Chemical Profiling and Biological Screening of Some River Nile Derived-Microorganisms

Conclusion: The River Nile could be a new source for production of promising bioactive leading compound where antimicrobial and antiparasitic activities may be correlated. Introduction Nature is an exceptional resource of new biologically active compounds with an astonishing chemical diversity such as that found in plant species, animals, and microorganisms (Butler et al., 2014). Microbial diversity constitutes an infinite pool of novel chemistry, making up a valuable source for innovative biotechnology (Bérdy, 2005; Fenical and Jensen, 2006). The aquatic environment is now becoming more appreciated as a rich reservoir of new natural products. Ghana and other sub-Saharan African countries are considered as a source of a diverse array of aquatic habitats (Adelaide et al., 2012). In 2012, antibiotic-producing microorganisms were isolated from the Bosomtwe Lake, River Wiwi at KNUST campus and the Gulf of Guinea at Duakor Sea beach. About 27 isolates, out of the 119 recovered, have produced metabolites with antibacterial activity against at least one of the test organisms. The crude extract of the isolate MAI2 (a strain of Pseudomonas aeruginosa) was active against all tested organisms; Bacillus thuringiensis, Proteus vulgaris, Enterococcus faecalis, Staphylococcus aureus, B. subtilis, Escherichia coli, S. typhi, and Candida albicans with MICs ranging between 250 and 2000 μg/mL (Adelaide et al., 2012). A total of 230 Actinomycetes were recovered from the soil o...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research

Related Links:

[Helping people to help themselves : 10 years of successful graduate medical training in otorhinolaryngology in Rwanda (Africa)]. HNO. 2019 May 22;: Authors: Dazert S, Heinrich D Abstract After the horrifying genocide in Rwanda in 1994, medical care of the small country almost broke down completely. During the following years, different medical fields had to be redeveloped. However, until 2009, there was no training program for otorhinolaryngology offered in Rwanda. Together with the University of Rwanda, we established a Master of Medicine Program that started in 2010. With the support of Ge...
Source: HNO - Category: ENT & OMF Tags: HNO Source Type: research
Authors: Harada K, Yasuda M, Hasegawa K, Yamazaki Y, Sasano H, Otsuka F Abstract Adrenocortical carcinoma (ACC) is a rare malignancy arising from adrenocortical parenchymal cells. Myxoid ACC is one of the newly identified, rare, but important histological variants of ACC, characterized by the presence of abundant extracellular Alcian Blue-positive myxoid material. Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant cancer predisposition syndrome, and the incidence of ACC in MEN1 patients has been reported to be between 1.4% and 6%. Here, we report the case of a 68-year-old Japanese woman harboring t...
Source: Endocrine Journal - Category: Endocrinology Tags: Endocr J Source Type: research
This study aimed to investigate if hyperinsulinemia and/or insulin resistance was correlated with the occurrence of papillary thyroid cancer (PTC) in a group of Chinese patients. 258 inpatients were included in the study. According to the postoperative pathology results, all subjects were divided into PTC (n = 153) and control groups (with benign thyroid nodules, n = 105). Body mass index (BMI), fasting glucose, fasting insulin, homeostasis model assessment of insulin resistance (HOMA-IR), thyroid-stimulating hormone (TSH), FT4, FT3, thyroid peroxidase antibody (TPOAb), thyroglobulin antibody (TGAb), serum uric acid (UA), ...
Source: Endocrine Journal - Category: Endocrinology Tags: Endocr J Source Type: research
Authors: Oshagbemi OA, Franssen FME, van Kraaij S, Braeken DCW, Wouters EFM, Maitland-van der Zee AH, Driessen JHM, de Vries F Abstract Although recently introduced in the pharmacological treatment algorithm of chronic obstructive pulmonary disease (COPD), there is a need for more data supporting the use of blood eosinophil counts as a biomarker to guide inhaled corticosteroids (ICS) therapy. The aim of this study was to evaluate the risk of moderate and/or severe exacerbations and all-cause mortality in a large primary care population after withdrawal of ICS compared to continued users stratified by elevated blood...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - Category: Respiratory Medicine Tags: COPD Source Type: research
This study involved patients from the North-East Indian population, where the numbers of reported cases are increasing rapidly and alarmingly. Oxidative stress, based on 8-OH-dG levels, was found to be significantly higher in gallbladder anomalies (cholelithiasis [CL] and cholecystitis [CS]) and GBC at the plasma and DNA level, and was associated with GBC severity. The expressions of key BER pathway genes were downregulated in gallbladder anomalies and GBC compared to controls, and in GBC compared to both non-neoplastic controls and gallbladder anomalies. Expression of XRCC1 and hOGG1 was significantly associated with both...
Source: Free Radical Research - Category: Research Tags: Free Radic Res Source Type: research
Authors: Nishiyama A, Wakabayashi H, Nishioka S, Nagano A, Momosaki R Abstract Our aim was to clarify the nutritional status and energy intake needed for activities of daily living (ADL) improvement among convalescent stroke patients. This retrospective cohort study of stroke patients used data from the Japan Rehabilitation Nutrition Database. Mean energy intake per ideal body weight was 26 kcal/kg/day at 1 week after hospitalization. Patients were divided into two groups according to energy intake: ≥26 kcal/kg/day (high) and
Source: Neurologia Medico-Chirurgica - Category: Neurosurgery Tags: Neurol Med Chir (Tokyo) Source Type: research
Publication date: Available online 24 May 2019Source: Molecular Phylogenetics and EvolutionAuthor(s): Giuliana Allegrucci, Valerio SbordoniAbstractWe investigated the molecular phylogenetic divergence and historical biogeography of cave crickets belonging to the family Rhaphidophoridae (Orthoptera, Ensifera). We used taxa representative of most of the regions embraced by the family, considering samples of Macropathinae from Gondwana land (i.e., Tasmania, Australia, New Zealand, South Africa, and South America); Aemodogryllinae and Rhaphidophorinae from Southern-eastern Asia (i.e., India, Bhutan, China, Philippines and the ...
Source: Molecular Phylogenetics and Evolution - Category: Molecular Biology Source Type: research
Publication date: Available online 24 May 2019Source: Life SciencesAuthor(s): Feng-Ling Yu, Jun-Wen Wu, He ZhuAbstractAimAcetaminophen (APAP) overdose is the most frequent cause of drug-induced liver damage. Magnolia officinalis is a traditional hepatoprotective Chinese medicine and Honokiol (HO) is the major active constituent. The present study was to investigate the effect of HO on APAP-induced hepatotoxicity and related mechanisms.Main methodsFour groups of mice were subjected to treatment as vehicle, APAP, APAP + HO and APAP + HO + NRF2 inhibitor. The morphological and biochemical assessments were used to ...
Source: Life Sciences - Category: Biology Source Type: research
Publication date: Available online 24 May 2019Source: Life SciencesAuthor(s): Andréa A.S. Mendonça, Reggiani V. Gonçalves, Thaiany G. Souza-Silva, Izabel R.S.C. Maldonado, André Talvani, Antônio J. Natali, Rômulo D. NovaesAbstractWhen administered alone, preinfection exercise training and benznidazole-based chemotherapy induce cardioprotection in Chagas disease. However, the effect of concomitant exercise and benznidazole treatment is unknown. We investigated whether exercise and specific chemotherapy could interact to modulate parasitemia, inflammation, redox status and heart damage...
Source: Life Sciences - Category: Biology Source Type: research
Publication date: Available online 24 May 2019Source: Fish &Shellfish ImmunologyAuthor(s): Hongxing Liu, Ting Ye, Tan Kar Soon, Hongkuan Zhang, Dewei Cheng, Shengkang Li, Hongyu Ma, Huaiping ZhengAbstractStocking density is a crucial factor in shellfish aquaculture that affects overall growth performance and health status. Present study analyzes the effects of stocking densities on growth, survival and hemolymph immune status of noble scallop Chlamys nobilis. The scallops with the same size were separately placed in the lantern cages (10 layers per cage) using high stocking density (500 scallops per cage) and low stock...
Source: Fish and Shellfish Immunology - Category: Biology Source Type: research
More News: Abelcet | Academia | Acetic Acid | Acute Leukemia | African Health | Allergy & Immunology | Anthrax | Antidoxidants | Aspergillus | Biology | Biotechnology | Cancer & Oncology | Candida | Carcinoma | Chemistry | China Health | Chloride | Cipro | Ciprofloxacin | Clinical Trials | Copper | Databases & Libraries | Egypt Health | Enterococcus | Environmental Health | Gastroenteritis | Genetics | Germany Health | Ghana Health | Grants | Guinea Health | Hepatocellular Carcinoma | HIV-Leishmania Co-infection | Infectious Diseases | Japan Health | Kidney Transplant | Leukemia | Liver Cancer | Manganese | Men | Microbiology | Middle East Health | Molecular Biology | MRSA | Nystatin | Parasitic Diseases | Parasitology | Potassium | Reproduction Medicine | Science | Scotland Health | Sodium Chloride | South Korea Health | Soya | Staphylococcus Aureus | Study | Superbugs | Toxicology | UK Health | Urology & Nephrology | USA Health | Zinc