Nitric oxide in the COPD pathogenesis in patients with pulmonary tuberculosis
Nitric oxide (NO) is a marker of endothelial dysfunction and nitrosative stress involved in the COPD pathogenesis. The aim is to assess the role of NO in COPD pathogenesis in pulmonary tuberculosis (PT) patients.Methods: In 47 male smokers: 28 PT (1st group) and 19 patients with PT and COPD (2nd group), the pulmonary function testing and the concentration of nitrite (NO2 -), nitrate (NO3-) in serum (s), mononuclear cells (mn) and neutrophils (nf) of blood ELISA- kit were assessed.Results: In both groups, a decrease in the level of NO3-s (Me-9.4 and 14.2 mmol / l, p
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Kiryukhina, L., Dyakova, M., Esmedlyaeva, D. Tags: Mechanisms of lung injury and repair Source Type: research

Clinical characteristics of physician diagnosed asthma-COPD overlap
Conclusions: Physician-diagnosed ACO patients had highest prevalence of current-smoker and their symptoms, lung function, and eosinophil counts were between the two conditions. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Lee, H., Chung, S. J., Yeo, Y., Park, T. S., Park, D. W., Moon, J. Y., Kim, T. H., Sohn, J. W., Yoon, H. J., Kim, S.-H. Tags: Airway pharmacology and treatment Source Type: research

The Clinicoradiological Profile of Obliterative Bronchiolitis at a Tertiary Care Centre
Conclusion: OB is one of the major causes of CAO. HRCT Chest with expiratory scans plays a pivotal role in diagnosis. Early diagnosis can prevent irrevocable complications. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: H S, S., Utpat, K., Desai, U., Joshi, J. Tags: Monitoring airway disease Source Type: research

Do causes influence clinical, functional and quality of life aspects on patients with bronchiectasis not associated with cystic fibrosis?
Bronchiectasis can have different causes. Etiology impact on clinical and functional aspects is little known.Objectives: Identify causes of bronchiectasis non cystic fibrosis(BNFC) and investigate if there are differences concerning clinical, functional and of quality of life(QoL) among groups.Methods: Descriptive and cross-sectional study conducted in a Brazilian University hospital. Patients (N=109, mean age 53 yrs, 60% women) with tomographic diagnosis of bronchiectasis had medical files reviewed and were interviewed to identify personal and familial antecedents; they also performed spirometry and answered the Saint Geo...
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Cristina da Silva, A., Medeiros, J., Pereira, M. Tags: Monitoring airway disease Source Type: research

Silico-tuberculosis Association: about 40 cases
Conclusion: The rise in the prevalence and incidence of tuberculosis in silicosis. Due to some clinical and radiological similarities between silicosis and some forms of tuberculosis, diagnosis may be delayed. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Heddane, R., Djebaili, R., Djenfi, T., Djebbar, A. Tags: Occupational and environmental health Source Type: research

Influence of smoking of hookah on some indicators of respiratory system in girls of childbearing age
Conclusion: Smoking hookah in healthy girls leads to changes in the cardio-respiratory system-the increase in clinical symptoms from the respiratory and cardiovascular system the transition of peak expiratory flow rate indicators to the signal zones. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Sultanov, S., Fatima, T., Sultanova, S., Homova, N., Rafkat, F. Tags: Tobacco, smoking control and health educ. Source Type: research

Special features of pulmonary tuberculosis among smokers: A case control study
Smoking and tuberculosis (TB) represent two major health issues particularly in developing countries. Tobacco consumption increases risk of Mycobaterium tuberculosis infection among immunocompetent.Methods: A retrospective case control study carried out in the pulmonary department of military hospital of Tunis : 173 patients treated for TB were enrolled, subdivided in tow groups (G) : G1 : 106 smokers (61.3%), G2 : 67 non smokers (38.7%) . All possible data was collected.Aims: To compare the clinical course and radiological aspects of pulmonary TB between smokers and non smokers.Results: The mean age was 43 years [18 -93 y...
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Laouini, I., Mejri, I., Omrane, A., Mhamdi, S., Daboussi, S., Aichaouia, C., Khadhraoui, M., Moatemri, Z., Cheikh, R. Tags: Tobacco, smoking control and health educ. Source Type: research

Clinical characteristics and prognosis of chronic pulmonary aspergillosis
Background: Chronic pulmonary aspergillosis (CPA) is a chronic progressive infectious disease that occurs frequently in patients with underlying pulmonary disease. Only a few reports have studied the clinical characteristics and prognosis of CPA.Aims and Objectives: We aimed to investigate the clinical characteristics of CPA patients and their prognosis. We retrospectively analyzed patients diagnosed as having CPA between 2014 and 2017 in our hospital.Results: We enrolled 159 patients in this study. Of them, 115 (72.3%) patients were male, 96 (60.4%) were ex/current smokers, their median age at diagnosis was 69 years, and ...
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Nakamoto, K., Sasaki, Y., Shirai, T., Fujiwara, K., Furuuchi, K., Osawa, T., Shimoda, M., Yamana, K., Morimoto, K., Yano, R., Miyamoto, M., Kokuto, H., Tanaka, Y., Okumura, M., Uchiyama, T., Yoshimori, K., Ohta, K. Tags: Respiratory infections Source Type: research

Chronic pulmonary aspergillosis in France: prevalence, associated chronic pulmonary diseases and prognosis in a 10-year retrospective study of the French nationwide administrative hospital database
Conclusions: We report the largest retrospective nationwide cohort of patients hospitalized for CPA. In France, CPA is more commonly associated with COPD, emphysema, lung cancer or fibrosis than with TB. The alarming CPA morbidity and mortality rates observed should justify specific screening for CPA in some CPDs. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Maitre, T., Cottenet, J., Godet, C., Bonniaud, P., Quantin, C., Cadranel, J. Tags: Respiratory infections Source Type: research

Putting in Harm to cure: Drug related adverse events do not affect outcome of patients receiving treatment for Multidrug-Resistant Tuberculosis
Rationale: Treatment of multi-drug resistant Tuberculosis (MDR-TB) is challenging because it mostly relies on drugs with low efficacy and great toxicity.Objectives: To describe the frequency and type of adverse drug reactions in a cohort of MDR-TB patients.Methods: We conducted a retrospective study in a cohort of MDR-TB patients enrolled in a referral center in Italy from 2008 to 2016.Results: Seventy-four MDR-TB patients ( mean age 32 years, 58.1% males, 2 XDR, 12 pre-XDR TB) were evaluated. Median length of treatment duration was 20 months (IQR 14-24). Treatment outcome was successful in 57 patients (77%; 51 cured, 6 tr...
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Gualano, G., Mencarini, P., Musso, M., Mosti, S., Murachelli, S., Cannas, A., Di Caro, A., Goletti, D., Girardi, E., Palmieri, F. Tags: Respiratory infections Source Type: research

Endobronchial valve treatment for cavitary pulmonary diseases caused by non-tuberculosis mycobacteria
Conclusion: EBV treatment can be used successfully for closure of the cavities in NTM-PD, even if it isimpossible to carry out drug therapy. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Russkikh, A., Gracheva, A., Lovacheva, O., Vasilyeva, I. Tags: Respiratory infections Source Type: research

Pyrosequencing(PSQ) in early diagnosis of CNS tuberculosis and determining drug resistance
Conclusion: PSQ helps detecting MTB complex directly fromCSF even with negative Xpert. Early diagnosis, detection of resistance aids in administering appropriate treatment early and decrease mortality, long term disability. PSQ shows promising results in diagnosing, early detection of resistance in CNS TB. Though correlation with phenotypic DST recommended & further research warranted. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Bhosle, A., Singhal, P., Pardasani, V., Lunia, P., Ajbani, K., Dhangar, D., Tiple, S. Tags: Tuberculosis Source Type: research

A study to perceive the role and function of Proteasome Accessory Factor-C (PafC) inMycobacterium tuberculosis
Conclusion: The differential regulation of pafC gene has been observed by quantitative real-time PCR at the RNA level in the clinical samples of PTB. The over-expression and knock down clones expressing PafC were subjected for comparative profiling of primary and second-line anti-TB drugs. Protein expression of cultures that were subjected to stress was also measured. The data shows the probable role of PafC in intracellular survival. The absence of PafC in the culture filtrate and patient sera confirmed the non-secretory characteristic of the protein. The detailed results of the study will be discussed during the meeting....
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Narain, A., Dhamija, E., Srivastava, K., Srivastava, K. K., Kant, S. Tags: Tuberculosis Source Type: research

Elucidation of Protein Tyrosine Phosphatase-B for its role in intracellular survival of Mycobacterium tuberculosis
Conclusion: The proteomic data shows upregulation of a number of chaperone proteins like hsp75, hsp 70, BiP, mortalin suggesting the possible role of PtpB in regulating the stress conditions within the host to promote mycobacterial survival. Cytoskeleton binding proteins (like coronin-1, profilin-1) were also found to be upregulated showing its probable role in blocking phagosome-lysosome fusion. Its antigenic nature was confirmed by showing its presence in TB-patient sera by western blotting. Our results suggest that PtpB is secreted by mycobacteria during infection which alters host proteins in a number of ways to enhanc...
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Dhamija, E., Yabaji, S., Chatterjee, A., Mishra, A., K.Dubey, R., Narain, A., K. Srivastava, K. Tags: Tuberculosis Source Type: research

In silico validation of anti-tuberculosis activity and identification of lead molecules in Annona squamosa
Conclusion: The overall results substantiated the traditional use of Annona squamosa against TB and the identified lead molecules can be suggested for further experiments leading to the discovery of a novel drug. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Basheera, S., Sivanandan, S., Charuvilkamalan, B. Tags: Tuberculosis Source Type: research

Decreased miR-150-5p and miR-23a-3p expressions in patients with active Pulmonary Tuberculosis (TB) disease
Conclusions: MiR-150-5p and miR-23a-3p were down-regulated in active TB disease. These findings provide biological insight into mechanisms by which Mycobacterium TB-suppressed miRs modulate human immunity, and indicate that over-expression of the miR-150 and miR-23a may be a new host-directed immunotherapy for active TB. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Chen, Y.-C., Lin, M.-C., Lee, C.-P., Zheng, Y.-X., Fang, W.-F. Tags: Tuberculosis Source Type: research

The efficacy of single-photon emission computed tomography with Macrotech 99m-Tc radiopharmaceutical in microcirculation evaluation in patients with fibrous-cavernous pulmonary tuberculosis
Conclusions: Scintigraphy analysis detected in the most of the patients severe disorders of lung regional blood flow: disorders involving 4-6 zones were observed in 50% of cases, 3 zones – in 29% of cases. These patients underwent surgical treatments for fibrous-cavernous pulmonary tuberculosis. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Kazho, R., Karpina, N., Sigaev, A., Amansahedov, R. Tags: Tuberculosis Source Type: research

Serum microRNA markers of tuberculoma decoy
Introduction: Pulmonary tuberculoma is a clinical form of tuberculosis (TB) combining various encapsulated caseous foci of more than 1 cm in diameter with a long and often low-symptom course. A characteristic feature of this form is the prolonged torpid course and the presence of a pronounced connective tissue capsule surrounding large or a group of small foci of caseous and infiltrates. Tuberculoma may stay silent for years, but if progressing can develop severe forms such as caseous pneumonia, disseminated and fibrous-cavernous TB.The aim of our study was to identify serum microRNA markers of tuberculoma decoy.Methods: T...
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Evstifeev, V., Shepelkova, G., Ergeshova, A., Guskov, A., Bagirov, M., Yeremeev, V. Tags: Tuberculosis Source Type: research

The increased production level of 15 cytokines associated with tuberculosis severity and patients responsiveness to therapy
Pulmonary tuberculosis (TB) is clinically heterogeneous disease that may develop as a result of immune deficiency or immune hyperreactivity. Exact factors and markers associated with both types of immune dysfunction are not fully clear. To analyze the heterogeneity of immune reactivity of TB patients, we have analyzed the levels of 47 cytokines in the serum and antigen-induced plasma (AG-plasma) of TB patients and their associations with TB severity and responsiveness to TB treatment.Serum and AG-plasma were obtained from 37 patients with recently-diagnosed TB; cytokines were evaluated using xMAP multiplex assay. TB severi...
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Nikitina, I., Serdyuk, Y., Nenasheva, T., Bagdasaryan, T., Shorokhova, V., Lyadova, I. Tags: Tuberculosis Source Type: research

From environmental bacteria to obligate pathogen: the study of adaptations enhancing the persistence of tuberculosis bacilli
The highly contagious human pathogen Mycobacterium tuberculosis is responsible for an estimated 1.5 million deaths each year. A major feature of M. tuberculosis is its unique capacity to survive within the host for decades. In contrast, the evolutionary early-branching rare tubercle bacilli Mycobacterium canettii, which is thought to have originated from the same pool of ancestors as M. tuberculosis, rarely causes tuberculosis (TB) in humans and has a reduced capacity to persist and cause disease in the mouse model. Our objectives are to identify the genetic adaptations which allow persistence of TB bacilli within the host...
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Allen, A., Malaga, W., Astarie-Dequeker, C., Hassan, A., Berrone, C., Moreau, F., Supply, P., Brosch, R., Guilhot, C. Tags: Tuberculosis Source Type: research

Indoleamine 2,3-dioxygenase-1 (IDO1) activity protects M. tuberculosis in macrophages from antibiotics
Conclusion: We propose that IDO1 activity may be pronounced in infected macrophages that are exposed to IFN-, and attenuates effect of antibiotics.Acknowledgement: LG is funded by a CSC grant (China). (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Guo, L., Dijkhuis, A., Van Der Wel, N., Lutter, R. Tags: Tuberculosis Source Type: research

The Glutoxim influence on minimum inhibitory concentration of isoniazid-resistant strains of Mycobacterium tuberculosis
Conclusions: G reduced the MIC of isoniazid at low and high level of I-resistant strains. Dose-dependent effect G was detected: the most effective concentration was 1.6 µg/ml in which the G reduced MIC of I in 2 times. Overall, potential activity of G appears at concentrations below the level of 50 µg/ml. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Solovieva, N., Kulikova, O., Rakisheva, Z., Balasaniantc, G. Tags: Tuberculosis Source Type: research

Role of TLR2 Polymorphism (2258) in Susceptibility to Pulmonary Tuberculosis
TLR2 polymorphism is essential in the immune response to mycobacteria. It is a prospective association study based on the analysis of the distribution of alleles of a gene polymorphism between 250 adult patients and having a proven pulmonary tuberculosis and 250 controls healthy"T", and having a negative tuberculin IDR and normal chest x-ray. The mean age of the cases was 38.3+/-15.1 with a sex ratio of 1.45 while that of controls was 40.6 +/-13.4 with a sex ratio of 1.25. Matching by gender and age showed a significant difference (p 2). The distribution of polymorphisms by sex found a significantly elevated freq...
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Benbetka, Y., Saadi, K., Fissah, A. Tags: Tuberculosis Source Type: research

Study of the Association of Functional Polymorphisms Affecting the TLR2, TIRAP, TNF, IL1B, IL1RN, IL12B and NOS2A Genes with Susceptibility to Pulmonary Tuberculosis
In this study, trends were found for several polymorphisms: TLR2 + 596T/C (p=0.052 for theTC allele), TNF-308G/A(p=0.072 for the GG allele)and NOS2-277T/C(P= 0.090 for the TT allele) where as no significant value or trend towards an association was found for the polymorphisms:TLR2-16934 A/T(rs4696480), TLR2+1349T/C(rs3804100 ), TIRAP 180Ser/Leu(RS8177374), TNF-1031T/C(RS1799964), TNF-238G/A(RS361525),IL1RN 86bp VNTR,IL1B-511A/G(RS3087258),IL1B+3953G/A (RS1143634), IL 12B 1188T/G(rs3212227)and NOS2-1659G / A(rs8078340. These results suggest the importance of genetic studies on tuberculosis. The identification of these major...
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Benbetka, Y., Djami, N., Fissah, A. Tags: Tuberculosis Source Type: research

The attenuation of cytokine response might be correlated with gut dysbiosis in nontuberculous mycobacteria lung disease
Conclusions: We preliminarily found that the cytokines of PBMC response and microbiota diversity of gut were decreased in patients with NTM-LD. The gut dysbiosis might play a role in immunosuppression for pathogenesis of NTM-LD. The mechanism required further investigation. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Shu, C.-C. Tags: Tuberculosis Source Type: research

Hepatotoxic reactions in rats after administration of component schemes of reserve Anti-TB drugs with different safety profile
Conclusions: complex of 5 ATD (Bdq+Mox+Pto+Z+PAS) turned out to be less toxic for liver than combinations of 4 ATD. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Kazakov, A., Mozhokina, G., Zyuzya, Y., Petrova, L. Tags: Tuberculosis Source Type: research

Mycobacterium tuberculosis shape and size variations in alveolar macrophages of tuberculosis patients
Tuberculosis (TB) is a significant global health threat, with one-third of the world’s population infected with causative agent M. tuberculosis (Mtb). With the increasing prevalence of multidrug and extensively drug resistant (MDR and XDR) TB, there is a need to study the mechanisms of Mtb survival in patients’ alveolar macrophages. The Mtb shape and size alterations during TB disease are expected to be as the markers of virulence, specific defense against host responses and the peculiarities of microbe’s pathogenesis in individual patients.We estimated Mtb shape and size in alveolar macrophages isolated ...
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Ufimtseva, E., Eremeeva, N., Vakhrusheva, D., Skornyakov, S. Tags: Tuberculosis Source Type: research

In vitroM.tuberculosis H37Rv inhibition with levofloxacin encapsulated in PLGA particles
Conclusions: Our studies demonstrated the controlled release of LFX encapsulated in PLGA particles and its effect on MTB culture. SCF drug encapsulation eliminates the use of toxic organic solvents and high temperatures, and can be effectively applied for R&D of advanced ATD formulations.Funding: RFBR 18-29-06062 (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Antonov, E., Smirnova, T., Andreevskaya, S., Chernousova, L., Bogorodski, S., Popov, V. Tags: Tuberculosis Source Type: research

Efficiency of bactericidal activity of liposomal mycobacteriophages against intracellular Mycobacteria tuberculosis in the model of macrophages RAW 264
Introduction: The use of lytic mycobacteriophage D29 incorporated into liposomes may be one way to achieve more efficient TB treatment.Aim: To study the bactericidal effect of liposomal lytic mycobacteriophage (phage) against intracellular MTB in the model of cultured macrophages.Methods: RAW 264-7 (ATCC) macrophage cell culture was infected for 24 hours with H37RV MTB at a concentration of 107/ml. Then macrophages were isolated by centrifugation in a Ficoll-Paque density gradient. Phage D29 (minimum 108 PFU) was purified on an ion-exchange Q-sepharose column and then shaken with a phospholipid film consisting of phosphati...
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Vladimirsky, M., Lapenkova, M., Alyapkina, Y., Vasilyeva, I. Tags: Tuberculosis Source Type: research

Efficacy of anti-tuberculosis therapy with INH, RIF and Bedaquiline in mice with different genetic susceptibility to the infection
Conclusions: Efficacy of TB-drug therapy depends on genetic susceptibility of the host to TB infection. Necrotic and hypoxic lung granuloma in susceptible host can significantly abrogate drug efficacy. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Nikonenko, B., Bocharova, I., Korotetskaya, M., Kondratieva, E., Apt, A. Tags: Tuberculosis Source Type: research

Tuberculosis infection control measures assessment in diabetic healthcare facilities
Conclusion: Infection control practice to prevent airborne disease is inadequate. More work is needed to improve TB infection control measures. 7.65% of general healthcare facilities patients visited diabetic clinics. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Ameen, S., Abdulrazaq, M., Al-Farttoosi, A., Rajeb, T., Jabir, M., Thani, R. Tags: Tuberculosis Source Type: research

Tuberculosis and homeless context
Conclusion: risk factors for TB at homeless were male sex, middle adulthood, low scholarity, HIV and harmful habits, which were perceived on low success rate. Homeless should be screened annually as high risk groups. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Osipov, T., Lesnic, E. Tags: Tuberculosis Source Type: research

Roma TB patients -"double trouble": migration and lifestyle
Conclusions:– The TB incidence and infectiousness of cases from this Roma community are significantly higher than in general population;– The abroad movement of cases even during treatment is a potential factor of TB spreading in the general population and in similar communities from EU because of keeping the same life style and habits;– Persistent health care education is needed in this vulnerable group. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Sorete Arbore, A., Cojocariu, V. Tags: Tuberculosis Source Type: research

Pulmonary tuberculosis in smokers
Conclusion: according to our study, smoking is not associated to a higher risk of sequelae or recurrence of TB. However, in view of multiple ravages of smoking, especially respiratory, encouraging tobacco cessation should be a part in the global management of TB. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Narjes, A., Amani, M., Manel, L., Sonya, F., Hedia, G. Tags: Tuberculosis Source Type: research

Comparative analysis and epidemiological aspects of spreading tuberculosis strains in Kharkiv region, Eastern Ukraine
Conclusions: It is very important to use contemporary tools for epidemiological and infection control to prevent spreading dangerous strains of M.tuberculosis as Beijing which can leads to develop MDR and XDR TB. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Konstantynovska, O., Liashenko, O., Poteiko, P., Rohozhyn, A., Hrek, I., Solodiankin, O. Tags: Tuberculosis Source Type: research

Evaluation of the Integrated Tuberculosis Research Programme (PII TB) by SEPAR (Spanish Respiratory Society)
Aim: To know the evolution of the main variables related to TB and to evaluate the indicators linked to the objectives of the PII-TBMethods: Multicentric cross-sectional study of 7,107 new TB cases collected prospectively between 2006 and 2016 in a data base by PII TB (160 collaborating researchers from 101 health centers throughout the country). The analisys was performed with central trend measurements and 95% confidence intervals (CI). The p
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Rodrigo Sanz, M. T., Garcia-Garcia, J.-M., Rodriguez-Lopez, J., Cayla, J. A., Caminero Luna, J. A., Ruiz Manzano, J. Tags: Tuberculosis Source Type: research

Completion rates of LTBI treatment: shifting prescription from INH alone to RIF containing regimens. Observation from 1992 to 2017
From 1992 to 2017 our Centre prescribed 19746 LTBI preventive treatments (PT) for reasons including contact with Tb cases, immune suppression (HIV, anti-TNF etc), homeless applying to city shelters, health care worker, asylum seekers, untreated TB scars etc. Until 2010 INH alone was almost always prescribed except in contacts of INH-resistant cases, while RIF containing PT regimens progressively became a prevalent choice from 2011 on. Of the 18961 with complete records, 82,7% received isoniazid (INH) for 6 months, 15.4% combined rifampicin and isoniazid ( RIF+INH) for 3 months, and 1.9% RIF alone for 4 months. Italians wer...
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Castellotti, P. F., Ferrarese, M., Saporiti, M., Campisi, D., Besozzi, G., Villa, S., Codecasa, L. R. Tags: Tuberculosis Source Type: research

Predictive factors of delayed sputum conversion in pulmonary tuberculosis
Conclusion: Delayed sputum smear and culture conversion occurred in about 1/3 of patients. Diabetes, smoking, hemoptysis and smear grade are predictive factors of delayed sputum smear and culture conversion. These patients need special healthcare. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Slim, A., Daghfous, H., Ben Mansour, A., Kchouk, H., Ezzaouia, A., Ben Saad, S., Tritar, F. Tags: Tuberculosis Source Type: research

Tuberculosis Screening at Social Solidarity Institutions
Conclusions: The majority of the diagnoses were classified as LTBI. Therapeutic adherence was superior with the HR regimen. The diagnosis and treatment of LTBI should be well oriented, and the screening of social solidarity institutions should be a step forward in the approach to tuberculosis, helping avoiding cases of disease in the future and, consequently, transmission of the disease. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Coutinho Costa, J. E., Machado, J., Gomes, L., Brito, P., Cravo Roxo, P. Tags: Tuberculosis Source Type: research

Internal and external migrants in new TB cases in Moscow
Background: About 50% of new TB cases (NC) in Moscow city are migrants (mostly "labor migration"), internal (from other Russian regions, IM) or external (foreigners, EM), which consist of former USSR and other countries (FSC and OC) cases. FSC includes ones detected at the City Migration Center for work permition by screening (FSC-S), and passive detected cases (FSC-P).Aims: Analysis of characteristics of NC in different migrant groups.Methods: 5704 new TB cases, registered in 2017-2018 in Moscow, including 1224 IM, 1745 FSC, 113 OC and 2622 residents (RS) were analyzed. Treatment outcomes analysis based on 2017 ...
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Belilovsky, E., Borisov, S. E., Sinitsyn, M., Chizhova, A., Matveeva, M., Ilchenko, A. Tags: Tuberculosis Source Type: research

Tuberculosis and Immigration - A retrospective study at an urban Chest Disease Center
Conclusions: The high incidence rates of TB among immigrant population are mostly a reflection of the incidence rates in their countries of origin. Host countries have a responsibility to develop a deeper knowledge about health care needs of immigrants in general and particularly for TB, because of the impact of international migration on local TB epidemiology. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Braco Forte, C. I., Alfaiate, A., Carreira, S., Sousa, S., Santos, V., Duarte, P. Tags: Tuberculosis Source Type: research

Tuberculosis in elderly patients
Introduction: Elderly patients are vulnerable to infectious diseases especially tuberculosis(TB). This immunodeficiency is caused by age and comorbidities.Aim of Study: Determine the prevalence of TB in elderly and compare the clinical, bacteriologic, and radiologic features of pulmonary TB in young adults and elderly patients.Methods: Retrospective study(2011-2018) including patients with pulmonary TB and treated according to WHO recommendations in pulmonary department C (Mami hospital in Tunisia). Population was divided to 2 groups (G): G1(n=42):elderly patients(age ≥65 years old), Group 2(n=418):young patients(age
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Slim, A., Daghfous, H., Ben Mansour, A., Kchouk, H., Ezzaouia, A., Ben Saad, S., Tritar, F. Tags: Tuberculosis Source Type: research

Psychiatric disorders in women with tuberculosis: A questionnaire based study at tertiary care hospital
Conclusion: Efforts to enhance the gender sensitivity of health services and to promote community awareness of TB. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Srivastava, K., Bajpai, J., Narain, A., Tripathi, A., Kant, S. Tags: Tuberculosis Source Type: research

Benefits of a municipality tuberculosis screening program among socially vulnerable citizens
Conclusions: TB screening among socially vulnerable citizens is feasible and can identify TB thereby possibly reducing its spread. Future TB screening should primarily focus on sputum analysis. Identification of comorbidities resulted in additional investigations and early diagnosis of e.g. cancer. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Smidt Hansen, T., Oldenborg, L., Bendstrup, E. Tags: Tuberculosis Source Type: research

Influence of genotype of MBT on the method of detecting tuberculosis
The hereditary properties defines the ability of MBT to penetrate into a person and multiply, causing a complex of pathological processes: inflammatory symptoms, bacterial excretion, destruction of lung tissue. These characteristics of the infection may change the way in which patients with tuberculosis (TB) are identified. The goal: a comparison of the clinical manifestations of TB and methods for its detection in groups of patients formed from individuals secreting MBT with different genotype. Materials. We analyzed to detect the disease, the presence of MBT and lung destruction. The first group took patients (n=93) with...
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Tereshin, V., Tyulkova, T., Umpeleva, T., Yeremeeva, N., Vakhrusheva, D., Belousova, K., Guseva, V. Tags: Tuberculosis Source Type: research

Belarus experience in video observed treatment for tuberculosis patients
Conclusions: Our data on VOT demonstrate high levels of treatment adherence and excellent treatment outcomes among a diverse types of TB patients in Belarus. In light of national system transition from in-hospital to out-patient based TB care the experience gained can promote further expansion of VOT. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Skrahina, A., Grankov, V., Hurevich, H., Klimuk, D., Akulov, V., Dara, M. Tags: Tuberculosis Source Type: research

Cigarette smoke is a risk factor for severity destructive processes in patients with pulmonary tuberculosis
It is known that matrix metalloproteinases (MMPs) are the biomarkers of the inflammation process in pulmonary tuberculosis (TB). Our goal is to investigate how tobacco smoking (TS) affects the MMPs dynamics at TB without comorbid COPD.Methods: Patients with a verified TB diagnosis were divided into 3 groups, that included never-smokers (I gr., n=45), current-smokers (II gr., n=99) and ex-smokers (III gr., n=21). Spirometry was performed by MasterScreen-Body, volume of focuses (VF, mm3) were estimated using the Vitrea station (by Nodule Analysis program), the blood concentration of key MMPs (MMP-1,-8,-9) and their inhibitor...
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Esmedlyaeva, D., Kiryukhina, L., Nefedova, N., Gavrilov, P., Dyakova, M., Yablonskii, P. Tags: Tuberculosis Source Type: research

Clinical characteristics and economic burden of Tuberculous-destroyed lung: a National Health Insurance Service-National Sample Cohort based study
Conclusions: TDL impose high medical economic burden. The estimated economic costs had been developed mainly by inpatient services and medication prescriptionsThis study was supported by a grant of the Ministry of Health and Welfare, Republic of Korea (Grant No. HC16C-2254-010017). (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Yoo, K. H., Park, Y. B., Lee, W.-Y., Oh, Y.-M., Rhee, C. K. Tags: Tuberculosis Source Type: research

Factors affecting the efficacy of treatment of MDR/XDR TB patients receiving bedaquiline
Objective: Define the impact of various factors on the efficacy of treatment of MDR/XDR TB patients receiving Bq.Materials and Methods: 360 culture-positive MDR/XDR pulmonary TB patients which was registered for treatment in 2015 from 56 regions of Russia. All of the patients received Bq. For statistical data analysis the logistic regression method with step-by-step 2-way algorithm of adding/excluding factors (excluding interactions) to obtain the lowest value of AIC was used. The following factors were analyzed: individual anti-TB drugs included in the treatment regimen, regardless of the duration of use and combination w...
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Samoilova, A., Kirianova, E., Shcherbakov, O., Glebov, K., Russkikh, A., Vasilyeva, I. Tags: Tuberculosis Source Type: research

Clinical features of XDR-TB patients
Background: Understanding the clinical features of XDR-TB makes it possible to identify its predictors and organize the treatment of these patients.Methods: analyzed and compared records of patients with XDR-TB (708), MDR-TB, excludes XDR-TB (3469) and drug-sensitive TB (4320) by registration group, age, gender, presence of HIV, proportion of rural population, frequency of bacterial excretion by smear microscopy.Results: In the XDR-TB group, patients prevailed after treatment failure (67.5% compared to 48.9% in the MDR-TB group and 5.6% in the drug-sensitive TB group; p 0.05), 1.9% for drug-susceptible TB. The median age i...
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Rusakova, L., Sterlikov, S., Galkin, V. Tags: Tuberculosis Source Type: research