Differential Neuroplastic Changes in Fibromyalgia and Depression Indexed by Up-Regulation of Motor Cortex Inhibition and Disinhibition of the Descending Pain System: An Exploratory Study

Conclusion: These findings support the hypothesis that in FM a deteriorated function of cortical inhibition, indexed by a higher SICI parameter, a lower function of the DPMS, together with a higher level of BDNF indicate that FM has different pathological substrates from depression. They suggest that an up-regulation phenomenon of intracortical inhibitory networks associated with a disruption of the DPMS function occurs in FM. Introduction Major depressive disorder (MDD) and fibromyalgia (FM) present overlapped symptoms. Although the connection between these two disorders has not been elucidated yet, the disruption of neuroplastic processes that mediate the equilibrium in the inhibitory systems stands out as a possible mechanism. These processes comprise a central pathologic mechanism of the sensitization syndrome (CSS) (Maletic et al., 2007; Woolf, 2012). The CSS embodies the long-term consequence of an abnormal stress-response system (Lyon et al., 2011) that culminates in the amplification of sensory inputs. It covers the decline of top-down inhibitory activity (dysregulation of dopamine, serotonin, norepinephrine, epinephrine, and endogenous opioids) (Wallace and Gotto, 2008) and the enhancement of bottom-up excitatory activity. Both MDD and FM present a robust association with an imbalance of glutamatergic (Glu) and GABAergic transmission. Motor cortex disinhibition indexed by transcranial magnetic stimulation (TMS) measurements became a robust common feature of ...
Source: Frontiers in Human Neuroscience - Category: Neuroscience Source Type: research

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Authors: Brand C, Sehn AP, Gaya AR, Mota J, Brazosayavera J, Pollo Renner JD, Reuter CP Abstract PURPOSE: To verify the moderator role of physical fitness in the relationship betweenadiposity and cardiometabolic risk factors in normal weight and overweight/obese children and adolescents. METHODS: Cross-sectional study comprising 2482 children and adolescents, aged 7-17 years. Physical fitness was evaluated according the procedures of Projeto Esporte Brazil, and waist circumference (WC) with an inelastic tape. Cardiometabolic risk score was defined by the z-score sum of glucose, total cholesterol, high-density l...
Source: Journal of Sports Medicine and Physical Fitness - Category: Sports Medicine Tags: J Sports Med Phys Fitness Source Type: research
Authors: Latha S, Selvamani P, Prabha T Abstract Natural products have a unique place in the healthcare industry. The genus Commiphora emerged as a potential medicinal with huge benefits as evidenced through its use in various traditional and modern systems of medicine. Therefore, we aimed to prepare a concise review on the pharmacological activities and the indigenous uses of various plant species belonging to the genus Commiphora along with the structural information of various active botanical ingredients present in these plants based on the published literatures and scientific reports. To collect the various pu...
Source: Cardiovascular and Hematological Agents in Medicinal Chemistry - Category: Cardiology Tags: Cardiovasc Hematol Agents Med Chem Source Type: research
Publication date: Available online 2 July 2020Source: European UrologyAuthor(s): Mark C. Markowski, Hao Wang, Rana Sullivan, Irina Rifkind, Victoria Sinibaldi, Michael T. Schweizer, Benjamin A. Teply, Nduku Ngomba, Wei Fu, Michael A. Carducci, Channing J. Paller, Catherine H. Marshall, Mario A. Eisenberger, Jun Luo, Emmanuel S. Antonarakis, Samuel R. Denmeade
Source: European Urology - Category: Urology & Nephrology Source Type: research
BACKGROUND: It is aimed to determine the prevalence of suicidal behaviors regarding to epidemiological and psychosocial characteristics among Bruneian school-student adolescents. Methods: The cross-sectional study of 2599 (female: 49.9%; mean: 14.7 y...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
Non-suicidal self-injury is a significant global public health problem during adolescence, nevertheless there is a lack of investigations among juvenile offenders. Our cross-sectional study aimed to investigate the relationship between negative life events...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
Emotion dysregulation is implicated in both suicide attempts (SA) and non-suicidal self-injury (NSSI). However, little is known about how emotion dysregulation may differ between adolescents who have made an SA from those engaged in NSSI. We sought to addr...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
Based on attachment theory and a social-cognitive model of posttraumatic stress disorder (PTSD), this study examined the roles of parent-child communication, perceived parental depression, and intrusive rumination in the association between insecure attach...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
Chronic pain is a complex experience that has now become a major public health issue. This has prompted many researchers to study attention, understanding it to be a crucial factor that allows altering the experience of pain, while attributing considerable...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Elder Adults Source Type: news
Care about people with disabilities is very important for every community, special for safe community. In Safe Community Novi Sad works Nongovernmental organization Faith, Love, Hope. This organization was founded on March 2010. To promote the idea of soci...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Infants and Children Source Type: news
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Source: SafetyLit - Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news
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