Synergistic Inhibitions of Gram-negative Bacteria by Combination Treatment with Ciprofloxacin and a Novel Glucolipid
Chem Biodivers. 2024 Apr 17:e202400578. doi: 10.1002/cbdv.202400578. Online ahead of print.ABSTRACTPsychrophilic fungus Pseudogymnoascus sp. OUCMDZ-4032 derived from Antarctica was cultivated under 16 ℃ to produce a new glucolipid compound (1). Its structure was elucidated by analysis of detailed spectroscopic data, acid hydrolysis and 1-phenyl-3-methyl-5-pyrazolone precolumn derivatization, and 13C NMR quantum chemical calculations. Though compound 1 did not show inhibitory activity against bacteria, it can reduce the minimum inhibitory concentration (MIC) of ciprofloxacin against Gram-negative bacteria Pseudomonas aeru...
Source: Chemistry and Biodiversity - April 18, 2024 Category: Biochemistry Authors: Liyuan Yang Qingqing Zhang Deng Yu Weiming Zhu Yi Wang Source Type: research
Challenges in the treatment of pediatric Mycoplasma pneumoniae pneumonia
Conclusion: This report summarizes the clinical significance of macrolide-resistant and refractory MP pneumonia and discusses the efficacy and safety of alternative drugs, with a stepwise approach to the management of MP pneumonia recommended from the viewpoint of clinical practice.What is Known:•Although MP pneumonia is usually a benign self-limited infection with response macrolides as first line therapy,severe life-threatening cases may develop if additional treatment strategies are not effectively implemented.•Macrolide-resistant and refractory MP pneumonia are two conditions that may complicate the clinical cour...
Source: European Journal of Pediatrics - April 18, 2024 Category: Pediatrics Source Type: research
Minimum inhibitory concentrations of Neisseria gonorrhoeae strains in clients of the Amsterdam sexual health clinic with a Dutch versus an international sexual network
Conclusions
For three cephalosporin antibiotics, we found Ng strains with slightly higher MICs in clients with partner(s) from Europe or Latin America and the Caribbean. International travel might contribute to the spread of Ng with lower susceptibility. More understanding of the emergence of AMR Ng is needed. (Source: Sexually Transmitted Infections)
Source: Sexually Transmitted Infections - April 18, 2024 Category: Sexual Medicine Authors: Teker, B., Schim van der Loeff, M., Hoornenborg, E., Boyd, A., Reedijk, S., van Dam, A., Jongen, V. W., de Vries, H. Tags: Original research Source Type: research
In vitro antibacterial activity of antibiotics and plant essential oils against Escherichia coli MTCC443 supported through the molecular docking and pharmacokinetics study
This study has been made to compare the in vitro antibacterial activity and further validated the same through the molecular docking study of 13 antibiotics such as ciprofloxacin, chloramphenicol, erythromycin, ampicillin, cefotaxime, rifampicin, kanamycin, vancomycin, streptomycin, penicillin, nalidixic acid, trimethoprim, and polymyxin, and 10 EOs such as garlic, tulsi, neem, clove, thyme, peppermint, coriander, tea, lavender, and eucalyptus against the target protein (DNA gyrase) ofE. coli MTCC443.E. coli Microbial Type Culture Collection 443 was found to be highly sensitive to ciprofloxacin (zone of inhibition [ZOI], 2...
Source: Biotechnology and Applied Biochemistry - April 17, 2024 Category: Biochemistry Authors: Saurabh Jain,
Adarsh Kumar Shukla,
Surbhi Panwar,
Rajesh Kumar,
Ashwani Kumar Tags: ORIGINAL ARTICLE Source Type: research
Predominance of multidrug-resistant < i > Salmonella < /i > Typhi genotype 4.3.1 with low-level ciprofloxacin resistance in Zanzibar
ConclusionsWe report a high rate of MDR and low-level ciprofloxacin resistantS. Typhi circulating in Zanzibar, belonging to genotype 4.3.1.1, which is widespread in Southeast Asia and African countries and associated with low-level ciprofloxacin resistance. Few therapeutic options are available for treatment of typhoid fever in the study setting. Surveillance of the prevalence, spread and antimicrobial susceptibility ofS. Typhi can guide treatment and control efforts. (Source: PLoS Neglected Tropical Diseases)
Source: PLoS Neglected Tropical Diseases - April 17, 2024 Category: Tropical Medicine Authors: Annette Onken Source Type: research
Six-year progression of medically treated infective aortitis
CONCLUSIONS: Infective aortitis with mycotic aneurysms is usually treated surgically due to the significant risk of rupture in the acute period. This case suggests that if the acute infective period is passed, the aneurysmal disease stabilises and does not progress.PMID:38626935 | DOI:10.1177/17085381241248724 (Source: Vascular)
Source: Vascular - April 16, 2024 Category: Surgery Authors: Daniel Zhang Arvind Dhas Lee Source Type: research
Six-year progression of medically treated infective aortitis
CONCLUSIONS: Infective aortitis with mycotic aneurysms is usually treated surgically due to the significant risk of rupture in the acute period. This case suggests that if the acute infective period is passed, the aneurysmal disease stabilises and does not progress.PMID:38626935 | DOI:10.1177/17085381241248724 (Source: Vascular)
Source: Vascular - April 16, 2024 Category: Surgery Authors: Daniel Zhang Arvind Dhas Lee Source Type: research
Anaerobic co-metabolic biodegradation of pharmaceuticals and personal care products driven by glycerol fermentation
This study showed evidence that glycerol co-fermentation can exert a synergistic effect on the PPCPs removal during anaerobic digestion mediated by heterotrophic co-metabolism.PMID:38621493 | DOI:10.1016/j.chemosphere.2024.142006 (Source: Chemosphere)
Source: Chemosphere - April 15, 2024 Category: Chemistry Authors: Rodrigo B Carneiro Gisele M Gomes Franciele P Camargo Marcelo Zaiat Álvaro J Santos-Neto Source Type: research
Anaerobic co-metabolic biodegradation of pharmaceuticals and personal care products driven by glycerol fermentation
This study showed evidence that glycerol co-fermentation can exert a synergistic effect on the PPCPs removal during anaerobic digestion mediated by heterotrophic co-metabolism.PMID:38621493 | DOI:10.1016/j.chemosphere.2024.142006 (Source: Chemosphere)
Source: Chemosphere - April 15, 2024 Category: Chemistry Authors: Rodrigo B Carneiro Gisele M Gomes Franciele P Camargo Marcelo Zaiat Álvaro J Santos-Neto Source Type: research
TiO < sub > 2 < /sub > Nanorod Decorated with MoS < sub > 2 < /sub > Nanospheres: An Efficient Dual-functional Photocatalyst for Antibiotic Degradation and Hydrogen Production
This article presents the engineering of a binary heterostructured photocatalyst by combining TiO2 (nanorods) and MoS2 nanosphere using a straightforward solvothermal method and the assessment of the phase structures, morphologies, and optical properties of the resulting nanocomposites using diverse analytical techniques. The TiO2(Rod)/MoS2 composite exhibits remarkable efficacy in degrading ciprofloxacin, achieving 93% removal rate within one hour, which is four times higher than that of bare TiO2. Moreover, the optimized TiO2(Rod)/MoS2 presents an outstanding hydrogen production rate of 7415 μmol g-1, which is ∼24 tim...
Source: Chemosphere - April 14, 2024 Category: Chemistry Authors: Muniyandi Govinda Raj Shanmugam Mahalingam Solomon Vasthi Gnanarani Charmakani Jayashree Ayyakannu Sundaram Ganeshraja Nalandhiran Pugazhenthiran Mostafizur Rahaman Srinivasan Abinaya Bakthavatchalam Senthil Junghwan Kim Source Type: research
Highly efficient targeted adsorption and catalytic degradation of ciprofloxacin by a novel molecularly imprinted bimetallic MOFs catalyst for persulfate activation
This study opens up a new platform for the targeted removal of target pollutants in AOPs.PMID:38615958 | DOI:10.1016/j.chemosphere.2024.141894 (Source: Chemosphere)
Source: Chemosphere - April 14, 2024 Category: Chemistry Authors: Yang Zhang Wenqian Zhao Xiaodong Zhang Shuguang Wang Source Type: research
Interaction of beauvericin in combination with antibiotics against methicillin-resistant Staphylococcus aureus and Salmonella typhimurium
Toxicon. 2024 Apr 12:107713. doi: 10.1016/j.toxicon.2024.107713. Online ahead of print.ABSTRACTMultidrug resistance in bacteria is a major challenge worldwide, increasing both mortality by infections and costs for the health systems. Therefore, it is of utmost importance to find new drugs against resistant bacteria. Beauvericin (BEA) is a mycotoxin produced by entomopathogenic and other fungi of the genus Fusarium. Our work determines the effect of BEA combined with antibiotics, which has not been previously explored. The combination analysis included different antibiotics against non-methicillin-resistant Staphylococcus a...
Source: Toxicon - April 14, 2024 Category: Toxicology Authors: V ásquez Bonilla J Norberto Barranco Florido J Esteban A Hamdan Partida Ponce Alquicira Edith Octavio Loera Source Type: research
TiO < sub > 2 < /sub > Nanorod Decorated with MoS < sub > 2 < /sub > Nanospheres: An Efficient Dual-functional Photocatalyst for Antibiotic Degradation and Hydrogen Production
This article presents the engineering of a binary heterostructured photocatalyst by combining TiO2 (nanorods) and MoS2 nanosphere using a straightforward solvothermal method and the assessment of the phase structures, morphologies, and optical properties of the resulting nanocomposites using diverse analytical techniques. The TiO2(Rod)/MoS2 composite exhibits remarkable efficacy in degrading ciprofloxacin, achieving 93% removal rate within one hour, which is four times higher than that of bare TiO2. Moreover, the optimized TiO2(Rod)/MoS2 presents an outstanding hydrogen production rate of 7415 μmol g-1, which is ∼24 tim...
Source: Chemosphere - April 14, 2024 Category: Chemistry Authors: Muniyandi Govinda Raj Shanmugam Mahalingam Solomon Vasthi Gnanarani Charmakani Jayashree Ayyakannu Sundaram Ganeshraja Nalandhiran Pugazhenthiran Mostafizur Rahaman Srinivasan Abinaya Bakthavatchalam Senthil Junghwan Kim Source Type: research
Highly efficient targeted adsorption and catalytic degradation of ciprofloxacin by a novel molecularly imprinted bimetallic MOFs catalyst for persulfate activation
This study opens up a new platform for the targeted removal of target pollutants in AOPs.PMID:38615958 | DOI:10.1016/j.chemosphere.2024.141894 (Source: Chemosphere)
Source: Chemosphere - April 14, 2024 Category: Chemistry Authors: Yang Zhang Wenqian Zhao Xiaodong Zhang Shuguang Wang Source Type: research
Unveiling novel threats: Urban river isolation of Aeromonas veronii with unusual VEB-28 extended-spectrum β-lactamase and distinct mcr variants
In conclusion, our findings suggest that A. veronii may serve as an environmental reservoir for ARGs and virulence factors, highlighting its importance as a potential pathogen in public health.PMID:38614394 | DOI:10.1016/j.chemosphere.2024.141918 (Source: Chemosphere)
Source: Chemosphere - April 13, 2024 Category: Chemistry Authors: Fernanda Fernandes Santos Tiago Barcelos Valiatti Andr é Valêncio Ághata Cardoso da Silva Ribeiro Ana Paula Streling T ânia A Tardelli Gomes Rodrigo Cay ô Ana Cristina Gales Source Type: research
