Chemical Profiling and Biological Screening of Some River Nile Derived-Microorganisms

Conclusion: The River Nile could be a new source for production of promising bioactive leading compound where antimicrobial and antiparasitic activities may be correlated. Introduction Nature is an exceptional resource of new biologically active compounds with an astonishing chemical diversity such as that found in plant species, animals, and microorganisms (Butler et al., 2014). Microbial diversity constitutes an infinite pool of novel chemistry, making up a valuable source for innovative biotechnology (Bérdy, 2005; Fenical and Jensen, 2006). The aquatic environment is now becoming more appreciated as a rich reservoir of new natural products. Ghana and other sub-Saharan African countries are considered as a source of a diverse array of aquatic habitats (Adelaide et al., 2012). In 2012, antibiotic-producing microorganisms were isolated from the Bosomtwe Lake, River Wiwi at KNUST campus and the Gulf of Guinea at Duakor Sea beach. About 27 isolates, out of the 119 recovered, have produced metabolites with antibacterial activity against at least one of the test organisms. The crude extract of the isolate MAI2 (a strain of Pseudomonas aeruginosa) was active against all tested organisms; Bacillus thuringiensis, Proteus vulgaris, Enterococcus faecalis, Staphylococcus aureus, B. subtilis, Escherichia coli, S. typhi, and Candida albicans with MICs ranging between 250 and 2000 μg/mL (Adelaide et al., 2012). A total of 230 Actinomycetes were recovered from the so...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research