Differential Neuroplastic Changes in Fibromyalgia and Depression Indexed by Up-Regulation of Motor Cortex Inhibition and Disinhibition of the Descending Pain System: An Exploratory Study

Conclusion: These findings support the hypothesis that in FM a deteriorated function of cortical inhibition, indexed by a higher SICI parameter, a lower function of the DPMS, together with a higher level of BDNF indicate that FM has different pathological substrates from depression. They suggest that an up-regulation phenomenon of intracortical inhibitory networks associated with a disruption of the DPMS function occurs in FM. Introduction Major depressive disorder (MDD) and fibromyalgia (FM) present overlapped symptoms. Although the connection between these two disorders has not been elucidated yet, the disruption of neuroplastic processes that mediate the equilibrium in the inhibitory systems stands out as a possible mechanism. These processes comprise a central pathologic mechanism of the sensitization syndrome (CSS) (Maletic et al., 2007; Woolf, 2012). The CSS embodies the long-term consequence of an abnormal stress-response system (Lyon et al., 2011) that culminates in the amplification of sensory inputs. It covers the decline of top-down inhibitory activity (dysregulation of dopamine, serotonin, norepinephrine, epinephrine, and endogenous opioids) (Wallace and Gotto, 2008) and the enhancement of bottom-up excitatory activity. Both MDD and FM present a robust association with an imbalance of glutamatergic (Glu) and GABAergic transmission. Motor cortex disinhibition indexed by transcranial magnetic stimulation (TMS) measurements became a robust common feature of ...
Source: Frontiers in Human Neuroscience - Category: Neuroscience Source Type: research

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CONCLUSION: All of these drugs, if accepted by the patient, can also have an additional, beneficial placebo effect, with the patient calming down more rapidly than could be explained on pharmacological grounds alone. It is, therefore, important in emergencies (as at other times) for the patient to be involved in treatment decisions to the greatest possible extent. PMID: 31431244 [PubMed - in process]
Source: Deutsches Arzteblatt International - Category: General Medicine Tags: Dtsch Arztebl Int Source Type: research
CONCLUSION: This first randomized resistance training trial in pancreatic cancer patients indicated clinically relevant improve- ments in QoL after 3 but not after 6 months. Given the severity of pancreatic cancer, exercise recommendations may already commence at surgery. PMID: 31431236 [PubMed - in process]
Source: Deutsches Arzteblatt International - Category: General Medicine Tags: Dtsch Arztebl Int Source Type: research
CONCLUSION: Patients with IBS in Germany are likely not receiving sufficient diag- nostic evaluation in conformity with the relevant guidelines. The high prevalence of comorbid mental disorders and other pain syndromes implies that the complaints of patients with IBS need to be more comprehensively evaluated and treated. PMID: 31431234 [PubMed - in process]
Source: Deutsches Arzteblatt International - Category: General Medicine Tags: Dtsch Arztebl Int Source Type: research
CONCLUSIONS: Physicians reported higher perceptions of disparities in perioperative care than non-physicians, potentially explained by differences in training or contact with patients. Such findings serve as a first step at examining and discussing disparities in perioperative care and warrant further study. PMID: 31431287 [PubMed - as supplied by publisher]
Source: Journal of the National Medical Association - Category: General Medicine Tags: J Natl Med Assoc Source Type: research
Publication date: 1 October 2019Source: Sensors and Actuators A: Physical, Volume 297Author(s): Weina Liu, Xinwei Yang, Youtian Niu, Haoran SunAbstractIn this paper, a sub-wavelength resonance sensor is proposed to microwave detection applications. A meta-material element—multiple split ring resonators (MSRR) is used to improve the sensitivity of the sensor. Therefore, the sensor is based on micro-strip technology and consists of a micro-strip and a MSRR. It is observed that the strongest electric field of the sensor can achieve to 105 V/m. So the sensor is very sensitive to capture changes of dielectric signals. S...
Source: Sensors and Actuators A: Physical - Category: Physics Source Type: research
Abstract OBJECTIVES: Evaluate the relationship between arthritis diagnosis in those over 50 and exposure to extreme air pollution in utero or infancy (
Source: Environmental Pollution - Category: Environmental Health Authors: Tags: Environ Pollut Source Type: research
Discussion and conclusions: Deferasirox does not appear to be well tolerated in SCD patients older than 40 years, in which complications of the underlying disease are already fully installed. The choice of the ideal iron chelator for this population should include an evaluation of comorbidities and organic dysfunctions, as well as the need to find pharmacogenetic safety markers in this group of patients. PMID: 31434554 [PubMed - in process]
Source: Hematology - Category: Hematology Tags: Hematology Source Type: research
Publication date: 15 December 2019Source: Journal of Molecular Structure, Volume 1198Author(s): Elham Geravand, Faezeh Farzaneh, Mina GhiasiAbstractUiO-66(Zr)-V as metal organic framework was prepared by metalation of the UiO-66(Zr) nodes with VCl3. The characterization of the prepared catalyst was carried out using XRD, EDX, FT IR, BET, ICP, Raman, DRS, SEM and XPS techniques. The density functional theory (DFT) was used in order to find the most stable position of the vanadium of metallated UiO-66(Zr). It was found that UiO-66(Zr)-V has been generated via metalation of V(V) ions with two OH groups of Zr-based nodes. The ...
Source: Journal of Molecular Structure - Category: Molecular Biology Source Type: research
Publication date: 15 December 2019Source: Journal of Molecular Structure, Volume 1198Author(s): Mohd R. Razali, Stuart R. BattenAbstractThe synthesis, characterizations and crystal structures for [Cu(ipnm)(hmpH)] (1), mixed-valent tetranuclear [MnII2MnIII2(dcnm)2(hmp)6Cl2] (2) and the homo-valent hexanuclear [FeIII6(dcnm)6(hmp)8O2] (3), (where ipnm = imido[cyano (picolinoyl)methyl]nitrosomethanide, hmpH = 2-hydroxymethylpyridine; dcnm = dicyanonitrosomethanide) are reported. The formation of new dianionic ligand, ipnm which is also an imide derivative, represents the scarce example of metal-mediated in-situ deh...
Source: Journal of Molecular Structure - Category: Molecular Biology Source Type: research
Publication date: 1 November 2019Source: Journal of Molecular Liquids, Volume 293Author(s): Jun Qi, Qingjun Zhang, Xiaoyan Han, Qingpeng Wu, Yafang Li, Qunsheng LiAbstractThe formation of azeotrope makes the separation of diisopropyl ether (DIPE) and isopropanol (IPA) a challenging task. Ethylene glycol (EG) and ionic liquid 1,3-dimethylimidazolium dimethyl phosphate ([Mmim] [DMP]) were screened as entrainers for the extractive distillation process. Isobaric vapor-liquid equilibrium data of DIPE + IPA + EG and DIPE + IPA + [Mmim] [DMP] was measured through experiment. The NRTL model was applied to correlate...
Source: Journal of Molecular Liquids - Category: Molecular Biology Source Type: research
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