IIG Seminar
Michail Lionakis combines groundbreaking studies of murine candidiasis models with clinical and genomic insight from his stewardship of the world ’ s largest APECED patient cohort to generate radical, transformative discoveries of fungal infection at the intersection of colonization, invasion, and host defense. Dr. Lionakis has achieved many “ firsts ” , including identification of new AIRE and CARD9 mutations, redefinition of disease clinical spectra, and discovery of effective treatment regimens. He leverages his candidiasis mouse models to advance mechanistic insight, including how Card9 deficiency causes CNS-spec...
Source: Videocast - All Events - April 25, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
IIG Seminar: NIH/FDA - Tobias Hohl
All people encounter, inhale, and ingest fungi on a daily basis. Although only several hundred of the estimated five million species of fungi worldwide cause disease in humans, advances in medical technologies and the global AIDS pandemic have dramatically increased our susceptibility to fungal disease. In cancer and bone marrow transplant patients, the filamentous mold Aspergillus fumigatus and the commensal fungus Candida albicans represent significant causes of infection-related morbidity and mortality. At present, no fungal vaccines have been licensed for clinical use, and contemporary antifungal therapies for systemic...
Source: Videocast - All Events - March 3, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
Oh to be seventeen again: IL-17 signaling in fungal immunity and autoimmune disease
Immunology Interest Group Seminar Series
The IL-17 family constitutes a distinct subclass of pro-inflammatory cytokines with unique structures and signaling properties. Signals from IL-17 mediate immunity to extracellular pathogens, particularly the commensal fungus Candida albicans. Conversely, dysregulated IL-17 signal transduction drives pathogenesis in autoimmune conditions, including psoriasis. This talk will discuss both sides of this dual-acting cytokine, from the perspective of IL-17 receptor-induced signal transduction mechanisms.
Biography: Dr. Sarah Gaffen received her BS in Biological Sciences from Carnegie Mel...
Source: Videocast - All Events - February 3, 2017 Category: Journals (General) Tags: Upcoming Events Source Type: video
