Organ Doses from Chest Radiographs in Tuberculosis Patients in Canada and Their Uncertainties in Periods from 1930 to 1969
This paper describes a study to estimate absorbed doses to various organs from film-based chest radiographs and their uncertainties in the periods 1930 to 1948, 1949 to 1955, and 1956 to 1969. Estimated organ doses will be used in new analyses of risks of cancer and other diseases in tuberculosis patients in Canada who had chest fluoroscopic and radiographic examinations in those periods. In this paper, doses to lungs, female breast, active bone marrow, and heart from a single chest radiograph in adults and children of ages 1, 5, 10, and 15 y in the Canadian cohort and their uncertainties are estimated using (1) data on th...
Source: Health Physics - July 30, 2020 Category: Radiology Tags: PAPERS Source Type: research

Primary Epiphyseal Osteomyelitis (PEO) in 18 Children: A Rare Entity With Atypical Features
Conclusion: High index of suspicion is required for early diagnosis of PEO. It is important to differentiate Tubercular from other bacterial PEO as it has more subtle symptoms and poor prognosis if left untreated. Aggressive surgical treatment followed by antibiotic therapy of appropriate duration is required to avoid complications related to joint destruction. To our knowledge, this is the largest reported series with longest follow-up. (Source: Journal of Pediatric Orthopaedics)
Source: Journal of Pediatric Orthopaedics - July 30, 2020 Category: Orthopaedics Tags: Selected Item Source Type: research

Tuberculosis screening update
No abstract available (Source: Nursing)
Source: Nursing - July 30, 2020 Category: Nursing Tags: Department: INFECTION PREVENTION Source Type: research

Determining standardized causes of death of infants, children, and adolescents living with HIV in Asia
Conclusion: Our standardized cause of death assessment provides robust data to inform regional resource allocation for pediatric diagnostic evaluations and prioritization of clinical interventions, and highlight the continued importance of opportunistic and nonopportunistic infections as causes of death in our cohort. (Source: AIDS)
Source: AIDS - July 30, 2020 Category: Infectious Diseases Tags: EPIDEMIOLOGY AND SOCIAL Source Type: research

Recurrent Tuberculosis in a Young Child
We present the first case of proven tuberculosis reinfection in a likely immunocompetent child, living in a high-risk environment favorable for exposition to M. tuberculosis but in a low-incidence country. (Source: The Pediatric Infectious Disease Journal)
Source: The Pediatric Infectious Disease Journal - July 30, 2020 Category: Infectious Diseases Tags: Brief Reports Source Type: research

Challenging diagnosis of gastrointestinal tuberculosis made simpler with multi-targeted loop-mediated isothermal amplification assay
Conclusion Multi-targeted LAMP is a promising technique for rapid and accurate diagnosis of GITB. (Source: European Journal of Gastroenterology and Hepatology)
Source: European Journal of Gastroenterology and Hepatology - July 30, 2020 Category: Gastroenterology Tags: Original Articles: Gastroenterology Source Type: research

Clinical characteristics of COVID-19 and active tuberculosis co-infection in an Italian reference hospital
Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), emerged in Wuhan, China, in December 2019. In February 2020, an outbreak was detected in the Lombardy region of Italy, resulting in the first major outbreak outside Asia [1]. (Source: European Respiratory Journal)
Source: European Respiratory Journal - July 29, 2020 Category: Respiratory Medicine Authors: Stochino, C., Villa, S., Zucchi, P., Parravicini, P., Gori, A., Raviglione, M. C. Tags: Original Articles: Research letters Source Type: research

Tuberculosis Infection in Children
Globally, tuberculosis (TB) is the leading cause of infectious disease mortality; however, clinicians in the United States are increasingly unfamiliar with TB and the recommended tests and treatment for latent TB infection. Compared with adults, children who develop TB more often develop severe disease, and children (Source: The Journal for Nurse Practitioners)
Source: The Journal for Nurse Practitioners - July 29, 2020 Category: Nursing Authors: Rebekah J. Stewart, Jonathan Wortham, Farah Parvez, Sapna Bamrah Morris, Hannah L. Kirking, Lindsay Hatzenbuehler Cameron, Andrea T. Cruz Tags: Featured Article Source Type: research

Common concerns in managing bronchial asthma during the COVID-19 pandemic
(Source: International Journal of Tuberculosis and Lung Disease)
Source: International Journal of Tuberculosis and Lung Disease - July 29, 2020 Category: Respiratory Medicine Authors: Chai, C-S. Liam, C-K. Tags: LETTERS Source Type: research

How should body mass index inform active tuberculosis screening in diabetes clinics in Asia?
(Source: International Journal of Tuberculosis and Lung Disease)
Source: International Journal of Tuberculosis and Lung Disease - July 29, 2020 Category: Respiratory Medicine Authors: Kubiak, R. W. Drain, P. K. Hochberg, N. S. Tags: CORRESPONDENCE Source Type: research

Improved detection of previously undetectable mycobacteria grown in liquid culture
(Source: International Journal of Tuberculosis and Lung Disease)
Source: International Journal of Tuberculosis and Lung Disease - July 29, 2020 Category: Respiratory Medicine Authors: Subramanyam, B. Sivaramakrishnan, G. Dhandapani, R. Sangamithrai, D. Sivaraman, P. Dinesh, V. Thiruvengadam, K. Golla, R. Nagarajan, P. Mondal, R. Tags: CORRESPONDENCE Source Type: research

Transforming essential services for tuberculosis during the COVID-19 pandemic: lessons from New York City
(Source: International Journal of Tuberculosis and Lung Disease)
Source: International Journal of Tuberculosis and Lung Disease - July 29, 2020 Category: Respiratory Medicine Authors: Burzynski, J. Macaraig, M. Nilsen, D. Schluger, N. W. Tags: LETTERS Source Type: research

Rapid development of a novel portable negative pressure device
(Source: International Journal of Tuberculosis and Lung Disease)
Source: International Journal of Tuberculosis and Lung Disease - July 29, 2020 Category: Respiratory Medicine Authors: Haas, N. L. Bassin, B. S. Kota, S. Puls, H. A. Hyzy, R. C. Napolitano, L. M. Blank, R. McSparron, J. I. Kota, S. S. Ward, K. R. Tags: LETTERS Source Type: research

Rapid development of a portable negative pressure procedural tent
(Source: International Journal of Tuberculosis and Lung Disease)
Source: International Journal of Tuberculosis and Lung Disease - July 29, 2020 Category: Respiratory Medicine Authors: Bassin, B. S. Haas, N. L. Puls, H. A. Kota, S. Kota, S. S. Ward, K. R. Tags: LETTERS Source Type: research

COVID-19 in Africa: preparing for the storm
(Source: International Journal of Tuberculosis and Lung Disease)
Source: International Journal of Tuberculosis and Lung Disease - July 29, 2020 Category: Respiratory Medicine Authors: Chakaya, J. Binegdie, A. Irungu, A. Pearson, B. Gray, D. Zar, H. J. Schewitz, I. Kagima, J. Mortimer, K. Ozoh, O. B. Masekela, R. Gordon, S. B. Worodria, W. Aluoch, J. Tags: LETTERS Source Type: research

Severe COVID-19 cases with a history of active or latent tuberculosis
(Source: International Journal of Tuberculosis and Lung Disease)
Source: International Journal of Tuberculosis and Lung Disease - July 29, 2020 Category: Respiratory Medicine Authors: Liu, C. Yu, Y. Fleming, J. Wang, T. Shen, S. Wang, Y. Fan, L. Ma, J. Gu, Y. Chen, Y. Tags: LETTERS Source Type: research

Willingness to accept reimbursement for visits to an HIV clinic for tuberculosis preventive therapy
(Source: International Journal of Tuberculosis and Lung Disease)
Source: International Journal of Tuberculosis and Lung Disease - July 29, 2020 Category: Respiratory Medicine Authors: Kadota, J. L. Katamba, A. Musinguzi, A. Welishe, F. Nabunje, J. Ssemata, J. L. Berger, C. A. Kamya, M. R. Namusobya, J. Semitala, F. C. Cattamanchi, A. Dowdy, D. W. Tags: LETTERS Source Type: research

Bacille Calmette-Gu érin (BCG) vaccine and the COVID-19 pandemic: responsible stewardship is needed
(Source: International Journal of Tuberculosis and Lung Disease)
Source: International Journal of Tuberculosis and Lung Disease - July 29, 2020 Category: Respiratory Medicine Authors: Schaaf, H. S. du Preez, K. Kruger, M. Solomons, R. Taljaard, J. J. Rabie, H. Seddon, J. A. Cotton, M. F. Tebruegge, M. Curtis, N. Hesseling, A. C. Tags: LETTERS Source Type: research

Diagnostic code agreement for electronic health records and claims data for tuberculosis
(Source: International Journal of Tuberculosis and Lung Disease)
Source: International Journal of Tuberculosis and Lung Disease - July 29, 2020 Category: Respiratory Medicine Authors: Iqbal, S. A. Isenhour, C. J. Mazurek, G. Truman, B. I. Tags: ORIGINAL ARTICLES Source Type: research

Effects of comorbidities on quality of life in Filipino people with tuberculosis
(Source: International Journal of Tuberculosis and Lung Disease)
Source: International Journal of Tuberculosis and Lung Disease - July 29, 2020 Category: Respiratory Medicine Authors: Edwards, T. White, L. V. Lee, N. Castro, M. C. Saludar, N. R. Faguer, B. N. Fuente, N. D. Mayoga, F. Ariyoshi, K. Garfin, A. M. C. G. Solon, J. A. Cox, S. E. Tags: ORIGINAL ARTICLES Source Type: research

The need for pulmonary rehabilitation following tuberculosis treatment
(Source: International Journal of Tuberculosis and Lung Disease)
Source: International Journal of Tuberculosis and Lung Disease - July 29, 2020 Category: Respiratory Medicine Authors: Visca, D. Centis, R. D ' Ambrosio, L. Mu ñoz-Torrico, M. Chakaya, J. Muhwa Tiberi, S. Spanevello, A. Sotgiu, G. Migliori, G. B. Tags: LETTERS Source Type: research

Patterns of suboptimal adherence among adolescents treated for tuberculosis
(Source: International Journal of Tuberculosis and Lung Disease)
Source: International Journal of Tuberculosis and Lung Disease - July 29, 2020 Category: Respiratory Medicine Authors: Chiang, S. S. Beckhorn, C. B. Wong, M. Lecca, L. Franke, M. F. Tags: LETTERS Source Type: research

Effects of COPD guideline training on physicians' knowledge and awareness
(Source: International Journal of Tuberculosis and Lung Disease)
Source: International Journal of Tuberculosis and Lung Disease - July 29, 2020 Category: Respiratory Medicine Authors: Alsubaiei, M. E. Frith, P. A. Cafarella, P. A. Quinnd, S. Al Moamary, M. S. McEvoy, R. D. Effing, T. W. Tags: LETTERS Source Type: research

Subclinical tuberculosis and adverse infant outcomes in pregnant women with HIV
(Source: International Journal of Tuberculosis and Lung Disease)
Source: International Journal of Tuberculosis and Lung Disease - July 29, 2020 Category: Respiratory Medicine Authors: Rickman, H. M. Cohn, S. Lala, S. G. Waja, Z. Salazar-Austin, N. Hoffmann, J. Dooley, K. E. Hoffmann, C. J. Chaisson, R. E. Martinson, N. A. and the TSHEPISO Study Team Tags: ORIGINAL ARTICLES Source Type: research

Effect of Global Fund financial support for patients with multidrug-resistant tuberculosis
(Source: International Journal of Tuberculosis and Lung Disease)
Source: International Journal of Tuberculosis and Lung Disease - July 29, 2020 Category: Respiratory Medicine Authors: Watthananukul, T. Liabsuetrakul, T. Pungrassami, P. Chongsuvivatwong, V. Tags: ORIGINAL ARTICLES Source Type: research

CureTB and continuity of care for globally mobile patients
(Source: International Journal of Tuberculosis and Lung Disease)
Source: International Journal of Tuberculosis and Lung Disease - July 29, 2020 Category: Respiratory Medicine Authors: Figueroa, A. Vonnahme, L. Burrell, K. Vera-Garc ía, C. Gulati, R. K. Tags: ORIGINAL ARTICLES Source Type: research

Functional impact of sequelae in drug-susceptible and multidrug-resistant tuberculosis
(Source: International Journal of Tuberculosis and Lung Disease)
Source: International Journal of Tuberculosis and Lung Disease - July 29, 2020 Category: Respiratory Medicine Authors: Mu ñoz-Torrico, M. Cid-Ju árez, S. Gochicoa-Rangel, L. Torre-Bouscolet, L. Salazar-Lezama, M. A. Villarreal-Velarde, H. P érez-Padilla, R. Visca, D. Centis, R. D ' Ambrosio, L. Spanevello, A. Saderi, L. Sotgiu, G. Migliori, G. B. Tags: ORIGINAL ARTICLES Source Type: research

Use of insurance claims and electronic health records to assess tuberculosis and latent tuberculosis diagnosis
(Source: International Journal of Tuberculosis and Lung Disease)
Source: International Journal of Tuberculosis and Lung Disease - July 29, 2020 Category: Respiratory Medicine Authors: Rossato Silva, D. van den Hof, S. Tags: EDITORIALS Source Type: research

What will it take to achieve meaningful action on tuberculosis among Indigenous Peoples?
(Source: International Journal of Tuberculosis and Lung Disease)
Source: International Journal of Tuberculosis and Lung Disease - July 29, 2020 Category: Respiratory Medicine Authors: Basham, C. A. Grewal, N. Orr, P. H. McMullin, K. Wobeser, W. Tags: EDITORIALS Source Type: research

Automated chest radiography and mass systematic screening for tuberculosis
(Source: International Journal of Tuberculosis and Lung Disease)
Source: International Journal of Tuberculosis and Lung Disease - July 29, 2020 Category: Respiratory Medicine Authors: Madhani, F. Maniar, R. A. Burfat, A. Ahmed, M. Farooq, S. Sabir, A. Domki, A. K. Page-Shipp, L. Khowaja, S. Safdar, N. Khan, A. J. Khan, P. Y. Tags: ORIGINAL ARTICLES Source Type: research

Density of tobacco advertising around schools
(Source: International Journal of Tuberculosis and Lung Disease)
Source: International Journal of Tuberculosis and Lung Disease - July 29, 2020 Category: Respiratory Medicine Authors: Nurjanah, N. Manglapy, Y. M. Handayani, S. Ahsan, A. Sutomo, R. Dewi, F. S. T. Chang, P. Kusuma, D. Tags: ORIGINAL ARTICLES Source Type: research

Transient Pleural Fluid Infiltration by Clonal Plasma Cells Associated with Pulmonary Tuberculosis
Pleural effusion is a rare presentation of plasma cell myeloma, occurring in around 6% of patients during the course of their disease, most commonly as a consequence of a concurrent disease process like heart failure secondary to amyloid deposition. Direct infiltration of the pleural fluid by malignant cells leading to myelomatous pleural effusion is a rare mechanism occurring in less than 1% of patients with plasma cell myeloma, and it is associated with a worse prognosis. There are few case reports of myelomatous pleural effusion as an initial presentation of multiple myeloma. Pleural fluid infiltration by monoclonal pla...
Source: Case Reports in Oncology - July 29, 2020 Category: Cancer & Oncology Source Type: research

Latent Tuberculosis Screening Using Electronic Health Record Data
J. D. Jenks et al. (Source: Emerging Infectious Diseases Journal)
Source: Emerging Infectious Diseases Journal - July 29, 2020 Category: Infectious Diseases Source Type: research

Community health volunteers ’ contribution to tuberculosis patients notified to National Tuberculosis program through contact investigation in Kenya
Contact investigation is important in finding contacts of people who have Tuberculosis (TB) disease so that they can be given treatment and stop further transmission. The main objective of this study was to as... (Source: BMC Public Health)
Source: BMC Public Health - July 29, 2020 Category: Consumer Health News Authors: Tabitha Abongo, Benson Ulo and Sarah Karanja Tags: Research article Source Type: research

A synergistic bactericidal effect of low-frequency and low-intensity ultrasound combined with levofloxacin-loaded PLGA nanoparticles on M. smegmatis in macrophages
This study is performed to investigate the bactericidal effect and underlying mec... (Source: Journal of Nanobiotechnology)
Source: Journal of Nanobiotechnology - July 29, 2020 Category: Nanotechnology Authors: Shuang Xie, Gangjing Li, Yuru Hou, Min Yang, Fahui Li, Jianhu Li, Dairong Li and Yonghong Du Tags: Research Source Type: research

Screening approach among newly arrived asylum seekers: experience in a primary health care setting in Piacenza, Emilia Romagna, Northern Italy
In the last ten years the number of asylum seekers has increased in all of Europe. Our Migrants Health Unit in Piacenza, Emilia Romagna, Italy, is designated to provide primary health care for migrants without a regular permit of stay and, since 2015, is the reference center for asylum-seekers in our Province. Aim of this study is to describe the results of the screening for infectious diseases performed in asylum seekers from January 2015 to December 2015. For any asylum seekers referred to our Centre, we recorded demographical data and we offered screening for HIV, HBV, HCV, syphilis and active tuberculosis (TB). Descrip...
Source: Journal of Preventive Medicine and Hygiene - July 29, 2020 Category: International Medicine & Public Health Authors: ALESSANDRA DONISI, LAURA GERNA, TOMMASO FIETTA, CECILIA GRECCHI Source Type: research

Treatment success, but living with the consequences of post-tuberculosis sequelae
(Source: International Journal of Tuberculosis and Lung Disease)
Source: International Journal of Tuberculosis and Lung Disease - July 28, 2020 Category: Respiratory Medicine Authors: Tadyanemhandu, C. Chirenda, J. Garvey, C. Metcalfe, J. Tags: EDITORIALS Source Type: research

The σ Subunit-Remodeling Factors: An Emerging Paradigms of Transcription Regulation
Transcription initiation is a key checkpoint and highly regulated step of gene expression. The sigma (σ) subunit of RNA polymerase (RNAP) controls all transcription initiation steps, from recognition of the −10/−35 promoter elements, upon formation of the closed promoter complex (RPc), to stabilization of the open promoter complex (RPo) and stimulation of the primary steps in RNA synthesis. The canonical mechanism to regulate σ activity upon transcription initiation relies on activators that recognize specific DNA motifs and recruit RNAP to promoters. This mini-review describes an emerging group of ...
Source: Frontiers in Microbiology - July 28, 2020 Category: Microbiology Source Type: research

Using Droplet Digital PCR in the Detection of Mycobacterium tuberculosis DNA in FFPE Samples
(Source: International Journal of Infectious Diseases)
Source: International Journal of Infectious Diseases - July 28, 2020 Category: Infectious Diseases Authors: Ziyang Cao, Wei Wu, Haiting Wei, Caixia Gao, Liping Zhang, Chunyan Wu, Likun Hou Source Type: research

Molecular characteristics and in vitro susceptibility to bedaquiline of Mycobacterium tuberculosis isolates circulating in Shaanxi, China
Tuberculosis (TB) is an infectious disease that has threatened the heath of human being in the word today (World Health Oragnization, 2019). The emergence of multidrug-resistant tuberculosis (MDR-TB), particularly for extensively drug-resistant tuberculosis (XDR-TB) poses a major challenge to global TB control. At present, the treatment regimens for drug-resistant TB are longer, more expensive and less effective than that of drug-susceptible TB. The treatment for MDR-TB and XDR-TB has often failed due to lack of effective drugs, it's an urgent need to develop new anti tuberculosis drugs with high efficiency and short treat...
Source: International Journal of Infectious Diseases - July 28, 2020 Category: Infectious Diseases Authors: Jian Yang, Yu Pang, Tianhua Zhang, Xiaoping Xian, Yan Li, Rui Wang, Panting Wang, Zhang Meng, Junyang Wang Source Type: research

Redox Imbalance and Oxidative DNA Damage During Isoniazid Treatment of HIV-Associated Tuberculosis: A Clinical and Translational Pharmacokinetic Study
ConclusionsIsoniazid and its metabolites share the potential for oxidative cellular damage, with the greatest effects observed for hydrazine. Future studies should investigate the clinical consequences of oxidative stress with regards to clinical episodes of drug induced liver injury during isoniazid treatment. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - July 28, 2020 Category: Drugs & Pharmacology Source Type: research

New insights into the evasion of host innate immunity by Mycobacterium tuberculosis.
Abstract Mycobacterium tuberculosis (Mtb) is an extremely successful intracellular pathogen that causes tuberculosis (TB), which remains the leading infectious cause of human death. The early interactions between Mtb and the host innate immune system largely determine the establishment of TB infection and disease development. Upon infection, host cells detect Mtb through a set of innate immune receptors and launch a range of cellular innate immune events. However, these innate defense mechanisms are extensively modulated by Mtb to avoid host immune clearance. In this review, we describe the emerging role of cytoso...
Source: Cellular and Molecular Immunology - July 28, 2020 Category: Molecular Biology Authors: Chai Q, Wang L, Liu CH, Ge B Tags: Cell Mol Immunol Source Type: research

Pentacyanoferrate(II) complex of pyridine-4- and pyrazine-2-hydroxamic acid as source of HNO: investigation of anti-tubercular and vasodilation activities.
son V Abstract A pharmacophore design approach, based on the coordination chemistry of an intimate molecular hybrid of active metabolites of pro-drugs, known to release active species upon enzymatic oxidative activation, is devised. This is exemplified by combining two anti-mycobacterial drugs: pyrazinamide (first line) and delamanid (third line) whose active metabolites are pyrazinoic acid (PyzCOOH) and likely nitroxyl (HNO (or NO.)), respectively. Aiming to generate those active species, a hybrid compound was envisaged by coordination of pyrazine-2-hydroxamic acid (PyzCONHOH) with a Na3[FeII(CN)5] moie...
Source: Journal of Biological Inorganic Chemistry : JBIC - July 28, 2020 Category: Chemistry Authors: Carvalho EM, de Freitas Paulo T, Saquet AS, Abbadi BL, Macchi FS, Bizarro CV, de Morais Campos R, Ferreira TLA, do Nascimento NRF, Lopes LGF, Chauvin R, Sousa EHS, Bernardes-Génisson V Tags: J Biol Inorg Chem Source Type: research

Rapid, direct detection of bacterial Topoisomerase 1-DNA adducts by RADAR/ELISA.
Abstract Topoisomerases are proven drug targets, but antibiotics that poison bacterial Topoisomerase 1 (Top1) have yet to be discovered. We have developed a rapid and direct assay for quantification of Top1-DNA adducts that is suitable for high throughput assays. Adducts are recovered by "RADAR fractionation", a quick, convenient approach in which cells are lysed in chaotropic salts and detergent and nucleic acids and covalently bound adducts then precipitated with alcohol. Here we show that RADAR fractionation followed by ELISA immunodetection can quantify adducts formed by wild-type and mutant Top1 der...
Source: Analytical Biochemistry - July 28, 2020 Category: Biochemistry Authors: Sinha D, Kiianitsa K, Sherman DR, Maizels N Tags: Anal Biochem Source Type: research

A Novel In Vitro Mouse Model to Study Mycobacterium tuberculosis Dissemination Across Brain Vessels: A Combination Granuloma and Blood-Brain Barrier Mouse Model.
We present an in vitro mouse model of the BBB to test Mycobacterium tuberculosis (Mtb) dissemination across brain endothelial cells. One-third of the global population is infected with Mtb, and in 1%-2% of cases bacteria invade the CNS through a largely unknown process. The "Trojan horse" theory supports the role of a cellular carrier that engulfs bacteria and carries them to the brain without being recognized. We present for the first time a protocol for an in vitro BBB-granuloma model that supports the Trojan horse mechanism of Mtb dissemination into the CNS. Handling of bacterial cultures, in vivo and in vitro...
Source: Current Protocols in Immunology - July 28, 2020 Category: Allergy & Immunology Tags: Curr Protoc Immunol Source Type: research

Drug-resistant spinal tuberculosis – Current concepts, challenges, and controversies
Publication date: Available online 28 July 2020Source: Journal of Clinical Orthopaedics and TraumaAuthor(s): Dilip Chand Raja Soundararajan, Raja Bhaskara Rajasekaran, Shanmuganathan Rajasekaran, Ajoy Prasad Shetty, Rishi Mugesh Kanna (Source: Journal of Clinical Orthopaedics and Trauma)
Source: Journal of Clinical Orthopaedics and Trauma - July 28, 2020 Category: Orthopaedics Source Type: research

Exploring the usefulness of molecular epidemiology of tuberculosis in Africa: a systematic review.
CONCLUSION: TB molecular epidemiology tools have substantially improved our understanding of the MTBC circulating isolates, their evolution, and diversity in this highly endemic region of Africa. We found that only TB lineage 4 is present throughout all the continent and the clusters identified provides an extended insight into the disease transmission dynamics. PMID: 32714498 [PubMed] (Source: International Journal of Molecular Epidemiology and Genetics)
Source: International Journal of Molecular Epidemiology and Genetics - July 28, 2020 Category: Genetics & Stem Cells Tags: Int J Mol Epidemiol Genet Source Type: research

The prevention and control of tuberculosis: an analysis based on a tuberculosis dynamic model derived from the cases of Americans
Tuberculosis (TB), a preventable and curable disease, is claimed as the second largest number of fatalities, and there are 9,025 cases reported in the United States in 2018. Many researchers have done a lot of... (Source: BMC Public Health)
Source: BMC Public Health - July 28, 2020 Category: Consumer Health News Authors: Yan Wu, Meng Huang, Ximei Wang, Yong Li, Lei Jiang and Yuan Yuan Tags: Research article Source Type: research

Tuberculous Adenitis with Concurrent Hodgkin Lymphoma: A Case Report.
We reported such a case in a 15-year-old girl who presented with fever and neck swelling and was found to have lymphadenopathy. A biopsy of the right supraclavicular lymph node showed Reed-Sternberg cells and stained positive for acid-fast bacilli and tuberculosis culture. The patient was diagnosed with tuberculous adenitis with concurrent Hodgkin lymphoma in the same lymph node. She was started on anti-tubercular medications and chemotherapy and showed clinical improvement. This case highlights the need for suspicion in order to identify these two disorders in the same patient, since missing one of them is possible and ma...
Source: Oman Medical Journal - July 27, 2020 Category: Middle East Health Tags: Oman Med J Source Type: research

sncRNA-1 Is a Small Noncoding RNA Produced by Mycobacterium tuberculosis in Infected Cells That Positively Regulates Genes Coupled to Oleic Acid Biosynthesis
Nearly one third of the world’s population is infected with Mycobacterium tuberculosis (Mtb). While much work has focused on the role of different Mtb encoded proteins in pathogenesis, recent studies have revealed that Mtb also transcribes many noncoding RNAs whose functions remain poorly characterized. We performed RNA sequencing and identified a subset of Mtb H37Rv-encoded small RNAs (
Source: Frontiers in Microbiology - July 27, 2020 Category: Microbiology Source Type: research