Antibiotic Prescribing Choices and Their Comparative C. Difficile Infection Risks: A Longitudinal Case-Cohort Study, Clinical Infectious Diseases 72(5): 836-844

Conclusions C. difficile infection risk increases with antibiotic duration, and there are wide disparities in risks associated with antibiotic courses used for similar indications.
Source: Current Awareness Service for Health (CASH) - Category: Consumer Health News Source Type: news

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Describe the basic steps of a probiotic protocol designed to reduce the incidence of healthcare-associated C. difficile infections.
Source: Journal of the American Dietetic Association - Category: Nutrition Authors: Tags: Monday, October 18, 2021 Source Type: research
Purpose of review Although the epidemiology of Clostridioides difficile has changed, this organism continues to cause significant morbidity and mortality. This review addresses current and future approaches to the diagnosis of C. difficile disease. Recent findings Over the last several years, large prospective studies have confirmed that there is no single optimal test for the diagnosis of C. difficile disease. The pendulum has swung from a focus on rapid molecular diagnosis during the years of the ribotype 027 epidemic, to a call for use of algorithmic approaches that include a test for toxin detection. In addi...
Source: Current Opinion in Infectious Diseases - Category: Infectious Diseases Tags: GASTROINTESTINAL INFECTIONS: Edited by James A. Platts-Mills Source Type: research
Purpose of review The US Centers for Disease Control and Prevention (CDC) classified Clostridioides difficile as an ‘urgent’ public health threat that requires ‘urgent and aggressive action’. This call to action has led to new discoveries that have advanced C. difficile infection (CDI) epidemiology, diagnosis and treatment, albeit predominantly in adults. In 2017, the Infectious Diseases Society of America and Society for Healthcare Epidemiology of America published clinical practice guidelines for both adults and children. At that time, recommendations in children were generally limited to rela...
Source: Current Opinion in Infectious Diseases - Category: Infectious Diseases Tags: PAEDIATRIC AND NEONATAL INFECTIONS: Edited by Scott H. James and David W. Kimberlin Source Type: research
arol Połom Nowadays, allogenic hematopoietic stem cell transplantation (allo-HSCT) is a curative therapy that is mainly recommended for hematologic malignancies. However, complications (such as graft-versus-host disease, mucositis, disease relapse, and infections) associated with the HSCT procedure contribute to the development of gut microbiota imbalance, gut-barrier disruption, and increased intestinal permeability. In the present narrative review, the crosstalk between gut microbiota products and intestinal homeostasis is discussed. Notably, gut-microbiota-related aspects have an impact on patients’ clinical ...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research
Skinmed. 2021 Aug 1;19(4):270-273. eCollection 2021.ABSTRACTClostridium difficile infection is mainly the result of antibiotic usage which disturbs the normal microbial flora. Antibiotic-resistant strains of C. difficile have emerged which have limited the number of therapeutic options. We sought to determine if compound RNW03, a broad spectrum anti-microbial formula, would be effective in inhibiting C. difficile and its antibiotic-resistant subtypes. Compound RNW03 was titrated and added to standard concentrations of C. difficile. The wells were incubated in an anaerobic chamber for 48 hours followed by a cell count. Comp...
Source: Skinmed - Category: Dermatology Authors: Source Type: research
Clostridioides difficile is a major cause of nosocomial infection worldwide causing antibiotic-associated diarrhea and some cases are leading to pseudomembranous colitis. The main virulence factors are toxin A and toxin B. Hypervirulent strains of C. difficile are linked to higher mortality rates and most of these strains produce additionally the C. difficile binary toxin (CDT) that possesses two subunits, CDTa and CDTb. The latter is responsible for binding and transfer of CDTa into the cytoplasm of target cells; CDTa is an ADP ribosyltransferase catalyzing the modification of actin fibers that disturbs the actin vs micro...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
by Sirirak Arthithanyaroj, Surang Chankhamhaengdecha, Urai Chaisri, Ratchaneewan Aunpad, Amornrat AroonnualClostridioides difficile infection is the most common cause of nosocomial and antibiotic-associated diarrhea.C.difficile treatment is increasingly likely to fail, and the recurrence rate is high. Antimicrobial peptides are considered an alternative treatment for many infectious diseases, including those caused by antibiotic resistant bacteria. In the present study, we identified a CM peptide, a hybrid of cecropin A and melittin, and its derivative which possesses potent antimicrobial activity againstC.difficile strain...
Source: PLoS One - Category: Biomedical Science Authors: Source Type: research
Conclusion: This scoping review identified the AMS and IP interventions targeting C. difficile and CRKP in healthcare settings and described their key outcomes. The application of behaviour change principles in AMS and IP interventions appears to be limited.
Source: Current Awareness Service for Health (CASH) - Category: Consumer Health News Source Type: news
The involvement of the enteric nervous system, which is a source of S100B, in Clostridioides difficile (C. difficile) infection (CDI) is poorly understood although intestinal motility dysfunctions are known to occur following infection. Here, we investigated the role of S100B in CDI and examined the S100B signaling pathways activated in C. difficile toxin A (TcdA)- and B (TcdB)-induced enteric glial cell (EGC) inflammatory response. The expression of S100B was measured in colon tissues and fecal samples of patients with and without CDI, as well as in colon tissues from C. difficile-infected mice. To investigate the role of...
Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research
Linda Ann Sasser has had ulcerative colitis since she was 20, but it wasn’t until May 2019, about 30 years later, that her condition hit a low point: not only did she have a major flare-up of chronic inflammatory bowel disease (IBD), but on top of it, she had Clostridioides difficile (or C. diff), a highly contagious bacterial infection that causes severe diarrhea and inflammation of the colon. “I became really, really sick with bloody diarrhea 30 times a day and chronic stomach pain,” Sasser says. While hospitalized for 12 days, she was given oral steroid medications, which didn’t help, then IV ste...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized Disease feature Source Type: news
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