BioGX Launches 5 new CE Mark IVD Tests, Expands Sexual Health Panels on the BD MAX(TM)
AMSTERDAM, Oct. 23, 2018 -- (Healthcare Sales & Marketing Network) -- BioGX B.V., recently released five (5) new sexual health CE Mark IVD products on the BD MAXTM automated sample-to-result platform, making the BD MAXTM one of the most comprehensive sexu... Diagnostics, Regulatory, Product Launch BioGX, Candida, HSV, HSVHD (Source: HSMN NewsFeed)
Source: HSMN NewsFeed - October 23, 2018 Category: Pharmaceuticals Source Type: news

DNGR-1 in dendritic cells limits tissue damage by dampening neutrophil recruitment
Host injury triggers feedback mechanisms that limit tissue damage. Conventional type 1 dendritic cells (cDC1s) express dendritic cell natural killer lectin group receptor-1 (DNGR-1), encoded by the gene Clec9a, which senses tissue damage and favors cross-presentation of dead-cell material to CD8+ T cells. Here we find that DNGR-1 additionally reduces host-damaging inflammatory responses induced by sterile and infectious tissue injury in mice. DNGR-1 deficiency leads to exacerbated caerulein-induced necrotizing pancreatitis and increased pathology during systemic Candida albicans infection without affecting fungal burden. T...
Source: ScienceNOW - October 18, 2018 Category: Science Authors: del Fresno, C., Saz-Leal, P., Enamorado, M., Wculek, S. K., Martinez-Cano, S., Blanco-Menendez, N., Schulz, O., Schulz, O., Gallizioli, M., Miro-Mur, F., Cano, E., Planas, A., Sancho, D. Tags: Immunology reports Source Type: news

Caprylic acid, a nutrient found in coconut oil, kills persistent Candida biofilms
(Natural News) Caprylic acid, a natural compound found in abundance in coconut oil, has been observed to penetrate and eradicate persistent Candida biofilms. A recent peer-reviewed study published in Frontiers of Microbiology concluded that a combination of caprylic acid and pectic acid (a water-soluble fiber found in most fruits and vegetables) completely eliminated pathogenic biofilms... (Source: NaturalNews.com)
Source: NaturalNews.com - October 17, 2018 Category: Consumer Health News Source Type: news

Arid5a makes the IL-17A/F-responsive pathway less arid
The cytokine interleukin-17A/F (IL-17A/F) not only protects the skin and mucosae against Candida albicans infection in mice and humans but also promotes autoimmunity and autoinflammation in mice. In this issue of Science Signaling, Amatya et al. report that the RNA binding protein Arid5a promotes responses to IL-17A/F through multiple mechanisms. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - October 9, 2018 Category: Science Authors: Puel, A., Casanova, J.-L. Tags: STKE Focus Source Type: news

Medical News Today: What to know about esophageal thrush
Esophageal thrush is a fungal infection of the food pipe. It occurs when a naturally occurring fungus called Candida grows out of control. Esophageal thrush is a serious condition, causing pain and difficulty swallowing. It may also spread to other parts of the body. Learn more about esophageal thrush here. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - October 8, 2018 Category: Consumer Health News Tags: Ear, Nose and Throat Source Type: news

C auris Outbreak Tied to Skin Surface Temperature Probe C auris Outbreak Tied to Skin Surface Temperature Probe
Environmental transmission of multidrug-resistant Candida auris infection in a neurosciences intensive care unit in Britain was traced to reusable skin surface axillary temperature probes.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - October 4, 2018 Category: Consumer Health News Tags: Infectious Diseases News Source Type: news

Hospital's Fungal Outbreak Blamed on Reusable Thermometers
(MedPage Today) -- Candida auris superbugs found on skin-surface axillary probes (Source: MedPage Today Infectious Disease)
Source: MedPage Today Infectious Disease - October 3, 2018 Category: Infectious Diseases Source Type: news

Several different essential oils scientifically confirmed to combat fungal infections
(Natural News) Normally, the polymorphic fungi Candida albicans is not harmful to the body unless certain conditions cause it to become virulent. Researchers from Southwest College of Naturopathic Medicine, Arizona State University, and Enerpathic Technologies discovered that different botanical tinctures and essential oils prevent C. albicans from progressing into its more virulent forms. Essential oils and botanical... (Source: NaturalNews.com)
Source: NaturalNews.com - September 29, 2018 Category: Consumer Health News Source Type: news

Large Cluster of Fluconazole-Resistant Candida auris Found Large Cluster of Fluconazole-Resistant Candida auris Found
Candida auris infections resistant to fluconazole (and sometimes to amphotericin) were identified in 20 hospitals and nursing homes, according to the CDC.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - September 17, 2018 Category: Consumer Health News Tags: Infectious Diseases News Source Type: news

Candida overgrowth: Facts and tips to manage it
(Natural News) Candida is a fungus, or a form of yeast, that naturally occurs in the human body. It can be found in the mouth and the intestines. It is normal to have this fungus in your body; however, the fungus may also invade your body. This is known as candida overgrowth, and it may have negative... (Source: NaturalNews.com)
Source: NaturalNews.com - September 13, 2018 Category: Consumer Health News Source Type: news

How to treat fungal and yeast infections naturally
(Natural News) Candidiasis is a fungal infection caused by an overgrowth of Candida, a type of yeast, especially Candida albicans. This yeast typically grows in the gastrointestinal tract. Although it generally causes no harm to healthy people, it is actually health-threatening in people with weak immune systems. According to studies, a lack of beneficial bacteria... (Source: NaturalNews.com)
Source: NaturalNews.com - September 6, 2018 Category: Consumer Health News Source Type: news

Everything you need to know about candida overgrowth
(Natural News) You may never have heard of the term “candida overgrowth,” but that doesn’t mean that you haven’t been affected by it. In fact, the combination of a standard Western diet and a lifetime of antibiotic consumption have left most of us battling this condition without even being aware of it. A quick glance... (Source: NaturalNews.com)
Source: NaturalNews.com - August 30, 2018 Category: Consumer Health News Source Type: news

32 Children ’s Medicines Recalled For Potential ‘ Microbial Contamination ’
(CBS Local) – King Bio is voluntarily recalling 32 children’s medicines because of potential “microbial contamination,” the company said in a statement on Wednesday. The medicines, which include those meant to relieve common illnesses including fever, cough, flu, tummy aches, nosebleeds, and earaches, were sold nationwide. According to the company, “the use of drugs products with microbial contamination could potentially result in increased infections that may require medical intervention, and could result in infections that could be life threatening to certain individuals.” No...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - August 23, 2018 Category: Consumer Health News Authors: Health – CBS Boston Tags: Health News children's medication FDA Local TV Recall talkers Source Type: news

Recall: King Bio Kids Products For Contamination
It is the second time in as many months that the company has issued a recall over potential contamination. In July, it recalled four lots of teething liquids, lymph detox, and candida products after an FDA inspection found them to be contaminated with bacteria. (Source: WebMD Health)
Source: WebMD Health - August 23, 2018 Category: Consumer Health News Source Type: news

Medical News Today: About Candida albicans: Natural yeast and problematic infections
Candida albicans is the most common yeast that we live with. It ’s found naturally on our skin and in certain parts of our bodies. We explain what Candida albicans is and 11 scenarios when its overgrowth or presence means infection. Learn about other Candida infections and how they’re diagnosed, too. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - August 9, 2018 Category: Consumer Health News Tags: Infectious Diseases / Bacteria / Viruses Source Type: news

Is this the next superbug? Understanding drug-resistant candida and why antibiotics don't work
(Natural News) Move over, superbug: The next drug-resistant pathogen could be a fungus that already calls our body home. In a study published in The Journal of Infectious Diseases last year, researchers noted an uptick in reports of invasive Candida infections that are resistant to antifungal agents. The article, which discussed the current trends in multidrug resistance, revealed that... (Source: NaturalNews.com)
Source: NaturalNews.com - July 29, 2018 Category: Consumer Health News Source Type: news

Candida auris and non-albicans biofilms
Conference abstracts (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - July 23, 2018 Category: Respiratory Medicine Authors: BethBradshaw Source Type: news

King Bio Issues Voluntary Nationwide Recall of Aquaflora Candida HP9, Lymph Detox, and Baby Teething Liquids Due to Microbial Contamination
King Bio is voluntarily recalling four lots of Aquaflora Candida HP9, Lymph Detox, and Baby Teething liquids to the consumer level. During a routine inspection by the U.S. Food and Drug Administration, the products were found to contain microbial contaminants Pseudomonas Brenneri, Pseudomonas Fluroescens and Burkholderia Multivorans. (Source: Food and Drug Administration)
Source: Food and Drug Administration - July 20, 2018 Category: Food Science Source Type: news

Candida albicans: Progress in the understanding of the mechanisms of genetic diversification in a major fungal pathogen of humans
(Institut Pasteur) Candida albicans is a fungal species causing infection in humans. A team of scientists decided to sequence and analyze the genomes of 182 strains of C. albicans from around the world. They confirmed the clonal reproduction of this human pathogen but also showed that parasexual reproduction, previously only observed in a laboratory setting, contributes to the genetic diversity of C. albicans and therefore also to its ability to adapt to new environments and rid itself of deleterious mutations. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - July 9, 2018 Category: International Medicine & Public Health Source Type: news

Do we need to adopt antifungal stewardship programmes
This journal article concludes that the presence of a multidisciplinary team, including an infection control specialist and a clinical pharmacist, would limit the prescription of advanced antifungal agents as empirical therapy. The authors state that this team would control the de-escalation process —where applicable—leading to a reduction in costs and, probably, a decrease in the emergence of resistant Candida species. These facts contribute to the broader discussion on the adoption of antifungal stewardship programmes. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - July 4, 2018 Category: Consumer Health News Source Type: news

Which herbal medicines demonstrate the best anti-Candida activity?
(Natural News) Scientists highlight extracts from Portulaca oleracea and Lawsonia inermis to have anti-Candida properties. The study, published in the journal BMC Complementary and Alternative Medicine, looked into seven plant extracts to find which ones were most potent against Candida albicans while remaining safe for human use. Candida albicans is one of the leading causes... (Source: NaturalNews.com)
Source: NaturalNews.com - July 4, 2018 Category: Consumer Health News Source Type: news

5 Myths about Bipolar Disorder That Boost Stigma
When therapist Colleen King was 19 years old, a psychiatrist told her that because of her family history—her father and brother having bipolar disorder—she shouldn’t have children. Today, King’s clients regularly tell her that people have told them they shouldn’t or can’t have loving relationships. Sadly, these are just two of the many myths about bipolar disorder. Myths that needlessly boost stigma, and, as King noted, deny individuals with bipolar disorder love and connection. Bipolar disorder is a difficult illness, which can create challenges. But kids and healthy, happy relationship...
Source: Psych Central - July 1, 2018 Category: Psychiatry Authors: Margarita Tartakovsky, M.S. Tags: Bipolar Disorders Family General Relationships & Love Self-Help Stigma bipolar disorder and relationships bipolar disorder stereotypes bipolar disorder stigma mania Manic Symptoms Mental Health Stigma myths about bipolar disorder Source Type: news

The antimicrobial properties of essential oils found to be effective against drug-resistant Candida
(Natural News) As antifungal drug resistance grows increasingly common, a number of scientists have turned to plant-derived essential oils for a solution. To that end, researchers from the Flanders Institute for Biotechnology (VIB) have developed a new screening method to identify the antimicrobial qualities of these volatile substances. They dubbed their method the vapor-phase-mediated susceptibility (VMS)... (Source: NaturalNews.com)
Source: NaturalNews.com - June 13, 2018 Category: Consumer Health News Source Type: news

Armpit Thermometers Helped Spread Fungus at UK Hospital
Armpit thermometers led to a large outbreak of drug-resistant Candida auris fungus in the United Kingdom. (Source: WebMD Health)
Source: WebMD Health - May 4, 2018 Category: Consumer Health News Source Type: news

Armpit Thermometers Helped Spread Dangerous Fungus at UK Hospital
FRIDAY, May 4, 2018 -- Armpit thermometers led to a large outbreak of drug-resistant Candida auris fungus in the United Kingdom, researchers say. The outbreak occurred in Oxford University Hospitals'neurosciences intensive care unit. The culprit:... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - May 4, 2018 Category: General Medicine Source Type: news

Monash study exposes key tactic used by deadly fungus
(Monash University) Associate Professor Ana Traven, in collaboration with the Naderer lab, has found that a lethal fungus destroys the immune cell that would ordinarily kill it, by stealing its source of nutrients. Candida albicans is a microscopic fungus commonly found in the body but which can become a dangerous infection in vulnerable hospital patients. The study demonstrated that the fungus competes with disease-fighting macrophages by rapidly consuming glucose and causing the macrophages to die. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - May 1, 2018 Category: Biology Source Type: news

FDA Clears First Test for Emerging Pathogen Candida auris FDA Clears First Test for Emerging Pathogen Candida auris
The Bruker Maldi Biotyper CA system can reliably identify C auris 100% of the time.FDA Approvals (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - April 23, 2018 Category: Consumer Health News Tags: Infectious Diseases News Alert Source Type: news

Sharing thermometers in hospital spreads Japanese fungus in wards
Shared thermometers used to measure armpit temperature are a likely source of Candida auris - a dangerous Japanese fungus which has swept through British hospital wards, experts believe. (Source: the Mail online | Health)
Source: the Mail online | Health - April 21, 2018 Category: Consumer Health News Source Type: news

FDA authorizes new use of test, first to identify the emerging pathogen < i > Candida auris < /i >
FDA authorized the first test to identify the emerging pathogen Candida auris, which can cause serious infections in hospitalized patients. (Source: Food and Drug Administration)
Source: Food and Drug Administration - April 20, 2018 Category: American Health Source Type: news

Large Candida auris outbreak linked to multi-use thermometers in UK ICU
(European Society of Clinical Microbiology and Infectious Diseases) Outbreaks of the fungal pathogen Candida auris in healthcare settings, particularly in intensive care units (ICUs), may be linked to multi-use patient equipment, such as thermometers, according to research presented at the 28th European Congress of Clinical Microbiology and Infectious Diseases. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - April 20, 2018 Category: Biology Source Type: news

Notes from the Field: Surveillance for Candida auris — Colombia, September 2016–May 2017
(Source: CDC Morbidity and Mortality Weekly Report)
Source: CDC Morbidity and Mortality Weekly Report - April 19, 2018 Category: American Health Source Type: news

Activity of Ceragenin CSA-131 against Candida Auris
Published Research Shows Ceragenin CSA-131 ’s Potent Efficacy against Candidaauris, a New Serious Global Health ThreatDUBLIN, OHIO – April 5, 2018 – N8 Medical, LLC today announced a peer-reviewed publication in The Journal ofAntimicrobial Chemotherapy with U.S. Centers for Disease Control and Prevention (CDC) co-authors of promisingefficacy data regarding the activity of ceragenin CSA-131 against 100 strains of Candida auris (C. auris) collected fromaround the world. (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - April 9, 2018 Category: Respiratory Medicine Authors: ROrritt Source Type: news

Microscopic revelations point to new blood infection therapies
(University of Calgary) Researchers at the University of Calgary's Cumming School of Medicine (CSM) have for the first time been able to observe -- live and in real-time -- how the human body responds to often lethal fungal blood infections in the lung. In the study, the fungal infection Candida albicans was introduced to mice or human models of the lung vasculature and as blood was pumped over that system, researchers recorded what happened using highly sophisticated microscopes. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - April 4, 2018 Category: International Medicine & Public Health Source Type: news

T2 Biosystems touts results from 4 studies of its T2Dx diagnostics system
T2 Biosystems this week released results from four studies of its T2Dx blood diagnostics system designed to detect pathogens that cause sepsis, touting clinical and performance advantages when compared to traditional blood cultures. The four studies were published in the Journal of Antimicrobial Chemotherapy, the Lexington, Mass.-based company said. A study conducted at Rome’s Gemelli Hospital examined the use of the T2Bacteria panel on the T2Dx, and found that positive results were produced 4.5 times faster at 5.5 hours versus 25 hours with a standard blood culture. Negative results on the T2Bacteria panel were...
Source: Mass Device - March 30, 2018 Category: Medical Devices Authors: Fink Densford Tags: Clinical Trials Diagnostics T2 Biosystems Inc. Source Type: news

Amplyx Pharmaceuticals Receives Fourth "Qualified Infectious Disease Product" (QIDP) Designation from the FDA for APX001
QIDP Designation Granted for Treatment of Cryptococcosis Provides Priority Review, Fast-Track Status and Five Additional Years of Market Exclusivity SAN DIEGO, March 19, 2018 -- (Healthcare Sales & Marketing Network) -- Amplyx Pharmaceuticals, a compan... Biopharmaceuticals, FDA Amplyx Pharmaceuticals, Candida, Aspergillus (Source: HSMN NewsFeed)
Source: HSMN NewsFeed - March 19, 2018 Category: Pharmaceuticals Source Type: news

Plant-derived volatiles may serve as future antifungals
(VIB (the Flanders Institute for Biotechnology)) A research team at the VIB-KU Leuven Center for Microbiology has developed a novel screening method to identify antimicrobial properties of volatile substances. With this assay, they tested the vapour-phase-mediated activity of 175 essential oils (EOs) and 37 EO components. Approximately half of them proved active against the most drug-resistant type of Candida. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - March 9, 2018 Category: Biology Source Type: news

T2 Biosystems tops The Street with Q4, 2017 earnings
T2 Biosystems Inc. (NSDQ:TTOO) today reported fourth quarter and full year 2017 earnings that topped expectations on Wall Street. The Lexington, Mass.-based company reported sales of $1.7 million for its fourth quarter, up 87% when compared with the same quarter least year. Costs for the quarter, excluding the cost of product revenue, were $9.8 million, down 16% over the previous years costs and expenses. Sales expectations for the fourth quarter on Wall Street were $1.3 million, which the company handily topped. For the full year, T2 Biosystems reported revenue of $4.7 million, up 15% from the previous year. Product ...
Source: Mass Device - March 6, 2018 Category: Medical Devices Authors: Fink Densford Tags: Business/Financial News MassDevice Earnings Roundup Wall Street Beat T2 Biosystems Inc. Source Type: news

Is a high sugar diet damaging your gut? Six signs you could have candida overgrowth
CANDIDA is a yeast that naturally exists in the mouth, gut and vagina. It isn ’t a problem until it grows and overpopulates your digestive system, which can a number of symptoms. Here are six signs you could have candida overgrowth syndrome. (Source: Daily Express - Health)
Source: Daily Express - Health - February 16, 2018 Category: Consumer Health News Source Type: news

Could a Rare, Deadly ‘ Superbug ’ Fungus Be Gaining a Foothold? Could a Rare, Deadly ‘ Superbug ’ Fungus Be Gaining a Foothold?
The Centers for Disease Control and Prevention says the number of confirmed cases of Candida auris in the U.S. has climbed from seven in 2016 to at least 200.Kaiser Health News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - February 14, 2018 Category: Consumer Health News Tags: Infectious Diseases News Source Type: news

WPI Biologist Reeta Rao elected a fellow of the American Academy of Microbiology
(Worcester Polytechnic Institute) Reeta Rao, a biologist at Worcester Polytechnic Institute (WPI), has been elected a fellow of the American Academy of Microbiology. She studies the biology of fungal diseases, particularly those caused by Candida, a species of fungi responsible for oral thrush, ear infections, and vaginitis, but which is also the leading cause of serious illnesses among hospitalized patients. Treating these life-threatening infections, which have a 30-50 percent mortality rate, costs more than $1 billion annually. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - January 31, 2018 Category: International Medicine & Public Health Source Type: news

Emerging Multidrug-Resistant Candida Species Emerging Multidrug-Resistant Candida Species
Infections caused by multidrug-resistant Candida species are on the rise. How are these infections best treated?Current Opinion in Infectious Diseases (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - January 25, 2018 Category: Consumer Health News Tags: Infectious Diseases Journal Article Source Type: news

New antifungal provides hope in fight against superbugs
(Case Western Reserve University) Microscopic yeast have been wreaking havoc in hospitals around the world -- creeping into catheters, ventilator tubes, and IV lines -- and causing deadly invasive infection. One culprit species, Candida auris, is resistant to many antifungals, meaning once a person is infected, there are limited treatment options. But in a recent Antimicrobial Agents and Chemotherapy study, researchers confirmed a new drug compound kills drug-resistant C. auris, both in the laboratory and in a mouse model that mimics human infection. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - January 11, 2018 Category: Infectious Diseases Source Type: news

PROBIOTICS as medicine: Proper yeast balance in the gut microbiome found to help schizophrenia sufferers
(Natural News) Schizophrenia is a psychiatric disorder wherein a person displays abnormal social behavior and a failure to differentiate between reality and fantasy. More often than not, schizophrenic individuals have yeast infections, but researchers still do not know why. These yeast infections, caused by Candida albicans found in human gut flora, do not cause mental... (Source: NaturalNews.com)
Source: NaturalNews.com - December 10, 2017 Category: Consumer Health News Source Type: news

The mouth is a first responder for the immune system: New study provides clues for how the body defends against oral invaders
(Natural News) New research has identified how the mouth acts as a trigger for the immune system’s defenses to kick in once the fungus Candida albicans – which causes oral thrush –  has invaded the body. The international team, led by the researchers at the University of Pittsburgh School of Medicine, studied how microbes inside the mouth called commensals,... (Source: NaturalNews.com)
Source: NaturalNews.com - December 5, 2017 Category: Consumer Health News Source Type: news

Preclinical Evaluation of the Stability, Safety and Efficacy of CD101, a Novel Echinocandin
Fungal infections pose a significant public health burden with high morbidity and mortality. CD101 is a novel echinocandin under development for the treatment and prevention of systemic Candida infections. Preclinical studies were conducted to evaluate the metabolic stability, plasma protein binding, pharmacokinetics, toxicity, and efficacy of CD101 at various dose levels. CD101 was stable to biotransformation in rat/monkey/human liver microsomes and rat/monkey/dog/human hepatocytes. (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - November 1, 2017 Category: Respiratory Medicine Authors: BethBradshaw Source Type: news

Novel Macrocyclic Amidinoureas: Potent Non-Azole Antifungals Active against Wild-Type and Resistant Candida Species
Novelmacrocyclic amidinourea derivatives 11, 18, and 25 were synthesized and evaluated as antifungal agentsagainstwild-type and fluconazoleresistantCandidaspecies. (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - October 20, 2017 Category: Respiratory Medicine Authors: BethBradshaw Source Type: news

Enfumafungin derivative MK-3118 shows increased in vitro potency against clinical echinocandin-resistant Candida Species and Aspergillus species isolates.
MK-3118 is as an orally active new antifungal in the early stage of clinical development that inhibits the biosynthesis of β-(1,3)-glucan. We evaluated the invitro activity of this compound against wild-type and echinocandin-resistant (ER) isolates containing mutations in the FKS gene(s) of Candida spp. and Aspergillus spp.MK-3118 demonstrated enhanced efficacy for most C. albicans and C. (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - October 20, 2017 Category: Respiratory Medicine Authors: BethBradshaw Source Type: news

Antifungal activity of statins against Aspergillus species
The cholesterol-lowering agents known as statins have in vitro activities against human pathogenic fungi, such as Candida species, Cryptococcus neoformans, and Zygomycetes. Synergy between statins and azoles against these fungi has also been reported. We evaluated the in vitro activities of two statins, lovastatin andsimvastatin, alone and in combination with azoles and amphotericin B, against clinical isolates ofAspergillus spp. (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - October 11, 2017 Category: Respiratory Medicine Authors: BethBradshaw Source Type: news

Growth inhibition of Candida species and Aspergillus fumigatus by statins.
Statins are a class of drugs widely used for lowering high cholesterol levels through their action on 3-hydroxy-3-methylglutaryl-CoA reductase, a key enzyme in the synthesis of cholesterol. We studied the effects of two major statins,simvastatin and atorvastatin, on five Candida species andAspergillus fumigatus. The statins strongly inhibited the growth of all species, except Candida krusei. Supplementation of Candida albicans and A. (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - October 11, 2017 Category: Respiratory Medicine Authors: BethBradshaw Source Type: news

Antifungal spectrum, in vivo efficacy, and structure-activity relationship of ilicicolin H
Ilicicolin H is a polyketide-nonribosomal peptide synthase (NRPS)-natural product isolated from Gliocadium roseum, which exhibits potent and broad spectrum antifungal activity, with sub- μg/mL MICs against Candida spp., Aspergillus fumigatus, and Cryptococcus spp. It showed a novel mode of action, potent inhibition (IC50 = 2-3 ng/mL) of the mitochondrial cytochrome bc1 reductase, and over 1000-fold selectivity relative to rat liver cytochrome bc1 reductase. (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - October 11, 2017 Category: Respiratory Medicine Authors: BethBradshaw Source Type: news