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Potential role of intratumor bacteria in mediating tumor resistance to the chemotherapeutic drug gemcitabine
Growing evidence suggests that microbes can influence the efficacy of cancer therapies. By studying colon cancer models, we found that bacteria can metabolize the chemotherapeutic drug gemcitabine (2',2'-difluorodeoxycytidine) into its inactive form, 2',2'-difluorodeoxyuridine. Metabolism was dependent on the expression of a long isoform of the bacterial enzyme cytidine deaminase (CDDL), seen primarily in Gammaproteobacteria. In a colon cancer mouse model, gemcitabine resistance was induced by intratumor Gammaproteobacteria, dependent on bacterial CDDL expression, and abrogated by cotreatment with the antibiotic ciprofloxa...
Source: ScienceNOW - September 14, 2017 Category: Science Authors: Geller, L. T., Barzily-Rokni, M., Danino, T., Jonas, O. H., Shental, N., Nejman, D., Gavert, N., Zwang, Y., Cooper, Z. A., Shee, K., Thaiss, C. A., Reuben, A., Livny, J., Avraham, R., Frederick, D. T., Ligorio, M., Chatman, K., Johnston, S. E., Mosher, C. Tags: Medicine, Diseases reports Source Type: news

Ciprofloxacin Hydrochloride Tablets (New - Discontinuation)
Drug Shortage (Source: FDA Drug Shortages)
Source: FDA Drug Shortages - September 8, 2017 Category: Drugs & Pharmacology Source Type: news

Aradigm lands NIH grant for inhaled, liposomal products
Aradigm Corp. (NSDQ:ARDM) said today that the National Institute of Allergy and Infectious Diseases and the NIH awarded the company a grant to study the treatment of pulmonary non-tuberculous mycobacteria infections with Aradigm’s inhaled liposomal ciprofloxacin products, Linhaliq and Lipoquin. The two-year grant is worth approximately $972,000, according to the Hayward, Calif.-based company. Get the full story at our sister site, Drug Delivery Business News. The post Aradigm lands NIH grant for inhaled, liposomal products appeared first on MassDevice. (Source: Mass Device)
Source: Mass Device - August 15, 2017 Category: Medical Devices Authors: Sarah Faulkner Tags: Drug-Device Combinations Funding Roundup Pharmaceuticals Respiratory Wall Street Beat Aradigm Corp. Source Type: news

Certain Antibiotics May Increase Risk of Birth Defects
Ciprofloxacin, levofloxacin and other drugs like them should be avoided in pregnancy, a study found. (Source: NYT Health)
Source: NYT Health - July 20, 2017 Category: Consumer Health News Authors: NICHOLAS BAKALAR Tags: Pregnancy and Childbirth Antibiotics Babies and Infants Birth Defects Source Type: news

Toothpaste ingredient linked to antibiotic resistance
Conclusion This study mainly explored why bacterial resistance could be common for both quinolone antibiotics like ciprofloxacin and the antibacterial triclosan. It confirmed previous findings that one cause seems to be bacteria developing mutations in the gyrA gene. In the case of quinolones, the mutation alters the enzyme that they normally bind to. Triclosan resistance is largely because the already-mutant bacteria have boosted stress response pathways, or molecular defences. The main finding of this research was that small triclosan concentrations led to resistant E. coli bacteria becoming the more dominant strains m...
Source: NHS News Feed - July 5, 2017 Category: Consumer Health News Tags: Medication Source Type: news

Rapid Assay Revives Ciprofloxacin Use for Gonorrhea Rapid Assay Revives Ciprofloxacin Use for Gonorrhea
A pharmacogenomics approach identified gonorrhea infections susceptible to ciprofloxacin and allowed physicians to reserve ceftriaxone for resistant cases.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - June 2, 2017 Category: Consumer Health News Tags: Infectious Diseases News Source Type: news

Scientists develop test to identify best treatment for gonorrhea
FINDINGSResearchers from UCLA have developed a laboratory test that helps physicians determine which people with gonorrhea may be more treatable with an antibiotic that has not been recommended since 2007 because of concerns that the resistance to the drug was growing.BACKGROUNDGonorrhea has developed increasing resistance to all current antibiotics. Due to the spread of multi-drug resistant gonorrhea, health authorities have declared it one of the top-three urgent threats to public health.Ciprofloxacin was used to combat the sexually transmitted infection until 2007, when the Centers for Disease Control and Prevention sto...
Source: UCLA Newsroom: Health Sciences - May 23, 2017 Category: Universities & Medical Training Source Type: news

CDC Issues Health Advisory on < i > Shigella < /i >
The CDC has released a Health Alert Network health advisory warning clinicians about emergingShigella strains that show possible reduced susceptibility to ciprofloxacin. (Source: AAFP News)
Source: AAFP News - April 20, 2017 Category: Primary Care Source Type: news

Public Health England (PHE) PGD template for supply of ciprofloxacin (meningoccal disease)
PHE have published this PGD template to support the supply of ciprofloxacin to adults and children for the management of clusters of meningococcal disease, when 2 or more cases are reported in a congregate setting. It is valid from 10 February 2017 until 10 February 2020 (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - February 28, 2017 Category: Consumer Health News Source Type: news

Cat Scratch Disease
Cat scratch disease is an infection transmitted by cat scratches and bites. The lesion is usually small and less than 1 cm in length. It is normally a benign, self-limiting illness lasting for about 6-12 weeks. It is caused by an exposure to bartonella henselae bacteria. Scratches or bites from an infected cat can cause symptoms in people including swollen and draining lymph nodes, fever, fatigue and headache. Swollen, tender, or hard lymph nodes could be confused with a soft tissue tumor. Regional Lymphadenopathy (main clinical feature) These areas of lymph node concentration include cervical nodes, axillary node...
Source: Healthy Living - The Huffington Post - February 2, 2017 Category: Consumer Health News Source Type: news

Teva's Barr Labs Settles Cipro Antitrust Case for $225 Mln Teva's Barr Labs Settles Cipro Antitrust Case for $225 Mln
Teva Pharmaceutical Industries Ltd's Barr Laboratories Inc has reached a $225 million settlement in an antitrust class action that accused the drugmaker of keeping a generic version of Bayer AG's antibiotic ciprofloxacin (Cipro) off the market, court documents showed.Reuters Health Information (Source: Medscape Pathology Headlines)
Source: Medscape Pathology Headlines - January 30, 2017 Category: Pathology Tags: Pathology & Lab Medicine News Source Type: news

Teva's Barr Labs settles Cipro antitrust case for $225 million
(Reuters) - Teva Pharmaceutical Industries Ltd's Barr Laboratories Inc has reached a $225 million settlement in an antitrust class action that accused the drugmaker of keeping a generic version of Bayer AG's antibiotic Cipro off the market, court documents showed. (Source: Reuters: Health)
Source: Reuters: Health - January 27, 2017 Category: Consumer Health News Tags: healthNews Source Type: news

Proquin XR (Ciprofloxacin Hcl) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - December 8, 2016 Category: Drugs & Pharmacology Source Type: news

Cetraxal (Ciprofloxacin Otic Solution) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - December 8, 2016 Category: Drugs & Pharmacology Source Type: news

Cipro I.V. (Ciprofloxacin IV) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - December 8, 2016 Category: Drugs & Pharmacology Source Type: news

NIAID-supported study examines vulnerability of gonorrhea to older antibiotic drug
(NIH/National Institute of Allergy and Infectious Diseases) A new clinical research study seeks to determine whether a rapid molecular diagnostic test can reliably identify gonorrhea infections that may be treated with a single dose of an older antibiotic, ciprofloxacin. The study will enroll up to 381 men and women diagnosed with untreated Neisseria gonorrhoeae. It is sponsored by the National Institute of Allergy and Infectious Diseases and is being conducted by the NIAID-funded Sexually Transmitted Infections Clinical Trials Group at four sites. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - November 17, 2016 Category: Infectious Diseases Source Type: news

Ciloxan Ophthalmic Solution (Ciprofloxacin HCL Ophthalmic Solution) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - October 6, 2016 Category: Drugs & Pharmacology Source Type: news

Cheap Drugs May Have Turned This Indian Lake Into A 'Superbug Hotspot'
Centuries ago, Indian princes would bathe in the cool Kazhipally lake in Medak. Now, even the poorest villagers here in India’s baking south point to the barren banks and frothy water and say they avoid going anywhere near it. A short drive from the bustling tech hub of Hyderabad, Medak is the heart of India’s antibiotics manufacturing business: a district of about 2.5 million that has become one of the world’s largest suppliers of cheap drugs to most markets, including the United States. But community activists, researchers and some drug company employees say the presence of more than 300 drug firms, com...
Source: Healthy Living - The Huffington Post - September 29, 2016 Category: Consumer Health News Source Type: news

Ciprodex (Ciprofloxacin and Dexamethasone ) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - September 21, 2016 Category: Drugs & Pharmacology Source Type: news

Increase in antibiotic-resistant bacteria hinders treatment of kidney infections
The increase in illnesses and deaths linked to medication-resistant bacteria has been well-documented by researchers and received extensive public attention in recent years. Now, UCLA-led research shows how these bacteria are making it more difficult to treat a common but severe kidney infection.Pyelonephritis — infection of the kidney usually caused by E. coli bacteria and which can start as a urinary tract infection — causes fever, back pain and vomiting. About half of people infected require hospitalization. If not treated with effective antibiotics, it can cause sepsis and death.In a UCLA-led study bas...
Source: UCLA Newsroom: Health Sciences - September 16, 2016 Category: Universities & Medical Training Source Type: news

Laboratorios Salvat S.A. and Arbor Pharmaceuticals, LLC Announce the Launch of Otovel (ciprofloxacin 0.3 % and fluocinolone acetonide 0.025 %) Otic Solution
BARCELONA, Spain and ATLANTA, Aug. 29, 2016 /PRNewswire/ -- Laboratorios Salvat S.A. (Salvat) and Arbor Pharmaceuticals, LLC (Arbor) jointly announce the launch of Otovel (ciprofloxacin 0.3 % and fluocinolone acetonide 0.025 %) otic solution, the... (Source: Drugs.com - New Drug Approvals)
Source: Drugs.com - New Drug Approvals - August 29, 2016 Category: Drugs & Pharmacology Source Type: news

Ciloxan Ophthalmic Ointment (Ciprofloxacin HCl Ophthalmic Ointment) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - August 9, 2016 Category: Drugs & Pharmacology Source Type: news

Cipro (Ciprofloxacin) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - August 8, 2016 Category: Drugs & Pharmacology Source Type: news

Cipro XR (Ciprofloxacin Extended-Release) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - August 8, 2016 Category: Drugs & Pharmacology Source Type: news

Yet Another Warning On Fluoroquinolone Antibiotic Side Effects
Rare but significant and debilitating side effects - tendon rupture, peripheral neuropathy - can occur with fluoroquinolone antibiotics like Avelox or Cipro. The FDA is now warning that some of these side effects can occur together and that use of these drugs should be restricted for most uncomplicated infections. (Source: Forbes.com Healthcare News)
Source: Forbes.com Healthcare News - August 1, 2016 Category: Pharmaceuticals Authors: David Kroll Source Type: news

FDA Bolsters Warnings About Class of Antibiotics
Fluoroquinolones such as Cipro, Levaquin should be reserved for life-threatening infections (Source: WebMD Health)
Source: WebMD Health - July 26, 2016 Category: Consumer Health News Source Type: news

FDA Updates Fluoroquinolone Labels to Emphasize Risks for Disabling Adverse Events (FREE)
By Amy Orciari Herman Edited by David G. Fairchild, MD, MPH, and Lorenzo Di Francesco, MD, FACP, FHM The FDA has updated the labels of systemic fluoroquinolones (e.g., ciprofloxacin, levofloxacin) to note that they're associated with numerous serious … (Source: Physician's First Watch current issue)
Source: Physician's First Watch current issue - July 26, 2016 Category: Primary Care Source Type: news

FDA Bolsters Warnings about Class of Antibiotics
Fluoroquinolones such as Cipro, Levaquin should be reserved for life-threatening infections Source: HealthDay Related MedlinePlus Pages: Antibiotics, Drug Safety (Source: MedlinePlus Health News)
Source: MedlinePlus Health News - July 26, 2016 Category: Consumer Health News Source Type: news

FDA Adds Label Warnings on Cipro, Related Drugs
(MedPage Today) -- Strengthens black-box warning on fluoroquinolone antibiotics (Source: MedPage Today Emergency Medicine)
Source: MedPage Today Emergency Medicine - July 26, 2016 Category: Emergency Medicine Source Type: news

Otonomy Announces Assignment of C Code and Pass-Through Payment Status for OTIPRIO(TM)
SAN DIEGO, May 20, 2016 -- (Healthcare Sales & Marketing Network) -- Otonomy, Inc. (OTIC), a biopharmaceutical company focused on the development and commercialization of innovative therapeutics for diseases and disorders of the ear, today announced that t... Biopharmaceuticals, ReimbursementOtonomy, OTIPRIO, ciprofloxacin otic (Source: HSMN NewsFeed)
Source: HSMN NewsFeed - May 20, 2016 Category: Pharmaceuticals Source Type: news

Physicians React to New FDA Warning on Cipro, Similar Drugs
(MedPage Today) -- Experts discuss FDA warning, impact, and other drug choices (Source: MedPage Today Public Health)
Source: MedPage Today Public Health - May 18, 2016 Category: American Health Source Type: news

Otovel (Ciprofloxacin and Fluocinolone Acetonide Otic Solution) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - May 18, 2016 Category: Drugs & Pharmacology Source Type: news

FDA Calls for More Restrictions on Fluoroquinolone Use (FREE)
By Kristin J. Kelley Edited by Susan Sadoughi, MD, and André Sofair, MD, MPH The risks for "disabling and potentially permanent" side effects associated with systemic fluoroquinolone antibacterials (e.g., ciprofloxacin, moxifloxacin) generally outweigh the benefits in patients with … (Source: Physician's First Watch current issue)
Source: Physician's First Watch current issue - May 15, 2016 Category: Primary Care Source Type: news

D.C. Week: Federal Judge Rules Against ACA Subsidies
(MedPage Today) -- FDA warns that Cipro and similar antibiotics should not be used for uncomplicated infections (Source: MedPage Today Psychiatry)
Source: MedPage Today Psychiatry - May 14, 2016 Category: Psychiatry Source Type: news

FDA: Cipro side effects outweigh benefit for some infections
NEW YORK (AP) — The U.S. Food and Drug Administration is ratcheting up its warning about the potential side effects of a type of commonly-prescribed powerful antibiotic often known by the brand name Cipro. (Source: U.S. News - Health)
Source: U.S. News - Health - May 13, 2016 Category: Consumer Health News Source Type: news

FDA: Avoid Cipro, Similar Drugs for Common Infections
(MedPage Today) -- Agency says risks outweigh benefits (Source: MedPage Today Public Health)
Source: MedPage Today Public Health - May 12, 2016 Category: American Health Source Type: news

Preventing Medication Errors: Lessons From a Patient
A Nurse Aide, an Emergency Room Clerk, and a Patient I have great appreciation for doctors and nurses, hospitals, and patients. In high school I worked as a nurse aide in a convalescent home. I fed, dressed, and showered elderly patients, many of them immobile. I shaved gentlemen's facial stubble and polished ladies' fingernails. In college and in graduate school, I worked as an emergency room clerk. I witnessed a lot, including amazing doctors and nurses caring for patients and saving lives. I have also been a patient. First, when I had an appendectomy at age eight and then when I gave natural childbirth twice. All were...
Source: Healthy Living - The Huffington Post - May 2, 2016 Category: Consumer Health News Source Type: news

Digital Attraction
From its formation in 1863, Bayer AG has been a hugely influential and innovative chemical, scientific and pharma company, developing aspirin in 1899 and popularizing the pill, as a form of contraception, in the 1960s. More recently, it introduced the top-selling, second-generation quinolone antibiotic, Cipro, plus anti-cancer drug Nexavar. But to ensure its future is as bright as its past – and keep it at the forefront of pharma – Bayer is wholeheartedly embracing cutting-edge technology and is going digital. However, when your organization was founded over 150 years ago and is a huge multinational with over 1...
Source: EyeForPharma - April 26, 2016 Category: Pharmaceuticals Authors: Women in Pharma Source Type: news

Order Permitting Emergency Dispensing of Oral Formulations of Ciprofloxacin and Waiver of CGMP (Current Good Manufacturing Practice) Requirements During an Anthrax Emergency
U.S. Food and Drug Administration. 04/13/2016This six-page document is the order to permit emergency dispensing of Food and Drug Administration-approved oral dosage forms of ciprofloxacin products ("eligible ciprofloxacin products") for the post-exposure prophylaxis of inhalational anthrax during an emergency involving Bacillus (B.) anthracis, the biological agent that causes anthrax disease. It will allow stakeholders to implement plans for emergency dispensing of eligible ciprofloxacin products without individual prescriptions in the future if they reasonably believe there is a need to do so because of their co...
Source: Disaster Lit: Resource Guide for Disaster Medicine and Public Health - April 15, 2016 Category: Global & Universal Authors: The U.S. National Library of Medicine Source Type: news

Antibiotics Side Effects on the Mitochondria
Science is just beginning to understand how important your mitochondria are to warding off the diseases of aging. And, as usual, mainstream medicine is lagging way behind. Along with your telomeres, the cellular time keepers at the ends of your chromosomes, your mitochondria are another key component of the anti-aging equation. You see, these tiny organelles in your cells are the power plants that turn fuel into energy for your body. Healthy mitochondria keep you young and energetic.  Research shows that damaged mitochondria can lead to: Schizophrenia and bipolar disorder; Alzheimer’s and Parkinson’s d...
Source: Al Sears, MD Natural Remedies - March 25, 2016 Category: Complementary Medicine Authors: Al Sears Tags: Natural Cures Source Type: news

You Need to Know: Where the 2016 Presidential Candidates Stand on Food Policy
At this point in the campaign race, we know the candidates' beliefs on issues like war, immigration and Wall Street. But what about food? I wrangled all the information I could find--from tweets to votes--to see where the candidates stand on issues of food policy. Keep in mind, I'm not saying who's right or wrong, just pulling together quotes and votes to help us understand how each candidate views the issues. If I have noted "No public comment available" but you know of a public comment, please add it to the comments below with a link to the original source. Hillary Clinton On food security: Clinton has tweet...
Source: Science - The Huffington Post - February 18, 2016 Category: Science Source Type: news

Common Antibiotics May Cause Delirium, Confusion And Hallucinations
I have long had severe reservations about quinolone antibiotics, like Levaquin and Cipro. I have had these concerns since I conducted clinical trials to test new antibiotics (including a variety of quinolones) before they went to market. Now I have further concerns about them because of their overuse as an alternative to busy physicians trying to puzzle out what’s wrong with the patient, and because practice “guidelines” promote their overuse. (Source: Forbes.com Healthcare News)
Source: Forbes.com Healthcare News - February 18, 2016 Category: Pharmaceuticals Authors: Judy Stone Source Type: news

Ciprofloxacin Resistance in E. coli Urinary Tract InfectionsCiprofloxacin Resistance in E. coli Urinary Tract Infections
How prevalent is ciprofloxacin resistance in E. coli UTIs? BMC Infectious Diseases (Source: Medscape Pathology Headlines)
Source: Medscape Pathology Headlines - February 17, 2016 Category: Pathology Tags: Infectious Diseases Journal Article Source Type: news

Otonomy Announces Publication Supporting Development of OTO-104 as Protectant Against Cisplatin-Induced Hearing Loss
SAN DIEGO, Jan. 26, 2016 -- (Healthcare Sales & Marketing Network) -- Otonomy, Inc. (OTIC), a biopharmaceutical company focused on the development and commercialization of innovative therapeutics for diseases and disorders of the ear, today announced the p... Biopharmaceuticals, OncologyOtonomy, Dexamethasone, Cisplatin-Induced Hearing Loss, ciprofloxacin (Source: HSMN NewsFeed)
Source: HSMN NewsFeed - January 26, 2016 Category: Pharmaceuticals Source Type: news

Otiprio (Ciprofloxacin Otic Suspension) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - December 23, 2015 Category: Drugs & Pharmacology Source Type: news

FDA OKs Otiprio for Kids Getting Tympanostomy Tube PlacementFDA OKs Otiprio for Kids Getting Tympanostomy Tube Placement
Ciprofloxacin otic suspension is indicated for children with bilateral otitis media with effusion undergoing tympanostomy tube placement. Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - December 14, 2015 Category: Consumer Health News Tags: Pediatrics News Alert Source Type: news

Another 'gift' from Big Pharma: Drug-resistant stomach bug spreads across America
(NaturalNews) Many frequent international travelers have their doctor prescribe Cipro or other antibiotics when they travel out of the country for any length of time. Having this along won't be helping against a new strain of bacteria according to the Centers for Disease Control ... (Source: NaturalNews.com)
Source: NaturalNews.com - December 11, 2015 Category: Consumer Health News Source Type: news

Let's Give Thanks and Hope We Haven't Lost the War Against Superbugs
Our holiday season has begun with an ominous report: In China, bacteria with a dangerous new antibiotic-resistance gene have spread from livestock to people. This gene bestows resistance against colistin -- an antibiotic that has become our last hope for treating people infected with some of the worst superbugs. The scariest part is that the gene can make copies of itself and then jump between bacteria. History shows us that these mobile resistance genes can spread around the world quickly, silently hitchhiking in the guts of people and animals or on the surface of food. Consequently, this could be our last Thanksgiving wh...
Source: Science - The Huffington Post - November 24, 2015 Category: Science Source Type: news

FDA Advisers Recommend Stronger Warnings on Fluoroquinolones (FREE)
By Amy Orciari Herman Edited by Susan Sadoughi, MD, and André Sofair, MD, MPH An FDA advisory panel voted late last week to recommend stronger label warnings on fluoroquinolones (e.g., ciprofloxacin) when used to treat sinus … (Source: Physician's First Watch current issue)
Source: Physician's First Watch current issue - November 8, 2015 Category: Primary Care Source Type: news

I-Team: Mass. Families To Share Antibiotic Horror Stories With FDA
BOSTON (CBS) – Fluoroquinolones are a powerful family of antibiotics that can save lives. In serious cases, doctors often don’t have other options. But as the I-Team first reported last year, these drugs can often cause debilitating side effects. Critics maintain they are over-prescribed. On Thursday, the Food and Drug Administration will hold a meeting to consider changing how these drugs are used. Massachusetts families plan on attending to share how these drugs devastated them. Nick Newell will tell federal regulators how his brother Ollie started a downward spiral after taking several doses of Ciprofloxacin...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - November 5, 2015 Category: Consumer Health News Authors: deanreddington Tags: Health i-Team Local News Seen On WBZ-TV Syndicated Local Watch Listen Fluoroquinolones Lauren Leamanczyk Source Type: news