Patient safety & universal health coverage in India.
Patient safety & universal health coverage in India. Indian J Med Res. 2019 Sep;150(3):211-213 Authors: Lahariya C, Agarwal L, de Graeve H, Bekedam H PMID: 31719289 [PubMed - in process] (Source: Indian J Med Res)
Source: Indian J Med Res - September 1, 2019 Category: Research Authors: Lahariya C, Agarwal L, de Graeve H, Bekedam H Tags: Indian J Med Res Source Type: research

Ki-67, an elusive marker in the prognosis of breast cancer.
PMID: 31719290 [PubMed - in process] (Source: Indian J Med Res)
Source: Indian J Med Res - September 1, 2019 Category: Research Authors: Sood N Tags: Indian J Med Res Source Type: research

Influenza pandemic preparedness: A special challenge for India.
PMID: 31719291 [PubMed - in process] (Source: Indian J Med Res)
Source: Indian J Med Res - September 1, 2019 Category: Research Authors: Fedson DS Tags: Indian J Med Res Source Type: research

Anti-thymocyte globulin in haematology: Recent developments.
Abstract Anti-thymocyte globulin (ATG) is a polyclonal antiserum introduced into clinical medicine more than 30 years ago. It induces a broad non-specific immunosuppression. In haematology, standard indications are severe aplastic anaemia and prophylaxis and treatment of graft-versus-host disease (GVHD) (after allogeneic transplantation). For aplastic anaemia, ATG from horses has been found to be superior to ATG from rabbits. In the situation of allogeneic transplantation, ATG lessens the risk of chronic GVHD but may not improve survival. There is current controversy regarding which patients benefit most from ATG ...
Source: Indian J Med Res - September 1, 2019 Category: Research Authors: Siddiqui S, Cox J, Herzig R, Palaniyandi S, Hildebrandt GC, Munker R Tags: Indian J Med Res Source Type: research

Illicit drugs: Effects on eye.
This article describes in brief some of the ocular effects of commonly abused drugs. For identification of a particular poisoning, in addition to the clinical presentation, pulse, blood pressure, respiration and body temperature, pupillary size, pupillary reaction to light, ocular convergence and nystagmus can be useful indicators of the type of drug the patient is exposed to. Unmasking these features help the clinician in an early and accurate diagnosis of the offending drug as well as timely management. PMID: 31719293 [PubMed - in process] (Source: Indian J Med Res)
Source: Indian J Med Res - September 1, 2019 Category: Research Authors: Dhingra D, Kaur S, Ram J Tags: Indian J Med Res Source Type: research

National Iron Plus Initiative: Current status & future strategy.
National Iron Plus Initiative: Current status & future strategy. Indian J Med Res. 2019 Sep;150(3):239-247 Authors: Kapil U, Kapil R, Gupta A Abstract Anaemia is a severe public health problem amongst all vulnerable age groups in India. The National Nutritional Anaemia Prophylaxis Programme initiated in 1970, was revised and expanded to include beneficiaries from all age groups namely children aged 6-59 months, 5-10 yr, adolescents aged 10-19 yr, pregnant and lactating women and women in reproductive age group under the National Iron Plus Initiative (NIPI) programme in 2011. The dose of iron, freq...
Source: Indian J Med Res - September 1, 2019 Category: Research Authors: Kapil U, Kapil R, Gupta A Tags: Indian J Med Res Source Type: research

The grand challenge of regulating health foods in India.
Abstract Food is the primary source of nutrients to keep us nourished and healthy. Poor and unhealthy diets implicated with the increase of several non-communicable diseases (NCDs) require a food-based approach to reduce the ongoing rise. Traditional knowledge and science behind food-related health benefits became evident in the last three decades. Active ingredients, bioactive molecules and conventionally used herbs were clinically researched and proven to have beneficial outcomes. In the Indian scenario, the multiplicity of food products, including medicinal type formats, such as health supplements, containing p...
Source: Indian J Med Res - September 1, 2019 Category: Research Authors: Boindala S, Lewis JI Tags: Indian J Med Res Source Type: research

Diagnostic ability of real-time quantitative polymerase chain reaction versus immunohistochemistry for Ki-67 assessment in breast cancer: An Indian perspective.
This study was aimed at defining the analytical and clinical validity of real-time quantitative polymerase chain reaction (RT-qPCR) as an alternative to IHC evaluation. Methods: This study included a total of 109 patients with invasive breast cancers. Ki-67 IHC visual assessment was compared with the mRNA value determined by RT-qPCR. Concordance between both the methods was assessed. Receiver operating characteristic (ROC) curve analysis and Cohen's kappa value with intraclass correlation were performed. Results: The threshold value for Ki-67 by RT-qPCR obtained by ROC curve was 22.23 per cent, which was used to ...
Source: Indian J Med Res - September 1, 2019 Category: Research Authors: Mehta A, Kumar D, Chadha P, Goswami M, Vishwakarma G, Panigrahi M, Suryavanshi M, Panaych A Tags: Indian J Med Res Source Type: research

Pharmacogenetic analyses of variations of measures of cardiovascular risk in Alzheimer's dementia.
This study was aimed to estimate variations of measures of cardiovascular risk in Alzheimer's dementia by pharmacogenetic analyses of the effects of angiotensin-converting enzyme (ACE) inhibitors and statins. Methods: Consecutive patients were prospectively followed to study variations of creatinine clearance and blood pressure for one year, estimated by correlating the effects of ACE inhibitors with the ACE Alu I/D polymorphism and genotypes or haplotypes of rs1800764 or rs4291, and the effects of statins with LDLR (low-density lipoprotein receptor) genotypes or haplotypes of rs11669576 (exon 8) or rs5930 (exon 10), ...
Source: Indian J Med Res - September 1, 2019 Category: Research Authors: de Oliveira FF, Berretta JM, de Almeida Junior GV, de Almeida SS, Chen ES, Smith MC, Bertolucci PHF Tags: Indian J Med Res Source Type: research

Haplotype analysis of ADAM33 polymorphisms in asthma: A pilot study.
Abstract Background & objectives: ADAM33 is implicated as a potentially strong candidate gene for asthma and bronchial hyper-responsiveness. Many polymorphisms of ADAM33 have been studied along with ADAM33 expression in various cells of the lungs. Haplotype analysis also showed association with asthma in different populations across the world. Therefore, the aim of this study was to perform a comprehensive screening of ADAM33 polymorphisms in adult patients with asthma. Methods: Thirty five polymorphisms of ADAM33 were genotyped in 55 patients with asthma and 53 controls. The association of single nucleot...
Source: Indian J Med Res - September 1, 2019 Category: Research Authors: Vishweswaraiah S, Ramachandra NB, Jayaraj BS, Holla AD, Chakraborty S, Agrawal A, Mahesh PA Tags: Indian J Med Res Source Type: research

Targeted sequencing of the DMD locus: A comprehensive diagnostic tool for all mutations.
This study was planned to evaluate the targeted next-generation sequencing (NGS) as a single platform to detect all types of mutations in the DMD gene, thereby reducing the time and costs compared to conventional sequential testing and also provide precise genetic information for emerging gene therapies. Methods: The study included 20 unrelated families and 22 patients from an Indian population who were screened for DMD based on phenotypes such as scoliosis, toe walking and loss of ambulation. Peripheral blood DNA was isolated and subjected to multiplex ligation-dependent probe amplification (MLPA) and targeted NGS of...
Source: Indian J Med Res - September 1, 2019 Category: Research Authors: Aravind S, Ashley B, Mannan A, Ganapathy A, Ramesh K, Ramachandran A, Nongthomba U, Shastry A Tags: Indian J Med Res Source Type: research

DNA damage induced by exposure to pesticides in children of rural areas in Paraguay.
The objective of this study was to determine the frequency of DNA damage through the comet assay and micronucleus (MN) test in two groups of children, under 10 yr of age living in rural Paraguay and in relation to pesticide exposure. Methods: Two groups of 5 to 10 yr old children were formed; the exposed group (group A, n=43), born and currently living in a community dedicated to family agriculture and surrounded by transgenic soybean crops, and the control group (group B, n=41), born and living in a community dedicated to family agriculture with biological control of pests. For each child, 2000 cells were studied for...
Source: Indian J Med Res - September 1, 2019 Category: Research Authors: Leite SB, Franco de Diana DM, Segovia Abreu JA, Avalos DS, Denis MA, Ovelar CC, Samaniego Royg MJ, Thielmann Arbo BA, Corvalan R Tags: Indian J Med Res Source Type: research

Development & cross-validation of anthropometric predictive models to estimate the appendicular skeletal muscle mass in middle-aged women in Sri Lanka.
This study was designed to develop and cross-validate simple predictive models to estimate the ASMM based on anthropometry in a group of healthy middle-aged women in Sri Lanka. Methods: The study was conducted on a randomly selected group of community-dwelling women aged 30-60 years. ASMM (kg) quantified with dual-energy X-ray absorptiometry (DXA) (ASMMDXA) was used as the reference standard. Anthropometric measurements such as body weight (kg), height (m), limb circumferences (cm) and skinfold thickness (mm) which showed significant correlations with ASMMDXA, were used to develop the models. The models were developed...
Source: Indian J Med Res - September 1, 2019 Category: Research Authors: Rathnayake N, Alwis G, Lenora J, Lekamwasam S Tags: Indian J Med Res Source Type: research

Detection of respiratory syncytial virus & Mycoplasma pneumoniae in paediatric lower respiratory tract infections.
Detection of respiratory syncytial virus & Mycoplasma pneumoniae in paediatric lower respiratory tract infections. Indian J Med Res. 2019 Sep;150(3):306-309 Authors: Kumar S, Chakravarti A, Kumar S, Kapoor S Abstract Background & objectives: Respiratory syncytial virus (RSV) and Mycoplasma pneumoniae are considered common cause of lower respiratory tract infections (LRTIs) in children. The present study was conducted to detect M. pneumoniae and RSV in paediatric LRTIs employing serology, polymerase chain reaction (PCR) and reverse transcriptase PCR (RT-PCR) analysis. Methods: Seventy five...
Source: Indian J Med Res - September 1, 2019 Category: Research Authors: Kumar S, Chakravarti A, Kumar S, Kapoor S Tags: Indian J Med Res Source Type: research

Diffuse large B-cell lymphoma presenting as shoulder swelling.
PMID: 31719303 [PubMed - in process] (Source: Indian J Med Res)
Source: Indian J Med Res - September 1, 2019 Category: Research Authors: Sarma YS, Sriharibabu M Tags: Indian J Med Res Source Type: research

Regional cardiac tamponade.
PMID: 31719304 [PubMed - in process] (Source: Indian J Med Res)
Source: Indian J Med Res - September 1, 2019 Category: Research Authors: Gopalakrishnan A, Pillai VV Tags: Indian J Med Res Source Type: research

Erratum: Nutrition rehabilitation of children with severe acute malnutrition: Revisiting studies undertaken by the National Institute of Nutrition.
Authors: Abstract [This corrects the article DOI: 10.4103/ijmr.IJMR_1905_18]. PMID: 31719305 [PubMed - in process] (Source: Indian J Med Res)
Source: Indian J Med Res - September 1, 2019 Category: Research Tags: Indian J Med Res Source Type: research

Influenza vaccination: Some clinical concerns for South Asian practitioner.
PMID: 31670264 [PubMed - in process] (Source: Indian J Med Res)
Source: Indian J Med Res - August 1, 2019 Category: Research Authors: Wiwanitkit V Tags: Indian J Med Res Source Type: research

The thymoma tale.
PMID: 31670265 [PubMed - in process] (Source: Indian J Med Res)
Source: Indian J Med Res - August 1, 2019 Category: Research Authors: Vaideeswar P Tags: Indian J Med Res Source Type: research

Essential to update medical training after amendments to Anti-Rape Law.
PMID: 31670266 [PubMed - in process] (Source: Indian J Med Res)
Source: Indian J Med Res - August 1, 2019 Category: Research Authors: Math SB, Harbishettar V Tags: Indian J Med Res Source Type: research

Tuberculous meningitis in children: Clinical management & outcome.
Tuberculous meningitis in children: Clinical management & outcome. Indian J Med Res. 2019 Aug;150(2):117-130 Authors: Daniel BD, Grace GA, Natrajan M Abstract Although the occurrence of tuberculous meningitis (TBM) in children is relatively rare, but it is associated with higher rates of mortality and severe morbidity. The peak incidence of TBM occurs in younger children who are less than five years of age, and most children present with late-stage disease. Confirmation of diagnosis is often difficult, and other infectious causes such as bacterial, viral and fungal causes must be ruled out. Bacter...
Source: Indian J Med Res - August 1, 2019 Category: Research Authors: Daniel BD, Grace GA, Natrajan M Tags: Indian J Med Res Source Type: research

Improving survival with tuberculosis & HIV treatment integration: A mini-review.
Improving survival with tuberculosis & HIV treatment integration: A mini-review. Indian J Med Res. 2019 Aug;150(2):131-138 Authors: Naidoo K, Rampersad S, Karim SA Abstract Tuberculosis (TB) is a leading cause of morbidity and mortality among HIV-infected patients while HIV remains a key risk factor for the development of active TB infection. Treatment integration is a key in reducing mortality in patients with HIV-TB co-infection. However, this opportunity to improve outcomes of both infections is often missed or poorly implemented. Challenges in TB-HIV treatment integration range from complexiti...
Source: Indian J Med Res - August 1, 2019 Category: Research Authors: Naidoo K, Rampersad S, Karim SA Tags: Indian J Med Res Source Type: research

Nutrition rehabilitation of children with severe acute malnutrition: Revisiting studies undertaken by the National Institute of Nutrition.
Abstract Severe acute malnutrition (SAM) in children under five years is an important public health problem due to associated high mortality and long-term health consequences. Research on the dietary causes of SAM, especially the role and relative importance of dietary protein, in the aetiology of oedematous malnutrition, has led to considerable debates and controversies. The present article revisits some of the debates in this field, where the researchers at the National Institute of Nutrition (NIN), Hyderabad, India, with their pioneering work, have contributed to the global literature on the various facets of t...
Source: Indian J Med Res - August 1, 2019 Category: Research Authors: Kulkarni B, Mamidi RS Tags: Indian J Med Res Source Type: research

Histotyping of Indian thymomas: A clinicopathologic study from north India.
This study was aimed to assess the histomorphology of TETs in the Indian patients and correlate clinical parameters with pathological features. Methods: It was a retrospective study conducted in a tertiary referral hospital in north India. All morphologically confirmed cases of TETs since 2009 were included. Clinical details and histology slides were reviewed using the Modified Masaoka-Koga staging system and WHO 2015 classification. Clinicopathological correlation and survival analysis were done. A comparative review from other published Indian studies was performed. Results: A total of 219 cases of TETs (138 re...
Source: Indian J Med Res - August 1, 2019 Category: Research Authors: Guleria P, Parshad R, Malik PS, Ray R, Pandey RM, Jain D Tags: Indian J Med Res Source Type: research

Wide range of F cell levels in healthy Thai adults: Influence of Swiss-type hereditary persistence of foetal haemoglobin & β-haemoglobinopathy.
This study was conducted to determine the F cell distribution in adult Thai blood donors and to assess the possible involvement of β-thalassaemia and haemoglobin E (HbE) carriers in increased HbF levels. Methods: Thai blood donors (n=375, 205 males and 170 females) were included in the study. Blood samples were collected for measuring haemoglobin (Hb) concentration and haematocrit (Hct) and F cell levels. Hb and Hct levels were determined by automated blood counter, while F cells were quantified by flow cytometric analysis of F cells stained by fluorescein isothiocyanate-conjugated anti γ-globin monoclonal ...
Source: Indian J Med Res - August 1, 2019 Category: Research Authors: Tatu T Tags: Indian J Med Res Source Type: research

High-intensity exercise-induced oxidative stress in sedentary pre-pubertal & post-pubertal boys: A comparative study.
High-intensity exercise-induced oxidative stress in sedentary pre-pubertal & post-pubertal boys: A comparative study. Indian J Med Res. 2019 Aug;150(2):167-174 Authors: Chaki B, Pal S, Chattopadhyay S, Bandyopadhyay A Abstract Background & objectives: High-intensity exercise results in oxidative stress in adult population. Impact of pubertal attainment on high-intensity exercise-induced oxidative stress in sedentary paediatric population has not been investigated in detail. The present study was conducted to investigate the extent of high-intensity exercise-induced oxidative stress in sedentar...
Source: Indian J Med Res - August 1, 2019 Category: Research Authors: Chaki B, Pal S, Chattopadhyay S, Bandyopadhyay A Tags: Indian J Med Res Source Type: research

Antibiotic stewardship initiative in a Medicine unit of a tertiary care teaching hospital in India: A pilot study.
Abstract Background & objectives: The models for implementation of antibiotic stewardship programme (ASP) in the acute care settings of developing countries are lacking. In most of the hospitals, patient turnover is high and a proper system for recording antibiotic-related information and tracking hospital-acquired infections is not in place. This pilot study was conducted in a tertiary care teaching hospital in north India to assess the feasibility of implementation of an ASP in a Medicine unit and to evaluate the effect of implementation as per the criteria applicable in this set up. Methods: A pre-post...
Source: Indian J Med Res - August 1, 2019 Category: Research Authors: Swamy A, Sood R, Kapil A, Vikram NK, Ranjan P, Jadon RS, Soneja M, Sreenivas V Tags: Indian J Med Res Source Type: research

Kinetics of viral RNA, immunoglobulin-M & G antibodies in Kyasanur forest disease.
This study demonstrated the presence of KFD viral RNA till 18th POD, IgM antibodies till 122nd POD and IgG till the last sample collected. Based on our study an algorithm was recommended for accurate laboratory diagnosis of KFDV infection. A sample collected between 1 and 3 POD can be tested using KFDV real-time reverse transcriptase polymerase chain reaction (RT-PCR); between 4 and 24 POD, the combination of real-time RT-PCR and anti-KFDV IgM enzyme-linked immunosorbent assay (ELISA) tests can be used; between POD 25 and 132, anti-KFDV IgM and IgG ELISA are recommended. PMID: 31670274 [PubMed - in process] (Source: Indian J Med Res)
Source: Indian J Med Res - August 1, 2019 Category: Research Authors: Yadav PD, Gurav YK, Shete AM, Jain R, Nyayanit DA, Pardeshi PG, Viswanathan R, Chiplunkar TR, Awate P, Majumdar TP, Sahay RR, Mourya DT Tags: Indian J Med Res Source Type: research

Detection of heterogeneous vancomycin-intermediate Staphylococcus aureus: A preliminary report from south India.
Abstract Background & objectives: Although there are reports of heterogeneous vancomycin-intermediate Staphylococcus aureus (hVISA) across the globe, there is a lack of reliable data on hVISA in India. The present study was undertaken to determine the rate of hVISA among the methicillin-resistant Staphylococcus aureus (MRSA) isolates, and to compare the brain heart infusion agar with vancomycin 4 μg/ml (BHIV4) method with population analysis profile-area under the curve (PAP-AUC) method for the detection of hVISA and to study the distribution of mobile genetic element that carries methicillin-resistance gen...
Source: Indian J Med Res - August 1, 2019 Category: Research Authors: Amberpet R, Sistla S, Sugumar M, Nagasundaram N, Manoharan M, Parija SC Tags: Indian J Med Res Source Type: research

A community-based cross-sectional study on hypertension screening in Puducherry, India.
Abstract Background & objectives: Hypertension is a health problem of global priority. Screening and early diagnosis is important to plan appropriate interventions. The present study objectives were to screen the urban population aged 30 yr and above and diagnose for hypertension and to identify the factors associated with poor screening for hypertension, if any. Methods: A community-based descriptive cross-sectional study was conducted in urban field practice area of a tertiary care hospital in Puducherry, India, among individuals aged 30 yr and above. Individuals were asked if they have tested themselve...
Source: Indian J Med Res - August 1, 2019 Category: Research Authors: Datta S, Sahu SK, Niranjjan R, Roy G Tags: Indian J Med Res Source Type: research

Seroprevalence of typhus group rickettsial infections in the north-east region of India.
PMID: 31670277 [PubMed - in process] (Source: Indian J Med Res)
Source: Indian J Med Res - August 1, 2019 Category: Research Authors: Khan SA, Bora T, Saikia J, Shah A, Richards AL, Chattopadhyay S, Kakati S, Rahi M, Kaur H Tags: Indian J Med Res Source Type: research

Erythroderma secondary to pityriasis rubra pilaris.
PMID: 31670278 [PubMed - in process] (Source: Indian J Med Res)
Source: Indian J Med Res - August 1, 2019 Category: Research Authors: Gomez-Moyano E, Crespo-Erchiga A Tags: Indian J Med Res Source Type: research

Raise awareness of the global burden of viral hepatitis & to influence real change.
Raise awareness of the global burden of viral hepatitis & to influence real change. Indian J Med Res. 2019 Jul;150(1):1-3 Authors: Kar P PMID: 31571623 [PubMed - in process] (Source: Indian J Med Res)
Source: Indian J Med Res - July 1, 2019 Category: Research Authors: Kar P Tags: Indian J Med Res Source Type: research

Innovations in tuberculosis diagnostics: How far are we from reaching our goal?
PMID: 31571624 [PubMed - in process] (Source: Indian J Med Res)
Source: Indian J Med Res - July 1, 2019 Category: Research Authors: Varma-Basil M, Bose M Tags: Indian J Med Res Source Type: research

Corneal transplantation in the modern era.
Abstract Corneal blindness is one of the major causes of reversible blindness, which can be managed with transplantation of a healthy donor cornea. It is the most successful organ transplantation in the human body as cornea is devoid of vasculature, minimizing the risk of graft rejection. The first successful transplant was performed by Zirm, and since then, corneal transplantation has seen significant evolution. It has been possible because of the relentless efforts by researchers and the increase in knowledge about corneal anatomy, improvement in instruments and advancements in technology. Keratoplasty has come ...
Source: Indian J Med Res - July 1, 2019 Category: Research Authors: Singh R, Gupta N, Vanathi M, Tandon R Tags: Indian J Med Res Source Type: research

Adhesion molecules facilitate host-pathogen interaction & mediate Mycobacterium tuberculosis pathogenesis.
Adhesion molecules facilitate host-pathogen interaction & mediate Mycobacterium tuberculosis pathogenesis. Indian J Med Res. 2019 Jul;150(1):23-32 Authors: Bisht D, Meena LS Abstract Most of the microorganisms display adhesion molecules on their surface which help them to bind and interact with the host cell during infection. Adhesion molecules help mycobacteria to colonize and invade immune system of the host, and also trigger immune response explicated by the host against the infection. Hence, understanding the signalling pathways illustrated by these molecules to enhance our knowledge on mycoba...
Source: Indian J Med Res - July 1, 2019 Category: Research Authors: Bisht D, Meena LS Tags: Indian J Med Res Source Type: research

Rapid detection of drug-resistant Mycobacterium tuberculosis directly from clinical specimens using allele-specific polymerase chain reaction assay.
Abstract Background & objectives: Rapid detection of drug resistance in Mycobacterium tuberculosis (MTB) is essential for the efficient control of tuberculosis. Hence, in this study a nested-allele-specific (NAS) PCR, nested multiple allele-specific PCR (NMAS-PCR) and multiple allele-specific (MAS) PCR assays were evaluated that enabled detection of the most common mutations responsible for isoniazid (INH) and rifampicin (RIF) resistance in MTB isolates directly from clinical specimens. Methods: Six pairs of primers, mutated and wild type, were used for the six targets such as codon 516, 526 and 531 of rp...
Source: Indian J Med Res - July 1, 2019 Category: Research Authors: Sinha P, Banerjee T, Srivastava GN, Anupurba S Tags: Indian J Med Res Source Type: research

Association between reduced brain-derived neurotrophic factor concentration & coronary heart disease.
This study was aimed to evaluate if plasma BDNF concentration was associated with CHD in ethnically homogeneous groups of patients and to correlate plasma BDNF levels with known risk factors for CHD. Methods: Plasma BDNF concentration, BDNF Val66Met polymorphism and other biological and anthropological risk factors for CHD were determined in 208 patients with CHD and 156 healthy controls. Results: Plasma BDNF concentration was significantly (P
Source: Indian J Med Res - July 1, 2019 Category: Research Authors: Sustar A, Perkovic MN, Erjavec GN, Strac DS, Pivac N Tags: Indian J Med Res Source Type: research

Aspirin & clopidogrel non-responsiveness & its association with genetic polymorphisms in patients with myocardial infarction.
Aspirin & clopidogrel non-responsiveness & its association with genetic polymorphisms in patients with myocardial infarction. Indian J Med Res. 2019 Jul;150(1):50-61 Authors: Pandey CP, Misra A, Negi MPS, Kanuri BN, Chhonker YS, Bhatta RS, Narain VS, Dikshit M Abstract Background & objectives: Cytochrome P450, P2Y 12, cyclooxygenase-1 (COX1) and glycoprotein V1 (GPVI) gene polymorphisms are known to affect patient responsiveness towards aspirin and clopidogrel dual antiplatelet therapy (DAPT). The present study was undertaken to identify aspirin and clopidogrel non-responsiveness and its a...
Source: Indian J Med Res - July 1, 2019 Category: Research Authors: Pandey CP, Misra A, Negi MPS, Kanuri BN, Chhonker YS, Bhatta RS, Narain VS, Dikshit M Tags: Indian J Med Res Source Type: research

Non-invasive prenatal rhesus D genotyping using cell-free foetal DNA.
Abstract Background & objectives: Non-invasive prenatal diagnosis (NIPD) of rhesus D (RHD) genotype using cell-free foetal DNA is extensively used in many developed countries. Studies on NIPD from India are scarce. The aim of the present study was to evaluate the performance of non-invasive foetal RHD genotyping by targeting exon 10 of the RHD gene using cell-free DNA. Methods: DNA was extracted from the maternal plasma of alloimmunized and non-alloimmunized women between 7 and 34 wk of gestation. RHD sequence was determined by quantitative real time polymerase chain reaction (PCR). Results were compared ...
Source: Indian J Med Res - July 1, 2019 Category: Research Authors: Rather RA, Dhawan V, Saha SC Tags: Indian J Med Res Source Type: research

A comparative study on erlotinib & gefitinib therapy in non-small cell lung carcinoma patients.
This study included 71 NSCLC patients who received EGFR-TKIs between 2013 and 2016. Adverse drug reaction of both erlotinib (n=37) and gefitinib (n=34) was determined and graded according to Common Terminology Criteria for Adverse Events grading system. Effectiveness was measured using response evaluation criteria in solid tumours and progression-free survival (PFS). Pharmacoeconomic analysis was performed by cost-effective analysis. Results: When comparing safety profile, both the drugs had similar adverse events except for dermal side effects such as acneiform eruption (51.4%), rash (54.05%) and mucositis (59.5%) fo...
Source: Indian J Med Res - July 1, 2019 Category: Research Authors: Thomas P, Vincent B, George C, Joshua JM, Pavithran K, Vijayan M Tags: Indian J Med Res Source Type: research

Repetitive transcranial magnetic stimulation in chronic tension-type headache: A pilot study.
Abstract Background & objectives: Tension-type headache (TTH) is the most common type of primary headache disorder. Its chronic form is often the most ignored and challenging to treat. Transcranial magnetic stimulation (TMS) is a novel technique in the treatment of chronic pain. The aim of this pilot study was to explore the effect of low-frequency repetitive TMS (rTMS) on pain status in chronic TTH (CTTH) by subjective and objective pain assessment. Methods: Patients (n=30) diagnosed with CTTH were randomized into rTMS (n=15) and placebo (n=15) groups in this study. Pre-intervention detailed history of p...
Source: Indian J Med Res - July 1, 2019 Category: Research Authors: Mattoo B, Tanwar S, Bhatia R, Tripathi M, Bhatia R Tags: Indian J Med Res Source Type: research

Safety & efficacy of an intravasal, one-time injectable & non-hormonal male contraceptive (RISUG): A clinical experience.
Safety & efficacy of an intravasal, one-time injectable & non-hormonal male contraceptive (RISUG): A clinical experience. Indian J Med Res. 2019 Jul;150(1):81-86 Authors: Sharma RS, Mathur AK, Singh R, Das HC, Singh GJ, Toor DPS, Guha SK Abstract Background & objectives: For improved male contraception, a new polymeric drug molecule - Reversible Inhibition of Sperm under Guidance (RISUG) has been synthesized and has been found to be effective, safe and reversible in various animal species. Phase-I and phase-II clinical trials have confirmed its safety and contraceptive efficacy. The presen...
Source: Indian J Med Res - July 1, 2019 Category: Research Authors: Sharma RS, Mathur AK, Singh R, Das HC, Singh GJ, Toor DPS, Guha SK Tags: Indian J Med Res Source Type: research

Surveillance for enterotoxigenic & enteropathogenic Escherichia coli isolates from animal source foods in Northwest Iran.
This study was undertaken to identify enterotoxigenic Escherichia coli (ETEC) and enteropathogenic E. coli (EPEC) pathotypes in animal-source foods (ASF). Methods: A total of 222 ASF samples were investigated. Based on the culture and biochemical tests, 109 E. coli isolates were identified. Duplex-polymerase chain reaction assay was used to detect ETEC and EPEC. The target genes selected for each category were the lt and st for the ETEC, and eae and bfp for the EPEC isolates. Results: The occurrence of E. coli in dairy and meat products was 45 and 52.5 per cent, respectively. Among the E. coli isolates, two ETEC,...
Source: Indian J Med Res - July 1, 2019 Category: Research Authors: Abri R, Javadi A, Asghari R, Razavilar V, Salehi TZ, Safaeeyan F, Rezaee MA Tags: Indian J Med Res Source Type: research

Serovar diversity of Salmonella among poultry.
The objective of the present study was to assess the distribution of Salmonella serovars among poultry. Methods: The isolates received at National Salmonella and Escherichia Centre during 2011-2016 were subjected to biochemical identification, followed by serological characterization to identify the Salmonella serovars, and the data were presented to exhibit the distribution of Salmonella serovars among poultry. Results: Salmonella was found to be present in poultry in all the regions included in the study. Salmonella Typhimurium, S. Gallinarum and S. Enteritidis were the most prevalent serovars accounting for 96...
Source: Indian J Med Res - July 1, 2019 Category: Research Authors: Kumar Y, Singh V, Kumar G, Gupta NK, Tahlan AK Tags: Indian J Med Res Source Type: research

Molecular & serological study of dengue virus-infected patients attending a tertiary hospital of Dhaka city, Bangladesh (2013 to 2016).
Molecular & serological study of dengue virus-infected patients attending a tertiary hospital of Dhaka city, Bangladesh (2013 to 2016). Indian J Med Res. 2019 Jul;150(1):96-100 Authors: Akther T, Muraduzzaman AKM, Parvin SM, Tabssum S, Munshi SU PMID: 31571636 [PubMed - in process] (Source: Indian J Med Res)
Source: Indian J Med Res - July 1, 2019 Category: Research Authors: Akther T, Muraduzzaman AKM, Parvin SM, Tabssum S, Munshi SU Tags: Indian J Med Res Source Type: research

Primary parachordoma in the trachea: An unusual cause of dyspnoea.
PMID: 31571637 [PubMed - in process] (Source: Indian J Med Res)
Source: Indian J Med Res - July 1, 2019 Category: Research Authors: Zhang QC, Zhang XJ Tags: Indian J Med Res Source Type: research

Butterfly rash, dental staining & painful nails in a child.
Butterfly rash, dental staining & painful nails in a child. Indian J Med Res. 2019 Jul;150(1):103-104 Authors: Bishnoi A, Vinay K PMID: 31571638 [PubMed - in process] (Source: Indian J Med Res)
Source: Indian J Med Res - July 1, 2019 Category: Research Authors: Bishnoi A, Vinay K Tags: Indian J Med Res Source Type: research

Drug misuse in India: Where do we stand & where to go from here?
Drug misuse in India: Where do we stand & where to go from here? Indian J Med Res. 2019 Jun;149(6):689-692 Authors: Avasthi A, Ghosh A PMID: 31496520 [PubMed - in process] (Source: Indian J Med Res)
Source: Indian J Med Res - June 1, 2019 Category: Research Authors: Avasthi A, Ghosh A Tags: Indian J Med Res Source Type: research

Progress in multiple myeloma.
PMID: 31496521 [PubMed - in process] (Source: Indian J Med Res)
Source: Indian J Med Res - June 1, 2019 Category: Research Authors: Munker R, Monohan G Tags: Indian J Med Res Source Type: research