Withdrawal, dependence and adverse events of antidepressants: lessons from patients and data
Tolerability, withdrawal effects and dependence on prescription medication is an important topic of current scientific and clinical debate, as highlighted by the recent report published on September 2019 by Public Health England (https://www.gov.uk/government/publications/prescribed-medicines-review-report).1 This was a mixed methods public health review of available evidence in adults focusing on specific issues of dependence and withdrawal associated with five groups of medications: (1) benzodiazepines, (2) z-drugs, (3) gabapentin and pregabalin, (4) opioids and (5) antidepressants. The evidence included in the review co...
Source: Current Awareness Service for Health (CASH) - January 24, 2020 Category: Consumer Health News Source Type: news

FDA warns about serious breathing problems with seizure and nerve pain medicines gabapentin (Neurontin, Gralise, Horizant) and pregabalin (Lyrica, Lyrica CR)
Listen to an audio podcast of the December 19, 2019 FDA Drug Safety Communication warning that serious breathing difficulties may occur in patients using seizure and nerve pain medicines gabapentin (Neurontin, Gralise, Horizant) and pregabalin (Lyrica, Lyrica CR) who have respiratory risk factors. (Source: FDA Center for Drug Evaluation and Research - What's New)
Source: FDA Center for Drug Evaluation and Research - What's New - January 2, 2020 Category: Drugs & Pharmacology Authors: FDA Source Type: news

Off-Label Use of Gabapentinoids: A New Paradigm
Several of the hot topics in geriatrics are pain management, medication reduction/deprescribing, and use of off-label medications. Best-practice use of gabapentinoids — gabapentin (Neurontin) and pregabalin (Lyrica) — comfortably fits into all three categories. Examination of the evidence may help health care practitioners make better decisions when prescribing these medications. (Source: Caring for the Ages)
Source: Caring for the Ages - December 25, 2019 Category: Health Management Authors: Daniel Haimowitz, Jeanne Manzi Source Type: news

Neurontin, Gralise, Horizant (gabapentin) and Lyrica, Lyrica CR (pregabalin): Drug Safety Communication - Serious Breathing Problems
FDA is warning that serious breathing difficulties may occur in patients using gabapentin or pregabalin who have respiratory risk factors. (Source: FDA Center for Drug Evaluation and Research - What's New)
Source: FDA Center for Drug Evaluation and Research - What's New - December 20, 2019 Category: Drugs & Pharmacology Authors: FDA Source Type: news

FDA warns about serious breathing problems with seizure and nerve pain medicines gabapentin (Neurontin, Gralise, Horizant) and pregabalin (Lyrica, Lyrica CR)
Taking gabapentin or pregabalin with opioids, anxiety meds or antidepressants, or if you have lung issues or are elderly, can lead to serious breathing problems. Watch for breathing issues, confusion, dizziness, or extreme sleepiness. (Source: FDA Center for Drug Evaluation and Research - What's New)
Source: FDA Center for Drug Evaluation and Research - What's New - December 19, 2019 Category: Drugs & Pharmacology Authors: FDA Source Type: news

A repeated cross-sectional study of factors associated with pregabalin-positive poisoning deaths in Ireland - Lynn E, Cousins G, Lyons S, Bennett KE.
In this study we examined factors associated with pregabalin-positive poisoning deaths (P... (Source: SafetyLit)
Source: SafetyLit - November 28, 2019 Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news

Steep Jump in Gabapentinoid Use Among US Patients With Cancer Steep Jump in Gabapentinoid Use Among US Patients With Cancer
The use of gabapentin and pregabalin doubled between 2005 and 2015 among US patients with cancer; experts say these drugs may be appropriate, but warn about adverse effects and potential for abuse.Medscape Medical News (Source: Medscape Hematology-Oncology Headlines)
Source: Medscape Hematology-Oncology Headlines - November 7, 2019 Category: Cancer & Oncology Tags: Hematology-Oncology News Source Type: news

The impact of the sepsis on female urogenital system: the role of pregabalin
The aim of the study was to investigate the oxidative damage and inflammatory effects of sepsis on the urogenital system in the Lipopolysaccharide (LPS)-induced sepsis model and ameliorating role of Pregabalin (PGB). These findings demonstrated that sepsis caused oxidative stress and inflammation in the urogenital tissues. We have revealed that PGB ameliorated tissue damage caused by sepsis. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - October 30, 2019 Category: Consumer Health News Source Type: news

Two Sentenced for Participating in Online Drug Distribution and Money Laundering Scheme
Zuned Sunesra, Mumbai, India, Taimur Khan, Surrey, British Columbia, conspiracy, pharmacy websites, online pharmacy, emedoutlet.com, Asian Capital Equities, Soma, Provigil, Darvocet, Darvocet-N, Meridia, Lyrica, mygiftcard.biz, illegal medications, (Source: Office of Criminal Investigations (OCI) Press Releases)
Source: Office of Criminal Investigations (OCI) Press Releases - October 11, 2019 Category: Medical Law Authors: DOJ Source Type: news

Dishing out more drugs won ’t stop the pain. Doctors need new tools | Ann Robinson
As a GP, I know opioids have their place. But we shouldn ’t be complacent about a US-style crisis happening in BritainGrowing concern about the prescription of drugs that cause dependence has been backed up by a recent report from Public Health England (PHE). The agencydiscovered that in 2017-18, 13% of adults in England received at least one prescription for opioids such as morphine or oxycodone (although this represented a slight downturn in prescribing after a long upward trend). Other drug classes were implicated too, with 25% of adults prescribed one or more of the following drugs: benzodiazepines (such as Valiu...
Source: Guardian Unlimited Science - September 15, 2019 Category: Science Authors: Ann Robinson Tags: Opioids GPs NHS Doctors Health Society Drugs policy Politics Science UK news Source Type: news

FDA approves first generics of Lyrica
(pregabalin) (Source: FDA Center for Drug Evaluation and Research - What's New)
Source: FDA Center for Drug Evaluation and Research - What's New - September 11, 2019 Category: Drugs & Pharmacology Authors: FDA Source Type: news

Pregabalin, Ketamine to Prevent Pain After Cardiac Surgery Pregabalin, Ketamine to Prevent Pain After Cardiac Surgery
This study assessed the effect of a prolonged regimen of preventive analgesia with pregabalin alone or in combination with ketamine.Anesthesiology (Source: Medscape General Surgery Headlines)
Source: Medscape General Surgery Headlines - August 8, 2019 Category: Surgery Tags: Anesthesiology Journal Article Source Type: news

FDA Grants First Approvals for Generic Versions of Lyrica
Title: FDA Grants First Approvals for Generic Versions of LyricaCategory: Health NewsCreated: 7/23/2019 12:00:00 AMLast Editorial Review: 7/24/2019 12:00:00 AM (Source: MedicineNet Chronic Pain General)
Source: MedicineNet Chronic Pain General - July 24, 2019 Category: Anesthesiology Source Type: news

FDA Grants First Approvals for Generic Versions of Lyrica
TUESDAY, July 23, 2019 -- Nine drug companies have received approval for the first generic versions of Lyrica (pregabalin), the U.S. Food and Drug Administration announced. The generic versions of Lyrica have been approved to manage neuropathic... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - July 23, 2019 Category: General Medicine Source Type: news

Pfizer ’s Lyrica officially drops off the patent cliff
It was great while it lasted. But Pfizer ’s blockbuster drug, Lyrica, is now officially facing generics competition. (Source: PharmaManufacturing.com)
Source: PharmaManufacturing.com - July 22, 2019 Category: Pharmaceuticals Source Type: news

FDA Approves First Generics of Lyrica
July 22, 2019 -- On July 19, the U.S. Food and Drug Administration approved multiple applications for first generics of Lyrica (pregabalin) for the management of neuropathic pain associated with diabetic peripheral neuropathy, for the management of... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - July 22, 2019 Category: Pharmaceuticals Source Type: news

FDA approves 9 generic versions of nerve pain drug Lyrica
FDA approves first generic copies of a popular pill for nerve pain (Source: ABC News: Health)
Source: ABC News: Health - July 22, 2019 Category: Consumer Health News Tags: Health Source Type: news

FDA Grants First Approvals for Generic Versions of Lyrica
MONDAY, July 22, 2019 -- Nine drug companies have received approval for the first generic versions of Lyrica (pregabalin), the U.S. Food and Drug Administration announced today. The generic versions of Lyrica have been approved to manage neuropathic... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - July 22, 2019 Category: Pharmaceuticals Source Type: news

FDA Approves First Lyrica Generics FDA Approves First Lyrica Generics
The US FDA has approved multiple applications for the first generics of pregabalin (Lyrica) for the management of neuropathic pain.FDA Approvals (Source: Medscape Internal Medicine Headlines)
Source: Medscape Internal Medicine Headlines - July 22, 2019 Category: Internal Medicine Tags: Neurology & Neurosurgery News Alert Source Type: news

FDA approves first generics of Lyrica
On July 19, the U.S. Food and Drug Administration approved multiple applications for first generics of Lyrica (pregabalin) for the management of neuropathic pain associated with diabetic peripheral neuropathy, for the management of postherpetic neuralgia, as an adjunctive therapy for the treatment of partial onset seizures in patients 17 years of age and older, for the management of fibromyalgia, and for the management of neuropathic pain associated with spinal cord injury. (Source: World Pharma News)
Source: World Pharma News - July 22, 2019 Category: Pharmaceuticals Tags: Featured FDA Regulatory Affairs Source Type: news

Gabapentinoids used Off-label for Pain: Effective or Erroneous?
Off-label gabapentin and pregabalin prescribing for pain is widespread; the opioid crisis may be to blame. But does science support the trend? Find out with these 10 questions. (Source: ConsultantLive)
Source: ConsultantLive - June 21, 2019 Category: Internal Medicine Authors: Steven A. King, MD, MS Tags: Pain Source Type: news

Common nerve pain drug linked to suicidal behavior, overdose
(Reuters Health) - A class of medications used for nerve and muscle pain, including the popular drug Lyrica, increases users' risks for suicidal behavior, unintentional overdoses, injuries and car accidents - and the risks are particularly high for teens and young adults, new research shows. (Source: Reuters: Health)
Source: Reuters: Health - June 17, 2019 Category: Consumer Health News Tags: healthNews Source Type: news

Epilepsy Drug Linked to Suicide Risk in Young
The medicine, pregabalin (Lyrica), comes from a class of drugs called gabapentinoids. (Source: WebMD Health)
Source: WebMD Health - June 14, 2019 Category: Consumer Health News Source Type: news

Epilepsy Drug Pregabalin (Lyrica) Tied to Higher Risk of Suicidal Behavior in Young Users
THURSDAY, June 13, 2019 -- A new study supports the notion that a drug used to control epilepsy and other disorders could make some young people more prone to suicide. The medicine, pregabalin (Lyrica), comes from a class of drugs called... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - June 13, 2019 Category: General Medicine Source Type: news

Pfizer announces top-line results from Phase 3 Trial of LYRICA ® (pregabalin) in primary generalized tonic-clonic seizures
Pfizer Inc. (NYSE: PFE) announced today that a Phase 3 study to assess the use of LYRICA® (pregabalin) as adjunctive therapy for epilepsy patients 5 to 65 years of age with primary generalized tonic-clonic (PGTC) seizures did not meet its primary endpoint. Treatment with LYRICA did not result in a statistically significant reduction in seizure frequency versus placebo. (Source: World Pharma News)
Source: World Pharma News - May 24, 2019 Category: Pharmaceuticals Tags: Featured Pfizer Business and Industry Source Type: news

Gabapentin and Pregabalin for Pain in Children, Adolescents Gabapentin and Pregabalin for Pain in Children, Adolescents
What is the current evidence for the safety and efficacy of gabapentin and pregabalin for neuropathic and postoperative pain in children and adolescents?Anesthesia & Analgesia (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - April 5, 2019 Category: Consumer Health News Tags: Anesthesiology Journal Article Source Type: news

Pregabalin/Lyrica reclassified to a class C drug
The move comes after Pregabalin/Lyrica was linked to 33 deaths in Northern Ireland in 2017. (Source: BBC News | Health | UK Edition)
Source: BBC News | Health | UK Edition - April 1, 2019 Category: Consumer Health News Source Type: news

Rescheduling of gabapentin and pregabalin to Schedule 3 Controlled Drugs from 1 April 2019
Gabapentin and Pregabalin will be reclassified to Schedule 3 Controlled Drugs (CDs) from 1 April 2019. (Source: Royal Pharmaceutical Society News)
Source: Royal Pharmaceutical Society News - March 29, 2019 Category: Drugs & Pharmacology Source Type: news

Rescheduling of gabapentin and pregabalin to Schedule 3 Controlled Drugs from 1 April 2019
Gabapentin and pregabalin will be reclassified to Schedule 3 Controlled Drugs (CDs). This means from 1 April 2019: Prescriptions for gabapentin and pregabalin need to meet full prescription require (Source: Royal Pharmaceutical Society News)
Source: Royal Pharmaceutical Society News - March 12, 2019 Category: Drugs & Pharmacology Source Type: news

The Health 202: Drug executives may have to defend these expensive medicines to Congress
Think Lyrica, Crestor, Keytruda. (Source: Washington Post: To Your Health)
Source: Washington Post: To Your Health - February 25, 2019 Category: Consumer Health News Authors: Paige Winfield Cunningham Source Type: news

Pregabalin vs Gabapentin: A 10-question Quiz
Gabapentin and pregabalin have become popular alternatives to opioids for pain management. See what you  really know with our quick quiz.  (Source: ConsultantLive)
Source: ConsultantLive - February 14, 2019 Category: Internal Medicine Authors: Steven King, MD, MS Tags: Pain Source Type: news

Rescheduling of Gabapentin and Pregabalin to Schedule 3 Controlled Drugs from 1 April 2019
Gabapentin and Pregabalin will be reclassified to Schedule 3 Controlled Drugs (CDs). (Source: Royal Pharmaceutical Society News)
Source: Royal Pharmaceutical Society News - February 13, 2019 Category: Drugs & Pharmacology Source Type: news

Pregabalin misuse-related ambulance attendances in Victoria, 2012-2017: characteristics of patients and attendances - Crossin R, Scott D, Arunogiri S, Smith K, Dietze PM, Lubman DI.
OBJECTIVE: To compare changes in pregabalin prescribing and misuse-related ambulance attendances; to characterise the patients attended by paramedics for pregabalin misuse-related harms; to assess the association of pregabalin misuse with use of other seda... (Source: SafetyLit)
Source: SafetyLit - February 5, 2019 Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news

Pregabalin misuse: the next wave of prescription medication problems - Murnion B, Conigrave KM.
[Abstract unavailable] Language: en... (Source: SafetyLit)
Source: SafetyLit - February 5, 2019 Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news

Evaluation of pregabalin-induced adverse events related to falls using the FDA adverse event reporting system and Japanese Adverse Drug Event Report databases - Mukai R, Hasegawa S, Umetsu R, Nakao S, Shimada K, Uranishi H, Masuta M, Suzuki H, Nishibata Y, Nakamura M.
WHAT IS KNOWN AND OBJECTIVE: Pregabalin is used for neuropathic and postherpetic pain and generalized anxiety. The aim of this study was to obtain the onset profiles of adverse events (AE) related to falls (AEFs) such as "somnolence," "dizziness," "loss of... (Source: SafetyLit)
Source: SafetyLit - December 25, 2018 Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news

Lyrica (pregabalin) vs. Klonopin (clonazepam)
Title: Lyrica (pregabalin) vs. Klonopin (clonazepam)Category: MedicationsCreated: 12/18/2018 12:00:00 AMLast Editorial Review: 12/18/2018 12:00:00 AM (Source: MedicineNet Medications General)
Source: MedicineNet Medications General - December 18, 2018 Category: Drugs & Pharmacology Source Type: news

Lyrica vs. Hydrocodone
Title: Lyrica vs. HydrocodoneCategory: MedicationsCreated: 12/18/2018 12:00:00 AMLast Editorial Review: 12/18/2018 12:00:00 AM (Source: MedicineNet Medications General)
Source: MedicineNet Medications General - December 18, 2018 Category: Drugs & Pharmacology Source Type: news

Off-Label Drug Research Generates'Medical Uncertainty'Off-Label Drug Research Generates'Medical Uncertainty '
Research that explores/supports off-label use of pregabalin and other medications may be misleading if early promising results are not subsequently validated, investigators suggest in a new review.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - December 14, 2018 Category: Consumer Health News Tags: Neurology & Neurosurgery News Source Type: news

Lyrica (pregabalin) vs. Topamax (topiramate)
Title: Lyrica (pregabalin) vs. Topamax (topiramate)Category: MedicationsCreated: 12/11/2018 12:00:00 AMLast Editorial Review: 12/11/2018 12:00:00 AM (Source: MedicineNet Medications General)
Source: MedicineNet Medications General - December 11, 2018 Category: Drugs & Pharmacology Source Type: news

Lyrica (pregabalin) vs. Savella (milnacipran)
Title: Lyrica (pregabalin) vs. Savella (milnacipran)Category: MedicationsCreated: 12/11/2018 12:00:00 AMLast Editorial Review: 12/11/2018 12:00:00 AM (Source: MedicineNet Medications General)
Source: MedicineNet Medications General - December 11, 2018 Category: Drugs & Pharmacology Source Type: news

Lyrica (pregabalin) vs. Cymbalta (duloxetine)
Title: Lyrica (pregabalin) vs. Cymbalta (duloxetine)Category: MedicationsCreated: 12/11/2018 12:00:00 AMLast Editorial Review: 12/11/2018 12:00:00 AM (Source: MedicineNet Medications General)
Source: MedicineNet Medications General - December 11, 2018 Category: Drugs & Pharmacology Source Type: news

Lyrica (pregabalin) vs. Norco (hydrocodone and acetaminophen)
Title: Lyrica (pregabalin) vs. Norco (hydrocodone and acetaminophen)Category: MedicationsCreated: 12/11/2018 12:00:00 AMLast Editorial Review: 12/11/2018 12:00:00 AM (Source: MedicineNet Medications General)
Source: MedicineNet Medications General - December 11, 2018 Category: Drugs & Pharmacology Source Type: news

Lyrica vs. Tramadol
Title: Lyrica vs. TramadolCategory: MedicationsCreated: 12/10/2018 12:00:00 AMLast Editorial Review: 12/10/2018 12:00:00 AM (Source: MedicineNet Medications General)
Source: MedicineNet Medications General - December 10, 2018 Category: Drugs & Pharmacology Source Type: news

Lyrica (pregabalin) vs. Xanax (alprazolam)
Title: Lyrica (pregabalin) vs. Xanax (alprazolam)Category: MedicationsCreated: 12/6/2018 12:00:00 AMLast Editorial Review: 12/6/2018 12:00:00 AM (Source: MedicineNet Medications General)
Source: MedicineNet Medications General - December 6, 2018 Category: Drugs & Pharmacology Source Type: news

UK Supreme Court ruling over pregabalin could cost Pfizer £500m
(Source: PharmacoEconomics and Outcomes News)
Source: PharmacoEconomics and Outcomes News - December 1, 2018 Category: Drugs & Pharmacology Source Type: news

Pfizer scores six month extension for Lyrica patent
The FDA has handed a consolation prize to Pfizer, which is on the cusp of completely losing its patent on the company ’s best-selling drug, Lyrica. (Source: PharmaManufacturing.com)
Source: PharmaManufacturing.com - November 29, 2018 Category: Pharmaceuticals Source Type: news

Pfizer loses major patent battle in the U.K.
Lyrica has officially fallen off the patent cliff in Britain. (Source: PharmaManufacturing.com)
Source: PharmaManufacturing.com - November 14, 2018 Category: Pharmaceuticals Source Type: news

Pfizer loses drug patent fight in UK top court, may face claims
Pfizer lost the final round in a lengthy patent battle in Britain on Wednesday after the country's highest court ruled against it in a case involving its $5 billion-a-year pain drug Lyrica, exposing the company to possible financial claims. (Source: Reuters: Health)
Source: Reuters: Health - November 14, 2018 Category: Consumer Health News Tags: healthNews Source Type: news

Pfizer loses blockbuster drug patent fight in UK Supreme Court
Pfizer lost the final round in a long-running patent battle in Britain on Wednesday after the country's highest court ruled against it in a case involving its $5 billion-a-year pain drug Lyrica. (Source: Reuters: Health)
Source: Reuters: Health - November 14, 2018 Category: Consumer Health News Tags: healthNews Source Type: news

Smaller scrips for opioids linked to lower consumption
Quantity of opioids prescribed post-surgery even more strongly linked to higher patient use than pain level Related items fromOnMedica Pregabalin not effective for chronic pain after traumatic nerve injury Prescribe higher dose opioids for shorter time after surgery GP prescribing of opioids is still rising US Painkiller restrictions linked to rise in illegal drug trading England has clear North-South chronic pain divide (Source: OnMedica Latest News)
Source: OnMedica Latest News - November 8, 2018 Category: UK Health Source Type: news