Increasing Tuberculosis Rates and Association With Migration in Children Living in Campania Region, Southern Italy: A 10-Year Cohort Study
Background: Italy is classified as a low tuberculosis (TB) incidence country (rate 6.5/100,000 inhabitants). However, the Campania Region Pediatric Reference Centre (CRRC) observed an increase in TB, contemporarily with a rise in migration. Our aim was to investigate trends in TB notification rates, association with migration, and changes in clinical outcomes of children living in Campania. Methods: We conducted a prospective cohort study (January 1, 2009–December 31, 2018), including children (Source: The Pediatric Infectious Disease Journal)
Source: The Pediatric Infectious Disease Journal - October 17, 2020 Category: Infectious Diseases Tags: Original Studies Source Type: research

Completeness of tuberculosis case notifications in Germany in 2013 –2017: first results of an inventory study
Evaluating the completeness of tuberculosis (TB) notification data is important for monitoring of TB surveillance systems. We conducted an inventory study to calculate TB underreporting in Germany in 2013 –2017. (Source: BMC Infectious Diseases)
Source: BMC Infectious Diseases - October 17, 2020 Category: Infectious Diseases Authors: Teresa Domaszewska, Basel Karo, Ute Preuss, Christian Kollan, Annicka Reuss, Hans-Peter Blank, Bonita Brodhun, Barbara Hauer, Doris Altmann, Lena Fiebig, Walter Haas and Nita Perumal Tags: Research article Source Type: research

Knowledge, attitude and practice towards tuberculosis in Gambia: a nation-wide cross-sectional survey
Early diagnosis and treatment of tuberculosis (TB) are the mainstay of global and national TB control efforts. However, the gap between expected and reported cases persists for various reasons attributable to ... (Source: BMC Public Health)
Source: BMC Public Health - October 17, 2020 Category: Consumer Health News Authors: Adedapo Olufemi Bashorun, Christopher Linda, Semeeh Omoleke, Lindsay Kendall, Simon D. Donkor, Ma-Ansu Kinteh, Baba Danso, Lamin Leigh, Sheriff Kandeh, Umberto D ’Alessandro and Ifedayo Morayo O. Adetifa Tags: Research article Source Type: research

Gluteal abscess caused by Mycobacterium tuberculosis
(Source: Techniques in Coloproctology)
Source: Techniques in Coloproctology - October 17, 2020 Category: Surgery Source Type: research

Double trouble: Extrauterine epithelioid trophoblastic tumor with uterine choriocarcinoma - An autopsy report
We report such a case in a 24-year-old woman who presented with menorrhagia since 2 months and obstetric history of two abortions, one of which was a molar pregnancy. She was undergoing evaluation for carcinoma cervix and treatment for pulmonary tuberculosis from another hospital when she was admitted at our institute for further workup and treatment. However, she succumbed and an autopsy was performed. Histologic evaluation after the autopsy revealed uterine choriocarcinoma with metastatic epithelioid trophoblastic tumor (ETT) in the lung and spleen. (Source: Indian Journal of Cancer)
Source: Indian Journal of Cancer - October 17, 2020 Category: Cancer & Oncology Authors: Kusum Jashnani Alshifa Yagana Niraj Mahajan Source Type: research

Stealth Strategies of Mycobacterium tuberculosis for Immune Evasion.
Abstract Tuberculosis is a devastating disease causing high mortality all over the world, especially in the developing countries. Mycobacterium tuberculosis (M. tb) is the causative agent of tuberculosis which replicates in the intracellular environment of host macrophages. Although the host immune system is capable of completely eliminating the pathogen, co-evolution of M. tb with humans has resulted in its ability to hijack the host innate and adaptive immune systems in numerous ways. Limited recent progress has been made in the understanding of M. tb immune escape mechanisms, hence exploration of survival strat...
Source: Current Issues in Molecular Biology - October 17, 2020 Category: Molecular Biology Authors: Naeem MA, Ahmad W, Tyagi R, Akram Q, Younus M, Liu X Tags: Curr Issues Mol Biol Source Type: research

Developing health policies in patients presenting with SARS-CoV-2: consider tuberculosis
Publication date: November 2020Source: The Lancet Global Health, Volume 8, Issue 11Author(s): Karen H Keddy, Giovanni B Migliori, Martie Van Der Walt (Source: The Lancet Global Health)
Source: The Lancet Global Health - October 16, 2020 Category: International Medicine & Public Health Source Type: research

Cytisine for smoking cessation in patients with tuberculosis: a multicentre, randomised, double-blind, placebo-controlled phase 3 trial
Publication date: November 2020Source: The Lancet Global Health, Volume 8, Issue 11Author(s): Omara Dogar, Ada Keding, Rhian Gabe, Anna-Marie Marshall, Rumana Huque, Deepa Barua, Razia Fatima, Amina Khan, Raana Zahid, Sonia Mansoor, Daniel Kotz, Melanie Boeckmann, Helen Elsey, Eva Kralikova, Steve Parrott, Jinshuo Li, Anne Readshaw, Aziz Sheikh, Kamran Siddiqi, TB and Tobacco Consortium (Source: The Lancet Global Health)
Source: The Lancet Global Health - October 16, 2020 Category: International Medicine & Public Health Source Type: research

Video-Assisted Ligation of Intersphincteric Fistula Tract for Complex Anal Fistula: Technique and Preliminary Outcomes
This study aimed to report outcomes of video-assisted ligation of intersphincteric fistula tract (a procedure combining video-assisted anal fistula treatment and ligation of intersphincteric fistula tract) for treating complex anal fistulas and to compare its results with conventional ligation of intersphincteric fistula tract. DESIGN: A review of prospectively collected data from October 2014 to December 2017 was performed. SETTINGS: The study was conducted at a large tertiary hospital in Thailand. PATIENTS: All patients with primary or recurrent complex anal fistulas undergoing video-assisted ligation of intersp...
Source: Diseases of the Colon and Rectum - October 16, 2020 Category: Gastroenterology Tags: Original Contributions: Anorectal Source Type: research

Identification of robust genes in transcriptional regulatory network of Mycobacterium tuberculosis
This study provides a comprehensive analysis of TRN and offers a good basis of understanding for developing experimental study in search of new therapeutic targets against MTB H37Rv pathogen. (Source: IET Systems Biology)
Source: IET Systems Biology - October 16, 2020 Category: Biology Source Type: research

Regulatory role and mechanism of the inhibition of the Mcl-1 pathway during apoptosis and polarization of H37Rv-infected macrophages
Conclusions: We found that Mcl-1 affected the apoptosis and polarization of macrophages infected by Mycobacterium tuberculosis, mainly M1 in the early stage and M2 in the later stage. In addition, mitochondria played a crucial role in this process. (Source: Medicine)
Source: Medicine - October 16, 2020 Category: Internal Medicine Tags: Research Article: Clinical Trial/Experimental Study Source Type: research

[ASAP] An Aptamer Linked Immobilized Sorbent Assay (ALISA) to Detect Circulatory IFN- α, an Inflammatory Protein among Tuberculosis Patients
ACS Combinatorial ScienceDOI: 10.1021/acscombsci.0c00108 (Source: ACS Combinatorial Science)
Source: ACS Combinatorial Science - October 16, 2020 Category: Chemistry Authors: Vibha Taneja, Manish Goel, Uma Shankar, Amit Kumar, Gopi C. Khilnani, Hanumanthappa K. Prasad, Godavari B. K. S. Prasad, Umesh D. Gupta, and Tarun K. Sharma Source Type: research

IJERPH, Vol. 17, Pages 7546: Preventing Occupational Tuberculosis in Health Workers: An Analysis of State Responsibilities and Worker Rights in Mozambique
This study explores how Mozambique’s legal framework and health system governance facilitate—or hinder—implementation of protective measures in its public (state-provided) healthcare sector. Using a mixed-methods approach, we examined international, constitutional, regulatory, and policy frameworks. We also recorded and analysed the content of a workshop and policy discussion group on the topic to elicit the perspectives of health workers and of officials responsible for implementing workplace TB policies. We found that despite a well-developed legal framework and national infectio...
Source: International Journal of Environmental Research and Public Health - October 16, 2020 Category: Environmental Health Authors: Garcia Spiegel Yassi Ehrlich Rom ão A. Nunes Zungu Mabhele Tags: Article Source Type: research

Ambient air pollution and respiratory bacterial infections, a troubling association: epidemiology, underlying mechanisms, and future challenges.
Abstract The World Health Organization attributed more than four million premature deaths to ambient air pollution in 2016. Numerous epidemiologic studies demonstrate that acute respiratory tract infections and exacerbations of pre-existing chronic airway diseases can result from exposure to ambient (outdoor) air pollution. In this context, the atmosphere contains both chemical and microbial pollutants (bioaerosols), whose impact on human health remains unclear. Therefore, this review: summarises the findings from recent studies on the association between exposure to air pollutants-especially particulate matter an...
Source: Critical Reviews in Microbiology - October 16, 2020 Category: Microbiology Authors: Pompilio A, Di Bonaventura G Tags: Crit Rev Microbiol Source Type: research

Nevirapine and tuberculosis predict first-line treatment failure in HIV patients in Indonesia: Case-control study
Publication date: Available online 15 October 2020Source: Annals of Medicine and SurgeryAuthor(s): Yanri W. Subronto, Nur Aini Kusmayanti, Albarisa S. Abdalla, Prenaly D. Sattwika (Source: Annals of Medicine and Surgery)
Source: Annals of Medicine and Surgery - October 15, 2020 Category: General Medicine Source Type: research

How is the microbial diagnosis of bacterial vertebral osteomyelitis performed? An 11-year retrospective study
AbstractVertebral osteomyelitis (VOM) is often diagnosed with delays, resulting in poorer outcomes. Microbial documentation is particularly challenging and obtained using blood cultures (BCs) and vertebral biopsies (VBs; CT-guided or surgical). We retrospectively analysed VOM cases in a tertiary reference centre between 2004 and 2015, focusing on how and how quickly microbiological diagnosis was performed. Among 220 VOM, 88.2% had documentation, including Gram-positive cocci (GPC) (70.6%), Gram-negative rods (GNR) (9.3%), anaerobes (3.6%), polybacterial infections (6.7%) and tuberculosis (9.8%). BCs were performed in 98.2%...
Source: European Journal of Clinical Microbiology and Infectious Diseases - October 15, 2020 Category: Microbiology Source Type: research

Epidemiology of skeletal tuberculosis in Beijing, China: a 10-year retrospective analysis of data
AbstractSkeletal tuberculosis (STB) is one of the most common forms of extrapulmonary tuberculosis; however, limited epidemiological data are available on this public health concern worldwide, especially in developing countries. The aims of this study were to analyze the epidemiological characteristics of STB cases and to identify risk factors associated with drug resistance among STB cases in China. We included STB inpatients at Beijing Chest Hospital from January 2009 through December 2018. The multiple demographic and clinical variables of patients were collected from the hospital ’s electronic patient record. In ...
Source: European Journal of Clinical Microbiology and Infectious Diseases - October 15, 2020 Category: Microbiology Source Type: research

Virtual screening and free energy estimation for identifying Mycobacterium tuberculosis flavoenzyme DprE1 inhibitors
Publication date: January 2021Source: Journal of Molecular Graphics and Modelling, Volume 102Author(s): Niranjan Kumar, Rakesh Srivastava, Amresh Prakash, Andrew M. Lynn (Source: Journal of Molecular Graphics and Modelling)
Source: Journal of Molecular Graphics and Modelling - October 15, 2020 Category: Molecular Biology Source Type: research

Etiopathogenesis, Challenges and Remedies Associated With Female Genital Tuberculosis: Potential Role of Nuclear Receptors
Extra-pulmonary tuberculosis (EPTB) is recognized mainly as a secondary manifestation of a primary tuberculosis (TB) infection in the lungs contributing to a high incidence of morbidity and mortality. The TB bacilli upon reactivation maneuver from the primary site disseminating to other organs. Diagnosis and treatment of EPTB remains challenging due to the abstruse positioning of the infected organs and the associated invasiveness of sample acquisition as well as misdiagnosis, associated comorbidities, and the inadequacy of biomarkers. Female genital tuberculosis (FGTB) represents the most perilous form of EPTB leading to ...
Source: Frontiers in Immunology - October 15, 2020 Category: Allergy & Immunology Source Type: research

Use of T Cell Mediated Immune Functional Assays for Adjustment of Immunosuppressive or Anti-infective Agents in Solid Organ Transplant Recipients: A Systematic Review
Conclusion: Our systematic review supports a promising role for the IGRA-CMVs for adjustment of the duration of anti-CMV antiviral prophylaxis in SOT recipients. There are limited data to support the use of IFAs other than IGRA-CMVs for adjustment of immunosuppressive or anti-infective agents. Further multicenter randomized clinical trials using IFAs other than IGRA-CMVs may help in personalized immunosuppressive or prophylactic anti-infective therapy in SOT recipients. (Source: Frontiers in Immunology)
Source: Frontiers in Immunology - October 15, 2020 Category: Allergy & Immunology Source Type: research

QuantiFERON ®-TB Gold In-Tube test can be used for screening latent tuberculosis before biological treatment in a Bacille Calmette-Guérin (BCG)-vaccinated country: the HUR-BIO single-center real-life results
ConclusionsTBC incidence increased by nearly seven times the Turkish national TBC incidence. The QFT-GIT Test appears acceptable to determine latent TBC before biological agent use. Consequently, the QFT-GIT Test can be appropriately used in BCG-vaccinated countries.Key Points• Our study contributes to filling the gap in the literature by reflecting real-life data about TBC frequency after QFT-GIT use in patients receiving biological agents.•The frequency of active TBC will remain within acceptable limits when only QFT-GIT is used in the screening of latent TBC prior to the use of biological agents in a populatio...
Source: Clinical Rheumatology - October 15, 2020 Category: Rheumatology Source Type: research

Evolution and Conservation of Bordetella Intracellular Survival in Eukaryotic Host Cells
The classical bordetellae possess several partially characterized virulence mechanisms that are studied in the context of a complete extracellular life cycle in their mammalian hosts. Yet, classical bordetellae have repeatedly been reported within dendritic cells (DCs) and alveolar macrophages in clinical samples, and in vitro experiments convincingly demonstrate that the bacteria can survive intracellularly within mammalian phagocytic cells, an ability that appears to have descended from ancestral progenitor species that lived in the environment and acquired the mechanisms to resist unicellular phagocytic predators. Many ...
Source: Frontiers in Microbiology - October 15, 2020 Category: Microbiology Source Type: research

Interpretation of serial interferon-gamma test results to measure new tuberculosis infection among household contacts in Zambia and South Africa
A more stringent QuantiFERON-TB Gold In-Tube (QFT) conversion (from negative to positive) definition has been proposed to allow more definite detection of recent tuberculosis (TB) infection. We explored altern... (Source: BMC Infectious Diseases)
Source: BMC Infectious Diseases - October 15, 2020 Category: Infectious Diseases Authors: Rosa Sloot, Kwame Shanaube, Mareli Claassens, Lily Telisinghe, Ab Schaap, Peter Godfrey-Faussett, Helen Ayles and Sian Floyd Tags: Research article Source Type: research

Pre-HAART CD4+ T-lymphocytes as biomarkers of post-HAART immune recovery in HIV-infected children with or without TB co-infection
Infection with the Human Immunodeficiency Virus (HIV) dramatically increases the risk of developing active tuberculosis (TB). Several studies have indicated that co-infection with TB increases the risk of HIV ... (Source: BMC Infectious Diseases)
Source: BMC Infectious Diseases - October 15, 2020 Category: Infectious Diseases Authors: Vivek Gopalakrishnan, Eliezer Bose, Usha Nair, Yuwei Cheng and Musie Ghebremichael Tags: Research article Source Type: research

Metformin and Rifampicin combination augments active to latent tuberculosis conversion: A Computational Study
This article is protected by copyright. All rights reserved (Source: Biotechnology and Applied Biochemistry)
Source: Biotechnology and Applied Biochemistry - October 15, 2020 Category: Biochemistry Authors: Deepak Yadav, Suman Kamboj, Dibyajyoti Banerjee, Rajasri Bhattacharyya Tags: Original Article Source Type: research

New approaches for antituberculosis leads from Actinobacteria.
Abstract Bioactive metabolites derived from the phylum Actinobacteria represent many of the existing antimicrobial drugs. Compared with other bacterial pathogens, direct preliminary screening by diffusion assays is a limiting factor against Mycobacterium tuberculosis (Mtb) and different methodologies have been used to improve the search for new molecules. However, the concern remains that most of the previously discovered molecules replicate by conventional procedures. However, the combination of multidisciplinary approaches with new technologies could advance the discovery of new leads in bacteria other than Mtb,...
Source: Drug Discovery Today - October 15, 2020 Category: Drugs & Pharmacology Authors: Hussain A, Hassan QP, Shouche YS Tags: Drug Discov Today Source Type: research

Antibacterial activity of new substituted 4-N-alkylated-2-trifluoromethyl-quinoline analogues against sensitive and resistant Mycobacterium tuberculosis strains.
CONCLUSION: These findings contribute to relevant information and perspectives in search of new bioactive compounds against sensitive and resistant TB. Resistant strains have turned tuberculosis a severe disease in the world. PMID: 33069867 [PubMed - as supplied by publisher] (Source: European Journal of Pharmaceutical Sciences)
Source: European Journal of Pharmaceutical Sciences - October 15, 2020 Category: Drugs & Pharmacology Authors: da Silva ET, de Andrade GF, Araújo ADS, Lourenço MCS, de Souza MVN Tags: Eur J Pharm Sci Source Type: research

LncRNA MEG3 control Mycobacterium Tuberculosis infection via controlled MiR-145-5p expression and modulation of macrophages proliferation
Publication date: December 2020Source: Microbial Pathogenesis, Volume 149Author(s): Wen Sun, Hai Lou, Jie Cao, Peng Wang, Qin Sun, Wei Sha (Source: Microbial Pathogenesis)
Source: Microbial Pathogenesis - October 14, 2020 Category: Infectious Diseases Source Type: research

Probability of mycobactericidal activity of para-aminosalicylic acid with novel dosing regimens
ConclusionThe pharmacokinetic/pharmacodynamic parameters linked to bactericidal activity should be determined for 14  g, 16 g and 20 g once-daily doses of PASER. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - October 14, 2020 Category: Drugs & Pharmacology Source Type: research

Adaptation Allowing for Bronchial Blocker Proximal Port Filtration during Lung Isolation for Patients with Airborne Precautions
AIRBORNE precautions are recommended in patients with bacterial and viral infections transferredvia aerosolization (includingMycobacterium tuberculosis, rubeola, varicella, influenza and coronavirus disease 2019 [COVID-19]). Surgical procedures requiring lung isolation during airborne precautions require adaptations to limit environmental contamination.1 (Source: Anesthesiology)
Source: Anesthesiology - October 14, 2020 Category: Anesthesiology Source Type: research

A Direct Role for the CD1b Endogenous Spacer in the Recognition of a Mycobacterium tuberculosis Antigen by T-Cell Receptors
Lipids, glycolipids and lipopeptides derived from Mycobacterium tuberculosis (Mtb) are presented to T cells by monomorphic molecules known as CD1. This is the case of the Mtb-specific sulfoglycolipid Ac2SGL, which is presented by CD1b molecules and is recognized by T cells found in tuberculosis (TB) patients and in individuals with latent infections. Our group, using filamentous phage display technology, obtained two specific ligands against the CD1b-Ac2SGL complex: (i) a single chain T cell receptor (scTCR) from a human T cell clone recognizing the CD1b-AcSGL complex; and (ii) a light chain domain antibody (dAbκ11)....
Source: Frontiers in Immunology - October 14, 2020 Category: Allergy & Immunology Source Type: research

A Retrospective Cohort Study of Coexistence of Carcinoma and Tuberculosis of Colon: 12-Year Experience
AbstractCoexistence of carcinoma colon and tuberculosis is rare. The aim of this study is to present our 12-year experience on colonic carcinoma with coexisting colonic TB. Histopathology and imaging records of 189 patients of colonic carcinoma patients who underwent treatment in surgical unit 6 in our institute between January 2006 and December 2017 were reviewed. In 7 patients, histopathology and/or imaging studies were suggestive of coexistence of colonic carcinoma and tuberculosis. Fifteen cases of colonic tuberculosis were also reviewed. Descriptive statistics were used to summarize the data. Colonoscopic biopsy was s...
Source: Indian Journal of Surgical Oncology - October 14, 2020 Category: Cancer & Oncology Source Type: research

IJERPH, Vol. 17, Pages 7483: Prevalence and Economic Burden of Respiratory Diseases in Central Asia and Russia: A Systematic Review
van Boven Prevalence data of respiratory diseases (RDs) in Central Asia (CA) and Russia are contrasting. To inform future research needs and assist government and clinical policy on RDs, an up-to-date overview is required. We aimed to review the prevalence and economic burden of RDs in CA and Russia. PubMed and EMBASE databases were searched for studies that reported prevalence and/or economic burden of RDs (asthma, chronic obstructive pulmonary disease (COPD), cystic fibrosis, interstitial lung diseases (ILD), lung cancer, pulmonary hypertension, and tuberculosis (TB)) in CA (Kyrgyzstan, Uzbekistan, Tajikistan, Kaz...
Source: International Journal of Environmental Research and Public Health - October 14, 2020 Category: Environmental Health Authors: Tabyshova Emilov Postma Chavannes Sooronbaev van Boven Tags: Review Source Type: research

One-stage posterior debridement and single-segment interbody fusion for treating mono-segmental lumbar and lumbosacral spinal tuberculosis in adults following minimum 5-year follow-up
To evaluate the mid-long-term outcomes of surgical management of mono-segmental lumbar and lumbosacral spinal tuberculosis (TB) in adults by one-stage posterior debridement, single-segment fixation, and titani... (Source: Journal of Orthopaedic Surgery and Research)
Source: Journal of Orthopaedic Surgery and Research - October 14, 2020 Category: Orthopaedics Authors: Zhenchao Xu, Xiyang Wang and Zheng Liu Tags: Research article Source Type: research

Detection of Beijing strains of MDR M. tuberculosis and their association with drug resistance mutations in katG, rpoB, and embB genes
Molecular epidemiological studies of Mycobacterium tuberculosis (MTB) are the core of current research to find out the association of the M. tuberculosis genotypes with its outbreak and transmission. The high pre... (Source: BMC Infectious Diseases)
Source: BMC Infectious Diseases - October 14, 2020 Category: Infectious Diseases Authors: Anamika Gupta, Pallavi Sinha, Vijay Nema, Pramod K. Gupta, Pampi Chakraborty, Savita Kulkarni, Nalin Rastogi and Shampa Anupurba Tags: Research article Source Type: research

Molecular epidemiology of clinical Mycobacterium tuberculosis complex isolates in South Omo, Southern Ethiopia
Tuberculosis (TB) is caused by Mycobacterium tuberculosis complex (MTBC). Mapping the genetic diversity of MTBC in high TB burden country like Ethiopia is important to understand principles of the disease transmi... (Source: BMC Infectious Diseases)
Source: BMC Infectious Diseases - October 13, 2020 Category: Infectious Diseases Authors: Biniam Wondale, Kwon Keehwan, Girmay Medhin, Takele Teklu, Temesgen Mohammed, Samuel Tolosa, Aboma Zewude, Friehiwot Amsalu, Rembert Pieper and Gobena Ameni Tags: Research article Source Type: research

Costal tubercular osteomyelitis presenting as an orbital abscess.
Abstract Orbital abscesses are most commonly associated with co-existing active paranasal sinus infection. Herein, the authors present the case of an orbital abscess in the setting of costal tubercular osteomyelitis and an anterior chest wall abscess in the absence of any paranasal sinus pathology in an immunocompetent patient. Costal tuberculosis is a very rare form of extrapulmonary skeletal tuberculosis and is challenging to diagnose. Initial presentation as an orbital abscess remote from the site of the primary pathology is of extremely rare occurrence. In this instance, the diagnosis of tuberculous osteomyeli...
Source: Orbit - October 13, 2020 Category: Opthalmology Authors: Pattnaik M, Tripathy D Tags: Orbit Source Type: research

Identification of B cell antigenome in Mycobacterium bovis by immunoproteomic analysis.
In this study, the B cell antigenome of culture filtrate proteins (CFP) was defined by mass spectrometry-based proteomics technology. Four spots were detected on 2-dimensional gel electrophoresis (2-DE) against M. bovis-positive serum in an immunoblotting experiment. Twenty-one proteins were identified in four spots by proteomic tools, such as Mb2900, Mb2898, Mb0448, Mb3834c, Mb1918c, Mb0134c, Mb0358 and Mb1868c, which are known B cell antigens, including 13 new proteins, i.e. Mb3751, Mb2006c, Mb3276c, Mb2244, Mb1164c, Mb2553c, Mb2946c, Mb1849c, Mb1511c, Mb1034c, Mb2616c, Mb0854c and Mb2267. These new proteins identified b...
Source: Acta Veterinaria Hungarica - October 13, 2020 Category: Veterinary Research Authors: Cho YS, Lee SE, Jang Y, Jung S, Kim JM Tags: Acta Vet Hung Source Type: research

Tuberculosis heralding connective tissue disorder.
We report such a case. A 50-year-old diabetic male, a roadside shop keeper, a current smoker presented with fever, breathlessness, cough and weight loss for four months. Chest radiography demonstrated areas of consolidation with halo signs. Anti-nuclear antibody blot was positive for Scl-70 and Jo-1 suggestive of a syndrome of systemic sclerosis and polymyositis overlap. Fibre-optic bronchoscopy guided lung biopsy was suggestive of organising pneumonia, and broncho-alveolar lavage detected Mycobacterium tuberculosis. Mycobacterium tuberculosis should be investigated as an aetiology of organising pneumonia, as this may occu...
Source: Tropical Doctor - October 13, 2020 Category: Tropical Medicine Authors: Pratap U, Ravindrachari M, RamyaPriya A, Toi PC, Manju R Tags: Trop Doct Source Type: research

Integrative genomics analysis identifies promising SNPs and genes implicated in tuberculosis risk based on multiple omics datasets.
Abstract More than 10 GWASs have reported numerous genetic loci associated with tuberculosis (TB). However, the functional effects of genetic variants on TB remains largely unknown. In the present study, by combining a reported GWAS summary dataset (N = 452,264) with 3 independent eQTL datasets (N = 2,242) and other omics datasets downloaded from public databases, we conducted an integrative genomics analysis to highlight SNPs and genes implicated in TB risk. Based on independent biological and technical validations, we prioritized 26 candidate genes with eSNPs significantly associated with gene expression and TB ...
Source: Aging - October 13, 2020 Category: Biomedical Science Authors: Xu M, Li J, Xiao Z, Lou J, Pan X, Ma Y Tags: Aging (Albany NY) Source Type: research

Male genital tract tuberculosis: A  comprehensive review of imaging findings and differential diagnosis
AbstractUrogenital tuberculosis is the most common form of extrapulmonary tuberculosis. Genital organ involvement occurs as a continuum of urinary tract tuberculosis and often presents a diagnostic challenge due to the non-specific nature of the symptoms. Delay in diagnosis may lead to complications such as infertility and perineoscrotal sinuses. Imaging plays an important role in raising timely suspicion of tuberculosis. In this article, we describe the imaging findings of male genital tuberculosis and the differential diagnosis. High-resolution ultrasonography (HRUS) is the best modality for assessing the epididymis, tes...
Source: Abdominal Imaging - October 12, 2020 Category: Radiology Source Type: research

Adults from Kisumu, Kenya have robust γδ T cell responses to < i > Schistosoma mansoni < /i > , which are modulated by tuberculosis
by Taryn A. McLaughlin, Jeremiah Khayumbi, Joshua Ongalo, Daniel Matete, Joan Tonui, Benson Muchiri, Loren E. Sasser, Angela Campbell, Salim Allana, Samuel Gurrion Ouma, Felix Odhiambo Hayara, Neel R. Gandhi, Cheryl L. DaySchistosoma mansoni (SM) is a parasitic helminth that infects over 200 million people and causes severe morbidity. It undergoes a multi-stage life cycle in human hosts and as such stimulates a stage-specific immune response. The human T cell response to SM is complex and varies throughout the life cycle of SM. Relative to the wealth of information regarding the immune response to SM eggs, little is known ...
Source: PLoS Neglected Tropical Diseases - October 12, 2020 Category: Tropical Medicine Authors: Taryn A. McLaughlin Source Type: research

Implementing contact tracing for tuberculosis in Kyrgyz Republic and risk factors for positivity using QuantiFERON-TB Gold plus
Effective active case finding (ACF) activities are essential for early identification of new cases of active tuberculosis (TB) and latent TB infection (LTBI). Accurate diagnostics as well as the ability to ide... (Source: BMC Infectious Diseases)
Source: BMC Infectious Diseases - October 12, 2020 Category: Infectious Diseases Authors: Caroline Corbett, Aizat Kulzhabaeva, Tatjana Toichkina, Gulmira Kalmambetova, Sevim Ahmedov, Uladzimir Antonenka, Altyn Iskakova, Dilorom Kosimova, Dasha Migunov, Bakyt Myrzaliev, Evgeni Sahalchyk, Nagira Umetalieva, Monica Vogel, Abdylat Kadyrov and Hara Tags: Research article Source Type: research

Disparate effects of metformin on Mycobacterium tuberculosis infection in diabetic and non-diabetic mice.
Abstract Comorbid type 2 diabetes poses a great challenge to the global control of tuberculosis. Here we assessed the efficacy of metformin (MET); an anti-diabetic drug, in mice infected with a very-low dose of Mycobacterium tuberculosis In contrast to diabetic mice, infected non-diabetic mice that received the same therapeutic concentration of MET presented with significantly higher disease burden. This warrants further studies to investigate the disparate efficacy of MET against tuberculosis in diabetic and non-diabetic individuals. PMID: 33046495 [PubMed - as supplied by publisher] (Source: Antimicrobial A...
Source: Antimicrobial Agents and Chemotherapy - October 12, 2020 Category: Microbiology Authors: Sathkumara HD, Hansen K, Miranda-Hernandez S, Govan B, Rush CM, Henning L, Ketheesan N, Kupz A Tags: Antimicrob Agents Chemother Source Type: research

Treatment outcomes and adverse drug effects of ethambutol, cycloserine and terizidone for treatment of multi-drug resistant tuberculosis in South Africa.
Abstract Background: Treatment outcomes among MDR-TB patients receiving ethambutol, cycloserine or terizidone as part of a standardized regimen were compared, determining occurrence of serious adverse drug events (SADEs).Methods: Newly-diagnosed adult MDR-TB patients were enrolled between 2000 and 2004, receiving a standardised multidrug regimen for 18-24 months, including ethambutol, cycloserine or terizidone. Cycloserine and terizidone were recorded individually. SADEs and factors associated with culture conversion and unfavourable treatment outcomes (default, death, treatment failure) were determined.Results: O...
Source: Antimicrobial Agents and Chemotherapy - October 12, 2020 Category: Microbiology Authors: van der Walt ML, Shean K, Becker P, Keddy KH, Lancaster J Tags: Antimicrob Agents Chemother Source Type: research

Mycobacterium tuberculosis extracellular vesicles: exploitation for vaccine technology and diagnostic methods.
Abstract Tuberculosis (TB) is a fatal epidemic disease usually caused by Mycobacterium tuberculosis (Mtb). Pervasive latent infection, multidrug- and extensively drug-resistant tuberculosis (MDR- and XDR-TB), and TB/HIV co-infection make TB a global health problem, which emphasises the design and development of efficient vaccines and diagnostic biomarkers. Extracellular vesicles (EVs) secretion is a conserved phenomenon in all the domains of life. Various cargos such as nucleic acids, toxins, lipoproteins, and enzymes have been recognised in these nano-sized vesicles that may be involved in bacterial physiology an...
Source: Critical Reviews in Microbiology - October 12, 2020 Category: Microbiology Authors: Mohammadzadeh R, Ghazvini K, Farsiani H, Soleimanpour S Tags: Crit Rev Microbiol Source Type: research

Tuberculosis Treatment Facilitated by Lipid Nanocarriers: Can Inhalation Improve the Regimen?
ASSAY and Drug Development Technologies,Volume 18, Issue 7, Page 298-307, October 2020. (Source: ASSAY and Drug Development Technologies)
Source: ASSAY and Drug Development Technologies - October 12, 2020 Category: Drugs & Pharmacology Authors: Gabriela H ädrich Raphael Aparecido Boschero Arthur Sperry Appel Mariana Falkembach Matheus Monteiro Pedro Eduardo Almeida da Silva Lea Ann Dailey Cristiana Lima Dora Source Type: research

Lipolytic enzymes inhibitors: A new way for antibacterial drugs discovery.
Abstract Tuberculosis (TB) caused by Mycobacterium tuberculosis (M. tb) still remains the deadliest infectious disease worldwide with 1.5 million deaths in 2018, of which about 15% are attributed to resistant strains. Another significant example is Mycobacterium abscessus (M. abscessus), a nontuberculous mycobacteria (NTM) responsible for cutaneous and pulmonary infections, representing up to 95% of NTM infections in cystic fibrosis (CF) patients. M. abscessus is a new clinically relevant pathogen and is considered one of the most drug-resistant mycobacteria for which standardized chemotherapeutic r...
Source: European Journal of Medicinal Chemistry - October 12, 2020 Category: Chemistry Authors: Cavalier JF, Spilling CD, Durand T, Camoin L, Canaan S Tags: Eur J Med Chem Source Type: research

Miliary tuberculosis secondary to intravesical instillation of Bacillus Calmette-Gu érin. Report of two cases.
Miliary tuberculosis secondary to intravesical instillation of Bacillus Calmette-Guérin. Report of two cases. Med Mal Infect. 2020 Oct 07;: Authors: Gálvez-López R, Ruiz-Carazo E, Láinez-Ramos-Bossini AJ, Salguero AJG, García CP PMID: 33038446 [PubMed - as supplied by publisher] (Source: Medecine et Maladies Infectieuses)
Source: Medecine et Maladies Infectieuses - October 11, 2020 Category: Infectious Diseases Tags: Med Mal Infect Source Type: research

TREM-1 enhances Mycobacterium tuberculosis-induced inflammatory responses in macrophages
Publication date: Available online 10 October 2020Source: Microbes and InfectionAuthor(s): Jia-Yih Feng, Wei-Juin Su, Fan-Yi Chuang, Sheng-Wei Pan, Yi-Chen Yeh, Yung-Yang Lin, Nien-Jung Chen (Source: Microbes and Infection)
Source: Microbes and Infection - October 11, 2020 Category: Infectious Diseases Source Type: research