Cardiovascular manifestations of COVID-19: An evidence-based narrative review
Indian J Med Res. 2021 Jan & Feb;153(1 & 2):7-16. doi: 10.4103/ijmr.IJMR_2450_20.ABSTRACTThe recent outbreak of coronavirus disease 2019 (COVID-19) was declared a pandemic by the World Health Organization on March 11, 2020. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of COVID-19, primarily involves the respiratory system with viral pneumonia as a predominant manifestation. In addition, SARS-CoV-2 has various cardiovascular manifestations which increase morbidity and mortality in COVID-19. Patients with underlying cardiovascular diseases and conventional cardiovascular risk fact...
Source: Indian J Med Res - April 5, 2021 Category: Research Authors: Yash Paul Sharma Sourabh Agstam Ashutosh Yadav Anunay Gupta Ankur Gupta Source Type: research

An overview of preclinical animal models for SARS-CoV-2 pathogenicity
Indian J Med Res. 2021 Jan & Feb;153(1 & 2):17-25. doi: 10.4103/ijmr.IJMR_3215_20.ABSTRACTSevere acute respiratory syndrome coronavirus (SARS-CoV)-2 has caused millions of fatalities globally since its origin in November 2019. The SARS-CoV-2 shares 79 and 50 per cent genome similarity with its predecessors, severe SARS-CoV and Middle East respiratory syndrome (MERS) coronavirus, all belonging to the same genus, Betacoronavirus. This relatively new virus has stymied the effective control of COVID-19 pandemic and caused huge social and economic impact worldwide. The FDA-approved drugs were re-purposed to reduce the n...
Source: Indian J Med Res - April 5, 2021 Category: Research Authors: Itti Munshi Aditya Khandvilkar Shrinivas M Chavan Geetanjali Sachdeva Smita D Mahale Uddhav K Chaudhari Source Type: research

Emerging trends from COVID-19 research registered in the Clinical Trials Registry - India
Indian J Med Res. 2021 Jan & Feb;153(1 & 2):26-63. doi: 10.4103/ijmr.IJMR_2556_20.ABSTRACTSince the beginning of the year, the deadly coronavirus pandemic, better known as coronavirus disease 2019 (COVID-19), brought the entire world to an unprecedented halt. In tandem with the global scenario, researchers in India are actively engaged in the conduct of clinical research to counter the pandemic. This review attempts to provide a comprehensive overview of the COVID-19 research in India including design aspects, through the clinical trials registered in the Clinical Trials Registry - India (CTRI) till June 5, 2020. O...
Source: Indian J Med Res - April 5, 2021 Category: Research Authors: M Vishnu Vardhana Rao Atul Juneja Mohua Maulik Tulsi Adhikari Saurabh Sharma Jyotsna Gupta Yashmin Panchal Neha Yadav Source Type: research

Use of convalescent plasma for COVID-19 in India: A review & amp; practical guidelines
Indian J Med Res. 2021 Jan & Feb;153(1 & 2):64-85. doi: 10.4103/ijmr.IJMR_3092_20.ABSTRACTConvalescent plasma (CP) therapy is one of the promising therapies being tried for COVID-19 patients. This passive immunity mode involves separating preformed antibodies against SARS-CoV-2 from a recently recovered COVID-19 patient and infusing it into a patient with active disease or an exposed individual for prophylaxis. Its advantages include ease of production, rapid deployment, specificity against the target infectious agent, and scalability. In the current pandemic, it has been used on a large scale across the globe and ...
Source: Indian J Med Res - April 5, 2021 Category: Research Authors: Niranjan Shiwaji Khaire Nishant Jindal Lakshmi Narayana Yaddanapudi Suchet Sachdev Rekha Hans Naresh Sachdeva Mini P Singh Anup Agarwal Aparna Mukherjee Gunjan Kumar Ratti Ram Sharma Vikas Suri Goverdhan Dutt Puri Pankaj Malhotra Source Type: research

Demographic & amp; clinical profile of patients with COVID-19 at a tertiary care hospital in north India
CONCLUSIONS: Majority of the patients with COVID-19 infection presenting to our hospital were young and asymptomatic. Fever was noted only in three-fourth of the patients and respiratory symptoms in half of them. Patients with comorbidities were more vulnerable to complications. Triaged classification of patients and protocol-based treatment resulted in good outcomes and low case fatality.PMID:33818468 | DOI:10.4103/ijmr.IJMR_2311_20 (Source: Indian J Med Res)
Source: Indian J Med Res - April 5, 2021 Category: Research Authors: Shiv Lal Soni Kamal Kajal L N Yaddanapudi Pankaj Malhotra Goverdhan Dutt Puri Ashish Bhalla Mini P Singh Inderpaul Singh Sehgal Vipin Koushal Neelam Varma Manisha Biswal P V M Lakshmi Sadhna Sharma Vikas Suri Z Deepy Sant Ram Jaivinder Yadav Navin Pandey Source Type: research

Rapid chromatographic immunoassay-based evaluation of COVID-19: A cross-sectional, diagnostic test accuracy study & amp; its implications for COVID-19 management in India
CONCLUSIONS: With an excellent specificity and moderate sensitivity, this RDT may be used to rule in COVID-19 in patients with a duration of illness ≤5 days. Large-scale testing based on this RDT across the country would result in quick detection, isolation and treatment of COVID-19 patients.PMID:33818469 | DOI:10.4103/ijmr.IJMR_3305_20 (Source: Indian J Med Res)
Source: Indian J Med Res - April 5, 2021 Category: Research Authors: Ankesh Gupta Surbhi Khurana Rojaleen Das Deepankar Srigyan Amit Singh Ankit Mittal Parul Singh Manish Soneja Arvind Kumar Akhil Kant Singh Kapil Dev Soni Suneeta Meena Richa Aggarwal Neha Sharad Anivita Aggarwal Harshith Kadnur Netto George Komal Singh De Source Type: research

Drug repurposing for identification of potential inhibitors against SARS-CoV-2 spike receptor-binding domain: An < em > in silico < /em > approach
CONCLUSIONS: In the current investigation, simeprevir was identified as the potential antiviral drug based on the in silico findings in comparison to remdesivir, favipiravir and other 53 drugs. Further, laboratory and clinical investigations are needed to be carried out which will aid in the development of quick therapeutics designed for COVID-19.PMID:33818470 | DOI:10.4103/ijmr.IJMR_1132_20 (Source: Indian J Med Res)
Source: Indian J Med Res - April 5, 2021 Category: Research Authors: Santosh Kumar Behera Namita Mahapatra Chandra Sekhar Tripathy Sanghamitra Pati Source Type: research

Performance evaluation of Truenat ™ Beta CoV & amp; Truenat ™ SARS-CoV-2 point-of-care assays for coronavirus disease 2019
CONCLUSIONS: Truenat Beta CoV and Truenat SARS-CoV-2 assays showed concordance with the reference standard assay and may be recommended for screening and confirmation of SARS-CoV-2 in the field settings.PMID:33818471 | DOI:10.4103/ijmr.IJMR_2363_20 (Source: Indian J Med Res)
Source: Indian J Med Res - April 5, 2021 Category: Research Authors: Shantala Gowdara Basawarajappa Ambica Rangaiah Shashiraja Padukone Pragya D Yadav Nivedita Gupta Sathyanarayan Muthur Shankar Source Type: research

Chloroquine nasal drops in asymptomatic & amp; mild COVID-19: An exploratory randomized clinical trial
Indian J Med Res. 2021 Jan & Feb;153(1 & 2):151-158. doi: 10.4103/ijmr.IJMR_3665_20.ABSTRACTBACKGROUND & OBJECTIVES: Chloroquine (CQN) administered as nasal drops has the potential to achieve much greater local tissue levels than with oral/systemic administration. This trial was undertaken to study the efficacy and safety profile of topical nasal administration of CQN drops in reducing viral load and preventing clinical progression in early COVID-19 infection.METHODS: This randomized clinical trial was done with a sample size of 60. Reverse transcription-polymerase chain reaction (RT-PCR) confirmed asymptomatic...
Source: Indian J Med Res - April 5, 2021 Category: Research Authors: Alok Thakar Smriti Panda Pirabu Sakthivel Megha Brijwal Shivram Dhakad Avinash Choudekar Anupam Kanodia Sushma Bhatnagar Anant Mohan Subir K Maulik Lalit Dar Source Type: research

SARS-CoV-2 detection in sewage samples: Standardization of method & amp; preliminary observations
CONCLUSIONS: PEG-dextran phase separation method was effectively used to concentrate SARS-CoV-2 from domestic waste waters to detection levels. It would be feasible to initiate sewage surveillance for SARS-CoV-2 to generate data about the viral transmission in various epidemiologic settings.PMID:33818473 | DOI:10.4103/ijmr.IJMR_3541_20 (Source: Indian J Med Res)
Source: Indian J Med Res - April 5, 2021 Category: Research Authors: Deepa Kailash Sharma Uma Prajwal Nalavade Kamlesh Kalgutkar Nivedita Gupta Jagadish Mohanrao Deshpande Source Type: research

Phylogenetic classification of the whole-genome sequences of SARS-CoV-2 from India & amp; evolutionary trends
CONCLUSIONS: This study interpreted the geographical and temporal dominance of SARS-CoV-2 strains in India over a period of nine months based on the GISAID classification. An integration of the GISAID, Nextstrain and Pangolin classifications is also provided. The emergence of new lineages B.1.1.8 and B.1.113 was indicative of host-specific evolution of the SARS-CoV-2 strains in India. The hotspot mutations such as those driven by positive selection need to be further characterized.PMID:33818474 | DOI:10.4103/ijmr.IJMR_3418_20 (Source: Indian J Med Res)
Source: Indian J Med Res - April 5, 2021 Category: Research Authors: Varsha Potdar Veena Vipat Ashwini Ramdasi Santosh Jadhav Jayashri Pawar-Patil Atul Walimbe Sucheta S Patil Manohar L Choudhury Jayanthi Shastri Sachee Agrawal Shailesh Pawar Kavita Lole Priya Abraham Sarah Cherian ICMR-NIV NIC Team Source Type: research

Prediction of potential small interfering RNA molecules for silencing of the spike gene of SARS-CoV-2
Indian J Med Res. 2021 Jan & Feb;153(1 & 2):182-189. doi: 10.4103/ijmr.IJMR_2855_20.NO ABSTRACTPMID:33818475 | DOI:10.4103/ijmr.IJMR_2855_20 (Source: Indian J Med Res)
Source: Indian J Med Res - April 5, 2021 Category: Research Authors: Kingshuk Panda Kalichamy Alagarasu Sarah S Cherian Deepti Parashar Source Type: research

Inactivation of SARS-CoV-2 by gamma irradiation
Indian J Med Res. 2021 Jan & Feb;153(1 & 2):196-198. doi: 10.4103/ijmr.IJMR_2789_20.NO ABSTRACTPMID:33818476 | DOI:10.4103/ijmr.IJMR_2789_20 (Source: Indian J Med Res)
Source: Indian J Med Res - April 5, 2021 Category: Research Authors: Rajlaxmi Jain Prasad Sarkale Deepak Mali Anita M Shete Deepak Y Patil Triparna Majumdar Annasaheb Suryawanshi Savita Patil Sreelekshmy Mohandas Pragya D Yadav Source Type: research

Authors' response
Indian J Med Res. 2021 Jan & Feb;153(1 & 2):200. doi: 10.4103/0971-5916.307214.NO ABSTRACTPMID:33818477 | DOI:10.4103/0971-5916.307214 (Source: Indian J Med Res)
Source: Indian J Med Res - April 5, 2021 Category: Research Authors: Parul Chawla Gupta Praveen Kumar M Jagat Ram Source Type: research

Authors' response
Indian J Med Res. 2021 Jan & Feb;153(1 & 2):204-206. doi: 10.4103/0971-5916.307699.NO ABSTRACTPMID:33818478 | DOI:10.4103/0971-5916.307699 (Source: Indian J Med Res)
Source: Indian J Med Res - April 5, 2021 Category: Research Authors: Manindra Agrawal Madhuri Kanitkar M Vidyasagar Source Type: research

COVID-19 & amp; HIV/AIDS pandemics: Parallels & amp; lessons
Indian J Med Res. 2021 Jan & Feb;153(1 & 2):214-218. doi: 10.4103/ijmr.IJMR_2598_20.NO ABSTRACTPMID:33818479 | DOI:10.4103/ijmr.IJMR_2598_20 (Source: Indian J Med Res)
Source: Indian J Med Res - April 5, 2021 Category: Research Authors: Natasha Dawa Jai Prakash Narain Source Type: research

Safety of hydroxychloroquine in healthcare workers for COVID-19 prophylaxis
CONCLUSIONS: HCQ prophylaxis first dose was well tolerated among HCWs as evidenced by a low discontinuation. For adverse effects, a small number required treatment, and none required hospitalization. The study had limitations of convenience sampling and lack of laboratory and electrocardiography confirmation of AEs.PMID:33818480 | DOI:10.4103/ijmr.IJMR_2294_20 (Source: Indian J Med Res)
Source: Indian J Med Res - April 5, 2021 Category: Research Authors: Atiya R Faruqui Denis Xavier Sandhya K Kamat Sujith J Chandy Bikash Medhi Raakhi K Tripathi Yashashri C Shetty John Michael Raj Sandeep Kaushal S Balakrishnan Shubham Atal Santanu K Tripathi Dinesh K Badyal Harihar Dikshit Sukalyan Saha Roy Niyati Trivedi Source Type: research

Feasibility, efficiency & amp; effectiveness of pooled sample testing strategy (pooled NAAT) for molecular testing of COVID-19
CONCLUSIONS: It was observed that testing samples for COVID-19 by reverse transcription (RT)- PCR after pooling could be a cost-effective method which would save both in manpower and cost especially for resource-poor countries and at a time when test kits were short in supply.PMID:33818481 | DOI:10.4103/ijmr.IJMR_2333_20 (Source: Indian J Med Res)
Source: Indian J Med Res - April 5, 2021 Category: Research Authors: Shantanu Prakash Om Prakash Hricha Mishra Danish N Khan Suruchi Shukla Ajay Pandey Kiran Rade Nivedita Gupta M L B Bhatt Amita Jain Source Type: research

Focussing on 'mental hygiene' along with 'hand hygiene' in the times of COVID-19
Indian J Med Res. 2021 Jan & Feb;153(1 & 2):238-240. doi: 10.4103/ijmr.IJMR_2960_20.NO ABSTRACTPMID:33818482 | DOI:10.4103/ijmr.IJMR_2960_20 (Source: Indian J Med Res)
Source: Indian J Med Res - April 5, 2021 Category: Research Authors: Mahadev Singh Sen Nishtha Chawla Rajesh Sagar Source Type: research

Cardiovascular manifestations of COVID-19: An evidence-based narrative review
Indian J Med Res. 2021 Jan & Feb;153(1 & 2):7-16. doi: 10.4103/ijmr.IJMR_2450_20.ABSTRACTThe recent outbreak of coronavirus disease 2019 (COVID-19) was declared a pandemic by the World Health Organization on March 11, 2020. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of COVID-19, primarily involves the respiratory system with viral pneumonia as a predominant manifestation. In addition, SARS-CoV-2 has various cardiovascular manifestations which increase morbidity and mortality in COVID-19. Patients with underlying cardiovascular diseases and conventional cardiovascular risk fact...
Source: Indian J Med Res - April 5, 2021 Category: Research Authors: Yash Paul Sharma Sourabh Agstam Ashutosh Yadav Anunay Gupta Ankur Gupta Source Type: research

An overview of preclinical animal models for SARS-CoV-2 pathogenicity
Indian J Med Res. 2021 Jan & Feb;153(1 & 2):17-25. doi: 10.4103/ijmr.IJMR_3215_20.ABSTRACTSevere acute respiratory syndrome coronavirus (SARS-CoV)-2 has caused millions of fatalities globally since its origin in November 2019. The SARS-CoV-2 shares 79 and 50 per cent genome similarity with its predecessors, severe SARS-CoV and Middle East respiratory syndrome (MERS) coronavirus, all belonging to the same genus, Betacoronavirus. This relatively new virus has stymied the effective control of COVID-19 pandemic and caused huge social and economic impact worldwide. The FDA-approved drugs were re-purposed to reduce the n...
Source: Indian J Med Res - April 5, 2021 Category: Research Authors: Itti Munshi Aditya Khandvilkar Shrinivas M Chavan Geetanjali Sachdeva Smita D Mahale Uddhav K Chaudhari Source Type: research

Emerging trends from COVID-19 research registered in the Clinical Trials Registry - India
Indian J Med Res. 2021 Jan & Feb;153(1 & 2):26-63. doi: 10.4103/ijmr.IJMR_2556_20.ABSTRACTSince the beginning of the year, the deadly coronavirus pandemic, better known as coronavirus disease 2019 (COVID-19), brought the entire world to an unprecedented halt. In tandem with the global scenario, researchers in India are actively engaged in the conduct of clinical research to counter the pandemic. This review attempts to provide a comprehensive overview of the COVID-19 research in India including design aspects, through the clinical trials registered in the Clinical Trials Registry - India (CTRI) till June 5, 2020. O...
Source: Indian J Med Res - April 5, 2021 Category: Research Authors: M Vishnu Vardhana Rao Atul Juneja Mohua Maulik Tulsi Adhikari Saurabh Sharma Jyotsna Gupta Yashmin Panchal Neha Yadav Source Type: research

Use of convalescent plasma for COVID-19 in India: A review & amp; practical guidelines
Indian J Med Res. 2021 Jan & Feb;153(1 & 2):64-85. doi: 10.4103/ijmr.IJMR_3092_20.ABSTRACTConvalescent plasma (CP) therapy is one of the promising therapies being tried for COVID-19 patients. This passive immunity mode involves separating preformed antibodies against SARS-CoV-2 from a recently recovered COVID-19 patient and infusing it into a patient with active disease or an exposed individual for prophylaxis. Its advantages include ease of production, rapid deployment, specificity against the target infectious agent, and scalability. In the current pandemic, it has been used on a large scale across the globe and ...
Source: Indian J Med Res - April 5, 2021 Category: Research Authors: Niranjan Shiwaji Khaire Nishant Jindal Lakshmi Narayana Yaddanapudi Suchet Sachdev Rekha Hans Naresh Sachdeva Mini P Singh Anup Agarwal Aparna Mukherjee Gunjan Kumar Ratti Ram Sharma Vikas Suri Goverdhan Dutt Puri Pankaj Malhotra Source Type: research

Demographic & amp; clinical profile of patients with COVID-19 at a tertiary care hospital in north India
CONCLUSIONS: Majority of the patients with COVID-19 infection presenting to our hospital were young and asymptomatic. Fever was noted only in three-fourth of the patients and respiratory symptoms in half of them. Patients with comorbidities were more vulnerable to complications. Triaged classification of patients and protocol-based treatment resulted in good outcomes and low case fatality.PMID:33818468 | DOI:10.4103/ijmr.IJMR_2311_20 (Source: Indian J Med Res)
Source: Indian J Med Res - April 5, 2021 Category: Research Authors: Shiv Lal Soni Kamal Kajal L N Yaddanapudi Pankaj Malhotra Goverdhan Dutt Puri Ashish Bhalla Mini P Singh Inderpaul Singh Sehgal Vipin Koushal Neelam Varma Manisha Biswal P V M Lakshmi Sadhna Sharma Vikas Suri Z Deepy Sant Ram Jaivinder Yadav Navin Pandey Source Type: research

Rapid chromatographic immunoassay-based evaluation of COVID-19: A cross-sectional, diagnostic test accuracy study & amp; its implications for COVID-19 management in India
CONCLUSIONS: With an excellent specificity and moderate sensitivity, this RDT may be used to rule in COVID-19 in patients with a duration of illness ≤5 days. Large-scale testing based on this RDT across the country would result in quick detection, isolation and treatment of COVID-19 patients.PMID:33818469 | DOI:10.4103/ijmr.IJMR_3305_20 (Source: Indian J Med Res)
Source: Indian J Med Res - April 5, 2021 Category: Research Authors: Ankesh Gupta Surbhi Khurana Rojaleen Das Deepankar Srigyan Amit Singh Ankit Mittal Parul Singh Manish Soneja Arvind Kumar Akhil Kant Singh Kapil Dev Soni Suneeta Meena Richa Aggarwal Neha Sharad Anivita Aggarwal Harshith Kadnur Netto George Komal Singh De Source Type: research

Drug repurposing for identification of potential inhibitors against SARS-CoV-2 spike receptor-binding domain: An < em > in silico < /em > approach
CONCLUSIONS: In the current investigation, simeprevir was identified as the potential antiviral drug based on the in silico findings in comparison to remdesivir, favipiravir and other 53 drugs. Further, laboratory and clinical investigations are needed to be carried out which will aid in the development of quick therapeutics designed for COVID-19.PMID:33818470 | DOI:10.4103/ijmr.IJMR_1132_20 (Source: Indian J Med Res)
Source: Indian J Med Res - April 5, 2021 Category: Research Authors: Santosh Kumar Behera Namita Mahapatra Chandra Sekhar Tripathy Sanghamitra Pati Source Type: research

Performance evaluation of Truenat ™ Beta CoV & amp; Truenat ™ SARS-CoV-2 point-of-care assays for coronavirus disease 2019
CONCLUSIONS: Truenat Beta CoV and Truenat SARS-CoV-2 assays showed concordance with the reference standard assay and may be recommended for screening and confirmation of SARS-CoV-2 in the field settings.PMID:33818471 | DOI:10.4103/ijmr.IJMR_2363_20 (Source: Indian J Med Res)
Source: Indian J Med Res - April 5, 2021 Category: Research Authors: Shantala Gowdara Basawarajappa Ambica Rangaiah Shashiraja Padukone Pragya D Yadav Nivedita Gupta Sathyanarayan Muthur Shankar Source Type: research

Chloroquine nasal drops in asymptomatic & amp; mild COVID-19: An exploratory randomized clinical trial
Indian J Med Res. 2021 Jan & Feb;153(1 & 2):151-158. doi: 10.4103/ijmr.IJMR_3665_20.ABSTRACTBACKGROUND & OBJECTIVES: Chloroquine (CQN) administered as nasal drops has the potential to achieve much greater local tissue levels than with oral/systemic administration. This trial was undertaken to study the efficacy and safety profile of topical nasal administration of CQN drops in reducing viral load and preventing clinical progression in early COVID-19 infection.METHODS: This randomized clinical trial was done with a sample size of 60. Reverse transcription-polymerase chain reaction (RT-PCR) confirmed asymptomatic...
Source: Indian J Med Res - April 5, 2021 Category: Research Authors: Alok Thakar Smriti Panda Pirabu Sakthivel Megha Brijwal Shivram Dhakad Avinash Choudekar Anupam Kanodia Sushma Bhatnagar Anant Mohan Subir K Maulik Lalit Dar Source Type: research

SARS-CoV-2 detection in sewage samples: Standardization of method & amp; preliminary observations
CONCLUSIONS: PEG-dextran phase separation method was effectively used to concentrate SARS-CoV-2 from domestic waste waters to detection levels. It would be feasible to initiate sewage surveillance for SARS-CoV-2 to generate data about the viral transmission in various epidemiologic settings.PMID:33818473 | DOI:10.4103/ijmr.IJMR_3541_20 (Source: Indian J Med Res)
Source: Indian J Med Res - April 5, 2021 Category: Research Authors: Deepa Kailash Sharma Uma Prajwal Nalavade Kamlesh Kalgutkar Nivedita Gupta Jagadish Mohanrao Deshpande Source Type: research

Phylogenetic classification of the whole-genome sequences of SARS-CoV-2 from India & amp; evolutionary trends
CONCLUSIONS: This study interpreted the geographical and temporal dominance of SARS-CoV-2 strains in India over a period of nine months based on the GISAID classification. An integration of the GISAID, Nextstrain and Pangolin classifications is also provided. The emergence of new lineages B.1.1.8 and B.1.113 was indicative of host-specific evolution of the SARS-CoV-2 strains in India. The hotspot mutations such as those driven by positive selection need to be further characterized.PMID:33818474 | DOI:10.4103/ijmr.IJMR_3418_20 (Source: Indian J Med Res)
Source: Indian J Med Res - April 5, 2021 Category: Research Authors: Varsha Potdar Veena Vipat Ashwini Ramdasi Santosh Jadhav Jayashri Pawar-Patil Atul Walimbe Sucheta S Patil Manohar L Choudhury Jayanthi Shastri Sachee Agrawal Shailesh Pawar Kavita Lole Priya Abraham Sarah Cherian ICMR-NIV NIC Team Source Type: research

Prediction of potential small interfering RNA molecules for silencing of the spike gene of SARS-CoV-2
Indian J Med Res. 2021 Jan & Feb;153(1 & 2):182-189. doi: 10.4103/ijmr.IJMR_2855_20.NO ABSTRACTPMID:33818475 | DOI:10.4103/ijmr.IJMR_2855_20 (Source: Indian J Med Res)
Source: Indian J Med Res - April 5, 2021 Category: Research Authors: Kingshuk Panda Kalichamy Alagarasu Sarah S Cherian Deepti Parashar Source Type: research

Inactivation of SARS-CoV-2 by gamma irradiation
Indian J Med Res. 2021 Jan & Feb;153(1 & 2):196-198. doi: 10.4103/ijmr.IJMR_2789_20.NO ABSTRACTPMID:33818476 | DOI:10.4103/ijmr.IJMR_2789_20 (Source: Indian J Med Res)
Source: Indian J Med Res - April 5, 2021 Category: Research Authors: Rajlaxmi Jain Prasad Sarkale Deepak Mali Anita M Shete Deepak Y Patil Triparna Majumdar Annasaheb Suryawanshi Savita Patil Sreelekshmy Mohandas Pragya D Yadav Source Type: research

Authors' response
Indian J Med Res. 2021 Jan & Feb;153(1 & 2):200. doi: 10.4103/0971-5916.307214.NO ABSTRACTPMID:33818477 | DOI:10.4103/0971-5916.307214 (Source: Indian J Med Res)
Source: Indian J Med Res - April 5, 2021 Category: Research Authors: Parul Chawla Gupta Praveen Kumar M Jagat Ram Source Type: research

Authors' response
Indian J Med Res. 2021 Jan & Feb;153(1 & 2):204-206. doi: 10.4103/0971-5916.307699.NO ABSTRACTPMID:33818478 | DOI:10.4103/0971-5916.307699 (Source: Indian J Med Res)
Source: Indian J Med Res - April 5, 2021 Category: Research Authors: Manindra Agrawal Madhuri Kanitkar M Vidyasagar Source Type: research

COVID-19 & amp; HIV/AIDS pandemics: Parallels & amp; lessons
Indian J Med Res. 2021 Jan & Feb;153(1 & 2):214-218. doi: 10.4103/ijmr.IJMR_2598_20.NO ABSTRACTPMID:33818479 | DOI:10.4103/ijmr.IJMR_2598_20 (Source: Indian J Med Res)
Source: Indian J Med Res - April 5, 2021 Category: Research Authors: Natasha Dawa Jai Prakash Narain Source Type: research

Safety of hydroxychloroquine in healthcare workers for COVID-19 prophylaxis
CONCLUSIONS: HCQ prophylaxis first dose was well tolerated among HCWs as evidenced by a low discontinuation. For adverse effects, a small number required treatment, and none required hospitalization. The study had limitations of convenience sampling and lack of laboratory and electrocardiography confirmation of AEs.PMID:33818480 | DOI:10.4103/ijmr.IJMR_2294_20 (Source: Indian J Med Res)
Source: Indian J Med Res - April 5, 2021 Category: Research Authors: Atiya R Faruqui Denis Xavier Sandhya K Kamat Sujith J Chandy Bikash Medhi Raakhi K Tripathi Yashashri C Shetty John Michael Raj Sandeep Kaushal S Balakrishnan Shubham Atal Santanu K Tripathi Dinesh K Badyal Harihar Dikshit Sukalyan Saha Roy Niyati Trivedi Source Type: research

Feasibility, efficiency & amp; effectiveness of pooled sample testing strategy (pooled NAAT) for molecular testing of COVID-19
CONCLUSIONS: It was observed that testing samples for COVID-19 by reverse transcription (RT)- PCR after pooling could be a cost-effective method which would save both in manpower and cost especially for resource-poor countries and at a time when test kits were short in supply.PMID:33818481 | DOI:10.4103/ijmr.IJMR_2333_20 (Source: Indian J Med Res)
Source: Indian J Med Res - April 5, 2021 Category: Research Authors: Shantanu Prakash Om Prakash Hricha Mishra Danish N Khan Suruchi Shukla Ajay Pandey Kiran Rade Nivedita Gupta M L B Bhatt Amita Jain Source Type: research

Focussing on 'mental hygiene' along with 'hand hygiene' in the times of COVID-19
Indian J Med Res. 2021 Jan & Feb;153(1 & 2):238-240. doi: 10.4103/ijmr.IJMR_2960_20.NO ABSTRACTPMID:33818482 | DOI:10.4103/ijmr.IJMR_2960_20 (Source: Indian J Med Res)
Source: Indian J Med Res - April 5, 2021 Category: Research Authors: Mahadev Singh Sen Nishtha Chawla Rajesh Sagar Source Type: research

Cardiovascular manifestations of COVID-19: An evidence-based narrative review
Indian J Med Res. 2021 Jan & Feb;153(1 & 2):7-16. doi: 10.4103/ijmr.IJMR_2450_20.ABSTRACTThe recent outbreak of coronavirus disease 2019 (COVID-19) was declared a pandemic by the World Health Organization on March 11, 2020. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of COVID-19, primarily involves the respiratory system with viral pneumonia as a predominant manifestation. In addition, SARS-CoV-2 has various cardiovascular manifestations which increase morbidity and mortality in COVID-19. Patients with underlying cardiovascular diseases and conventional cardiovascular risk fact...
Source: Indian J Med Res - April 5, 2021 Category: Research Authors: Yash Paul Sharma Sourabh Agstam Ashutosh Yadav Anunay Gupta Ankur Gupta Source Type: research

An overview of preclinical animal models for SARS-CoV-2 pathogenicity
Indian J Med Res. 2021 Jan & Feb;153(1 & 2):17-25. doi: 10.4103/ijmr.IJMR_3215_20.ABSTRACTSevere acute respiratory syndrome coronavirus (SARS-CoV)-2 has caused millions of fatalities globally since its origin in November 2019. The SARS-CoV-2 shares 79 and 50 per cent genome similarity with its predecessors, severe SARS-CoV and Middle East respiratory syndrome (MERS) coronavirus, all belonging to the same genus, Betacoronavirus. This relatively new virus has stymied the effective control of COVID-19 pandemic and caused huge social and economic impact worldwide. The FDA-approved drugs were re-purposed to reduce the n...
Source: Indian J Med Res - April 5, 2021 Category: Research Authors: Itti Munshi Aditya Khandvilkar Shrinivas M Chavan Geetanjali Sachdeva Smita D Mahale Uddhav K Chaudhari Source Type: research

Emerging trends from COVID-19 research registered in the Clinical Trials Registry - India
Indian J Med Res. 2021 Jan & Feb;153(1 & 2):26-63. doi: 10.4103/ijmr.IJMR_2556_20.ABSTRACTSince the beginning of the year, the deadly coronavirus pandemic, better known as coronavirus disease 2019 (COVID-19), brought the entire world to an unprecedented halt. In tandem with the global scenario, researchers in India are actively engaged in the conduct of clinical research to counter the pandemic. This review attempts to provide a comprehensive overview of the COVID-19 research in India including design aspects, through the clinical trials registered in the Clinical Trials Registry - India (CTRI) till June 5, 2020. O...
Source: Indian J Med Res - April 5, 2021 Category: Research Authors: M Vishnu Vardhana Rao Atul Juneja Mohua Maulik Tulsi Adhikari Saurabh Sharma Jyotsna Gupta Yashmin Panchal Neha Yadav Source Type: research

Use of convalescent plasma for COVID-19 in India: A review & amp; practical guidelines
Indian J Med Res. 2021 Jan & Feb;153(1 & 2):64-85. doi: 10.4103/ijmr.IJMR_3092_20.ABSTRACTConvalescent plasma (CP) therapy is one of the promising therapies being tried for COVID-19 patients. This passive immunity mode involves separating preformed antibodies against SARS-CoV-2 from a recently recovered COVID-19 patient and infusing it into a patient with active disease or an exposed individual for prophylaxis. Its advantages include ease of production, rapid deployment, specificity against the target infectious agent, and scalability. In the current pandemic, it has been used on a large scale across the globe and ...
Source: Indian J Med Res - April 5, 2021 Category: Research Authors: Niranjan Shiwaji Khaire Nishant Jindal Lakshmi Narayana Yaddanapudi Suchet Sachdev Rekha Hans Naresh Sachdeva Mini P Singh Anup Agarwal Aparna Mukherjee Gunjan Kumar Ratti Ram Sharma Vikas Suri Goverdhan Dutt Puri Pankaj Malhotra Source Type: research

Demographic & amp; clinical profile of patients with COVID-19 at a tertiary care hospital in north India
CONCLUSIONS: Majority of the patients with COVID-19 infection presenting to our hospital were young and asymptomatic. Fever was noted only in three-fourth of the patients and respiratory symptoms in half of them. Patients with comorbidities were more vulnerable to complications. Triaged classification of patients and protocol-based treatment resulted in good outcomes and low case fatality.PMID:33818468 | DOI:10.4103/ijmr.IJMR_2311_20 (Source: Indian J Med Res)
Source: Indian J Med Res - April 5, 2021 Category: Research Authors: Shiv Lal Soni Kamal Kajal L N Yaddanapudi Pankaj Malhotra Goverdhan Dutt Puri Ashish Bhalla Mini P Singh Inderpaul Singh Sehgal Vipin Koushal Neelam Varma Manisha Biswal P V M Lakshmi Sadhna Sharma Vikas Suri Z Deepy Sant Ram Jaivinder Yadav Navin Pandey Source Type: research

Rapid chromatographic immunoassay-based evaluation of COVID-19: A cross-sectional, diagnostic test accuracy study & amp; its implications for COVID-19 management in India
CONCLUSIONS: With an excellent specificity and moderate sensitivity, this RDT may be used to rule in COVID-19 in patients with a duration of illness ≤5 days. Large-scale testing based on this RDT across the country would result in quick detection, isolation and treatment of COVID-19 patients.PMID:33818469 | DOI:10.4103/ijmr.IJMR_3305_20 (Source: Indian J Med Res)
Source: Indian J Med Res - April 5, 2021 Category: Research Authors: Ankesh Gupta Surbhi Khurana Rojaleen Das Deepankar Srigyan Amit Singh Ankit Mittal Parul Singh Manish Soneja Arvind Kumar Akhil Kant Singh Kapil Dev Soni Suneeta Meena Richa Aggarwal Neha Sharad Anivita Aggarwal Harshith Kadnur Netto George Komal Singh De Source Type: research

Drug repurposing for identification of potential inhibitors against SARS-CoV-2 spike receptor-binding domain: An < em > in silico < /em > approach
CONCLUSIONS: In the current investigation, simeprevir was identified as the potential antiviral drug based on the in silico findings in comparison to remdesivir, favipiravir and other 53 drugs. Further, laboratory and clinical investigations are needed to be carried out which will aid in the development of quick therapeutics designed for COVID-19.PMID:33818470 | DOI:10.4103/ijmr.IJMR_1132_20 (Source: Indian J Med Res)
Source: Indian J Med Res - April 5, 2021 Category: Research Authors: Santosh Kumar Behera Namita Mahapatra Chandra Sekhar Tripathy Sanghamitra Pati Source Type: research

Performance evaluation of Truenat ™ Beta CoV & amp; Truenat ™ SARS-CoV-2 point-of-care assays for coronavirus disease 2019
CONCLUSIONS: Truenat Beta CoV and Truenat SARS-CoV-2 assays showed concordance with the reference standard assay and may be recommended for screening and confirmation of SARS-CoV-2 in the field settings.PMID:33818471 | DOI:10.4103/ijmr.IJMR_2363_20 (Source: Indian J Med Res)
Source: Indian J Med Res - April 5, 2021 Category: Research Authors: Shantala Gowdara Basawarajappa Ambica Rangaiah Shashiraja Padukone Pragya D Yadav Nivedita Gupta Sathyanarayan Muthur Shankar Source Type: research

Chloroquine nasal drops in asymptomatic & amp; mild COVID-19: An exploratory randomized clinical trial
Indian J Med Res. 2021 Jan & Feb;153(1 & 2):151-158. doi: 10.4103/ijmr.IJMR_3665_20.ABSTRACTBACKGROUND & OBJECTIVES: Chloroquine (CQN) administered as nasal drops has the potential to achieve much greater local tissue levels than with oral/systemic administration. This trial was undertaken to study the efficacy and safety profile of topical nasal administration of CQN drops in reducing viral load and preventing clinical progression in early COVID-19 infection.METHODS: This randomized clinical trial was done with a sample size of 60. Reverse transcription-polymerase chain reaction (RT-PCR) confirmed asymptomatic...
Source: Indian J Med Res - April 5, 2021 Category: Research Authors: Alok Thakar Smriti Panda Pirabu Sakthivel Megha Brijwal Shivram Dhakad Avinash Choudekar Anupam Kanodia Sushma Bhatnagar Anant Mohan Subir K Maulik Lalit Dar Source Type: research

SARS-CoV-2 detection in sewage samples: Standardization of method & amp; preliminary observations
CONCLUSIONS: PEG-dextran phase separation method was effectively used to concentrate SARS-CoV-2 from domestic waste waters to detection levels. It would be feasible to initiate sewage surveillance for SARS-CoV-2 to generate data about the viral transmission in various epidemiologic settings.PMID:33818473 | DOI:10.4103/ijmr.IJMR_3541_20 (Source: Indian J Med Res)
Source: Indian J Med Res - April 5, 2021 Category: Research Authors: Deepa Kailash Sharma Uma Prajwal Nalavade Kamlesh Kalgutkar Nivedita Gupta Jagadish Mohanrao Deshpande Source Type: research

Phylogenetic classification of the whole-genome sequences of SARS-CoV-2 from India & amp; evolutionary trends
CONCLUSIONS: This study interpreted the geographical and temporal dominance of SARS-CoV-2 strains in India over a period of nine months based on the GISAID classification. An integration of the GISAID, Nextstrain and Pangolin classifications is also provided. The emergence of new lineages B.1.1.8 and B.1.113 was indicative of host-specific evolution of the SARS-CoV-2 strains in India. The hotspot mutations such as those driven by positive selection need to be further characterized.PMID:33818474 | DOI:10.4103/ijmr.IJMR_3418_20 (Source: Indian J Med Res)
Source: Indian J Med Res - April 5, 2021 Category: Research Authors: Varsha Potdar Veena Vipat Ashwini Ramdasi Santosh Jadhav Jayashri Pawar-Patil Atul Walimbe Sucheta S Patil Manohar L Choudhury Jayanthi Shastri Sachee Agrawal Shailesh Pawar Kavita Lole Priya Abraham Sarah Cherian ICMR-NIV NIC Team Source Type: research

Prediction of potential small interfering RNA molecules for silencing of the spike gene of SARS-CoV-2
Indian J Med Res. 2021 Jan & Feb;153(1 & 2):182-189. doi: 10.4103/ijmr.IJMR_2855_20.NO ABSTRACTPMID:33818475 | DOI:10.4103/ijmr.IJMR_2855_20 (Source: Indian J Med Res)
Source: Indian J Med Res - April 5, 2021 Category: Research Authors: Kingshuk Panda Kalichamy Alagarasu Sarah S Cherian Deepti Parashar Source Type: research