Optimal dosing & time: Issues to get hydroxychloroquine safety & efficacy against COVID-19/SARS-CoV-2.
Optimal dosing & time: Issues to get hydroxychloroquine safety & efficacy against COVID-19/SARS-CoV-2. Indian J Med Res. 2020 Aug 13;: Authors: Neves FS PMID: 32801224 [PubMed - as supplied by publisher] (Source: The Indian Journal of Medical Research)
Source: The Indian Journal of Medical Research - August 13, 2020 Category: Biomedical Science Authors: Neves FS Tags: Indian J Med Res Source Type: research

Authors' response.
T, Singh KJ, Rasaily R, Singh R, Das S, Singh H, Praharaj I, Gangakhedkar RR, Bhargava B, Panda S PMID: 32801225 [PubMed - as supplied by publisher] (Source: The Indian Journal of Medical Research)
Source: The Indian Journal of Medical Research - August 13, 2020 Category: Biomedical Science Authors: Authors' response. Tags: Indian J Med Res Source Type: research

A critical appraisal of a case-control study on healthcare workers.
PMID: 32801226 [PubMed - as supplied by publisher] (Source: The Indian Journal of Medical Research)
Source: The Indian Journal of Medical Research - August 13, 2020 Category: Biomedical Science Authors: Mohanty T, Doke PP Tags: Indian J Med Res Source Type: research

Authors' response.
T, Singh KJ, Rasaily R, Singh R, Das S, Singh H, Praharaj I, Gangakhedkar RR, Bhargava B, Panda S PMID: 32801227 [PubMed - as supplied by publisher] (Source: The Indian Journal of Medical Research)
Source: The Indian Journal of Medical Research - August 13, 2020 Category: Biomedical Science Authors: Authors' response. Tags: Indian J Med Res Source Type: research

Lessons learnt during the first 100 days of COVID-19 pandemic in India.
PMID: 32611909 [PubMed - in process] (Source: The Indian Journal of Medical Research)
Source: The Indian Journal of Medical Research - May 1, 2020 Category: Biomedical Science Authors: Bhatia R, Abraham P Tags: Indian J Med Res Source Type: research

Impact of COVID-19 pandemic on health system & Sustainable Development Goal 3.
Impact of COVID-19 pandemic on health system & Sustainable Development Goal 3. Indian J Med Res. 2020 May;151(5):395-399 Authors: Khetrapal S, Bhatia R PMID: 32611910 [PubMed - in process] (Source: The Indian Journal of Medical Research)
Source: The Indian Journal of Medical Research - May 1, 2020 Category: Biomedical Science Authors: Khetrapal S, Bhatia R Tags: Indian J Med Res Source Type: research

Clinical management of COVID-19.
This article was aimed to review the evidence on clinical management and to deal with the identification of high-risk groups, warning signs, appropriate investigations, proper sample collection for confirmation, general and specific treatment measures, strategies as well as infection control in the healthcare settings. Advanced age, cardiovascular disease, diabetes, hypertension and cancer have been found to be the risk factors for severe disease. Fever lasting for>five days with tachypnoea, tachycardia or hypotension are indications for urgent attention and hospitalization in a patient with suspected COVID-19. At prese...
Source: The Indian Journal of Medical Research - May 1, 2020 Category: Biomedical Science Authors: Varghese GM, John R, Manesh A, Karthik R, Abraham OC Tags: Indian J Med Res Source Type: research

COVID-19 pandemic from an ophthalmology point of view.
Abstract Coronavirus disease 2019 (COVID-19) is caused by a highly contagious RNA virus termed as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Ophthalmologists are at high-risk due to their proximity and short working distance at the time of slit-lamp examination. Eye care professionals can be caught unaware because conjunctivitis may be one of the first signs of COVID-19 at presentation, even precluding the emergence of additional symptoms such as dry cough and anosmia. Breath and eye shields as well as N95 masks, should be worn while examining patients with fever, breathlessness, or any history ...
Source: The Indian Journal of Medical Research - May 1, 2020 Category: Biomedical Science Authors: Gupta PC, Kumar MP, Ram J Tags: Indian J Med Res Source Type: research

National sero-surveillance to monitor the trend of SARS-CoV-2 infection transmission in India: Protocol for community-based surveillance.
Abstract Conducting population-based serosurveillance for severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) will estimate and monitor the trend of infection in the adult general population, determine the socio-demographic risk factors and delineate the geographical spread of the infection. For this purpose, a serial cross-sectional survey would be conducted with a sample size of 24,000 distributed equally across four strata of districts categorized on the basis of the incidence of reported cases of COVID-19. Sixty districts will be included in the survey. Simultaneously, the survey will be done in 10 hi...
Source: The Indian Journal of Medical Research - May 1, 2020 Category: Biomedical Science Authors: Kumar MS, Bhatnagar T, Manickam P, Kumar VS, Rade K, Shah N, Kant S, Babu GR, Zodpey S, Girish Kumar CP, Vivian Thangaraj JW, Chatterjee P, Kanungo S, Pandey RM, Murhekar M, Singh SK, Sarkar S, Muliyi JP, Gangakhedkar RR, Reddy DCS Tags: Indian J Med Res Source Type: research

Laboratory surveillance for SARS-CoV-2 in India: Performance of testing & descriptive epidemiology of detected COVID-19, January 22 - April 30, 2020.
In this study, an analysis of the surveillance data was done to describe the testing performance and descriptive epidemiology of COVID-19 cases by time, place and person. Methods: The data were extracted from January 22 to April 30, 2020. The frequencies of testing performance were described over time and by place. We described cases by time (epidemic curve by date of specimen collection; seven-day moving average), place (area map) and person (attack rate by age, sex and contact status), and trends were represented along with public health measures and events. Results: Between January 22 and April 30, 2020, a tot...
Source: The Indian Journal of Medical Research - May 1, 2020 Category: Biomedical Science Authors: ICMR COVID Study Group (In alphabetical order: Priya Abraham†, Neeraj Aggarwa l2, Giridhara R. Babu 7, Suganya Barani 8, Balram Bhargava 4, Tarun Bhatnagar 8, Ajay Singh Dhama 3, Raman R. Gangakhedkar 2, Sidhartha Giri 2, Nivedita Gupta 2, Karishma K. K Tags: Indian J Med Res Source Type: research

Development of indigenous IgG ELISA for the detection of anti-SARS-CoV-2 IgG.
braham P, Gangakhedkar RR, $COVID Support Team: Pawar S., Patshute S., Salve V., Natarajan V., Marwah V., Malhotra B., Jain A., Sathe P., More R., Khedekar R., Suryawanshi D., Kalele K., Kumar A., Upadhyaya C.P., Waghmare A., Gawande P., Gopale S., Acharya M., Holeppanavar M., Thorat S., Chopade G., Vidhate S., Khutwad K., Phagiwala D., Bhanarkar S., Rakhe A., Salvi V., Dhaigude S., Ciyona Abstract Background & objectives: Since the beginning of the year 2020, the pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) impacted humankind adversely in almost all spheres of life. The viru...
Source: The Indian Journal of Medical Research - May 1, 2020 Category: Biomedical Science Authors: Sapkal G, Shete-Aich A, Jain R, Yadav PD, Sarkale P, Lakra R, Baradkar S, Deshpande GR, Mali D, Tilekar BN, Majumdar T, Kaushal H, Gurav Y, Gupta N, Mohandas S, Deshpande K, Kaduskar O, Salve M, Patil S, Gaikwad S, Sugunan AP, Ashok M, Giri S, Shastri J, Tags: Indian J Med Res Source Type: research

Healthcare workers & SARS-CoV-2 infection in India: A case-control investigation in the time of COVID-19.
Healthcare workers & SARS-CoV-2 infection in India: A case-control investigation in the time of COVID-19. Indian J Med Res. 2020 May;151(5):459-467 Authors: Chatterjee P, Anand T, Singh KJ, Rasaily R, Singh R, Das S, Singh H, Praharaj I, Gangakhedkar RR, Bhargava B, Panda S Abstract Background & objectives: Healthcare workers (HCWs) are at an elevated risk of contracting COVID-19. While intense occupational exposure associated with aerosol-generating procedures underlines the necessity of using personal protective equipment (PPE) by HCWs, high-transmission efficiency of the causative agent [se...
Source: The Indian Journal of Medical Research - May 1, 2020 Category: Biomedical Science Authors: Chatterjee P, Anand T, Singh KJ, Rasaily R, Singh R, Das S, Singh H, Praharaj I, Gangakhedkar RR, Bhargava B, Panda S Tags: Indian J Med Res Source Type: research

Evaluation of the susceptibility of mice & hamsters to SARS-CoV-2 infection.
Evaluation of the susceptibility of mice & hamsters to SARS-CoV-2 infection. Indian J Med Res. 2020 May;151(5):479-482 Authors: Mohandas S, Jain R, Yadav PD, Shete-Aich A, Sarkale P, Kadam M, Kumar A, Deshpande G, Baradkar S, Patil S, Sapkal G, Mali D, Salve M, Patil D, Majumdar T, Suryawanshi A, Kaushal H, Lakra R, Dighe H, Gupta N, Abraham P, Gangakhedkar RR PMID: 32611917 [PubMed - in process] (Source: The Indian Journal of Medical Research)
Source: The Indian Journal of Medical Research - May 1, 2020 Category: Biomedical Science Authors: Mohandas S, Jain R, Yadav PD, Shete-Aich A, Sarkale P, Kadam M, Kumar A, Deshpande G, Baradkar S, Patil S, Sapkal G, Mali D, Salve M, Patil D, Majumdar T, Suryawanshi A, Kaushal H, Lakra R, Dighe H, Gupta N, Abraham P, Gangakhedkar RR Tags: Indian J Med Res Source Type: research

First confirmed case of COVID-19 infection in India: A case report.
PMID: 32611918 [PubMed - in process] (Source: The Indian Journal of Medical Research)
Source: The Indian Journal of Medical Research - May 1, 2020 Category: Biomedical Science Authors: Andrews MA, Areekal B, Rajesh KR, Krishnan J, Suryakala R, Krishnan B, Muraly CP, Santhosh PV Tags: Indian J Med Res Source Type: research

A confirmed case of COVID-19 among the first three from Kerala, India.
PMID: 32611919 [PubMed - in process] (Source: The Indian Journal of Medical Research)
Source: The Indian Journal of Medical Research - May 1, 2020 Category: Biomedical Science Authors: Vaman RS, Valamparampil MJ, Ramdas AV, Manoj AT, Varghese B, Joseph F Tags: Indian J Med Res Source Type: research

Pandemic SARS-CoV-2 laboratory preparedness in India: An opportunity beyond diagnostics.
PMID: 32611920 [PubMed - in process] (Source: The Indian Journal of Medical Research)
Source: The Indian Journal of Medical Research - May 1, 2020 Category: Biomedical Science Authors: Dwibedi B Tags: Indian J Med Res Source Type: research

Authors' response.
Praharaj I, Giri S, Sapkal G, Yadav P, Choudhary ML, Dar L, Sugunan AP, Kaur H, Munivenkatappa A, Shastri J, Kaveri K, Dutta S, Malhotra B, Jain A, Nagamani K, Shantala GB, Raut S, Vegad MM, Sharma A, Choudhary A, Brijwa M, Balakrishnan A, Manjunatha J, Pathak M, Srinivasan S, Banu H, Sharma H, Jain P, Sunita P, Ambica R, Fageria B, Patel D, Rajbongshi G, Vijay N, Narayan J, Aggarwal N, Nagar A, Gangakhedkar RR, Abraham P PMID: 32611921 [PubMed - in process] (Source: The Indian Journal of Medical Research)
Source: The Indian Journal of Medical Research - May 1, 2020 Category: Biomedical Science Authors: Authors' response. Tags: Indian J Med Res Source Type: research

Creation of a network of tropical medicine units to implement 'One Health'.
PMID: 32611922 [PubMed - in process] (Source: The Indian Journal of Medical Research)
Source: The Indian Journal of Medical Research - May 1, 2020 Category: Biomedical Science Authors: Raina SK Tags: Indian J Med Res Source Type: research

Author's response.
PMID: 32611923 [PubMed - in process] (Source: The Indian Journal of Medical Research)
Source: The Indian Journal of Medical Research - May 1, 2020 Category: Biomedical Science Authors: Bhatia R Tags: Indian J Med Res Source Type: research

Community engagement in times of COVID-19: Lessons from neo-Vaishnavite practices.
PMID: 32611924 [PubMed - in process] (Source: The Indian Journal of Medical Research)
Source: The Indian Journal of Medical Research - May 1, 2020 Category: Biomedical Science Authors: Saikia B, Tamuli RP, Sharma D Tags: Indian J Med Res Source Type: research

Author's response.
PMID: 32611925 [PubMed - in process] (Source: The Indian Journal of Medical Research)
Source: The Indian Journal of Medical Research - May 1, 2020 Category: Biomedical Science Authors: Bhatia R Tags: Indian J Med Res Source Type: research

Infectious disease isolation facility with advanced engineering design: Need of the hour.
PMID: 32611926 [PubMed - in process] (Source: The Indian Journal of Medical Research)
Source: The Indian Journal of Medical Research - May 1, 2020 Category: Biomedical Science Authors: Dwibedi B Tags: Indian J Med Res Source Type: research

Authors' response.
Chatterjee P, Sarkar S, Mourya D, Sahay RR, Bhatia R PMID: 32611927 [PubMed - in process] (Source: The Indian Journal of Medical Research)
Source: The Indian Journal of Medical Research - May 1, 2020 Category: Biomedical Science Authors: Authors' response. Tags: Indian J Med Res Source Type: research

Erratum: Guidance for building a dedicated health facility to contain the spread of the 2019 novel coronavirus outbreak.
Authors: Abstract [This corrects the article DOI: 10.4103/ijmr.IJMR_518_20]. PMID: 32611928 [PubMed - in process] (Source: The Indian Journal of Medical Research)
Source: The Indian Journal of Medical Research - May 1, 2020 Category: Biomedical Science Tags: Indian J Med Res Source Type: research

The future of autism: Global & local achievements & challenges.
The future of autism: Global & local achievements & challenges. Indian J Med Res. 2020 Apr;151(4):263-265 Authors: Lord C PMID: 32461386 [PubMed - in process] (Source: The Indian Journal of Medical Research)
Source: The Indian Journal of Medical Research - April 1, 2020 Category: Biomedical Science Authors: Lord C Tags: Indian J Med Res Source Type: research

Accelerating progress towards ending tuberculosis in India.
PMID: 32461387 [PubMed - in process] (Source: The Indian Journal of Medical Research)
Source: The Indian Journal of Medical Research - April 1, 2020 Category: Biomedical Science Authors: Sachdeva KS Tags: Indian J Med Res Source Type: research

Thinking globally about cancer research on World Cancer Day.
PMID: 32461388 [PubMed - in process] (Source: The Indian Journal of Medical Research)
Source: The Indian Journal of Medical Research - April 1, 2020 Category: Biomedical Science Authors: Gopal S, Sivaram S, Rajaraman P, Trimble EL Tags: Indian J Med Res Source Type: research

Desmin dysregulation in gall bladder cancer.
PMID: 32461389 [PubMed - in process] (Source: The Indian Journal of Medical Research)
Source: The Indian Journal of Medical Research - April 1, 2020 Category: Biomedical Science Authors: Mittal B Tags: Indian J Med Res Source Type: research

Attack on statistical significance: A balanced approach for medical research.
PMID: 32461390 [PubMed - in process] (Source: The Indian Journal of Medical Research)
Source: The Indian Journal of Medical Research - April 1, 2020 Category: Biomedical Science Authors: Indrayan A Tags: Indian J Med Res Source Type: research

A juggernaut of innate & adaptive immune cells in chronic hepatitis C.
A juggernaut of innate & adaptive immune cells in chronic hepatitis C. Indian J Med Res. 2020 Apr;151(4):279-286 Authors: Tomer S, Arora SK Abstract Hepatitis C virus (HCV) is a small positive-sense, single-stranded RNA virus, the causal organism for chronic hepatitis. Chronic hepatitis leads to inflammation of liver, causing cirrhosis, fibrosis and steatosis, which may ultimately lead to liver cancer in a few cases. Innate and adaptive immune responses play an important role in the pathogenesis of HCV infection, thus acting as an important component in deciding the fate of the disease. Numerous s...
Source: The Indian Journal of Medical Research - April 1, 2020 Category: Biomedical Science Authors: Tomer S, Arora SK Tags: Indian J Med Res Source Type: research

Community-acquired bacterial pneumonia in adults: An update.
Abstract Community-acquired pneumonia (CAP) is the prominent cause of mortality and morbidity with important clinical impact across the globe. India accounts for 23 per cent of global pneumonia burden with case fatality rates between 14 and 30 per cent, and Streptococcus pneumoniae is considered a major bacterial aetiology. Emerging pathogens like Burkholderia pseudomallei is increasingly recognized as an important cause of CAP in Southeast Asian countries. Initial management in the primary care depends on clinical assessment while the hospitalized patients require combinations of clinical scores, chest radiograph...
Source: The Indian Journal of Medical Research - April 1, 2020 Category: Biomedical Science Authors: Eshwara VK, Mukhopadhyay C, Rello J Tags: Indian J Med Res Source Type: research

ICMR Consensus Guidelines on 'Do Not Attempt Resuscitation'.
Abstract Cardiopulmonary resuscitation (CPR) is widely practised by healthcare professionals to revive heart beat and breathing in a patient suffering from cardiac/ respiratory arrest. It is increasingly being recognized that in some patients with specific medical conditions, CPR does not alter the overall outcome of illness, and is likely to increase suffering and further deteriorate the quality of life. Do Not Attempt Resuscitation (DNAR) as an option has been practised in many countries for such cases to avoid futile CPR and maintain dignity of the patient. The decision of DNAR should be taken by the treating p...
Source: The Indian Journal of Medical Research - April 1, 2020 Category: Biomedical Science Authors: Mathur R Tags: Indian J Med Res Source Type: research

Epigenetic downregulation of desmin in gall bladder cancer reveals its potential role in disease progression.
Abstract Background & objectives: Gall bladder cancer (GBC) is a fatal neoplasm, with a globally variable incidence rates. To improve the survival rate of patients, a newer set of biomarkers needs to be discovered for its early detection and better prognosis. Our earlier studies on GBC proteomics and whole-genome methylome data revealed expression of desmin to be significantly downregulated with correlated promoter hypermethylation during gall bladder carcinogenesis. Thus, to evaluate desmin as a potential biomarker for GBC, we carried out a detailed follow up study. Methods: Methylation-specific polymera...
Source: The Indian Journal of Medical Research - April 1, 2020 Category: Biomedical Science Authors: Bhunia S, Barbhuiya MA, Gupta S, Shrivastava BR, Tiwari PK Tags: Indian J Med Res Source Type: research

Club cell protein 16 as a biomarker for early detection of silicosis.
This study evaluated the suitability of club cell protein (CC16) as a biomarker for early detection of silicosis. Methods: This pilot study included 121 individuals from X-ray-confirmed/advanced silicosis, moderate silica dust-exposed workers and healthy controls from western India. CC16 levels were quantified in serum samples through ELISA. Sensitivity and specificity of CC16 values at different cut-off points were calculated in both non-smokers and smokers. Results: Serum CC16 level was significantly (P
Source: The Indian Journal of Medical Research - April 1, 2020 Category: Biomedical Science Authors: Naha N, Muhamed JCJ, Pagdhune A, Sarkar B, Sarkar K Tags: Indian J Med Res Source Type: research

Homozygous sickle cell disease in Central India & Jamaica: A comparison of newborn cohorts.
Homozygous sickle cell disease in Central India & Jamaica: A comparison of newborn cohorts. Indian J Med Res. 2020 Apr;151(4):326-332 Authors: Jain D, Tokalwar R, Upadhye D, Colah R, Serjeant GR Abstract Background & objectives: Homozygous sickle cell (SS) disease in Central India runs a more severe clinical course than reports from other areas of India. The current study was undertaken to compare the disease in Central India (Nagpur) with that in Jamaica, both populations defined by newborn screening. Methods: The Nagpur cohort included infants born to sickling-positive mothers from May ...
Source: The Indian Journal of Medical Research - April 1, 2020 Category: Biomedical Science Authors: Jain D, Tokalwar R, Upadhye D, Colah R, Serjeant GR Tags: Indian J Med Res Source Type: research

Fibroscan as a non-invasive predictor of hepatic steatosis in women with polycystic ovary syndrome.
The objective of this study was thus to investigate the frequency of hepatic steatosis in young women with PCOS and evaluate the utility of transient elastography (TE) in its assessment. Methods: Seventy women diagnosed with PCOS and 60 apparently healthy women (controls) were enrolled in this pilot study. These women were evaluated for clinical, biochemical and hormonal parameters, transabdominal ultrasonography, dual-energy X-ray absorptiometry and fibroscan assessing liver stiffness measure (LSM) and controlled attenuation parameter (CAP). Other indices such as liver fat score (LFS), lipid accumulation product (LAP...
Source: The Indian Journal of Medical Research - April 1, 2020 Category: Biomedical Science Authors: Chakraborty S, Ganie MA, Masoodi I, Jana M, Shalimar, Gupta N, Sofi NY Tags: Indian J Med Res Source Type: research

Serum procalcitonin as a biomarker of bloodstream infection & focal bacterial infection in febrile patients.
This study was conducted to measure the serum procalcitonin (PCT) levels at the time of initial presentation as a biomarker for identifying bacteraemia and as a predictor of mortality in patients admitted with acute fever. Methods: Four hundred and eighty patients, who presented with acute fever requiring admission to a tertiary care teaching hospital in south India, were prospectively studied. All patients were evaluated with a detailed history, physical examination, laboratory and imaging studies. Baseline serum PCT was measured for each patient within six hours of admission. Results: Among patients with single...
Source: The Indian Journal of Medical Research - April 1, 2020 Category: Biomedical Science Authors: Harikrishna J, Mohan A, Kalyana Chakravarthi DP, Chaudhury A, Kumar BS, Sarma KVS Tags: Indian J Med Res Source Type: research

Seroprevalence & seroincidence of Orientia tsutsugamushi infection in Gorakhpur, Uttar Pradesh, India: A community-based serosurvey during lean (April-May) & epidemic (October-November) periods for acute encephalitis syndrome.
Seroprevalence & seroincidence of Orientia tsutsugamushi infection in Gorakhpur, Uttar Pradesh, India: A community-based serosurvey during lean (April-May) & epidemic (October-November) periods for acute encephalitis syndrome. Indian J Med Res. 2020 Apr;151(4):350-360 Authors: Kamble S, Mane A, Sane S, Sonavale S, Vidhate P, Singh MK, Gangakhedkar R, Gupte M Abstract Background & objectives: In India, acute encephalitis syndrome (AES) cases are frequently reported from Gorakhpur district in Uttar Pradesh. Scrub typhus is one of the predominant aetiological agents for these cases. In order ...
Source: The Indian Journal of Medical Research - April 1, 2020 Category: Biomedical Science Authors: Kamble S, Mane A, Sane S, Sonavale S, Vidhate P, Singh MK, Gangakhedkar R, Gupte M Tags: Indian J Med Res Source Type: research

Genotype analysis of ofloxacin-resistant multidrug-resistant Mycobacterium tuberculosis isolates in a multicentered study from India.
This study was conducted to investigate the molecular characteristics of ofloxacin (OFX)-resistant, multidrug-resistant tuberculosis (MDR-TB) isolates from different geographical regions of India and their association with strains of different genotypes. Further, the nitrate reductase assay (NRA) was tested against Mycobacteria Growth Indicator Tube(MGIT) for the determination of OFX resistance as an alternative and cost-effective method. Methods: A total of 116 Mycobacterium tuberculosis isolates were used to assess the mutations in the gyrA, gyrB genes and resistance levels to OFX. Mutational analysis in gyrA and gy...
Source: The Indian Journal of Medical Research - April 1, 2020 Category: Biomedical Science Authors: Gupta A, Sinha P, Rathod S, Shanmugam SK, Uma Devi KR, Anupurba S, Nema V Tags: Indian J Med Res Source Type: research

Fractional iron absorption from enteric-coated ferrous sulphate tablet.
Abstract Background & objectives: Iron supplementation is widely used public health measure to manage iron deficiency anaemia. In India, enteric-coated iron tablets are administered to adolescent boys and girls to avoid adverse effects such as gastritis, which reduces compliance, but this may result in poor iron absorption. Data on the absorption of iron from enteric-coated ferrous sulphate tablets are lacking. The present study using stable isotopic approach was aimed to measure iron absorption in iron deficient women. Methods: Iron absorption was measured from stable isotope-labelled enteric-coated ferr...
Source: The Indian Journal of Medical Research - April 1, 2020 Category: Biomedical Science Authors: Thankachan P, Bose B, Subramanian R, Koneri R, Kurpad AV Tags: Indian J Med Res Source Type: research

Molecular characterization of hepatitis A virus circulating in Uttar Pradesh, India: A hospital-based study.
Abstract Background & objectives: Hepatitis A is prevalent worldwide and is among the leading cause of acute viral hepatitis in India. Major geographical differences in endemicity of hepatitis A are closely related to hygienic and sanitary conditions and other indicators of the level of socio-economic development. The present study was aimed to know the seropositivity prevalence and predominant circulating strain of HAV in a north India. Methods: Patients with acute viral hepatitis were enrolled. Blood samples were collected over a period of one year from June 2016 to May 2017. Serum samples were tested f...
Source: The Indian Journal of Medical Research - April 1, 2020 Category: Biomedical Science Authors: Prakash S, Shukla S, Shukla R, Bhagat A, Srivastava SS, Jain A Tags: Indian J Med Res Source Type: research

Limb gangrene: The first sign of essential thrombocythemia.
PMID: 32461403 [PubMed - in process] (Source: The Indian Journal of Medical Research)
Source: The Indian Journal of Medical Research - April 1, 2020 Category: Biomedical Science Authors: Bolaman AZ, Yavaşoǧlu İ Tags: Indian J Med Res Source Type: research

Ethics preparedness for infectious disease outbreaks research in India: A case for novel coronavirus disease 2019.
PMID: 32362641 [PubMed - in process] (Source: The Indian Journal of Medical Research)
Source: The Indian Journal of Medical Research - February 1, 2020 Category: Biomedical Science Authors: Mathur R Tags: Indian J Med Res Source Type: research

The 2019 novel coronavirus disease (COVID-19) pandemic: A review of the current evidence.
Abstract A novel coronavirus (nCoV) spillover event, with its epicenter in Wuhan, People's Republic of China, has emerged as a public health emergency of international concern. This began as an outbreak in December 2019, and till February 28, 2020, there have been 83,704 confirmed cases of novel coronavirus disease 2019 (COVID-19) globally, with 2,859 deaths, resulting in an overall case fatality rate of 3.41 per cent (95% confidence interval 3.29-3.54%). By this time (February 28, 2020) 58 countries or territories and one international conveyance (Diamond Princess Cruise Ship) were affected. As a part of the glob...
Source: The Indian Journal of Medical Research - February 1, 2020 Category: Biomedical Science Authors: Chatterjee P, Nagi N, Agarwal A, Das B, Banerjee S, Sarkar S, Gupta N, Gangakhedkar RR Tags: Indian J Med Res Source Type: research

Guidance for building a dedicated health facility to contain the spread of the 2019 novel coronavirus outbreak.
This article describes elements of design of such unit (e.g., space, infection control, waste disposal, safety of healthcare workers, partners to be involved in design and plan) which can be adapted to the context of either a new construction or makeshift construction on top of an existing structure. In view of a potential epidemic of COVID-19, specific requirements to handle it are also given. PMID: 32362643 [PubMed - in process] (Source: The Indian Journal of Medical Research)
Source: The Indian Journal of Medical Research - February 1, 2020 Category: Biomedical Science Authors: Agarwal A, Nagi N, Chatterjee P, Sarkar S, Mourya D, Sahay RR, Bhatia R Tags: Indian J Med Res Source Type: research

Lopinavir/ritonavir combination therapy amongst symptomatic coronavirus disease 2019 patients in India: Protocol for restricted public health emergency use.
Abstract As of February 29, 2020, more than 85,000 cases of coronavirus disease 2019 (COVID-19) have been reported from China and 53 other countries with 2,924 deaths. On January 30, 2020, the first laboratory-confirmed case of COVID was reported from Kerala, India. In view of the earlier evidence about effectiveness of repurposed lopinavir/ritonavir against severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS) coronavirus (CoV), as well as preliminary docking studies conducted by the ICMR-National Institute of Virology, Pune, the Central Drugs Standard Control Organization approved ...
Source: The Indian Journal of Medical Research - February 1, 2020 Category: Biomedical Science Authors: Bhatnagar T, Murhekar MV, Soneja M, Gupta N, Giri S, Wig N, Gangakhedkar R Tags: Indian J Med Res Source Type: research

Prudent public health intervention strategies to control the coronavirus disease 2019 transmission in India: A mathematical model-based approach.
The objectives of this study were to find out if it was possible to prevent, or delay, the local outbreaks of COVID-19 through restrictions on travel from abroad and if the virus has already established in-country transmission, to what extent would its impact be mitigated through quarantine of symptomatic patients? Methods: These questions were addressed in the context of India, using simple mathematical models of infectious disease transmission. While there remained important uncertainties in the natural history of COVID-19, using hypothetical epidemic curves, some key findings were illustrated that appeared insensit...
Source: The Indian Journal of Medical Research - February 1, 2020 Category: Biomedical Science Authors: Mandal S, Bhatnagar T, Arinaminpathy N, Agarwal A, Chowdhury A, Murhekar M, Gangakhedkar RR, Sarkar S Tags: Indian J Med Res Source Type: research

Strategic planning to augment the testing capacity for COVID-19 in India.
The objective of this exercise was to prepare a potential plan to scale-up COVID-19 testing in India in the public sector. Methods: Potential increase in daily testing capacity of the existing public laboratories was calculated across the three base scenarios of shifts (9, 16 and 24 h). Additional testing capacity was added for each shift scenario based on interventions ranging from procurement of additional qRT-PCR machines, leveraging spare capacity on available qRT-PCR machines not drafted into COVID-19 testing, to in-laboratory process optimization efforts. Results: Moving to a 24 h working model in the exist...
Source: The Indian Journal of Medical Research - February 1, 2020 Category: Biomedical Science Authors: Gupta N, Bhatnagar T, Rade K, Murhekar M, Gangakhedkar RR, Nagar A, ICMR COVID Team Tags: Indian J Med Res Source Type: research

Severe acute respiratory illness surveillance for coronavirus disease 2019, India, 2020.
We describe here the positivity for COVID-19 among SARI patients and their characteristics. Methods: SARI patients admitted at 41 sentinel sites from February 15, 2020 onwards were tested for COVID-19 by real-time reverse transcription-polymerase chain reaction, targeting E and RdRp genes of SARS-CoV-2. Data were extracted from Virus Research and Diagnostic Laboratory Network for analysis. Results: A total of 104 (1.8%) of the 5,911 SARI patients tested were positive for COVID-19. These cases were reported from 52 districts in 20 States/Union Territories. The COVID-19 positivity was higher among males and patient...
Source: The Indian Journal of Medical Research - February 1, 2020 Category: Biomedical Science Authors: Gupta N, Praharaj I, Bhatnagar T, Vivian Thangaraj JW, Giri S, Chauhan H, Kulkarni S, Murhekar M, Singh S, Gangakhedkar RR, Bhargava B, ICMR COVID Team Tags: Indian J Med Res Source Type: research

Transmission electron microscopy imaging of SARS-CoV-2.
PMID: 32362648 [PubMed - in process] (Source: The Indian Journal of Medical Research)
Source: The Indian Journal of Medical Research - February 1, 2020 Category: Biomedical Science Authors: Prasad S, Potdar V, Cherian S, Abraham P, Basu A, ICMR-NIV NIC Team Tags: Indian J Med Res Source Type: research