The Use of Thiopurine Derivatives in the Treatment of Inflammatory Bowel Disease.
PMID: 31735159 [PubMed - in process] (Source: Reviews on Recent Clinical Trials)
Source: Reviews on Recent Clinical Trials - November 19, 2019 Category: Cancer & Oncology Authors: Puri BK Tags: Rev Recent Clin Trials Source Type: research

Potential Involvement of Impaired Venous Outflow from the Brain in Neurodegeneration: Lessons Learned from the Research on Chronic Cerebrospinal Venous Insufficiency.
Abstract About 10 years ago, the so-called chronic cerebrospinal venous insufficiency syndrome was discovered. This clinical entity, which is associated with extracranial venous abnormalities that impair venous outflow from the brain, was initially found exclusively in multiple sclerosis patients. Currently, we know that such venous lesions can also be revealed in other neurological pathologies, including Alzheimer's and Parkinson's diseases. Although direct causative role of chronic cerebrospinal venous insufficiency in these neurological diseases still remains elusive, in this paper, we suggest that perhaps an a...
Source: Reviews on Recent Clinical Trials - November 19, 2019 Category: Cancer & Oncology Authors: Simka M, Skuła M Tags: Rev Recent Clin Trials Source Type: research

Comparing Intradermal Sterile Water with Intravenous Morphine in Reducing Pain in Patients with Renal Colic: A Double-Blind Randomized Clinical Trial.
Abstract OBJECTIVE: The present study was conducted to investigate the effect of intradermal administration of sterile water compared to intravenous morphine on patients with renal colic. METHODS: This double-blind randomized clinical trial study was conducted in 2017 to compare the therapeutic effects of intradermal sterile water with those of intravenous morphine on patients with renal colic presenting to the emergency departments (ED) of Imam Khomeini and Golestan Hospitals in Ahvaz, Iran. The first group received 0.5 ml of intradermal sterile water, and the second group 0.1 mg/kg of intravenous morphine p...
Source: Reviews on Recent Clinical Trials - November 18, 2019 Category: Cancer & Oncology Authors: Mozaffari J, Verki MM, Tirandaz F, Mahjouri R Tags: Rev Recent Clin Trials Source Type: research

The Role of Hyperhomocysteinemia on the Development of Changes in the Lungs.
CONCLUSION: Mature animals of the experimental group are characterized by activation of inflammatory processes, oxidative stress, due to increased production of macrophages and, as a consequence, the launch of the humorous link of immunity, while in old rats were determined by fibrosis, disorders of the trophic and gas metabolism, as well as damage to the endothelium part of lungs. PMID: 31729946 [PubMed - as supplied by publisher] (Source: Reviews on Recent Clinical Trials)
Source: Reviews on Recent Clinical Trials - November 14, 2019 Category: Cancer & Oncology Authors: Maievskyi O, Samborska I, Kovalchuk O, Fagoonee S, Falalyeyeva T Tags: Rev Recent Clin Trials Source Type: research

Benign Intracranial Lesions - Radiotherapy: An Overview of Treatment Options, Indications and Therapeutic Results.
CONCLUSION: RT comprises an effective treatment modality of benign brain and intracranial lesions. By minimizing its ares with optimal use, RT projects as a potent tool against such diseases. PMID: 31713498 [PubMed - as supplied by publisher] (Source: Reviews on Recent Clinical Trials)
Source: Reviews on Recent Clinical Trials - November 10, 2019 Category: Cancer & Oncology Authors: Tzikoulis V, Gkantaifi A, Alongi F, Tsoukalas N, Saraireh HH, Charalampakis N, Tzikoulis G, Andreou E, Tsapakidis K, Kardamakis D, Tsanadis K, Kyrgias G, Tolia M Tags: Rev Recent Clin Trials Source Type: research

Efficacy and Safety of Non-Steroidal Anti-Androgens in Patients with Metastatic Prostate Cancer: Meta-Analysis of Randomized Controlled Trials.
Abstract BACKGROUND: Prostate cancer (PCa), the sixth primary cause of cancer death. Still, conflicts are present about the efficacy and safety of Non-steroidal anti-androgens (NSAA). Aim of this study was to assess the efficacy and safety of NSAAs versus any comparator for the treatment of advanced or metastatic PCa. METHODOLOGY: MEDLINE and the Cochrane Library were searched. References of included studies and clinicaltrials.gov were also searched for relevant studies. Only English language studies after 1990 were considered for review. Randomized controlled trials (RCTs) examining the efficacy and safety o...
Source: Reviews on Recent Clinical Trials - November 5, 2019 Category: Cancer & Oncology Authors: Rashid M, Ramesh M, Shamshavali K, Dang A, Patel H, Undela K Tags: Rev Recent Clin Trials Source Type: research

The Role of Biofilm In Central Venous Catheter Related Bloodstream Infections: Evidence Based Nursing And Review of The Literature.
CONCLUSION: The correct evidence-based nursing methods, based on the use of Guidelines, provides the opportunity to minimize the risks of infection through the implementation of a series of preventive measures both during the CVC positioning phase and in the subsequent phase, meaningly during device management which is performed by medical and nursing staff. PMID: 31656155 [PubMed - as supplied by publisher] (Source: Reviews on Recent Clinical Trials)
Source: Reviews on Recent Clinical Trials - October 18, 2019 Category: Cancer & Oncology Authors: Ielapi N, Nicoletti E, Lorè C, Guasticchi G, Avenoso T, Barbetta A, de Franciscis S, Andreucci M, Sapienza P, Serra R Tags: Rev Recent Clin Trials Source Type: research

An Industry Perspective on Risks and Mitigation strategies Associated with Post Conduct Phase of Clinical Trial.
CONCLUSION: Sponsors must act proactively to ensure a systematic approach to conduct various post conduct trial activities and the plans to mitigate the risks that could affect the quality and outcome of the clinical trial. Others/ Future perspective: A close coordination with all stakeholders for timely anticipation of risks and execution of mitigation strategies are required for successful CT outcome. PMID: 31622223 [PubMed - as supplied by publisher] (Source: Reviews on Recent Clinical Trials)
Source: Reviews on Recent Clinical Trials - October 15, 2019 Category: Cancer & Oncology Authors: Bhagat S, Kapatkar VK, Mane A, Pinto C, Parikh D, Mittal G, Jain R Tags: Rev Recent Clin Trials Source Type: research

ST-Elevation Myocardial Infarction due to Stent Underexpansion Managed with Coronary Lithoplasty.
CONCLUSION: Our case demonstrates the usefulness and safety of the lithoplasty system in the context of ST elevation myocardial infarction. PMID: 31560293 [PubMed - as supplied by publisher] (Source: Reviews on Recent Clinical Trials)
Source: Reviews on Recent Clinical Trials - September 27, 2019 Category: Cancer & Oncology Authors: Tripolino C, Tassone EJ, Morabito G, Grillo P, Missiroli B Tags: Rev Recent Clin Trials Source Type: research

Thrombosed External Haemorrhoids: A Clinician's Dilemma.
Abstract Haemorrhoids are vascular cushions that underlie the distal rectal mucosa and contribute approximately 15-20% of the resting anal pressure, ensuring complete closure of the anal canal. Apart of the wellknown chronic disturbances (prolapse, bleeding, pruritus) they can have an acute painful appearance that is a debilitating condition with an economic and social impact due to the time off work, high cost of treatments and reduction in quality of life. This complication, common in young adult patients with no gender differences and known as thrombosed haemorrhoids (TEH) can involve both the external and inte...
Source: Reviews on Recent Clinical Trials - September 27, 2019 Category: Cancer & Oncology Authors: Gallo G, Sammarco G, Trompetto M Tags: Rev Recent Clin Trials Source Type: research

Alcoholic Liver Disease: From Bench to Bedside.
Abstract PMID: 31512993 [PubMed - in process] (Source: Reviews on Recent Clinical Trials)
Source: Reviews on Recent Clinical Trials - September 13, 2019 Category: Cancer & Oncology Authors: Abenavoli L Tags: Rev Recent Clin Trials Source Type: research

Dexmedetomidine versus Midazolam-Fentanyl in procedural analgesia sedation for reduction of Anterior Shoulder Dislocation: A Randomized Clinical Trial.
CONCLUSIONS: The findings of this study, show that dexmedetomidine provides a higher level of analgesia than midazolam-fentanyl. Moreover, it was also shown that dexmedetomidine causes a quicker procedural sedation than midazolam-fentanyl. PMID: 31400271 [PubMed - as supplied by publisher] (Source: Reviews on Recent Clinical Trials)
Source: Reviews on Recent Clinical Trials - August 9, 2019 Category: Cancer & Oncology Authors: Masoumi K, Maleki SJ, Forouzan A, Delirrooyfard A, Hesam S Tags: Rev Recent Clin Trials Source Type: research

Patients driving the clinical trial designs - Democracy in clinical research.
CONCLUSION: Overall, the pharma domain is at the verge of putting the patient in the spotlight, and achieve a near-real democracy, where clinical research is the by the patient, for the patient and of the patient. PMID: 31393256 [PubMed - as supplied by publisher] (Source: Reviews on Recent Clinical Trials)
Source: Reviews on Recent Clinical Trials - August 8, 2019 Category: Cancer & Oncology Authors: Bhardwaj P, Kumar J, Yadav RK Tags: Rev Recent Clin Trials Source Type: research

Yoga protocol for cancer patients: A systematic exploration of psychophysiological benefits.
CONCLUSIONS: It's noteworthy that data, once analysed, showed a significant difference between pre-protocol and post protocol levels of anxiety and depression, but not for the perception of fatigue nor the quality of sleep. In accordance with the scientific literature, data from this study allow to highlight that practicing Yoga may promote change in levels of perceived anxiety and depression in patients in treatment for cancer, positively affecting their (QoL). PMID: 31362680 [PubMed - as supplied by publisher] (Source: Reviews on Recent Clinical Trials)
Source: Reviews on Recent Clinical Trials - July 29, 2019 Category: Cancer & Oncology Authors: Mirandola M, Sabogal Rueda MD, Andreis F, Meriggi F, Codignola C, Gadaldi E, Prochilo T, Libertini M, Di Biasi B, Abeni C, Noventa S, Rota L, Ogliosi C, Zaniboni A Tags: Rev Recent Clin Trials Source Type: research

What is the role of preoperative breathing exercises in reducing postoperative atelectasis after CABG?
CONCLUSION: preoperative breathing exercise doesn't reduce the pulmonary complications in patients undergoing CABG. PMID: 31291879 [PubMed - as supplied by publisher] (Source: Reviews on Recent Clinical Trials)
Source: Reviews on Recent Clinical Trials - July 10, 2019 Category: Cancer & Oncology Authors: Moradian ST, Heydari AA, Mahmoudi H Tags: Rev Recent Clin Trials Source Type: research

High Flow Through Nasal Cannula in Stable and Exacerbated Chronic Obstructive Pulmonary Disease Patients.
CONCLUSION: Though evidence of superiority still lacks and further studies are necessary, HFNC might play a role in the treatment of both stable and exacerbated COPD patients. PMID: 31291880 [PubMed - as supplied by publisher] (Source: Reviews on Recent Clinical Trials)
Source: Reviews on Recent Clinical Trials - July 10, 2019 Category: Cancer & Oncology Authors: Bruni A, Garofalo E, Cammarota G, Murabito P, Astuto M, Navalesi P, Luzza F, Abenavoli L, Longhini F Tags: Rev Recent Clin Trials Source Type: research

Comparison the analgesic effect of Intravenous Ketamine versus Intravenous Morphine in reducing pain of renal colic patients: Double-blind clinical trial study.
CONCLUSION: The findings suggest that the use of ketamine can produce a more rapid relief effect, and decrease the use of opioids which create various complications, including nausea and vomiting, in patients, especially patients with renal colic. PMID: 31284871 [PubMed - as supplied by publisher] (Source: Reviews on Recent Clinical Trials)
Source: Reviews on Recent Clinical Trials - July 5, 2019 Category: Cancer & Oncology Authors: Forouzan A, Masoumi K, Motamed H, Esfahani SRN, Delirrooyfard A Tags: Rev Recent Clin Trials Source Type: research

Research on the Development of Collaterals from Occluded Internal Mammary Arteries and Refractory Angina: Where are we in 2019?
ve; M Abstract PMID: 31210106 [PubMed - in process] (Source: Reviews on Recent Clinical Trials)
Source: Reviews on Recent Clinical Trials - June 20, 2019 Category: Cancer & Oncology Authors: Picichè M Tags: Rev Recent Clin Trials Source Type: research

Melatonin Improves Erythropoietin Hyporesponsiveness via Suppression of Inflammation.
Abstract BACKGROUND: Inadequate response to erythropoietin stimulating agents (ESA) despite of using relatively larger doses regimen represent a potential risk factor of cardiovascular (CV) related mortality in addition to health-care economic problems in anemic patients with chronic kidney disease (CKD). Erythropoietin (EPO) hyporesponsiveness related to inflammation has been increased progressively. Melatonin is well known as potent anti-inflammatory agent. Therefor the current study designed to evaluate whether melatonin could improve anemic patients response to EPO. METHOD: This single controlled clinical...
Source: Reviews on Recent Clinical Trials - May 28, 2019 Category: Cancer & Oncology Authors: Hameed EN, Al Tukmagi HFH, Allami HCA Tags: Rev Recent Clin Trials Source Type: research

Comparison of Sertraline with Rifampin in the treatment of Cholestatic pruritus: A randomized clinical trial.
CONCLUSION: There is no difference between sertraline and rifampin in pruritus improvement, but sertraline has less adverse effects on hepatobiliary enzyme levels, so it seems to be safer than rifampin. PMID: 30919782 [PubMed - as supplied by publisher] (Source: Reviews on Recent Clinical Trials)
Source: Reviews on Recent Clinical Trials - March 28, 2019 Category: Cancer & Oncology Authors: Ataei S, Kord L, Larki A, Yasrebifar F, Mehrpooya M, Seyedtabib M, Hasanzarrini M Tags: Rev Recent Clin Trials Source Type: research

Risk factors for Ischemic Heart Disease.
CONCLUSIONS: To prevent cardiovascular disease, it is important to minimize modifiable risk factors, like LDL cholesterol. PMID: 30919783 [PubMed - as supplied by publisher] (Source: Reviews on Recent Clinical Trials)
Source: Reviews on Recent Clinical Trials - March 28, 2019 Category: Cancer & Oncology Authors: Biscigli A, Pasceri V, Irini D, Varveri A, Speciale G Tags: Rev Recent Clin Trials Source Type: research

Domino Liver Transplantation: where are we now?
CONCLUSIONS: The results, the limits, the clinical challenges and the donor and recipient features of domino liver transplantation are discussed in this manuscript. PMID: 30894112 [PubMed - as supplied by publisher] (Source: Reviews on Recent Clinical Trials)
Source: Reviews on Recent Clinical Trials - March 20, 2019 Category: Cancer & Oncology Authors: Santopaolo F, Lenci I, Bosa A, Angelico M, Milana M, Baiocchi L Tags: Rev Recent Clin Trials Source Type: research

Clinical Operational Tolerance and Immunosuppression Minimization in Kidney Transplantation: Where Do We Stand?
CONCLUSION: . Multiple biomarkers and tolerance mechanisms suspected to be involved in renal transplantation have been investigated to understand their real role, with still no clear answers on the topic. Thus, the actual knowledge provided necessarily lead to more in-depth investigations, although many questions in the past have been answered, there are still many issues on renal tolerance that need to be addressed. PMID: 30868959 [PubMed - as supplied by publisher] (Source: Reviews on Recent Clinical Trials)
Source: Reviews on Recent Clinical Trials - March 13, 2019 Category: Cancer & Oncology Authors: Manzia TM, Gazia C, Baiocchi L, Lenci I, Milana M, Santopaolo F, Angelico R, Tisone G Tags: Rev Recent Clin Trials Source Type: research

Is the deductive falsification approach a better basis for clinical trial appraisal?
CONCLUSION: Trial grading following appraisal based on deductive falsification should be binary (0 = Invalid or 1 = Unclear) and single component scores should be multiplied. Appraisal criteria for the judgment of trial characteristics require a clear rationale, quantification of such rationale and empirical evidence concerning the effect of trial characteristics on trial results. PMID: 30868960 [PubMed - as supplied by publisher] (Source: Reviews on Recent Clinical Trials)
Source: Reviews on Recent Clinical Trials - March 13, 2019 Category: Cancer & Oncology Authors: Mickenautsch S Tags: Rev Recent Clin Trials Source Type: research

Real-World Efficacy and Safety of Pangenotypic Direct-Acting Antivirals Against Hepatitis C Virus Infection.
CONCLUSIONS: Pangenotypic DAAs result in very high rates of sustained virologic responses and are well tolerated. However, they are contraindicated in patients with decompensated cirrhosis or advanced chronic kidney disease who failed previous DDA-based treatment. Further research is required to customize treatment, to "unpackage" current DAA combinations and to develop generic drugs against HCV. PMID: 30848211 [PubMed - as supplied by publisher] (Source: Reviews on Recent Clinical Trials)
Source: Reviews on Recent Clinical Trials - March 6, 2019 Category: Cancer & Oncology Authors: Scotto R, Buonomo AR, Moriello NS, Maraolo AE, Zappulo E, Pinchera B, Gentile I, Borgia G Tags: Rev Recent Clin Trials Source Type: research

On-Pump Coronary Artery Bypass Graft: The State of the Art.
CONCLUSION: CABG still represents one of the most widespread major surgeries, with well-known benefits on symptoms and prognosis in patients with CAD. However, further studies and follow-up data are needed to validate these evidences. PMID: 30836924 [PubMed - as supplied by publisher] (Source: Reviews on Recent Clinical Trials)
Source: Reviews on Recent Clinical Trials - March 1, 2019 Category: Cancer & Oncology Authors: Cuminettido Sciatti G, Bonadei I, Vizzardi E, Sciatti E, Lorusso R Tags: Rev Recent Clin Trials Source Type: research

Psychosocial Risk Factors and Ischemic Heart Disease: A New Perspective.
CONCLUSIONS: For this reason, it is essential that professional psychological and psychotherapeutic support be rendered available to cardiology patients, as a means to enhance both the effectiveness and efficiency of care. PMID: 30836925 [PubMed - as supplied by publisher] (Source: Reviews on Recent Clinical Trials)
Source: Reviews on Recent Clinical Trials - March 1, 2019 Category: Cancer & Oncology Authors: Roncella A Tags: Rev Recent Clin Trials Source Type: research

Preface.
Abstract PMID: 30741130 [PubMed - in process] (Source: Reviews on Recent Clinical Trials)
Source: Reviews on Recent Clinical Trials - February 13, 2019 Category: Cancer & Oncology Authors: Abenavoli L Tags: Rev Recent Clin Trials Source Type: research

Clinical Trial Data Management Software: A Review of the Technical Features.
CONCLUSION: It seems that most of the systems used in the research centers were weak in terms of supporting the process of data management and managing clinical trial's workflow. Therefore, more attention should be paid to design a more complete, usable, and high quality data management system for clinical trials. More studies are suggested to identify the features of the successful systems used in clinical trials. PMID: 30734683 [PubMed - as supplied by publisher] (Source: Reviews on Recent Clinical Trials)
Source: Reviews on Recent Clinical Trials - February 7, 2019 Category: Cancer & Oncology Authors: Nourani A, Ayatollahi H, Dodaran MS Tags: Rev Recent Clin Trials Source Type: research

Mitral Stenosis in Pregnancy: A Comprehensive Review of a Challenging Cardio-Obstetric Clinical Entity.
CONCLUSION: Pregnancy and mitral stenosis remain a complex entity and a well-known trigger of maternal mortality during pregnancy and peri-partum period if not managed adequately. A good appreciation and recognition of the physiology of pregnancy and its impact on the pre-existing mitral stenosis and the presence of a specialized multidisciplinary team to handle such cases significantly decrease maternal and fetal mortality and morbidity. PMID: 30734684 [PubMed - as supplied by publisher] (Source: Reviews on Recent Clinical Trials)
Source: Reviews on Recent Clinical Trials - February 7, 2019 Category: Cancer & Oncology Authors: Abdelrahman S, Yousif N Tags: Rev Recent Clin Trials Source Type: research

Trials Comparing Percutaneous And Surgical Myocardial Revascularization: A Review.
CONCLUSION: CABG still remains the best strategy for the treatment of multiple vessel CAD due to improved results in term of survival and freedom from reintervention. Anyway, a systematic, multi-disciplinary approach to revascularization is the fundamental behaviour to be chased in order to effectively help the patients in overcoming its diseases. The creation of the "heart team" seems to be a good option for the correct treatment of patients suffering from stable and unstable CAD. PMID: 30706789 [PubMed - as supplied by publisher] (Source: Reviews on Recent Clinical Trials)
Source: Reviews on Recent Clinical Trials - January 31, 2019 Category: Cancer & Oncology Authors: De Palo M, Quagliara T, Dachille A, Carrozzo A, Giardinelli F, Mureddu S, Mastro F, Rotunno C, Paparella D Tags: Rev Recent Clin Trials Source Type: research

Off-pump Techniques of Surgical Myocardial Revascularization.
CONCLUSION: The debate about the advantages and disadvantages of on-pump versus off-pump coronary surgery seems to be an endless story. PMID: 30706790 [PubMed - as supplied by publisher] (Source: Reviews on Recent Clinical Trials)
Source: Reviews on Recent Clinical Trials - January 31, 2019 Category: Cancer & Oncology Authors: Dato GA, Picichè M Tags: Rev Recent Clin Trials Source Type: research

Laparoscopic Incisional and Ventral Hernia Repair with Absorbable Tacks in a Long Term Follow-up: A Retrospective Control Study.
Abstract BACKGROUND: Laparoscopic incisional and ventral hernia repair (LIVHR) is a safety and worldwide accepted procedure performed using also absorbable tacks. The aim of the study was to evaluate recurrence rate in a long term follow-up and whether the results of laparoscopic IVH repair in the elderly (≥65 years old) are different with respect to results obtained in younger patients. PATIENTS AND METHODS: One hundred and twenty-nine consecutive patients (74 women and 55 men, median age 67 years, range=30-87years) with ventral (N=42, 32.5%) or post incisional (N=87, 67.5%) hernia were enrolled in the st...
Source: Reviews on Recent Clinical Trials - January 31, 2019 Category: Cancer & Oncology Authors: Zanella S, Enrico L, Franceschi F, Buccelletti F, Potenza A, Zanoni A, Scudo G, Bonadies E, De Bellis M, Ricci F, Vassiliadis A Tags: Rev Recent Clin Trials Source Type: research

Effect of a Physical Activity Program on Serum Biochemical Parameters among Elderly Women.
Abstract BACKGROUND: The present study examined the efficacy of walking program on biochemical parameters among elderly women. METHODS: A total of one hundred elderly women participated in this randomized clinical trial study. The intervention group attended a 24-week walking exercise meeting five times per week. The control group continued with their routine activities. The subjects were assessed in Fasting blood glucose (FBS) and lipid profile before and after 12th and 24th weeks of the program. RESULTS: The mean age of the elderly participants in the study was 68.33 ± 4.55 years. The results of...
Source: Reviews on Recent Clinical Trials - January 31, 2019 Category: Cancer & Oncology Authors: Motallebi SA, Iranagh JA, Mohammadi F Tags: Rev Recent Clin Trials Source Type: research

Age-related Trends in Adults with Urinary Tract Infections Presenting to the Emergency Department: A 5-Year Experience.
Abstract INTRODUCTION: Urinary tract infections (UTIs) are among the most common bacterial infections, affecting 150 million people worldwide each year. Importantly, the incidence of UTI increases markedly with age. The increasing resistance to empirically prescribed antimicrobial agents complicates the management of this disease. This makes UTI an important issue in increasingly aging population and updated epidemiological investigation is advisable. To understand the epidemiological variation in UTI resistance patterns among differently aged populations, we conducted a retrospective study among patients presenti...
Source: Reviews on Recent Clinical Trials - December 26, 2018 Category: Cancer & Oncology Authors: Cardone S, Petruzziello C, Fiori B, Spanu T, D'Inzeo T, Franceschi F, Ojetti V Tags: Rev Recent Clin Trials Source Type: research

Advanced Non Small Cell Lung Cancer with activating Epidermal Growth Factor Receptor mutation: First line treatment and beyond.
CONCLUSION: To date, in the light of the data from the FLAURA study, osimertinib represents the best first line option in NSCLC patients with EGFR activating mutations; EGFR-TKI plus chemotherapy combination therapies, even though interesting, must still be considered investigational. PMID: 30520383 [PubMed - as supplied by publisher] (Source: Reviews on Recent Clinical Trials)
Source: Reviews on Recent Clinical Trials - December 5, 2018 Category: Cancer & Oncology Authors: Rocco D, Battiloro C, Gravara LD, Gridelli C Tags: Rev Recent Clin Trials Source Type: research

Malignant Pleural Effusion: Still A Long Way To Go.
CONCLUSIONS: Despite progress in therapeutic options, the prognosis remains severe, and the average survival is 4-9 months from the diagnosis of malignant pleural effusion. Moreover, mortality is higher for patients with malignant pleural effusion compared with those with metastatic cancer but no malignant pleural effusion. Therefore, the prognosis of these patients primarily depends on the underlying disease and the extension of the primary tumour. This review focuses on the most relevant updates in the management of malignant pleural effusion. PMID: 30514193 [PubMed - as supplied by publisher] (Source: Reviews on Re...
Source: Reviews on Recent Clinical Trials - December 3, 2018 Category: Cancer & Oncology Authors: Meriggi F Tags: Rev Recent Clin Trials Source Type: research

Unsolved issues in the treatment of spontaneous peritonitis in patients with cirrhosis: nosocomial versus community-acquired infections and the role of fungi.
CONCLUSION: Spontaneous bacterial peritonitis is one the most important complication in patients with cirrhosis. A proper empiric therapy is crucial to have a positive outcome. In this respect, a careful assessment of risk factors for multidrug-resistant pathogens is crucial. Likewise important, mostly in nosocomial cases, is not overlook the probability of a fungal ascitic infection, namely a spontaneous fungal peritonitis. PMID: 30514194 [PubMed - as supplied by publisher] (Source: Reviews on Recent Clinical Trials)
Source: Reviews on Recent Clinical Trials - December 3, 2018 Category: Cancer & Oncology Authors: Maraolo AE, Buonomo AR, Zappulo E, Scotto R, Pinchera B, Gentile I Tags: Rev Recent Clin Trials Source Type: research

Association Between Pulmonary Hypertension and Transcatheter Aortic Valve Replacement: Analysis of A Nationwide Inpatient Sample Database.
This study was done to review the association of pulmonary hypertension (PH) with Transcatheter Aortic Valve Replacement (TAVR) procedures done in the US for years 2010 to 2012. METHODS: We used Nationwide Inpatient Sample (NIS) data to extract data for patients who were hospitalized with a primary/secondary diagnosis of TAVR as specified by International Classification of Disease (ICD-9) codes 35.05 and 35.06. PH was identified with ICD-9 codes 416.0 and 416.8. Logistic regression models were used to analyze the association between PH and clinical outcomes of TAVR. RESULTS: A total of 8,824 weighted discharges w...
Source: Reviews on Recent Clinical Trials - November 19, 2018 Category: Cancer & Oncology Authors: Zoltowsk DM, Agrawal Y, Patel N, Sareen N, Kalavakunta JK, Gupta V, Halabi A Tags: Rev Recent Clin Trials Source Type: research

Hair Loss Prevention by a Scalp Cooling Device in Early Breast Cancer Patients: the Poliambulanza Preliminary Experience.
We report our preliminary experience with a scalp cooling device in reducing chemotherapy-induced alopecia and related distress in breast cancer patients undergoing adjuvant chemotherapy. METHODS: Hair loss grading and treatment tolerability were evaluated during chemotherapy every 21 days and 3 weeks after the last cycle of chemotherapy via Dean's scale by patients and operators and a comfort analogic scale by patients. We administered the Hospital Anxiety and Depression Scale questionnaire at the baseline and at the end of treatment to assess the distress related to chemotherapy-induced alopecia. RESULTS: Among...
Source: Reviews on Recent Clinical Trials - November 19, 2018 Category: Cancer & Oncology Authors: Prochilo T, Huscher A, Andreis F, Mirandola M, Zaina E, Pomentale B, Pedrali C, Zanotti L, Mutti S, Zaniboni A Tags: Rev Recent Clin Trials Source Type: research

Effect of Chondroitin Sulfate on Blood Serum Cytokine Profile during Carrageenan-induced Edema and Monoiodoacetate-induced Osteoarthritis in Rats.
Abstract Blood cytokines affect the development of inflammatory processes in both normal and pathological states. We have studied changes in the concentration of interleukins (ILs) -1β, IL-4, IL-10, IL-12B p40, transforming growth factor β (TGF β), tumor necrosis factor (TNF-α) in acute carrageenan-induced inflammation and degenerative-dystrophic changes of knee joint caused by monoiodoacetate-induced osteoarthritis (OA) in experimental models on rats. We also investigated the change in the cytokine profile during prophylactic and therapeutic administration of chondroitin sulfate to animals un...
Source: Reviews on Recent Clinical Trials - November 2, 2018 Category: Cancer & Oncology Authors: Korotkyi O, Vovk A, Blokhina O, Dvorshchenko K, Falalyeyeva T, Abenavoli L, Ostapchenko L Tags: Rev Recent Clin Trials Source Type: research

Rosmarinic Acid as Potential Anti-Inflammatory Agent.
Abstract Rosmarinus officinalis L. (Lamiaceae), popularly known as rosemary, is used for food flavoring, and in folk medicine, as an antispasmodic, analgesic, anti-rheumatic, diuretic, and antiepileptic agent. Rosemary is an herb widely used in folk medicine, cosmetics, and phytotherapy and for flavoring of food products. Studies have focused on various biological activities of the secondary metabolites of this plant, such as rosmarinic acid, which have powerful antioxidant, hepato-protective, antimicrobial, anti-nociceptive, and anti-inflammatory properties. PMID: 30328397 [PubMed - in process] (Source: Revi...
Source: Reviews on Recent Clinical Trials - October 19, 2018 Category: Cancer & Oncology Authors: Colica C, Di Renzo L, Aiello V, De Lorenzo A, Abenavoli L Tags: Rev Recent Clin Trials Source Type: research

A Review of the Process of Clinical Trials Data Management in Clinical Data Management Systems: A Review.
CONCLUSION: Seemingly, in relation with the performance of data management systems, not sufficient attention was paid to automation all dimensions of the clinical data management process. However, these systems could take positive steps towards changing the manual processes of clinical data management to electronic processes. PMID: 30251611 [PubMed - as supplied by publisher] (Source: Reviews on Recent Clinical Trials)
Source: Reviews on Recent Clinical Trials - September 24, 2018 Category: Cancer & Oncology Authors: Nourani A, Ayatollahi H, Dodaran MS Tags: Rev Recent Clin Trials Source Type: research

Effect of Kangaroo Mother Care on successful breastfeeding: A systematic review and Meta-Analysis of randomised controlled trials.
Abstract BACKGROUND & AIMS: Evaluating the effect of Kangaroo Mother Care (KMC) on breastfeeding success shows conflicting results. Regarding the importance of breastfeeding and uncertainties about its effect, this study intended to conduct a systematic review and meta-analysis of randomised controlled trials on the effect of KMC on success of breastfeeding. METHODS: In this systematic review and meta-analysis study, required data were collected by searching the following key words: breastfeeding, Breast-Feeding, "skin-to-skin", "Kangaroo Mother Care", randomized clinical trial. The fo...
Source: Reviews on Recent Clinical Trials - September 24, 2018 Category: Cancer & Oncology Authors: Ghojazadeh M, Hajebrahimi S, Pournaghi-Azar F, Mohseni M, Derakhshani N, Azami-Aghdash S Tags: Rev Recent Clin Trials Source Type: research

A Concise History of Thiopurines for Inflammatory Bowel Disease: from Anecdotal Reporting to Treat-to-Target Algorithms.
CONCLUSION: In UC thiopurines may be recognized to effect a treat-to-target strategy, joining the modern algorithms of rheumatologic disorders. PMID: 30198438 [PubMed - as supplied by publisher] (Source: Reviews on Recent Clinical Trials)
Source: Reviews on Recent Clinical Trials - September 10, 2018 Category: Cancer & Oncology Authors: Actis GC, Pellicano R, Ribaldone DG Tags: Rev Recent Clin Trials Source Type: research

The Management of Newly Diagnosed HIV in a Sudanese Refugee in Canada: Commentary and Review of Literature.
CONCLUSIONS: Assessment of current HIV programs is necessary to recognize and resolve gaps in the system. Focusing on programs which increase both risk reduction behaviors in refugee camps and integration of refugees in a new healthcare system can facilitate an easier transition for patients and aid in the quest for global 90-90-90 targets for HIV. PMID: 30179141 [PubMed - as supplied by publisher] (Source: Reviews on Recent Clinical Trials)
Source: Reviews on Recent Clinical Trials - September 3, 2018 Category: Cancer & Oncology Authors: Sidhu A, Kakkar R, Alenezi O Tags: Rev Recent Clin Trials Source Type: research

Gender differences in types, frequency, clinical manifestations and atherosclerotic burden of coronary artery anomalies.
CONCLUSION: Both genders have similar impact on the overall prevalence, clinical manifestations and atherosclerotic burden of CAAs. Anomaly of RCA originating from LCX occurred more frequently in males than females. PMID: 30124159 [PubMed - as supplied by publisher] (Source: Reviews on Recent Clinical Trials)
Source: Reviews on Recent Clinical Trials - August 19, 2018 Category: Cancer & Oncology Authors: Yousif N, Shahin M, Luscher TF, Obeid S Tags: Rev Recent Clin Trials Source Type: research

Prevention of Infection in Adults Receiving Intravenous Antibiotic Treatment via Indwelling Central Venous Access Devices.
Conclusion It is suggested that oral colestyramine supplementation may help prevent such infection through its ability to bind C. difficile toxin A (TcdA) and C. difficile toxin B (TcdB); these toxins are able to gain entry into host cells through receptor-mediated endocytosis, while anti-toxin antibody responses to TcdA and TcdB have been shown to induce protection against C. difficile infection sequelae. PMID: 30117400 [PubMed - as supplied by publisher] (Source: Reviews on Recent Clinical Trials)
Source: Reviews on Recent Clinical Trials - August 17, 2018 Category: Cancer & Oncology Authors: Puri BK, Derham A, Monro JA Tags: Rev Recent Clin Trials Source Type: research

Cardiometabolic Comorbidities in Autoimmune Rheumatic Diseases: From Pathogenesis to Treatment.
PMID: 30084330 [PubMed - in process] (Source: Reviews on Recent Clinical Trials)
Source: Reviews on Recent Clinical Trials - August 10, 2018 Category: Cancer & Oncology Authors: Ursini F, Ruscitti P Tags: Rev Recent Clin Trials Source Type: research

Successful use of Aliskiren in a case of IgA- mesangial glomerulonephritis unresponsive to conventional therapies.
Conclusions Aliskiren might represent a valid and safe therapeutic option in IgA GMN, although further investigations would be needed to confirm this conclusion. PMID: 30047335 [PubMed - as supplied by publisher] (Source: Reviews on Recent Clinical Trials)
Source: Reviews on Recent Clinical Trials - July 25, 2018 Category: Cancer & Oncology Authors: Simeoni M, Nicotera R, Pelagi E, Libri E, Comi N, Fuiano G Tags: Rev Recent Clin Trials Source Type: research