[Indications and perioperative results of completion pneumonectomy].
Conclusions: Morbidity and mortality are the highest after rCP, but these patients usually do not have any other chance for healing. We have not performed repeat surgery for incomplete tumour resection in the last 10 years. Comparing our results to the international data, the morbidity after cCP is high, the mortality is similar. PMID: 31813241 [PubMed - in process] (Source: Magyar Sebeszet)
Source: Magyar Sebeszet - December 1, 2019 Category: Surgery Authors: Kas J, Csekeő A, Fehér C, Karskó L, Kecskés L, Molnár M, Vágvölgyi A, Varga JT, Bede A, Rozgonyi Z, Fillinger J, Soltész I, Elek J, Agócs L, Rényi-Vámos F, Kocsis Á Tags: Magy Seb Source Type: research

Belarus and drug-resistant tuberculosis.
Authors: Abstract A comprehensive approach to delivering patient-centred treatment underpins Belarus's progress against drug resistant tuberculosis. Andrey Shukshin and Gary Humphreys report. PMID: 31819286 [PubMed - in process] (Source: Bulletin of the World Health Organization)
Source: Bulletin of the World Health Organization - December 1, 2019 Category: International Medicine & Public Health Tags: Bull World Health Organ Source Type: research

[Disseminated tuberculosis mimicking metastatic gastric cancer - a  case report].
We report the case of a 77-year-old male patient who presented with unilateral leg pain and B symptoms. Further investigations revealed an osteolytic mass in the sacrum as well as CT-morphological findings consistent with metastatic gastric cancer. However, transgastric biopsies showed necrotising granuloma with giant cells leading to molecular and cultural detection of Mycobacterium tuberculosis instead of suspected neoplastic tissue. A nine-month treatment regimen for suspected disseminated tuberculosis with bone involvement was initiated according to national guidelines. Clinical and radiological follow up examinations ...
Source: Zeitschrift fur Gastroenterologie - December 1, 2019 Category: Gastroenterology Authors: Voit FM, Abdelhafez M, Rothe K, Slotta-Huspenina J, Gaa J, Schmid RM, Spinner CD Tags: Z Gastroenterol Source Type: research

Performance of Xpert MTB/RIF Ultra and Xpert MTB/RIF for the Diagnosis of Tuberculosis through Testing of Formalin-fixed Paraffin-embedded Tissues.
PMID: 31918797 [PubMed - in process] (Source: Biomedical and Environmental Sciences : BES)
Source: Biomedical and Environmental Sciences : BES - December 1, 2019 Category: Biomedical Science Authors: DU WL, Song J, Wang JG, Liu ZC, Li K, Wang YX, Dong YJ, Che NY Tags: Biomed Environ Sci Source Type: research

Immune reconstitution inflammatory syndrome in the lung in non-human immunodeficiency virus patients
ConclusionsThe diagnosis and management of IRIS in the lung in non-HIV patients should be investigated further, especially in the era of anti-TNF treatment. (Source: Respiratory Investigation)
Source: Respiratory Investigation - November 30, 2019 Category: Respiratory Medicine Source Type: research

Differed IL-1 Beta Response between Active TB and LTBI Cases by Ex Vivo Stimulation of Human Monocyte-Derived Macrophage with TB-Specific Antigen.
Conclusions: This study revealed that macrophage-specific IL-1b response differed among different stages of Mycobacterium tuberculosis infection. The role of IL-1b and inflammasome in the process of LTBI progressing to active TB warrants further investigation. PMID: 31781307 [PubMed - in process] (Source: Disease Markers)
Source: Disease Markers - November 30, 2019 Category: Laboratory Medicine Tags: Dis Markers Source Type: research

Simultaneous Determination of Isoniazid, Pyrazinamide and Rifampin in Human Plasma by ...
The objective of the study was to develop and optimize a simple, sensitive, and reliable high-performance liquid chromatography (HPLC) method for the simultaneous determination of isoniazid (INH), pyrazinamide (PZA), and rifampin (RIF) levels in human plasma. Nicotinamide was used as the internal standard and the samples were prepared after protein precipitation using acetonitrile and zinc sulfate. The separation was achieved using a C18 reversed-phase applying gradient elution. The mobile phase was a combination of water–methanol solution with a ratio of 95:05 (v/v) at the initial phase. All calibration curves had g...
Source: Iranian Journal of Pharmaceutical Research - November 30, 2019 Category: Drugs & Pharmacology Source Type: research

Development of 1,2,4-triazole-5-thione derivatives as potential inhibitors of enoyl acyl ...
Tuberculosis (TB) ranks second, next to AIDS making it most formidable disease if the present age. One of the crucial enzymes involved in cell wall synthesis of Mycobacterium tuberculosis, InhA (enoyl acyl carrier protein reductase) has been authenticated as an effective target for anti-mycobacterial drug development. In the current work, we have developed novel derivatives of 1,2,4-triazole-5-thione as promising InhA inhibitors. We rationally designed these 1,2,4-triazole-5-thione compounds, synthesized and spectrally characterized them. Anti-mycobacterial potential was determined by resazurin microtiter assay using Mtb H...
Source: Iranian Journal of Pharmaceutical Research - November 30, 2019 Category: Drugs & Pharmacology Source Type: research

Candida coinfection among patients with pulmonary tuberculosis in Asia and Africa; A systematic review and meta-analysis of cross-sectional studies
Publication date: Available online 30 November 2019Source: Microbial PathogenesisAuthor(s): Mehdi Hadadi‐Fishani, Ali Shakerimoghaddam, Azad KhalediAbstractDiagnosis of fungal co-infections in patients suffering from pulmonary tuberculosis has critical importance. Therefore, we aimed to determine the prevalence of candida coinfection in patients with pulmonary tuberculosis.The present systematic review of cross-sectional studies was conducted based on the Preferred Reporting Items for Systematic reviews and Meta-analysis (PRISMA) Protocol. Studies published online in English from January 2001 to March 2019 were assessed....
Source: Microbial Pathogenesis - November 30, 2019 Category: Infectious Diseases Source Type: research

Tuberculosis in prison and aspects associated with the diagnosis site
Conclusions: The results show that intricate TB cases were notified by the local health services. Strategies of surveillance and articulation with these health services seem to contribute to the identification of TB cases among PDL. (Source: The Journal of Infection in Developing Countries)
Source: The Journal of Infection in Developing Countries - November 30, 2019 Category: Infectious Diseases Source Type: research

Heterologous prime-boost vaccination against tuberculosis with recombinant Sendai virus and DNA vaccines
In this study, we evaluate whether the immune responses induced by this novel vaccine might be elevated by a recombinant DNA vaccine expressing the same antigen in a heterologous prime-boost vaccination strategy. The results showed that both SeV85AB prime-DNA boost (SeV85AB-DNA) and DNA prime-SeV85AB boost (DNA-SeV85AB) vaccination strategies significantly enhanced the antigen-specific T cell responses induced by the separate vaccines. The SeV85AB-DNA immunization regimen induced higher levels of recall T cell responses afterMtb infection and conferred better immune protection compared with DNA-SeV85AB or a single immuniza...
Source: Journal of Molecular Medicine - November 30, 2019 Category: Molecular Biology Source Type: research

Impacts of metformin on tuberculosis incidence and clinical outcomes in patients with diabetes: a systematic review and meta-analysis
ConclusionsThis meta-analysis indicated metformin use is related to benefits in both prevention and treatment outcomes of tuberculosis among patients with diabetes. Prospective clinical trials are needed to confirm these associations. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - November 30, 2019 Category: Drugs & Pharmacology Source Type: research

Miliary tuberculosis and choroidal tuberculoma in a three-month old baby girl: Diagnosis and follow-up of a case.
Authors: Macías-Franco S, Fernández-García M, Costales-Álvarez C, Mayordomo-Colunga J, Rozas-Reyes P Abstract A three-month old baby girl presented with fever of unknown origin and with signs of worsening of this episode. Funduscopy showed a solitary choroidal lesion in her left eye, as well as extraocular lesions suggesting disseminated tuberculosis. A favourable outcome was achieved after quadruple antibiotic course and cortisone therapy. Disseminated tuberculosis should be considered in cases of fever of unknown origin in children with an unsatisfactory evolution. Ocular examination i...
Source: Archivos de la Sociedad Espanola de Oftalmologia - November 29, 2019 Category: Opthalmology Tags: Arch Soc Esp Oftalmol Source Type: research

Pakistan's Health and Population Think Tank: a policy platform for achieving Sustainable Development Goal 3 national targets.
Authors: Shaikh BT, Hafeez A, Ali N Abstract In Pakistan, the Health and Population Think Tank was launched as an initiative to conduct programmes and policy analysis, as well as give an insight into the possible future policy options on various national health issues relevant to all the provinces. This forum has also served as a platform to discuss how provincial strategies could be aligned with the National Health Vision 2016-2025, which was developed with the consensus of all provinces and development partners. Main topics chosen for the round tables included local production of vaccines; social health protectio...
Source: Eastern Mediterranean Health Journal - November 29, 2019 Category: Middle East Health Tags: East Mediterr Health J Source Type: research

Fissurectomy with posterior midline internal sphincterotomy and anoplasty in the management of chronic posterior anal fissures
ConclusionFissurectomy with posterior midline internal sphincterotomy and mucosal anoplasty is safe with minimal complications. It is still a dependable alternative treatment for chronic posterior anal fissures. The fear of keyhole deformity can be well addressed with the added anoplasty. (Source: Current Medicine Research and Practice)
Source: Current Medicine Research and Practice - November 29, 2019 Category: General Medicine Source Type: research

Elucidation of drug resistance mutations in Mycobacterium tuberculosis isolates from North India by whole-genome sequencing
ConclusionWGS ofM. tuberculosis isolates allows the detection of drug resistance to all drugs in a single test and also provides insight into the evolution and drug-resistant TB. (Source: Journal of Global Antimicrobial Resistance)
Source: Journal of Global Antimicrobial Resistance - November 29, 2019 Category: Infectious Diseases Source Type: research

Genexpert for abdominal tuberculosis
CONCLUSION: NRS was more sensitive than other indicators in the diagnosis of malnutrition. Patients at risk were older and had lower HEC values, calf circumference, BMI and lymphocyte count. Low lymphocyte count was considered a factor associated with nutritional risk by the NRS.RESUMO CONTEXTO: A desnutri ção está associada a fatores clínicos, incluindo maior tempo de internação, aumento da morbimortalidade e custos hospitalares. OBJETIVO: Investigar a prevalência de desnutrição por diferentes indicadores nutricionais e identificar fatores que contribuem para a...
Source: Arquivos de Gastroenterologia - November 29, 2019 Category: Gastroenterology Source Type: research

Use of Ultra-Deep Sequencing in a Patient with Tuberculous Coxitis Shows Its Limitations in Extrapulmonary Tuberculosis Diagnostics: A Case Report
(Source: Infection and Drug Resistance)
Source: Infection and Drug Resistance - November 29, 2019 Category: Infectious Diseases Tags: Infection and Drug Resistance Source Type: research

Economic analyses to inform public health decision-making for tuberculosis: the role of understanding implementation
(Source: BMC Medicine)
Source: BMC Medicine - November 29, 2019 Category: Internal Medicine Authors: Priya B. Shete and James G. Kahn Tags: Commentary Source Type: research

Tuberculosis infectious pool and associated factors in East Gojjam Zone, Northwest Ethiopia
Globally, tuberculosis (TB) lasts a major public health concern. Using feasible strategies to estimate TB infectious periods is crucial. The aim of this study was to determine the magnitude of TB infectious pe... (Source: BMC Pulmonary Medicine)
Source: BMC Pulmonary Medicine - November 29, 2019 Category: Respiratory Medicine Authors: Mulusew Andualem Asemahagn, Getu Degu Alene and Solomon Abebe Yimer Tags: Research article Source Type: research

Molecules, Vol. 24, Pages 4373: A Repurposing Approach for Uncovering the Anti-Tubercular Activity of FDA-Approved Drugs with Potential Multi-Targeting Profiles
Sandra Gemma Tuberculosis (TB) is one of the top 10 causes of death worldwide. This scenario is further complicated by the insurgence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) TB. The identification of appropriate drugs with multi-target affinity profiles is considered to be a widely accepted strategy to overcome the rapid development of resistance. The aim of this study was to discover Food and Drug Administration (FDA)-approved drugs possessing antimycobacterial activity, potentially coupled to an effective multi-target profile. An integrated screening platform was implemented based on comput...
Source: Molecules - November 29, 2019 Category: Chemistry Authors: Basem Battah Giulia Chemi Stefania Butini Giuseppe Campiani Simone Brogi Giovanni Delogu Sandra Gemma Tags: Article Source Type: research

BCG-Induced Cross-Protection and Development of Trained Immunity: Implication for Vaccine Design
The Bacillus Calmette-Guérin (BCG) is a live attenuated tuberculosis vaccine that has the ability to induce non-specific cross-protection against pathogens that might be unrelated to the target disease. Vaccination with BCG reduces mortality in newborns and induces an improved innate immune response against microorganisms other than Mycobacterium tuberculosis, such as Candida albicans and Staphylococcus aureus. Innate immune cells, including monocytes and natural killer (NK) cells, contribute to this non-specific immune protection in a way that is independent of memory T or B cells. This phenomenon associated with a...
Source: Frontiers in Immunology - November 29, 2019 Category: Allergy & Immunology Source Type: research

Predictors of Linkage to Care for a Nontargeted Emergency Department Hepatitis C Screening Program
Hepatitis C (HCV) is the most common chronic blood-borne illness in the United States, estimated to affect 2.7 to 3.9 million persons [1,2]. A leading cause of end stage liver disease, hepatocellular carcinoma, and liver transplantation [2 –4], HCV is now responsible for more deaths annually in the U.S. than HIV, tuberculosis, and 58 other nationally reportable infectious diseases combined [5]. As an estimated three quarters of HCV-infected individuals in the U.S. were born between 1945 and 1965, the Centers for Disease Control and Prevention (CDC) and United States Preventive Services Task Force (USPSTF) issued reco...
Source: The American Journal of Emergency Medicine - November 29, 2019 Category: Emergency Medicine Authors: Joshua A. Blackwell, Joel B. Rodgers, Ricardo A. Franco, Stacey S. Cofield, Lauren A. Walter, James W. Galbraith, Erik P. Hess Source Type: research

Leukoplakia or LPR: The Misdiagnosis of Laryngeal Tuberculosis.
CONCLUSIONS: Laryngeal tuberculosis was easily misdiagnosed as acute epiglottitis or leukoplakia because of diffuse swelling of the epiglottis or white lesions over the true vocal cord, especially patients with increasing LTB were misdiagnosed as LPR with the enhancement of LPR awareness among otolaryngologist. Clinicians should be aware of the possibility of LTB for chronic intractable laryngitis with failure treatment of proton pump inhibitor and recurrent acute epiglottitis with foreign body injury. PMID: 31779475 [PubMed - as supplied by publisher] (Source: Ear, Nose and Throat Journal)
Source: Ear, Nose and Throat Journal - November 29, 2019 Category: ENT & OMF Authors: Lou ZC, Li X Tags: Ear Nose Throat J Source Type: research

Chromone and isocoumarin derivatives from the endophytic fungus Xylomelasma sp. Samif07, and their antibacterial and antioxidant activities.
Abstract Five chromone derivatives, including 2,6-dimethyl-5-methoxyl-7-hydroxylchromone (1), 6-hydroxymethyleugenin (2), 6-methoxymethyleugenin (3), chaetoquadrin D (4), and isoeugenitol (5), and three isocoumarin congeners, namely diaporthin (6), 8-hydroxy-6-methoxy-3-methylisocoumarin (7), and 6-methoxymellein (8), were isolated from the culture of the endophytic fungus Xylomelasma sp. Samif07 derived from the medicinal plant Salvia miltiorrhiza Bunge. Among them, compound 1 was a new natural product. Their structures were determined by spectroscopic methods and comparison with the literature. The isolated comp...
Source: Natural Product Research - November 29, 2019 Category: Biochemistry Authors: Lai D, Li J, Zhao S, Gu G, Gong X, Proksch P, Zhou L Tags: Nat Prod Res Source Type: research

Characteristics and outcomes of pediatric tuberculous meningitis patients with complicated by hydrocephalus with or without tuberculoma at Regional Public Hospital Teluk Bintuni, West Papua, Indonesia
ConclusionsIn conclusion, majority of TBM pediatric patients in RSUD Teluk Bintuni develop hydrocephalus and tuberculoma. The present of hydrocephalus and tuberculoma in these cases showed the severity of their conditions in which resulted in poor outcome. The capability for early diagnosis, or even prevention aspect in Regional Public Hospital Teluk Bintuni pediatric TBM patient is a very important factors that might affect the outcomes. (Source: Interdisciplinary Neurosurgery)
Source: Interdisciplinary Neurosurgery - November 28, 2019 Category: Neurosurgery Source Type: research

Tween 80 induces a carbon flux rerouting in Mycobacterium tuberculosis
This study is the first to identify specific metabolome variations related to the addition of Tween 80 to the growth media during M. tuberculosis culturing. The consideration of these results during the method development and data interpretation phases of future metabolomics investigations will improve the quality of the analyses as well as the credibility of potential research outcomes. These results will also assist in the interpretation of research questions specifically aimed at aspects of mycobacterial metabolism, even when using other methodologies such as transcriptomics or fluxomics. (Source: Journal of Microbiological Methods)
Source: Journal of Microbiological Methods - November 28, 2019 Category: Microbiology Source Type: research

The association between vitamin D status and infectious diseases of the respiratory system in infancy and childhood.
CONCLUSIONS: Most studies agree in that decreased vitamin D concentrations are prevalent among most infants and children with RTIs. Also, normal to high-serum 25(OH)D appears to have some beneficial influence on the incidence and severity of some, but not all, types of these infections. However, studies with vitamin D supplementation revealed conflicting results as to whether supplementation may be of benefit, and at what doses. PMID: 31768940 [PubMed - as supplied by publisher] (Source: Hormones)
Source: Hormones - November 28, 2019 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

Minority Mycobacterium tuberculosis Genotypic Populations as an Indicator of Subsequent Phenotypic Resistance.
PMID: 31774334 [PubMed - in process] (Source: Am J Respir Cell Mol...)
Source: Am J Respir Cell Mol... - November 28, 2019 Category: Respiratory Medicine Authors: Engelthaler DM, Streicher EM, Kelley EJ, Allender CJ, Wiggins K, Jimenez D, Lemmer D, Vittinghoff E, Theron G, Sirgel FA, Warren RM, Metcalfe JZ Tags: Am J Respir Cell Mol Biol Source Type: research

Vertebral Column Resection for Post Tuberculosis Severe Kyphotic deformity: Results of 5 year follow-up
This study was undertaken to evaluate the results, efficacy and safety of this technique.MethodsDeformity correction of 16 patients was done during January 2012 to December 2014. All patients underwent posterior only approach for vertebral column resection at peri-apical region, posterior instrumentation with pedicular screws and anterior reconstruction using mesh cage. Postoperative X-ray films were evaluated. All patients were followed up at six weeks, 12 weeks, 18 weeks, six months and yearly thereafter. At follow-up patients were evaluated neurologically and radio-graphically.ResultsMean age of the patients was 19.43 y...
Source: Journal of Orthopaedics - November 28, 2019 Category: Orthopaedics Source Type: research

Lung adenocarcinoma presumed to be Pott's disease in a 28-year-old patient: A case report and review of literature.
Conclusion: In this case report, a 28-year-old male was treated for thoracic Pott's disease that proved to be metastatic lung adenocarcinoma. To avoid such misdiagnoses in the future, physicians should better differentiate spinal TB from other malignancies that may affect the spine. This study underscores the importance of obtaining at least a chest X-ray in any patient with suspected Pott's disease, irrespective of age, to help rule out lung cancer or other pathologies. PMID: 31768288 [PubMed] (Source: Surgical Neurology International)
Source: Surgical Neurology International - November 28, 2019 Category: Neurosurgery Tags: Surg Neurol Int Source Type: research

Modified BCG vaccine could prevent TB in cattle and help end culls
A modified version of the BCG vaccine against tuberculosis could allow cattle around the world to be vaccinated against the disease (Source: New Scientist - Health)
Source: New Scientist - Health - November 28, 2019 Category: Consumer Health News Source Type: research

Differential expression and predictive value of monocyte scavenger receptor CD163 in populations with different tuberculosis infection statuses
Monocytes are the predominant innate immune cells at the early stage of Mycobacterium tuberculosis (M. tb) infection as the host defense against intracellular pathogens. Understanding the profile of different mon... (Source: BMC Infectious Diseases)
Source: BMC Infectious Diseases - November 28, 2019 Category: Infectious Diseases Authors: Qianqian Liu, Qinfang Ou, Huaxin Chen, Yan Gao, Yuanyuan Liu, Yuzhen Xu, Qiaoling Ruan, Wenhong Zhang and Lingyun Shao Tags: Research article Source Type: research

Latent tuberculosis screening and treatment among asylum seekers: a mixed-methods study
Conclusion LTBI screening and treatment of asylum seekers is feasible and effective when high quality of care is provided, including culture-sensitive TB education throughout the care cascade. Additionally, collaboration with partner organisations, such as agencies responsible for reception and support of asylum seekers, should be in place. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 28, 2019 Category: Respiratory Medicine Authors: Spruijt, I., Tesfay Haile, D., Suurmond, J., van den Hof, S., Koenders, M., Kouw, P., van Noort, N., Toumanian, S., Cobelens, F., Goosen, S., Erkens, C. Tags: Respiratory infections and tuberculosis Original Articles: Tuberculosis Source Type: research

Accuracy of whole-genome sequencing to determine recent tuberculosis transmission: an 11-year population-based study in Hamburg, Germany
Controlling human-to-human tuberculosis (TB) transmission is key for achieving the targets of the End TB Strategy set by the World Health Organization (WHO) [1, 2]. Stopping TB transmission, in large cities especially, is a challenging top priority worldwide [3]. Metropolitan areas have higher TB case notification rates than the rest of a country, as they concentrate high-risk groups, such as homeless people, drug users and migrants often from (other) high TB incidence settings. Opportunities for transmission are amplified by population density and complex social interactions, regularly leading to large, temporally extende...
Source: European Respiratory Journal - November 28, 2019 Category: Respiratory Medicine Authors: Diel, R., Kohl, T. A., Maurer, F. P., Merker, M., Meywald Walter, K., Hannemann, J., Nienhaus, A., Supply, P., Niemann, S. Tags: Original Articles: Research letters Source Type: research

Detection of Mutations in Mycobacterium tuberculosis pncA Gene by Modified High-Resolution Melting Curve Analysis of PCR Products
We developed a protocol for detection of mutations in thepncA gene associated withM. tuberculosis resistance to pyrazinamide by analyzing melting curves of 7 overlapping amplicons with artificial heteroduplex formation (H-HRM) formed by co-amplification of wild-type DNA and test DNA and compared its efficiency and robustness with those of classical HRM analysis. Using HRM and H-HRM, we analyzed 35 PZAR DNA isolates carrying mutations in thepncA gene, 3 PZAR isolates without mutations in thepncA gene, and 20 PZAS isolates without mutations in thepncA gene were analyzed. The sensitivity and specificity of HRM for detection o...
Source: Bulletin of Experimental Biology and Medicine - November 28, 2019 Category: Biology Source Type: research

Radio-biologically motivated modeling of radiation risks of mortality from ischemic heart diseases in the Canadian fluoroscopy cohort study.
tska LB Abstract Recent analyses of the Canadian fluoroscopy cohort study reported significantly increased radiation risks of mortality from ischemic heart diseases (IHD) with a linear dose-response adjusted for dose fractionation. This cohort includes 63,707 tuberculosis patients from Canada who were exposed to low-to-moderate dose fractionated X-rays in 1930s-1950s and were followed-up for death from non-cancer causes during 1950-1987. In the current analysis, we scrutinized the assumption of linearity by analyzing a series of radio-biologically motivated nonlinear dose-response models to get a better understand...
Source: Radiation and Environmental Biophysics - November 28, 2019 Category: Physics Authors: Schöllnberger H, Kaiser JC, Eidemüller M, Zablotska LB Tags: Radiat Environ Biophys Source Type: research

Longitudinal dynamics of herd-level Mycobacterium bovis MLVA type surveillance in cattle in Northern Ireland 2003-2016.
Abstract Investigating genetically-structured diversity in pathogen populations over time is important to better understand disease maintenance and spread. Herd-level surveillance of Mycobacterium bovis genotypes (multi-locus VNTR analysis types, MLVA types) from all culture-confirmed bovine tuberculosis (TB) herd cases was undertaken in Northern Ireland (NI), generating an unparalleled, longitudinal, population-level 14-year survey for this pathogen. Across this population, 295 genetically-distinct M. bovis MLVA types were identified in the 19,717 M. bovis isolates surveyed. Of these, the most frequent was MLVA...
Source: Infection, Genetics and Evolution - November 28, 2019 Category: Genetics & Stem Cells Authors: Skuce R, Breadon E, Allen A, Milne G, McCormick C, Hughes C, Rutherford D, Smith G, Thompson S, Graham J, Harwood R, Byrne A Tags: Infect Genet Evol Source Type: research

Tubercular Uveitis: Nuggets from Collaborative Ocular Tuberculosis Study (COTS)-1.
Conclusion: The current review aims to focus on methodology and briefing of published reports from COTS group in COTS-1 study to highlight key messages from this large data. PMID: 31763952 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)
Source: Ocular Immunology and Inflammation - November 27, 2019 Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research

Vitamin D Status in Children with Tuberculosis
(Source: Indian Journal of Pediatrics)
Source: Indian Journal of Pediatrics - November 27, 2019 Category: Pediatrics Source Type: research

Development of Disseminated Tuberculosis with Intestinal Involvement due to Adalimumab Administration Despite Latent Tuberculosis Treatment.
Authors: Ikuta K, Ota Y, Kuroki S, Matsumoto Y, Senda E, Mukohara S, Takahashi S, Monden K, Fukuda A, Seno H, Kumagai S, Shio S Abstract Treatment of latent tuberculosis infection (LTBI) reduces the probability of reactivation of tuberculosis associated with anti-TNFα inhibitors, but no chemoprophylaxis is completely protective. We herein report a woman with rheumatoid arthritis who developed disseminated tuberculosis with intestinal involvement during adalimumab administration despite LTBI treatment. Tuberculosis reactivation was not detected in sputum or urine but was detected from the terminal ileal mucosa...
Source: Internal Medicine - November 27, 2019 Category: Internal Medicine Tags: Intern Med Source Type: research

Tuberculous chancre in a foot leading to a disseminated tuberculosis infection.
Authors: Fernandez-Nieto D, de Perosanz-Lobo D, Ortega-Quijano D, Jimenez-Cauhe J, Fernandez-Gonzalez P, Bea-Ardebol S PMID: 31760728 [PubMed - as supplied by publisher] (Source: Giornale Italiano di Dermatologia e Venereologia)
Source: Giornale Italiano di Dermatologia e Venereologia - November 27, 2019 Category: Dermatology Tags: G Ital Dermatol Venereol Source Type: research

Comparison of anterior transthoracic debridement and fusion with posterior transpedicular debridement and fusion in the treatment of mid-thoracic spinal tuberculosis in adults
The surgical procedures for mid-thoracic spinal tuberculosis mainly include anterior transthoracic debridement and fusion and posterior transpedicular debridement and fusion. Until now, the surgical choice is ... (Source: BMC Musculoskeletal Disorders)
Source: BMC Musculoskeletal Disorders - November 27, 2019 Category: Orthopaedics Authors: Weiwei Li, Zheng Liu, Xiao Xiao, Zhen Zhang and Xiyang Wang Tags: Research article Source Type: research

Mycobacterium tuberculosis Drives Expansion of Low-Density Neutrophils Equipped With Regulatory Activities
In human tuberculosis (TB) neutrophils represent the most commonly infected phagocyte but their role in protection and pathology is highly contradictory. Moreover, a subset of low-density neutrophils (LDNs) has been identified in TB, but their functions remain unclear. Here, we have analyzed total neutrophils and their low-density and normal-density (NDNs) subsets in patients with active TB disease, in terms of frequency, phenotype, functional features, and gene expression signature. Full-blood counts from Healthy Donors (H.D.), Latent TB infected, active TB, and cured TB patients were performed. Frequency, phenotype, burs...
Source: Frontiers in Immunology - November 27, 2019 Category: Allergy & Immunology Source Type: research

Emerging opportunities of exploiting mycobacterial electron transport chain pathway for drug-resistant tuberculosis drug discovery
. (Source: Expert Opinion on Drug Discovery)
Source: Expert Opinion on Drug Discovery - November 27, 2019 Category: Drugs & Pharmacology Authors: Kuldeep K. Roy Mushtaq Ahmad Wani Source Type: research

The Necessity of Anti-Tuberculosis Therapy after Resection of Pulmonary Tuberculous Nodules: A Single Center Retrospective Study.
CONCLUSIONS: Postoperative recurrence of tuberculosis is rare, anti-tuberculosis treatment seems unnecessary for asymptomatic pulmonary tuberculous nodules. Adverse drug reactions should not be ignored. PMID: 31776302 [PubMed - as supplied by publisher] (Source: Annals of Thoracic and Cardiovascular Surgery)
Source: Annals of Thoracic and Cardiovascular Surgery - November 27, 2019 Category: Cardiovascular & Thoracic Surgery Authors: Wang C, Liu Y, Lin H, Yang L, Yan D, Gong C, Liu S Tags: Ann Thorac Cardiovasc Surg Source Type: research

Lytic Lesion of the Sternum Due to Tuberculosis.
iz Calle JC PMID: 31785886 [PubMed - as supplied by publisher] (Source: Archivos de Bronconeumologia)
Source: Archivos de Bronconeumologia - November 27, 2019 Category: Respiratory Medicine Authors: Pinos Vélez N, León Cabrera O, Torracchi Carrasco M, Vazquez Albornoz J, Ortiz Calle JC Tags: Arch Bronconeumol Source Type: research

High yield of new HIV diagnoses during active case-finding for tuberculosis
Conclusion: We observed a high yield of new HIV diagnoses among adults identified by active application of a broad symptom screen. Use of integrated tuberculosis and HIV screening could help close the detection gap for both conditions. (Source: AIDS)
Source: AIDS - November 26, 2019 Category: Infectious Diseases Tags: CONCISE COMMUNICATION Source Type: research

High incidence of tuberculosis in the first year of antiretroviral therapy in the Botswana National antiretroviral therapy programme between 2011 and 2015
Conclusion: We report a high incidence of TB within the first year of ART and in patients with advanced immunodeficiency. Improved screening strategies and virologic monitoring during this early period on ART, coupled with TB preventive treatment, will reduce the burden of TB. (Source: AIDS)
Source: AIDS - November 26, 2019 Category: Infectious Diseases Tags: Epidemiology and Social Source Type: research

Treatment for latent tuberculosis infection in low- and middle-income countries: progress and challenges with implementation and scale-up.
Authors: Harries AD, Kumar AMV, Satyanarayana S, Takarinda KC, Timire C, Dlodlo RA Abstract Introduction: Treatment of latent tuberculosis infection (LTBI) is a crucial but neglected component of global tuberculosis control. The 2018 United Nations High-Level Meeting committed world leaders to provide LTBI treatment to at least 30 million people, including 4 million children
Source: Expert Review of Respiratory Medicine - November 26, 2019 Category: Respiratory Medicine Tags: Expert Rev Respir Med Source Type: research