A Novel RNF139 Mutation in Hemangioblastomas: Case Report
This report supports that the novel mutation of RNF139 p.Q650R probably serve as a key role in HBs progression. Introduction Central nervous system hemangioblastomas (HBs) are benign tumors which usually occur in cerebellum (1), and the pathogenesis of HBs is still unknown. According to the revised World Health Organization (WHO) classification of tumors of the nervous system published in 2000, HBs were classified to the tumors of uncertain histogenesis. The morphology code of the International Classification of Diseases for Oncology (ICD-O)is 9161/1, grade I. HBs are composed of mesenchymal cells and abundant capillaries, so it can also be called as capillary HBs. Some patients are accompanied with Von Hippel-Lindau (VHL) disease (2). VHL, an autosomal dominant hereditary disease, is one of the familial neoplastic syndromes affecting the nervous system (3). It has a broad spectrum of clinical manifestation, in which about 40 different lesions in 14 organs have been described. It is characterized by the occurrence of retinal or central nervous system HBs, renal clear-cell carcinoma, pheochromocytoma, pancreatic, and internal auditorytumors (4, 5), resulting from the germline mutation of the VHL tumor suppressor gene located on chromosome 3P25-26. The prevalence of VHL ranges from 1: 36,000 to 1: 45,500 (6). Males and females are equally affected. In clinic, HBs patients often show progressively increasing intracranial pressure with unilateral cerebellar dysfunction, ...
Authors: Wang X, Wen Y, Xue L, Lu R, Tang H, Gao N, Zhang J, Xue Q PMID: 31961109 [PubMed - as supplied by publisher]
Authors: Wang P, Xue L, Wang L, Tang H, Lv C, Xue Q PMID: 31961108 [PubMed - as supplied by publisher]
Authors: Wu G, Ke J, Wang J, Zhu X, Xiong S PMID: 31961113 [PubMed - as supplied by publisher]
Travel links to city shut down in bid to curb worst viral outbreak since Sars in 2003
Postoperative management of hallux valgus varies widely. Setting preoperative expectations is an important aspect of attaining a successful outcome, but this is not routinely reviewed in the literature. This chapter offers suggestions on successfully navigating this area of patient care. Current concepts focus on pain control, immobilization, and return to activities. This chapter also reviews the current literature in these areas and sets out the authors ’ preferred management in the postoperative setting.
Publication date: Available online 23 January 2020Source: Journal of Minimally Invasive GynecologyAuthor(s): Prathiba M. De Silva, Ayesha Mahmud, Paul P. Smith, T. Justin ClarkAbstractObjectiveTo identify the most effective analgesia for women undergoing office hysteroscopy.Data sourcesMedline, Embase, CINAHL and the Cochrane library were searched from inception until August 2019 investigating the effect of different analgesics on pain control in office hysteroscopy.Methods of study selectionRandomised controlled trials were included that investigated the effect of analgesics on pain experienced by women undergoing diagnos...
Publication date: Available online 23 January 2020Source: Journal of Minimally Invasive GynecologyAuthor(s): Whitney Trotter Ross, Jordan M. Newell, Richard Zaino, Allen R. Kunselman, Gerald J. Harkins, Andrea S. BentonAbstractStudy ObjectiveTo evaluate the diagnosis of appendiceal endometriosis in coincidental appendectomy specimens using a standard versus modified histopathologic analysis.DesignProspective analysis of 300 consecutive patients undergoing coincidental appendectomy at time of a primary gynecologic procedure.SettingAcademic tertiary referral hospital in the Northeastern United States.PatientsWomen ages 22 to...
Anterior-dominant prostate cancer is harder to detect and presents with higher prostate-specific antigen (PSA) levels than prostate cancer in other locations, according to a database study.Reuters Health Information
Publication date: Available online 21 January 2020Source: Advances in Space ResearchAuthor(s): Zhenghai Wang, Cong Zhou, Haoyang QinAbstractAdvanced space-borne thermal emission and reflection radiometer (ASTER) data were evaluated for the hydrothermal alteration mapping of the Nimu porphyry copper deposit, southern Tibet. According to the metallogenic model for porphyry copper, we chose hydrothermal alteration mineral association and then established a remote sensing model. Relative absorption-band depth (RBD) and simple band combination methods in visible near infrared (VNIR) and shortwave infrared (SWIR) bands were used...
An outbreak of new coronavirus in China has sickened more than 500 people and killed at least a dozen, while spreading to countries around the world.
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