Compensatory evolution in NusG improves fitness of drug-resistant M. tuberculosis
Nature, Published online: 20 March 2024; doi:10.1038/s41586-024-07206-5In Mycobacterium tuberculosis, the fitness cost of rifampicin resistance is partially due to excessive RNA polymerase pausing and is rescued by mutations in the pro-pausing transcription factor NusG. (Source: Nature AOP)
Source: Nature AOP - March 20, 2024 Category: Research Authors: Kathryn A. Eckartt Madeleine Delbeau Vanisha Munsamy-Govender Michael A. DeJesus Zachary A. Azadian Abhijna K. Reddy Joshua Chandanani Nicholas C. Poulton Stefany Qui ñones-Garcia Barbara Bosch Robert Landick Elizabeth A. Campbell Jeremy M. Rock Source Type: research

Diagnostic Utility of QuantiFERON-Gold Testing in Patients with Ocular Inflammation in a Low-Endemic Tuberculosis Region
To evaluate the diagnostic value of QuantiFERON Gold (QFT-G) testing for ocular inflammation in a low prevalence tuberculosis (TB) area. (Source: American Journal of Ophthalmology)
Source: American Journal of Ophthalmology - March 20, 2024 Category: Opthalmology Authors: Julia Xia, Alan G. Palestine, Amit K. Reddy Tags: Original Articles Source Type: research

Leveraging Transportation Providers to Deploy Lay First Responder (LFR) Programs in Three sub-Saharan African Countries without Formal Emergency Medical Services: Evaluating Longitudinal Impact and Cost-Effectiveness
Injury is the leading cause of death for people aged 15-45, accounting for 32% more mortality than malaria, tuberculosis, and HIV/AIDS combined.[1] Road traffic injuries (RTIs) are the largest contributor to global injuries and among the five leading causes of disability-adjusted life years (DALYs).[2] RTIs disproportionately affect low- and middle-income countries (LMICs), comprising 96% of the 25 countries with the greatest RTI-related DALY burden, and decreasing GDP by an estimated 6%.[3] Motorcycle taxis are the fastest-growing form of informal transportation due to a lack of affordable publicly-funded alternatives, be...
Source: Injury - March 20, 2024 Category: Orthopaedics Authors: Peter G. Delaney, Zachary J. Eisner, Haleigh Pine, Max Klapow, Alfred Harun Thullah, Richard Bamuleke, Issa Mohamet Nuur, Krishnan Raghavendran Source Type: research

IL-10 and TGF- β1 may weaken the efficacy of preoperative anti-tuberculosis therapy in older patients with spinal tuberculosis
In conclusion, there are some differences in imaging, pathological, and immune features of spinal tuberculosis in different age groups. The high expression of IL-10 and TGF-β1 in older patients may weaken their anti-tuberculosis immunity and treatment effectiveness. (Source: Frontiers in cellular and infection microbiology)
Source: Frontiers in cellular and infection microbiology - March 20, 2024 Category: Microbiology Source Type: research

HadBD dehydratase from Mycobacterium tuberculosis fatty acid synthase type II: A singular structure for a unique function
AbstractWorldwide, tuberculosis is the second leading infectious killer and multidrug resistance severely hampers disease control. Mycolic acids are a unique category of lipids that are essential for viability, virulence, and persistence of the causative agent,Mycobacterium tuberculosis (Mtb). Therefore, enzymes involved in mycolic acid biosynthesis represent an important class of drug targets. We previously showed that the (3R)-hydroxyacyl-ACP dehydratase (HAD) protein HadD is dedicated mainly to the production of ketomycolic acids and plays a determinant role inMtb biofilm formation and virulence. Here, we discovered tha...
Source: Protein Science - March 19, 2024 Category: Biochemistry Authors: Pascaline Bories, Julie Rima, Samuel Tranier, Julien Marcoux, Yasmina Grimoire, Mathilde Tomaszczyk, Anne Launay, Karine Fata, Hedia Marrakchi, Odile Burlet ‐Schiltz, Lionel Mourey, Manuelle Ducoux‐Petit, Fabienne Bardou, Cécile Bon, An Tags: RESEARCH ARTICLE Source Type: research

Biochemical and structural characterization reveals Rv3400 codes for β‐phosphoglucomutase in Mycobacterium tuberculosis
This study further helps in understanding the role of β-PGM in the physiology of Mtb. (Source: Protein Science)
Source: Protein Science - March 19, 2024 Category: Biochemistry Authors: Latika Singh, Subramanian Karthikeyan, Krishan Gopal Thakur Tags: RESEARCH ARTICLE Source Type: research

Interferon Upregulation Associates with Insulin Resistance in Humans
Curr Diabetes Rev. 2024 Mar 18. doi: 10.2174/0115733998294022240309105112. Online ahead of print.ABSTRACTIn humans, insulin resistance is a physiological response to infections developed to supply sufficient energy to the activated immune system. This metabolic adaptation facilitates the immune response but usually persists after the recovery period of the infection and predisposes the hosts to type 2 diabetes and vascular injury. In patients with diabetes, superimposed insulin resistance worsens metabolic control and promotes diabetic ketoacidosis. Pathogenic mechanisms underlying insulin resistance during microbial invas...
Source: Current Diabetes Reviews - March 19, 2024 Category: Endocrinology Authors: Maria M Adeva-Andany Natalia Carneiro-Freire Elvira Castro-Quintela Eva Ameneiros-Rodriguez Lucia Adeva-Contreras Carlos Fernandez-Fernandez Source Type: research

Interferon Upregulation Associates with Insulin Resistance in Humans
Curr Diabetes Rev. 2024 Mar 18. doi: 10.2174/0115733998294022240309105112. Online ahead of print.ABSTRACTIn humans, insulin resistance is a physiological response to infections developed to supply sufficient energy to the activated immune system. This metabolic adaptation facilitates the immune response but usually persists after the recovery period of the infection and predisposes the hosts to type 2 diabetes and vascular injury. In patients with diabetes, superimposed insulin resistance worsens metabolic control and promotes diabetic ketoacidosis. Pathogenic mechanisms underlying insulin resistance during microbial invas...
Source: Current Diabetes Reviews - March 19, 2024 Category: Endocrinology Authors: Maria M Adeva-Andany Natalia Carneiro-Freire Elvira Castro-Quintela Eva Ameneiros-Rodriguez Lucia Adeva-Contreras Carlos Fernandez-Fernandez Source Type: research

Interferon Upregulation Associates with Insulin Resistance in Humans
Curr Diabetes Rev. 2024 Mar 18. doi: 10.2174/0115733998294022240309105112. Online ahead of print.ABSTRACTIn humans, insulin resistance is a physiological response to infections developed to supply sufficient energy to the activated immune system. This metabolic adaptation facilitates the immune response but usually persists after the recovery period of the infection and predisposes the hosts to type 2 diabetes and vascular injury. In patients with diabetes, superimposed insulin resistance worsens metabolic control and promotes diabetic ketoacidosis. Pathogenic mechanisms underlying insulin resistance during microbial invas...
Source: Current Diabetes Reviews - March 19, 2024 Category: Endocrinology Authors: Maria M Adeva-Andany Natalia Carneiro-Freire Elvira Castro-Quintela Eva Ameneiros-Rodriguez Lucia Adeva-Contreras Carlos Fernandez-Fernandez Source Type: research

Interferon Upregulation Associates with Insulin Resistance in Humans
Curr Diabetes Rev. 2024 Mar 18. doi: 10.2174/0115733998294022240309105112. Online ahead of print.ABSTRACTIn humans, insulin resistance is a physiological response to infections developed to supply sufficient energy to the activated immune system. This metabolic adaptation facilitates the immune response but usually persists after the recovery period of the infection and predisposes the hosts to type 2 diabetes and vascular injury. In patients with diabetes, superimposed insulin resistance worsens metabolic control and promotes diabetic ketoacidosis. Pathogenic mechanisms underlying insulin resistance during microbial invas...
Source: Current Diabetes Reviews - March 19, 2024 Category: Endocrinology Authors: Maria M Adeva-Andany Natalia Carneiro-Freire Elvira Castro-Quintela Eva Ameneiros-Rodriguez Lucia Adeva-Contreras Carlos Fernandez-Fernandez Source Type: research

Use of multiple pharmacodynamic measures to deconstruct the Nix-TB regimen in a short-course murine model of tuberculosis
Antimicrob Agents Chemother. 2024 Mar 19:e0101023. doi: 10.1128/aac.01010-23. Online ahead of print.ABSTRACTA major challenge for tuberculosis (TB) drug development is to prioritize promising combination regimens from a large and growing number of possibilities. This includes demonstrating individual drug contributions to the activity of higher-order combinations. A BALB/c mouse TB infection model was used to evaluate the contributions of each drug and pairwise combination in the clinically relevant Nix-TB regimen [bedaquiline-pretomanid-linezolid (BPaL)] during the first 3 weeks of treatment at human equivalent doses. The...
Source: Antimicrobial Agents and Chemotherapy - March 19, 2024 Category: Microbiology Authors: M A Lyons A Obregon-Henao M E Ramey A A Bauman S Pauly K Rossmassler J Reid B Karger N D Walter G T Robertson Source Type: research

Interferon Upregulation Associates with Insulin Resistance in Humans
Curr Diabetes Rev. 2024 Mar 18. doi: 10.2174/0115733998294022240309105112. Online ahead of print.ABSTRACTIn humans, insulin resistance is a physiological response to infections developed to supply sufficient energy to the activated immune system. This metabolic adaptation facilitates the immune response but usually persists after the recovery period of the infection and predisposes the hosts to type 2 diabetes and vascular injury. In patients with diabetes, superimposed insulin resistance worsens metabolic control and promotes diabetic ketoacidosis. Pathogenic mechanisms underlying insulin resistance during microbial invas...
Source: Current Diabetes Reviews - March 19, 2024 Category: Endocrinology Authors: Maria M Adeva-Andany Natalia Carneiro-Freire Elvira Castro-Quintela Eva Ameneiros-Rodriguez Lucia Adeva-Contreras Carlos Fernandez-Fernandez Source Type: research

Efficacy and safety of pharmacological treatment of psoriatic arthritis: a systematic literature research informing the 2023 update of the EULAR recommendations for the management of psoriatic arthritis
CONCLUSION: The results of this SLR informed the task force responsible for the 2023 update of the European Alliance of Associations for Rheumatology recommendations for pharmacological management of PsA.PMID:38503473 | DOI:10.1136/ard-2024-225534 (Source: Herpes)
Source: Herpes - March 19, 2024 Category: Infectious Diseases Authors: Andreas Kerschbaumer Josef S Smolen Ricardo J O Ferreira Heidi Bertheussen Xenofon Baraliakos Daniel Aletaha Dennis G McGonagle D ésirée van der Heijde Iain B McInnes Bente Appel Esbensen Kevin L Winthrop Wolf-Henning Boehncke Jan W Schoones Laure Gosse Source Type: research

A Comprehensive Examination of Heterocyclic Scaffold Chemistry for Antitubercular Activity
Chem Biodivers. 2024 Mar 18:e202400067. doi: 10.1002/cbdv.202400067. Online ahead of print.ABSTRACTTuberculosis is a communicable disease which affects humans particularly the lungs and is transmitted mainly through air. Despite two decades of intensive research aimed at understanding and combating tuberculosis, persistent biological uncertainties continue to hinder progress. Nowadays, heterocyclic compounds have proven themselves in effective treatment of tuberculosis because of their wide range of biological and pharmacological activities. Antituberculosis or antimycobacterial agents encompass a broad array of compounds ...
Source: Chemistry and Biodiversity - March 19, 2024 Category: Biochemistry Authors: Anjaneyulu Bendi Priyanka Yadav Komal Saini Anirudh Singh Bhathiwal Neera Raghav Source Type: research

Use of multiple pharmacodynamic measures to deconstruct the Nix-TB regimen in a short-course murine model of tuberculosis
Antimicrob Agents Chemother. 2024 Mar 19:e0101023. doi: 10.1128/aac.01010-23. Online ahead of print.ABSTRACTA major challenge for tuberculosis (TB) drug development is to prioritize promising combination regimens from a large and growing number of possibilities. This includes demonstrating individual drug contributions to the activity of higher-order combinations. A BALB/c mouse TB infection model was used to evaluate the contributions of each drug and pairwise combination in the clinically relevant Nix-TB regimen [bedaquiline-pretomanid-linezolid (BPaL)] during the first 3 weeks of treatment at human equivalent doses. The...
Source: Antimicrobial Agents and Chemotherapy - March 19, 2024 Category: Microbiology Authors: M A Lyons A Obregon-Henao M E Ramey A A Bauman S Pauly K Rossmassler J Reid B Karger N D Walter G T Robertson Source Type: research