Niche-specific microevolution of Candida glabrata (Nakaseomyces glabrata) during an infection
Fungal Genet Biol. 2024 Apr 13:103891. doi: 10.1016/j.fgb.2024.103891. Online ahead of print.ABSTRACTCandida glabrata (Nakaseomyces glabrata) is an emergent and opportunistic fungal pathogen that colonizes and persists in different niches within its human host. In this work, we studied five clinical isolates from one patient (P7), that have a clonal origin, and all of which come from blood cultures except one, P7-3, obtained from a urine culture. We found phenotypic variation such as sensitivity to high temperature, oxidative stress, susceptibility to two classes of antifungal agents, and cell wall porosity. Only isolate P...
Source: Fungal Genetics and Biology - April 15, 2024 Category: Biology Authors: Ana L L ópez-Marmolejo Marco J Hern ández-Chávez Guadalupe Guti érrez-Escobedo M Selene Herrera-Basurto H éctor M Mora-Montes Alejandro De Las Pe ñas Irene Casta ño Source Type: research
Effects of simulated long-term exposure to bottled, neutral pH electrolyzed oxidizing water on the properties of denture base resins
Denture stomatitis can pose serious health risks, especially to older people. Chemical denture cleaning agents must be effective, yet not adversely affect the longevity of removable dentures. Ready-to-use (RTU) neutral pH electrolyzed oxidizing water (EOW) is an effective biocide against Candida albicans biofilms on denture resins, but the effects of daily disinfection with EOW on the physical and mechanical properties of resins have not been established. (Source: Journal of Prosthetic Dentistry)
Source: Journal of Prosthetic Dentistry - April 14, 2024 Category: Dentistry Authors: Chitra Shankar Krishnan, Kai Chun Li, Geoffrey R. Tompkins, Karl M. Lyons, Richard D. Cannon Tags: Research and education Source Type: research
Pickering nanoemulsion loaded with eugenol contributed to the improvement of konjac glucomannan film performance
Int J Biol Macromol. 2024 Apr 11:131495. doi: 10.1016/j.ijbiomac.2024.131495. Online ahead of print.ABSTRACTKonjac glucomannan (KGM) is becoming a very potential food packaging material due to its good film-forming properties and stability. However, KGM film has several shortcomings such as low mechanical strength, strong water absorption, and poor self-antibacterial performance, which limits its application. Therefore, in order to enhance the mechanical and functional properties of KGM film, this study prepared Pickering nanoemulsion loaded with eugenol and added it to the KGM matrix to explore the improvement effect of P...
Source: International Journal of Biological Macromolecules - April 13, 2024 Category: Biochemistry Authors: Hui Wang Dan Yuan Qingran Meng Yunchong Zhang Xingran Kou Qinfei Ke Source Type: research
Preparing and evaluating the anti-microbial effect of < em > Allium jesdianum < /em > mouthwash on some of the most common oral microorganisms
CONCLUSION: Our results showed a promising anti-fungal-anti-bacterial effect of A. jesdianum extract. A. jesdianum extract may be used as an alternative to chemical mouthwashes.PMID:38605791 | PMC:PMC11006033 | DOI:10.4103/jfmpc.jfmpc_855_23 (Source: Primary Care)
Source: Primary Care - April 12, 2024 Category: Primary Care Authors: Fereshteh Golfakhrabadi Donyasadat Mansouri Effat Abbasi Montazeri Anayatollah Salimi Fatemeh Babadi Vahid Rakhshan Source Type: research
Preparing and evaluating the anti-microbial effect of < em > Allium jesdianum < /em > mouthwash on some of the most common oral microorganisms
CONCLUSION: Our results showed a promising anti-fungal-anti-bacterial effect of A. jesdianum extract. A. jesdianum extract may be used as an alternative to chemical mouthwashes.PMID:38605791 | PMC:PMC11006033 | DOI:10.4103/jfmpc.jfmpc_855_23 (Source: Primary Care)
Source: Primary Care - April 12, 2024 Category: Primary Care Authors: Fereshteh Golfakhrabadi Donyasadat Mansouri Effat Abbasi Montazeri Anayatollah Salimi Fatemeh Babadi Vahid Rakhshan Source Type: research
Unveiling the complexity of early childhood caries: < em > Candida albicans < /em > and < em > Streptococcus mutans < /em > cooperative strategies in carbohydrate metabolism and virulence
CONCLUSION: The symbiotic relationship between C. albicans and S. mutans, and their interactions through carbohydrate metabolism and environmental acidification, are key factors in the pathogenesis of ECC. A comprehensive understanding of these mechanisms is crucial for developing effective strategies to manage and treat ECC.PMID:38606339 | PMC:PMC11008315 | DOI:10.1080/20002297.2024.2339161 (Source: Journal of Oral Microbiology)
Source: Journal of Oral Microbiology - April 12, 2024 Category: Microbiology Authors: Pingping Jin Lu Wang Daozhen Chen Yu Chen Source Type: research
Peptide Extract from Red Kidney Beans, < em > Phaseolus vulgaris < /em > (Fabaceae), Shows Promising Antimicrobial, Antibiofilm, and Quorum Sensing Inhibitory Effects
In this study, peptides were extracted from the seeds of Phaseolus vulgaris (Fabaceae), and the antimicrobial activities of the extract were evaluated using microbroth dilution against five different microorganisms. The extract showed antimicrobial activity against all tested organisms with minimum inhibitory concentrations (MIC) of 2.5 mg/mL, except for Candida albicans and Pseudomonas aeruginosa, which had MICs of 1.25 mg/mL. The extract was also bacteriostatic for all tested organisms. The crude peptide extract from Phaseolus vulgaris was further studied for its antibiofilm activity against Pseudomonas aeruginosa, a com...
Source: Cell Research - April 12, 2024 Category: Cytology Authors: Jennifer Tetteh De-Youngster Wereko Brobbey Kofi Junior Osei Azumah Ayamah Michael Konney Laryea Godfred Darko Lawrence Sheringham Borquaye Source Type: research
Preparing and evaluating the anti-microbial effect of < em > Allium jesdianum < /em > mouthwash on some of the most common oral microorganisms
CONCLUSION: Our results showed a promising anti-fungal-anti-bacterial effect of A. jesdianum extract. A. jesdianum extract may be used as an alternative to chemical mouthwashes.PMID:38605791 | PMC:PMC11006033 | DOI:10.4103/jfmpc.jfmpc_855_23 (Source: Primary Care)
Source: Primary Care - April 12, 2024 Category: Primary Care Authors: Fereshteh Golfakhrabadi Donyasadat Mansouri Effat Abbasi Montazeri Anayatollah Salimi Fatemeh Babadi Vahid Rakhshan Source Type: research
Biomimetic and multifunctional nanocomposites for precision fungi theranostics
Biomaterials. 2024 Apr 4;308:122561. doi: 10.1016/j.biomaterials.2024.122561. Online ahead of print.ABSTRACTFungi infection is a serious threat to public health, but an effective antifungal strategy remains a challenge. Herein, a biomimetic nanocomposite with multifunctionalities, including fungi diagnosis, antifungal adhesion, precise fungi elimination, and cytokine sequestration, is constructed for battling Candida albicans (C. albicans) infection. By screening a range of cells, we find that the polarized macrophage cells have the strongest binding tendency toward C. albicans. Thus, their membranes were exfoliated to cam...
Source: Biomaterials - April 11, 2024 Category: Materials Science Authors: Li Wang Yueyue Gui Kexin Li Wei Tao Chao Li Jin Qiu Jiehua Ma Source Type: research
Enzymatic Synthesis of Copolyesters with the Heteroaromatic Diol 3,4-Bis(hydroxymethyl)furan and Isomeric Dimethyl Furandicarboxylate Substitutions
This study explores the Candida antarctica lipase B (CALB)-catalyzed copolymerization of 3,4-BHMF with furan dicarboxylate isomers and aliphatic diols. The furanic copolyesters (co-FPEs) with higher polymerization degrees are obtained using 2,4-isomer, indicating CALB's preference. Material analysis revealed semicrystalline properties in all synthesized 2,5-FDCA-based co-FPEs, with multiple melting temperatures (Tm) from 53 to 124 °C and a glass-transition temperature (Tg) of 9-10 °C. 2,4-FDCA-based co-FPEs showed multiple Tm from 43 to 61 °C and Tg of -14 to 12 °C; one of them was amorphous. In addition, all co-FPEs s...
Source: Biomacromolecules - April 11, 2024 Category: Biochemistry Authors: Fitrilia Silvianti Dina Maniar Beatriz Agostinho Tijn C de Leeuw Albert Jan Jacob Woortman Jur van Dijken Shanmugam Thiyagarajan Andreia F Sousa Katja Loos Source Type: research
Enzymatic Synthesis of Copolyesters with the Heteroaromatic Diol 3,4-Bis(hydroxymethyl)furan and Isomeric Dimethyl Furandicarboxylate Substitutions
This study explores the Candida antarctica lipase B (CALB)-catalyzed copolymerization of 3,4-BHMF with furan dicarboxylate isomers and aliphatic diols. The furanic copolyesters (co-FPEs) with higher polymerization degrees are obtained using 2,4-isomer, indicating CALB's preference. Material analysis revealed semicrystalline properties in all synthesized 2,5-FDCA-based co-FPEs, with multiple melting temperatures (Tm) from 53 to 124 °C and a glass-transition temperature (Tg) of 9-10 °C. 2,4-FDCA-based co-FPEs showed multiple Tm from 43 to 61 °C and Tg of -14 to 12 °C; one of them was amorphous. In addition, all co-FPEs s...
Source: Biomacromolecules - April 11, 2024 Category: Biochemistry Authors: Fitrilia Silvianti Dina Maniar Beatriz Agostinho Tijn C de Leeuw Albert Jan Jacob Woortman Jur van Dijken Shanmugam Thiyagarajan Andreia F Sousa Katja Loos Source Type: research
Biomimetic and multifunctional nanocomposites for precision fungi theranostics
Biomaterials. 2024 Apr 4;308:122561. doi: 10.1016/j.biomaterials.2024.122561. Online ahead of print.ABSTRACTFungi infection is a serious threat to public health, but an effective antifungal strategy remains a challenge. Herein, a biomimetic nanocomposite with multifunctionalities, including fungi diagnosis, antifungal adhesion, precise fungi elimination, and cytokine sequestration, is constructed for battling Candida albicans (C. albicans) infection. By screening a range of cells, we find that the polarized macrophage cells have the strongest binding tendency toward C. albicans. Thus, their membranes were exfoliated to cam...
Source: Biomaterials - April 11, 2024 Category: Materials Science Authors: Li Wang Yueyue Gui Kexin Li Wei Tao Chao Li Jin Qiu Jiehua Ma Source Type: research
Biomimetic and multifunctional nanocomposites for precision fungi theranostics
Biomaterials. 2024 Apr 4;308:122561. doi: 10.1016/j.biomaterials.2024.122561. Online ahead of print.ABSTRACTFungi infection is a serious threat to public health, but an effective antifungal strategy remains a challenge. Herein, a biomimetic nanocomposite with multifunctionalities, including fungi diagnosis, antifungal adhesion, precise fungi elimination, and cytokine sequestration, is constructed for battling Candida albicans (C. albicans) infection. By screening a range of cells, we find that the polarized macrophage cells have the strongest binding tendency toward C. albicans. Thus, their membranes were exfoliated to cam...
Source: Biomaterials - April 11, 2024 Category: Materials Science Authors: Li Wang Yueyue Gui Kexin Li Wei Tao Chao Li Jin Qiu Jiehua Ma Source Type: research
The Emergence of Candida auris is Not Associated with Changes in Antifungal Prescription at Hospitals
(Source: Infection and Drug Resistance)
Source: Infection and Drug Resistance - April 11, 2024 Category: Infectious Diseases Tags: Infection and Drug Resistance Source Type: research
