Tuberculosis: experts question evidence and safety data used to approve latest drug
(Source: BMJ News)
Source: BMJ News - December 5, 2019 Category: General Medicine Source Type: research

The effect of tuberculosis on immune reconstitution among HIV patients on highly active antiretroviral therapy in Adigrat general hospital, eastern Tigrai, Ethiopia; 2019: a retrospective follow up study
Ethiopia initiated antiretroviral therapy early in 2005. Managing and detecting antiretroviral treatment response is important to monitor the effectiveness of medication and possible drug switching for low imm... (Source: BMC Immunology)
Source: BMC Immunology - December 5, 2019 Category: Allergy & Immunology Authors: Hadush Negash, Haftom Legese, Mebrahtu Tefera, Fitsum Mardu, Kebede Tesfay, Senait Gebresilasie, Berhane Fseha, Tsega Kahsay, Aderajew Gebrewahd and Brhane Berhe Tags: Research article Source Type: research

Data quality of drug-resistant tuberculosis and antiretroviral therapy electronic registers in South Africa
To assess the quality and completeness of treatment and outcome data in the electronic tuberculosis (TB) and antiretroviral treatment (ART) registers in drug-resistant (DR-) TB patients at three treatment faci... (Source: BMC Public Health)
Source: BMC Public Health - December 5, 2019 Category: Consumer Health News Authors: Lise Jamieson, Denise Evans, Rebecca Berhanu, Nazir Ismail, Samantha Aucock, Kristina Wallengren and Lawrence Long Tags: Research article Source Type: research

Psychological changes and associated factors among patients with tuberculosis who received directly observed treatment short-course in metropolitan areas of Japan: quantitative and qualitative perspectives
The directly observed treatment short-course (DOTS) is one of the most effective tuberculosis (TB) control measures worldwide. However, despite its aim of providing comprehensive and humanistic care, few studi... (Source: BMC Public Health)
Source: BMC Public Health - December 5, 2019 Category: Consumer Health News Authors: Kae Nagahiro Shiratani Tags: Research article Source Type: research

Molecular characterization of multidrug-resistant Mycobacterium tuberculosis (MDR-TB) isolates identifies local transmission of infection in Kuwait, a country with a low incidence of TB and MDR-TB
ConclusionsOur study provides the first insight into molecular epidemiology of MDR-TB in Kuwait and identified several potential clusters of local transmission of MDR-TB involving 2 –6 subjects which had escaped detection by routine surveillance studies. Prospective detection of resistance-conferring mutations can identify possible cases of local transmission of MDR-TB in low MDR-TB settings. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - December 5, 2019 Category: Research Source Type: research

Treatment and recurrence on re-treatment tuberculosis patients: a randomized clinical trial and 7-year perspective cohort study in China
This study aimed to examine the therapeutic effects of new re-treatment regimens, and explore risk factors associated with recurrence after successful treatment. We conducted a cohort study in nine regions of China and enrolled previously treated TB patients from October, 2008 to December, 2010. Patients were randomly divided into four treatment regimen groups including standard, high-dose, long-course, and individualized treatment. After treatment, those with successful treatment outcomes were followed up to 7  years. The effects of different regimens and the information of recurrence were recorded. Risk factors to p...
Source: European Journal of Clinical Microbiology and Infectious Diseases - December 5, 2019 Category: Microbiology Source Type: research

Potential Active Targeting of Gatifloxacin to Macrophages by Means of Surface-Modified PLGA Microparticles Destined to Treat Tuberculosis.
ido A Abstract Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis and represents one of the leading causes of mortality worldwide due to multidrug-resistant TB (MDR-TB). In our work, a new formulation of biodegradable PLGA microparticles was developed for pulmonary administration of gatifloxacin, using a surface modifier agent to actively target alveolar macrophages thereby allowing to gain access of the drug to Mycobacterium tuberculosis. For this, rapid uptake of the particles by macrophages is beneficial. This process was evaluated with fluorescein-loaded microparticles using PLGA 5...
Source: AAPS PharmSciTech - December 5, 2019 Category: Drugs & Pharmacology Authors: Marcianes P, Negro S, Barcia E, Montejo C, Fernández-Carballido A Tags: AAPS PharmSciTech Source Type: research

Integrating data of veterinarians’ practices in assessing the cost effectiveness of three components of the bovine tuberculosis surveillance system by intradermal tuberculin testing in French cattle farms through a scenario-tree approach
Publication date: Available online 3 December 2019Source: Research in Veterinary ScienceAuthor(s): V. Gétin-Poirier, G. Crozet, S. Gardon, B. Dufour, J. RivièreAbstractDisease surveillance systems’ effectiveness relies on participants following prescribed practices. We developed a general method to improve a previous cost-effectiveness evaluation of three French screening program protocols for bovine tuberculosis (bTB) to account for the practices of participants by scenario tree modelling. This method relies on: 1) semi-directive interviews of participants to identify the variability of practices and p...
Source: Research in Veterinary Science - December 4, 2019 Category: Veterinary Research Source Type: research

Rv2223c, an acid inducible carboxyl-esterase of Mycobacterium tuberculosis enhanced the growth and survival of Mycobacterium smegmatis
Future Microbiology, Ahead of Print. (Source: Future Microbiology)
Source: Future Microbiology - December 4, 2019 Category: Microbiology Authors: Pratibha Maan Jagdeep Kaur Source Type: research

Reprogramming of MAIT Cells to Pluripotency and Redifferentiation.
Abstract Reprogramming differentiated cells into induced pluripotent stem cells (iPSCs) consists in dedifferentiation of the cells into the pluripotent state, i.e., stem cells. Since T cells play a pivotal role in our immune system, T cell reprogramming into iPSCs and subsequent redifferentiation of iPSCs toward the original cells hold a great promise for future cell therapy and for further exploring the biology of such T cells. Mucosal-associated invariant T (MAIT) cells are an innate-like T cells linking innate immunity to adaptive immunity, and believed to be implicated in host protection to infection, in infla...
Source: Mol Biol Cell - December 4, 2019 Category: Molecular Biology Authors: Wakao H Tags: Methods Mol Biol Source Type: research

Telemedicine Technologies and Tuberculosis Management: A Randomized Controlled Trial
Telemedicine and e-Health, Ahead of Print. (Source: Telemedicine and e-Health)
Source: Telemedicine and e-Health - December 4, 2019 Category: Information Technology Authors: Peng Guo Wei Qiao Ying Sun Fenglin Liu Chunting Wang Source Type: research

A Novel Genetic Variation in NCF2, the Core Component of NADPH Oxidase, Contributes to the Susceptibility of Tuberculosis in Western Chinese Han Population
DNA and Cell Biology, Ahead of Print. (Source: DNA and Cell Biology)
Source: DNA and Cell Biology - December 4, 2019 Category: Cytology Authors: Lin Jiao Jiajia Song Liu Ding Tangyuheng Liu Tao Wu Jingwei Zhang Hao Bai Hao Chen Zhenzhen Zhao Binwu Ying Source Type: research

[ASAP] Polypropionate Derivatives with < italic toggle="yes" > Mycobacterium tuberculosis < /italic > Protein Tyrosine Phosphatase B Inhibitory Activities from the Deep-Sea-Derived Fungus < italic toggle="yes" > Aspergillus fischeri < /italic > FS452
Journal of Natural ProductsDOI: 10.1021/acs.jnatprod.9b00834 (Source: Journal of Natural Products)
Source: Journal of Natural Products - December 4, 2019 Category: Biochemistry Authors: Zhaoming Liu †?, Qinglin Wang‡?, Saini Li†, Hui Cui§, Zhanghua Sun§, Dongni Chen‡, Yongjun Lu*‡, Hongxin Liu*†, and Weimin Zhang*† Source Type: research

Epidemiological Impact of Targeted Interventions for People with Diabetes Mellitus on Tuberculosis Transmission in India: Modelling Based Predictions
ConclusionGains can be attained by targeting DM individuals with interventions to reduce TB burden. Most strategies were effective with
Source: Epidemics - December 4, 2019 Category: Epidemiology Source Type: research

Inhibition of type I interferon signaling abrogates early Mycobacterium bovis infection
Mycobacterium bovis (M. bovis) is the principal causative agent of bovine tuberculosis; however, it may also cause serious infection in human being. Type I IFN is a key factor in reducing viral multiplication and... (Source: BMC Infectious Diseases)
Source: BMC Infectious Diseases - December 4, 2019 Category: Infectious Diseases Authors: Jie Wang, Tariq Hussain, Kai Zhang, Yi Liao, Jiao Yao, Yinjuan Song, Naveed Sabir, Guangyu Cheng, Haodi Dong, Miaoxuan Li, Jiamin Ni, Mazhar Hussain Mangi, Deming Zhao and Xiangmei Zhou Tags: Research article Source Type: research

Prevalence of tuberculosis, HIV/AIDS, and hepatitis; in a prison of Balochistan: a cross-sectional survey
Human Immunodeficiency Virus (HIV), Hepatitis, and Tuberculosis (TB) are three primary communicable infections have the likely potential to cause severe morbidity in prison settings. The prison has the most fa... (Source: BMC Public Health)
Source: BMC Public Health - December 4, 2019 Category: Consumer Health News Authors: Ahmad Wali, Dawood Khan, Nauman Safdar, Zeenat Shawani, Razia Fatima, Aashifa Yaqoob, Aurangzeb Qadir, Sultan Ahmed, Hamayun Rashid, Bashir Ahmed and Shereen Khan Tags: Research article Source Type: research

Reverse zoonotic tuberculosis transmission from an emerging Uganda I strain between pastoralists and cattle in South-Eastern Nigeria
This study was aimed at using molecular tools to establish... (Source: BMC Veterinary Research)
Source: BMC Veterinary Research - December 4, 2019 Category: Veterinary Research Authors: Hezekiah Kehinde Adesokan, Victor Oluwatoyin Akinseye, Elizabeth Maria Streicher, Paul Van Helden, Rob Mark Warren and Simeon Idowu Cadmus Tags: Research article Source Type: research

Advances in the Diagnosis and Management of Tubercular Meningitis in Children
AbstractTubercular meningitis (TBM) continues to be a common cause of neuromorbidity in children. There is no single diagnostic method that can rapidly detectMycobacterium tuberculosis (M.tb) in TBM patients with high sensitivity and specificity. Newer diagnostic modalities like Xpert/RIF assay  and Loop mediated isothermal amplification assay (LAMP) have gained an essential stand in molecular diagnostics due to their high specificity, modest sensitivity in cerebrospinal fluid (CSF) and quick availability of results. Intensified drug regimens using high dose rifampicin, fluoroquinolone an d aspirin appear to be useful...
Source: Indian Journal of Pediatrics - December 4, 2019 Category: Pediatrics Source Type: research

Dispersal of Mycobacterium tuberculosis Driven by Historical European Trade in the South Pacific
Mycobacterium tuberculosis (Mtb) is a globally distributed bacterial pathogen whose population structure has largely been shaped by the activities of its obligate human host. Oceania was the last major global region to be reached by Europeans and is the last region for which the dispersal and evolution of Mtb remains largely unexplored. Here, we investigated the evolutionary history of the Euro-American L4.4 sublineage and its dispersal to the South Pacific. Using a phylodynamics approach and a dataset of 236 global Mtb L4.4 genomes we have traced the origins and dispersal of L4.4 strains to New Zealand. These strains are ...
Source: Frontiers in Microbiology - December 4, 2019 Category: Microbiology Source Type: research

Treatment of multidrug-resistant tuberculosis using therapeutic drug monitoring: first experiences with sub-300 mg linezolid dosages using in-house made capsules
Despite all our efforts, the disease burden of tuberculosis (TB) is not falling fast enough to reach the 2030 milestone of the End TB strategy [1]. Multidrug-resistant tuberculosis (MDR-TB) remains a public health crisis, with low treatment success rates [1]. The repurposed drug linezolid has emerged as a core drug in MDR-TB treatment regimens [2, 3], despite its toxicity, e.g. anaemia, peripheral neuropathy and gastrointestinal disorders, optic neuritis, and thrombocytopenia [4, 5]. Currently, linezolid is used off-label, as part of Group A "Medicines to be prioritised" of the World Health Organization (WHO) MDR...
Source: European Respiratory Journal - December 4, 2019 Category: Respiratory Medicine Authors: Bolhuis, M. S., van der Werf, T. S., Kerstjens, H. A. M., de Lange, W. C. M., Alffenaar, J.-W. C., Akkerman, O. W. Tags: Original Articles: Research letters Source Type: research

Targeting Unconventional T Cells for Vaccination Against Tuberculosis.
PMID: 31801037 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory Cell and Molecular Biology)
Source: American Journal of Respiratory Cell and Molecular Biology - December 4, 2019 Category: Molecular Biology Authors: Wilkinson KA, Cerrone M Tags: Am J Respir Cell Mol Biol Source Type: research

Simple and sensitive method for analysis of 14 anti-tuberculosis drugs using LC/MS/MS in human plasma.
CONCLUSIONS: The method applied the sensitive and reproducible determination of 14 frequently-used anti-TB drugs, which already showed benefit for some TB patients. PMID: 31800129 [PubMed - as supplied by publisher] (Source: Rapid Communications in Mass Spectrometry : RCM)
Source: Rapid Communications in Mass Spectrometry : RCM - December 4, 2019 Category: Chemistry Authors: Lei Q, Zhao Y, Wang H, Zhou J, Lv X, Dang L, Zhu C Tags: Rapid Commun Mass Spectrom Source Type: research

Heightened systemic levels of anti-inflammatory cytokines in pulmonary tuberculosis and alterations following anti-tuberculosis treatment.
CONCLUSION: Therefore, our data demonstrate that PTB is associated with altered levels of Type 2, regulatory and other anti-inflammatory cytokines, some of which are altered followed chemotherapy. Our data also reveal that anti-inflammatory cytokines are not markers of disease severity or bacterial burden in PTB. Elevations in anti-inflammatory cytokines might help prevent the detrimental effects of pro-inflammatory responses in PTB. PMID: 31811994 [PubMed - as supplied by publisher] (Source: Cytokine)
Source: Cytokine - December 4, 2019 Category: Molecular Biology Authors: Moideen K, Kumar NP, Bethunaickan R, Banurekha VV, Nair D, Babu S Tags: Cytokine Source Type: research

Synthesis and anti-Mycobacterium tuberculosis activity of imide- β-carboline and carbomethoxy-β-carboline derivatives.
Synthesis and anti-Mycobacterium tuberculosis activity of imide-β-carboline and carbomethoxy-β-carboline derivatives. Eur J Med Chem. 2019 Dec 04;187:111935 Authors: Lopes-Ortiz MA, Panice MR, Borges de Melo E, Ataide Martins JP, Baldin VP, Agostinho Pires CT, Caleffi-Ferracioli KR, Dias Siqueira VL, Bertin de Lima Scodro R, Sarragiotto MH, Cardoso RF Abstract A series of methyl β-carboline carboxylates (2a-g) and of imide-β-carboline derivatives containing the phthalimide (4a-g), maleimide (5b, g) and succinimide (6b, e, g) moiety were synthesized, and evaluated for their activity...
Source: European Journal of Medicinal Chemistry - December 4, 2019 Category: Chemistry Authors: Lopes-Ortiz MA, Panice MR, Borges de Melo E, Ataide Martins JP, Baldin VP, Agostinho Pires CT, Caleffi-Ferracioli KR, Dias Siqueira VL, Bertin de Lima Scodro R, Sarragiotto MH, Cardoso RF Tags: Eur J Med Chem Source Type: research

Prevalence of active tuberculosis infection in transplant recipients: A systematic review and meta-analysis
ConclusionA high suspicion level for TB, the early diagnosis and the prompt initiation of therapy could increase the survival rates among SOT patients. Overall, renal and lung TRs appear to have a higher predisposition for acquiring TB than other type of recipients. Monitoring of the high-risk recipients, prompt diagnosis, and appropriate treatment are required to manage TB infection among TRs especially in endemic areas. (Source: Microbial Pathogenesis)
Source: Microbial Pathogenesis - December 3, 2019 Category: Infectious Diseases Source Type: research

In vitro bactericidal activity of 3-Cinnamoyl-4-hydroxy-6-methyl-2-pyrone (CHP) against drug-susceptible, resistant and tolerant isolates of Mycobacterium tuberculosis
ConclusionOur results show strong bactericidal potential of CHP against M.tuberculosis that warrant its immediate mechanistic, pharmacokinetic and pharmacodynamic studies.Graphical abstract (Source: Journal of Global Antimicrobial Resistance)
Source: Journal of Global Antimicrobial Resistance - December 3, 2019 Category: Infectious Diseases Source Type: research

Adherence to tuberculosis preventive therapy measured by urine metabolite testing among people with HIV
Conclusion: Adherence to isoniazid preventive therapy among patients with HIV in Brazil and South Africa is inadequate, is overestimated by self-report, and declines with time on treatment. Shorter regimens for TB preventive therapy may improve adherence and completion, but adherence support for all patients may be necessary. (Source: AIDS)
Source: AIDS - December 3, 2019 Category: Infectious Diseases Tags: CLINICAL SCIENCE Source Type: research

CD4+ cell count stratification to guide tuberculosis preventive therapy for people living with HIV
Conclusion: TB incidence was high among all patients who did not receive IPT, including those with CD4+ cell count more than 350 cells/μl and negative or unknown TST results. TB preventive therapy should be provided to all people living with HIV in medium burden settings, regardless of CD4+ cell count and TST status. (Source: AIDS)
Source: AIDS - December 3, 2019 Category: Infectious Diseases Tags: Epidemiology and Social Source Type: research

A retrospective review of tuberculosis exposure among health care workers in a tertiary hospital
ConclusionsThe study results will guide TB contact tracing protocols in health care institutions. (Source: American Journal of Infection Control)
Source: American Journal of Infection Control - December 3, 2019 Category: Infectious Diseases Source Type: research

Ascaris lumbricoides coinfection reduces tissue damage by decreasing IL-6 levels without altering clinical evolution of pulmonary tuberculosis or Th1/Th2/Th17 cytokine profile
CONCLUSIONS: The association with Ascaris lumbricoides did not influence the Th1, Th2, and Th17 type responses, or the proportions of T lymphocyte subpopulations. However, higher serum levels of IL-6 in tuberculosis patients may explain the pulmonary parenchymal damage. (Source: Revista da Sociedade Brasileira de Medicina Tropical)
Source: Revista da Sociedade Brasileira de Medicina Tropical - December 3, 2019 Category: Tropical Medicine Source Type: research

The role of active case finding in reducing patient incurred catastrophic costs for tuberculosis in Nepal
This study therefore aimed to compare costs incurred by TB patients diagnosed through ACF and passive case finding (PCF), and to determine the prevalence and intensity of patient-incurred catastrophic costs in Nepal.MethodsThe study was conducted in two districts of Nepal: Bardiya and Pyuthan (Province No. 5) between June and August 2018. One hundred patients were included in this study in a 1:1 ratio (PCF: ACF, 25 consecutive ACF and 25 consecutive PCF patients in each district). The WHO TB patient costing tool was applied to collect information from patients or a member of their family regarding indirect and direct medic...
Source: Infectious Diseases of Poverty - December 3, 2019 Category: Infectious Diseases Source Type: research

Failure to complete treatment for latent tuberculosis infection in Portugal, 2013 –2017: geographic-, sociodemographic-, and medical-associated factors
This study reinforces that shorter course treatment for LTBI might reduce FCT. (Source: European Journal of Clinical Microbiology and Infectious Diseases)
Source: European Journal of Clinical Microbiology and Infectious Diseases - December 3, 2019 Category: Microbiology Source Type: research

I awoke with a bloody nose: Pulmonary Tuberculosis
A 40-year-old Latino man presented to the emergency department (ED) after he awoke at 4 AM with blood oozing from his nose. He then began vomiting bright red blood with clots. In the 3 weeks prior, he had presented twice for varying complaints including hyperglycemia to 400 mg/dL, myalgias that impaired walking, and reports that he felt increasingly unwell with fevers, chills, night sweats, headaches, and progressively worsening productive cough. He denied melena, hematochezia, and jaundice. (Source: The American Journal of Medicine)
Source: The American Journal of Medicine - December 3, 2019 Category: General Medicine Authors: Julia Anderson, Claire L. Jansson-Knodell, David Crabb Tags: Diagnostic Dilemma Source Type: research

Cycloserine enantiomers are reversible inhibitors of human alanine:glyoxylate aminotransferase: implications for primary hyperoxaluria type 1.
CYCLOSERINE ENANTIOMERS ARE REVERSIBLE INHIBITORS OF HUMAN ALANINE:GLYOXYLATE AMINOTRANSFERASE: IMPLICATIONS FOR PRIMARY HYPEROXALURIA TYPE 1. Biochem J. 2019 Dec 03;: Authors: Dindo M, Grottelli S, Annunziato G, Giardina G, Pieroni M, Pampalone G, Faccini A, Cutruzzolà F, Laurino P, Costantino G, Cellini B Abstract Peroxisomal alanine:glyoxylate aminotransferase (AGT) is responsible for glyoxylate detoxification in human liver and utilizes pyridoxal 5'-phosphate (PLP) as coenzyme. The deficit of AGT leads to Primary Hyperoxaluria Type I (PH1), a rare disease characterized by calcium oxalate st...
Source: The Biochemical Journal - December 3, 2019 Category: Biochemistry Authors: Dindo M, Grottelli S, Annunziato G, Giardina G, Pieroni M, Pampalone G, Faccini A, Cutruzzolà F, Laurino P, Costantino G, Cellini B Tags: Biochem J Source Type: research

Diagnostic Accuracy of Interleukin-27 in Bronchoalveolar Lavage Fluids for Pulmonary Tuberculosis
(Source: Infection and Drug Resistance)
Source: Infection and Drug Resistance - December 2, 2019 Category: Infectious Diseases Tags: Infection and Drug Resistance Source Type: research

Treatment outcomes and their trend among tuberculosis patients treated at peripheral health settings of Northern Ethiopia between 2009 and 2014: a registry-based retrospective analysis
This study was aimed a... (Source: BMC Research Notes)
Source: BMC Research Notes - December 2, 2019 Category: Research Authors: Mahmud Abdulkader, Ischa van Aken, Selam Niguse, Haftamu Hailekiros and Mark Spigt Tags: Research note Source Type: research

Masqueraders of multiple evanescent white dot syndrome (MEWDS)
ConclusionsWidespread grayish-white outer retinal spots associated with hyperautofluorescence on FAF and disruption of the EZ on OCT are not pathognomonic for MEWDS. A high index of suspicion must be maintained for masqueraders of MEWDS, which can include serious inflammatory, infectious, and neoplastic disorders. (Source: International Ophthalmology)
Source: International Ophthalmology - December 2, 2019 Category: Opthalmology Source Type: research

In vitro Susceptibility Testing of GSK656 against mycobacteria species.
In conclusion, our data demonstrate that GSK656 exhibits significant species diversity in in vitro susceptibility against various mycobacteria species. GSK656 has potent efficacy against MTB and M. abscessus, whereas the inherent resistance is noted in M. intracellulare and M. avium. PMID: 31791947 [PubMed - as supplied by publisher] (Source: Antimicrobial Agents and Chemotherapy)
Source: Antimicrobial Agents and Chemotherapy - December 2, 2019 Category: Microbiology Authors: Dong W, Li S, Wen S, Jing W, Shi J, Ma Y, Huo F, Gao F, Pang Y, Lu J Tags: Antimicrob Agents Chemother Source Type: research

Polyclonal infection as a new scenario in Mycobacterium caprae epidemiology
Publication date: Available online 30 November 2019Source: Veterinary MicrobiologyAuthor(s): Ana C. Reis, Teresa Albuquerque, Ana Botelho, Mónica V. CunhaAbstractPortugal is one of the European Union countries with an ongoing eradication program for bovine tuberculosis (TB), which does not include systematic goat testing. However, surveillance in small ruminants is increasingly important, since goat and sheep can harbour Mycobacterium caprae and be an infection source to cattle with impact in the success of bovine TB control. Furthermore, the information regarding the epidemiology and biology of M. caprae is quite l...
Source: Veterinary Microbiology - December 1, 2019 Category: Veterinary Research Source Type: research

Biomarkers of Cell-Mediated Immunity to Bovine Tuberculosis
Publication date: Available online 30 November 2019Source: Veterinary Immunology and ImmunopathologyAuthor(s): Mitchell V. Palmer, Tyler C. Thacker, Meaghan M. Rabideau, Gareth J. Jones, Carly Kanipe, H. Martin Vordermeier, W. Ray WatersAbstractWhole blood based assays, particularly interferon gamma (IFN-γ) release assays (IGRAs), are used for the diagnosis of both bovine and human tuberculosis (TB). The aim of the current study was to evaluate a panel of cytokines and chemokines for potential use as diagnostic readouts indicative of Mycobacterium bovis (M. bovis) infection in cattle. A gene expression assay was used...
Source: Veterinary Immunology and Immunopathology - December 1, 2019 Category: Veterinary Research Source Type: research

QuantiFERON-TB Gold Test Conversion Is Associated with Active Tuberculosis Development in Inflammatory Bowel Disease Patients Treated with Biological Agents: An Experience of a Medical Center in Taiwan.
Authors: Lai HC, Chang CH, Cheng KS, Chen TW, Tsai YY, Chou JW Abstract Taiwan has a lower prevalence of inflammatory bowel disease (IBD) and a higher prevalence of tuberculosis (TB) infection than Western countries. The aim of this study was to investigate the prevalence of latent TB (LTB) and active TB infection in IBD patients treated with biological agents. From January 2000 to September 2018, we retrospectively collected data from IBD patients treated with biological agents at a tertiary referral center. Patients underwent a QuantiFERON-TB Gold test (QFT) to screen for TB infection before and after biological ...
Source: Gastroenterology Research and Practice - December 1, 2019 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Diabetes Mellitus among Adult Tuberculosis Patients Attending Tuberculosis Clinics in Eastern Ethiopia.
Conclusion: This study found that the magnitude of diabetes mellitus among tuberculosis patients was higher than the national estimated prevalence of diabetes mellitus in Ethiopia. This study suggests the need for screening each tuberculosis patient for diabetes. PMID: 31781641 [PubMed - in process] (Source: Biomed Res)
Source: Biomed Res - December 1, 2019 Category: Research Authors: Tenaye L, Mengiste B, Baraki N, Mulu E Tags: Biomed Res Int Source Type: research

Reactive arthritis induced by active extra-articular tuberculosis: A case report
We report the case of successfully treated a patient with reactive arthritis induced by active extra-articular tuberculosis with a TNF inhibitor after sufficient antitubercular treatment. Patient concerns: A 56-year-old Japanese man was admitted to our department with polyarthralgia, low back pain, and high fever. The results of rheumatoid factor, anti-citrullinated protein antibody, human leukocyte antigen B27, and the assays for the detection of infections (with an exception of T-SPOT.TB) were all negative. Fluoro-deoxy-D-glucose–positron emission tomography with CT (PET/CT) showed moderate uptake in the right c...
Source: Medicine - December 1, 2019 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research

Polymorphism of MPT64 and PstS1 in Mycobacterium tuberculosis is not likely to affect relative immune reaction in human
Conclusion: MPT64 and PstS1 are likely candidate diagnostic antigens for M tuberculosis T-spot test, at least in combination with other proteins. Polymorphisms of MPT64 and PstS1 had little effect on cell-mediated and humoral immunity in the host. (Source: Medicine)
Source: Medicine - December 1, 2019 Category: Internal Medicine Tags: Research Article: Clinical Trial/Experimental Study Source Type: research

Co-existence of well-differentiated fetal adenocarcinoma of the lung with tuberculosis in a young female: A rare case report
Rationale: Fetal adenocarcinoma of the lung (FLAC) with fetal lung-like morphology is a rare entity of pulmonary adenocarcinoma. Well-differentiated fetal adenocarcinoma (WDFA) belongs to its the low-grade form, which possesses a relatively favorable prognosis. Tuberculosis (TB) is an aggressive infectious disease that has been ranked as one of the top 10 causes of death worldwide. There may be a connection between the 2 and attention should be paid to the differential diagnosis. Patient concerns: A 28-year-old non-smoking female was admitted with signs of hemoptysis, and she had been coughing up phlegm for 5 years. T...
Source: Medicine - December 1, 2019 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research

Multidrug resistant lymph node fistula tracheobronchial tuberculosis: A case report
Rationale: The patient in this case report has been diagnosed with multidrug resistant lymph node fistula tracheobronchial tuberculosis (TBTB). The PubMed was searched using the keywords “Tuberculosis, Multidrug-Resistant”, “Tuberculosis”, and “Bronchial Fistula”, and the results yielded no similar case reports. Therefore, this report helps us to explore more on the causes of multidrug resistance and formation of lymph node fistula, as well as associated treatment strategies. Patient concerns: A 15-year old Tibetan girl who was previously treated in the local Hospital for Infectious...
Source: Medicine - December 1, 2019 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research

Serum proteome profiles to differentiate Crohn disease from intestinal tuberculosis and primary intestinal lymphoma: A pilot study
The differential diagnosis of Crohn disease (CD) from intestinal tuberculosis (ITB) and primary intestinal lymphoma (PIL) is challenging in patients who exhibit atypical clinical characteristics. The aim of the present study was to explore the serum proteome profiles of CD, PIL and ITB and to identify their differentiations. Treatment-naïve patients with CD (n = 10), PIL (n = 10) and ITB (n = 10) were enrolled in the present study. Differentially expressed proteins (DEPs) in patient serum samples were compared between groups using tandem mass tag labeled proteomic technology. A principal component analysi...
Source: Medicine - December 1, 2019 Category: Internal Medicine Tags: Research Article: Diagnostic Accuracy Study Source Type: research

Mycobacterium tuberculosis and Pseudoramibacter alactolyticus coinfection in brain after dental extraction: A case report
Conclusion: In conclusion there should be awareness of the possibility of P alactolyticus or MTB intracranial infections following tooth extraction. (Source: Medicine)
Source: Medicine - December 1, 2019 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research

A case report on the effect of rituximab on pyothorax-associated lymphoma
We report a case of a patient, whose tuberculosis and lymphoma were diagnosed concurrently. Patient concerns: The patient, a 76-year-old male, was reported to our hospital on March 13, 2015. He had recurrent shortness of breath during the previous 2 years of routine activities solely. His symptoms became more serious which was manifested by edema of lower limbs 1 day before his admission to our hospital. Diagnoses: Doctors reached the diagnosis of PAL based on the patient's pathologic cell morphology and immunohistochemistry. The chest computed tomography examination revealed that there were pleural effusions on both...
Source: Medicine - December 1, 2019 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research

Reactivation of latent tuberculosis infection induced by cabazitaxel in a patient with prostate cancer: A case report
Rationale: Latent tuberculosis infection (LTBI) describes the dormant state of tuberculosis (TB), in which persistent immune-related interaction between TB and T-cells maintain its state. Cabazitaxel (CBZ) is reported to improve overall survival in patients with castration-resistant prostate cancer (CRPC) after progression observed in regimens including docetaxel. CBZ is known for severe myelosuppression; however there is no recommendation for the treatment of LTBI before CBZ treatment. To the authors’ knowledge, this is the first report to describe reactivation of LTBI induced by CBZ. Patient concerns: A 75-yea...
Source: Medicine - December 1, 2019 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research