A Nanopore Sequencing-based Pharmacogenomic Panel to Personalize Tuberculosis Drug Dosing
CONCLUSION: Targeted sequencing can enable detection of polymorphisms influencing TB drug metabolism on a low-cost, portable instrument to personalize dosing for TB treatment or prevention. This article is open access and distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/).PMID:38647526 | DOI:10.1164/rccm.202309-1583OC (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - April 22, 2024 Category: Respiratory Medicine Authors: Renu Verma Kesia Esther da Silva Neesha Rockwood Roeland E Wasmann Nombuso Yende Taeksun Song Eugene Kim Paolo Denti Robert J Wilkinson Jason R Andrews Source Type: research
Another Step Closer to Genomic-informed Therapeutic Dosing for Tuberculosis Drugs
Am J Respir Crit Care Med. 2024 Apr 22. doi: 10.1164/rccm.202403-0566ED. Online ahead of print.NO ABSTRACTPMID:38648185 | DOI:10.1164/rccm.202403-0566ED (Source: Respiratory Care)
Source: Respiratory Care - April 22, 2024 Category: Respiratory Medicine Authors: Paul K Drain Source Type: research
A Nanopore Sequencing-based Pharmacogenomic Panel to Personalize Tuberculosis Drug Dosing
CONCLUSION: Targeted sequencing can enable detection of polymorphisms influencing TB drug metabolism on a low-cost, portable instrument to personalize dosing for TB treatment or prevention. This article is open access and distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/).PMID:38647526 | DOI:10.1164/rccm.202309-1583OC (Source: Respiratory Care)
Source: Respiratory Care - April 22, 2024 Category: Respiratory Medicine Authors: Renu Verma Kesia Esther da Silva Neesha Rockwood Roeland E Wasmann Nombuso Yende Taeksun Song Eugene Kim Paolo Denti Robert J Wilkinson Jason R Andrews Source Type: research
A Nanopore Sequencing-based Pharmacogenomic Panel to Personalize Tuberculosis Drug Dosing
CONCLUSION: Targeted sequencing can enable detection of polymorphisms influencing TB drug metabolism on a low-cost, portable instrument to personalize dosing for TB treatment or prevention. This article is open access and distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/).PMID:38647526 | DOI:10.1164/rccm.202309-1583OC (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - April 22, 2024 Category: Intensive Care Authors: Renu Verma Kesia Esther da Silva Neesha Rockwood Roeland E Wasmann Nombuso Yende Taeksun Song Eugene Kim Paolo Denti Robert J Wilkinson Jason R Andrews Source Type: research
Another Step Closer to Genomic-informed Therapeutic Dosing for Tuberculosis Drugs
Am J Respir Crit Care Med. 2024 Apr 22. doi: 10.1164/rccm.202403-0566ED. Online ahead of print.NO ABSTRACTPMID:38648185 | DOI:10.1164/rccm.202403-0566ED (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - April 22, 2024 Category: Intensive Care Authors: Paul K Drain Source Type: research
A case of disseminated nocardiosis with orbital apex involvement and endophthalmitis
We report a case of disseminated nocardiosis with orbital apex involvement and endophthalmitis in an immunocompromised patient. The patient presented with respiratory sepsis, and later developed complete ptosis and ophthalmoplegia in the left eye. This was on the background of treatment with high-dose prednisolone. Magnetic resonance imaging showed enhancement of the entire clivus, extending into the left orbital apex and cavernous sinus. The patient was initially treated empirically for CNS tuberculosis. Bronchoscopic cultures returned positive for Nocardia farcinica, and the patient was treated with trimethoprim/sulfamet...
Source: Orbit - April 22, 2024 Category: Opthalmology Authors: Reema Madike Khizar Rana Sandy Patel Dinesh Selva Source Type: research
Vigilance Needed in Treating a Child with Disseminated TB: A Case Report
CONCLUSION: The diagnosis of tuberculosis in children is difficult because of the mild, nonspe-cific clinical presentation, which usually reflects the implicated underlying organ. In addition to prompt diagnosis and treatment of disseminated TB, careful monitoring is equally important.PMID:38644704 | DOI:10.2174/0118715265287146240405075930 (Source: Infectious Disorders Drug Targets)
Source: Infectious Disorders Drug Targets - April 22, 2024 Category: Infectious Diseases Authors: Hemasri Velmurugan Krishnapriya Neelambaran Meenalotchini Prakash Gurunthalingam Dushyant Chouhan Pugazhenthan Thangaraju Bikram Keshari Kar Nitin Rewaram Gaikwad Source Type: research
Third Generation Solid Dispersion-Based Formulation of Novel Anti-Tubercular Agent Exhibited Improvement in Solubility, Dissolution and Biological Activity
AbstractThe long treatment period and development of drug resistance in tuberculosis (TB) necessitates the discovery of new anti-tubercular agents. The drug discovery program of the institute leads to the development of an anti-tubercular lead (IIIM-019), which is an analogue of nitrodihydroimidazooxazole and exhibited promising anti-tubercular action. However, IIIM-019 displays poor aqueous solubility (1.2 µg/mL), which demands suitable dosage form for its efficient oral administration. In the present study, third generation solid dispersion-based formulation was developed to increase the solubility and dissolution of ...
Source: The AAPS Journal - April 22, 2024 Category: Drugs & Pharmacology Source Type: research
Patterns And Outcomes In Pediatric Abdominal Tuberculosis: A Single Centre Cohort Study
Abdominal tuberculosis presents in a variety of ways. Different testing modalities must be applied in addition to having a high clinical suspicion to diagnose and initiate therapy. Medications have a good response; however, morbidity has been seen following surgical management of complicated presentations like intestinal obstruction and perforation. There is a paucity of studies in the pediatric age group which evaluate response to the different treatment regimen and identify factors associated with poorer outcomes in children with abdominal tuberculosis. (Source: Journal of Pediatric Surgery)
Source: Journal of Pediatric Surgery - April 22, 2024 Category: Surgery Authors: Susan John, Dhruva Ghosh, Vishal Michael, Deirdre Kruger, Ritu Jain, Karan Dhir, Sangeetha Mohan, Aneel Bhangu Source Type: research
Early diagnosis of tuberculous peritonitis in peritoneal dialysis patients using the T-SPOT test
AbstractA 49-year-old man was admitted with peritonitis nine months after starting continuous ambulatory peritoneal dialysis (CAPD) for kidney failure. Ceftazidime and cefazolin were started. Peritoneal dialysate culture was negative for bacteria, but antibiotic treatment was continued because peritonitis improved. Twenty days later, the patient was discharged with no signs of peritonitis. However, 40-day culture of the original peritoneal dialysate detectedMycobacterium tuberculosis, and peritonitis recurred, leading to readmission. A T-SPOT test was performed and was positive in 4 days. Anti-tuberculosis therapy was st...
Source: CEN Case Reports - April 21, 2024 Category: Urology & Nephrology Source Type: research
Interpretable machine learning in predicting drug-induced liver injury among tuberculosis patients: model development and validation study
The objective of this research was to create and validate an interpretable prediction model for drug-induced liver injury (DILI) during tuberculosis (TB) treatment. (Source: BMC Medical Research Methodology)
Source: BMC Medical Research Methodology - April 20, 2024 Category: Research Authors: Yue Xiao, Yanfei Chen, Ruijian Huang, Feng Jiang, Jifang Zhou and Tianchi Yang Tags: Research Source Type: research
GenoMycAnalyzer: a web-based tool for species and drug resistance prediction for Mycobacterium genomes
Drug-resistant tuberculosis (TB) is a major threat to global public health. Whole-genome sequencing (WGS) is a useful tool for species identification and drug resistance prediction, and many clinical laborator... (Source: BMC Genomics)
Source: BMC Genomics - April 20, 2024 Category: Genetics & Stem Cells Authors: Doyoung Kim, Jeong-Ih Shin, In Young Yoo, Sungjin Jo, Jiyon Chu, Woo Young Cho, Seung-Hun Shin, Yeun-Jun Chung, Yeon-Joon Park and Seung-Hyun Jung Tags: Software Source Type: research
Death after cure: mortality among pulmonary tuberculosis survivors in rural Uganda
This study aimed to determine the incidence and predictors of mortality among TB survivors at a rural tertiary hospital in Uganda. (Source: International Journal of Infectious Diseases)
Source: International Journal of Infectious Diseases - April 20, 2024 Category: Infectious Diseases Authors: Joseph Baruch Baluku, Brenda Namanda, Sharon Namiiro, Diana Karungi Rwabwera, Gloria Mwesigwa, Catherine Namaara, Bright Twinomugisha, Isabella Nyirazihawe, Edwin Nuwagira, Grace Kansiime, Enock Kizito, Mary G. Nabukenya-Mudiope, Moorine Penninah Sekadde, Tags: Short Communication Source Type: research
Transcriptional activation of the Mycobacterium tuberculosis virulence ‐associated small RNA MTS1338 by the response regulators DosR and PhoP
MTS1338 is an infection-induced small RNA found in pathogenic mycobacterial strains. It is highly accumulated in response to numerous stresses. Herein, we investigated how MTS1338 is regulated at the transcriptional level. Our findings reveal the interplay of DosR (a mycobacterial dormancy regulator) and PhoP (which regulates low pH-inducible genes) at the promoter region of theMTS1338 gene during transcriptional activation. MTS1338, a distinctive small RNA in pathogenic mycobacteria, plays a crucial role in host –pathogen interactions during infection. Mycobacterial cells encounter heterogeneous stresses in macrophages,...
Source: FEBS Letters - April 19, 2024 Category: Biochemistry Authors: Krishan Kumar,
Tanmay Dutta Tags: Research Letter Source Type: research
Genomic Interactions Between < em > Mycobacterium tuberculosis < /em > and Humans
Annu Rev Genomics Hum Genet. 2024 Apr 19. doi: 10.1146/annurev-genom-021623-101844. Online ahead of print.ABSTRACTMycobacterium tuberculosis is considered by many to be the deadliest microbe, with the estimated annual cases numbering more than 10 million. The bacteria, including Mycobacterium africanum, are classified into nine major lineages and hundreds of sublineages, each with different geographical distributions and levels of virulence. The phylogeographic patterns can be a result of recent and early human migrations as well as coevolution between the bacteria and various human populations, which may explain why many ...
Source: Annual Review of Genomics and Human Genetics - April 19, 2024 Category: Genetics & Stem Cells Authors: Prasit Palittapongarnpim Pornpen Tantivitayakul Pakorn Aiewsakun Surakameth Mahasirimongkol Bharkbhoom Jaemsai Source Type: research
