to further encourage continued repair of unrepaired cleft in developing centers.PMID:34128403 | DOI:10.1177/1055665620965437 (Source: The Cleft Palate-Craniofacial Journal)
Source: The Cleft Palate-Craniofacial Journal - June 15, 2021 Category: ENT & OMF Authors: Ifeoluwa Oketade Seidu A Bello John Adeoye Source Type: research

Personality and Cognitive-Emotional Variables in Spanish Children and Adolescents With and Without Cleft Lip and/or Palate
CONCLUSION: Children with CL/P showed strengths in self-efficacy typical of peers and less use of some maladaptive coping strategies; however, they also had higher levels of alexithymia and risk factors associated with the Big Five Model of personality. Strategies may be clinically useful that maximize areas of strength to support children with CL/P in expressing their emotions to reduce alexithymia, coping with of negative affect, and building assertiveness.PMID:34128404 | DOI:10.1177/1055665620965114 (Source: The Cleft Palate-Craniofacial Journal)
Source: The Cleft Palate-Craniofacial Journal - June 15, 2021 Category: ENT & OMF Authors: Ana Ruiz Guill én Mar ía José González Olmo Cecilia Pe ñacoba Puente Mart ín Romero Maroto Source Type: research

Morphometric Variations and Growth Analysis of the Side Face Profiles of Chinese Children
CONCLUSIONS: There is a significant difference in the side face profiles between adult males and females. Adult males have a higher brow (the 8th landmark) than females, and adult females have a more curved forehead. However, the side face profiles of boys and girls around 10 years of age are generally similar, which suggests that the significant difference in side face profiles between adult males and females may be formed after the age of 10. This study is of great significance for both orthodontists and pediatricians to use different norms for kids and adults and different norms for males and females for each of those a...
Source: The Cleft Palate-Craniofacial Journal - June 15, 2021 Category: ENT & OMF Authors: Haijun Li Huimin Chen Liming Liu Yujie Zhao Source Type: research

Feasibility of Social Media Recruitment for Orofacial Cleft Genetic Research
CONCLUSIONS: Unpaid social media advertising enabled the recruitment of a large cohort of participants in a short time (12 months). The resulting study population was limited in racial and ethnic diversity, suggesting that other recruitment strategies will be needed for studies seeking specific demographic or socioeconomic groups. Nonetheless, social media recruitment was efficient and effective for recruiting participants for a genetic study in comparison to traditional clinic-based modes of recruitment.PMID:34121473 | DOI:10.1177/10556656211024484 (Source: The Cleft Palate-Craniofacial Journal)
Source: The Cleft Palate-Craniofacial Journal - June 14, 2021 Category: ENT & OMF Authors: Grace Carlock Kelly Manning Elizabeth J Leslie Source Type: research

Feasibility of Social Media Recruitment for Orofacial Cleft Genetic Research
CONCLUSIONS: Unpaid social media advertising enabled the recruitment of a large cohort of participants in a short time (12 months). The resulting study population was limited in racial and ethnic diversity, suggesting that other recruitment strategies will be needed for studies seeking specific demographic or socioeconomic groups. Nonetheless, social media recruitment was efficient and effective for recruiting participants for a genetic study in comparison to traditional clinic-based modes of recruitment.PMID:34121473 | DOI:10.1177/10556656211024484 (Source: The Cleft Palate-Craniofacial Journal)
Source: The Cleft Palate-Craniofacial Journal - June 14, 2021 Category: ENT & OMF Authors: Grace Carlock Kelly Manning Elizabeth J Leslie Source Type: research

Pre-Hispanic Evidence of Cleft Lip and/or Palate in Mesoamerica
Cleft Palate Craniofac J. 2021 Jun 11:10556656211021701. doi: 10.1177/10556656211021701. Online ahead of print.ABSTRACTIn this letter, the authors present archeological evidence of the presence of cleft lip and/or palate (CLP) in pre-Hispanic Mesoamerica. During years 2016 and 2017, the authors visited 5 anthropology museums in Mexico, Guatemala, and El Salvador, in search for pre-Hispanic archeological evidence of CLP, and 16 anthropomorphic figurines with evidence of CLP were identified; 9 at the Anahuacalli Museum, 6 at the National Anthropology Museum of Mexico, and 1 at the National Anthropology Museum of El Salvador....
Source: The Cleft Palate-Craniofacial Journal - June 11, 2021 Category: ENT & OMF Authors: Ramon Manuel Aleman Maria Guadalupe Martinez Source Type: research

Pre-Hispanic Evidence of Cleft Lip and/or Palate in Mesoamerica
Cleft Palate Craniofac J. 2021 Jun 11:10556656211021701. doi: 10.1177/10556656211021701. Online ahead of print.ABSTRACTIn this letter, the authors present archeological evidence of the presence of cleft lip and/or palate (CLP) in pre-Hispanic Mesoamerica. During years 2016 and 2017, the authors visited 5 anthropology museums in Mexico, Guatemala, and El Salvador, in search for pre-Hispanic archeological evidence of CLP, and 16 anthropomorphic figurines with evidence of CLP were identified; 9 at the Anahuacalli Museum, 6 at the National Anthropology Museum of Mexico, and 1 at the National Anthropology Museum of El Salvador....
Source: The Cleft Palate-Craniofacial Journal - June 11, 2021 Category: ENT & OMF Authors: Ramon Manuel Aleman Maria Guadalupe Martinez Source Type: research

Pre-Hispanic Evidence of Cleft Lip and/or Palate in Mesoamerica
Cleft Palate Craniofac J. 2021 Jun 11:10556656211021701. doi: 10.1177/10556656211021701. Online ahead of print.ABSTRACTIn this letter, the authors present archeological evidence of the presence of cleft lip and/or palate (CLP) in pre-Hispanic Mesoamerica. During years 2016 and 2017, the authors visited 5 anthropology museums in Mexico, Guatemala, and El Salvador, in search for pre-Hispanic archeological evidence of CLP, and 16 anthropomorphic figurines with evidence of CLP were identified; 9 at the Anahuacalli Museum, 6 at the National Anthropology Museum of Mexico, and 1 at the National Anthropology Museum of El Salvador....
Source: The Cleft Palate-Craniofacial Journal - June 11, 2021 Category: ENT & OMF Authors: Ramon Manuel Aleman Maria Guadalupe Martinez Source Type: research

A Closer Look at Delayed Primary Cleft Surgery and Unrepaired Cleft Lip and/or Palate in 5 UK Cleft Centers
CONCLUSIONS: This large retrospective review highlights variations between centers regarding the timing of lip and palate surgery and details the reasons stated for delayed primary surgery. A small number of patients with an unrepaired cleft palate were identified. All had complex medical problems or comorbidities listed as a reason for the decision not to operate and 50% had a syndromic diagnosis. The number of patients receiving delayed surgery due to comorbidities, being underweight or prematurity, highlights the importance of the cleft specialist nurse and pediatrician within the cleft multidisciplinary team.PMID:34109...
Source: The Cleft Palate-Craniofacial Journal - June 10, 2021 Category: ENT & OMF Authors: Sophie Butterworth Clare Rivers Marnie Fullarton Colm Murphy Victoria Beale Jason Neil-Dwyer Simon Van Eeden Stephanie Van Eeden Peter D Hodgkinson Alistair Smyth David C Sainsbury Source Type: research

A Closer Look at Delayed Primary Cleft Surgery and Unrepaired Cleft Lip and/or Palate in 5 UK Cleft Centers
CONCLUSIONS: This large retrospective review highlights variations between centers regarding the timing of lip and palate surgery and details the reasons stated for delayed primary surgery. A small number of patients with an unrepaired cleft palate were identified. All had complex medical problems or comorbidities listed as a reason for the decision not to operate and 50% had a syndromic diagnosis. The number of patients receiving delayed surgery due to comorbidities, being underweight or prematurity, highlights the importance of the cleft specialist nurse and pediatrician within the cleft multidisciplinary team.PMID:34109...
Source: The Cleft Palate-Craniofacial Journal - June 10, 2021 Category: ENT & OMF Authors: Sophie Butterworth Clare Rivers Marnie Fullarton Colm Murphy Victoria Beale Jason Neil-Dwyer Simon Van Eeden Stephanie Van Eeden Peter D Hodgkinson Alistair Smyth David C Sainsbury Source Type: research

< em > ALX < /em > -Related Frontonasal Dysplasias: Clinical Characteristics and Surgical Management
CONCLUSIONS: This genetic classification system will help surgeon diagnose patients with FND with unique features and draw a roadmap for their treatment with a better surgical perspective.PMID:34098755 | DOI:10.1177/10556656211019621 (Source: The Cleft Palate-Craniofacial Journal)
Source: The Cleft Palate-Craniofacial Journal - June 8, 2021 Category: ENT & OMF Authors: Ibrahim Vargel Halil Ibrahim Canter Arda Kucukguven Asim Aydin Figen Ozgur Source Type: research

Mechanical Tension-Stress in Alveolar Cleft Repaired With Autogenous Bone in Canine Models
CONCLUSION: Rapid maxillary expansion after bone grafting had a positive effect on osteogenesis in a canine model of alveolar cleft.PMID:34098764 | DOI:10.1177/10556656211018950 (Source: The Cleft Palate-Craniofacial Journal)
Source: The Cleft Palate-Craniofacial Journal - June 8, 2021 Category: ENT & OMF Authors: Anqi Liu Jialiang Huang Source Type: research

< em > ALX < /em > -Related Frontonasal Dysplasias: Clinical Characteristics and Surgical Management
CONCLUSIONS: This genetic classification system will help surgeon diagnose patients with FND with unique features and draw a roadmap for their treatment with a better surgical perspective.PMID:34098755 | DOI:10.1177/10556656211019621 (Source: The Cleft Palate-Craniofacial Journal)
Source: The Cleft Palate-Craniofacial Journal - June 8, 2021 Category: ENT & OMF Authors: Ibrahim Vargel Halil Ibrahim Canter Arda Kucukguven Asim Aydin Figen Ozgur Source Type: research

Mechanical Tension-Stress in Alveolar Cleft Repaired With Autogenous Bone in Canine Models
CONCLUSION: Rapid maxillary expansion after bone grafting had a positive effect on osteogenesis in a canine model of alveolar cleft.PMID:34098764 | DOI:10.1177/10556656211018950 (Source: The Cleft Palate-Craniofacial Journal)
Source: The Cleft Palate-Craniofacial Journal - June 8, 2021 Category: ENT & OMF Authors: Anqi Liu Jialiang Huang Source Type: research

Speech Outcomes Following Orticochea Pharyngoplasty in Patients With History of Cleft Palate and Noncleft Velopharyngeal Dysfunction
Cleft Palate Craniofac J. 2021 Jun 4:10556656211010623. doi: 10.1177/10556656211010623. Online ahead of print.ABSTRACTOBJECTIVE: To report speech outcomes following Orticochea pharyngoplasty in 43 patients with cleft palate and noncleft velopharyngeal dysfunction.DESIGN: A retrospective surgical audit of patients undergoing Orticochea pharyngoplasty between 2004 and 2012, with speech as a primary outcome measure.SETTING: Patients known to a regional UK cleft center.METHODS: Forty-three patients underwent Orticochea pharyngoplasty by a single surgeon in a UK regional cleft center. Twenty-one patients had undergone a prior p...
Source: The Cleft Palate-Craniofacial Journal - June 4, 2021 Category: ENT & OMF Authors: Alison L Birch Zoe V Jordan Louisa M Ferguson Clare B Kelly John G Boorman Source Type: research

Exploring the Relationship Between Palatal Cleft Type and Width With the Use of Relieving Incisions in Primary Repair
Cleft Palate Craniofac J. 2021 Jun 4:10556656211019616. doi: 10.1177/10556656211019616. Online ahead of print.ABSTRACTOBJECTIVE: The mainstay of palatal repair in the United Kingdom is the intravelar veloplasty (IVVP). It is not always possible to align the oral mucosa in the midline to achieve tension-free repair. The addition of lateral relieving incisions may aid transposition of the oral mucosa to allow closure. The aim of this study was to explore cleft features that may predispose to a requirement for relieving incisions in order to allow palate closure.DESIGN: We performed a national multiinstitutional retrospective...
Source: The Cleft Palate-Craniofacial Journal - June 4, 2021 Category: ENT & OMF Authors: Alex Davies Amy Davies Yvonne Wren Scott Deacon Alistair R M Cobb Shaheel Chummun Source Type: research

Speech Outcomes Following Orticochea Pharyngoplasty in Patients With History of Cleft Palate and Noncleft Velopharyngeal Dysfunction
Cleft Palate Craniofac J. 2021 Jun 4:10556656211010623. doi: 10.1177/10556656211010623. Online ahead of print.ABSTRACTOBJECTIVE: To report speech outcomes following Orticochea pharyngoplasty in 43 patients with cleft palate and noncleft velopharyngeal dysfunction.DESIGN: A retrospective surgical audit of patients undergoing Orticochea pharyngoplasty between 2004 and 2012, with speech as a primary outcome measure.SETTING: Patients known to a regional UK cleft center.METHODS: Forty-three patients underwent Orticochea pharyngoplasty by a single surgeon in a UK regional cleft center. Twenty-one patients had undergone a prior p...
Source: The Cleft Palate-Craniofacial Journal - June 4, 2021 Category: ENT & OMF Authors: Alison L Birch Zoe V Jordan Louisa M Ferguson Clare B Kelly John G Boorman Source Type: research

Exploring the Relationship Between Palatal Cleft Type and Width With the Use of Relieving Incisions in Primary Repair
Cleft Palate Craniofac J. 2021 Jun 4:10556656211019616. doi: 10.1177/10556656211019616. Online ahead of print.ABSTRACTOBJECTIVE: The mainstay of palatal repair in the United Kingdom is the intravelar veloplasty (IVVP). It is not always possible to align the oral mucosa in the midline to achieve tension-free repair. The addition of lateral relieving incisions may aid transposition of the oral mucosa to allow closure. The aim of this study was to explore cleft features that may predispose to a requirement for relieving incisions in order to allow palate closure.DESIGN: We performed a national multiinstitutional retrospective...
Source: The Cleft Palate-Craniofacial Journal - June 4, 2021 Category: ENT & OMF Authors: Alex Davies Amy Davies Yvonne Wren Scott Deacon Alistair R M Cobb Shaheel Chummun Source Type: research

Speech Outcomes Following Orticochea Pharyngoplasty in Patients With History of Cleft Palate and Noncleft Velopharyngeal Dysfunction
Cleft Palate Craniofac J. 2021 Jun 4:10556656211010623. doi: 10.1177/10556656211010623. Online ahead of print.ABSTRACTOBJECTIVE: To report speech outcomes following Orticochea pharyngoplasty in 43 patients with cleft palate and noncleft velopharyngeal dysfunction.DESIGN: A retrospective surgical audit of patients undergoing Orticochea pharyngoplasty between 2004 and 2012, with speech as a primary outcome measure.SETTING: Patients known to a regional UK cleft center.METHODS: Forty-three patients underwent Orticochea pharyngoplasty by a single surgeon in a UK regional cleft center. Twenty-one patients had undergone a prior p...
Source: The Cleft Palate-Craniofacial Journal - June 4, 2021 Category: ENT & OMF Authors: Alison L Birch Zoe V Jordan Louisa M Ferguson Clare B Kelly John G Boorman Source Type: research

Exploring the Relationship Between Palatal Cleft Type and Width With the Use of Relieving Incisions in Primary Repair
Cleft Palate Craniofac J. 2021 Jun 4:10556656211019616. doi: 10.1177/10556656211019616. Online ahead of print.ABSTRACTOBJECTIVE: The mainstay of palatal repair in the United Kingdom is the intravelar veloplasty (IVVP). It is not always possible to align the oral mucosa in the midline to achieve tension-free repair. The addition of lateral relieving incisions may aid transposition of the oral mucosa to allow closure. The aim of this study was to explore cleft features that may predispose to a requirement for relieving incisions in order to allow palate closure.DESIGN: We performed a national multiinstitutional retrospective...
Source: The Cleft Palate-Craniofacial Journal - June 4, 2021 Category: ENT & OMF Authors: Alex Davies Amy Davies Yvonne Wren Scott Deacon Alistair R M Cobb Shaheel Chummun Source Type: research

Speech Outcomes Following Orticochea Pharyngoplasty in Patients With History of Cleft Palate and Noncleft Velopharyngeal Dysfunction
Cleft Palate Craniofac J. 2021 Jun 4:10556656211010623. doi: 10.1177/10556656211010623. Online ahead of print.ABSTRACTOBJECTIVE: To report speech outcomes following Orticochea pharyngoplasty in 43 patients with cleft palate and noncleft velopharyngeal dysfunction.DESIGN: A retrospective surgical audit of patients undergoing Orticochea pharyngoplasty between 2004 and 2012, with speech as a primary outcome measure.SETTING: Patients known to a regional UK cleft center.METHODS: Forty-three patients underwent Orticochea pharyngoplasty by a single surgeon in a UK regional cleft center. Twenty-one patients had undergone a prior p...
Source: The Cleft Palate-Craniofacial Journal - June 4, 2021 Category: ENT & OMF Authors: Alison L Birch Zoe V Jordan Louisa M Ferguson Clare B Kelly John G Boorman Source Type: research

Exploring the Relationship Between Palatal Cleft Type and Width With the Use of Relieving Incisions in Primary Repair
Cleft Palate Craniofac J. 2021 Jun 4:10556656211019616. doi: 10.1177/10556656211019616. Online ahead of print.ABSTRACTOBJECTIVE: The mainstay of palatal repair in the United Kingdom is the intravelar veloplasty (IVVP). It is not always possible to align the oral mucosa in the midline to achieve tension-free repair. The addition of lateral relieving incisions may aid transposition of the oral mucosa to allow closure. The aim of this study was to explore cleft features that may predispose to a requirement for relieving incisions in order to allow palate closure.DESIGN: We performed a national multiinstitutional retrospective...
Source: The Cleft Palate-Craniofacial Journal - June 4, 2021 Category: ENT & OMF Authors: Alex Davies Amy Davies Yvonne Wren Scott Deacon Alistair R M Cobb Shaheel Chummun Source Type: research

A Systematic Review of Mandibular Distraction Osteogenesis Versus Orthodontic Airway Plate for Airway Obstruction Treatment in Pierre Robin Sequence
CONCLUSIONS: Orthodontic airway plating may be considered for airway obstruction in PRS, as some airway-related and feeding-related outcomes appear similar with MDO, per existing evidence in the literature. However, since PRS severity differed between studies, OAP cannot be uniformly considered a replacement for MDO. Further research is required to more comprehensively assess these treatment modalities inclusive of metrics that allow for direct comparison.PMID:34075816 | DOI:10.1177/10556656211011886 (Source: The Cleft Palate-Craniofacial Journal)
Source: The Cleft Palate-Craniofacial Journal - June 2, 2021 Category: ENT & OMF Authors: Darren B Abbas Christopher Lavin Evan J Fahy HyeRan Choo Mai Thy Truong Karl C Bruckman Rohit K Khosla H Peter Lorenz Arash Momeni Derrick C Wan Source Type: research

A Systematic Review of Mandibular Distraction Osteogenesis Versus Orthodontic Airway Plate for Airway Obstruction Treatment in Pierre Robin Sequence
CONCLUSIONS: Orthodontic airway plating may be considered for airway obstruction in PRS, as some airway-related and feeding-related outcomes appear similar with MDO, per existing evidence in the literature. However, since PRS severity differed between studies, OAP cannot be uniformly considered a replacement for MDO. Further research is required to more comprehensively assess these treatment modalities inclusive of metrics that allow for direct comparison.PMID:34075816 | DOI:10.1177/10556656211011886 (Source: The Cleft Palate-Craniofacial Journal)
Source: The Cleft Palate-Craniofacial Journal - June 2, 2021 Category: ENT & OMF Authors: Darren B Abbas Christopher Lavin Evan J Fahy HyeRan Choo Mai Thy Truong Karl C Bruckman Rohit K Khosla H Peter Lorenz Arash Momeni Derrick C Wan Source Type: research

The International Family Study of Nonsyndromic Orofacial Clefts: Design and Methods
DISCUSSION: The International Family Study is the largest case set of NSOFCs with an associated biobank in LMICs currently assembled. The biobank, family, and case-control study now include samples from 8 LMICs where local health care infrastructure cannot address the surgical burden of cleft or investigate causal mechanisms. The International Family Study can be a source of information and may collaborate with local public health institutions regarding education and interventions to potentially prevent NSOFCs.PMID:34056937 | DOI:10.1177/10556656211018956 (Source: The Cleft Palate-Craniofacial Journal)
Source: The Cleft Palate-Craniofacial Journal - May 31, 2021 Category: ENT & OMF Authors: Allyn Auslander Roberta McKean-Cowdin Devin Feigelson Frederick Brindopke Melissa DiBona Kathy Magee Lili Arakaki Rijuta Kapoor Stephanie Ly David V Conti Sylvia Rakotoarison Fouzia Mahmoudi Albertina McGregor Melissa Giron Angela Rose Hernandez Thi-Hai-D Source Type: research

Cleft Lip and/or Palate and Associated Risks in Lower-Middle-Income Countries: A Systematic Review
CONCLUSION: Environmental risk factors are now being investigated more than biological risk factors in LMICs, aiding health care workers in the early identification of possible cumulative effects of risks in CL/P. Contextually relevant tools are recommended to promote early identification of at-risk infants.PMID:34056938 | DOI:10.1177/10556656211018952 (Source: The Cleft Palate-Craniofacial Journal)
Source: The Cleft Palate-Craniofacial Journal - May 31, 2021 Category: ENT & OMF Authors: Kayla Kruppa Esedra Kr üger Carlien Vorster Jeannie van der Linde Source Type: research

The International Family Study of Nonsyndromic Orofacial Clefts: Design and Methods
DISCUSSION: The International Family Study is the largest case set of NSOFCs with an associated biobank in LMICs currently assembled. The biobank, family, and case-control study now include samples from 8 LMICs where local health care infrastructure cannot address the surgical burden of cleft or investigate causal mechanisms. The International Family Study can be a source of information and may collaborate with local public health institutions regarding education and interventions to potentially prevent NSOFCs.PMID:34056937 | DOI:10.1177/10556656211018956 (Source: The Cleft Palate-Craniofacial Journal)
Source: The Cleft Palate-Craniofacial Journal - May 31, 2021 Category: ENT & OMF Authors: Allyn Auslander Roberta McKean-Cowdin Devin Feigelson Frederick Brindopke Melissa DiBona Kathy Magee Lili Arakaki Rijuta Kapoor Stephanie Ly David V Conti Sylvia Rakotoarison Fouzia Mahmoudi Albertina McGregor Melissa Giron Angela Rose Hernandez Thi-Hai-D Source Type: research

Cleft Lip and/or Palate and Associated Risks in Lower-Middle-Income Countries: A Systematic Review
CONCLUSION: Environmental risk factors are now being investigated more than biological risk factors in LMICs, aiding health care workers in the early identification of possible cumulative effects of risks in CL/P. Contextually relevant tools are recommended to promote early identification of at-risk infants.PMID:34056938 | DOI:10.1177/10556656211018952 (Source: The Cleft Palate-Craniofacial Journal)
Source: The Cleft Palate-Craniofacial Journal - May 31, 2021 Category: ENT & OMF Authors: Kayla Kruppa Esedra Kr üger Carlien Vorster Jeannie van der Linde Source Type: research

The International Family Study of Nonsyndromic Orofacial Clefts: Design and Methods
DISCUSSION: The International Family Study is the largest case set of NSOFCs with an associated biobank in LMICs currently assembled. The biobank, family, and case-control study now include samples from 8 LMICs where local health care infrastructure cannot address the surgical burden of cleft or investigate causal mechanisms. The International Family Study can be a source of information and may collaborate with local public health institutions regarding education and interventions to potentially prevent NSOFCs.PMID:34056937 | DOI:10.1177/10556656211018956 (Source: The Cleft Palate-Craniofacial Journal)
Source: The Cleft Palate-Craniofacial Journal - May 31, 2021 Category: ENT & OMF Authors: Allyn Auslander Roberta McKean-Cowdin Devin Feigelson Frederick Brindopke Melissa DiBona Kathy Magee Lili Arakaki Rijuta Kapoor Stephanie Ly David V Conti Sylvia Rakotoarison Fouzia Mahmoudi Albertina McGregor Melissa Giron Angela Rose Hernandez Thi-Hai-D Source Type: research

Cleft Lip and/or Palate and Associated Risks in Lower-Middle-Income Countries: A Systematic Review
CONCLUSION: Environmental risk factors are now being investigated more than biological risk factors in LMICs, aiding health care workers in the early identification of possible cumulative effects of risks in CL/P. Contextually relevant tools are recommended to promote early identification of at-risk infants.PMID:34056938 | DOI:10.1177/10556656211018952 (Source: The Cleft Palate-Craniofacial Journal)
Source: The Cleft Palate-Craniofacial Journal - May 31, 2021 Category: ENT & OMF Authors: Kayla Kruppa Esedra Kr üger Carlien Vorster Jeannie van der Linde Source Type: research

< em > Msx1 < /em > Heterozygosity in Mice Enhances Susceptibility to Phenytoin-Induced Hypoxic Stress Causing Cleft Palate
CONCLUSION: Our data suggest that cleft palate may occur because of the additive effects of Bmp4 downregulation as a result of Msx1 heterozygosity and decreased cell proliferation upon hypoxic stress. Human carriers of MSX1 mutations may have to take more precautions during pregnancy to avoid exposure to environmental risks.PMID:34047208 | DOI:10.1177/1055665620962690 (Source: The Cleft Palate-Craniofacial Journal)
Source: The Cleft Palate-Craniofacial Journal - May 28, 2021 Category: ENT & OMF Authors: Jinsil Park Mitsushiro Nakatomi Masaaki Sasaguri Manabu Habu Osamu Takahashi Daigo Yoshiga Kae Matsuyama Shinji Kataoka Takashi Toyono Yuji Seta Heiko Peters Kazuhiro Tominaga Source Type: research

Bone Growth Capacity of Human Umbilical Cord Mesenchymal Stem Cells and BMP-2 Seeded Into Hydroxyapatite/Chitosan/Gelatin Scaffold in Alveolar Cleft Defects: An Experimental Study in Goat
CONCLUSION: The HA/Cs/Gel+BMP-2+hUCMSCs were superior in enhancing new bone growth without donor site morbidity compared to ICABG. The presence of hUCMSCs in tissue-engineered alveolar bone graft (ABG), supported with paracrine activity of the resident stem cells, initiated earlier new bone repopulation, and completed faster bone regeneration. The HA/Cs/Gel scaffold seeded with UCMSCs+BMP-2 is a safe substitute of ICABG to close alveolar bone defects suitable for patients with cleft lip, alveolus, and palate.PMID:34047209 | DOI:10.1177/1055665620962360 (Source: The Cleft Palate-Craniofacial Journal)
Source: The Cleft Palate-Craniofacial Journal - May 28, 2021 Category: ENT & OMF Authors: Kristaninta Bangun Chaula L Sukasah Ismail H Dilogo Decky J Indrani Nurjati Chairani Siregar Jacub Pandelaki Diah Iskandriati Aria Kekalih Jessica Halim Source Type: research

The Prevalence of Nonsyndromic Oral Clefts in Twins Compared to Singletons: The Association With Birth Weight
CONCLUSION: Compared to singletons, twins did not have higher risk of nonsyndromic oral clefts. Infants with low birth weight were more prone to have nonsyndromic oral clefts.PMID:34047210 | DOI:10.1177/1055665620974566 (Source: The Cleft Palate-Craniofacial Journal)
Source: The Cleft Palate-Craniofacial Journal - May 28, 2021 Category: ENT & OMF Authors: Diluma Kariyawasam Shayesteh Jahanfar Source Type: research

Corrigendum to Velopharyngeal Muscle Morphology in Children With Unrepaired Submucous Cleft Palate: An Imaging Study
Cleft Palate Craniofac J. 2021 Jun;58(6):796-797. doi: 10.1177/10556656211013527.NO ABSTRACTPMID:34047211 | DOI:10.1177/10556656211013527 (Source: The Cleft Palate-Craniofacial Journal)
Source: The Cleft Palate-Craniofacial Journal - May 28, 2021 Category: ENT & OMF Source Type: research

< em > Msx1 < /em > Heterozygosity in Mice Enhances Susceptibility to Phenytoin-Induced Hypoxic Stress Causing Cleft Palate
CONCLUSION: Our data suggest that cleft palate may occur because of the additive effects of Bmp4 downregulation as a result of Msx1 heterozygosity and decreased cell proliferation upon hypoxic stress. Human carriers of MSX1 mutations may have to take more precautions during pregnancy to avoid exposure to environmental risks.PMID:34047208 | DOI:10.1177/1055665620962690 (Source: The Cleft Palate-Craniofacial Journal)
Source: The Cleft Palate-Craniofacial Journal - May 28, 2021 Category: ENT & OMF Authors: Jinsil Park Mitsushiro Nakatomi Masaaki Sasaguri Manabu Habu Osamu Takahashi Daigo Yoshiga Kae Matsuyama Shinji Kataoka Takashi Toyono Yuji Seta Heiko Peters Kazuhiro Tominaga Source Type: research

Bone Growth Capacity of Human Umbilical Cord Mesenchymal Stem Cells and BMP-2 Seeded Into Hydroxyapatite/Chitosan/Gelatin Scaffold in Alveolar Cleft Defects: An Experimental Study in Goat
CONCLUSION: The HA/Cs/Gel+BMP-2+hUCMSCs were superior in enhancing new bone growth without donor site morbidity compared to ICABG. The presence of hUCMSCs in tissue-engineered alveolar bone graft (ABG), supported with paracrine activity of the resident stem cells, initiated earlier new bone repopulation, and completed faster bone regeneration. The HA/Cs/Gel scaffold seeded with UCMSCs+BMP-2 is a safe substitute of ICABG to close alveolar bone defects suitable for patients with cleft lip, alveolus, and palate.PMID:34047209 | DOI:10.1177/1055665620962360 (Source: The Cleft Palate-Craniofacial Journal)
Source: The Cleft Palate-Craniofacial Journal - May 28, 2021 Category: ENT & OMF Authors: Kristaninta Bangun Chaula L Sukasah Ismail H Dilogo Decky J Indrani Nurjati Chairani Siregar Jacub Pandelaki Diah Iskandriati Aria Kekalih Jessica Halim Source Type: research

The Prevalence of Nonsyndromic Oral Clefts in Twins Compared to Singletons: The Association With Birth Weight
CONCLUSION: Compared to singletons, twins did not have higher risk of nonsyndromic oral clefts. Infants with low birth weight were more prone to have nonsyndromic oral clefts.PMID:34047210 | DOI:10.1177/1055665620974566 (Source: The Cleft Palate-Craniofacial Journal)
Source: The Cleft Palate-Craniofacial Journal - May 28, 2021 Category: ENT & OMF Authors: Diluma Kariyawasam Shayesteh Jahanfar Source Type: research

Corrigendum to Velopharyngeal Muscle Morphology in Children With Unrepaired Submucous Cleft Palate: An Imaging Study
Cleft Palate Craniofac J. 2021 Jun;58(6):796-797. doi: 10.1177/10556656211013527.NO ABSTRACTPMID:34047211 | DOI:10.1177/10556656211013527 (Source: The Cleft Palate-Craniofacial Journal)
Source: The Cleft Palate-Craniofacial Journal - May 28, 2021 Category: ENT & OMF Source Type: research

< em > Msx1 < /em > Heterozygosity in Mice Enhances Susceptibility to Phenytoin-Induced Hypoxic Stress Causing Cleft Palate
CONCLUSION: Our data suggest that cleft palate may occur because of the additive effects of Bmp4 downregulation as a result of Msx1 heterozygosity and decreased cell proliferation upon hypoxic stress. Human carriers of MSX1 mutations may have to take more precautions during pregnancy to avoid exposure to environmental risks.PMID:34047208 | DOI:10.1177/1055665620962690 (Source: The Cleft Palate-Craniofacial Journal)
Source: The Cleft Palate-Craniofacial Journal - May 28, 2021 Category: ENT & OMF Authors: Jinsil Park Mitsushiro Nakatomi Masaaki Sasaguri Manabu Habu Osamu Takahashi Daigo Yoshiga Kae Matsuyama Shinji Kataoka Takashi Toyono Yuji Seta Heiko Peters Kazuhiro Tominaga Source Type: research

Bone Growth Capacity of Human Umbilical Cord Mesenchymal Stem Cells and BMP-2 Seeded Into Hydroxyapatite/Chitosan/Gelatin Scaffold in Alveolar Cleft Defects: An Experimental Study in Goat
CONCLUSION: The HA/Cs/Gel+BMP-2+hUCMSCs were superior in enhancing new bone growth without donor site morbidity compared to ICABG. The presence of hUCMSCs in tissue-engineered alveolar bone graft (ABG), supported with paracrine activity of the resident stem cells, initiated earlier new bone repopulation, and completed faster bone regeneration. The HA/Cs/Gel scaffold seeded with UCMSCs+BMP-2 is a safe substitute of ICABG to close alveolar bone defects suitable for patients with cleft lip, alveolus, and palate.PMID:34047209 | DOI:10.1177/1055665620962360 (Source: The Cleft Palate-Craniofacial Journal)
Source: The Cleft Palate-Craniofacial Journal - May 28, 2021 Category: ENT & OMF Authors: Kristaninta Bangun Chaula L Sukasah Ismail H Dilogo Decky J Indrani Nurjati Chairani Siregar Jacub Pandelaki Diah Iskandriati Aria Kekalih Jessica Halim Source Type: research

The Prevalence of Nonsyndromic Oral Clefts in Twins Compared to Singletons: The Association With Birth Weight
CONCLUSION: Compared to singletons, twins did not have higher risk of nonsyndromic oral clefts. Infants with low birth weight were more prone to have nonsyndromic oral clefts.PMID:34047210 | DOI:10.1177/1055665620974566 (Source: The Cleft Palate-Craniofacial Journal)
Source: The Cleft Palate-Craniofacial Journal - May 28, 2021 Category: ENT & OMF Authors: Diluma Kariyawasam Shayesteh Jahanfar Source Type: research

Corrigendum to Velopharyngeal Muscle Morphology in Children With Unrepaired Submucous Cleft Palate: An Imaging Study
Cleft Palate Craniofac J. 2021 Jun;58(6):796-797. doi: 10.1177/10556656211013527.NO ABSTRACTPMID:34047211 | DOI:10.1177/10556656211013527 (Source: The Cleft Palate-Craniofacial Journal)
Source: The Cleft Palate-Craniofacial Journal - May 28, 2021 Category: ENT & OMF Source Type: research

Treatment of Cleft Lip and Palate in the Amazon Region in Brazil: Speech Results and Sociodemographic Aspects
CONCLUSIONS: Most individuals with repaired CLP from the Amazon region presented speech disorders, characterized by hypernasality and active errors. Patients living outside the state capital, of low socioeconomic level, underwent palatoplasty late and with presence of palatal fistula tended to have the worst speech outcomes.PMID:34032142 | DOI:10.1177/10556656211017791 (Source: The Cleft Palate-Craniofacial Journal)
Source: The Cleft Palate-Craniofacial Journal - May 25, 2021 Category: ENT & OMF Authors: Laryssa Lopes de Ara újo Nivaldo Alonso Ana Paula Fukushiro Source Type: research

Three-Dimensional Nasolabial Changes After Nasoalveolar Molding and Primary Lip/Nose Surgery in Infants With Bilateral Cleft Lip and Palate
CONCLUSIONS: There was a significant improvement in the nasolabial anatomy after NAM, and this was further enhanced after primary reconstructive surgery.PMID:34032145 | DOI:10.1177/10556656211012858 (Source: The Cleft Palate-Craniofacial Journal)
Source: The Cleft Palate-Craniofacial Journal - May 25, 2021 Category: ENT & OMF Authors: Laura Mancini Shayna Avinoam Barry H Grayson Roberto L Flores David A Staffenberg Pradip R Shetye Source Type: research

Treatment of Cleft Lip and Palate in the Amazon Region in Brazil: Speech Results and Sociodemographic Aspects
CONCLUSIONS: Most individuals with repaired CLP from the Amazon region presented speech disorders, characterized by hypernasality and active errors. Patients living outside the state capital, of low socioeconomic level, underwent palatoplasty late and with presence of palatal fistula tended to have the worst speech outcomes.PMID:34032142 | DOI:10.1177/10556656211017791 (Source: The Cleft Palate-Craniofacial Journal)
Source: The Cleft Palate-Craniofacial Journal - May 25, 2021 Category: ENT & OMF Authors: Laryssa Lopes de Ara újo Nivaldo Alonso Ana Paula Fukushiro Source Type: research

Three-Dimensional Nasolabial Changes After Nasoalveolar Molding and Primary Lip/Nose Surgery in Infants With Bilateral Cleft Lip and Palate
CONCLUSIONS: There was a significant improvement in the nasolabial anatomy after NAM, and this was further enhanced after primary reconstructive surgery.PMID:34032145 | DOI:10.1177/10556656211012858 (Source: The Cleft Palate-Craniofacial Journal)
Source: The Cleft Palate-Craniofacial Journal - May 25, 2021 Category: ENT & OMF Authors: Laura Mancini Shayna Avinoam Barry H Grayson Roberto L Flores David A Staffenberg Pradip R Shetye Source Type: research