NUDT15 Polymorphism Confer Increased Susceptibility to Thiopurine-Induced Leukopenia in Patients With Autoimmune Hepatitis and Related Cirrhosis

Conclusion We found that a NUDT15 polymorphism (rs116855232) was significantly associated with AZA-induced leukopenia in Chinese patients with AIH and related cirrhosis. For patients with the heterozygous variants, low-dose AZA (0.96 mg ⋅ kg−1 ⋅ d−1) is safe for maintaining remission and achieving efficacy comparable to that observed in wild-type patients. Even for patients with previous leukopenia or cirrhosis, AZA treatment may not be contraindicated if NUDT15 genotypes permitted. Ethics Statement This study was carried out in accordance with the recommendations of the ethical guidelines and approved by the Ethics Committee of the West China Hospital, Sichuan University (no. 2013221) with written informed consent from all subjects. All subjects gave written informed consent in accordance with the Declaration of Helsinki. Author Contributions XF and DY wrote the manuscript. LY and HX designed the research. XF, DY, and RM performed the research. XF, DY, and RM analyzed the data. Funding This study was funded by grant from the National Natural Science Foundation of China (No. 81770568 to LY) and the fundamental research funds for Central Universities (No. 2012017yjsy198 to XF). Conflict of Interest Statement The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Supplementary Material The Supplementary Material for this ar...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research