Towards a Better Understanding of the Role of the Gut Microbiome in Alzheimer's Disease
This article summarizes research presented at the virtual symposium and workshop, "New Approaches for Understanding the Potential Role of Microbes in Alzheimer's Disease." The objective of these events was to review the evidence base and catalyze research to address knowledge gaps in the hypothesis that infections or microbes play some causative role in the development or progression of Alzheimer's disease. Alzheimer's disease is a complex disease; this symposium was rooted in an understanding that its pathogenesis could be triggered by both microbe-dependent and microbe-independent pathways and the two are not mutually ex...
Source: Fight Aging! - March 15, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, November 20th 2023
In this study, we attempted to further explain the role, exact mechanism and target of ICA in treating AD from the ferroptosis perspective. We found that ICA could improve the neurobehavioral, memory, and motor abilities of AD mice. It could lower the ferroptosis level and enhance the resistance to oxidative stress. After inhibition of MDM2, ICA could no longer improve the cognitive ability of AD mice, nor could it further inhibit ferroptosis. Network pharmacological analysis revealed that MDM2 might be the target of ICA action.
« Back to Top
Particulate Air Pollution and Its Effects on the Mechan...
Source: Fight Aging! - November 19, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
The Brain Microbiome Theory of Alzheimer's Disease
The amyloid cascade hypothesis of Alzheimer's disease suggests that the disease arises from misfolding and aggregation of amyloid-β, which grows to disrupts brain metabolism to produce inflammation and tau aggregation in later stages of the condition. While the amyloid cascade hypothesis remains the dominant view of the causes of Alzheimer's disease, there are other views. For example, that persistent infection leads directly to a runaway feedback loop of chronic inflammation and tau aggregation. In this view, amyloid-β aggregation is a side-effect, given that amyloid-β appears to be an anti-microbial peptide, a part of...
Source: Fight Aging! - November 17, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Etched Nanopillars Kill Bacteria, Fungi on Titanium Implants
Researchers at RMIT in Australia have developed a drug-free approach to kill bacteria and fungi that can infect surfaces on medical implants. Such pathogens can cause serious and difficult-to-treat infections around medical implants, sometimes requiring the removal of the implant. In addition, many microbes are increasingly resistant to common antibiotics, highlighting the need for drug-free approaches. This new technique is inspired by the nanopillars present on dragonfly wings, which can skewer microbial cells, killing them. The researchers used a relatively simple plasma etching technique to create such nanopillars on t...
Source: Medgadget - September 20, 2023 Category: Medical Devices Authors: Conn Hastings Tags: Materials Medicine Public Health Candida RMIT Source Type: blogs
Choice Could Depoliticize Battles over Schools
David BoazThe Washington Postreports—yetagain—that conservative parent/activists are running for and often winning seats on local school boards in order to change school policies on virtual learning, masks, and the kinds of books in school libraries. Regardless of what one thinks about the specific policy changes that school board candida tes may propose, the whole issue illustrates the problem of public schooling: that there must be one solution for a whole school district, a whole state, or even the whole country. Over the years parents, taxpayers, and other voters havedisagreed over many things: evoluti...
Source: Cato-at-liberty - January 24, 2022 Category: American Health Authors: David Boaz Source Type: blogs
Simple Color Change Test Identifies Wound Infections
Researchers at the University of Bath in the UK, along with outside collaborators, have developed a simple color change test that rapidly indicates whether a wound is infected with harmful bacteria. The test works by detecting virulence factors released by the bacteria, which prompt a simple color change in a solution. The test could help clinicians to determine whether to prescribe antibiotics, and may help to avoid unnecessary prescribing. As the test can be administered at the point of care, and does not require expensive and time-consuming laboratory analysis, it may be very useful in low-resource or remote regions.
...
Source: Medgadget - November 5, 2021 Category: Medical Devices Authors: Conn Hastings Tags: Dermatology Diagnostics Materials Plastic Surgery uniofbath wound care Source Type: blogs
Mural endocarditis
Vegetations in infective endocarditis are usually situated on the valves. If they are located on the walls of the cardiac chambers, it is known as mural endocarditis [1]. When mural endocarditis occurs without any cardiac structural abnormalities like ventricular septal defects, it is called primary mural endocarditis [2]. Primary mural endocarditis is extremely rare.
Left atrial mural endocarditis usually occurs due to the jet lesion of mitral regurgitation [1,3]. Left atrial mural endocarditis is usually picked up by trans esophageal echocardiography. Vegetations are mostly located just distal to the mitral orifice betw...
Source: Cardiophile MD - October 31, 2021 Category: Cardiology Authors: Prof. Dr. Johnson Francis Tags: General Cardiology Source Type: blogs
Answer to Case 639
Answer to Case of the Week 639: Microsporidia spores. As many of you noted, the differential diagnosis includesToxoplasma gondiitachyzoites. Here are some of the key morphologic features:Location in the cornea. [T. gondiiis usually found in the posterior chamber of the eye (e.g., retina)]Small oval shape with well-defined contours on H&E:Unfortunately,T. gondiitachyzoites are much less defined on H&E - they can be very difficult to see. They often don ' t even have a nice crescent shape like we seen on Giemsa-stained air-dried impression smears. They often just look like little blobs in tissue.Strong Gram...
Source: Creepy Dreadful Wonderful Parasites - May 16, 2021 Category: Parasitology Source Type: blogs
Should you use probiotics for your vagina?
You know probiotics can be good for your gut, but does your vagina need one too? You might think so, based on probiotic marketing these days. Probiotics are in everything from drinks to pills and powders, and in many cases, are being promoted as a means of improving your vaginal health.
Women seem to be listening, says Dr. Caroline Mitchell, assistant professor of obstetrics, gynecology, and reproductive biology at Harvard Medical School. Vaginal probiotic supplements are hugely popular. This includes both probiotic pills and suppository capsules that are inserted into the vagina using an applicator.
But evidence of effect...
Source: Harvard Health Blog - December 27, 2019 Category: Consumer Health News Authors: Kelly Bilodeau Tags: Health Sexual Conditions Vitamins and supplements Women's Health Source Type: blogs
Turmeric: Why does it work?
The post Turmeric: Why does it work? appeared first on Dr. William Davis. (Source: Wheat Belly Blog)
Source: Wheat Belly Blog - November 4, 2019 Category: Cardiology Authors: Dr. Davis Tags: Wheat Belly Lifestyle anti-fungal candida fungi Inflammation microbiota sibs small intestinal bacterial undoctored Source Type: blogs
” I can ’ t eat beans! ”
The post ” I can’t eat beans!” appeared first on Dr. William Davis. (Source: Wheat Belly Blog)
Source: Wheat Belly Blog - October 12, 2019 Category: Cardiology Authors: Dr. Davis Tags: Wheat Belly Lifestyle bowel flora candida food intolerances fungal overgrowth prebiotic probiotic sibo sifo small intestinal bacterial overgrowth undoctored Source Type: blogs
What to know about C. auris, the deadly fungus affecting our sickest patients
Candida auris (C. auris) is a multidrug-resistant fungus responsible for a rising number of infections and deaths around the world, the origin of which is currently subject to investigation. Spread primarily in the health care setting, it is a growing threat to high-risk patients in hospitals, nursing homes, an d other health care facilities. The CDC estimates […]Find jobs at Careers by KevinMD.com. Search thousands of physician, PA, NP, and CRNA jobs now. Learn more. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - October 7, 2019 Category: General Medicine Authors: < span itemprop="author" > < a href="https://www.kevinmd.com/blog/post-author/gerald-blackburn" rel="tag" > Gerald Blackburn, DO < /a > < /span > Tags: Conditions Infectious Disease Source Type: blogs
Prepubertal Dysuria Not as Simple as a UTI
Prepubertal boys who present to the emergency department with dysuria are uncommon. The adult with burning on urination is assumed to have a sexually transmitted disease, but of course that diagnosis should not be high on your list for boys.In fact, infectious urethritis in children is quite uncommon unless there is premature sexual activity or sexual abuse by an adult. Unfortunately, a variety of noninfectious urethral pathologies may mimic infectious urethritis in children. A urinary tract infection in a prepubertal boy is an infectious cause of dysuria. Those infections, however, rarely present with the isolated symp...
Source: M2E Too! Mellick's Multimedia EduBlog - September 3, 2019 Category: Emergency Medicine Tags: Blog Posts Source Type: blogs
Plain and Simple Ocular Punctal Plug Removal: Part II
Ocular punctal plug removal is a straightforward procedure easily completed in the emergency department. Serious complications from punctal plug insertions are rare but sometimes seen.Left: A punctal plug in the upper lacrimal duct of the right eye, allowing for moisture balance from tear production. Right: The tiny punctal plug after it was removed. Photos by M. Roberts.Punctal plugs are placed in some or all of the lacrimal ducts by an ophthalmologist to treat chronic dry eye, and can be permanent or dissolvable. Plugs typically stay in place for three months or longer. (Am J Ophthalmol. 2007;144[3]:441.) ...
Source: The Procedural Pause - July 1, 2019 Category: Emergency Medicine Tags: Blog Posts Source Type: blogs
