Association of benzodiazepines, Z-drugs, pregabalin, and melatonin with traffic accidents: a nationwide cohort and case-crossover study in Danish adults - Osler M, J ørgensen MB.
BACKGROUND: Benzodiazepines, Z-drugs, pregabalin, and melatonin (BZPMs) have been associated with a higher risk of traffic accidents, but the evidence is inconsistent, and lacking for newer drugs. AIM: To examine the association of BZPMs with risk ... (Source: SafetyLit)
Source: SafetyLit - May 2, 2022 Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news

Association of co-prescribing of opioid and benzodiazepine substitutes with incident falls and fractures among older adults: a cohort study - Shah R, Raji MA, Westra J, Kuo YF.
OBJECTIVE: Examine the association between the co-prescribing of opioids, benzodiazepines, gabapentinoids (pregabalin and gabapentin) and selective serotonin reuptake inhibitors/serotonin and norepinephrine reuptake inhibitors (SSRI/SNRIs) in different com... (Source: SafetyLit)
Source: SafetyLit - April 30, 2022 Category: International Medicine & Public Health Tags: Age: Elder Adults Source Type: news

Drug safety update. Pregabalin (Lyrica): findings of safety study on risks during pregnancy
The Medicines and Healthcare products Regulatory Agency has issued a drug safety update following the findings of a safety study on the use of pregabalin during pregnancy. An observational study of m (Source: Royal Pharmaceutical Society News)
Source: Royal Pharmaceutical Society News - April 20, 2022 Category: Drugs & Pharmacology Source Type: news

The Effects of Pregabalin vs Placebo on Functional Dyspepsia The Effects of Pregabalin vs Placebo on Functional Dyspepsia
Might the gabapentinoid pregabalin be a safe and effective treatment option for functional dyspepsia?Alimentary Pharmacology & Therapeutics (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - November 1, 2021 Category: Consumer Health News Tags: Gastroenterology Journal Article Source Type: news

Pregabalin poisoning: evaluation of dose-toxicity relationship - Rietjens SJ, Sikma MA, Hunault CC, de Lange DW, Hondebrink L.
CONTEXT: Pregabalin poisoning is mostly benign, although coma and convulsions occasionally occur. AIM: To determine the dose-toxicity relationship of pregabalin. METHODS: Dose-toxicity data of isolated pregabalin poisonings was collected fr... (Source: SafetyLit)
Source: SafetyLit - September 18, 2021 Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news

The occurence and relevance of Pregabalin in traffic offences. A prevalence study - Szewczyk A, Hof C, Muller A, Kocyigit D, Jungen H, Aboutara N, Iwersen-Bergmann S, Andresen-Streichert H.
The aim of the study was to determine the occurrence and relevance of Pregabalin - an anticonvulsant drug - in traffic offences. A total prevalence of 3.3 % was detected in the areas of Hamburg, K öln and Aachen. Judged by the identification of at least on... (Source: SafetyLit)
Source: SafetyLit - September 18, 2021 Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news

Pregabalin and gabapentin in non-opioid poisoning deaths - Kriikku P, Ojanper ä I.
Post-mortem findings of gabapentinoids have often been connected to drug abuse and especially opioid use. We aimed to investigate whether gabapentinoids have been implicated in the cause of death without the presence of opioids. In a three-year study perio... (Source: SafetyLit)
Source: SafetyLit - May 20, 2021 Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news

Hooked on the ANXIETY pills experts are calling the new VALIUM
Sharon Davies has a simple message for anyone whose GP recommends they start taking the drug pregabalin to deal with anxiety. 'Don't,' she says. 'Please, just don't.' (Source: the Mail online | Health)
Source: the Mail online | Health - April 26, 2021 Category: Consumer Health News Source Type: news

Increase in pregabalin recreational use in adolescents in France - Dufayet L, Car é W, Deheul S, Laborde-Casterot H, Nisse P, Langrand J, Vodovar D.
This study aims to describe this new and specific po... (Source: SafetyLit)
Source: SafetyLit - March 22, 2021 Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news

Profile of substance misuse among adolescent and young adult gabapentinoid users: a register-based follow-up study of former adolescent psychiatric inpatients - Peltokorpi J, Hakko H, Riipinen P, Riala K.
Our study examined characteristics of adolescent and young adult study participants using gabapentinoids (gabapentin, pregabalin), with previous history of adolescent psychiatric inpatient hospitalization. Particular focus was on temporal association of ag... (Source: SafetyLit)
Source: SafetyLit - March 11, 2021 Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news

Gabapentinoid abuse in France: evidence on health consequences and new points of vigilance - Tambon M, Pont é C, Jouanjus E, Fouilhé N, Micallef J, Lapeyre-Mestre M.
This study aims to describe clinical characteristics of gabapentinoi... (Source: SafetyLit)
Source: SafetyLit - February 25, 2021 Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news

Unintentional exposure to pregabalin in ≤6-year-old children: a nationwide French Poison Control Center study - Dufayet L, Monnet F, Laborde-Casterot H, Caré W, Lekens B, Langrand J, French Poison Control Centers Research Network, Megarbane B, Vodovar D.
INTRODUCTION: In France, pregabalin is widely prescribed in adults but still not approved for children. We aimed to investigate the incidence of pregabalin exposure in ≤6-year-old children, to describe the characteristics and outcome of ingestions involv... (Source: SafetyLit)
Source: SafetyLit - October 5, 2020 Category: International Medicine & Public Health Tags: Age: Infants and Children Source Type: news

Corrigendum to "A repeated cross-sectional study of factors associated with pregabalin-positive poisoning deaths in Ireland" [Drug Alcohol Depend. 206 (2020) 107741] - Lynn E, Cousins G, Lyons S, Bennett KE.
The authors regret that there were two typographical errors in the Results section of the abstract of the published article. Please see below for the corrected abstract in full. Background: The increasing use of pregabalin and the presence of pre... (Source: SafetyLit)
Source: SafetyLit - March 30, 2020 Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news

La FDA advierte acerca de problemas respiratorios graves con los medicamentos para convulsiones y dolor neural gabapentina (Neurontin, Gralise, Horizant) y pregabalina (Lyrica, Lyrica CR)
La Administraci ón de Alimentos y Medicamentos de EE. UU. (FDA) advierte que los pacientes con factores de riesgo respiratorio que usan gabapentina (Neurontin, Gralise, Horizant) o pregabalina (Lyrica, Lyrica CR) pueden sufrir graves dificultades respiratorias. (Source: FDA Center for Drug Evaluation and Research - What's New)
Source: FDA Center for Drug Evaluation and Research - What's New - January 30, 2020 Category: Drugs & Pharmacology Authors: FDA Source Type: news

Withdrawal, dependence and adverse events of antidepressants: lessons from patients and data
Tolerability, withdrawal effects and dependence on prescription medication is an important topic of current scientific and clinical debate, as highlighted by the recent report published on September 2019 by Public Health England (https://www.gov.uk/government/publications/prescribed-medicines-review-report).1 This was a mixed methods public health review of available evidence in adults focusing on specific issues of dependence and withdrawal associated with five groups of medications: (1) benzodiazepines, (2) z-drugs, (3) gabapentin and pregabalin, (4) opioids and (5) antidepressants. The evidence included in the review co...
Source: Current Awareness Service for Health (CASH) - January 24, 2020 Category: Consumer Health News Source Type: news