Expression of HLA-DR and KLRG1 enhances the cytotoxic potential and cytokine secretion capacity of CD3 < sup > + < /sup > T cells in tuberculosis patients
CONCLUSIONS: Expression of HLA-DR and KLRG1 enhances the cytotoxic potential and cytokine secretion capacity of CD3+ T cells in TB patients, suggesting CD3+ T cells expressing HLA-DR and KLRG1 are important effector cell phenotypes involved in the host anti-TB infection. HLA-DR and KLRG1 expressed by CD3+ T cells may be potential predictive markers of TB disease progression and clinical immune assessment.PMID:38652959 | DOI:10.1016/j.intimp.2024.112115 (Source: International Immunopharmacology)
Source: International Immunopharmacology - April 23, 2024 Category: Allergy & Immunology Authors: Yiqi Yang Hanlu Shi Yu Zhou Yonglie Zhou Source Type: research
Cell wall synthesizing complexes in Mycobacteriales
Curr Opin Microbiol. 2024 Apr 22;79:102478. doi: 10.1016/j.mib.2024.102478. Online ahead of print.ABSTRACTMembers of the order Mycobacteriales are distinguished by a characteristic diderm cell envelope, setting them apart from other Actinobacteria species. In addition to the conventional peptidoglycan cell wall, these organisms feature an extra polysaccharide polymer composed of arabinose and galactose, termed arabinogalactan. The nonreducing ends of arabinose are covalently linked to mycolic acids (MAs), forming the immobile inner leaflet of the highly hydrophobic MA membrane. The contiguous outer leaflet of the MA membra...
Source: Current Opinion in Microbiology - April 23, 2024 Category: Microbiology Authors: Fabian M Meyer Marc Bramkamp Source Type: research
Mycobacterium tuberculosis Infection in School Contacts of Tuberculosis Cases: A Systematic Review and Meta-Analysis
Am J Trop Med Hyg. 2024 Apr 23:tpmd230038. doi: 10.4269/ajtmh.23-0038. Online ahead of print.ABSTRACTSubstantial tuberculosis transmission occurs outside of households, and tuberculosis surveillance in schools has recently been proposed. However, the yield of tuberculosis outcomes from school contacts is not well characterized. We assessed the prevalence of Mycobacterium tuberculosis infection among close school contacts by performing a systematic review. We searched PubMed, Elsevier, China National Knowledge Infrastructure, and Wanfang databases. Studies reporting the number of children who were tested overall and who tes...
Source: The American Journal of Tropical Medicine and Hygiene - April 23, 2024 Category: Tropical Medicine Authors: Wenjin Wang Aohan Liu Xinjie Liu Nannan You Zhan Wang Cheng Chen Limei Zhu Leonardo Martinez Wei Lu Qiao Liu Source Type: research
The Importance of QuantiFERON Gold Plus Test for the Diagnosis of Presumed Ocular Tuberculosis
Klin Monbl Augenheilkd. 2024 Apr;241(4):432-434. doi: 10.1055/a-2244-6657. Epub 2024 Apr 23.NO ABSTRACTPMID:38653273 | DOI:10.1055/a-2244-6657 (Source: Klinische Monatsblatter fur Augenheilkunde)
Source: Klinische Monatsblatter fur Augenheilkunde - April 23, 2024 Category: Opthalmology Authors: Francesca Bruzzone Margherita Plebani Aikaterini Koryllou Matthieu Perreau Yan Guex-Crosier Source Type: research
CBNAAT: An Emerging Xpert in Diagnosis of Head and Neck Tuberculosis
ConclusionCBNAAT has a promising role in early diagnosis of head and neck tuberculosis as well as other cases of smear negative tuberculosis such as MDR TB and TB-HIV and is optimal for the diagnosis of lymph node tuberculosis and helps in early identification and initiation of treatment. Sensitivity of CBNAAT scored twice as high in comparison with microscopy thus doubling the proportion of rapid diagnoses with important effect on the patient ’s outcome. (Source: Indian Journal of Otolaryngology and Head and Neck Surgery)
Source: Indian Journal of Otolaryngology and Head and Neck Surgery - April 23, 2024 Category: ENT & OMF Source Type: research
Long term outcomes of augmentation cystoplasty in genitourinary tuberculosis in adults: a 12-year follow-up experience at a tertiary single center
To evaluate the long-term effectiveness and consequences of augmentation cystoplasty in adult patients with small capacity bladder due to genitourinary tuberculosis (GUTB). (Source: Urology)
Source: Urology - April 23, 2024 Category: Urology & Nephrology Authors: Rudra Prasad Ghorai, Siddharth Jain, Brusabhanu Nayak, Prashant Singh, Rishi Nayyar, Rajeev Kumar, Amlesh Seth Source Type: research
A case of disseminated nocardiosis with orbital apex involvement and endophthalmitis
We report a case of disseminated nocardiosis with orbital apex involvement and endophthalmitis in an immunocompromised patient. The patient presented with respiratory sepsis, and later developed complete ptosis and ophthalmoplegia in the left eye. This was on the background of treatment with high-dose prednisolone. Magnetic resonance imaging showed enhancement of the entire clivus, extending into the left orbital apex and cavernous sinus. The patient was initially treated empirically for CNS tuberculosis. Bronchoscopic cultures returned positive for Nocardia farcinica, and the patient was treated with trimethoprim/sulfamet...
Source: Orbit - April 22, 2024 Category: Opthalmology Authors: Reema Madike Khizar Rana Sandy Patel Dinesh Selva Source Type: research
Vigilance Needed in Treating a Child with Disseminated TB: A Case Report
CONCLUSION: The diagnosis of tuberculosis in children is difficult because of the mild, nonspe-cific clinical presentation, which usually reflects the implicated underlying organ. In addition to prompt diagnosis and treatment of disseminated TB, careful monitoring is equally important.PMID:38644704 | DOI:10.2174/0118715265287146240405075930 (Source: Infectious Disorders Drug Targets)
Source: Infectious Disorders Drug Targets - April 22, 2024 Category: Infectious Diseases Authors: Hemasri Velmurugan Krishnapriya Neelambaran Meenalotchini Prakash Gurunthalingam Dushyant Chouhan Pugazhenthan Thangaraju Bikram Keshari Kar Nitin Rewaram Gaikwad Source Type: research
Immune profiles of MCP-1 with M tb antigens and recombinant cytokines stimulation in tuberculosis
In conclusion, the study determined the differential expression and production of MCP-1 with M tb antigens and recombinant cytokines. Further, cohort studies are required to study these interaction to identify the high risk individuals, which might help for TB control.PMID:38648681 | DOI:10.1016/j.cyto.2024.156622 (Source: Cytokine)
Source: Cytokine - April 22, 2024 Category: Molecular Biology Authors: Ashwini Pullagurla Bhagyalaxmi Rapolu Shazia Ahmad Sumanlatha Gaddam Source Type: research
Oligomerization states of the Mycobacterium tuberculosis RNA polymerase core and holoenzymes
Arch Microbiol. 2024 Apr 22;206(5):230. doi: 10.1007/s00203-024-03955-z.ABSTRACTDuring the past few decades, a wealth of knowledge has been made available for the transcription machinery in bacteria from the structural, functional and mechanistic point of view. However, comparatively little is known about the homooligomerization of the multisubunit M. tuberculosis RNA polymerase (RNAP) enzyme and its functional relevance. While E. coli RNAP has been extensively studied, many aspects of RNAP of the deadly pathogenic M. tuberculosis are still unclear. We used biophysical and biochemical methods to study the oligomerization s...
Source: Archives of Microbiology - April 22, 2024 Category: Microbiology Authors: Sandrea Maureen Francis Shehna Pattar Kadavan Ramanathan Natesh Source Type: research
Improved antioxidant and anti-tubercular potential of liquiritigenin grafted on low molecular weight chitosan from gladius of Sepioteuthis lessoniana
In conclusion the in vitro antioxidant and the anti-tuberculosis (anti-TB) properties of the grafted samples were significantly (P < 0.001) increased compared to the unconjugated LMW-CH and LTG. Overall, functionalization of LTG with LMW-CH improved the anti-tuberculosis activity. Further studies are needed to explore the possibilities of its use in vivo models.PMID:38649074 | DOI:10.1016/j.ijbiomac.2024.131728 (Source: International Journal of Biological Macromolecules)
Source: International Journal of Biological Macromolecules - April 22, 2024 Category: Biochemistry Authors: Katriel Erica Aavula Thabitha Kesavarao Kumar Ebenezar Swastik Satyapal Ankit Kumar Vijayakumar Abishek Narayansami Mohana Priya Gururaja Perumal Pazhani Saravanan Ramachandran Source Type: research
Another Step Closer to Genomic-informed Therapeutic Dosing for Tuberculosis Drugs
Am J Respir Crit Care Med. 2024 Apr 22. doi: 10.1164/rccm.202403-0566ED. Online ahead of print.NO ABSTRACTPMID:38648185 | DOI:10.1164/rccm.202403-0566ED (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - April 22, 2024 Category: Respiratory Medicine Authors: Paul K Drain Source Type: research
A Nanopore Sequencing-based Pharmacogenomic Panel to Personalize Tuberculosis Drug Dosing
CONCLUSION: Targeted sequencing can enable detection of polymorphisms influencing TB drug metabolism on a low-cost, portable instrument to personalize dosing for TB treatment or prevention. This article is open access and distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/).PMID:38647526 | DOI:10.1164/rccm.202309-1583OC (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - April 22, 2024 Category: Respiratory Medicine Authors: Renu Verma Kesia Esther da Silva Neesha Rockwood Roeland E Wasmann Nombuso Yende Taeksun Song Eugene Kim Paolo Denti Robert J Wilkinson Jason R Andrews Source Type: research
Another Step Closer to Genomic-informed Therapeutic Dosing for Tuberculosis Drugs
Am J Respir Crit Care Med. 2024 Apr 22. doi: 10.1164/rccm.202403-0566ED. Online ahead of print.NO ABSTRACTPMID:38648185 | DOI:10.1164/rccm.202403-0566ED (Source: Respiratory Care)
Source: Respiratory Care - April 22, 2024 Category: Respiratory Medicine Authors: Paul K Drain Source Type: research
A Nanopore Sequencing-based Pharmacogenomic Panel to Personalize Tuberculosis Drug Dosing
CONCLUSION: Targeted sequencing can enable detection of polymorphisms influencing TB drug metabolism on a low-cost, portable instrument to personalize dosing for TB treatment or prevention. This article is open access and distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/).PMID:38647526 | DOI:10.1164/rccm.202309-1583OC (Source: Respiratory Care)
Source: Respiratory Care - April 22, 2024 Category: Respiratory Medicine Authors: Renu Verma Kesia Esther da Silva Neesha Rockwood Roeland E Wasmann Nombuso Yende Taeksun Song Eugene Kim Paolo Denti Robert J Wilkinson Jason R Andrews Source Type: research
