Accuracy of pleural fluid c-reactive protein in differentiating between tuberculous and malignant pleural effusions: a meta-analysis
Conclusion: p-CRP determination is a relatively accurate test for discriminating TPE from MPE. The samples included in this study were only those with a definitive diagnosis. Further studies evaluate whether p-CRP has utility for effusions which are non-diagnostic for the gold-standard diagnostic tests. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Angeles, R. R. B., King, R. E., Benedicto, J., Rivera, A. Tags: Tuberculosis Source Type: research

Over diagnosis of smear negative pulmonary tuberculosis in patients with allergic bronchopulmonary aspergillosis: A study from high tuberculosis burden country
Conclusion: Patient with ABPA frequently received empiric ATT as smear –ve TB in high TB burden country. This results in over diagnosis of TB and unnecessary use of global resource. Moreover dealy in diagnosis leads to long term complications. Awareness regarding ABPA is required in high TB burden countries. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Iqbal, N., Irfan, M., Riaz, U., Saeed, S., Amir Sheikh, M. D., Awan, S., Zubairi, A. Tags: Tuberculosis Source Type: research

Adverse effects of anti-tuberculosis drugs in hemodialysis patients
Conclusions: Most of hemodialysis patients with newly diagnosed tuberculosis received complete scheme of anti-tuberculosis treatment (77.8%). The first-line TB drugs were oftener used (57.1%). The most adverse effects were neurotoxicity (26.9%) and hepatotoxicity (15.4%). TB treatment was cancelled due to Pt –50%, R – 37.5%, and Z – 37. 5%. Mfx, Spx, Cs, Ter, Pas, Lzd, Bq were used less often, but demonstrated higher safety. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Gordeeva, O., Karpina, N., Vedernikova, R., Schultz, I., Bagdasarian, A. Tags: Tuberculosis Source Type: research

Chest radiologic pattern in Diabetic patients with Pulmonary Tuberculosis (PTB)
Introduction: DM is known to increase the risk of active TB disease approximately 3 fold, and contributes to adverse TB treatment outcomes such as death, treatment failure and relapse. There are no studies in Indian subjects comparing the radiologic pattern in pulmonary TB patients with DM (PTB-DM) and those without DM (PTB-only).Aims and Objectives: To describe and compare the pattern and extent of radiological involvement in PTB-only, PTB-DMTo assess the early treatment response between the groups. Methods: Ours is a retrospective study of radiographs of consecutive patients with PTB diagnosed in the department of pulmon...
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Christopher, D. J., Cherian Kuruvilla, L., Sarangi, P. K., Thangakunam, B., Irodi, A., Shankar, D. Tags: Tuberculosis Source Type: research

Risk Factors for tuberculosis in patients on anti-TNF treatment
This study showed that patients on anti-TNF treatment had a high rate of TB despite INH prophylaxis, but no risk factor for TB development could be identified. Mild hepatotoxicity frequently develops during LTBI treatment. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Kaptan, Y., Sunel, A., Tas, M. N., Oksel, F., Aksu, K., Sayıner, A. Tags: Tuberculosis Source Type: research

Study on prevalence and associated factors of Diabetes Mellitus among Tuberculosis Patients in Iran
Introduction: Multiple studies have proposed that diabetes mellitus increases the risk of active tuberculosis. The increasing prevalence of diabetes mellitus in tuberculosis endemic areas may adversely impact on spreading of tuberculosis. Scope of this study is assessment of prevalence of diabetes mellitus and associated factors in pulmonary tuberculosis.Method and Material: This case control study was carried out on pulmonary tuberculosis during a period of 12 years from 2004-2016 in Iran. The control group were symptomatic respiratory patients without preceding history of active pulmonary tuberculosis in the same clinic....
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Mozaffari, A., Hendiani, M. Tags: Tuberculosis Source Type: research

Influence of diabetes mellitus on sputum conversion rate in pulmonary tuberculosis and on antituberculous drug resistance
Background: Diabetes mellitus (DM) has an influence on many aspects of tuberculosis (TB).Objectives: to correlate the influence of diabetes mellitus on sputum conversion rate and antituberculous drug resistance.Methods: The study comprised 194 pulmonary tuberculosis (PTB) patients divided in two groups, i.e. the group of TB associated with DM and the group of patients affected only by TB. Sputum smear and liquid culture (MGIT 960) examination were performed at TB diagnosis and subsequently at completion of the initial phase as well as during the continuation phase of TB treatment. Drug sensitivity test (DST) was also perfo...
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Paralija, B., Mujakovic, A. Tags: Tuberculosis Source Type: research

Prevention and mechanism of undesirable adverse reactions in patients with pulmonary tuberculosis with extensive drug-resistance (XDR) combined with type 2 diabetes
Treatment of patients with tuberculosis with XDR combined with diabetes mellitus (DM) is difficult due to the more frequent development of neurotoxic unwanted adverse reactions (UAR) against the background of diabetic neuropathy.Objective: to assess the tolerability of the V chemotherapy regimen, including bedaquiline (Sirturo®) and linezolid (Zivox®) in patients with pulmonary tuberculosis with XDR combined with diabetes when prescribing thioctic acid (Thioctacid®) for the prevention and relief of UAR.126 TB patients with XDR and type 2 DM were observed: main group 1G (n = 66 people) and comparison group 2G (n...
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Shovkun, L., Kudlay, D., Nikolenko, N., Campos, E., Franchuk, I. Tags: Tuberculosis Source Type: research

Erectile dysfunction in pulmonary tuberculosis: Is there an association?
Conclusion: Pulmonary TB has negative impact on male sexual function. Thus, sexual problems should be in mind during assessment and evaluation of patient with tuberculosis. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Metwally, A., Magdy, D., Ahmed, R. Tags: Tuberculosis Source Type: research

Unusual presentations of tuberculosis in East London
Conclusion: Isolated ENT lesions (not-including lymph node TB) remain a rare but important cause of TB and atypical presentations render diagnosis challenging. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Pang, D., Skyllberg, E., Waite, M., Rahman, A., Burman, M., Tiberi, S., Kunst, H. Tags: Tuberculosis Source Type: research

Comorbidity: pulmonary tuberculosis and chronic obstructive pulmonary disease
Conclusions: COPD has an aggravating effect on the course of tuberculosis, contributes to the development of severe chronic forms of the disease, which complicates treatment of patients. In the presence of COPD in patients with pulmonary tuberculosis, therapy adjustment is required to improve the effectiveness of TB treatment. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Jakimova, M. A., Karpina, N., Gordeeva, O., Asanov, R. Tags: Tuberculosis Source Type: research

Newly detected pulmonary tuberculosis in patients combined with diabetes mellitus and without it
Aim: Comparison of clinical features of pulmonary tuberculosis (TB) in patients with TB combined diabetes mellitus (DM) and without it.Methods: We studied 207 patients with newly detected TB combined with DM. The comparison group involved 197 patients with newly detected TB without DM.Results: It was found that the comparison groups did not differ by sex. Significant differences were found in the age of patients in comparison groups. In the majority of patients with newly diagnosed TB and combined DM, the age was above 40 years (63,2%), but in the group without DM ranged from 18 to 39 years (88,0%).A comparative analysis o...
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Komissarova, O., Abdullaev, R., Aleshina, S. Tags: Tuberculosis Source Type: research

Markers of thyroid dysfunction in patients with MDR tuberculosis
Conclusion: The use of ethionamide/ protionamide and PAS in patients with newly detected MDR TB was accompanied by symptoms of hypothyroidism during the entire period of observation. Most often, these changes were detected in the first two months of chemotherapy. The most pronounced pathological changes in the indicators of thyroid function were observed at 4 and 5 months of treatment. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Chumakova, Y., Abdullaev, R., Komissarova, O., Odinets, V. Tags: Tuberculosis Source Type: research

Transthyretin in patients with pulmonary tuberculosis combined with diabetes
Conclusions: The quantitative analysis of nutritional status has confirmed that TB patient with concomitant DM is characterized by an increase in BMI in the background of deficiency of protein. Sensitive indicator of nutritional status in patients TB combined with DM was level of TTR. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Abdullaev, R., Komissarova, O., Berejnaya, O. Tags: Tuberculosis Source Type: research

Predictors of tuberculosis in injection drug users
Conclusion: social vulnerable and comordid IDUs have high risk for TB. They should be screened annually and have an individualized approach for preventing low treatment outcome. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Cotelea, E., Lesnic, E. Tags: Tuberculosis Source Type: research

Prevalence of CNS lesions in patients with pulmonary tuberculosis and HIV infection
Conclusion: the risk of CNS damage is higher in patients who did not receive antiretroviral therapy when the number of CD4 lymphocytes ≤ 100; the most common etiology of CNS is tuberculosis; for patients who did not receive antiretroviral therapy with CD4 ≤100, it is necessary to include brain neuroimaging techniques and the study of cerebrospinal fluid in the diagnostic algorithm. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Stavitskaya, N., Smerdin, S., Pashukhin, A., Chernova, I. Tags: Tuberculosis Source Type: research

Indicaions to surgery for lung tuberculomas today
Conclusions: Examination of surgical material ensures verification of the diagnosis, determination of MDR/XDR MBT and lung cells, creates conditions for adequate chemotherapy. All of these proves the necessity of surgical treatment for lung tuberulomas. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Krasnikova, E., Lepeha, L., Tarasov, R., Erokhina, M., Aliev, V., Sadovnikova, S., Bagirov, M. Tags: Tuberculosis Source Type: research

A mycobacterial encoded hypothetical protein is localized in mitochondria and regulates oxidative phosphorylation of infected macrophage
Conclusion: We identified a conserved hypothetical protein (Rv0674) from Mtb infected mitochondrial fractions of macrophages. The gene of this protein was decoded and characterized through a series of molecular approaches by recombinantly expressing it in MSMEG. The protein was found to be localized in the mitochondria of infected macrophages, in the macrophages of BAL fluid and drug resistant cases. Rv0674 plays significant roles in the apoptosis of infected macrophages, regulating mitochondrial proteins of the OXPHOS complexes which lead to ATP production and mitochondrial membrane potential. It is responsible for prolon...
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Dubey, R. K., Dhamija, E., Mishra, A. K., Soam, D., Yabaji, S. M., Srivastava, K., Srivastava, K. K. Tags: Tuberculosis Source Type: research

Chest CT scan as an initial diagnostic method for tuberculosis infection detected by mass screening in the intermediate-burden country
Conclusion: CT was not supported as an initial diagnostic method to rule out active TB in patients with TB infection confirmed by mass screening in an intermediate-burden country, because it did not show difference in detecting active TB despite increasing further invasive tests. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Lee, J.-K., Joo, D.-H., Heo, E. Y., Kim, D. K., Chung, H. S. Tags: Tuberculosis Source Type: research

N-acetylcysteine and mortality in hospitalized pulmonary tuberculosis infection
Conclusion: NAC was significantly associated with a reduction of all-cause mortality within 90 days after admission in patients with PTB. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Jeeraaumponwat, T. Tags: Tuberculosis Source Type: research

Drug resistance of Mycobacterium tuberculosis in the Ural region of Russian Federation
Conclusions: In the Ural regions there is distribution of MDR strains with high level DR to first and second line drugs including XDR TB among new TB cases and retreatment cases in 12.2% and 19.0% respectively. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Filatova, E., Testov, V., Glebov, K., Medvinsky, I., Panova, A., Burmistrova, I., Sterlikov, S., Filina, E. Tags: Tuberculosis Source Type: research

Increased FDG uptake on 18F-FDG PET/CT in residual lesions of tuberculosis
Conclusion: Among residual lesion types, the infiltration with higher SUVmax could be important type related to activity at treatment completion. More study with bigger population is needed. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Lee, M., Jang, J., Yoon, S., Lee, J., Jeong, I., Lee, Y. Tags: Tuberculosis Source Type: research

Radiologic pattern as a predictor of multi-drug resistant tuberculosis; a multicenter study
This report was part of a multicenter study titled Tuberculosis Research of INA-RESPOND on Drug Resistance (TRIPOD). We determined DR-TB using Xpert MTB/Rif and drug susceptibility test with Ogawa or MGIT and baseline CXR for radiologic appearance. Ethical clearance has been approved by NIHRD of MoH.There were 297 subjects with average age were 40 years old, mostly were male (61%), 160 (54%) primary TB, and almost half of them were DR-TB (49%). About 35% of DR-TB were primary cases. Radiologic appearance showed that DR-TB cases had cavity more than DS-TB (63.3% vs 37.3%, p
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Handayani, D., Fajarwati, I., Priyonugroho, G., Burhan, E., Kusmiati, T., Muzakkir, I., Siagian, P., Riyanto, B. S., Wibisono, B. H., Sajinadiyasa, I. G. K., Susanto, N. H. Tags: Tuberculosis Source Type: research

Active case finding for tuberculosis among prisoners in Karachi, Pakistan
Conclusion: Active screening results in substantially high TB yield among prisoners. Screening for TB and ensuring treatment success among TB patients in the prisons in a high TB burden country is integral to TB control in the country.Table 1.Yield of TB among prisoners in District Prison Malir, Karachi.IndicatorsN%No. of prisoners screened6527100Presumptive cases4707.2Xpert tests run3745.7MTB +170.3Clinically diagnosed1001.5yield/ screened1.8yield/presumptive24.9 (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Jamal, W., Azeemi, K., Waqar, M., Ikram, K., Zaidi, S. M. A., Habib, S. Tags: Tuberculosis Source Type: research

Utilizing chest X-ray based active case finding approach for early tuberculosis case detection in Pakistan
Introduction: Pakistan has the third largest number of people with undiagnosed TB among the 22 high TB-burden countries. Case detection gap results in late disease presentation, with poor disease outcomes, and undiagnosed cases spreading infection. To bridge this gap, active case finding (ACF) using pre-screening tools such as chest X-ray can be used to detect TB early in the course of illness while MTB burden is still low.Methodology: Retrospective data from Xpert MTB/RIF testing carried out at TB centers, called "Sehatmand Zindagi" centers, in Pakistan, from January to December 2018 was analyzed. The referrals ...
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Habib, S., Azeemi, K., Zaidi, S. M. A., Jamal, W., Kazmi, T., Waqar, M. Tags: Tuberculosis Source Type: research

Radiological patterns of different variants of disseminated pulmonary TB
Aim: Differential diagnosis of genesis and course of disseminated pulmonary TB (DPT) based on multi-sectional CT (MSCT) and single-photon emission CT (SPECT) with 99m Tc-technetril data.Material and Methods: We analyzed MSCT data from 78 cases with new DPT and the use of SPECT with 99m Tc-technetril in 23 of these cases. Hematogenic dissemination was observed in 7 (10%) cases, lymphohematogenic – 42 (60%), and lymphobronchogenic – 21 (30%). There were 36 (46.2%) women, 42 (53.8%) men. Sixty-three (80.8%) cases were detected at patients’ referrals, 15 (19.2%) – at fluorography screening.Results: Thir...
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Amansahedov, R., Dmitrieva, L., Lepekha, L., Kazho, R., Sigaev, A., Ergeshov, A. Tags: Tuberculosis Source Type: research

The use of a simplified chest X-ray evaluation score for the assessment of tuberculosis
This study aimed to compare an established score (Timika, 1-140 points) with the proposed simplified score (SRS-TB, 1-8 points) for analyzing chest X-rays of patients with susceptible and MDR tuberculosis, to assess the validity of SRS-TB, and to try to suspect MDR-TB at the time of initial diagnosis.Both scores were applied to chest X-rays at diagnosis from 132 patients (susceptible TB) and 102 patients (MDR-TB). Results were correlated to treatment outcome. Mean Timika score was 55.9% for susceptible TB and 81.17% for MDR-TB. Mean SRS-TB was 5.24 for susceptible TB and 6.73 for MDR-TB. Most MDR-TB cases scored 7 and 8. T...
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Strambu, I. R., Paun, A., Zaharia, D. C., Sora, A., Panciu, T. Tags: Tuberculosis Source Type: research

Pulmonary tuberculosis Sequelae: a health problem in the north of Tunisia
Conclusion: Pulmonary TB Sequelae is a health problem in the north of Tunisia particularly in elderly. The national program of TB will reduce the incidence of this disease. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Zneigui, T., Sifi, I., Ouertani, H., Abidi, R., Maaroufi, N., Aouadi, S. Tags: Tuberculosis Source Type: research

Predictors of treatment failure among pulmonary tuberculosis patients in Pakistan
Conclusion: Sputum grade at 2 month follow up, age and MTB burden at baseline are important predictors of failure. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Habib, S., Zaidi, S. M. A., Jamal, W., Zafar, I., Kazmi, T., Yasir, M. Tags: Tuberculosis Source Type: research

Evaluation of the effect of Category I anti tuberculous therapy on the vitamin D status of pulmonary tuberculosis patients
The objective of this study was to evaluate and compare serum Vitamin D status in PTB patients before and after ATT to substantiate the supplementation of Vitamin D in PTB patients.Materials and Methods: A single centre, prospective, observational study was carried out after institutional ethical community approval and written informed consent from 50 PTB patients on category I, above 18 years of age of both the sexes. Vitamin D samples were collected at baseline, 2 months and at the end of 6 months. Analysis using RIA, was done at the end of the study, to eliminate bias.Results: The mean vitamin D level of the study popul...
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Tandon, A., Gupta, K. B., Kumar, V., Singh, V. Tags: Tuberculosis Source Type: research

Dynamics of carbohydrate metabolism in patients with destructive pulmonary tuberculosis
Conclusion: Our findings suggest that carbohydrate metabolism disorders are more expressed and have sluggish positive dynamics in PTB patients who still have cavities in the lung tissue after 2 months of treatment, compared to those with healed cavities. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Shvets, O. Tags: Tuberculosis Source Type: research

Recurrent tuberculosis among HIV-infected patients in Novokuznetsk, Russia
Conclusion: recurrent HIV/TB cases had high MDR and mortality rate, the majority were noncompliant to ART. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Viktorova, I., Zimina, V., Dolgikh, S., Degtyareva, S., Khanin, A. Tags: Tuberculosis Source Type: research

Transition from restrictive to obstructive lung function impairment during treatment and follow-up of active pulmonary tuberculosis
We examined the progression of changes in lung physiology in patients treated for PTB.Adult patients receiving treatment for a first episode of tuberculosis were prospectively followed with serial lung physiology and quantitative CT lung scans performed at baseline, 2, 6, 12 and 18-months during and after completion of treatment.Forty-nine patients (median age 26 years; 37.2% males) were included, and 43 studied. During treatment, lung volumes improved and CT fibrosis score decreased, but features of AFO and gas trapping emerged, and reduced diffusing capacity, seen in a majority of patients persisted. One year after compl...
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Allwood, B., Maasdorp, E., Kim, G., Cooper, C., Goldin, J., Van Zyl-Smit, R., Bateman, E., Dawson, R. Tags: Tuberculosis Source Type: research

Fenofibrate is associated with higher risk of mortality in patients with tuberculosis infection
Objectives: Mycobacterium tuberculosis (Mtb) is an intracellular pathogen that infects and persists in foamy macrophages, which causes tuberculosis (TB). Regulating cholesterol in macrophages may affect the intracellular growth of Mtb. However, the association between lipid-lowering therapy and TB disease remains unclear. The aim of the study is to investigate the use of fenofibrate, a lipid-lowering drug, and its outcome in patients with TB infection.Methods: Nationwide epidemiological data from the National Health Insurance Research Database of Taiwan were used. Patients with new onset of TB and those who had ever been p...
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Liu, C.-L., Lu, Y.-T., Chien, W.-C., Chung, C.-H. Tags: Tuberculosis Source Type: research

The increasing trend of nontuberculous mycobacterial pulmonary diseases in a tertiary referral hospital in South Korea between 2006 and 2016
Background: The incidence of nontuberculous mycobacteria (NTM) infection is increasing worldwide. The aim of the study was to investigate the long-term epidemiologic trends in the NTM recovery rate and NTM pulmonary disease (NTM-PD) over a recent 11-year period in South Korea.Methods: We reviewed the laboratory records of respiratory samples cultured for mycobacteria from January 2006 to December 2016 at Severance Hospital, a tertiary referral hospital in South Korea. The medical records of patients with positive NTM were also reviewed.Results: During the study period, 33,044 respiratory specimens from 9,236 patients were ...
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Park, Y., Kim, C. Y., Park, M. S., Kim, Y. S., Chang, J., Kang, Y. A. Tags: Respiratory infections Source Type: research

Screening non-tuberculous mycobacteria in patients with bronchiectasis
Conclusion: NTM isolations are low in our area. As well as revealing the true prevalence in each area, routine screening for NTM in bronchiectasis permits early detection and treatment. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Torrente Nieto, A., Munoz Castro, G., Plana Pes, M., Segovia Calero, P., Buxo Pujolras, M., Motje Casas, M., Redondo Martin, M. J., Vendrell Relat, M. Tags: Respiratory infections Source Type: research

Clinical, Radiological, Microbiological and pulmonary function Spectrum of Post Tubercular Bronchiectasis A Contemporary Study from Tertiary Care Centre
Conclusion: In patients with bronchiectasis from northern India generally presenting with recurrent cough, hemoptysis, dyspnea, the etiology remains mainly post tubercular. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Bajpai, J., Pandey, M. K., Kant, S., Pradhan, A. Tags: Respiratory infections Source Type: research

Prevalence of non-tuberculous mycobacterial disease among patients evaluated for pulmonary tuberculosis in Iraq 2015-2018
Conclusions: NTM-PD presented in a rate of 1.6% out of patients evaluated for PTB with a male to female ratio of 2:1 and the dominant subtype is M.kansassi (50%). (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Al-Salihi, L., Mankhi, A., Ali, R., Tbena, M. Tags: Respiratory infections Source Type: research

Characteristics of drug susceptibility of M. abscessus subsp. abscessus and M.chelonae
Introduction: Non-tuberculous mycobacteria (NTM) are emerging as important pathogens. The drug susceptibility of rapidly growing mycobacteria (RGM) varies among isolates. Treatment strategies vary depending on the isolate and also differ from those of Mycobacterium tuberculosis. However, studies on antimicrobial susceptibilities and effective treatments against RGM in the world are limited.The aim of this study to compare quantitative parameters of drug susceptibility of M. abscessus subsp. abscessus and M. chelonae.Material and Methods: Investigated 90 cultures M. chelonae and 49 of the M. abscessus subsp. abscessus. Drug...
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Makarova, M., Kudlay, D., Mikhailova, J., Guntupova, L., Saphonova, S., Litvinov, V. Tags: Respiratory infections Source Type: research

Clinical characteristics and outcomes of surgically resected solitary pulmonary nodules due to nontuberculous mycobacterial infections
Granulomas caused by nontuberculous mycobacterial (NTM) pulmonary infections can present as solitary pulmonary nodules (SPNs) mimicking pulmonary malignancies or other infectious granulomas. However, limited data are available regarding the detailed characteristics and outcomes of surgically resected NTM granulomas. We evaluated the characteristics of 49 surgically resected NTM granulomas presenting as SPNs of 49 patients between January 2007 and December 2016. Twenty-five (51%) were male and 27 (55%) were never-smokers. Seven (14%) patients had histories of tuberculosis and 14 (29%) histories of solid tumors. More than ha...
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Choi, Y., Jhun, B. W., Um, S.-W., Kim, H., Kwon, O. J., Kim, H. K., Choi, Y. S., Kim, J., Shim, Y. M., Huh, H. J., Lee, N. Y., Koh, W.-J. Tags: Respiratory infections Source Type: research

Clinical features of radiologically atypical Mycobacterium kansasii lung disease in Japan
Introduction: Mycobacterium kansasii lung disease (MKLD) typically shows unilateral, upper lobe airspace opacification and cavitary disease, but clinical features with atypical disease remain unclear. The goals of the present study were to evaluate characteristics of patients diagnosed MKLD and demonstrate clinical features of patients with unusual radiological features.Methods: We retrospectively identified all patients from whom at least one positive M. kansasii culture was obtained at our hospital using data from electronic medical records from October 2010 to March 2018. We diagnosed patients based on the ATS/IDSA diag...
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Kusaba, Y., Suzuki, M., Morino, E., Takasaki, J., Sugiyama, H. Tags: Respiratory infections Source Type: research

Acute exacerbation of bronchiectasis - reality of a Pneumology Department
Conclusion: For this sample, the patients with more exacerbations were either colonized and/or on domiciliary NIV and/or long term oxygen therapy. Those patients etend to have more severe disease. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Neiva Machado, J. P., Coutinho Costa, J., Costa, F., Costa, T. Tags: Respiratory infections Source Type: research

Occupational tuberculosis in a low prevalence country during 2005-2015
Conclusions: Occupational TB is a rare disease in a low prevalence country afflicting mainly female nurses. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Lindström, I., Koskela, K., Lehtimäki, J., Suojalehto, H. Tags: Occupational and environmental health Source Type: research

Gender differences in the prevalence of dyspnea
Dyspnea is the most important respiratory symptom. Objectivization of its severity is an important evaluation parameter of health condition.Objective: to evaluate the prevalence of respiratory symptoms in the rural population.Results: completed questionnaires 3621 resident, including the 1505 primary health care (PHC) based patients, and 2116 household based patients, living on the territory of the settlements included in the research. The age of the respondents is 53.7 ±1.0 years for PHC based patients and 49.9 ±1.6 years for household based patients. Male is accounted for 31.5% and 34.4% respectively in bot...
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Kotlyarov, S., Bulgakov, A. Tags: Epidemiology Source Type: research

Indoor urban environment and conventional risk factors for paediatric tuberculosis among 1-12 years old children in a megacity in Pakistan: a matched case control study
Conclusions: This study strengthens the evidence that indoor air environment including time spent indoors, SHS (though insignificant), and low socioeconomic condition and being female and belonging to minor communities increase the risk for childhood TB. Concerted efforts are needed to improve indoor air environment in urban areas for healthier future generations. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Sahito, A., Arif, F., Fatmi, Z., Kadir, M. Tags: Epidemiology Source Type: research

Catastrophic total costs due to tuberculosis among affected households in Uganda; prevalence, drivers and policy implications
Conclusions: Free TB care and treatment is not enough to prevent households from incurring catastrophic total costs due to TB. Social protection policies and programs designed to reduce poverty and vulnerability among TB patients are urgently needed. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Batte, C., Kirenga, B., Katamba, A., Baena, I. G. Tags: Epidemiology Source Type: research

Treatment Outcomes of Tuberculosis among New Smear Positive and Retreatment Cases: Retrospective Study in Two Egyptian Governorates
Conclusion: Treatment success rates among new smear positive and retreatment cases were (90.1% and 92.7%) in Gharbia and Menoufia governorates respectively with low poor outcomes which in turn indicated high efficacy and successful application of DOTS. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: El Emeiry, F., Shalaby, S., Ali Abo E-Magd, G. H., Madi, M. Tags: Epidemiology Source Type: research

The Disease Burden of Bronchiectasis in Korea: A National Database Study
The prevalence and disease burden of bronchiectasis in comparison to those of chronic obstructive pulmonary disease (COPD) have not been well elucidated using a national representative database. We compared respiratory symptoms, physical activity, quality of life, and socioeconomic status in subjects with bronchiectasis versus those with COPD or control subjects participating in the Korea National Health and Nutrition Examination Survey 2007-2009. Participants were classified as physician-diagnosed bronchiectasis, COPD and control (those without COPD or bronchiectasis). The prevalence of bronchiectasis in subjects aged 40 ...
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Yang, B., Park, H. Y., Kang, D., Cho, J., Lee, J. S., Lee, S. W., Oh, Y.-M., Kim, S.-H., Sohn, J. W., Yoon, H. J., Lee, H. Tags: Epidemiology Source Type: research

Etiology and clinical characteristics of bronchiectasis in Taiwan: a multi-center cohort study
This study aims to determine etiology and clinical features of bronchiectasis in Taiwan.This multi-center cohort study investigated non-CF bronchiectasis patients newly diagnosed from 2002/1/1 to 2016/12/31. The clinical data was retrieved from five medical centers across Taiwan. The index date was bronchiectasis firstly diagnosed. Known diseases that existed before the index date were regarded as etiologies of bronchiectasis.A total of 15,729 adult patients with bronchiectasis were included. Idiopathic (32%) was the most common cause, followed by post-pneumonia (24%). Other causes included post-tuberculosis (12%), chronic...
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Huang, H. Y., Lo, C.-Y., Chung, F.-T., Yeh, C.-H., Wang, C.-H. Tags: Epidemiology Source Type: research

Bronchial inflammation, respiratory symptoms and lung function in patients who finished treatment for pulmonary tuberculosis: is it the beginning of a new disease?
Conclusion: This study suggests the existence of different celullar patterns once the treatment has finished and supports the basis of a treatment hypothesis. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Palma, I., Castro Zorrilla, L., Resguardo, A., Martinez, D., Troncoso, D., Cruz, V., Vina, J., Alves, L., Natiello, M., Estevan, R., Lazari, N., Medin, M. I., Inwentarz, S., Videla, A., Palmero, D. Tags: Allergy and immunology Source Type: research