Evaluation of Urolithin A Efficacy in Heart Failure Patients with Reduced Ejection Fraction: A Randomized, Double-blind, Crossover, Placebo-controlled Clinical Trial
CONCLUSION: The results of the present study do not support any positive effect of UA supplementation in improving echocardiographic and biochemical indices of HFrEF. Further studies with higher doses of UA and longer supplementation duration are encouraged to be conducted.CLINICAL TRIAL REGISTRATION NUMBER: IRCT20210216050375N1.PMID:38415449 | DOI:10.2174/0115748871279354240209101604 (Source: Reviews on Recent Clinical Trials)
Source: Reviews on Recent Clinical Trials - February 28, 2024 Category: Cancer & Oncology Authors: Tannaz Jamialahmadi Maede Hasanpour Farveh Vakilian Peter E Penson Milad Iranshahy Amirhossein Sahebkar Source Type: research
Evaluation of Urolithin A Efficacy in Heart Failure Patients with Reduced Ejection Fraction: A Randomized, Double-blind, Crossover, Placebo-controlled Clinical Trial
CONCLUSION: The results of the present study do not support any positive effect of UA supplementation in improving echocardiographic and biochemical indices of HFrEF. Further studies with higher doses of UA and longer supplementation duration are encouraged to be conducted.CLINICAL TRIAL REGISTRATION NUMBER: IRCT20210216050375N1.PMID:38415449 | DOI:10.2174/0115748871279354240209101604 (Source: Reviews on Recent Clinical Trials)
Source: Reviews on Recent Clinical Trials - February 28, 2024 Category: Cancer & Oncology Authors: Tannaz Jamialahmadi Maede Hasanpour Farveh Vakilian Peter E Penson Milad Iranshahy Amirhossein Sahebkar Source Type: research
Evaluation of Urolithin A Efficacy in Heart Failure Patients with Reduced Ejection Fraction: A Randomized, Double-blind, Crossover, Placebo-controlled Clinical Trial
CONCLUSION: The results of the present study do not support any positive effect of UA supplementation in improving echocardiographic and biochemical indices of HFrEF. Further studies with higher doses of UA and longer supplementation duration are encouraged to be conducted.CLINICAL TRIAL REGISTRATION NUMBER: IRCT20210216050375N1.PMID:38415449 | DOI:10.2174/0115748871279354240209101604 (Source: Reviews on Recent Clinical Trials)
Source: Reviews on Recent Clinical Trials - February 28, 2024 Category: Cancer & Oncology Authors: Tannaz Jamialahmadi Maede Hasanpour Farveh Vakilian Peter E Penson Milad Iranshahy Amirhossein Sahebkar Source Type: research
Evaluation of Urolithin A Efficacy in Heart Failure Patients with Reduced Ejection Fraction: A Randomized, Double-blind, Crossover, Placebo-controlled Clinical Trial
CONCLUSION: The results of the present study do not support any positive effect of UA supplementation in improving echocardiographic and biochemical indices of HFrEF. Further studies with higher doses of UA and longer supplementation duration are encouraged to be conducted.CLINICAL TRIAL REGISTRATION NUMBER: IRCT20210216050375N1.PMID:38415449 | DOI:10.2174/0115748871279354240209101604 (Source: Reviews on Recent Clinical Trials)
Source: Reviews on Recent Clinical Trials - February 28, 2024 Category: Cancer & Oncology Authors: Tannaz Jamialahmadi Maede Hasanpour Farveh Vakilian Peter E Penson Milad Iranshahy Amirhossein Sahebkar Source Type: research
Evaluation of Urolithin A Efficacy in Heart Failure Patients with Reduced Ejection Fraction: A Randomized, Double-blind, Crossover, Placebo-controlled Clinical Trial
CONCLUSION: The results of the present study do not support any positive effect of UA supplementation in improving echocardiographic and biochemical indices of HFrEF. Further studies with higher doses of UA and longer supplementation duration are encouraged to be conducted.CLINICAL TRIAL REGISTRATION NUMBER: IRCT20210216050375N1.PMID:38415449 | DOI:10.2174/0115748871279354240209101604 (Source: Reviews on Recent Clinical Trials)
Source: Reviews on Recent Clinical Trials - February 28, 2024 Category: Cancer & Oncology Authors: Tannaz Jamialahmadi Maede Hasanpour Farveh Vakilian Peter E Penson Milad Iranshahy Amirhossein Sahebkar Source Type: research
Evaluation of Urolithin A Efficacy in Heart Failure Patients with Reduced Ejection Fraction: A Randomized, Double-blind, Crossover, Placebo-controlled Clinical Trial
CONCLUSION: The results of the present study do not support any positive effect of UA supplementation in improving echocardiographic and biochemical indices of HFrEF. Further studies with higher doses of UA and longer supplementation duration are encouraged to be conducted.CLINICAL TRIAL REGISTRATION NUMBER: IRCT20210216050375N1.PMID:38415449 | DOI:10.2174/0115748871279354240209101604 (Source: Reviews on Recent Clinical Trials)
Source: Reviews on Recent Clinical Trials - February 28, 2024 Category: Cancer & Oncology Authors: Tannaz Jamialahmadi Maede Hasanpour Farveh Vakilian Peter E Penson Milad Iranshahy Amirhossein Sahebkar Source Type: research
Evaluation of Urolithin A Efficacy in Heart Failure Patients with Reduced Ejection Fraction: A Randomized, Double-blind, Crossover, Placebo-controlled Clinical Trial
CONCLUSION: The results of the present study do not support any positive effect of UA supplementation in improving echocardiographic and biochemical indices of HFrEF. Further studies with higher doses of UA and longer supplementation duration are encouraged to be conducted.CLINICAL TRIAL REGISTRATION NUMBER: IRCT20210216050375N1.PMID:38415449 | DOI:10.2174/0115748871279354240209101604 (Source: Reviews on Recent Clinical Trials)
Source: Reviews on Recent Clinical Trials - February 28, 2024 Category: Cancer & Oncology Authors: Tannaz Jamialahmadi Maede Hasanpour Farveh Vakilian Peter E Penson Milad Iranshahy Amirhossein Sahebkar Source Type: research
Evaluation of Urolithin A Efficacy in Heart Failure Patients with Reduced Ejection Fraction: A Randomized, Double-blind, Crossover, Placebo-controlled Clinical Trial
CONCLUSION: The results of the present study do not support any positive effect of UA supplementation in improving echocardiographic and biochemical indices of HFrEF. Further studies with higher doses of UA and longer supplementation duration are encouraged to be conducted.CLINICAL TRIAL REGISTRATION NUMBER: IRCT20210216050375N1.PMID:38415449 | DOI:10.2174/0115748871279354240209101604 (Source: Reviews on Recent Clinical Trials)
Source: Reviews on Recent Clinical Trials - February 28, 2024 Category: Cancer & Oncology Authors: Tannaz Jamialahmadi Maede Hasanpour Farveh Vakilian Peter E Penson Milad Iranshahy Amirhossein Sahebkar Source Type: research
Characterization of Intrinsically Disordered Proteins in Healthy and Diseased States by Nuclear Magnetic Resonance
Rev Recent Clin Trials. 2024 Feb 21. doi: 10.2174/0115748871271420240213064251. Online ahead of print.ABSTRACTIntrinsically Disordered Proteins (IDPs) are active in different cellular procedures like ordered assembly of chromatin and ribosomes, interaction with membrane, protein, and ligand binding, molecular recognition, binding, and transportation via nuclear pores, microfilaments and microtubules process and disassembly, protein functions, RNA chaperone, and nucleic acid binding, modulation of the central dogma, cell cycle, and other cellular activities, post-translational qualification and substitute splicing, and flex...
Source: Reviews on Recent Clinical Trials - February 27, 2024 Category: Cancer & Oncology Authors: Mohamad Hesam Shahrajabian Wenli Sun Source Type: research
The Power of the Underutilized and Neglected Medicinal Plants and Herbs of the Middle East
Rev Recent Clin Trials. 2024 Feb 21. doi: 10.2174/0115748871276544240212105612. Online ahead of print.ABSTRACTThe Middle east and North Africa harbour many native species with pharmaceutical and nutraceutical potential. Since the beginning of history, food and herbal medicinal plants have been an essential part of human lives and the traditional Middle Eastern healthcare system. The notable medicinal plants that have been mentioned in the Bible, which are common in West Asia and some regions of North Africa, are Aloe vera, anise, balm, cassia, cinnamon, cumin, flax, and fig. Chemical components of Aloe vera are aloin, sina...
Source: Reviews on Recent Clinical Trials - February 27, 2024 Category: Cancer & Oncology Authors: Mohamad Hesam Shahrajabian Wenli Sun Source Type: research
Characterization of Intrinsically Disordered Proteins in Healthy and Diseased States by Nuclear Magnetic Resonance
Rev Recent Clin Trials. 2024 Feb 21. doi: 10.2174/0115748871271420240213064251. Online ahead of print.ABSTRACTIntrinsically Disordered Proteins (IDPs) are active in different cellular procedures like ordered assembly of chromatin and ribosomes, interaction with membrane, protein, and ligand binding, molecular recognition, binding, and transportation via nuclear pores, microfilaments and microtubules process and disassembly, protein functions, RNA chaperone, and nucleic acid binding, modulation of the central dogma, cell cycle, and other cellular activities, post-translational qualification and substitute splicing, and flex...
Source: Reviews on Recent Clinical Trials - February 27, 2024 Category: Cancer & Oncology Authors: Mohamad Hesam Shahrajabian Wenli Sun Source Type: research
The Power of the Underutilized and Neglected Medicinal Plants and Herbs of the Middle East
Rev Recent Clin Trials. 2024 Feb 21. doi: 10.2174/0115748871276544240212105612. Online ahead of print.ABSTRACTThe Middle east and North Africa harbour many native species with pharmaceutical and nutraceutical potential. Since the beginning of history, food and herbal medicinal plants have been an essential part of human lives and the traditional Middle Eastern healthcare system. The notable medicinal plants that have been mentioned in the Bible, which are common in West Asia and some regions of North Africa, are Aloe vera, anise, balm, cassia, cinnamon, cumin, flax, and fig. Chemical components of Aloe vera are aloin, sina...
Source: Reviews on Recent Clinical Trials - February 27, 2024 Category: Cancer & Oncology Authors: Mohamad Hesam Shahrajabian Wenli Sun Source Type: research
Carob (Ceratonia siliqua L.), Pharmacological and Phytochemical Activities of Neglected Legume of the Mediterranean Basin, as Functional Food
Rev Recent Clin Trials. 2024 Jan 26. doi: 10.2174/0115748871278128240109074506. Online ahead of print.ABSTRACTCarob (Ceratonia siliqua L.) has been widely cultivated in different parts of the world, particularly in the Mediterranean region, and the tree belongs to the family Leguminosae. Several studies have indicated that carobs and their products can improve human health and help prevent different specific chronic diseases. Carob can considered as functional food due to its high content in dietary fibers, low-fat content, and high content of minerals. Its fruit is a pod containing 10%-20% seeds, and the pods consist of s...
Source: Reviews on Recent Clinical Trials - January 30, 2024 Category: Cancer & Oncology Authors: Mohamad Hesam Shahrajabian Wenli Sun Source Type: research
Comparison of Clinical Trial Results of the Recently Approved Immunotherapeutic Drugs for Advanced Biliary Tract Cancers
Rev Recent Clin Trials. 2024 Jan 29. doi: 10.2174/0115748871276666240123043710. Online ahead of print.ABSTRACTThe recently approved immunotherapeutic drugs are Keytruda (pembrolizumab) and Imfinzi (durvalumab) for advanced biliary tract cancers that inhibit PD-1 receptor and PD-L1 ligand, respectively. In this perspective, the results of the two clinical trials, i.e., TOPAZ-1 (NCT03875235) and KEYNOTE-966 (NCT04003636), are critically appraised, compared, and discussed to assess the benefits of these two drugs in the context of the treatment of advanced biliary tract cancers with a focus on PD-L1 status and MIS (microsatel...
Source: Reviews on Recent Clinical Trials - January 30, 2024 Category: Cancer & Oncology Authors: Samayita Das Source Type: research
Carob (Ceratonia siliqua L.), Pharmacological and Phytochemical Activities of Neglected Legume of the Mediterranean Basin, as Functional Food
Rev Recent Clin Trials. 2024 Jan 26. doi: 10.2174/0115748871278128240109074506. Online ahead of print.ABSTRACTCarob (Ceratonia siliqua L.) has been widely cultivated in different parts of the world, particularly in the Mediterranean region, and the tree belongs to the family Leguminosae. Several studies have indicated that carobs and their products can improve human health and help prevent different specific chronic diseases. Carob can considered as functional food due to its high content in dietary fibers, low-fat content, and high content of minerals. Its fruit is a pod containing 10%-20% seeds, and the pods consist of s...
Source: Reviews on Recent Clinical Trials - January 30, 2024 Category: Cancer & Oncology Authors: Mohamad Hesam Shahrajabian Wenli Sun Source Type: research
