Quantitative Proteomic Analysis of the Expression of SARS-CoV-2 Receptors in the Gut of Patients with Chronic Enterocolitis.
In conclusion, gut inflammation associated with chronic colitis does not mediate a further increase in the cellular entry of SARS-CoV-2. PMID: 32975064 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - September 27, 2020 Category: Universities & Medical Training Authors: Park J, Jeong D, Chung YW, Kim DH, Cheon JH, Ryu JH Tags: Yonsei Med J Source Type: research

A rare cutaneous tuberculosis form, erythema induratum of Bazin: 6 years' experience.
CONCLUSIONS: EIB's etiopathogenesis is unknown. In total, 75.0% of the patients receiving tuberculosis treatment and 87.5% of the patients without tuberculosis treatment recovered in our study. The role of tuberculous therapy in the management of EIB is controversial. The selection of appropriate treatment for EIB continues to be an area of debate, and further studies are needed. PMID: 32975298 [PubMed - in process] (Source: Acta Dermatovenerologica Alpina, Panonica, et Adriatica)
Source: Acta Dermatovenerologica Alpina, Panonica, et Adriatica - September 26, 2020 Category: Dermatology Tags: Acta Dermatovenerol Alp Pannonica Adriat Source Type: research

An evolving fungal infection: a case report of disseminated histoplasmosis
An 83-year-old Singaporean man presented to clinic for abdominal pain associated with loss of appetite and weight. He had a significant past medical history of hypertension, hyperlipidaemia, previously treated pulmonary tuberculosis, benign prostatic hyperplasia and peripheral vascular disease. His chronic medications included, aspirin, omeprazole, simvastatin and losartan. Otherwise, he did not have any fever, chills, vomiting, diarrhea, haematochezia, melena, change in bowel habits, cough, dyspnea, chest pain, headache, myalgia, joint pain, dizziness, odynophagia or dysphagia. (Source: The American Journal of Medicine)
Source: The American Journal of Medicine - September 26, 2020 Category: General Medicine Authors: Stephen Ching-Tung So Tags: Diagnostic Dilemma Source Type: research

TB47 and clofazimine form a highly synergistic sterilizing block in a second-line regimen for tuberculosis in mice
Publication date: November 2020Source: Biomedicine & Pharmacotherapy, Volume 131Author(s): Wei Yu, Gift Chiwala, Yamin Gao, Zhiyong Liu, Sanjeep Sapkota, Zhili Lu, Lingmin Guo, Shahzad Akbar Khan, Nanshan Zhong, Tianyu Zhang (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - September 26, 2020 Category: Drugs & Pharmacology Source Type: research

In vitro and in vivo antimicrobial activities of a novel piperazine-containing benzothiazinones candidate TZY-5-84 against Mycobacterium tuberculosis
Publication date: November 2020Source: Biomedicine & Pharmacotherapy, Volume 131Author(s): Shaochen Guo, Lei Fu, Bin Wang, Xi Chen, Jiaojie Zhao, Mingliang Liu, Yu Lu (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - September 26, 2020 Category: Drugs & Pharmacology Source Type: research

[Epidemiological profile of extensively drug-resistant tuberculosis in Peru, 2013-2015Perfil epidemiol ógico da tuberculose extremamente resistente no Peru, 2013-2015].
Conclusions: This study offers important details of the epidemiological profile of XDR-TB in Peru, where there has been an increase in cases of primary XDR-TB; that is, cases with no prior history of disease. Furthermore, this form of tuberculosis has spread to a greater number of departments in the country. PMID: 32973891 [PubMed] (Source: Pan American Journal of Public Health)
Source: Pan American Journal of Public Health - September 26, 2020 Category: International Medicine & Public Health Tags: Rev Panam Salud Publica Source Type: research

Optic Nerve Infiltration in Systemic Metastatic Retinal Lymphoma (SMRL): Multimodal Imaging and Challenges in Diagnosis.
CONCLUSION: Optic nerve infiltration in systemic metastatic retinal lymphoma may have initial occult signs but with profound visual loss. Ocular infections like CMV retinitis and tuberculosis may mask and delay the diagnosis in immunocompromised patients. PMID: 32967510 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)
Source: Ocular Immunology and Inflammation - September 26, 2020 Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research

The seedbeds of Tuberculosis: is it time to target congregate settings and workplaces?
Countries where the incidence of Tuberculosis (TB) is low display a low transmission rate in the general population, and this rate has progressively declined in recent decades; however, TB epidemiology has shown a shift of the disease burden from the general population to specific populations at higher risk, such as vulnerable individuals and hard-to-reach groups. In low-incidence countries, preventive and therapeutic strategies must therefore be geared towards targeted interventions in these populations, with the priority being to promptly identify and treat latent tuberculosis infection (LTBI) rather than manage infectio...
Source: Journal of Preventive Medicine and Hygiene - September 26, 2020 Category: International Medicine & Public Health Authors: Montecucco Montecucco, Guglielmo Dini, Alborz Rahmani, Laura Sticchi, Paolo Durando Source Type: research

Comparative structural and mechanistic studies of 4-hydroxy-tetrahydrodipicolinate reductases from Mycobacterium tuberculosis and Vibrio vulnificus
Publication date: Available online 24 September 2020Source: Biochimica et Biophysica Acta (BBA) - General SubjectsAuthor(s): Swanandi Pote, Sangita Kachhap, Nicholas J. Mank, Leily Daneshian, Vincent Klapper, Sarah Pye, Amy K. Arnette, Linda S. Shimizu, Tomasz Borowski, Maksymilian Chruszcz (Source: Biochimica et Biophysica Acta (BBA) General Subjects)
Source: Biochimica et Biophysica Acta (BBA) General Subjects - September 25, 2020 Category: Biochemistry Source Type: research

Endobronchial Valve Placement for Pulmonary Tuberculosis-related Bronchocutaneous Fistula After Thoracoplasty
No abstract available (Source: Journal of Bronchology and Interventional Pulmonology)
Source: Journal of Bronchology and Interventional Pulmonology - September 25, 2020 Category: Respiratory Medicine Tags: Images in Interventional Pulmonology Source Type: research

Genomic analysis of Latin American-Mediterranean family of Mycobacterium tuberculosis clinical strains from Kazakhstan.
Abstract The human-adapted strains of the Mycobacterium tuberculosis complex (MTBC) comprise seven phylogenetic lineages originally associated with their geographical distribution. Here, we report the genomes of three drug-resistant clinical isolates of the Latin American-Mediterranean (LAM) family collected in Kazakhstan. We utilised whole-genome sequencing to study the distribution and drug resistance of these isolates. Phylogenetic analysis grouped the genomes described in this study with the sequences from Russia, Uzbekistan, and Kazakhstan belonging to the LAM family. One isolate has acquired extensive drug r...
Source: Memorias do Instituto Oswaldo Cruz - September 25, 2020 Category: Infectious Diseases Authors: Tarlykov P, Atavliyeva S, Alenova A, Ramankulov Y Tags: Mem Inst Oswaldo Cruz Source Type: research

Multidrug-resistant tuberculosis in children and adolescents: current strategies for prevention and treatment.
Authors: Seddon JA, Johnson S, Palmer M, van der Zalm MM, Lopez-Varela E, Hughes J, Schaaf HS Abstract Introduction An estimated 30,000 children develop multidrug-resistant (MDR) tuberculosis (TB) each year, with only a small proportion diagnosed and treated. This field has historically been neglected due to a perception that children with MDR-TB are challenging to diagnose and treat. Diagnostic and therapeutic developments in adults have improved paediatric management, yet further paediatric-specific research and wider implementation of evidence-based practices are required. Areas covered This review combines the ...
Source: Expert Review of Respiratory Medicine - September 25, 2020 Category: Respiratory Medicine Tags: Expert Rev Respir Med Source Type: research

Risk of active tuberculosis among COPD patients treated with fixed combinations of long-acting beta2 agonists and inhaled corticosteroids
To investigate the incidence of active tuberculosis (TB) among COPD patients using fluticasone/salmeterol or budesonide/formoterol, and to identify any differences between these two groups of patients. (Source: BMC Infectious Diseases)
Source: BMC Infectious Diseases - September 25, 2020 Category: Infectious Diseases Authors: Tsan-Ming Huang, Kuan-Chih Kuo, Ya-Hui Wang, Cheng-Yi Wang, Chih-Cheng Lai, Hao-Chien Wang, Likwang Chen and Chong-Jen Yu Tags: Research article Source Type: research

Sudden death due to tension pneumothorax associated with pulmonary tuberculosis
AbstractA man in his seventies who lived alone was found dead in his home. Postmortem computed tomography (CT) performed prior to autopsy showed right-sided tension pneumothorax. Autopsy revealed an active pulmonary tuberculosis (TB) lesion. Macroscopic and histopathological findings showed pleural infiltration by TB lesions, suggesting that tension pneumothorax developed in association with TB infection. Routine postmortem CT performed prior to autopsy is useful in screening for TB because the presence of TB lesions can be confirmed from characteristic pulmonary findings. However, it may be difficult to identify tuberculo...
Source: Forensic Science, Medicine, and Pathology - September 24, 2020 Category: Forensic Medicine Source Type: research

Mycobacterium tuberculosis –Specific Antigen Rv3619c Effectively Alleviates Allergic Asthma in Mice
In this study, utilizing a Th1 delivery system to modulate the allergic airway inflammation in a Th2-driven model of asthma, we evaluated the efficacy of immunization with Mycobacterium tuberculosis-specific antigen Rv3619c, either alone or in combination with low dose dexamethasone. The rv3619c gene was cloned in an expression plasmid pGES-TH-1, expressed in Escherichia coli, and the recombinant protein Rv3619c was purified to homogeneity using affinity chromatography. Mice were immunized with the recombinant protein emulsified in Freund’s Incomplete Adjuvant (IFA) alone and in combination with low dose dexamethason...
Source: Frontiers in Pharmacology - September 24, 2020 Category: Drugs & Pharmacology Source Type: research

Complication of Mycobacterium tuberculosis treatment: Isoniazid-induced pneumonitis
A 33-year-old Central American migrant worker developed productive cough, fevers, night sweats, and weight loss over the course of 1 month. A chest X-ray showed a left upper lung zone opacity with cavitation. Computed tomography (CT) of the chest showed extensive, centrilobular tree-in-bud opacities primarily in the left upper lobe with small areas of cavitation (see Fig. 1a). A sputum culture was positive for Mycobacterium tuberculosis, pan-susceptible to minimum inhibitory concentrations of first-line medications for pulmonary tuberculosis. (Source: International Journal of Infectious Diseases)
Source: International Journal of Infectious Diseases - September 24, 2020 Category: Infectious Diseases Authors: Brian Cody Adkinson, Justin De La Fuente, Megan Ninneman, Zain Ahmad Chuadry, Brendan D. Adkinson, Laiqua Khalid Tags: Case Report Source Type: research

Label ‐free molecular detection of antibiotic susceptibility for Mycobacterium smegmatis using a low cost electrode format
This article is protected by copyright. All rights reserved (Source: Biotechnology and Applied Biochemistry)
Source: Biotechnology and Applied Biochemistry - September 24, 2020 Category: Biochemistry Authors: Fatma Dogan Guzel, Hamed Ghorbanpoor, Araz Norouz Dizaji, Iremnur Akcakoca, Yasin Ozturk, Tanil Kocagoz, Damion K Corrigan, Huseyin Avci Tags: Original Article Source Type: research

Calcium ATPase signaling: A must include mechanism in the Radar of therapeutics development against Tuberculosis
This article is protected by copyright. All rights reserved (Source: Biotechnology and Applied Biochemistry)
Source: Biotechnology and Applied Biochemistry - September 24, 2020 Category: Biochemistry Authors: Shivangi, Laxman S. Meena Tags: Review Article Source Type: research

Clinical Characteristics and Etiological Analysis of 133 Patients for Pulmonary Embolism Combined with Hemoptysis
AbstractBackgroundIn the patients with pulmonary embolism (PE), PE itself can cause hemoptysis and other reasons can also cause hemoptysis. Therefore, the clinical  characteristics and the causes of hemoptysis are lacking.MethodsA retrospective  analysis was performed that involved screening 583 PE patients and determining that hemoptysis occurred in 141 cases. Of these, 8 cases were omitted due to anticoagulation‐related hemoptysis or unavailable data, leaving 133 cases that were enrolled in final analysis (127 acute and 6 chronic cas e of PE). We classified the acute PE patients who combined with disease...
Source: The Clinical Respiratory Journal - September 24, 2020 Category: Respiratory Medicine Authors: YongWei Zou, Jun Duan, Xiao ‐Hui Wang, HuanHuan Yang, Jing Chi, Hong Chen Tags: ORIGINAL ARTICLE Source Type: research

Label ‐free molecular detection of antibiotic susceptibility for Mycobacterium smegmatis using a low cost electrode format
This article is protected by copyright. All rights reserved (Source: Biotechnology and Applied Biochemistry)
Source: Biotechnology and Applied Biochemistry - September 24, 2020 Category: Biochemistry Authors: Fatma Dogan Guzel, Hamed Ghorbanpoor, Araz Norouz Dizaji, Iremnur Akcakoca, Yasin Ozturk, Tanil Kocagoz, Damion K Corrigan, Huseyin Avci Tags: Original Article Source Type: research

Calcium ATPase signaling: A must include mechanism in the Radar of therapeutics development against Tuberculosis
This article is protected by copyright. All rights reserved (Source: Biotechnology and Applied Biochemistry)
Source: Biotechnology and Applied Biochemistry - September 24, 2020 Category: Biochemistry Authors: Shivangi, Laxman S. Meena Tags: Review Article Source Type: research

Case Report: Multidrug-Resistant Tuberculosis and COVID-19 Coinfection in Port-au-Prince, Haiti.
We describe a case of a patient with pulmonary MDR-TB and COVID-19 in Port-au-Prince, Haiti, and highlight the challenges and approach to managing a patient with both diseases. PMID: 32978934 [PubMed - as supplied by publisher] (Source: Am J Trop Med Hyg)
Source: Am J Trop Med Hyg - September 24, 2020 Category: Infectious Diseases Authors: Vilbrun SC, Mathurin L, Pape JW, Fitzgerald D, Walsh KF Tags: Am J Trop Med Hyg Source Type: research

Biochemical characterization of ClpB protein from Mycobacterium tuberculosis and identification of its small-molecule inhibitors.
Abstract Tuberculosis, caused by pathogenic M. tuberculosis, remains a global health concern among various infectious diseases. Studies show that ClpB, a major disaggregase, protects the pathogen from various stresses encountered in the host environment. In the present study we have performed a detailed biophysical characterization of M. tuberculosis ClpB followed by a high throughput screening to identify small molecule inhibitors. The sedimentation velocity studies reveal that ClpB oligomerization varies with its concentration and presence of nucleotides. Further, using high throughput malachite green-based scre...
Source: International Journal of Biological Macromolecules - September 24, 2020 Category: Biochemistry Authors: Singh P, Khurana H, Yadav SP, Dhiman K, Singh P, Ashish, Singh R, Sharma D Tags: Int J Biol Macromol Source Type: research

Design and Synthesis of New Indanol-1,2,3-triazole Derivatives as Potent Antitubercular and Antimicrobial Agents.
Abstract In a search of new antitubercular agents, herein we have reported a series of new thirty-two indanol-1,2,3-triazole derivatives. The synthesized compounds were screened for their in vitro antitubercular and antimicrobial activities. Among the screened compounds, most of the compounds have displayed good antitubercular activity against Mycobacterium tuberculosis H37Rv. The compound 5g has been identified as potent antitubercular agent with MIC value 1.56 µM. The most active compounds of the series were further studied for their cytotoxicity against HEK 293 cells using MTT assay and found to be nontox...
Source: Bioorganic and Medicinal Chemistry Letters - September 24, 2020 Category: Chemistry Authors: Phatak PS, Bakale RD, Kulkarni RS, Dhumal ST, Dixit PP, Siva Krishna V, Sriram D, Khedkar VM, Haval KP Tags: Bioorg Med Chem Lett Source Type: research

Chronic Perioral Tuberculosis Skin Lesions in a 21-Year-Old Male
(Source: Infection and Drug Resistance)
Source: Infection and Drug Resistance - September 24, 2020 Category: Infectious Diseases Tags: Infection and Drug Resistance Source Type: research

HIV-induced Retinitis.
CONCLUSION: Targeted antiviral treatment and secondary recurrence prophylaxis prevent vision loss of the retina prior to immune recovery. PMID: 32966142 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)
Source: Ocular Immunology and Inflammation - September 24, 2020 Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research

Recent Trends of Infectious Complications Following Heart Transplantation
Conclusions. A significant reduction in viral, fungal, and Nocardia IEps after heart transplantation was observed, most likely due to advancements in immunosuppression and preventive strategies, including pretransplant infectious diseases screening and antimicrobial prophylaxis. (Source: Transplantation)
Source: Transplantation - September 24, 2020 Category: Transplant Surgery Tags: Original Clinical Science—General Source Type: research

Transbronchial Cryobiopsy for Miliary Tuberculosis Mimicking Hypersensitivity Pneumonitis.
Authors: Nasu S, Kawahara K, Han Y, Okamoto N, Tamura Y, Suzuki H, Shiroyama T, Samejima Y, Kanai T, Noda Y, Tanaka A, Morishita N, Ueda K, Hashimoto S, Hirashima T, Nagai T Abstract Miliary tuberculosis is a potentially lethal type of tuberculosis that results from the hematogenous dissemination of Mycobacterium tuberculosis bacilli. We herein describe the case of a 34-year-old man that presented with a one-month history of cough and fever, while his sputum smear results were negative. Chest computed tomography revealed bilateral centrilobular ground-glass opacification (GGO), suggestive of hypersensitivity pneumo...
Source: Internal Medicine - September 24, 2020 Category: Internal Medicine Tags: Intern Med Source Type: research

GSE158465 Transcriptional response of  Mycobacterium tuberculosis in mouse peritoneal macrophages
This study was conducted to describe transcriptomic changes of M. tuberculosis during macrophage infection. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - September 24, 2020 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mycobacterium tuberculosis H37Rv Source Type: research

Bacterial coinfections in COVID-19: an underestimated adversary.
Authors: Fattorini L, Creti R, Palma C, Pantosti A, Unit of Antibiotic Resistance and Special Pathogens, Unit of Antibiotic Resistance and Special Pathogens of the Department of Infectious Diseases, Istituto Superiore di Sanità, Rome Abstract Current literature shows that secondary bacterial infections, although less frequent than in previous influenza pandemics, affect COVID-19 patients. Mycoplasma pneumoniae, Staphylococcus aureus, Legionella pneumophila, Streptococcus pneumoniae, Haemophilus and Klebsiella spp. are the main species isolated. Of note, Mycobacterium tuberculosis-COVID-19 coinfections are al...
Source: Annali dell Istituto Superiore di Sanita - September 24, 2020 Category: General Medicine Tags: Ann Ist Super Sanita Source Type: research

Leveraging Computational Modeling to Understand Infectious Diseases
We present advances in modeling techniques that have led to fundamental disease discoveries and impacted clinical translation.Recent FindingsCombining mechanistic models and machine learning algorithms has led to improvements in the treatment ofShigella and tuberculosis through the development of novel compounds. Modeling of the epidemic dynamics of malaria at the within-host and between-host level has afforded the development of more effective vaccination and antimalarial therapies. Similarly, in-host and host-host models have supported the development of new HIV treatment modalities and an improved understanding of the i...
Source: Current Pathobiology Reports - September 23, 2020 Category: Laboratory Medicine Source Type: research

Impact of Persistent Anemia on Systemic Inflammation and Tuberculosis Outcomes in Persons Living With HIV
Tuberculosis (TB) is associated with systemic inflammation and anemia, which are aggravated in persons living with HIV (PLWH). Here, we characterized the dynamics of hemoglobin levels in PLWH coinfected with TB undergoing antitubercular therapy (ATT). We also examined the relationships between anemia and systemic inflammatory disturbance as well as the association between persistent anemia and unfavorable clinical outcomes. Data on several blood biochemical parameters and on blood cell counts were retrospectively analyzed in a cohort of 256 TB/HIV patients from Brazil during 180 days of ATT. Multidimensional statistical an...
Source: Frontiers in Immunology - September 23, 2020 Category: Allergy & Immunology Source Type: research

Effect of history of tuberculosis on specificity of Xpert MTB/RIF
Tuberculosis (TB) is the leading cause of mortality among infectious diseases. In 2018, 1.5 million people died due to TB [1]. Early diagnosis of TB is key in achieving WHO End TB targets, and molecular diagnostic tests have been developed. However, molecular tests cannot differentiate between viable and non-viable bacteria [2, 3], leading to challenges in the interpretation of positive test results in patients with recent TB. (Source: European Respiratory Journal)
Source: European Respiratory Journal - September 23, 2020 Category: Respiratory Medicine Authors: Haraka, F., Schumacher, S. G., Ross, A., Mantsoki, A., Gagneux, S., Reither, K., Denkinger, C. M. Tags: Original Articles: Research letters Source Type: research

Insight into the impact of the COVID-19 epidemic on tuberculosis burden in China
We are interested in an article published in the journal recently, entitled "The potential impact of COVID-19-related disruption on tuberculosis burden". The study used a mathematical model to estimate the relative impact of reductions in social contacts and health services on tuberculosis (TB) burden due to the coronavirus disease 2019 (COVID-19) epidemic. There included data and projections on China, being one of 22 high TB burden countries for both TB and multidrug-resistant TB cases. COVID-19, which has spread rapidly and enveloped most of the world, is a unique global public health crisis for the century. By...
Source: European Respiratory Journal - September 23, 2020 Category: Respiratory Medicine Authors: Chen, H., Zhang, K. Tags: Original Articles: Correspondence Source Type: research

IJERPH, Vol. 17, Pages 6993: Identification of Potential Biomarkers and Related Transcription Factors in Peripheral Blood of Tuberculosis Patients
This study aimed to identify the effective diagnosis and therapy biomarkers of TB. Hence, we analyzed two microarray datasets (GSE54992 and GSE62525) derived from the Gene Expression Omnibus (GEO) database to find the differentially expressed genes (DEGs) of peripheral blood mononuclear cell (PBMC) between TB patients and healthy specimens. Functional and pathway enrichment of the DEGs were analyzed by Metascape database. Protein-protein interaction (PPI) network among the DEGs were constructed by STRING databases and visualized in Cytoscape software. The related transcription factors regulatory network of the DEGs was als...
Source: International Journal of Environmental Research and Public Health - September 23, 2020 Category: Environmental Health Authors: Longxiang Xie Xiaoyu Chao Tieshan Teng Qiming Li Jianping Xie Tags: Communication Source Type: research

Can a different cut ‐off value be found in the diagnosis of tuberculous pleurisy in patients aged 40 years and older?
ConclusionADA and the sLDH/pADA ratio are simple, cost ‐efficient, and obtain fast resultsand, therefore, are the preferred methods in TBP diagnosis. The diagnosis rate in the present study was 91% using ADA levels in combination withthesLDH/pADA ratio, both of which can be obtained only through thoracentesis. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - September 23, 2020 Category: Respiratory Medicine Authors: Burcu Arpinar Yigitbas, Celal Satici, A.Filiz Kosar Tags: ORIGINAL ARTICLE Source Type: research

Things must not fall apart: the ripple effects of the COVID-19 pandemic on children in sub-Saharan Africa.
This article focuses on the impact of the COVID-19 pandemic on child health in sub-Saharan Africa. We review the epidemiology of major pediatric diseases and, referencing modeling projections, discuss the short- and long-term impact of the pandemic on major disease control. We deliberate on potential complications of SARS-CoV-2 co-infections/co-morbidities and identify critical social and ethical issues. Furthermore, we highlight the paucity of COVID-19 data and clinical trials in this region and the lack of child participants in ongoing studies. Lastly, approaches and interventions to mitigate the pandemic's impact on chi...
Source: Pediatric Research - September 23, 2020 Category: Pediatrics Authors: Coker M, Folayan MO, Michelow IC, Oladokun RE, Torbunde N, Sam-Agudu NA Tags: Pediatr Res Source Type: research

Symptomatic hepatothorax presenting 25 years after penetrating thoracoabdominal injury.
Abstract Hepatic herniation through the diaphragm is a rare finding. It generally occurs due to a congenital diaphragmatic abnormality or blunt trauma resulting in a diaphragmatic defect. Making the diagnosis is difficult, as there are few definitive clinical signs and chest radiograph (CXR) findings may be non-specific. To our knowledge, only a single case report exists of penetrating right diaphragm injury leading to hepatic herniation. A 42-year-old man presented to the emergency department of a regional hospital with hyperglycaemia and exertional dyspnoea. He was diagnosed with diabetes mellitus type 2. He gav...
Source: Annals of the Royal College of Surgeons of England - September 23, 2020 Category: Surgery Authors: Variawa S, Marais R, Buitendag J, Edge J, Steyn E Tags: Ann R Coll Surg Engl Source Type: research

Design and synthesis of 4-Aminoquinoline-isoindoline-dione-isoniazid triads as potential anti-mycobacterials.
mar V Abstract A series of 4-aminoquinoline-isoindoline-dione-isoniazid triads were synthesized and assessed for their anti-mycobacterial activities and cytotoxicity. Most of the synthesized compounds exhibited promising activities against the mc26230 strain of M. tuberculosis with MIC in the range of 5.1-11.9 µM and were non-cytotoxic against Vero cells. The conjugates lacking either isoniazid or quinoline core in their structural framework failed to inhibit the growth of M. tuberculosis; thus, further strengthening the proposed design of triads in the present study. PMID: 32980514 [PubMed - as supplie...
Source: Bioorganic and Medicinal Chemistry Letters - September 23, 2020 Category: Chemistry Authors: Rani A, Johansen MD, Roquet-Banères F, Kremer L, Awolade P, Ebenezer O, Singh P, Sumanjit, Kumar V Tags: Bioorg Med Chem Lett Source Type: research

Differential Immunogenicity and Protective Efficacy Elicited by MTO- and DMT-Adjuvanted CMFO Subunit Vaccines against Mycobacterium tuberculosis Infection.
In this study, we compared the immunogenicity and protective efficacy of CMFO subunit vaccines against primary progressive TB in two different adjuvant systems: the MTO oil-in-water (O/W) emulsion composed of monophosphoryl lipid A (MPL), trehalose-6,60-dibehenate (TDB), and oil in water emulsion MF59 and the DMT liposome containing dimethyldioctadecylammonium bromide (DDA), monophosphoryl lipid A (MPL), and trehalose-6,60-dibehenate (TDB). Our results demonstrated that the DMT-adjuvanted CMFO could confer more significant protection against M. tuberculosis infection than the CMFO/MTO did in mice. In particular, the adjuva...
Source: Journal of Immunology Research - September 23, 2020 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Disseminated Tuberculosis Confounding a Co-morbid Primary CNS Lymphoma
Publication date: Available online 22 September 2020Source: IDCasesAuthor(s): Don Bambino Geno Tai, Christopher S Graffeo, Amy Kotsenas, Fredric B Meyer, Abinash Virk (Source: IDCases)
Source: IDCases - September 23, 2020 Category: Infectious Diseases Source Type: research

Functional Outcomes in Spinal Tuberculosis: A Review of the Literature.
Authors: Yong LN, Ahmedy F, Yin KN, Engkasan JP Abstract Spinal tuberculosis often leads to neurological deficit and subsequent deterioration in functional outcomes. This review assesses the recent evidence on functional outcomes in spinal tuberculosis, highlighting functional recovery, assessment tools for functional measures, and associative factors for functional recovery. Using PubMed, a literature search was done using the terms "spinal tuberculosis," "tuberculous spondylitis," "tuberculous spondylodiscitis," and "functional outcome" for original articles published betwe...
Source: Asian Spine Journal - September 23, 2020 Category: Orthopaedics Tags: Asian Spine J Source Type: research

HIV and the tuberculosis “set point”: how HIV impairs alveolar macrophage responses to tuberculosis and sets the stage for progressive disease
As HIV has fueled a global resurgence of tuberculosis over the last several decades, there is a growing awareness that HIV-mediated impairments in both innate and adaptive immunity contribute to the heightened... (Source: Retrovirology)
Source: Retrovirology - September 23, 2020 Category: Virology Authors: Sara C. Auld and Bashar S. Staitieh Tags: Review Source Type: research

IL-12 DNA Displays Efficient Adjuvant Effects Improving Immunogenicity of Ag85A in DNA Prime/MVA Boost Immunizations
Mycobacterium tuberculosis (Mtb) infection is one of the leading causes of death worldwide. The Modified Vaccinia Ankara (MVA) vaccine vector expressing the mycobacterial antigen 85A (MVA85A) was demonstrated to be safe, although it did not improve BCG efficacy, denoting the need to search for improved tuberculosis vaccines. In this work, we investigated the effect of IL-12 DNA -as an adjuvant- on an Ag85A DNA prime/MVA85A boost vaccination regimen. We evaluated the immune response profile elicited in mice and the protection conferred against intratracheal Mtb H37Rv challenge. We observed that the immunization scheme inclu...
Source: Frontiers in cellular and infection microbiology - September 22, 2020 Category: Microbiology Source Type: research

Serum sCD14, PGLYRP2 and FGA as potential biomarkers for multidrug-resistant tuberculosis based on data-independent acquisition and targeted proteomics.
Abstract Multidrug-resistant tuberculosis (MDR-TB), defined as tuberculosis (TB) resistant to at least isoniazid and rifampicin, is a major concern of TB control worldwide. However, the diagnosis of MDR-TB remains a huge challenge to its prevention and control. To identify new diagnostic methods for MDR-TB, a mass spectrometry strategy of data-independent acquisition and parallel reaction monitoring was used to detect and validate differential serum proteins. The bioinformatic analysis showed that the functions of differential serum proteins between the MDR-TB group and the drug-sensitive tuberculosis group were s...
Source: J Cell Mol Med - September 22, 2020 Category: Molecular Biology Authors: Chen J, Han YS, Yi WJ, Huang H, Li ZB, Shi LY, Wei LL, Yu Y, Jiang TT, Li JC Tags: J Cell Mol Med Source Type: research

Chest CT scan as an initial diagnostic method for tuberculosis infection detected by mass screening.
Conclusions: Chest CT was not supported as an initial diagnostic method to rule out active TB in patients with a TB infection detected by mass screening in a country with an intermediate TB burden. PMID: 32972119 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - September 22, 2020 Category: Internal Medicine Authors: Joo DH, Lee HW, Yoon SY, Park TY, Heo EY, Kim DK, Chung HS, Lee JK Tags: Korean J Intern Med Source Type: research

Gaining Deeper Insights into the Surface Binding of Bedaquiline Analogues with ATP Synthase Subunit C of Mycobacterium tuberculosis Using Molecular Docking, Molecular Dynamics Simulation and 3D-QSAR Techniques
New J. Chem., 2020, Accepted Manuscript DOI: 10.1039/D0NJ02062A, PaperManisha Lobo, Rajdeep Ray, Gautham G. Shenoy Bedaquiline is a diarylquinoline antimycobacterial drug prescribed for the treatment of Multidrug-Resistant Tuberculosis (MDR-TB). It targets the energy metabolism of the bacteria by inhibiting the proton pump of mycobacterial ATP... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - New J. Chem. latest articles)
Source: RSC - New J. Chem. latest articles - September 22, 2020 Category: Chemistry Authors: Manisha Lobo Source Type: research

Circadian rhythm influences induction of trained immunity by BCG vaccination
CONCLUSIONS BCG vaccination in the morning induces stronger trained immunity and adaptive responses compared with evening vaccination. Future studies should take vaccine administration time into account when studying specific and nonspecific effects of vaccines; early morning should be the preferred moment of BCG administration.FUNDING The Netherlands Organization for Scientific Research, the European Research Council, and the Danish National Research Foundation. (Source: Journal of Clinical Investigation)
Source: Journal of Clinical Investigation - September 22, 2020 Category: Biomedical Science Authors: L. Charlotte J. de Bree, Vera P. Mourits, Valerie A.C.M. Koeken, Simone J.C.F.M. Moorlag, Robine Janssen, Lukas Folkman, Daniele Barreca, Thomas Krausgruber, Victoria Fife-Gernedl, Boris Novakovic, Rob J.W. Arts, Helga Dijkstra, Heidi Lemmers, Christoph B Source Type: research

Antituberculosis BCG vaccination: more reasons for varying innate and adaptive immune responses
Bacillus Calmette-Guérin (BCG) vaccination induces variable protection against pulmonary tuberculosis (TB), and a more effective TB vaccine is needed. The potential for BCG to provide protection against heterologous infections, by induction of innate immune memory, is increasingly recognized. These nonspecific responses may substantially benefit public health, but are also variable. In this issue of the JCI, Koeken and de Bree et al. report that BCG reduces circulating inflammatory markers in males but not in females, while de Bree and Mouritis et al. describe how diurnal rhythms affect the degree of BCG-induced inn...
Source: Journal of Clinical Investigation - September 22, 2020 Category: Biomedical Science Authors: S. Prentice, H.M. Dockrell Source Type: research

Pulmonary tuberculosis presenting secondary organizing pneumonia with organized polypoid granulation tissue: case series and review of the literature
Secondary organizing pneumonia (SOP) is difficult to distinguish from cryptogenic organizing pneumonia (COP) considering various clinical situations. SOP caused by Mycobacterium tuberculosis is rare; indeed, it h... (Source: BMC Pulmonary Medicine)
Source: BMC Pulmonary Medicine - September 22, 2020 Category: Respiratory Medicine Authors: Eun Jin Kim and Kyung Chan Kim Tags: Research article Source Type: research